LRRC40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.24613030
2protein localization to kinetochore (GO:0034501)4.11000082
3DNA double-strand break processing (GO:0000729)4.08776447
4synapsis (GO:0007129)4.07641934
5DNA damage response, detection of DNA damage (GO:0042769)3.94538083
6mitotic sister chromatid segregation (GO:0000070)3.89095633
7chromatin remodeling at centromere (GO:0031055)3.86065289
8CENP-A containing nucleosome assembly (GO:0034080)3.85309321
9DNA unwinding involved in DNA replication (GO:0006268)3.77092853
10mitotic chromosome condensation (GO:0007076)3.76453297
11kinetochore organization (GO:0051383)3.75045891
12spindle checkpoint (GO:0031577)3.69575791
13DNA replication checkpoint (GO:0000076)3.66349329
14sister chromatid segregation (GO:0000819)3.65003757
15DNA replication initiation (GO:0006270)3.62627886
16metaphase plate congression (GO:0051310)3.62101210
17nuclear pore organization (GO:0006999)3.58136990
18attachment of spindle microtubules to kinetochore (GO:0008608)3.54867363
19negative regulation of mitotic sister chromatid separation (GO:2000816)3.54072224
20negative regulation of mitotic sister chromatid segregation (GO:0033048)3.54072224
21negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.54072224
22negative regulation of sister chromatid segregation (GO:0033046)3.54072224
23negative regulation of chromosome segregation (GO:0051985)3.52051888
24histone exchange (GO:0043486)3.50699130
25spindle assembly checkpoint (GO:0071173)3.49613277
26kinetochore assembly (GO:0051382)3.49466456
27negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.48072186
28mitotic spindle assembly checkpoint (GO:0007094)3.47695098
29mitotic spindle checkpoint (GO:0071174)3.47388993
30DNA replication-independent nucleosome organization (GO:0034724)3.46267953
31DNA replication-independent nucleosome assembly (GO:0006336)3.46267953
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.43545274
33regulation of mitotic spindle checkpoint (GO:1903504)3.43545274
34IMP biosynthetic process (GO:0006188)3.43109736
35mitotic nuclear envelope disassembly (GO:0007077)3.42456404
36protein localization to chromosome, centromeric region (GO:0071459)3.42059862
37resolution of meiotic recombination intermediates (GO:0000712)3.39879189
38negative regulation of DNA recombination (GO:0045910)3.38998438
39establishment of chromosome localization (GO:0051303)3.37212615
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36152216
41replication fork processing (GO:0031297)3.33595777
42DNA strand elongation involved in DNA replication (GO:0006271)3.33146219
43nuclear pore complex assembly (GO:0051292)3.32786798
44regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32597256
45regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28448930
46DNA ligation (GO:0006266)3.28368767
47regulation of mitotic sister chromatid separation (GO:0010965)3.28051080
48regulation of mitotic sister chromatid segregation (GO:0033047)3.28051080
49regulation of sister chromatid segregation (GO:0033045)3.28051080
50regulation of chromosome segregation (GO:0051983)3.26554909
51nuclear envelope disassembly (GO:0051081)3.26052064
52membrane disassembly (GO:0030397)3.26052064
53maturation of 5.8S rRNA (GO:0000460)3.24532559
54regulation of helicase activity (GO:0051095)3.19682952
55neural tube formation (GO:0001841)3.18549416
56DNA replication-dependent nucleosome organization (GO:0034723)3.17777287
57DNA replication-dependent nucleosome assembly (GO:0006335)3.17777287
58DNA strand elongation (GO:0022616)3.16199931
59regulation of centriole replication (GO:0046599)3.14554545
60mitotic sister chromatid cohesion (GO:0007064)3.13452862
61histone mRNA metabolic process (GO:0008334)3.10713210
62axoneme assembly (GO:0035082)3.09241129
63tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.06351738
64RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.06351738
65intra-S DNA damage checkpoint (GO:0031573)3.04968495
66double-strand break repair via nonhomologous end joining (GO:0006303)3.04220711
67non-recombinational repair (GO:0000726)3.04220711
68nucleobase biosynthetic process (GO:0046112)3.02469154
69regulation of centrosome cycle (GO:0046605)3.02283587
70IMP metabolic process (GO:0046040)3.00108738
71microtubule depolymerization (GO:0007019)2.98167560
72regulation of spindle organization (GO:0090224)2.97436546
73pyrimidine nucleobase catabolic process (GO:0006208)2.96097449
74peptidyl-arginine omega-N-methylation (GO:0035247)2.95259891
75L-serine metabolic process (GO:0006563)2.95214728
76chromosome segregation (GO:0007059)2.95133891
77purine nucleobase biosynthetic process (GO:0009113)2.93574169
78presynaptic membrane assembly (GO:0097105)2.91585415
79negative regulation of mitosis (GO:0045839)2.91213348
80ribonucleoprotein complex disassembly (GO:0032988)2.90462105
81organelle disassembly (GO:1903008)2.90001744
82meiotic chromosome segregation (GO:0045132)2.89667419
83piRNA metabolic process (GO:0034587)2.89537124
84telomere maintenance via semi-conservative replication (GO:0032201)2.88086046
85peptidyl-arginine N-methylation (GO:0035246)2.85783233
86peptidyl-arginine methylation (GO:0018216)2.85783233
87RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.82330466
88vocalization behavior (GO:0071625)2.81778042
89histone arginine methylation (GO:0034969)2.81684892
90positive regulation of synapse maturation (GO:0090129)2.79810557
91regulation of double-strand break repair via homologous recombination (GO:0010569)2.78879846
92protein K6-linked ubiquitination (GO:0085020)2.78264188
93regulation of nuclear cell cycle DNA replication (GO:0033262)2.77608323
94maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75076572
95negative regulation of nuclear division (GO:0051784)2.74119814
96sympathetic nervous system development (GO:0048485)2.73379494
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72826960
98ATP-dependent chromatin remodeling (GO:0043044)2.72254896
99synaptic vesicle docking involved in exocytosis (GO:0016081)2.72247200
100spliceosomal complex assembly (GO:0000245)2.71568372
101mitotic recombination (GO:0006312)2.71084808
102regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.69884915
103neuron cell-cell adhesion (GO:0007158)2.69506918
104positive regulation of chromosome segregation (GO:0051984)2.68780871
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.68634404
106chromatin assembly or disassembly (GO:0006333)2.68277399
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68140395
108histone H2A acetylation (GO:0043968)2.67830789
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.67688055
110somatic diversification of immune receptors via somatic mutation (GO:0002566)2.67688055
111negative regulation of translation, ncRNA-mediated (GO:0040033)2.66801912
112regulation of translation, ncRNA-mediated (GO:0045974)2.66801912
113negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66801912
114postreplication repair (GO:0006301)2.66657785
115positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.66007333
116protein localization to chromosome (GO:0034502)2.65880471
117centriole replication (GO:0007099)2.65610453
118protein deneddylation (GO:0000338)2.65257030
119mismatch repair (GO:0006298)2.65079224
120regulation of translational termination (GO:0006449)2.63930042
121protein K11-linked ubiquitination (GO:0070979)2.63164716
122limb bud formation (GO:0060174)2.61928314
123DNA catabolic process, exonucleolytic (GO:0000738)2.60914883
124presynaptic membrane organization (GO:0097090)2.60452965
125negative regulation of histone methylation (GO:0031061)2.60222941
126telomere maintenance via recombination (GO:0000722)2.59697173
127regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.59666895
128cullin deneddylation (GO:0010388)2.59520804
129regulation of meiosis I (GO:0060631)2.59298497
130protein neddylation (GO:0045116)2.58870783
131somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.58077398
132somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.58077398
133isotype switching (GO:0045190)2.58077398
134negative regulation of chromosome organization (GO:2001251)2.56242659
135response to X-ray (GO:0010165)2.56075691
136mitotic cell cycle (GO:0000278)2.55854633
137regulation of DNA endoreduplication (GO:0032875)2.55355602
138telomere maintenance via telomere lengthening (GO:0010833)2.53280086
139deoxyribonucleotide biosynthetic process (GO:0009263)2.52774233
140establishment of integrated proviral latency (GO:0075713)2.52525511
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.52497222
142negative regulation of meiosis (GO:0045835)2.49252122
143recombinational repair (GO:0000725)2.47888640
144proteasome assembly (GO:0043248)2.47547202
145microtubule anchoring (GO:0034453)2.47119778
146double-strand break repair via homologous recombination (GO:0000724)2.46662476
147reciprocal DNA recombination (GO:0035825)2.46224316
148reciprocal meiotic recombination (GO:0007131)2.46224316
149olfactory bulb development (GO:0021772)2.43228967
150regulation of development, heterochronic (GO:0040034)2.42813159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.57822095
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.70940722
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.02193723
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.23694698
5ZNF274_21170338_ChIP-Seq_K562_Hela3.14446870
6* MYC_18555785_ChIP-Seq_MESCs_Mouse3.08479300
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.90341720
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89490108
9EZH2_22144423_ChIP-Seq_EOC_Human2.88512268
10* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.70583634
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.42299441
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39550207
13AR_21909140_ChIP-Seq_LNCAP_Human2.35243217
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34003722
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28277591
16VDR_22108803_ChIP-Seq_LS180_Human2.24946401
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18063555
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.12157867
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.08928460
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.08053444
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07136477
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06017138
23FUS_26573619_Chip-Seq_HEK293_Human1.96619370
24YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93349675
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.86630207
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.81499202
27HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.77433514
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.76028363
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72029820
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71555894
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.71169471
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69998731
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.68911150
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67862908
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67722034
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65652869
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63945415
38* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61402877
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60494412
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60340410
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55785101
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.53385549
43IRF1_19129219_ChIP-ChIP_H3396_Human1.50308688
44XRN2_22483619_ChIP-Seq_HELA_Human1.49500938
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46865675
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46012052
47MYC_18940864_ChIP-ChIP_HL60_Human1.43376334
48* EWS_26573619_Chip-Seq_HEK293_Human1.42790260
49GBX2_23144817_ChIP-Seq_PC3_Human1.41213893
50HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40207699
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39757417
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38127195
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36556665
54TTF2_22483619_ChIP-Seq_HELA_Human1.35735202
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34097857
56* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32454888
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32171209
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31018700
59* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30380266
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28745311
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28444385
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28134503
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26646591
64SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.26572562
65VDR_23849224_ChIP-Seq_CD4+_Human1.25983543
66RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25024973
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24283273
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.23878500
69ER_23166858_ChIP-Seq_MCF-7_Human1.23388567
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23289790
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23082606
72CBP_20019798_ChIP-Seq_JUKART_Human1.22752715
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22752715
74TAF15_26573619_Chip-Seq_HEK293_Human1.22510821
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22010388
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21577774
77GABP_19822575_ChIP-Seq_HepG2_Human1.21030399
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20445720
79ELK1_19687146_ChIP-ChIP_HELA_Human1.20098058
80FOXP3_21729870_ChIP-Seq_TREG_Human1.19978360
81DCP1A_22483619_ChIP-Seq_HELA_Human1.19468600
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.19199267
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.18307205
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.17454134
85ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16865077
86SMAD4_21799915_ChIP-Seq_A2780_Human1.16831895
87NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16760393
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15930542
89SOX2_16153702_ChIP-ChIP_HESCs_Human1.14811224
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14611748
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14031337
92CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.13757261
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.13462246
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13153343
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12992723
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12177258
97* NANOG_18555785_Chip-Seq_ESCs_Mouse1.11983049
98TP63_19390658_ChIP-ChIP_HaCaT_Human1.11423986
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.11284146
100* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09460401
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.08267473
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07833920
103STAT3_23295773_ChIP-Seq_U87_Human1.06621067
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05726659
105EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05691429
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.04548997
107TP53_22573176_ChIP-Seq_HFKS_Human1.03829148
108CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02893686
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02186689
110TCF4_22108803_ChIP-Seq_LS180_Human1.02103323
111TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99715992
112POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99715992
113CIITA_25753668_ChIP-Seq_RAJI_Human0.97496232
114NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96699537
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96601577
116SOX2_19829295_ChIP-Seq_ESCs_Human0.96425303
117NANOG_19829295_ChIP-Seq_ESCs_Human0.96425303
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96138865
119SOX9_26525672_Chip-Seq_HEART_Mouse0.95832257
120RNF2_27304074_Chip-Seq_NSC_Mouse0.95755758
121KDM5A_27292631_Chip-Seq_BREAST_Human0.95593931
122P53_22387025_ChIP-Seq_ESCs_Mouse0.94733579
123PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92887901
124IGF1R_20145208_ChIP-Seq_DFB_Human0.92381201
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.92278423
126GATA1_26923725_Chip-Seq_HPCs_Mouse0.88951454
127P300_19829295_ChIP-Seq_ESCs_Human0.88537699
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87985088
129* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87300454
130SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87036421
131TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86802073
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.86690315
133* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85184071
134REST_21632747_ChIP-Seq_MESCs_Mouse0.84961214
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84629619
136* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82523723
137REST_18959480_ChIP-ChIP_MESCs_Mouse0.81935343
138FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80040278
139ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77748615
140JUN_21703547_ChIP-Seq_K562_Human0.77602144
141YY1_21170310_ChIP-Seq_MESCs_Mouse0.76750166
142* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.76273887
143NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.74661766
144NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74659920
145* NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73196720
146TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.73116046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.73932879
2MP0003123_paternal_imprinting3.56039524
3MP0004859_abnormal_synaptic_plasticity3.52199865
4MP0010094_abnormal_chromosome_stability3.51351984
5MP0003111_abnormal_nucleus_morphology3.15481984
6MP0003693_abnormal_embryo_hatching3.07489832
7MP0004957_abnormal_blastocyst_morpholog2.84104901
8MP0008877_abnormal_DNA_methylation2.75682399
9MP0003077_abnormal_cell_cycle2.54456112
10MP0003121_genomic_imprinting2.36864088
11MP0003787_abnormal_imprinting2.28612639
12MP0003635_abnormal_synaptic_transmissio2.27585465
13MP0006292_abnormal_olfactory_placode2.12439478
14MP0002751_abnormal_autonomic_nervous1.98310732
15MP0002063_abnormal_learning/memory/cond1.97416454
16MP0001188_hyperpigmentation1.92663117
17MP0008058_abnormal_DNA_repair1.91776708
18MP0008932_abnormal_embryonic_tissue1.90620526
19MP0008789_abnormal_olfactory_epithelium1.88743741
20MP0000647_abnormal_sebaceous_gland1.85169644
21MP0001968_abnormal_touch/_nociception1.83427529
22MP0008057_abnormal_DNA_replication1.83331612
23MP0004270_analgesia1.82467207
24MP0009745_abnormal_behavioral_response1.81044206
25MP0004885_abnormal_endolymph1.80908527
26MP0002138_abnormal_hepatobiliary_system1.78695040
27MP0002653_abnormal_ependyma_morphology1.77833787
28MP0003718_maternal_effect1.75624494
29MP0008007_abnormal_cellular_replicative1.74919438
30MP0003567_abnormal_fetal_cardiomyocyte1.74761636
31MP0002102_abnormal_ear_morphology1.72543151
32MP0001529_abnormal_vocalization1.71659704
33MP0001293_anophthalmia1.63953050
34MP0001730_embryonic_growth_arrest1.63038456
35MP0002572_abnormal_emotion/affect_behav1.61975039
36MP0003221_abnormal_cardiomyocyte_apopto1.61121256
37MP0000778_abnormal_nervous_system1.58562298
38MP0002736_abnormal_nociception_after1.57725970
39MP0003890_abnormal_embryonic-extraembry1.56621724
40MP0006072_abnormal_retinal_apoptosis1.56412906
41MP0000427_abnormal_hair_cycle1.49204296
42MP0009697_abnormal_copulation1.46715675
43MP0001348_abnormal_lacrimal_gland1.43468558
44MP0002233_abnormal_nose_morphology1.41407532
45MP0003315_abnormal_perineum_morphology1.40980639
46MP0006035_abnormal_mitochondrial_morpho1.40271811
47MP0000350_abnormal_cell_proliferation1.40203286
48MP0002064_seizures1.38991790
49MP0002085_abnormal_embryonic_tissue1.36942899
50MP0002822_catalepsy1.35839519
51MP0002938_white_spotting1.35547716
52MP0003861_abnormal_nervous_system1.34759153
53MP0002234_abnormal_pharynx_morphology1.33093714
54MP0002210_abnormal_sex_determination1.32497456
55MP0002084_abnormal_developmental_patter1.30994220
56MP0005253_abnormal_eye_physiology1.30178964
57MP0002734_abnormal_mechanical_nocicepti1.28620782
58MP0005551_abnormal_eye_electrophysiolog1.25502862
59MP0001486_abnormal_startle_reflex1.24091346
60MP0001286_abnormal_eye_development1.23212828
61MP0002638_abnormal_pupillary_reflex1.22765727
62MP0001697_abnormal_embryo_size1.22395308
63MP0003195_calcinosis1.20192438
64MP0003119_abnormal_digestive_system1.19428734
65MP0003937_abnormal_limbs/digits/tail_de1.17613919
66MP0005380_embryogenesis_phenotype1.16825429
67MP0001672_abnormal_embryogenesis/_devel1.16825429
68MP0000537_abnormal_urethra_morphology1.14972835
69MP0002184_abnormal_innervation1.14790650
70MP0009046_muscle_twitch1.12873198
71MP0002272_abnormal_nervous_system1.11974155
72MP0001929_abnormal_gametogenesis1.10892202
73MP0002152_abnormal_brain_morphology1.10174788
74MP0008995_early_reproductive_senescence1.09866557
75MP0005075_abnormal_melanosome_morpholog1.07954874
76MP0003122_maternal_imprinting1.06805992
77MP0003755_abnormal_palate_morphology1.06744374
78MP0000383_abnormal_hair_follicle1.06733025
79MP0004147_increased_porphyrin_level1.06628785
80MP0001145_abnormal_male_reproductive1.05779480
81MP0002557_abnormal_social/conspecific_i1.05651385
82MP0004742_abnormal_vestibular_system1.05509411
83MP0000653_abnormal_sex_gland1.05398242
84MP0000569_abnormal_digit_pigmentation1.04447299
85MP0004811_abnormal_neuron_physiology1.04279192
86MP0005367_renal/urinary_system_phenotyp1.01507100
87MP0000516_abnormal_urinary_system1.01507100
88MP0005423_abnormal_somatic_nervous1.00128561
89MP0005386_behavior/neurological_phenoty0.99536427
90MP0004924_abnormal_behavior0.99536427
91MP0002067_abnormal_sensory_capabilities0.99161141
92MP0000631_abnormal_neuroendocrine_gland0.98830587
93MP0002080_prenatal_lethality0.98582568
94MP0010307_abnormal_tumor_latency0.98127004
95MP0000372_irregular_coat_pigmentation0.96336471
96MP0003941_abnormal_skin_development0.95593713
97MP0001177_atelectasis0.94397745
98MP0006276_abnormal_autonomic_nervous0.94387673
99MP0001764_abnormal_homeostasis0.93588164
100MP0005394_taste/olfaction_phenotype0.93343192
101MP0005499_abnormal_olfactory_system0.93343192
102MP0005646_abnormal_pituitary_gland0.92968675
103MP0002160_abnormal_reproductive_system0.91868247
104MP0003786_premature_aging0.91853428
105MP0003938_abnormal_ear_development0.91465980
106MP0003984_embryonic_growth_retardation0.91236395
107MP0002163_abnormal_gland_morphology0.90597308
108MP0010030_abnormal_orbit_morphology0.90484656
109MP0002752_abnormal_somatic_nervous0.89735384
110MP0002088_abnormal_embryonic_growth/wei0.89233607
111MP0002735_abnormal_chemical_nociception0.86863968
112MP0001440_abnormal_grooming_behavior0.85421083
113MP0000049_abnormal_middle_ear0.85235803
114MP0010234_abnormal_vibrissa_follicle0.85115545
115MP0002733_abnormal_thermal_nociception0.84651559
116MP0003698_abnormal_male_reproductive0.84603039
117MP0004133_heterotaxia0.84108182
118MP0001119_abnormal_female_reproductive0.83779396
119MP0002882_abnormal_neuron_morphology0.82952252
120MP0004197_abnormal_fetal_growth/weight/0.82237146
121MP0002086_abnormal_extraembryonic_tissu0.81492791
122MP0004215_abnormal_myocardial_fiber0.81090557
123MP0001485_abnormal_pinna_reflex0.81012607
124MP0002111_abnormal_tail_morphology0.80489249
125MP0001905_abnormal_dopamine_level0.78746659
126MP0003935_abnormal_craniofacial_develop0.78708205
127MP0009672_abnormal_birth_weight0.77895576
128MP0000026_abnormal_inner_ear0.77667632
129MP0005187_abnormal_penis_morphology0.77450344
130MP0005391_vision/eye_phenotype0.77316492
131MP0005389_reproductive_system_phenotype0.76710129
132MP0000955_abnormal_spinal_cord0.76593692
133MP0005084_abnormal_gallbladder_morpholo0.76544879
134MP0002161_abnormal_fertility/fecundity0.76523982
135MP0001984_abnormal_olfaction0.76521331
136MP0001970_abnormal_pain_threshold0.76259841
137MP0002081_perinatal_lethality0.76033420
138MP0003942_abnormal_urinary_system0.75867904
139MP0002127_abnormal_cardiovascular_syste0.74190309
140MP0005195_abnormal_posterior_eye0.73231946

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.21342423
2Focal motor seizures (HP:0011153)3.75432690
3Birth length less than 3rd percentile (HP:0003561)3.75268768
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.52661847
5Abnormality of alanine metabolism (HP:0010916)3.52661847
6Hyperalaninemia (HP:0003348)3.52661847
7Chromsome breakage (HP:0040012)3.12303658
8Ependymoma (HP:0002888)3.10863283
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.04242524
10Patellar aplasia (HP:0006443)2.92312233
11Intestinal atresia (HP:0011100)2.90924013
12Breast hypoplasia (HP:0003187)2.89208974
13Aplasia/Hypoplasia of the patella (HP:0006498)2.81584374
14Dyschromatopsia (HP:0007641)2.73057107
15Hyperventilation (HP:0002883)2.68546167
16Broad-based gait (HP:0002136)2.66688830
17Facial hemangioma (HP:0000329)2.66274060
18Protruding tongue (HP:0010808)2.65069049
19Rhabdomyosarcoma (HP:0002859)2.62350098
20Supernumerary spleens (HP:0009799)2.58955575
21Shawl scrotum (HP:0000049)2.56279892
22Astrocytoma (HP:0009592)2.55694175
23Abnormality of the astrocytes (HP:0100707)2.55694175
24Epileptic encephalopathy (HP:0200134)2.55192706
25Meckel diverticulum (HP:0002245)2.47046131
26Progressive inability to walk (HP:0002505)2.45704844
27Shoulder girdle muscle weakness (HP:0003547)2.44207459
28Central scotoma (HP:0000603)2.42939916
29Excessive salivation (HP:0003781)2.42174509
30Drooling (HP:0002307)2.42174509
31Abnormality of serum amino acid levels (HP:0003112)2.41909244
32Hyperglycinemia (HP:0002154)2.41807501
33Horseshoe kidney (HP:0000085)2.41787685
34Pancreatic cysts (HP:0001737)2.41700305
35Increased serum pyruvate (HP:0003542)2.41351852
36Abnormality of chromosome stability (HP:0003220)2.40541654
37Aplasia/Hypoplasia of the sternum (HP:0006714)2.39257171
38Congenital primary aphakia (HP:0007707)2.36371735
39Abnormality of the renal cortex (HP:0011035)2.33485334
40Methylmalonic acidemia (HP:0002912)2.32982654
41Abnormal lung lobation (HP:0002101)2.32392143
42Absent radius (HP:0003974)2.31995343
43Abnormality of the ileum (HP:0001549)2.30502453
44Abnormality of the lower motor neuron (HP:0002366)2.29540893
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.26695709
46Medulloblastoma (HP:0002885)2.26575025
47Pancreatic fibrosis (HP:0100732)2.26391685
48Agnosia (HP:0010524)2.22527113
49Cortical dysplasia (HP:0002539)2.21879861
50Volvulus (HP:0002580)2.21837168
51Papillary thyroid carcinoma (HP:0002895)2.20704942
52Focal seizures (HP:0007359)2.20267412
53Abnormality of the preputium (HP:0100587)2.19585468
54Aplasia involving forearm bones (HP:0009822)2.19471390
55Absent forearm bone (HP:0003953)2.19471390
56Abnormality of glycolysis (HP:0004366)2.16960519
57High anterior hairline (HP:0009890)2.16276280
58Constricted visual fields (HP:0001133)2.12533087
59Septate vagina (HP:0001153)2.11508813
60Genital tract atresia (HP:0001827)2.11370739
61Duodenal stenosis (HP:0100867)2.11207358
62Small intestinal stenosis (HP:0012848)2.11207358
63True hermaphroditism (HP:0010459)2.10642105
64Nephrogenic diabetes insipidus (HP:0009806)2.10400150
65Nephroblastoma (Wilms tumor) (HP:0002667)2.09760020
66Myokymia (HP:0002411)2.08159601
67Abnormality of midbrain morphology (HP:0002418)2.07863000
68Molar tooth sign on MRI (HP:0002419)2.07863000
69Glioma (HP:0009733)2.07117314
70Embryonal renal neoplasm (HP:0011794)2.06363665
71Vaginal atresia (HP:0000148)2.06169194
72Abnormality of methionine metabolism (HP:0010901)2.05326462
73Colon cancer (HP:0003003)2.03889211
74Impaired vibration sensation in the lower limbs (HP:0002166)2.03386940
75Breast aplasia (HP:0100783)2.02930881
76Carpal bone hypoplasia (HP:0001498)2.02924221
77Febrile seizures (HP:0002373)1.98305006
78Atonic seizures (HP:0010819)1.97294912
79Poor eye contact (HP:0000817)1.95904660
80Neoplasm of striated muscle (HP:0009728)1.95150975
81Absence seizures (HP:0002121)1.93954725
82Absent speech (HP:0001344)1.93830922
83Gonadotropin excess (HP:0000837)1.93720428
84Hypoplasia of the uterus (HP:0000013)1.93244190
85Aplasia/Hypoplasia of the breasts (HP:0010311)1.91929232
86Degeneration of anterior horn cells (HP:0002398)1.91637982
87Abnormality of the anterior horn cell (HP:0006802)1.91637982
88Abnormality of aspartate family amino acid metabolism (HP:0010899)1.91080713
89Abnormality of the renal medulla (HP:0100957)1.87956594
90Progressive cerebellar ataxia (HP:0002073)1.85996845
91Abnormality of chromosome segregation (HP:0002916)1.84955042
92Nephronophthisis (HP:0000090)1.84624143
93Acute necrotizing encephalopathy (HP:0006965)1.84439643
94Aplasia/hypoplasia of the uterus (HP:0008684)1.83717782
95Acute encephalopathy (HP:0006846)1.82683082
96Impulsivity (HP:0100710)1.82321612
97Hypoplastic pelvis (HP:0008839)1.80843439
98Gastrointestinal atresia (HP:0002589)1.80665517
99Urinary bladder sphincter dysfunction (HP:0002839)1.79168660
100Bifid tongue (HP:0010297)1.78192696
101Inability to walk (HP:0002540)1.77919178
102Abnormality of the duodenum (HP:0002246)1.77903006
103Fair hair (HP:0002286)1.77743623
104Impaired smooth pursuit (HP:0007772)1.77463935
105Scotoma (HP:0000575)1.74849643
106Atrophy/Degeneration involving motor neurons (HP:0007373)1.74616307
107Optic nerve hypoplasia (HP:0000609)1.74567122
108Abolished electroretinogram (ERG) (HP:0000550)1.74336061
109Abnormal hair whorl (HP:0010721)1.74230222
110Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.72925569
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.72925569
112Increased CSF lactate (HP:0002490)1.72911212
113Postaxial hand polydactyly (HP:0001162)1.71755101
114Stenosis of the external auditory canal (HP:0000402)1.70500352
115Renal cortical cysts (HP:0000803)1.70445177
116Ectopic kidney (HP:0000086)1.70277146
117Poor coordination (HP:0002370)1.70227593
118Increased serum lactate (HP:0002151)1.69699721
119Oligodactyly (HP:0012165)1.69416006
120Preaxial hand polydactyly (HP:0001177)1.68782657
121Neoplasm of the adrenal gland (HP:0100631)1.68605106
122Dandy-Walker malformation (HP:0001305)1.68378261
123Septo-optic dysplasia (HP:0100842)1.67870377
124Sclerocornea (HP:0000647)1.66951645
125Oral leukoplakia (HP:0002745)1.66663444
126Gastroesophageal reflux (HP:0002020)1.66192291
127Gaze-evoked nystagmus (HP:0000640)1.66179305
128Postaxial foot polydactyly (HP:0001830)1.65776004
129Chronic hepatic failure (HP:0100626)1.64912148
130Unsteady gait (HP:0002317)1.64200664
131Sloping forehead (HP:0000340)1.63853609
132Small hand (HP:0200055)1.63846361
133Cafe-au-lait spot (HP:0000957)1.63138785
134Dialeptic seizures (HP:0011146)1.62682678
135Medial flaring of the eyebrow (HP:0010747)1.62366728
136Neoplasm of the colon (HP:0100273)1.62119031
137Pelvic girdle muscle weakness (HP:0003749)1.62020825
138Congenital stationary night blindness (HP:0007642)1.61920183
139Neoplasm of the adrenal cortex (HP:0100641)1.61893992
140Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61184291
141Ankle clonus (HP:0011448)1.60634998
142Myelodysplasia (HP:0002863)1.60190184
143Postnatal microcephaly (HP:0005484)1.59396503
144Increased nuchal translucency (HP:0010880)1.58565016
145Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.58167603
146Triphalangeal thumb (HP:0001199)1.57162699
147Oligodactyly (hands) (HP:0001180)1.56080831
148Abnormality of the carotid arteries (HP:0005344)1.55824796
149Abnormality of ocular smooth pursuit (HP:0000617)1.55282808
150Short thumb (HP:0009778)1.55023963
151Sandal gap (HP:0001852)1.54929117
152Deep palmar crease (HP:0006191)1.53028241
153Pointed chin (HP:0000307)1.52388302
154Capillary hemangiomas (HP:0005306)1.51950940
155Gait imbalance (HP:0002141)1.51824293
156Selective tooth agenesis (HP:0001592)1.51472653
157Cerebral hypomyelination (HP:0006808)1.50819700
158Abnormality of the phalanges of the hallux (HP:0010057)1.48997467
159Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.48326718
160Neuroblastoma (HP:0003006)1.48326718
161Primitive neuroectodermal tumor (HP:0030065)1.48326718
162Neuroblastic tumors (HP:0004376)1.48326718

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.63946042
2EPHA43.57920503
3TRIM283.47238979
4CASK2.88325295
5BUB12.79049783
6WEE12.78945838
7WNK32.72397049
8MAP4K22.55623088
9NTRK32.42878287
10SRPK12.40954973
11EIF2AK12.26261038
12CCNB12.25725135
13PLK32.17873566
14PBK2.08904258
15ZAK2.02023136
16TTK1.95726207
17PLK21.95070284
18MAP3K41.92387735
19TSSK61.90035236
20NUAK11.89355763
21KSR11.85689515
22BMPR1B1.85650285
23NEK11.83759539
24MAP3K91.83347196
25FRK1.82864283
26PNCK1.81530250
27PLK11.80175716
28PLK41.79764389
29BRSK21.76020439
30BRSK11.67235047
31LATS21.66788820
32MKNK21.58581629
33MKNK11.55542892
34BRAF1.54866343
35AKT31.51654774
36MAP2K71.46697265
37TNIK1.46421980
38NEK21.44897002
39CSNK1G11.38008673
40DAPK11.36645167
41TLK11.36577886
42VRK11.36444641
43CHEK21.36134764
44CSNK1G21.34574022
45MINK11.32735293
46KSR21.28921276
47MAP3K81.28055005
48PAK61.27921274
49CSNK1G31.26294812
50MARK11.24844343
51TAF11.14059367
52STK38L1.13308702
53OXSR11.13290263
54MAPK131.11645750
55CSNK1A1L1.10427823
56AURKA1.06320697
57CHEK11.05565955
58ATR1.05270107
59DAPK21.00438737
60SIK30.99429126
61MST40.98624366
62RAF10.96747671
63ACVR1B0.95297232
64AURKB0.94832524
65DYRK30.94778162
66PDK20.89956147
67NTRK20.89406082
68UHMK10.89125444
69TGFBR10.83912544
70SGK20.83739595
71BMPR20.81314070
72VRK20.78881542
73PRKD30.78103578
74ATM0.77818445
75GRK10.77417503
76TIE10.76603909
77CDK180.76039709
78CDK120.73864150
79CDK10.73718032
80MAP3K60.73238797
81CDK20.72904472
82PRKCG0.72659436
83ADRBK20.71032984
84CDK150.70761534
85BRD40.70516013
86CDK70.68942592
87PASK0.68840285
88EIF2AK20.68251816
89CDK140.68107130
90CDK40.67939767
91NME10.67271483
92EIF2AK30.66379854
93CDK190.66253385
94NLK0.65301178
95PRKCE0.64862624
96CDK80.64456795
97PAK30.63505559
98RPS6KA40.63435829
99CDK11A0.62929816
100MAP2K40.61919647
101YES10.56236403
102STK390.54881959
103CSNK1E0.54265328
104MELK0.52907391
105ERBB40.52529302
106ERBB30.52369615
107DYRK1A0.52322044
108FGFR10.52101293
109LATS10.51385521
110TAOK20.51275269
111PRKCI0.51240393
112MAP3K120.49868208
113MAP3K50.49646298
114CDK50.49344318
115FLT30.48510037
116STK160.48246265
117DYRK20.48206689
118BCR0.47174701
119SIK20.46502711
120EEF2K0.46247300
121SGK4940.44943312
122SGK2230.44943312
123MAPK100.42452352
124RPS6KB20.41070258
125PINK10.41043447
126DYRK1B0.41001679
127INSRR0.40731222
128ALK0.39497099
129CDK30.38690927
130PAK10.38289278
131CAMK2A0.37788458
132CSNK2A20.37031940
133MAP3K130.36663560
134STK30.36638759
135PRPF4B0.36406118
136CSNK2A10.36050101
137SGK10.35974672
138TAOK10.35864978
139CSNK1D0.35766381
140CAMK2B0.35464450
141PDK40.34018722
142PDK30.34018722
143PKN10.33342328
144CSNK1A10.32967462
145PRKG10.31733042
146CDK90.31013121

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.58168808
2Mismatch repair_Homo sapiens_hsa034303.46967815
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.05929121
4Cell cycle_Homo sapiens_hsa041102.94639194
5RNA transport_Homo sapiens_hsa030132.79549857
6Nicotine addiction_Homo sapiens_hsa050332.79265476
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.64862175
8Protein export_Homo sapiens_hsa030602.62118695
9Spliceosome_Homo sapiens_hsa030402.56478481
10Propanoate metabolism_Homo sapiens_hsa006402.56304874
11Oocyte meiosis_Homo sapiens_hsa041142.55011547
12RNA polymerase_Homo sapiens_hsa030202.50213628
13Homologous recombination_Homo sapiens_hsa034402.47191436
14Steroid biosynthesis_Homo sapiens_hsa001002.46535857
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.41382060
16Nucleotide excision repair_Homo sapiens_hsa034202.26832629
17Fanconi anemia pathway_Homo sapiens_hsa034602.13347336
18Base excision repair_Homo sapiens_hsa034102.06199116
19Long-term potentiation_Homo sapiens_hsa047202.02970531
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98332083
21mRNA surveillance pathway_Homo sapiens_hsa030151.98294557
22Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.97719634
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85548522
24Basal transcription factors_Homo sapiens_hsa030221.84918975
25RNA degradation_Homo sapiens_hsa030181.82278211
26One carbon pool by folate_Homo sapiens_hsa006701.81989545
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.71880180
28Proteasome_Homo sapiens_hsa030501.70632411
29Oxidative phosphorylation_Homo sapiens_hsa001901.68834285
30Amphetamine addiction_Homo sapiens_hsa050311.66429337
31Selenocompound metabolism_Homo sapiens_hsa004501.63591854
32Parkinsons disease_Homo sapiens_hsa050121.57887309
33Butanoate metabolism_Homo sapiens_hsa006501.56013554
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54799445
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.50436063
36Pyruvate metabolism_Homo sapiens_hsa006201.49617430
37Pyrimidine metabolism_Homo sapiens_hsa002401.49054763
38Non-homologous end-joining_Homo sapiens_hsa034501.46072198
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42171826
40Glutamatergic synapse_Homo sapiens_hsa047241.41385008
41Olfactory transduction_Homo sapiens_hsa047401.39266912
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.39237512
43Dopaminergic synapse_Homo sapiens_hsa047281.35341053
44Synaptic vesicle cycle_Homo sapiens_hsa047211.34862114
45Circadian entrainment_Homo sapiens_hsa047131.30502835
46Morphine addiction_Homo sapiens_hsa050321.30448844
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27102653
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26517352
49Alcoholism_Homo sapiens_hsa050341.25662160
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21175255
51Long-term depression_Homo sapiens_hsa047301.20285349
52GABAergic synapse_Homo sapiens_hsa047271.16716727
53Purine metabolism_Homo sapiens_hsa002301.15791647
54Caffeine metabolism_Homo sapiens_hsa002321.09693045
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06649525
56p53 signaling pathway_Homo sapiens_hsa041151.02769153
57Serotonergic synapse_Homo sapiens_hsa047260.98094015
58Taste transduction_Homo sapiens_hsa047420.97172906
59Systemic lupus erythematosus_Homo sapiens_hsa053220.94468556
60Nitrogen metabolism_Homo sapiens_hsa009100.93281554
61Gap junction_Homo sapiens_hsa045400.85834609
62Oxytocin signaling pathway_Homo sapiens_hsa049210.84467833
63Thyroid cancer_Homo sapiens_hsa052160.81988873
64Glioma_Homo sapiens_hsa052140.80578694
65Melanogenesis_Homo sapiens_hsa049160.80514424
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79514239
67Hippo signaling pathway_Homo sapiens_hsa043900.78376411
68Epstein-Barr virus infection_Homo sapiens_hsa051690.78184341
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77311216
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77247919
71Cocaine addiction_Homo sapiens_hsa050300.76304630
72Cysteine and methionine metabolism_Homo sapiens_hsa002700.76045626
73Alzheimers disease_Homo sapiens_hsa050100.75843026
74GnRH signaling pathway_Homo sapiens_hsa049120.75827200
75Vitamin B6 metabolism_Homo sapiens_hsa007500.75643284
76Carbon metabolism_Homo sapiens_hsa012000.73933708
77Wnt signaling pathway_Homo sapiens_hsa043100.73609734
78Cholinergic synapse_Homo sapiens_hsa047250.70966202
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70750443
80Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69494226
81MicroRNAs in cancer_Homo sapiens_hsa052060.68227392
82Fatty acid elongation_Homo sapiens_hsa000620.67720788
83Ether lipid metabolism_Homo sapiens_hsa005650.66867606
84ErbB signaling pathway_Homo sapiens_hsa040120.66783796
85Salivary secretion_Homo sapiens_hsa049700.66475028
86Calcium signaling pathway_Homo sapiens_hsa040200.66043793
87Ribosome_Homo sapiens_hsa030100.66004430
88Colorectal cancer_Homo sapiens_hsa052100.65753050
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65100927
90Axon guidance_Homo sapiens_hsa043600.64427760
91HTLV-I infection_Homo sapiens_hsa051660.62553634
92Phototransduction_Homo sapiens_hsa047440.61891108
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61880644
94Metabolic pathways_Homo sapiens_hsa011000.60700534
95Estrogen signaling pathway_Homo sapiens_hsa049150.60092355
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59948025
97Peroxisome_Homo sapiens_hsa041460.58227356
98Non-small cell lung cancer_Homo sapiens_hsa052230.57311535
99Basal cell carcinoma_Homo sapiens_hsa052170.56551587
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56062850
101Biosynthesis of amino acids_Homo sapiens_hsa012300.55943408
102Insulin secretion_Homo sapiens_hsa049110.55224550
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55204238
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53527399
105Viral carcinogenesis_Homo sapiens_hsa052030.53302428
106Hedgehog signaling pathway_Homo sapiens_hsa043400.52384153
107Renin secretion_Homo sapiens_hsa049240.50761555
108Gastric acid secretion_Homo sapiens_hsa049710.50650430
109cAMP signaling pathway_Homo sapiens_hsa040240.46438783
110mTOR signaling pathway_Homo sapiens_hsa041500.45815661
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45467825
112MAPK signaling pathway_Homo sapiens_hsa040100.44973695
113TGF-beta signaling pathway_Homo sapiens_hsa043500.44302011
114Endometrial cancer_Homo sapiens_hsa052130.43106190
115Bladder cancer_Homo sapiens_hsa052190.42918367
116Huntingtons disease_Homo sapiens_hsa050160.42556938
117Sulfur metabolism_Homo sapiens_hsa009200.42428850
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42263860
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41871505
120Circadian rhythm_Homo sapiens_hsa047100.41460545
121Fatty acid metabolism_Homo sapiens_hsa012120.40924302
122Retinol metabolism_Homo sapiens_hsa008300.40803745
123Tryptophan metabolism_Homo sapiens_hsa003800.39835664
124beta-Alanine metabolism_Homo sapiens_hsa004100.39638934
125Linoleic acid metabolism_Homo sapiens_hsa005910.38163698
126Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38138341
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.36955271
128Melanoma_Homo sapiens_hsa052180.36537933
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.35219584
130cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35214915
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34556871
132Lysine degradation_Homo sapiens_hsa003100.34409196
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.33712296
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33321052
135Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33178794
136Dorso-ventral axis formation_Homo sapiens_hsa043200.32883017
137Cardiac muscle contraction_Homo sapiens_hsa042600.32603813
138Fatty acid biosynthesis_Homo sapiens_hsa000610.31136983
139Choline metabolism in cancer_Homo sapiens_hsa052310.30914307
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30226549
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29677099
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.29613319
143Renal cell carcinoma_Homo sapiens_hsa052110.29095176
144Regulation of autophagy_Homo sapiens_hsa041400.26950075
145FoxO signaling pathway_Homo sapiens_hsa040680.26310315
146Cyanoamino acid metabolism_Homo sapiens_hsa004600.26025857
147Ras signaling pathway_Homo sapiens_hsa040140.25774720
148Rap1 signaling pathway_Homo sapiens_hsa040150.25334076
149Glucagon signaling pathway_Homo sapiens_hsa049220.25086029
150Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24374917

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