LRRC4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)6.02001031
2synaptic vesicle maturation (GO:0016188)5.93865809
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.82447314
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.60548030
5vocalization behavior (GO:0071625)5.55606088
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.48389532
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.19462177
8regulation of glutamate receptor signaling pathway (GO:1900449)4.99548985
9synaptic vesicle exocytosis (GO:0016079)4.90724953
10neuron cell-cell adhesion (GO:0007158)4.88783831
11layer formation in cerebral cortex (GO:0021819)4.78259575
12protein localization to synapse (GO:0035418)4.74327989
13glutamate secretion (GO:0014047)4.74237742
14regulation of synaptic vesicle exocytosis (GO:2000300)4.67697639
15exploration behavior (GO:0035640)4.63624252
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.57811349
17regulation of synapse structural plasticity (GO:0051823)4.53402154
18dendritic spine morphogenesis (GO:0060997)4.48557006
19central nervous system myelination (GO:0022010)4.48391988
20axon ensheathment in central nervous system (GO:0032291)4.48391988
21synaptic vesicle docking involved in exocytosis (GO:0016081)4.48106651
22regulation of neuronal synaptic plasticity (GO:0048168)4.36198325
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.35798351
24gamma-aminobutyric acid transport (GO:0015812)4.29281665
25neurotransmitter secretion (GO:0007269)4.27313109
26neurotransmitter-gated ion channel clustering (GO:0072578)4.23243646
27regulation of synaptic vesicle transport (GO:1902803)4.15165020
28synaptic transmission, glutamatergic (GO:0035249)4.07180827
29glutamate receptor signaling pathway (GO:0007215)3.97653198
30neuronal action potential propagation (GO:0019227)3.94083616
31potassium ion homeostasis (GO:0055075)3.88856599
32postsynaptic membrane organization (GO:0001941)3.88611256
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88393997
34auditory behavior (GO:0031223)3.82852505
35amino acid import (GO:0043090)3.80956688
36regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.80938718
37long-term memory (GO:0007616)3.73892644
38positive regulation of membrane potential (GO:0045838)3.73161811
39neuron recognition (GO:0008038)3.72522945
40neuron-neuron synaptic transmission (GO:0007270)3.71081358
41cellular potassium ion homeostasis (GO:0030007)3.70009981
42establishment of mitochondrion localization (GO:0051654)3.67134135
43dendrite morphogenesis (GO:0048813)3.65541688
44sodium ion export (GO:0071436)3.63563774
45proline transport (GO:0015824)3.63308649
46potassium ion import (GO:0010107)3.62621041
47regulation of dendritic spine morphogenesis (GO:0061001)3.62023269
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61333981
49cell communication by electrical coupling (GO:0010644)3.57032346
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.53435055
51positive regulation of synapse maturation (GO:0090129)3.53278862
52neuromuscular process controlling balance (GO:0050885)3.52751136
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50342876
54glycine transport (GO:0015816)3.49839104
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.48894245
56axonal fasciculation (GO:0007413)3.48267139
57response to auditory stimulus (GO:0010996)3.47958317
58pyrimidine nucleobase catabolic process (GO:0006208)3.45783536
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.45478032
60activation of protein kinase A activity (GO:0034199)3.45133055
61neurotransmitter transport (GO:0006836)3.43483510
62regulation of postsynaptic membrane potential (GO:0060078)3.43337020
63regulation of synapse maturation (GO:0090128)3.39138854
64transmission of nerve impulse (GO:0019226)3.38317949
65regulation of synaptic plasticity (GO:0048167)3.36566335
66positive regulation of dendritic spine morphogenesis (GO:0061003)3.33439136
67cellular sodium ion homeostasis (GO:0006883)3.30643721
68presynaptic membrane assembly (GO:0097105)3.29004466
69prepulse inhibition (GO:0060134)3.24623683
70regulation of synaptic transmission, glutamatergic (GO:0051966)3.23429281
71regulation of voltage-gated calcium channel activity (GO:1901385)3.22741067
72cell migration in hindbrain (GO:0021535)3.21889517
73cerebellar granule cell differentiation (GO:0021707)3.21858978
74regulation of neurotransmitter levels (GO:0001505)3.20211757
75regulation of neurotransmitter secretion (GO:0046928)3.19257823
76neuronal ion channel clustering (GO:0045161)3.19056433
77positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.17210905
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16918487
79L-amino acid import (GO:0043092)3.16473250
80presynaptic membrane organization (GO:0097090)3.15684723
81positive regulation of dendritic spine development (GO:0060999)3.13990387
82cerebellar Purkinje cell differentiation (GO:0021702)3.12821092
83dendritic spine organization (GO:0097061)3.12149616
84synaptic vesicle endocytosis (GO:0048488)3.12035200
85establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.10901150
86mitochondrion transport along microtubule (GO:0047497)3.10901150
87regulation of dendritic spine development (GO:0060998)3.08157441
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06242458
89negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05738625
90membrane hyperpolarization (GO:0060081)3.05589598
91long-term synaptic potentiation (GO:0060291)3.04278289
92synapse assembly (GO:0007416)3.03314883
93mechanosensory behavior (GO:0007638)3.00847582
94learning (GO:0007612)3.00377941
95G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.00326546
96regulation of neurotransmitter transport (GO:0051588)2.98950656
97innervation (GO:0060384)2.98606727
98G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98397657
99neuromuscular synaptic transmission (GO:0007274)2.97932553
100acidic amino acid transport (GO:0015800)2.97571311
101cerebellar Purkinje cell layer development (GO:0021680)2.96286372
102membrane depolarization (GO:0051899)2.96120037
103central nervous system projection neuron axonogenesis (GO:0021952)2.95901670
104regulation of respiratory system process (GO:0044065)2.94646948
105regulation of vesicle fusion (GO:0031338)2.93980371
106adult walking behavior (GO:0007628)2.93705457
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.93566138
108positive regulation of dendrite development (GO:1900006)2.93442187
109neuromuscular process controlling posture (GO:0050884)2.92275956
110cell differentiation in hindbrain (GO:0021533)2.90021061
111neuromuscular process (GO:0050905)2.90005427
112membrane depolarization during action potential (GO:0086010)2.88905356
113synapse organization (GO:0050808)2.88043985
114regulation of ARF protein signal transduction (GO:0032012)2.86661305
115negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86162381
116gamma-aminobutyric acid signaling pathway (GO:0007214)2.85756615
117positive regulation of neurotransmitter transport (GO:0051590)2.85225917
118positive regulation of neurotransmitter secretion (GO:0001956)2.85154830

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95393997
2JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16623297
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12120936
4GBX2_23144817_ChIP-Seq_PC3_Human3.09993242
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.09525102
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.83536375
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.83536375
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74918986
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.70736528
10* REST_21632747_ChIP-Seq_MESCs_Mouse2.67295116
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.64602534
12DROSHA_22980978_ChIP-Seq_HELA_Human2.62408836
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57326695
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56445264
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56239684
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.54343527
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53640749
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.43658429
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40362588
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.32156967
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.31589657
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30407604
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.22276537
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17944534
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.16467240
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16016473
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13513308
28AR_21572438_ChIP-Seq_LNCaP_Human2.00145297
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.96949779
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92395503
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78204953
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.67511096
33TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.58612630
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54844016
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.49865683
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44677332
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39561825
38SMAD4_21799915_ChIP-Seq_A2780_Human1.37912675
39RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.35528125
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35442050
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35427913
42ZNF274_21170338_ChIP-Seq_K562_Hela1.33524761
43RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.32703777
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32256432
45* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29651047
46KDM2B_26808549_Chip-Seq_K562_Human1.28038352
47RING1B_27294783_Chip-Seq_NPCs_Mouse1.27602497
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.27040840
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.26769646
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25908550
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25711207
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25458020
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.24176019
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24032042
55* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22944062
56AR_19668381_ChIP-Seq_PC3_Human1.19400346
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16732960
58* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16108225
59LXR_22292898_ChIP-Seq_THP-1_Human1.15812076
60EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14679949
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13921432
62TAF15_26573619_Chip-Seq_HEK293_Human1.11387174
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10610181
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08582128
65STAT3_23295773_ChIP-Seq_U87_Human1.06970673
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06908640
67AR_25329375_ChIP-Seq_VCAP_Human1.04060138
68P300_19829295_ChIP-Seq_ESCs_Human1.04058549
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03917173
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03742406
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03169167
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02050409
73ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01965590
74YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00856466
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00353393
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.99910093
77ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99685784
78ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99331595
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98583112
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98164417
81SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97823593
82RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97653520
83AHR_22903824_ChIP-Seq_MCF-7_Human0.97641835
84SMAD_19615063_ChIP-ChIP_OVARY_Human0.97460070
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.95724901
86* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95581086
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94281745
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94141553
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.94094421
90TCF4_23295773_ChIP-Seq_U87_Human0.93408083
91* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92642789
92RNF2_27304074_Chip-Seq_NSC_Mouse0.92559558
93SMC4_20622854_ChIP-Seq_HELA_Human0.91572683
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91484796
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91349426
96NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91316828
97KDM2B_26808549_Chip-Seq_DND41_Human0.91253050
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.90972346
99CTCF_27219007_Chip-Seq_Bcells_Human0.90445566
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.89988777
101GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89189755
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89184180
103* OCT4_19829295_ChIP-Seq_ESCs_Human0.88264644
104EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87885273
105KDM2B_26808549_Chip-Seq_JURKAT_Human0.87264143
106* TET1_21490601_ChIP-Seq_MESCs_Mouse0.86260403
107TP53_20018659_ChIP-ChIP_R1E_Mouse0.85445842
108PRDM14_20953172_ChIP-Seq_ESCs_Human0.84157364
109DPY_21335234_ChIP-Seq_ESCs_Mouse0.84135372
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83353901
111KLF4_19829295_ChIP-Seq_ESCs_Human0.83244972
112BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83111877
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82263018
114RUNX2_22187159_ChIP-Seq_PCA_Human0.82190136
115CREB1_26743006_Chip-Seq_LNCaP_Human0.81530358
116POU5F1_16518401_ChIP-PET_MESCs_Mouse0.81509220
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.81307045
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.80913634
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80833841
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.80356015
121SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80066909
122PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78558165
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.78550111
124NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76984391
125* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.76788604
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.76280440
127TP53_23651856_ChIP-Seq_MEFs_Mouse0.74922686
128P68_20966046_ChIP-Seq_HELA_Human0.74576511
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74501505
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74256075

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.53934192
2MP0003880_abnormal_central_pattern4.59994127
3MP0003635_abnormal_synaptic_transmissio4.10421456
4MP0004270_analgesia3.63212293
5MP0009745_abnormal_behavioral_response3.34235974
6MP0002063_abnormal_learning/memory/cond3.29960306
7MP0005423_abnormal_somatic_nervous3.20761949
8MP0002064_seizures3.10024047
9MP0009046_muscle_twitch2.91907423
10MP0002572_abnormal_emotion/affect_behav2.68709427
11MP0002822_catalepsy2.67174418
12MP0001486_abnormal_startle_reflex2.63327768
13MP0001968_abnormal_touch/_nociception2.59456081
14MP0002734_abnormal_mechanical_nocicepti2.51277606
15MP0002272_abnormal_nervous_system2.48700474
16MP0000778_abnormal_nervous_system2.20359376
17MP0004858_abnormal_nervous_system2.08373228
18MP0009780_abnormal_chondrocyte_physiolo2.07737343
19MP0008569_lethality_at_weaning2.00834042
20MP0001440_abnormal_grooming_behavior1.97988851
21MP0002733_abnormal_thermal_nociception1.92591654
22MP0004885_abnormal_endolymph1.92580691
23MP0003329_amyloid_beta_deposits1.89853293
24MP0001501_abnormal_sleep_pattern1.88932215
25MP0002736_abnormal_nociception_after1.87273987
26MP0001970_abnormal_pain_threshold1.85749554
27MP0002067_abnormal_sensory_capabilities1.84397887
28MP0004811_abnormal_neuron_physiology1.82548182
29MP0002184_abnormal_innervation1.80583332
30MP0002557_abnormal_social/conspecific_i1.80476850
31MP0002735_abnormal_chemical_nociception1.79094231
32MP0005386_behavior/neurological_phenoty1.72592126
33MP0004924_abnormal_behavior1.72592126
34MP0000955_abnormal_spinal_cord1.70305160
35MP0005646_abnormal_pituitary_gland1.63697534
36MP0002909_abnormal_adrenal_gland1.63662524
37MP0002882_abnormal_neuron_morphology1.50674554
38MP0003123_paternal_imprinting1.47025897
39MP0004142_abnormal_muscle_tone1.46083878
40MP0002066_abnormal_motor_capabilities/c1.45578997
41MP0001984_abnormal_olfaction1.40367955
42MP0000751_myopathy1.39688578
43MP0003633_abnormal_nervous_system1.35625127
44MP0003787_abnormal_imprinting1.34701603
45MP0006276_abnormal_autonomic_nervous1.33316073
46MP0003879_abnormal_hair_cell1.32749034
47MP0000566_synostosis1.31245536
48MP0001529_abnormal_vocalization1.31055249
49MP0005645_abnormal_hypothalamus_physiol1.29112231
50MP0001502_abnormal_circadian_rhythm1.26896957
51MP0002152_abnormal_brain_morphology1.25269912
52MP0001905_abnormal_dopamine_level1.21986919
53MP0000920_abnormal_myelination1.21049140
54MP0003690_abnormal_glial_cell1.18771063
55MP0003631_nervous_system_phenotype1.16218094
56MP0003634_abnormal_glial_cell1.14463807
57MP0002249_abnormal_larynx_morphology1.12026708
58MP0003122_maternal_imprinting1.11366145
59MP0003137_abnormal_impulse_conducting1.06825995
60MP0006292_abnormal_olfactory_placode1.05740437
61MP0002638_abnormal_pupillary_reflex1.04958104
62MP0003121_genomic_imprinting1.02188102
63MP0004085_abnormal_heartbeat1.02123254
64MP0001177_atelectasis1.00115678
65MP0003136_yellow_coat_color0.99908452
66MP0005377_hearing/vestibular/ear_phenot0.99189654
67MP0003878_abnormal_ear_physiology0.99189654
68MP0002229_neurodegeneration0.99003903
69MP0004215_abnormal_myocardial_fiber0.98092235
70MP0004742_abnormal_vestibular_system0.97655955
71MP0003938_abnormal_ear_development0.96730277
72MP0004145_abnormal_muscle_electrophysio0.95879315
73MP0000026_abnormal_inner_ear0.93624104
74MP0002069_abnormal_eating/drinking_beha0.91913255
75MP0003283_abnormal_digestive_organ0.91222048
76MP0000631_abnormal_neuroendocrine_gland0.90162689
77MP0003632_abnormal_nervous_system0.89023570
78MP0005623_abnormal_meninges_morphology0.85824606
79MP0002837_dystrophic_cardiac_calcinosis0.84900321
80MP0003075_altered_response_to0.83758988
81MP0009379_abnormal_foot_pigmentation0.82546624
82MP0005551_abnormal_eye_electrophysiolog0.82241820
83MP0000569_abnormal_digit_pigmentation0.81916243
84MP0000579_abnormal_nail_morphology0.81695706
85MP0001346_abnormal_lacrimal_gland0.80857997
86MP0002752_abnormal_somatic_nervous0.80355083
87MP0008961_abnormal_basal_metabolism0.80179731
88MP0001485_abnormal_pinna_reflex0.79942694
89MP0008874_decreased_physiological_sensi0.78739457
90MP0005394_taste/olfaction_phenotype0.78579579
91MP0005499_abnormal_olfactory_system0.78579579
92MP0001963_abnormal_hearing_physiology0.78369639
93MP0008872_abnormal_physiological_respon0.76631205
94MP0000604_amyloidosis0.75580015
95MP0003861_abnormal_nervous_system0.75152226
96MP0004233_abnormal_muscle_weight0.73793731
97MP0001188_hyperpigmentation0.73489401
98MP0005167_abnormal_blood-brain_barrier0.73316455
99MP0005409_darkened_coat_color0.72489984
100MP0000013_abnormal_adipose_tissue0.71228822
101MP0003646_muscle_fatigue0.70666325
102MP0001299_abnormal_eye_distance/0.69458883
103MP0004130_abnormal_muscle_cell0.68442294
104MP0002090_abnormal_vision0.68076122
105MP0005535_abnormal_body_temperature0.66609017
106MP0001348_abnormal_lacrimal_gland0.66039346
107MP0004484_altered_response_of0.63716029
108MP0001943_abnormal_respiration0.62197373
109MP0002081_perinatal_lethality0.61241490
110MP0002653_abnormal_ependyma_morphology0.60961417
111MP0010769_abnormal_survival0.60335149
112MP0000534_abnormal_ureter_morphology0.59307561
113MP0002082_postnatal_lethality0.57442673
114MP0010770_preweaning_lethality0.57442673
115MP0004133_heterotaxia0.57430054
116MP0004043_abnormal_pH_regulation0.56827975
117MP0010768_mortality/aging0.56109995
118MP0000747_muscle_weakness0.55191838

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.81794697
2Focal motor seizures (HP:0011153)6.29863826
3Focal seizures (HP:0007359)4.97113608
4Visual hallucinations (HP:0002367)4.73170009
5Epileptic encephalopathy (HP:0200134)4.16715120
6Action tremor (HP:0002345)4.01111774
7Progressive cerebellar ataxia (HP:0002073)3.98653013
8Supranuclear gaze palsy (HP:0000605)3.96708528
9Ankle clonus (HP:0011448)3.79764202
10Broad-based gait (HP:0002136)3.46518883
11Atonic seizures (HP:0010819)3.46132023
12Mutism (HP:0002300)3.37543026
13Febrile seizures (HP:0002373)3.37417296
14Absence seizures (HP:0002121)3.27379289
15Poor eye contact (HP:0000817)3.23934501
16Generalized tonic-clonic seizures (HP:0002069)3.23560544
17Depression (HP:0000716)3.21410591
18Impaired vibration sensation in the lower limbs (HP:0002166)3.16835631
19Urinary bladder sphincter dysfunction (HP:0002839)3.15231340
20Dysdiadochokinesis (HP:0002075)3.09632540
21Megalencephaly (HP:0001355)3.05522197
22Dialeptic seizures (HP:0011146)2.99216707
23Dysmetria (HP:0001310)2.97873521
24Anxiety (HP:0000739)2.96571142
25Neurofibrillary tangles (HP:0002185)2.96304840
26Postural instability (HP:0002172)2.95438896
27Impaired social interactions (HP:0000735)2.92635492
28Abnormal social behavior (HP:0012433)2.92635492
29Genetic anticipation (HP:0003743)2.88765433
30Gaze-evoked nystagmus (HP:0000640)2.88451955
31Abnormal eating behavior (HP:0100738)2.85837521
32Urinary urgency (HP:0000012)2.80253238
33Drooling (HP:0002307)2.77679630
34Excessive salivation (HP:0003781)2.77679630
35Torticollis (HP:0000473)2.77634705
36Hemiparesis (HP:0001269)2.76278736
37Spastic gait (HP:0002064)2.75214707
38Hyperventilation (HP:0002883)2.73852992
39Abnormality of the corticospinal tract (HP:0002492)2.72304207
40Truncal ataxia (HP:0002078)2.71606367
41Turricephaly (HP:0000262)2.71439491
42Cerebral inclusion bodies (HP:0100314)2.69835033
43Cerebral hypomyelination (HP:0006808)2.69540572
44Ventricular fibrillation (HP:0001663)2.68679775
45Intention tremor (HP:0002080)2.68322117
46Papilledema (HP:0001085)2.65385378
47Limb dystonia (HP:0002451)2.62809600
48Focal dystonia (HP:0004373)2.57785212
49Abnormality of the lower motor neuron (HP:0002366)2.53763107
50Progressive inability to walk (HP:0002505)2.53204722
51Hemiplegia (HP:0002301)2.53163312
52Status epilepticus (HP:0002133)2.51856078
53Termporal pattern (HP:0011008)2.49677111
54Insidious onset (HP:0003587)2.49677111
55Pheochromocytoma (HP:0002666)2.43016103
56Amblyopia (HP:0000646)2.42848997
57Insomnia (HP:0100785)2.42413599
58Lower limb muscle weakness (HP:0007340)2.40299318
59Diplopia (HP:0000651)2.40271750
60Abnormality of binocular vision (HP:0011514)2.40271750
61Obstructive sleep apnea (HP:0002870)2.37542097
62Stereotypic behavior (HP:0000733)2.34278016
63Scanning speech (HP:0002168)2.34103392
64Bundle branch block (HP:0011710)2.31731447
65Tetraplegia (HP:0002445)2.30553662
66Bradykinesia (HP:0002067)2.25616287
67Craniofacial dystonia (HP:0012179)2.24531359
68Epileptiform EEG discharges (HP:0011182)2.24030769
69Amyotrophic lateral sclerosis (HP:0007354)2.20999941
70EEG with generalized epileptiform discharges (HP:0011198)2.20760102
71Impaired smooth pursuit (HP:0007772)2.19938739
72Shallow orbits (HP:0000586)2.18629792
73Spinal canal stenosis (HP:0003416)2.18309627
74Split foot (HP:0001839)2.18095347
75Hypsarrhythmia (HP:0002521)2.17142066
76Spastic tetraparesis (HP:0001285)2.16910931
77Polyphagia (HP:0002591)2.14512009
78Pointed chin (HP:0000307)2.13989184
79Abnormal EKG (HP:0003115)2.12978395
80Aplasia involving bones of the upper limbs (HP:0009823)2.12466300
81Aplasia of the phalanges of the hand (HP:0009802)2.12466300
82Aplasia involving bones of the extremities (HP:0009825)2.12466300
83Delusions (HP:0000746)2.12328190
84Fetal akinesia sequence (HP:0001989)2.11020635
85Prolonged QT interval (HP:0001657)2.10918800
86Dysmetric saccades (HP:0000641)2.08554868
87Hyperacusis (HP:0010780)2.05672671
88Abnormality of the diencephalon (HP:0010662)2.04863449
89Agitation (HP:0000713)2.04641143
90Impaired vibratory sensation (HP:0002495)2.04161420
91Hyperthyroidism (HP:0000836)2.02844908
92Bronchomalacia (HP:0002780)2.00944671
93Lower limb asymmetry (HP:0100559)1.99819147
94Neuroendocrine neoplasm (HP:0100634)1.99622090
95Absent speech (HP:0001344)1.98245711
96Overriding aorta (HP:0002623)1.97929095
97Lower limb amyotrophy (HP:0007210)1.96585465
98Annular pancreas (HP:0001734)1.96171160
99Abnormality of ocular smooth pursuit (HP:0000617)1.95518679
100Diminished motivation (HP:0000745)1.93775959
101Morphological abnormality of the pyramidal tract (HP:0002062)1.92837946
102Clonus (HP:0002169)1.92661555
103Akinesia (HP:0002304)1.91883656
104Incomplete penetrance (HP:0003829)1.89534803
105Coronal craniosynostosis (HP:0004440)1.89310799
106Generalized myoclonic seizures (HP:0002123)1.89073699
107Neoplasm of the peripheral nervous system (HP:0100007)1.89005288
108Elfin facies (HP:0004428)1.88215547
109Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86343757
110Degeneration of the lateral corticospinal tracts (HP:0002314)1.86343757
111Sudden death (HP:0001699)1.86063255
112Truncus arteriosus (HP:0001660)1.85459359
113Apathy (HP:0000741)1.84446044
114Neuronal loss in central nervous system (HP:0002529)1.81585188
115Septo-optic dysplasia (HP:0100842)1.80503040
116Sleep apnea (HP:0010535)1.80009664
117Abnormality of salivation (HP:0100755)1.79990834
118Peripheral hypomyelination (HP:0007182)1.78994326
119Inability to walk (HP:0002540)1.78527057
120Blue irides (HP:0000635)1.77908138
121Hypoplasia of the corpus callosum (HP:0002079)1.77827637
122Inappropriate behavior (HP:0000719)1.77649768
123Rigidity (HP:0002063)1.75131874
124Morphological abnormality of the inner ear (HP:0011390)1.73631378
125Rapidly progressive (HP:0003678)1.73269929
126Thickened helices (HP:0000391)1.69128799
127Cutaneous finger syndactyly (HP:0010554)1.68955630

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.38579786
2EPHA43.88077290
3NTRK33.85317780
4MAP3K93.56091031
5MAP3K42.60384525
6NTRK22.56561857
7MINK12.55296915
8PAK62.50942188
9PRKD32.30954563
10DAPK22.27642828
11MAP2K72.09585811
12CAMKK11.88054825
13NTRK11.83943473
14PRPF4B1.78537432
15KSR21.78439241
16PHKG21.77385787
17PHKG11.77385787
18CASK1.71971480
19CDK51.62543326
20KSR11.62276640
21TNIK1.61151601
22MAPK131.52032771
23TYRO31.47502085
24MAP2K41.43568458
25UHMK11.41586520
26SIK21.33651756
27PLK21.22909523
28STK381.18480736
29PRKCG1.15675186
30CDK191.12660565
31LMTK21.12608045
32LATS21.11705448
33DAPK11.11073138
34TAOK11.08298753
35MAP3K121.06636799
36FES1.04578331
37GRK51.04323463
38SGK2231.04085945
39SGK4941.04085945
40CDK151.00072372
41STK110.99712032
42CDK180.99482819
43PNCK0.98282581
44PAK30.97722657
45CAMK2A0.95473047
46PRKCH0.94484522
47CDK140.93702145
48RIPK40.89187719
49ALK0.89069781
50CAMK10.88789323
51CDK11A0.87426205
52PKN10.86385424
53EPHB20.85893129
54ARAF0.83244492
55CSNK1G20.82812802
56MARK20.82152649
57ICK0.82009110
58MAP3K20.81408535
59PINK10.80012091
60CAMK2B0.78469642
61RET0.77756883
62CAMKK20.76898806
63MAP3K110.75102746
64OXSR10.74021787
65DYRK1A0.72455421
66SGK30.70442929
67SGK20.70276232
68SGK10.66369065
69DMPK0.63996422
70PRKCZ0.62566541
71CDC42BPA0.59585594
72PDPK10.56814412
73PDK10.55822344
74ROCK20.55772850
75MAP3K130.55542406
76NEK60.55510650
77ERBB20.55308465
78RIPK10.53483266
79CAMK1G0.53057892
80RPS6KA30.52539561
81LIMK10.52324903
82BRAF0.52142244
83FYN0.51876231
84CAMK2D0.50841496
85PRKCE0.50701546
86RAF10.50593341
87ROCK10.48464504
88CAMK40.47840748
89CAMK2G0.47584161
90DYRK20.47387450
91DAPK30.47269044
92MUSK0.45648028
93MAP3K70.43913273
94FGFR20.43555344
95PTK2B0.43467730
96NEK10.42099402
97MAPK100.41603573
98STK390.41321376
99WNK10.39544823
100RPS6KA20.39497613
101MOS0.39150480
102CAMK1D0.38947144
103CSNK1G30.38583222
104BRSK10.36681201
105FGR0.36138941
106MAPK120.36028814
107MAPK80.33069672
108EEF2K0.32819751
109GSK3B0.32272128
110PDGFRA0.31395991
111TNK20.30512707
112PRKCA0.29358694
113CSNK1E0.28513842
114MAPK40.27852794
115PRKDC0.27803854

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.35042289
2Synaptic vesicle cycle_Homo sapiens_hsa047213.00700129
3Olfactory transduction_Homo sapiens_hsa047402.71448982
4GABAergic synapse_Homo sapiens_hsa047272.69584228
5Circadian entrainment_Homo sapiens_hsa047132.64259151
6Glutamatergic synapse_Homo sapiens_hsa047242.57250020
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.44646650
8Long-term potentiation_Homo sapiens_hsa047202.40895528
9Morphine addiction_Homo sapiens_hsa050322.40505950
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22818165
11Amphetamine addiction_Homo sapiens_hsa050312.22715331
12Salivary secretion_Homo sapiens_hsa049702.08560052
13Dopaminergic synapse_Homo sapiens_hsa047282.07588153
14Cholinergic synapse_Homo sapiens_hsa047251.93285387
15Gastric acid secretion_Homo sapiens_hsa049711.91711365
16Insulin secretion_Homo sapiens_hsa049111.89245178
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83699901
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.75684183
19Cocaine addiction_Homo sapiens_hsa050301.71706375
20Oxytocin signaling pathway_Homo sapiens_hsa049211.60790401
21Long-term depression_Homo sapiens_hsa047301.60628811
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.60175356
23Renin secretion_Homo sapiens_hsa049241.59344120
24Taste transduction_Homo sapiens_hsa047421.54838190
25Serotonergic synapse_Homo sapiens_hsa047261.51004692
26Calcium signaling pathway_Homo sapiens_hsa040201.49775667
27Gap junction_Homo sapiens_hsa045401.46971093
28Axon guidance_Homo sapiens_hsa043601.46477772
29Nitrogen metabolism_Homo sapiens_hsa009101.46206793
30GnRH signaling pathway_Homo sapiens_hsa049121.38935664
31Vitamin B6 metabolism_Homo sapiens_hsa007501.32799016
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31305329
33cAMP signaling pathway_Homo sapiens_hsa040241.28327869
34Cardiac muscle contraction_Homo sapiens_hsa042601.23292356
35Type II diabetes mellitus_Homo sapiens_hsa049301.21320356
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21002286
37Glioma_Homo sapiens_hsa052141.20660445
38Estrogen signaling pathway_Homo sapiens_hsa049151.17271459
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12740851
40ErbB signaling pathway_Homo sapiens_hsa040121.11896108
41Melanogenesis_Homo sapiens_hsa049161.11403202
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08889879
43Dilated cardiomyopathy_Homo sapiens_hsa054141.06012123
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04921667
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00551116
46Phospholipase D signaling pathway_Homo sapiens_hsa040720.95718717
47Collecting duct acid secretion_Homo sapiens_hsa049660.95430435
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.90284267
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88778350
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88123353
51Dorso-ventral axis formation_Homo sapiens_hsa043200.85639929
52Hippo signaling pathway_Homo sapiens_hsa043900.82401958
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81229371
54Oocyte meiosis_Homo sapiens_hsa041140.79583293
55Pancreatic secretion_Homo sapiens_hsa049720.76398655
56Choline metabolism in cancer_Homo sapiens_hsa052310.72327211
57Basal cell carcinoma_Homo sapiens_hsa052170.72028702
58MAPK signaling pathway_Homo sapiens_hsa040100.71834386
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.70270607
60Thyroid hormone synthesis_Homo sapiens_hsa049180.68992021
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68324635
62Endometrial cancer_Homo sapiens_hsa052130.68313818
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67855582
64Phototransduction_Homo sapiens_hsa047440.66822917
65Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65819611
66Vibrio cholerae infection_Homo sapiens_hsa051100.64956759
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63879049
68Ras signaling pathway_Homo sapiens_hsa040140.63796157
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63789584
70Renal cell carcinoma_Homo sapiens_hsa052110.61487825
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61057398
72Rap1 signaling pathway_Homo sapiens_hsa040150.60448382
73VEGF signaling pathway_Homo sapiens_hsa043700.60298844
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.60084627
75* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59791710
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58227400
77Endocytosis_Homo sapiens_hsa041440.56898620
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56589728
79Alcoholism_Homo sapiens_hsa050340.56130024
80Bile secretion_Homo sapiens_hsa049760.54843726
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54782928
82mTOR signaling pathway_Homo sapiens_hsa041500.53020990
83Notch signaling pathway_Homo sapiens_hsa043300.52589442
84Wnt signaling pathway_Homo sapiens_hsa043100.51669992
85Non-small cell lung cancer_Homo sapiens_hsa052230.51315067
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49399678
87Glucagon signaling pathway_Homo sapiens_hsa049220.49380485
88Insulin signaling pathway_Homo sapiens_hsa049100.47639359
89Prion diseases_Homo sapiens_hsa050200.47463463
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47066760
91Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44793785
92Ovarian steroidogenesis_Homo sapiens_hsa049130.41722439
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39219217
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39119954
95Colorectal cancer_Homo sapiens_hsa052100.37569681
96Tight junction_Homo sapiens_hsa045300.37313327
97Inositol phosphate metabolism_Homo sapiens_hsa005620.35976178
98Type I diabetes mellitus_Homo sapiens_hsa049400.35533247
99Chemokine signaling pathway_Homo sapiens_hsa040620.34887804
100Butanoate metabolism_Homo sapiens_hsa006500.34852024
101AMPK signaling pathway_Homo sapiens_hsa041520.33088473
102Hedgehog signaling pathway_Homo sapiens_hsa043400.32687930
103Arginine and proline metabolism_Homo sapiens_hsa003300.32331985
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32272665
105Fatty acid biosynthesis_Homo sapiens_hsa000610.31944196
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31276065
107Circadian rhythm_Homo sapiens_hsa047100.30438444
108Protein digestion and absorption_Homo sapiens_hsa049740.29565571
109Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28230518
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28041368

Most similar genes based on co-expression Upload to Enrichr

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