LRRC45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.92339927
2proline metabolic process (GO:0006560)6.50211742
3transcription from mitochondrial promoter (GO:0006390)6.44074746
4establishment of apical/basal cell polarity (GO:0035089)6.05074269
5embryonic process involved in female pregnancy (GO:0060136)5.82736848
6positive regulation of protein homooligomerization (GO:0032464)5.73091251
7regulation of protein homooligomerization (GO:0032462)5.37582904
8establishment or maintenance of monopolar cell polarity (GO:0061339)5.17834678
9establishment of monopolar cell polarity (GO:0061162)5.17834678
10regulation of integrin activation (GO:0033623)5.17329391
11oxidative demethylation (GO:0070989)5.11350472
12replication fork processing (GO:0031297)5.08716800
13regulation of mammary gland epithelial cell proliferation (GO:0033599)5.05046545
14poly(A)+ mRNA export from nucleus (GO:0016973)4.93369139
15cellular response to ATP (GO:0071318)4.88112205
16protein retention in ER lumen (GO:0006621)4.87713852
17mitotic G1 DNA damage checkpoint (GO:0031571)4.79692103
18negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.66301171
19negative regulation of protein oligomerization (GO:0032460)4.57903549
20synaptic vesicle endocytosis (GO:0048488)4.50709364
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.41355076
22mitochondrial DNA metabolic process (GO:0032042)4.34662728
23DNA unwinding involved in DNA replication (GO:0006268)4.33294019
24negative regulation of Ras GTPase activity (GO:0034261)4.16904789
25mitotic chromosome condensation (GO:0007076)4.13362726
26mitotic G1/S transition checkpoint (GO:0044819)4.09203073
27signal complex assembly (GO:0007172)4.03936537
28COPI coating of Golgi vesicle (GO:0048205)4.01073102
29Golgi transport vesicle coating (GO:0048200)4.01073102
30N-glycan processing (GO:0006491)3.98584278
31regulation of protein oligomerization (GO:0032459)3.97459982
32G1 DNA damage checkpoint (GO:0044783)3.97204682
33negative regulation of JAK-STAT cascade (GO:0046426)3.95414836
34protein localization to endosome (GO:0036010)3.95211844
35negative regulation of mRNA processing (GO:0050686)3.93513819
36negative regulation of cell size (GO:0045792)3.92157787
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.87409173
38DNA deamination (GO:0045006)3.86338842
39DNA strand renaturation (GO:0000733)3.86103939
40positive regulation of developmental pigmentation (GO:0048087)3.84651056
41planar cell polarity pathway involved in neural tube closure (GO:0090179)3.83195065
42positive regulation of protein oligomerization (GO:0032461)3.82624796
43peptidyl-arginine omega-N-methylation (GO:0035247)3.80785366
44regulation of translational fidelity (GO:0006450)3.76708047
45embryonic placenta development (GO:0001892)3.70432130
46positive regulation by host of viral transcription (GO:0043923)3.69756398
47cell migration in hindbrain (GO:0021535)3.66294221
48regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.61637785
49spliceosomal tri-snRNP complex assembly (GO:0000244)3.58243001
50positive regulation of dendritic spine morphogenesis (GO:0061003)3.56546711
51regulation of chromatin binding (GO:0035561)3.56541469
52DNA strand elongation involved in DNA replication (GO:0006271)3.56436729
53regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.56071150
54negative regulation of cell cycle arrest (GO:0071157)3.53885875
55maternal placenta development (GO:0001893)3.52261166
56convergent extension (GO:0060026)3.51939275
57DNA strand elongation (GO:0022616)3.51717975
58negative regulation of RNA splicing (GO:0033119)3.48788559
59viral mRNA export from host cell nucleus (GO:0046784)3.44496832
60DNA replication initiation (GO:0006270)3.43926084
61mRNA cleavage (GO:0006379)3.42353259
62glial cell migration (GO:0008347)3.41497696
63activation of Rac GTPase activity (GO:0032863)3.35478474
64intracellular estrogen receptor signaling pathway (GO:0030520)3.35168575
65glutamine family amino acid biosynthetic process (GO:0009084)3.34860666
66regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34454853
67negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.32847379
68somatic hypermutation of immunoglobulin genes (GO:0016446)3.31762480
69somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31762480
70regulation of mitochondrial depolarization (GO:0051900)3.31677223
71regulation of cAMP-dependent protein kinase activity (GO:2000479)3.30735070
72folic acid metabolic process (GO:0046655)3.26640780
73negative regulation of heart rate (GO:0010459)3.24537147
74urea cycle (GO:0000050)3.22988382
75negative regulation of response to food (GO:0032096)3.22947183
76negative regulation of appetite (GO:0032099)3.22947183
77negative regulation of mRNA metabolic process (GO:1903312)3.22694422
78neuromuscular process controlling posture (GO:0050884)3.21137872
79mRNA stabilization (GO:0048255)3.19619468
80RNA stabilization (GO:0043489)3.19619468
81pentose-phosphate shunt (GO:0006098)3.19133441
82glucose catabolic process (GO:0006007)3.18427316
83retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18019332
84protein complex localization (GO:0031503)3.17445904
85adherens junction assembly (GO:0034333)3.15586669
86regulation of response to reactive oxygen species (GO:1901031)3.14980012
87ribosomal small subunit biogenesis (GO:0042274)3.11958144
88heterochromatin organization (GO:0070828)3.11825720
89DNA integration (GO:0015074)3.10487791
90retinoic acid receptor signaling pathway (GO:0048384)3.09913850
91snRNA metabolic process (GO:0016073)3.09701688
92positive regulation of Cdc42 GTPase activity (GO:0043089)3.09018736
93regulation of ARF GTPase activity (GO:0032312)3.08951717
94phospholipid scrambling (GO:0017121)3.08951441
95cellular response to zinc ion (GO:0071294)3.08496469
96rRNA transcription (GO:0009303)3.08238013
97membrane tubulation (GO:0097320)3.07559420
98anatomical structure regression (GO:0060033)3.06835787
99histone H4-K12 acetylation (GO:0043983)3.06227853
100histone arginine methylation (GO:0034969)3.05519966
101telomere maintenance via semi-conservative replication (GO:0032201)3.05118375
102motile cilium assembly (GO:0044458)3.03247850
103regulation of cholesterol biosynthetic process (GO:0045540)3.02748338
104semaphorin-plexin signaling pathway (GO:0071526)2.99919048
105base-excision repair (GO:0006284)2.97654275
106DNA duplex unwinding (GO:0032508)2.97525431
107apoptotic process involved in morphogenesis (GO:0060561)2.97385248
108establishment or maintenance of bipolar cell polarity (GO:0061245)2.96761463
109establishment or maintenance of apical/basal cell polarity (GO:0035088)2.96761463
110peptidyl-arginine methylation (GO:0018216)2.96719938
111peptidyl-arginine N-methylation (GO:0035246)2.96719938
112cellular protein complex localization (GO:0034629)2.96194944
113hypotonic response (GO:0006971)2.93410192
1143-UTR-mediated mRNA stabilization (GO:0070935)2.92495606
115face development (GO:0060324)2.92461819
116protein-DNA complex disassembly (GO:0032986)2.92137757
117nucleosome disassembly (GO:0006337)2.92137757
118urea metabolic process (GO:0019627)2.90736967
119embryonic camera-type eye development (GO:0031076)2.90112478
120head development (GO:0060322)2.89640542
121regulation of glucose import in response to insulin stimulus (GO:2001273)2.89561605
122oxygen transport (GO:0015671)2.88612733
123dosage compensation (GO:0007549)2.87992219
124UV protection (GO:0009650)2.86768365
125regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.86078261
126termination of RNA polymerase II transcription (GO:0006369)2.85839776
127nodal signaling pathway (GO:0038092)2.84665946
128regulation of early endosome to late endosome transport (GO:2000641)2.83232570
129pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83009671
130focal adhesion assembly (GO:0048041)2.80120538
131cell-substrate adherens junction assembly (GO:0007045)2.80120538
132protein maturation by protein folding (GO:0022417)2.79876956
133regulation of respiratory system process (GO:0044065)2.79505841
134negative regulation of DNA-templated transcription, elongation (GO:0032785)2.78941067
135positive regulation of receptor recycling (GO:0001921)2.78166902
136protein targeting to vacuole (GO:0006623)2.77976670
137protein targeting to lysosome (GO:0006622)2.77976670
138establishment of protein localization to vacuole (GO:0072666)2.77976670
139regulation of NFAT protein import into nucleus (GO:0051532)2.77840799
140positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.77723516
141protein insertion into membrane (GO:0051205)2.75887926
142neuromuscular process controlling balance (GO:0050885)2.75028848
143formation of translation preinitiation complex (GO:0001731)2.74425951
144mannose metabolic process (GO:0006013)2.74060401
145negative regulation of GTP catabolic process (GO:0033125)2.72665106
146negative regulation of GTPase activity (GO:0034260)2.72665106
147DNA geometric change (GO:0032392)2.72549759
148chromosome condensation (GO:0030261)2.72060718
149modulation by virus of host process (GO:0019054)2.71499910
150NADPH regeneration (GO:0006740)2.70466588
151GDP-mannose metabolic process (GO:0019673)2.70409105
152proximal/distal pattern formation (GO:0009954)2.69809684
153axonemal dynein complex assembly (GO:0070286)2.69711326
154negative regulation of erythrocyte differentiation (GO:0045647)2.68879026
155negative regulation of adherens junction organization (GO:1903392)2.67988664
156negative regulation of focal adhesion assembly (GO:0051895)2.67988664
157negative regulation of cell junction assembly (GO:1901889)2.67988664
158basement membrane organization (GO:0071711)2.67098989
159locomotory exploration behavior (GO:0035641)2.66289041
160pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.65601022
161pentose metabolic process (GO:0019321)2.64425182
162positive regulation of DNA-dependent DNA replication (GO:2000105)2.64225320
163base-excision repair, AP site formation (GO:0006285)2.64187422
164DNA replication checkpoint (GO:0000076)2.61853682
165mitotic sister chromatid segregation (GO:0000070)2.56880745
166regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.54942577
167cellular response to epidermal growth factor stimulus (GO:0071364)2.54934284
168snRNA processing (GO:0016180)2.54594979
169nucleobase-containing small molecule interconversion (GO:0015949)2.51959383
170ncRNA 3-end processing (GO:0043628)2.51707895
171L-serine metabolic process (GO:0006563)2.49925336
172diaphragm development (GO:0060539)2.49046769
173dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.49017253
174positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.47781325
175DNA conformation change (GO:0071103)2.47339492
176lung epithelium development (GO:0060428)2.47145456
177embryonic skeletal joint morphogenesis (GO:0060272)2.46999056
178nuclear pore complex assembly (GO:0051292)2.44787688
179pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.44512146
180negative regulation of viral release from host cell (GO:1902187)2.43862400
181regulation of fatty acid beta-oxidation (GO:0031998)2.43470178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.11275851
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.47934774
3LXR_22292898_ChIP-Seq_THP-1_Human3.13130692
4VDR_21846776_ChIP-Seq_THP-1_Human3.10326529
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.05675366
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.04234746
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.94710335
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.85927660
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.49607984
10KDM2B_26808549_Chip-Seq_SUP-B15_Human2.44321299
11MYC_22102868_ChIP-Seq_BL_Human2.37415555
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.30928752
13KDM2B_26808549_Chip-Seq_DND41_Human2.30547057
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.29311754
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.25461292
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.23886374
17ZFP281_27345836_Chip-Seq_ESCs_Mouse2.12354159
18KDM2B_26808549_Chip-Seq_K562_Human2.04343218
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.03010144
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.03010144
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.03010144
22KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02104523
23RACK7_27058665_Chip-Seq_MCF-7_Human1.98985630
24ZNF263_19887448_ChIP-Seq_K562_Human1.95229877
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92263281
26CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.91406548
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87033832
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.86282358
29SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.85959582
30POU5F1_16518401_ChIP-PET_MESCs_Mouse1.85233368
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.84790898
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.81553911
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.80809738
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80682527
35MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77480050
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.72036826
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71004641
38TCF7_22412390_ChIP-Seq_EML_Mouse1.69116683
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68780502
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.68631236
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.66792554
42XRN2_22483619_ChIP-Seq_HELA_Human1.66180972
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63420112
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63129782
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55521091
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54193461
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.54081882
48DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53771228
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52692942
50PU.1_20513432_ChIP-Seq_Bcells_Mouse1.50644569
51P68_20966046_ChIP-Seq_HELA_Human1.48699820
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.47509777
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47113954
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47063337
55DROSHA_22980978_ChIP-Seq_HELA_Human1.46958166
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46294402
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45468126
58CTCF_27219007_Chip-Seq_Bcells_Human1.45106443
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44700803
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44460834
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43984059
62CTCF_21964334_ChIP-Seq_BJAB-B_Human1.43228036
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42528812
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.42365877
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41500557
66SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40644802
67* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40557075
68SA1_27219007_Chip-Seq_ERYTHROID_Human1.39917854
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.37727274
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37576335
71SMC4_20622854_ChIP-Seq_HELA_Human1.36845105
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.36785488
73TET1_21490601_ChIP-Seq_MESCs_Mouse1.36655955
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36304649
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.35827711
76VDR_24763502_ChIP-Seq_THP-1_Human1.35578318
77P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35363840
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35292743
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35236403
80BCOR_27268052_Chip-Seq_Bcells_Human1.33079503
81CREB1_26743006_Chip-Seq_LNCaP_Human1.32906687
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.32302742
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.29938677
84ETS1_21867929_ChIP-Seq_TH2_Mouse1.28714833
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.28709448
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28268508
87NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.27936723
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27547955
89RING1B_27294783_Chip-Seq_NPCs_Mouse1.26586468
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25683711
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.24393955
92E2F1_20622854_ChIP-Seq_HELA_Human1.23506180
93MAF_26560356_Chip-Seq_TH2_Human1.22730342
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22581456
95* TP53_23651856_ChIP-Seq_MEFs_Mouse1.22546519
96MAF_26560356_Chip-Seq_TH1_Human1.21944902
97OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.21292562
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21025430
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20646463
100CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20646251
101SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20532584
102PHF8_20622854_ChIP-Seq_HELA_Human1.19516061
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18448106
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17544288
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17066998
106KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16782909
107ATF3_27146783_Chip-Seq_COLON_Human1.16480911
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16466210
109NCOR1_26117541_ChIP-Seq_K562_Human1.16373580
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15983130
111JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15013091
112NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14444613
113* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13584097
114NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13447515
115POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12828908
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.12131815
117RUNX1_27514584_Chip-Seq_MCF-7_Human1.12122112
118GABP_19822575_ChIP-Seq_HepG2_Human1.10889530
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.10843994
120KDM5A_27292631_Chip-Seq_BREAST_Human1.10564069
121* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10477518
122BCL6_27268052_Chip-Seq_Bcells_Human1.10175956
123YY1_22570637_ChIP-Seq_MALME-3M_Human1.10003083
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09079035
125TP63_17297297_ChIP-ChIP_HaCaT_Human1.07642905
126NANOG_21062744_ChIP-ChIP_HESCs_Human1.07410747
127RARA_24833708_ChIP-Seq_LIVER_Mouse1.06679541
128ESR2_21235772_ChIP-Seq_MCF-7_Human1.06474749
129E2F1_21310950_ChIP-Seq_MCF-7_Human1.06212804
130CDX2_20551321_ChIP-Seq_CACO-2_Human1.05850438
131GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05526393
132PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05457686
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05453762
134TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.04975780
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04595657
136SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04534072
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02777018
138* TP63_22573176_ChIP-Seq_HFKS_Human1.01800658
139EGR1_19374776_ChIP-ChIP_THP-1_Human1.01577597
140MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01571546
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01479455
142* FOXP1_21924763_ChIP-Seq_HESCs_Human1.01365046
143NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.01001893
144OCT4_19829295_ChIP-Seq_ESCs_Human1.00987260
145SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00924456
146* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00301508
147REST_21632747_ChIP-Seq_MESCs_Mouse1.00028204
148UTX_26944678_Chip-Seq_JUKART_Human0.99297374
149REST_18959480_ChIP-ChIP_MESCs_Mouse0.99187823
150TP53_22127205_ChIP-Seq_IMR90_Human0.99005319

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009278_abnormal_bone_marrow4.97496155
2MP0003705_abnormal_hypodermis_morpholog4.11333745
3MP0003283_abnormal_digestive_organ3.99931085
4MP0008057_abnormal_DNA_replication3.58508312
5MP0004859_abnormal_synaptic_plasticity3.51754123
6MP0010030_abnormal_orbit_morphology3.22477123
7MP0004233_abnormal_muscle_weight3.17933027
8MP0004185_abnormal_adipocyte_glucose3.09652787
9MP0005174_abnormal_tail_pigmentation3.03784136
10MP0003111_abnormal_nucleus_morphology2.82593910
11MP0005171_absent_coat_pigmentation2.77560996
12MP0005451_abnormal_body_composition2.62365672
13MP0002877_abnormal_melanocyte_morpholog2.54332366
14MP0000537_abnormal_urethra_morphology2.49173151
15MP0004133_heterotaxia2.38423655
16MP0003693_abnormal_embryo_hatching2.32800085
17MP0003172_abnormal_lysosome_physiology2.32003710
18MP0006072_abnormal_retinal_apoptosis2.29208952
19MP0002009_preneoplasia2.27090375
20MP0000566_synostosis2.26147918
21MP0002249_abnormal_larynx_morphology2.25918687
22MP0005397_hematopoietic_system_phenotyp2.15249276
23MP0001545_abnormal_hematopoietic_system2.15249276
24MP0010094_abnormal_chromosome_stability2.12168030
25MP0008995_early_reproductive_senescence2.01673339
26MP0003077_abnormal_cell_cycle1.93039813
27MP0005076_abnormal_cell_differentiation1.92465574
28MP0004957_abnormal_blastocyst_morpholog1.91522188
29MP0003119_abnormal_digestive_system1.83324186
30MP0008260_abnormal_autophagy1.82867721
31MP0005501_abnormal_skin_physiology1.82471854
32MP0001730_embryonic_growth_arrest1.79235441
33MP0000462_abnormal_digestive_system1.72503187
34MP0000015_abnormal_ear_pigmentation1.68514436
35MP0005623_abnormal_meninges_morphology1.67734064
36MP0002653_abnormal_ependyma_morphology1.67147615
37MP0005666_abnormal_adipose_tissue1.65477132
38MP0001346_abnormal_lacrimal_gland1.61717037
39MP0000470_abnormal_stomach_morphology1.60938882
40MP0003045_fibrosis1.56946372
41MP0005075_abnormal_melanosome_morpholog1.53534868
42MP0000371_diluted_coat_color1.53277357
43MP0010234_abnormal_vibrissa_follicle1.53034009
44MP0003635_abnormal_synaptic_transmissio1.52389849
45MP0003123_paternal_imprinting1.50990589
46MP0000003_abnormal_adipose_tissue1.50417186
47MP0005409_darkened_coat_color1.48971133
48MP0000858_altered_metastatic_potential1.45269304
49MP0003566_abnormal_cell_adhesion1.44792369
50MP0000350_abnormal_cell_proliferation1.44279390
51MP0005645_abnormal_hypothalamus_physiol1.43738828
52MP0000955_abnormal_spinal_cord1.42723115
53MP0009672_abnormal_birth_weight1.40770808
54MP0008932_abnormal_embryonic_tissue1.40393099
55MP0003453_abnormal_keratinocyte_physiol1.38287214
56MP0000678_abnormal_parathyroid_gland1.36228416
57MP0002089_abnormal_postnatal_growth/wei1.35955534
58MP0005083_abnormal_biliary_tract1.35662290
59MP0001293_anophthalmia1.34345046
60MP0002080_prenatal_lethality1.32316726
61MP0002282_abnormal_trachea_morphology1.31513958
62MP0005360_urolithiasis1.31044495
63MP0001348_abnormal_lacrimal_gland1.29666293
64MP0005058_abnormal_lysosome_morphology1.29534740
65MP0002733_abnormal_thermal_nociception1.28842510
66MP0005375_adipose_tissue_phenotype1.28342932
67MP0002063_abnormal_learning/memory/cond1.26770198
68MP0009046_muscle_twitch1.24075852
69MP0000733_abnormal_muscle_development1.24042748
70MP0003890_abnormal_embryonic-extraembry1.23975671
71MP0002098_abnormal_vibrissa_morphology1.23804984
72MP0001672_abnormal_embryogenesis/_devel1.22662901
73MP0005380_embryogenesis_phenotype1.22662901
74MP0000467_abnormal_esophagus_morphology1.21917387
75MP0009333_abnormal_splenocyte_physiolog1.21827418
76MP0005220_abnormal_exocrine_pancreas1.20166810
77MP0002084_abnormal_developmental_patter1.19989780
78MP0002064_seizures1.19017804
79MP0004811_abnormal_neuron_physiology1.15837674
80MP0001970_abnormal_pain_threshold1.15285053
81MP0002572_abnormal_emotion/affect_behav1.13276076
82MP0000685_abnormal_immune_system1.13258312
83MP0001849_ear_inflammation1.13068352
84MP0000579_abnormal_nail_morphology1.11477440
85MP0003984_embryonic_growth_retardation1.10183267
86MP0010307_abnormal_tumor_latency1.09457763
87MP0009053_abnormal_anal_canal1.09038390
88MP0000049_abnormal_middle_ear1.08417555
89MP0004885_abnormal_endolymph1.06661616
90MP0000313_abnormal_cell_death1.06193201
91MP0005670_abnormal_white_adipose1.05919349
92MP0004782_abnormal_surfactant_physiolog1.05404804
93MP0004264_abnormal_extraembryonic_tissu1.04825500
94MP0002396_abnormal_hematopoietic_system1.04508275
95MP0002932_abnormal_joint_morphology1.04322985
96MP0002822_catalepsy1.03266783
97MP0005621_abnormal_cell_physiology1.02756704
98MP0000778_abnormal_nervous_system1.01040164
99MP0002088_abnormal_embryonic_growth/wei1.00823136
100MP0001661_extended_life_span1.00311245
101MP0002269_muscular_atrophy0.99390985
102MP0003935_abnormal_craniofacial_develop0.97264804
103MP0004947_skin_inflammation0.95766092
104MP0002085_abnormal_embryonic_tissue0.94878039
105MP0000477_abnormal_intestine_morphology0.93988558
106MP0003075_altered_response_to0.93467920
107MP0001340_abnormal_eyelid_morphology0.92316897
108MP0002060_abnormal_skin_morphology0.92234530
109MP0002086_abnormal_extraembryonic_tissu0.91229080
110MP0009840_abnormal_foam_cell0.90732106
111MP0002796_impaired_skin_barrier0.90006653
112MP0002075_abnormal_coat/hair_pigmentati0.89524131
113MP0003115_abnormal_respiratory_system0.89411046
114MP0000490_abnormal_crypts_of0.89408969
115MP0000569_abnormal_digit_pigmentation0.89341667
116MP0003137_abnormal_impulse_conducting0.88645015
117MP0003942_abnormal_urinary_system0.88500074
118MP0003763_abnormal_thymus_physiology0.88321113
119MP0002092_abnormal_eye_morphology0.87800236
120MP0003633_abnormal_nervous_system0.87096218
121MP0008961_abnormal_basal_metabolism0.86639174
122MP0003191_abnormal_cellular_cholesterol0.86234749
123MP0005257_abnormal_intraocular_pressure0.86121761
124MP0004381_abnormal_hair_follicle0.85994183
125MP0008007_abnormal_cellular_replicative0.85113791
126MP0005384_cellular_phenotype0.84980219
127MP0005377_hearing/vestibular/ear_phenot0.84874489
128MP0003878_abnormal_ear_physiology0.84874489
129MP0002970_abnormal_white_adipose0.84047207
130MP0001873_stomach_inflammation0.83824494
131MP0001216_abnormal_epidermal_layer0.83465572
132MP0002114_abnormal_axial_skeleton0.82467990
133MP0009931_abnormal_skin_appearance0.81706085
134MP0005253_abnormal_eye_physiology0.81624324
135MP0002116_abnormal_craniofacial_bone0.81110305
136MP0002882_abnormal_neuron_morphology0.81088817
137MP0000681_abnormal_thyroid_gland0.80293444
138MP0002019_abnormal_tumor_incidence0.79081570
139MP0008569_lethality_at_weaning0.78920224
140MP0001324_abnormal_eye_pigmentation0.78079776
141MP0002111_abnormal_tail_morphology0.77717078
142MP0003755_abnormal_palate_morphology0.77545658
143MP0000703_abnormal_thymus_morphology0.77103369
144MP0001697_abnormal_embryo_size0.75896552
145MP0000358_abnormal_cell_content/0.75402146
146MP0003315_abnormal_perineum_morphology0.75207346
147MP0003861_abnormal_nervous_system0.74363689
148MP0000639_abnormal_adrenal_gland0.72854540
149MP0010352_gastrointestinal_tract_polyps0.72465221
150MP0010768_mortality/aging0.71777536
151MP0004808_abnormal_hematopoietic_stem0.71729432
152MP0002234_abnormal_pharynx_morphology0.69948381
153MP0009745_abnormal_behavioral_response0.69714102
154MP0002152_abnormal_brain_morphology0.69586277
155MP0001502_abnormal_circadian_rhythm0.69452960
156MP0000747_muscle_weakness0.69094241
157MP0002697_abnormal_eye_size0.69003890
158MP0000762_abnormal_tongue_morphology0.68973779
159MP0010769_abnormal_survival0.68897810
160MP0002184_abnormal_innervation0.67831750
161MP0003786_premature_aging0.67784956
162MP0000377_abnormal_hair_follicle0.67512986
163MP0010630_abnormal_cardiac_muscle0.67442085
164MP0005391_vision/eye_phenotype0.66740624
165MP0004858_abnormal_nervous_system0.65606064
166MP0004197_abnormal_fetal_growth/weight/0.65295280
167MP0002909_abnormal_adrenal_gland0.64508640
168MP0002066_abnormal_motor_capabilities/c0.63991550
169MP0000751_myopathy0.63609795
170MP0002272_abnormal_nervous_system0.62917417

Predicted human phenotypes

RankGene SetZ-score
1Annular pancreas (HP:0001734)5.43723876
2Turricephaly (HP:0000262)5.29560386
3Ulnar bowing (HP:0003031)4.04515249
4Rib fusion (HP:0000902)4.00953201
5Concave nail (HP:0001598)3.96295886
6Poikiloderma (HP:0001029)3.91426098
7Pustule (HP:0200039)3.83188769
8Anteriorly placed anus (HP:0001545)3.63554338
9Alopecia of scalp (HP:0002293)3.46223343
10Cerebral aneurysm (HP:0004944)3.36595593
11Abnormality of the distal phalanges of the toes (HP:0010182)3.26832485
12Flat acetabular roof (HP:0003180)3.26110217
13Facial hemangioma (HP:0000329)3.25062439
14Congenital hip dislocation (HP:0001374)3.22465975
15Hypochromic microcytic anemia (HP:0004840)3.18599991
16Abnormality of the aortic arch (HP:0012303)3.18440677
17Coronal craniosynostosis (HP:0004440)3.13232681
18Intestinal fistula (HP:0100819)3.12342559
19Broad face (HP:0000283)3.05115827
20Hemorrhage of the eye (HP:0011885)3.01692789
21Stridor (HP:0010307)2.99737660
22Rectovaginal fistula (HP:0000143)2.98129576
23Rectal fistula (HP:0100590)2.98129576
24Nasal polyposis (HP:0100582)2.96271929
25Intestinal atresia (HP:0011100)2.93321962
26Myokymia (HP:0002411)2.91182953
27Short chin (HP:0000331)2.89976974
28Increased IgM level (HP:0003496)2.88639308
29Achilles tendon contracture (HP:0001771)2.87240309
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.85898071
31Mucopolysacchariduria (HP:0008155)2.83698483
32Urinary glycosaminoglycan excretion (HP:0003541)2.83698483
33Dysostosis multiplex (HP:0000943)2.83180185
34Alacrima (HP:0000522)2.81777701
35Deep venous thrombosis (HP:0002625)2.75444941
36Bowed forearm bones (HP:0003956)2.73528587
37Bowing of the arm (HP:0006488)2.73528587
38Premature skin wrinkling (HP:0100678)2.71805452
39Albinism (HP:0001022)2.71604385
40Vaginal fistula (HP:0004320)2.71566998
41Abnormality of the Achilles tendon (HP:0005109)2.68279201
42Hypochromic anemia (HP:0001931)2.67323659
43Orthostatic hypotension (HP:0001278)2.66648322
44Hypotelorism (HP:0000601)2.64731242
45Abnormality of mucopolysaccharide metabolism (HP:0011020)2.63915134
46Abnormality of polysaccharide metabolism (HP:0011012)2.63915134
47Abnormality of glycosaminoglycan metabolism (HP:0004371)2.63915134
48Short humerus (HP:0005792)2.62833709
49Vertebral hypoplasia (HP:0008417)2.62137249
50Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.62137249
51Male infertility (HP:0003251)2.60024263
52Asymmetry of the thorax (HP:0001555)2.59768532
53Hyperacusis (HP:0010780)2.55368329
54Thin bony cortex (HP:0002753)2.55151991
55Lip pit (HP:0100267)2.54697313
56Acute lymphatic leukemia (HP:0006721)2.53020009
57Long palpebral fissure (HP:0000637)2.52746024
58Abnormality of the thoracic spine (HP:0100711)2.50548773
59Joint stiffness (HP:0001387)2.49471344
60Hamartoma (HP:0010566)2.48444716
61Abnormality of the nasal mucosa (HP:0000433)2.47859507
62Hypercortisolism (HP:0001578)2.46771948
63Growth hormone excess (HP:0000845)2.46761058
64Large for gestational age (HP:0001520)2.43926302
65Self-mutilation (HP:0000742)2.43236529
66Hyperparathyroidism (HP:0000843)2.43175207
67Distal upper limb amyotrophy (HP:0007149)2.43127494
68Upper limb amyotrophy (HP:0009129)2.43127494
69Narrow nasal bridge (HP:0000446)2.40360385
70Sparse lateral eyebrow (HP:0005338)2.38464764
71Abnormal hemoglobin (HP:0011902)2.37857215
72Decreased lacrimation (HP:0000633)2.36347268
73Selective tooth agenesis (HP:0001592)2.35758815
74Congenital glaucoma (HP:0001087)2.35383901
75Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.34374414
76J-shaped sella turcica (HP:0002680)2.33993054
77Aplasia/hypoplasia of the humerus (HP:0006507)2.33241236
78Atelectasis (HP:0100750)2.32324651
79Aplasia/Hypoplasia of the sacrum (HP:0008517)2.30865339
80Basal cell carcinoma (HP:0002671)2.30335605
81Volvulus (HP:0002580)2.29786612
82Trismus (HP:0000211)2.26330031
83Tongue fasciculations (HP:0001308)2.24050254
84Abnormality of the fingertips (HP:0001211)2.23588923
85Tented upper lip vermilion (HP:0010804)2.23011068
86Biconcave vertebral bodies (HP:0004586)2.22956823
87Disproportionate tall stature (HP:0001519)2.17739672
88Hypokinesia (HP:0002375)2.16258840
89Dysautonomia (HP:0002459)2.14837498
90Insomnia (HP:0100785)2.14454467
91Polycythemia (HP:0001901)2.13605735
92Split hand (HP:0001171)2.12640366
93Hypotrichosis (HP:0001006)2.11906472
94Abnormality of the distal phalanx of the thumb (HP:0009617)2.10788431
95Astrocytoma (HP:0009592)2.10496030
96Abnormality of the astrocytes (HP:0100707)2.10496030
97Amelogenesis imperfecta (HP:0000705)2.10470678
98Chronic bronchitis (HP:0004469)2.10233341
99Septate vagina (HP:0001153)2.09995119
100Abnormality of the umbilical cord (HP:0010881)2.09778259
101Broad thumb (HP:0011304)2.09628070
102Progressive muscle weakness (HP:0003323)2.09438450
103Gastrointestinal atresia (HP:0002589)2.08162136
104Thoracic kyphosis (HP:0002942)2.07009900
105Vertebral compression fractures (HP:0002953)2.05840946
106Broad alveolar ridges (HP:0000187)2.05811261
107Distal lower limb amyotrophy (HP:0008944)2.05704213
108Abnormality of male internal genitalia (HP:0000022)2.01447235
109Short nail (HP:0001799)2.00711705
110Ragged-red muscle fibers (HP:0003200)1.98466619
111Popliteal pterygium (HP:0009756)1.98409721
112Testicular atrophy (HP:0000029)1.97330060
113Pointed chin (HP:0000307)1.96774333
114Clumsiness (HP:0002312)1.96405141
115Muscle fibrillation (HP:0010546)1.94298559
116Abnormality of monocarboxylic acid metabolism (HP:0010996)1.94224832
117Neoplasm of the heart (HP:0100544)1.93963640
118Abnormality of the lower motor neuron (HP:0002366)1.93854568
119Bifid uvula (HP:0000193)1.93742029
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93217800
121Recurrent otitis media (HP:0000403)1.92655626
122Visual hallucinations (HP:0002367)1.90932577
123Spinal cord compression (HP:0002176)1.89490185
124Choanal stenosis (HP:0000452)1.88921280
125Cheilitis (HP:0100825)1.88770156
126Abnormality of the phalanges of the hallux (HP:0010057)1.87339979
127Germ cell neoplasia (HP:0100728)1.86687015
128Obstructive sleep apnea (HP:0002870)1.86310589
129Flattened epiphyses (HP:0003071)1.86283202
130Hand muscle atrophy (HP:0009130)1.86034413
131Colitis (HP:0002583)1.85684612
132Cholecystitis (HP:0001082)1.85497999
133Abnormal gallbladder physiology (HP:0012438)1.85497999
134Cervical subluxation (HP:0003308)1.85116140
135Rectal prolapse (HP:0002035)1.84032171
136Patellar dislocation (HP:0002999)1.81972943
137Dysmetric saccades (HP:0000641)1.81337309
138Rhinitis (HP:0012384)1.81259502
139Overriding aorta (HP:0002623)1.80569190
140Pancreatic islet-cell hyperplasia (HP:0004510)1.80208765
141Supranuclear gaze palsy (HP:0000605)1.78440125
142Milia (HP:0001056)1.78200538
143Protrusio acetabuli (HP:0003179)1.77385243
144Abnormal umbilical cord blood vessels (HP:0011403)1.75607689
145Single umbilical artery (HP:0001195)1.75607689
146Abnormality of the fetal cardiovascular system (HP:0010948)1.75607689
147Broad distal phalanx of finger (HP:0009836)1.75307069
148Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75168246
149Premature rupture of membranes (HP:0001788)1.74791662
150Squamous cell carcinoma (HP:0002860)1.74689921
151Renovascular hypertension (HP:0100817)1.73094098
152Abnormal respiratory motile cilium physiology (HP:0012261)1.72861956
153Progressive external ophthalmoplegia (HP:0000590)1.72532357
154Distal lower limb muscle weakness (HP:0009053)1.72403454
155Abnormality of the periventricular white matter (HP:0002518)1.71901339
156Flat cornea (HP:0007720)1.71886199
157Neoplasm of the oral cavity (HP:0100649)1.71749239
158Deviation of the thumb (HP:0009603)1.71742394
159Elfin facies (HP:0004428)1.71260996
160Abnormal respiratory epithelium morphology (HP:0012253)1.69542523
161Abnormal respiratory motile cilium morphology (HP:0005938)1.69542523
162Reticulocytosis (HP:0001923)1.69399148
163Abnormal ossification of hand bones (HP:0005921)1.69306202
164Progressive sensorineural hearing impairment (HP:0000408)1.69139828
165Broad phalanges of the hand (HP:0009768)1.69097607
166Renal duplication (HP:0000075)1.68945790
167Elbow flexion contracture (HP:0002987)1.68837715
168Febrile seizures (HP:0002373)1.68548372
169Myopathic facies (HP:0002058)1.68049925
170Diaphragmatic weakness (HP:0009113)1.67589380
171Pseudobulbar signs (HP:0002200)1.67537165
172Proximal placement of thumb (HP:0009623)1.66936709
173Ocular albinism (HP:0001107)1.66803720
174Rough bone trabeculation (HP:0100670)1.66431488
175Absent epiphyses (HP:0010577)1.65481064
176Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.65481064
177Mitral regurgitation (HP:0001653)1.64955288
178Back pain (HP:0003418)1.63034423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.15720345
2DDR24.95545610
3MAPK154.87405159
4SMG14.06496345
5MAP3K63.32502318
6IRAK33.04628888
7TYRO32.94172682
8DAPK12.72506819
9PINK12.70317921
10NME22.66843827
11EPHA22.61888624
12MATK2.56590914
13MAP3K112.47761260
14FGR2.46759039
15UHMK12.38791678
16PRKD22.37641038
17PDGFRA2.14407160
18PKN22.11009694
19MST1R2.02215070
20BMX1.85827354
21DYRK1B1.79503730
22MAP3K91.79140242
23MAP3K101.76509182
24CSK1.70273199
25NTRK31.57613317
26FGFR41.56868176
27CDC42BPA1.55856126
28TRIB31.51436480
29TNIK1.49050524
30TRPM71.45534148
31PHKG11.44908700
32PHKG21.44908700
33EPHA41.39241202
34YES11.30974957
35TESK21.28573484
36PRPF4B1.27912783
37MAP2K31.26847040
38TAOK11.25318960
39SIK21.22015303
40PAK41.17643056
41CDC71.15943287
42MAP2K21.15822125
43PIM21.15396330
44RPS6KL11.11376866
45RPS6KC11.11376866
46PRKD31.08092801
47HIPK21.07525476
48TESK11.06986769
49ARAF1.06621899
50CDK41.04395063
51EEF2K1.02841656
52SCYL21.02631674
53MAP3K31.02429981
54TTN1.01463392
55RIPK10.98308804
56NEK20.98249172
57IRAK20.95147456
58AURKA0.94991365
59CAMK1D0.94048326
60RPS6KA60.93773140
61DAPK20.92982847
62CDK80.92919341
63MARK20.92333629
64MAP3K80.91661935
65CDK60.89399703
66GRK60.88254775
67ILK0.87922162
68BRAF0.86931058
69NTRK20.85132585
70PDPK10.84995924
71TNK20.84504884
72TTK0.83499129
73CDK70.83434381
74MAPK110.83291086
75BUB10.83183600
76KDR0.80179866
77ERN10.78649860
78MTOR0.76279515
79AKT30.75083196
80LRRK20.73831437
81MAP3K130.73530941
82MAP3K20.72205938
83RAF10.70569472
84GSK3A0.67608641
85ATR0.67047836
86BRD40.65209443
87RPS6KA10.62377733
88PTK20.61847608
89LATS20.60586271
90CHEK10.60318201
91IRAK40.59367639
92CAMK1G0.59350432
93TAOK20.59271047
94PAK60.58461072
95MAP4K10.57684179
96NME10.57255817
97PDGFRB0.56881217
98STK380.56343126
99PIM10.54786859
100AKT20.54193344
101TBK10.53427081
102TLK10.52190253
103PRKAA10.51494249
104CDK120.50483938
105MET0.50119732
106PRKCZ0.49569713
107ERBB30.47763013
108MAPKAPK30.47600818
109CAMKK10.47341317
110LMTK20.47070506
111ALK0.46884462
112PTK60.46681492
113AURKB0.46662762
114CDK50.45948314
115BRSK10.45232158
116CAMK2B0.44872843
117RPS6KB20.43183142
118PRKD10.42943842
119MAPK100.42535409
120RPS6KA40.41368663
121SIK10.40867470
122MAP3K70.38369214
123KSR20.38226884
124SGK10.36825309
125DYRK30.36305059
126CDK10.36072348
127STK40.35961446
128PDK10.35020675
129VRK20.34686210
130STK110.34637656
131CDK11A0.34462753
132EGFR0.33574761
133RPS6KB10.32900104
134CDK150.32629156
135MUSK0.32517997
136DMPK0.31743149
137RPS6KA30.31026100
138CCNB10.31006154
139PRKCI0.30961301
140MAP3K10.30677084
141CDK20.29635097
142CDK90.29525347
143PAK10.29108171
144NTRK10.28301040
145CHEK20.28145800
146MAPK30.27533808
147PAK20.27453017
148MAPK10.26971038
149MAPK140.26934065
150CDK180.26885591
151CAMK40.26175270
152KSR10.25137839
153CSNK1G10.24521409
154MAPK90.24215053
155RPS6KA20.24189539
156CAMK2G0.23354905
157INSR0.22814290

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.69797295
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.71190332
3Base excision repair_Homo sapiens_hsa034102.58614931
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.45310552
5Other glycan degradation_Homo sapiens_hsa005112.42324437
6mTOR signaling pathway_Homo sapiens_hsa041502.40465540
7Notch signaling pathway_Homo sapiens_hsa043302.05309704
8Mismatch repair_Homo sapiens_hsa034301.99558347
9Pentose phosphate pathway_Homo sapiens_hsa000301.98708496
10Circadian rhythm_Homo sapiens_hsa047101.91189300
11Olfactory transduction_Homo sapiens_hsa047401.88092728
12Central carbon metabolism in cancer_Homo sapiens_hsa052301.82760227
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.80411096
14Longevity regulating pathway - mammal_Homo sapiens_hsa042111.75087517
15VEGF signaling pathway_Homo sapiens_hsa043701.70205524
16Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.61395880
17Hedgehog signaling pathway_Homo sapiens_hsa043401.59899149
18Gap junction_Homo sapiens_hsa045401.57718907
19Phenylalanine metabolism_Homo sapiens_hsa003601.57281093
20Hippo signaling pathway_Homo sapiens_hsa043901.50410523
21Arginine biosynthesis_Homo sapiens_hsa002201.41958923
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40639177
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.40391505
24Galactose metabolism_Homo sapiens_hsa000521.40094362
25Pancreatic cancer_Homo sapiens_hsa052121.38871849
26GABAergic synapse_Homo sapiens_hsa047271.37262655
27Wnt signaling pathway_Homo sapiens_hsa043101.35579071
28ErbB signaling pathway_Homo sapiens_hsa040121.35028136
29Cell cycle_Homo sapiens_hsa041101.33552915
30GnRH signaling pathway_Homo sapiens_hsa049121.33274891
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30964226
32Glutamatergic synapse_Homo sapiens_hsa047241.27151581
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26332535
34Sulfur relay system_Homo sapiens_hsa041221.26149996
35Choline metabolism in cancer_Homo sapiens_hsa052311.26088273
36DNA replication_Homo sapiens_hsa030301.24304828
37Colorectal cancer_Homo sapiens_hsa052101.24170712
38Long-term potentiation_Homo sapiens_hsa047201.24102738
39Pyrimidine metabolism_Homo sapiens_hsa002401.23447911
40Bladder cancer_Homo sapiens_hsa052191.20025173
41Basal cell carcinoma_Homo sapiens_hsa052171.19298732
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18192239
43Amphetamine addiction_Homo sapiens_hsa050311.16996663
44Circadian entrainment_Homo sapiens_hsa047131.16746292
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16160981
46Nicotine addiction_Homo sapiens_hsa050331.16092348
47Morphine addiction_Homo sapiens_hsa050321.15207963
48Estrogen signaling pathway_Homo sapiens_hsa049151.12618073
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.11547958
50Carbon metabolism_Homo sapiens_hsa012001.11403254
51Aldosterone synthesis and secretion_Homo sapiens_hsa049251.11119951
52Adherens junction_Homo sapiens_hsa045201.10281474
53Chronic myeloid leukemia_Homo sapiens_hsa052201.10138553
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08170402
55Vitamin B6 metabolism_Homo sapiens_hsa007501.07989713
56Lysine degradation_Homo sapiens_hsa003101.06340742
57Salivary secretion_Homo sapiens_hsa049701.06304507
58Nucleotide excision repair_Homo sapiens_hsa034201.05804632
59Endometrial cancer_Homo sapiens_hsa052131.05436374
60Viral carcinogenesis_Homo sapiens_hsa052031.02870376
61Gastric acid secretion_Homo sapiens_hsa049711.02617932
62mRNA surveillance pathway_Homo sapiens_hsa030151.02609162
63Synaptic vesicle cycle_Homo sapiens_hsa047211.02133619
64Insulin secretion_Homo sapiens_hsa049111.00808443
65Acute myeloid leukemia_Homo sapiens_hsa052211.00354499
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97335517
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.97140073
68Small cell lung cancer_Homo sapiens_hsa052220.95182037
69Systemic lupus erythematosus_Homo sapiens_hsa053220.94619893
70Arginine and proline metabolism_Homo sapiens_hsa003300.93465096
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93171209
72Prostate cancer_Homo sapiens_hsa052150.91814261
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91370853
74Shigellosis_Homo sapiens_hsa051310.90534537
75Pancreatic secretion_Homo sapiens_hsa049720.90186893
76Dorso-ventral axis formation_Homo sapiens_hsa043200.89029026
77Insulin signaling pathway_Homo sapiens_hsa049100.87905421
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87714791
79Prion diseases_Homo sapiens_hsa050200.87657938
80Oxytocin signaling pathway_Homo sapiens_hsa049210.86855122
81Glioma_Homo sapiens_hsa052140.86468342
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85879812
83Dopaminergic synapse_Homo sapiens_hsa047280.85426091
84Thyroid cancer_Homo sapiens_hsa052160.85056894
85Taste transduction_Homo sapiens_hsa047420.84948900
86B cell receptor signaling pathway_Homo sapiens_hsa046620.84227969
87Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83662309
88MAPK signaling pathway_Homo sapiens_hsa040100.82854483
89Cholinergic synapse_Homo sapiens_hsa047250.82823750
90Long-term depression_Homo sapiens_hsa047300.80745807
91HTLV-I infection_Homo sapiens_hsa051660.79408279
92Melanogenesis_Homo sapiens_hsa049160.78044503
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77619272
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77513840
95Alcoholism_Homo sapiens_hsa050340.76613065
96Apoptosis_Homo sapiens_hsa042100.75455980
97Oocyte meiosis_Homo sapiens_hsa041140.75093053
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74890078
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.74086336
100Spliceosome_Homo sapiens_hsa030400.72622611
101Tyrosine metabolism_Homo sapiens_hsa003500.70901479
102RNA transport_Homo sapiens_hsa030130.70649306
103Tight junction_Homo sapiens_hsa045300.70138940
104One carbon pool by folate_Homo sapiens_hsa006700.70137689
105Proteoglycans in cancer_Homo sapiens_hsa052050.68246432
106Hepatitis C_Homo sapiens_hsa051600.68024936
107TGF-beta signaling pathway_Homo sapiens_hsa043500.67686335
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67200479
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65808460
110Non-small cell lung cancer_Homo sapiens_hsa052230.65700880
111Primary immunodeficiency_Homo sapiens_hsa053400.64818146
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64758271
113N-Glycan biosynthesis_Homo sapiens_hsa005100.64335259
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63116627
115Endocytosis_Homo sapiens_hsa041440.63106070
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.62955552
117Axon guidance_Homo sapiens_hsa043600.62299899
118Renal cell carcinoma_Homo sapiens_hsa052110.62125275
119Rap1 signaling pathway_Homo sapiens_hsa040150.61735998
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61378126
121Ribosome_Homo sapiens_hsa030100.61027254
122Vibrio cholerae infection_Homo sapiens_hsa051100.60377187
123Calcium signaling pathway_Homo sapiens_hsa040200.59464931
124AMPK signaling pathway_Homo sapiens_hsa041520.59457710
125Focal adhesion_Homo sapiens_hsa045100.59325872
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58779435
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.58374989
128Fructose and mannose metabolism_Homo sapiens_hsa000510.58163029
129Lysosome_Homo sapiens_hsa041420.57833177
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57393069
131Renin secretion_Homo sapiens_hsa049240.57364867
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.57162879
133Hepatitis B_Homo sapiens_hsa051610.56904014
134Inositol phosphate metabolism_Homo sapiens_hsa005620.56054905
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55973166
136Biosynthesis of amino acids_Homo sapiens_hsa012300.55714399
137Adipocytokine signaling pathway_Homo sapiens_hsa049200.55224426
138Type II diabetes mellitus_Homo sapiens_hsa049300.54902114
139Thyroid hormone synthesis_Homo sapiens_hsa049180.54514874
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.54324923
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54039199
142MicroRNAs in cancer_Homo sapiens_hsa052060.53698976
143Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53027721
144Cysteine and methionine metabolism_Homo sapiens_hsa002700.52691370
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49405929
146Non-homologous end-joining_Homo sapiens_hsa034500.48512263
147Sphingolipid signaling pathway_Homo sapiens_hsa040710.47374657
148Insulin resistance_Homo sapiens_hsa049310.44539014
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.43503146
150Glutathione metabolism_Homo sapiens_hsa004800.43231678
151Folate biosynthesis_Homo sapiens_hsa007900.42533262
152Epstein-Barr virus infection_Homo sapiens_hsa051690.40485530

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