LRRC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.04822692
2locomotory exploration behavior (GO:0035641)5.97942841
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.89263808
4axonemal dynein complex assembly (GO:0070286)5.78816927
5vocalization behavior (GO:0071625)5.75082474
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.55173743
7glutamate secretion (GO:0014047)5.44600577
8synaptic vesicle maturation (GO:0016188)5.41814212
9synaptic vesicle exocytosis (GO:0016079)5.27205989
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.17638744
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.14053250
12regulation of glutamate receptor signaling pathway (GO:1900449)5.10395674
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.10157613
14cilium or flagellum-dependent cell motility (GO:0001539)5.08807920
15neuron cell-cell adhesion (GO:0007158)4.99723356
16neuronal action potential propagation (GO:0019227)4.99121626
17regulation of synaptic vesicle exocytosis (GO:2000300)4.94626182
18neurotransmitter-gated ion channel clustering (GO:0072578)4.93211265
19protein localization to synapse (GO:0035418)4.91569789
20exploration behavior (GO:0035640)4.66760474
21glutamate receptor signaling pathway (GO:0007215)4.62575412
22cilium movement (GO:0003341)4.60885398
23synaptic transmission, glutamatergic (GO:0035249)4.58419409
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.52388693
25regulation of neuronal synaptic plasticity (GO:0048168)4.48097906
26regulation of long-term neuronal synaptic plasticity (GO:0048169)4.44862486
27regulation of synaptic vesicle transport (GO:1902803)4.39639303
28neurotransmitter secretion (GO:0007269)4.36031042
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.34002557
30neuron-neuron synaptic transmission (GO:0007270)4.30176206
31dendritic spine morphogenesis (GO:0060997)4.19033297
32negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.12733307
33regulation of excitatory postsynaptic membrane potential (GO:0060079)4.07831815
34gamma-aminobutyric acid transport (GO:0015812)4.02363422
35long-term memory (GO:0007616)4.00006681
36presynaptic membrane assembly (GO:0097105)3.96095912
37positive regulation of synapse maturation (GO:0090129)3.94866432
38positive regulation of membrane potential (GO:0045838)3.94096230
39epithelial cilium movement (GO:0003351)3.92504059
40layer formation in cerebral cortex (GO:0021819)3.92068266
41gamma-aminobutyric acid signaling pathway (GO:0007214)3.87402523
42negative regulation of synaptic transmission, GABAergic (GO:0032229)3.86601609
43regulation of postsynaptic membrane potential (GO:0060078)3.86336585
44long-term synaptic potentiation (GO:0060291)3.85855327
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.80187306
46regulation of synaptic plasticity (GO:0048167)3.78926904
47regulation of synapse structural plasticity (GO:0051823)3.77319570
48presynaptic membrane organization (GO:0097090)3.77080591
49neuron recognition (GO:0008038)3.74341713
50regulation of dendritic spine morphogenesis (GO:0061001)3.73903525
51cerebellar granule cell differentiation (GO:0021707)3.72316491
52postsynaptic membrane organization (GO:0001941)3.71956691
53motile cilium assembly (GO:0044458)3.69613694
54positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68161655
55cellular potassium ion homeostasis (GO:0030007)3.61916313
56transmission of nerve impulse (GO:0019226)3.57318132
57synaptic vesicle endocytosis (GO:0048488)3.57163711
58regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56544755
59regulation of synaptic transmission, glutamatergic (GO:0051966)3.54969663
60neurotransmitter transport (GO:0006836)3.53420765
61positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.49211486
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.49090007
63regulation of neurotransmitter secretion (GO:0046928)3.45509548
64cerebellar Purkinje cell differentiation (GO:0021702)3.44527527
65axonal fasciculation (GO:0007413)3.41842204
66regulation of ARF protein signal transduction (GO:0032012)3.37390358
67auditory behavior (GO:0031223)3.32468706
68neuromuscular process controlling balance (GO:0050885)3.32455998
69amino acid import (GO:0043090)3.30664007
70proline transport (GO:0015824)3.30656992
71response to histamine (GO:0034776)3.27950364
72regulation of neurotransmitter levels (GO:0001505)3.26358696
73L-amino acid import (GO:0043092)3.26228677
74regulation of dendritic spine development (GO:0060998)3.25437388
75positive regulation of neurotransmitter secretion (GO:0001956)3.24666452
76membrane depolarization (GO:0051899)3.24175772
77regulation of vesicle fusion (GO:0031338)3.21391752
78regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.21346482
79dendrite morphogenesis (GO:0048813)3.19118997
80dendritic spine organization (GO:0097061)3.19105496
81behavioral fear response (GO:0001662)3.18079353
82behavioral defense response (GO:0002209)3.18079353
83regulation of synapse maturation (GO:0090128)3.17782201
84response to auditory stimulus (GO:0010996)3.17007864
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.16860833
86learning (GO:0007612)3.16356484
87regulation of neurotransmitter transport (GO:0051588)3.14568866
88negative regulation of immunoglobulin mediated immune response (GO:0002890)3.12310567
89negative regulation of B cell mediated immunity (GO:0002713)3.12310567
90membrane hyperpolarization (GO:0060081)3.11662067
91sodium ion export (GO:0071436)3.11224615
92positive regulation of synaptic transmission (GO:0050806)3.11014619
93central nervous system myelination (GO:0022010)3.10783828
94axon ensheathment in central nervous system (GO:0032291)3.10783828
95negative regulation of inclusion body assembly (GO:0090084)3.10313123
96positive regulation of dendritic spine development (GO:0060999)3.10220063
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09887167
98activation of protein kinase A activity (GO:0034199)3.09807392
99negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09506374
100regulation of synaptic transmission (GO:0050804)3.09197957
101positive regulation of neurotransmitter transport (GO:0051590)3.03913630
102axoneme assembly (GO:0035082)3.03637532
103potassium ion import (GO:0010107)3.02847574
104fear response (GO:0042596)3.01120254
105synapse assembly (GO:0007416)3.00943696
106synaptic transmission (GO:0007268)3.00102512
107innervation (GO:0060384)3.00042334
108regulation of voltage-gated calcium channel activity (GO:1901385)2.99257360
109positive regulation of dendritic spine morphogenesis (GO:0061003)2.99127517
110neuronal ion channel clustering (GO:0045161)2.99100474
111startle response (GO:0001964)2.98903242
112mechanosensory behavior (GO:0007638)2.98327214
113membrane depolarization during action potential (GO:0086010)2.98287024
114positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98186930
115neuromuscular process (GO:0050905)2.94710385
116adult walking behavior (GO:0007628)2.94633527
117peptidyl-tyrosine autophosphorylation (GO:0038083)2.94271547
118long term synaptic depression (GO:0060292)2.92457361
119cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85376985
120potassium ion homeostasis (GO:0055075)2.84640071
121regulation of neuron projection regeneration (GO:0070570)2.79418500
122regulation of axon regeneration (GO:0048679)2.79418500
123positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75260955
124negative regulation of dendrite morphogenesis (GO:0050774)2.71106122
125regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69901562
126phosphorelay signal transduction system (GO:0000160)2.67316203
127negative regulation of cell killing (GO:0031342)2.67289434
128negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67289434
129ventricular system development (GO:0021591)2.65501063
130regulation of beta-amyloid formation (GO:1902003)2.64438074
131regulation of exocytosis (GO:0017157)2.63731238
132microtubule bundle formation (GO:0001578)2.60821174
133leukocyte migration involved in inflammatory response (GO:0002523)2.60551264
134cell differentiation in hindbrain (GO:0021533)2.58035394
135macrophage activation involved in immune response (GO:0002281)2.57281558

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.94729411
2GBX2_23144817_ChIP-Seq_PC3_Human3.85329213
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12626456
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11483173
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.03800795
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70003270
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70003270
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.65007573
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60385633
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58356884
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52060477
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.50067516
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.49298035
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47644817
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43874262
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42831847
17DROSHA_22980978_ChIP-Seq_HELA_Human2.37992743
18* EED_16625203_ChIP-ChIP_MESCs_Mouse2.27139394
19RNF2_27304074_Chip-Seq_ESCs_Mouse2.23215739
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19480714
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18771583
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.17729929
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.13267290
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95452258
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93772025
26AR_21572438_ChIP-Seq_LNCaP_Human1.92317314
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.89758356
28TAF15_26573619_Chip-Seq_HEK293_Human1.86976151
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85549784
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82006540
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81394661
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80395699
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.73210772
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.71847043
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61122043
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.59608290
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58418560
38P300_19829295_ChIP-Seq_ESCs_Human1.51995379
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51408436
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44242561
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.41796452
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38864983
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38488104
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.38466885
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.37239861
46KDM2B_26808549_Chip-Seq_K562_Human1.36749439
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34703129
48ZNF274_21170338_ChIP-Seq_K562_Hela1.34376460
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.34280765
50* ERG_21242973_ChIP-ChIP_JURKAT_Human1.33160612
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32374233
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31999261
53AR_25329375_ChIP-Seq_VCAP_Human1.31996832
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31386711
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30584630
56STAT3_23295773_ChIP-Seq_U87_Human1.30559119
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28503165
58* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26711870
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26667980
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.26529141
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26006235
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21520610
63FUS_26573619_Chip-Seq_HEK293_Human1.21320992
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21138223
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20845265
66* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20178373
67AR_19668381_ChIP-Seq_PC3_Human1.18843372
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18312636
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17686906
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17063127
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16574807
72TCF4_23295773_ChIP-Seq_U87_Human1.15806988
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14571795
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.13761704
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13432761
76GATA1_26923725_Chip-Seq_HPCs_Mouse1.13378923
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12796992
78TP53_16413492_ChIP-PET_HCT116_Human1.11765024
79* RNF2_27304074_Chip-Seq_NSC_Mouse1.09316795
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08844536
81* RING1B_27294783_Chip-Seq_NPCs_Mouse1.08735590
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06707973
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05823031
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05644478
85AHR_22903824_ChIP-Seq_MCF-7_Human1.05428607
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.05288354
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05076522
88IGF1R_20145208_ChIP-Seq_DFB_Human1.04586575
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03496903
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02870877
91RUNX2_22187159_ChIP-Seq_PCA_Human1.02457328
92PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01982994
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01609232
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01084172
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00341292
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00024446
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99935643
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99935643
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.99882826
100DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99128330
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99128057
102* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98718699
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97936134
104* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97202406
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.95569790
106CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95554686
107KLF4_19829295_ChIP-Seq_ESCs_Human0.95043654
108ER_23166858_ChIP-Seq_MCF-7_Human0.94717027
109TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93687586
110EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93107864
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92977404
112SMAD3_21741376_ChIP-Seq_HESCs_Human0.91680223
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.91337595
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.91307523
115RXR_22108803_ChIP-Seq_LS180_Human0.91042054
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.89531728
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89473600
118STAT3_18555785_ChIP-Seq_MESCs_Mouse0.89011343
119* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88478227
120TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88157850
121STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86077686
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85070320
123SPI1_23127762_ChIP-Seq_K562_Human0.83515735
124OCT4_19829295_ChIP-Seq_ESCs_Human0.82869921
125* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81792938
126DPY_21335234_ChIP-Seq_ESCs_Mouse0.81523633
127KDM2B_26808549_Chip-Seq_JURKAT_Human0.81273318

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.84939377
2MP0003880_abnormal_central_pattern5.29952593
3MP0003635_abnormal_synaptic_transmissio4.27096191
4MP0004270_analgesia3.74697319
5MP0009745_abnormal_behavioral_response3.55720937
6MP0002063_abnormal_learning/memory/cond3.45387198
7MP0002064_seizures3.33001220
8MP0009046_muscle_twitch3.20577130
9MP0001968_abnormal_touch/_nociception2.96352591
10MP0002572_abnormal_emotion/affect_behav2.93911710
11MP0005423_abnormal_somatic_nervous2.81784544
12MP0002272_abnormal_nervous_system2.71125642
13* MP0001486_abnormal_startle_reflex2.64055770
14MP0002734_abnormal_mechanical_nocicepti2.56367278
15MP0002736_abnormal_nociception_after2.37752763
16MP0002822_catalepsy2.29408105
17MP0001501_abnormal_sleep_pattern2.28716853
18MP0001440_abnormal_grooming_behavior2.21455274
19MP0002735_abnormal_chemical_nociception2.18911459
20MP0002067_abnormal_sensory_capabilities2.07441628
21MP0000778_abnormal_nervous_system2.00713127
22MP0000566_synostosis1.98628617
23MP0008569_lethality_at_weaning1.95867163
24MP0009780_abnormal_chondrocyte_physiolo1.95804934
25MP0003303_peritoneal_inflammation1.91517604
26MP0003724_increased_susceptibility_to1.86706709
27MP0003329_amyloid_beta_deposits1.86284071
28MP0002277_abnormal_respiratory_mucosa1.84564857
29MP0002733_abnormal_thermal_nociception1.83202666
30MP0001970_abnormal_pain_threshold1.82998994
31MP0002184_abnormal_innervation1.81523116
32MP0002557_abnormal_social/conspecific_i1.76570121
33MP0004924_abnormal_behavior1.72254259
34MP0005386_behavior/neurological_phenoty1.72254259
35MP0004811_abnormal_neuron_physiology1.65457441
36MP0005646_abnormal_pituitary_gland1.64676410
37MP0000955_abnormal_spinal_cord1.62452925
38MP0003787_abnormal_imprinting1.62405522
39MP0003879_abnormal_hair_cell1.58407582
40MP0004858_abnormal_nervous_system1.54185535
41MP0004885_abnormal_endolymph1.51996505
42MP0002882_abnormal_neuron_morphology1.46195229
43* MP0002066_abnormal_motor_capabilities/c1.45210133
44MP0001984_abnormal_olfaction1.45101059
45MP0001529_abnormal_vocalization1.38877535
46MP0005167_abnormal_blood-brain_barrier1.32641225
47MP0001502_abnormal_circadian_rhythm1.32541239
48MP0004142_abnormal_muscle_tone1.31850448
49MP0002909_abnormal_adrenal_gland1.31566330
50MP0003633_abnormal_nervous_system1.31398922
51MP0006276_abnormal_autonomic_nervous1.30667299
52MP0001905_abnormal_dopamine_level1.30019394
53MP0005248_abnormal_Harderian_gland1.26656893
54MP0003631_nervous_system_phenotype1.20329256
55MP0002152_abnormal_brain_morphology1.17888492
56MP0004742_abnormal_vestibular_system1.17060387
57MP0003938_abnormal_ear_development1.16074161
58MP0001188_hyperpigmentation1.14902901
59MP0003136_yellow_coat_color1.14050759
60MP0004145_abnormal_muscle_electrophysio1.10939499
61MP0003878_abnormal_ear_physiology1.09858584
62MP0005377_hearing/vestibular/ear_phenot1.09858584
63MP0005645_abnormal_hypothalamus_physiol1.09168277
64MP0000569_abnormal_digit_pigmentation1.05931399
65MP0004133_heterotaxia1.04552638
66MP0006292_abnormal_olfactory_placode1.01772142
67MP0003632_abnormal_nervous_system1.00704103
68MP0003122_maternal_imprinting0.99944760
69MP0002638_abnormal_pupillary_reflex0.99603615
70MP0000920_abnormal_myelination0.99557571
71MP0002132_abnormal_respiratory_system0.99437302
72MP0002229_neurodegeneration0.97842754
73MP0005551_abnormal_eye_electrophysiolog0.96582702
74MP0002249_abnormal_larynx_morphology0.93613227
75MP0001346_abnormal_lacrimal_gland0.93151295
76MP0002069_abnormal_eating/drinking_beha0.90999639
77MP0003634_abnormal_glial_cell0.88743520
78MP0003690_abnormal_glial_cell0.88689007
79MP0002133_abnormal_respiratory_system0.88647715
80MP0005388_respiratory_system_phenotype0.88647715
81MP0000751_myopathy0.88592919
82MP0008789_abnormal_olfactory_epithelium0.88035098
83* MP0001963_abnormal_hearing_physiology0.87799292
84MP0005171_absent_coat_pigmentation0.86150054
85MP0001986_abnormal_taste_sensitivity0.85254837
86MP0003121_genomic_imprinting0.84772362
87MP0008874_decreased_physiological_sensi0.83364805
88MP0001485_abnormal_pinna_reflex0.83172851
89MP0008872_abnormal_physiological_respon0.82630072
90MP0001177_atelectasis0.81969332
91MP0002752_abnormal_somatic_nervous0.80792936
92MP0000604_amyloidosis0.80250889
93MP0004085_abnormal_heartbeat0.80210128
94MP0010386_abnormal_urinary_bladder0.78767047
95MP0004130_abnormal_muscle_cell0.78690430
96MP0003183_abnormal_peptide_metabolism0.77774363
97MP0000631_abnormal_neuroendocrine_gland0.75673798
98MP0003075_altered_response_to0.72699557
99MP0004484_altered_response_of0.71414790
100MP0002928_abnormal_bile_duct0.71316395
101MP0000013_abnormal_adipose_tissue0.71256577
102MP0005409_darkened_coat_color0.70117904
103MP0003828_pulmonary_edema0.69505153
104MP0004883_abnormal_blood_vessel0.68930691
105MP0005499_abnormal_olfactory_system0.68825431
106MP0005394_taste/olfaction_phenotype0.68825431
107MP0000465_gastrointestinal_hemorrhage0.68620802
108MP0002653_abnormal_ependyma_morphology0.67420402
109MP0004215_abnormal_myocardial_fiber0.66110910
110MP0002837_dystrophic_cardiac_calcinosis0.66080927
111MP0003137_abnormal_impulse_conducting0.65621362
112MP0003861_abnormal_nervous_system0.64318456
113MP0005535_abnormal_body_temperature0.63221090
114MP0002090_abnormal_vision0.62591648
115MP0004510_myositis0.62380077
116MP0003436_decreased_susceptibility_to0.61471475
117MP0009379_abnormal_foot_pigmentation0.59752782
118MP0000026_abnormal_inner_ear0.59195775
119MP0009278_abnormal_bone_marrow0.58714352
120MP0008961_abnormal_basal_metabolism0.58378802
121MP0010769_abnormal_survival0.56936773
122MP0001299_abnormal_eye_distance/0.56728254
123MP0010770_preweaning_lethality0.55558574
124MP0002082_postnatal_lethality0.55558574
125MP0001943_abnormal_respiration0.55133994
126MP0008877_abnormal_DNA_methylation0.54665660
127MP0001664_abnormal_digestion0.53996638
128MP0010768_mortality/aging0.53935788
129MP0003283_abnormal_digestive_organ0.52130425
130MP0002876_abnormal_thyroid_physiology0.51529447

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.58552195
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.60348497
3Myokymia (HP:0002411)6.48139314
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.31309099
5Absent/shortened dynein arms (HP:0200106)6.31309099
6Abnormal respiratory epithelium morphology (HP:0012253)6.21320157
7Abnormal respiratory motile cilium morphology (HP:0005938)6.21320157
8Abnormal ciliary motility (HP:0012262)6.13372507
9Focal seizures (HP:0007359)6.02237119
10Abnormal respiratory motile cilium physiology (HP:0012261)5.99434021
11Epileptic encephalopathy (HP:0200134)5.46446683
12Atonic seizures (HP:0010819)5.24905244
13Rhinitis (HP:0012384)5.23108885
14Visual hallucinations (HP:0002367)5.08391423
15Febrile seizures (HP:0002373)4.91145382
16Progressive cerebellar ataxia (HP:0002073)4.56685819
17Absence seizures (HP:0002121)4.41319130
18Dialeptic seizures (HP:0011146)4.17551804
19Broad-based gait (HP:0002136)4.13478511
20Hyperventilation (HP:0002883)4.06957581
21Generalized tonic-clonic seizures (HP:0002069)3.89853077
22Action tremor (HP:0002345)3.88657189
23Chronic bronchitis (HP:0004469)3.79313309
24Gaze-evoked nystagmus (HP:0000640)3.78505499
25Bronchiectasis (HP:0002110)3.73656921
26Nasal polyposis (HP:0100582)3.53576068
27Dysdiadochokinesis (HP:0002075)3.40234673
28Poor eye contact (HP:0000817)3.36758183
29Impaired vibration sensation in the lower limbs (HP:0002166)3.32938888
30Dysmetria (HP:0001310)3.30017928
31Supranuclear gaze palsy (HP:0000605)3.29154910
32Amblyopia (HP:0000646)3.18248010
33Excessive salivation (HP:0003781)3.10781164
34Drooling (HP:0002307)3.10781164
35Urinary bladder sphincter dysfunction (HP:0002839)3.04639461
36Truncal ataxia (HP:0002078)3.04443184
37Abnormality of the nasal mucosa (HP:0000433)3.01813166
38Abnormal social behavior (HP:0012433)3.00702365
39Impaired social interactions (HP:0000735)3.00702365
40Ankle clonus (HP:0011448)2.99527930
41Abnormal eating behavior (HP:0100738)2.95259038
42Scanning speech (HP:0002168)2.89789431
43Genetic anticipation (HP:0003743)2.87594632
44Depression (HP:0000716)2.87408159
45Abnormality of binocular vision (HP:0011514)2.77761819
46Diplopia (HP:0000651)2.77761819
47Postural instability (HP:0002172)2.76007107
48Hemiparesis (HP:0001269)2.74468313
49Anxiety (HP:0000739)2.73476041
50Impaired smooth pursuit (HP:0007772)2.72787199
51Mutism (HP:0002300)2.72453449
52Abnormality of the lower motor neuron (HP:0002366)2.70541270
53Absent speech (HP:0001344)2.69741058
54Cerebral inclusion bodies (HP:0100314)2.68041261
55Spastic gait (HP:0002064)2.66846738
56Neurofibrillary tangles (HP:0002185)2.66747251
57Sleep apnea (HP:0010535)2.66226635
58Progressive inability to walk (HP:0002505)2.62600161
59Abnormality of the corticospinal tract (HP:0002492)2.61132880
60Intention tremor (HP:0002080)2.59861272
61Epileptiform EEG discharges (HP:0011182)2.59080721
62Urinary urgency (HP:0000012)2.54132509
63Recurrent sinusitis (HP:0011108)2.51077676
64Chronic otitis media (HP:0000389)2.50727668
65Stereotypic behavior (HP:0000733)2.49758572
66Termporal pattern (HP:0011008)2.47732154
67Insidious onset (HP:0003587)2.47732154
68True hermaphroditism (HP:0010459)2.43436961
69Abnormality of ocular smooth pursuit (HP:0000617)2.40395461
70EEG with generalized epileptiform discharges (HP:0011198)2.40239059
71Pancreatic fibrosis (HP:0100732)2.38915936
72Dysmetric saccades (HP:0000641)2.38834067
73Hemiplegia (HP:0002301)2.37293024
74Impaired vibratory sensation (HP:0002495)2.33927302
75Hypochromic microcytic anemia (HP:0004840)2.31627530
76Recurrent bacterial skin infections (HP:0005406)2.30836603
77Bradykinesia (HP:0002067)2.30760006
78Papilledema (HP:0001085)2.27874369
79Inability to walk (HP:0002540)2.27791711
80Fetal akinesia sequence (HP:0001989)2.26598915
81Torticollis (HP:0000473)2.25976652
82Megalencephaly (HP:0001355)2.25775121
83Generalized myoclonic seizures (HP:0002123)2.25274454
84Protruding tongue (HP:0010808)2.25138139
85Hypsarrhythmia (HP:0002521)2.24438709
86Recurrent abscess formation (HP:0002722)2.23147921
87Blue irides (HP:0000635)2.20378746
88Eczematoid dermatitis (HP:0000976)2.19762301
89Focal dystonia (HP:0004373)2.18744404
90Status epilepticus (HP:0002133)2.17106695
91Chronic sinusitis (HP:0011109)2.12979540
92Lower limb muscle weakness (HP:0007340)2.12398685
93Recurrent otitis media (HP:0000403)2.11636106
94Infertility (HP:0000789)2.11143068
95Recurrent gram-negative bacterial infections (HP:0005420)2.11017955
96Polyphagia (HP:0002591)2.10325267
97Degeneration of the lateral corticospinal tracts (HP:0002314)2.07642383
98Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.07642383
99Abnormality of salivation (HP:0100755)2.05916772
100Gait ataxia (HP:0002066)2.04718581
101Septo-optic dysplasia (HP:0100842)2.02115002
102Incomplete penetrance (HP:0003829)2.00563033
103Annular pancreas (HP:0001734)2.00094581
104Myositis (HP:0100614)1.96626747
105Occipital encephalocele (HP:0002085)1.95992230
106Tetraplegia (HP:0002445)1.95153974
107Bronchitis (HP:0012387)1.92591651
108Ventricular fibrillation (HP:0001663)1.92209426
109Cystic liver disease (HP:0006706)1.91346760
110Inappropriate behavior (HP:0000719)1.90286771
111Retrobulbar optic neuritis (HP:0100654)1.88845161
112Optic neuritis (HP:0100653)1.88845161
113Amyotrophic lateral sclerosis (HP:0007354)1.87806046
114Nephronophthisis (HP:0000090)1.86204636
115Neuronal loss in central nervous system (HP:0002529)1.85979740
116Split foot (HP:0001839)1.85816813
117Craniofacial dystonia (HP:0012179)1.85669741
118Orchitis (HP:0100796)1.84472779
119Lower limb asymmetry (HP:0100559)1.81495350
120Abnormality of saccadic eye movements (HP:0000570)1.79938859
121Specific learning disability (HP:0001328)1.79450486
122Widely spaced teeth (HP:0000687)1.79417126
123Obstructive sleep apnea (HP:0002870)1.79271904
124Pointed chin (HP:0000307)1.79143613
125Gait imbalance (HP:0002141)1.78226972
126Delusions (HP:0000746)1.78097587
127Spontaneous hematomas (HP:0007420)1.77942229
128Abnormality of midbrain morphology (HP:0002418)1.75976561
129Molar tooth sign on MRI (HP:0002419)1.75976561
130Pancreatic cysts (HP:0001737)1.73782846
131Psychosis (HP:0000709)1.72493982
132Thickened helices (HP:0000391)1.71644958
133Clumsiness (HP:0002312)1.71597430
134Aqueductal stenosis (HP:0002410)1.70809510
135Agitation (HP:0000713)1.68861282
136Limb dystonia (HP:0002451)1.67632382
137Clonus (HP:0002169)1.67356693
138Anencephaly (HP:0002323)1.67149980
139Pheochromocytoma (HP:0002666)1.65247459
140Autism (HP:0000717)1.64293660
141Lower limb amyotrophy (HP:0007210)1.63782529
142Memory impairment (HP:0002354)1.61762030
143Atelectasis (HP:0100750)1.60480233
144Apathy (HP:0000741)1.59265322
145Peripheral hypomyelination (HP:0007182)1.56883781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.58237474
2NTRK34.39917727
3MAP3K93.44531955
4MAP3K43.10650066
5CASK2.99693455
6MARK12.89813527
7DAPK22.70137740
8MAP2K72.62363226
9MINK12.46412956
10MAPK152.44953289
11PAK62.25052757
12NTRK22.18840189
13MAP3K111.91486149
14RIPK41.90476477
15CDK191.86838379
16KSR21.84610273
17PLK21.83989458
18MAP3K121.80282186
19MAP2K41.79320884
20PRKD31.73947395
21KSR11.72386676
22TNIK1.68766393
23CAMKK11.68321172
24DAPK11.65580828
25PRPF4B1.57683348
26PNCK1.53249168
27CDK51.53119542
28NTRK11.48382451
29TYRO31.46808934
30MAPK131.41046083
31FES1.32364752
32MAP3K131.31697985
33SIK21.31315274
34OXSR11.27249175
35GRK51.26270929
36CSK1.24283112
37PRKCG1.17897419
38CAMKK21.17459148
39ARAF1.17385866
40STK381.10670327
41CAMK2A1.07613849
42IRAK41.01716573
43PTK2B1.01647175
44SGK2231.01437885
45SGK4941.01437885
46BLK1.00207387
47UHMK10.99609027
48BMPR20.94732151
49CAMK10.93642168
50CAMK2B0.92110462
51MAP2K30.91535239
52STK110.91001522
53CDK180.87936345
54YES10.86210556
55EPHB10.85417727
56SGK20.85227508
57CDK150.84238254
58CDK140.80373491
59MAP3K20.79383079
60CCNB10.78767291
61LATS20.77621615
62RAF10.77459567
63SGK10.77235154
64TAOK10.77027971
65TIE10.74852640
66CAMK1G0.74622998
67MAPK120.73583015
68FGR0.72677908
69CDK11A0.72182369
70SIK30.70752544
71MARK20.70060031
72IRAK20.69367752
73JAK20.69363912
74RET0.69287004
75DYRK1A0.68589881
76PHKG10.67835898
77PHKG20.67835898
78PAK30.64959304
79PRKCH0.63832820
80SGK30.63556796
81ERBB20.60533612
82CSNK1G20.60028580
83DYRK20.58156176
84BCR0.57528190
85PDK10.57277935
86NME10.57129782
87RIPK10.56686618
88PDPK10.56673472
89PINK10.56520032
90AKT30.55868776
91PRKCE0.54724906
92EPHB20.52249513
93HCK0.51953675
94NEK60.51333602
95PRKD20.51282346
96GRK60.50549317
97LRRK20.49537265
98RPS6KA30.48641193
99STK390.47407429
100MAP3K60.47315719
101CAMK2D0.47022672
102CAMK2G0.45898957
103FYN0.45704183
104CAMK40.45670889
105EPHA30.45394304
106WNK10.44969441
107PRKCZ0.44867482
108ALK0.44513853
109DYRK1B0.43418466
110ROCK20.42847744
111MAPK100.40937552
112CDC42BPA0.40927994
113PKN10.40295361
114CAMK1D0.39788067
115FGFR20.39708457
116WNK30.39672879
117BRAF0.39400452
118FER0.39319997
119PTK60.37724236
120MAP3K10.37519171
121MAPK70.36363759
122MAP3K70.35809933
123TNK20.35108708
124DAPK30.34830139
125MAP3K50.34320926
126DMPK0.33881140
127MUSK0.30686606

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03011689
2Synaptic vesicle cycle_Homo sapiens_hsa047213.25401748
3Long-term potentiation_Homo sapiens_hsa047202.85962938
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.84882541
5Circadian entrainment_Homo sapiens_hsa047132.78741930
6Glutamatergic synapse_Homo sapiens_hsa047242.77996786
7GABAergic synapse_Homo sapiens_hsa047272.70826959
8Olfactory transduction_Homo sapiens_hsa047402.63595635
9Morphine addiction_Homo sapiens_hsa050322.54529368
10Amphetamine addiction_Homo sapiens_hsa050312.50477130
11Salivary secretion_Homo sapiens_hsa049702.22390852
12Dopaminergic synapse_Homo sapiens_hsa047282.15908390
13Insulin secretion_Homo sapiens_hsa049111.94050134
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92964446
15Gastric acid secretion_Homo sapiens_hsa049711.89396028
16Long-term depression_Homo sapiens_hsa047301.87456726
17Cholinergic synapse_Homo sapiens_hsa047251.87366581
18Taste transduction_Homo sapiens_hsa047421.81334304
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80776593
20Serotonergic synapse_Homo sapiens_hsa047261.70719614
21Renin secretion_Homo sapiens_hsa049241.70456804
22Collecting duct acid secretion_Homo sapiens_hsa049661.68889822
23Oxytocin signaling pathway_Homo sapiens_hsa049211.67602451
24Calcium signaling pathway_Homo sapiens_hsa040201.62964863
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60818876
26Cocaine addiction_Homo sapiens_hsa050301.48760424
27GnRH signaling pathway_Homo sapiens_hsa049121.45561701
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34980510
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30331387
30cAMP signaling pathway_Homo sapiens_hsa040241.29813900
31Gap junction_Homo sapiens_hsa045401.26599863
32* Axon guidance_Homo sapiens_hsa043601.23628514
33Notch signaling pathway_Homo sapiens_hsa043301.23463584
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20984728
35Glioma_Homo sapiens_hsa052141.15944166
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15618540
37Type II diabetes mellitus_Homo sapiens_hsa049301.14967524
38Osteoclast differentiation_Homo sapiens_hsa043801.12733080
39Estrogen signaling pathway_Homo sapiens_hsa049151.12642244
40ErbB signaling pathway_Homo sapiens_hsa040121.10078248
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08410811
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07496716
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07302006
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05779398
45Melanogenesis_Homo sapiens_hsa049161.05324079
46Phototransduction_Homo sapiens_hsa047441.01311300
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00491031
48Vibrio cholerae infection_Homo sapiens_hsa051101.00402209
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.93973406
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93075576
51Cardiac muscle contraction_Homo sapiens_hsa042600.92045045
52Oocyte meiosis_Homo sapiens_hsa041140.89062053
53Dorso-ventral axis formation_Homo sapiens_hsa043200.88802127
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86555304
55Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86234171
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.84362604
57Pancreatic secretion_Homo sapiens_hsa049720.84254418
58Tuberculosis_Homo sapiens_hsa051520.80664185
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75814219
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75596281
61Choline metabolism in cancer_Homo sapiens_hsa052310.75429290
62B cell receptor signaling pathway_Homo sapiens_hsa046620.72706295
63MAPK signaling pathway_Homo sapiens_hsa040100.71332033
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70665755
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.70485130
66Thyroid hormone synthesis_Homo sapiens_hsa049180.68989848
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68797317
68Leishmaniasis_Homo sapiens_hsa051400.66863651
69Histidine metabolism_Homo sapiens_hsa003400.66381595
70Dilated cardiomyopathy_Homo sapiens_hsa054140.66019831
71Nitrogen metabolism_Homo sapiens_hsa009100.64559720
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.64419306
73Ras signaling pathway_Homo sapiens_hsa040140.62117398
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61599008
75VEGF signaling pathway_Homo sapiens_hsa043700.57689743
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56772278
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.56364130
78Phagosome_Homo sapiens_hsa041450.55982995
79Circadian rhythm_Homo sapiens_hsa047100.55912355
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.55819035
81Hedgehog signaling pathway_Homo sapiens_hsa043400.55352356
82Rap1 signaling pathway_Homo sapiens_hsa040150.54284237
83Inositol phosphate metabolism_Homo sapiens_hsa005620.52226592
84* Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51940075
85Glucagon signaling pathway_Homo sapiens_hsa049220.51191907
86Renal cell carcinoma_Homo sapiens_hsa052110.50101460
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49738018
88Amoebiasis_Homo sapiens_hsa051460.48448479
89Wnt signaling pathway_Homo sapiens_hsa043100.47368544
90Alzheimers disease_Homo sapiens_hsa050100.47098291
91Prolactin signaling pathway_Homo sapiens_hsa049170.46795829
92Colorectal cancer_Homo sapiens_hsa052100.46033576
93Type I diabetes mellitus_Homo sapiens_hsa049400.45924782
94Platelet activation_Homo sapiens_hsa046110.44708296
95Alcoholism_Homo sapiens_hsa050340.43829492
96FoxO signaling pathway_Homo sapiens_hsa040680.43718057
97Malaria_Homo sapiens_hsa051440.43613050
98Endocytosis_Homo sapiens_hsa041440.43021104
99beta-Alanine metabolism_Homo sapiens_hsa004100.42462583
100mTOR signaling pathway_Homo sapiens_hsa041500.41723916
101Staphylococcus aureus infection_Homo sapiens_hsa051500.41285812
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41085251
103African trypanosomiasis_Homo sapiens_hsa051430.40571849
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39991957
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39461955
106Non-small cell lung cancer_Homo sapiens_hsa052230.39228612
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38543948
108Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37223571
109Prion diseases_Homo sapiens_hsa050200.36543935
110Endometrial cancer_Homo sapiens_hsa052130.36411360
111Ovarian steroidogenesis_Homo sapiens_hsa049130.35641328
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35041556
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34491631
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33558211
115Bile secretion_Homo sapiens_hsa049760.32174784
116Chemokine signaling pathway_Homo sapiens_hsa040620.31984323
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31312522
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29588484
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26673638
120Rheumatoid arthritis_Homo sapiens_hsa053230.26637304
121Oxidative phosphorylation_Homo sapiens_hsa001900.25147995
122Insulin signaling pathway_Homo sapiens_hsa049100.24754413

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