LRRC39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.38953662
2cardiac myofibril assembly (GO:0055003)8.35468571
3actin-myosin filament sliding (GO:0033275)7.94626471
4muscle filament sliding (GO:0030049)7.94626471
5myofibril assembly (GO:0030239)7.86787363
6regulation of relaxation of muscle (GO:1901077)6.94286691
7negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.89588716
8creatine metabolic process (GO:0006600)6.82642764
9actin-mediated cell contraction (GO:0070252)6.71846528
10regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.69950184
11tricarboxylic acid cycle (GO:0006099)6.69720631
12cardiac muscle contraction (GO:0060048)6.57613870
13regulation of skeletal muscle contraction (GO:0014819)6.57609856
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.49723844
15response to muscle activity (GO:0014850)6.48678614
16heart process (GO:0003015)6.28483222
17heart contraction (GO:0060047)6.28483222
18regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.23619596
19regulation of sarcomere organization (GO:0060297)6.19875387
20cardiac muscle cell development (GO:0055013)6.08016576
21negative regulation of potassium ion transmembrane transport (GO:1901380)6.01472076
22regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.87309728
23regulation of actin filament-based movement (GO:1903115)5.82296500
24sarcoplasmic reticulum calcium ion transport (GO:0070296)5.80352253
25cardiac muscle hypertrophy (GO:0003300)5.76789805
26cardiac cell development (GO:0055006)5.74048499
27cardiac muscle tissue morphogenesis (GO:0055008)5.73963930
28skeletal muscle fiber development (GO:0048741)5.65568506
29regulation of cell communication by electrical coupling (GO:0010649)5.62916495
30striated muscle contraction (GO:0006941)5.58898414
31actomyosin structure organization (GO:0031032)5.53274049
32regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.48536186
33striated muscle hypertrophy (GO:0014897)5.47313420
34carnitine shuttle (GO:0006853)5.36622467
35regulation of acyl-CoA biosynthetic process (GO:0050812)5.29847460
36myotube cell development (GO:0014904)5.23577798
37ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.19499950
38muscle tissue morphogenesis (GO:0060415)5.15522744
39adult heart development (GO:0007512)5.10863827
40glycogen catabolic process (GO:0005980)5.01831778
41response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.95636180
42muscle hypertrophy (GO:0014896)4.95298555
43regulation of striated muscle contraction (GO:0006942)4.93389063
44bundle of His cell to Purkinje myocyte communication (GO:0086069)4.92986082
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.87876683
46ventricular cardiac muscle cell action potential (GO:0086005)4.86941949
47actin filament-based movement (GO:0030048)4.83059155
48regulation of coenzyme metabolic process (GO:0051196)4.80360948
49regulation of cofactor metabolic process (GO:0051193)4.80360948
50oxidative phosphorylation (GO:0006119)4.78763441
51muscle fiber development (GO:0048747)4.76097145
52plasma membrane repair (GO:0001778)4.75217249
53fatty acid transmembrane transport (GO:1902001)4.71674213
54glucan catabolic process (GO:0009251)4.70588284
55regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.68902235
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.68514323
57heart trabecula formation (GO:0060347)4.61763980
58regulation of sequestering of triglyceride (GO:0010889)4.60140444
59glycogen biosynthetic process (GO:0005978)4.58664456
60glucan biosynthetic process (GO:0009250)4.58664456
61respiratory electron transport chain (GO:0022904)4.58508137
62skeletal muscle tissue development (GO:0007519)4.55368675
63electron transport chain (GO:0022900)4.44090629
64mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.43248287
65cellular polysaccharide catabolic process (GO:0044247)4.41804547
66skeletal muscle contraction (GO:0003009)4.38736471
67energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26507427
68ATP synthesis coupled proton transport (GO:0015986)4.26507427
69regulation of the force of heart contraction (GO:0002026)4.22234774
70skeletal muscle tissue regeneration (GO:0043403)4.19344222
71muscle cell cellular homeostasis (GO:0046716)4.17000815
72regulation of membrane repolarization (GO:0060306)4.14035590
73cardiac muscle adaptation (GO:0014887)4.06045962
74cardiac muscle hypertrophy in response to stress (GO:0014898)4.06045962
75muscle hypertrophy in response to stress (GO:0003299)4.06045962
76polysaccharide catabolic process (GO:0000272)3.97434511
77regulation of calcium ion transmembrane transporter activity (GO:1901019)3.96705936
78regulation of calcium ion transmembrane transport (GO:1903169)3.96705936
79regulation of cardiac muscle contraction (GO:0055117)3.94396941
80regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.92989698
81negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.91360363
82negative regulation of calcium ion transmembrane transport (GO:1903170)3.91360363
83carnitine transmembrane transport (GO:1902603)3.88989325
84NADH metabolic process (GO:0006734)3.84537126
85regulation of sulfur metabolic process (GO:0042762)3.82826525
86relaxation of cardiac muscle (GO:0055119)3.81334782
87striated muscle atrophy (GO:0014891)3.80464407
88muscle structure development (GO:0061061)3.78546430
89cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.77196127
90negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.77112330
91muscle organ development (GO:0007517)3.76020922
92muscle cell fate commitment (GO:0042693)3.71115732
93pyrimidine ribonucleoside catabolic process (GO:0046133)3.70915864
94positive regulation of myotube differentiation (GO:0010831)3.70238156
95regulation of cardiac muscle cell contraction (GO:0086004)3.70115164
96glycogen metabolic process (GO:0005977)3.67407303
97negative regulation of protein localization to cell surface (GO:2000009)3.66504094
98cardiac muscle cell action potential involved in contraction (GO:0086002)3.65215465
99cardiac muscle cell action potential (GO:0086001)3.65125532
100muscle contraction (GO:0006936)3.64570867
101striated muscle cell development (GO:0055002)3.63218669
102regulation of heart rate (GO:0002027)3.62218137
103striated muscle adaptation (GO:0014888)3.62081907
104cell communication involved in cardiac conduction (GO:0086065)3.61483551
105cellular glucan metabolic process (GO:0006073)3.59753938
106glucan metabolic process (GO:0044042)3.59753938
107muscle adaptation (GO:0043500)3.58993381
108response to inactivity (GO:0014854)3.56595311
109negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.55657174
110ubiquinone biosynthetic process (GO:0006744)3.55529914
111quinone biosynthetic process (GO:1901663)3.55529914
112negative regulation of striated muscle cell apoptotic process (GO:0010664)3.50985343
113muscle system process (GO:0003012)3.47393560
114gluconeogenesis (GO:0006094)3.46742853
115amino-acid betaine transport (GO:0015838)3.45608084
116carnitine transport (GO:0015879)3.45608084
117cytidine metabolic process (GO:0046087)3.45401247
118cytidine catabolic process (GO:0006216)3.45401247
119cytidine deamination (GO:0009972)3.45401247
120muscle atrophy (GO:0014889)3.44037810
121relaxation of muscle (GO:0090075)3.43865335
122response to activity (GO:0014823)3.41817273
123regulation of ATP catabolic process (GO:1903289)3.41183472
124regulation of ATPase activity (GO:0043462)3.41183472
125positive regulation of cation channel activity (GO:2001259)3.40675320
126skeletal muscle adaptation (GO:0043501)3.40614039
127regulation of muscle contraction (GO:0006937)3.40264921
1282-oxoglutarate metabolic process (GO:0006103)3.39443746
129muscle cell development (GO:0055001)3.38799680
130regulation of myoblast differentiation (GO:0045661)3.36518745
131fructose metabolic process (GO:0006000)3.36495370
132regulation of muscle system process (GO:0090257)3.34717159
133regulation of skeletal muscle cell differentiation (GO:2001014)3.34283494
134cardiac chamber formation (GO:0003207)3.33840246
135cardiac conduction (GO:0061337)3.32584362
136positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.32466816
137fatty acid beta-oxidation (GO:0006635)3.32044687
138striated muscle tissue development (GO:0014706)3.29053193
139regulation of heart contraction (GO:0008016)3.28082419
140positive regulation of myoblast differentiation (GO:0045663)3.26626334
141succinate metabolic process (GO:0006105)3.26345272
142muscle organ morphogenesis (GO:0048644)3.25412562

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.56562277
2EP300_21415370_ChIP-Seq_HL-1_Mouse5.47984067
3EZH2_22144423_ChIP-Seq_EOC_Human5.29990620
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.41624260
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.35197352
6ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.96646815
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.92318096
8TBX20_22080862_ChIP-Seq_HEART_Mouse3.75700796
9TBX20_22328084_ChIP-Seq_HEART_Mouse3.75700796
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.62959257
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.42918746
12* GATA4_21415370_ChIP-Seq_HL-1_Mouse3.11438388
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.07559624
14GATA1_22025678_ChIP-Seq_K562_Human2.42443014
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.40677233
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.36382470
17NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.17258281
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.10006601
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.97822507
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.86965740
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70380723
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.69193082
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62895741
24IGF1R_20145208_ChIP-Seq_DFB_Human1.62117701
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58320522
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55299182
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.54061622
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.52512914
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.50584866
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49531238
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47869068
32BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47166122
33EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46931036
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43874479
35AR_21572438_ChIP-Seq_LNCaP_Human1.38153136
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.34971272
37NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31138986
38ZNF263_19887448_ChIP-Seq_K562_Human1.21395939
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21115195
40CJUN_26792858_Chip-Seq_BT549_Human1.18835373
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17261617
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17045603
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.15213756
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.14573864
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.14398022
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14272089
47DROSHA_22980978_ChIP-Seq_HELA_Human1.13804876
48ISL1_27105846_Chip-Seq_CPCs_Mouse1.13736336
49OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12903839
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.08981358
51CTCF_27219007_Chip-Seq_Bcells_Human1.08830861
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.08084244
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.06418404
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05882497
55ER_23166858_ChIP-Seq_MCF-7_Human1.05718133
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05634625
57VDR_22108803_ChIP-Seq_LS180_Human1.05388692
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04354582
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.02243853
60BCAT_22108803_ChIP-Seq_LS180_Human1.02175569
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02024042
62TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01010037
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99702630
64* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98922531
65STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98631450
66* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98421197
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95724334
68HTT_18923047_ChIP-ChIP_STHdh_Human0.95373569
69BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95100968
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94986984
71SMAD_19615063_ChIP-ChIP_OVARY_Human0.94145115
72CIITA_25753668_ChIP-Seq_RAJI_Human0.93399044
73ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92891963
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92093844
75AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92085366
76GBX2_23144817_ChIP-Seq_PC3_Human0.89810027
77KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89662362
78SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89549824
79YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88769831
80P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88289576
81* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88096976
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88017113
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88017113
84ESR2_21235772_ChIP-Seq_MCF-7_Human0.87646783
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87624344
86KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.87397453
87MYC_27129775_Chip-Seq_CORNEA_Mouse0.87374977
88PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87313085
89* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.85453369
90SMAD4_21799915_ChIP-Seq_A2780_Human0.85392015
91MYC_19829295_ChIP-Seq_ESCs_Human0.84700229
92EZH2_27304074_Chip-Seq_ESCs_Mouse0.84172907
93TRIM28_21343339_ChIP-Seq_HEK293_Human0.83971023
94SOX2_19829295_ChIP-Seq_ESCs_Human0.82910783
95NANOG_19829295_ChIP-Seq_ESCs_Human0.82910783
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82010340
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.81708294
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81505447
99FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81099739
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80363155
101SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.79130423
102TBX5_21415370_ChIP-Seq_HL-1_Mouse0.78941419
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78326052
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78050558
105STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.77986281
106* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77967783
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.77868337
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.77536306
109OCT4_20526341_ChIP-Seq_ESCs_Human0.77383869
110CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77217563
111* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.77109357
112LXR_22158963_ChIP-Seq_LIVER_Mouse0.77052876
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.76675202
114E2F1_18555785_Chip-Seq_ESCs_Mouse0.76549234
115TOP2B_26459242_ChIP-Seq_MCF-7_Human0.76487830
116NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75951706
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75940893
118STAT3_18555785_Chip-Seq_ESCs_Mouse0.75878146
119MTF2_20144788_ChIP-Seq_MESCs_Mouse0.75818849
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75797506
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.74972491
122CBP_20019798_ChIP-Seq_JUKART_Human0.74862102
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74862102
124* GATA6_21074721_ChIP-Seq_CACO-2_Human0.74747799
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74742788
126PPARA_22158963_ChIP-Seq_LIVER_Mouse0.74518968
127EGR1_19032775_ChIP-ChIP_M12_Human0.73850618
128GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73712027
129SPI1_20517297_ChIP-Seq_HL60_Human0.73461018
130CBP_21632823_ChIP-Seq_H3396_Human0.73415724
131* PHF8_20622853_ChIP-Seq_HELA_Human0.73312198
132ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.71342570
133* NFYB_21822215_ChIP-Seq_K562_Human0.70964040
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70962489
135VDR_24787735_ChIP-Seq_THP-1_Human0.70935806
136P53_22387025_ChIP-Seq_ESCs_Mouse0.70363576
137* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70187456
138PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.70025433
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.69248763
140SOX2_18555785_Chip-Seq_ESCs_Mouse0.69175823
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.69119520
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.68763656
143AR_20517297_ChIP-Seq_VCAP_Human0.68491023
144NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.68091089
145GF1_26923725_Chip-Seq_HPCs_Mouse0.67641833
146NFI_21473784_ChIP-Seq_ESCs_Mouse0.67555451
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.66499816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.81854992
2MP0002837_dystrophic_cardiac_calcinosis5.81483830
3MP0004084_abnormal_cardiac_muscle5.46495371
4MP0000751_myopathy4.70400122
5MP0004215_abnormal_myocardial_fiber4.67283924
6MP0000749_muscle_degeneration4.64305008
7MP0004036_abnormal_muscle_relaxation4.30285113
8MP0005330_cardiomyopathy3.86258003
9MP0002972_abnormal_cardiac_muscle3.27761450
10MP0004087_abnormal_muscle_fiber3.08063847
11MP0005620_abnormal_muscle_contractility2.95863658
12MP0004130_abnormal_muscle_cell2.94371947
13MP0008775_abnormal_heart_ventricle2.89990761
14MP0004145_abnormal_muscle_electrophysio2.87962750
15MP0003137_abnormal_impulse_conducting2.74418172
16MP0004484_altered_response_of2.73640941
17MP0002106_abnormal_muscle_physiology2.71569675
18MP0001544_abnormal_cardiovascular_syste2.64228345
19MP0005385_cardiovascular_system_phenoty2.64228345
20MP0003828_pulmonary_edema2.56220076
21MP0010630_abnormal_cardiac_muscle2.55385180
22MP0000750_abnormal_muscle_regeneration2.39686393
23MP0006138_congestive_heart_failure2.34152108
24MP0005670_abnormal_white_adipose2.29918487
25MP0002269_muscular_atrophy2.26143843
26MP0006036_abnormal_mitochondrial_physio2.22908523
27MP0005369_muscle_phenotype2.21667593
28MP0003221_abnormal_cardiomyocyte_apopto2.11121622
29MP0000759_abnormal_skeletal_muscle2.07891722
30MP0002127_abnormal_cardiovascular_syste2.06258445
31MP0004510_myositis1.97230758
32MP0004085_abnormal_heartbeat1.95734099
33MP0003950_abnormal_plasma_membrane1.87234136
34MP0000747_muscle_weakness1.85166591
35MP0005666_abnormal_adipose_tissue1.59453732
36MP0002332_abnormal_exercise_endurance1.52457689
37MP0004270_analgesia1.45145800
38MP0003567_abnormal_fetal_cardiomyocyte1.43667668
39MP0004233_abnormal_muscle_weight1.39012673
40MP0000343_altered_response_to1.35518415
41MP0006035_abnormal_mitochondrial_morpho1.22335577
42MP0004147_increased_porphyrin_level1.19926734
43MP0000266_abnormal_heart_morphology1.11652463
44MP0005165_increased_susceptibility_to1.09487737
45MP0001661_extended_life_span1.06162795
46MP0010368_abnormal_lymphatic_system1.03381831
47MP0005451_abnormal_body_composition0.98640952
48MP0005375_adipose_tissue_phenotype0.98239064
49MP0004185_abnormal_adipocyte_glucose0.97815462
50MP0002822_catalepsy0.97198634
51MP0002108_abnormal_muscle_morphology0.91104911
52MP0003279_aneurysm0.86209180
53MP0001879_abnormal_lymphatic_vessel0.85430336
54MP0005266_abnormal_metabolism0.81747006
55MP0000372_irregular_coat_pigmentation0.79992438
56MP0002971_abnormal_brown_adipose0.78101230
57MP0000230_abnormal_systemic_arterial0.77594526
58MP0002234_abnormal_pharynx_morphology0.74792704
59MP0002128_abnormal_blood_circulation0.71531500
60MP0009780_abnormal_chondrocyte_physiolo0.69484486
61MP0003045_fibrosis0.64379713
62MP0000767_abnormal_smooth_muscle0.59383709
63MP0000733_abnormal_muscle_development0.58427634
64MP0004142_abnormal_muscle_tone0.55114726
65MP0004134_abnormal_chest_morphology0.54751930
66MP0000013_abnormal_adipose_tissue0.52983718
67MP0003566_abnormal_cell_adhesion0.52789989
68MP0003186_abnormal_redox_activity0.51896108
69MP0008569_lethality_at_weaning0.51633866
70MP0000003_abnormal_adipose_tissue0.51000056
71MP0001299_abnormal_eye_distance/0.50188304
72MP0002078_abnormal_glucose_homeostasis0.49569151
73MP0005334_abnormal_fat_pad0.49058090
74MP0003879_abnormal_hair_cell0.47974024
75MP0005171_absent_coat_pigmentation0.47605314
76MP0005319_abnormal_enzyme/_coenzyme0.45025960
77MP0009697_abnormal_copulation0.44801459
78MP0009115_abnormal_fat_cell0.43020081
79MP0003941_abnormal_skin_development0.42936167
80MP0004043_abnormal_pH_regulation0.41406145
81MP0005535_abnormal_body_temperature0.38919042
82MP0002925_abnormal_cardiovascular_devel0.36842473
83MP0003984_embryonic_growth_retardation0.34598654
84MP0003948_abnormal_gas_homeostasis0.34571570
85MP0002088_abnormal_embryonic_growth/wei0.33519198
86MP0001784_abnormal_fluid_regulation0.33321106
87MP0009672_abnormal_birth_weight0.33284548
88MP0005167_abnormal_blood-brain_barrier0.33247517
89MP0005187_abnormal_penis_morphology0.32986547
90MP0002734_abnormal_mechanical_nocicepti0.31860771
91MP0001984_abnormal_olfaction0.31792169
92MP0001614_abnormal_blood_vessel0.31200925
93MP0001853_heart_inflammation0.30620123
94MP0005332_abnormal_amino_acid0.30397966
95MP0002638_abnormal_pupillary_reflex0.29036624
96MP0003136_yellow_coat_color0.28296739
97MP0004272_abnormal_basement_membrane0.27966827
98MP0002114_abnormal_axial_skeleton0.27622979
99MP0000762_abnormal_tongue_morphology0.27014417
100MP0009250_abnormal_appendicular_skeleto0.26805160
101MP0005377_hearing/vestibular/ear_phenot0.26482662
102MP0003878_abnormal_ear_physiology0.26482662
103MP0005595_abnormal_vascular_smooth0.25476876
104MP0002133_abnormal_respiratory_system0.25267799
105MP0005388_respiratory_system_phenotype0.25267799
106MP0005166_decreased_susceptibility_to0.25130661
107MP0005452_abnormal_adipose_tissue0.25077302
108MP0002877_abnormal_melanocyte_morpholog0.24920217
109MP0000516_abnormal_urinary_system0.23821095
110MP0005367_renal/urinary_system_phenotyp0.23821095
111MP0001943_abnormal_respiration0.23469829
112MP0008438_abnormal_cutaneous_collagen0.23446245
113MP0002066_abnormal_motor_capabilities/c0.23390151
114MP0003195_calcinosis0.23182978
115MP0005376_homeostasis/metabolism_phenot0.22246821
116MP0005083_abnormal_biliary_tract0.21709200
117MP0005386_behavior/neurological_phenoty0.21563038
118MP0004924_abnormal_behavior0.21563038
119MP0006276_abnormal_autonomic_nervous0.21447925
120MP0005584_abnormal_enzyme/coenzyme_acti0.21419500
121MP0010030_abnormal_orbit_morphology0.20722512
122MP0001346_abnormal_lacrimal_gland0.20278018
123MP0003806_abnormal_nucleotide_metabolis0.19815253
124MP0005423_abnormal_somatic_nervous0.19170892
125MP0004782_abnormal_surfactant_physiolog0.19050031
126MP0002896_abnormal_bone_mineralization0.18814774
127MP0000249_abnormal_blood_vessel0.18811177
128MP0003656_abnormal_erythrocyte_physiolo0.18726671
129MP0002970_abnormal_white_adipose0.17235434
130MP0009384_cardiac_valve_regurgitation0.16700966
131MP0002876_abnormal_thyroid_physiology0.14333479

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.08071563
2Calf muscle hypertrophy (HP:0008981)6.80060341
3Ventricular tachycardia (HP:0004756)6.41512492
4Muscle hypertrophy of the lower extremities (HP:0008968)6.38943667
5Exercise-induced muscle cramps (HP:0003710)6.36008203
6Distal arthrogryposis (HP:0005684)6.24982250
7Exercise-induced myalgia (HP:0003738)6.17570580
8Atrial fibrillation (HP:0005110)5.76541873
9Myopathic facies (HP:0002058)5.34299438
10Primary atrial arrhythmia (HP:0001692)5.32994523
11Myoglobinuria (HP:0002913)5.23908991
12Subaortic stenosis (HP:0001682)5.22722134
13Abnormality of the left ventricular outflow tract (HP:0011103)5.22722134
14Lipoatrophy (HP:0100578)5.22030485
15Supraventricular tachycardia (HP:0004755)5.17277633
16Abnormality of the calf musculature (HP:0001430)5.11146540
17Round ear (HP:0100830)5.05220924
18Supraventricular arrhythmia (HP:0005115)5.04145486
19Muscle fiber splitting (HP:0003555)4.79789238
20Ulnar deviation of the wrist (HP:0003049)4.70109969
21Dilated cardiomyopathy (HP:0001644)4.48354666
22Syncope (HP:0001279)4.38051642
23Hyporeflexia of lower limbs (HP:0002600)4.21193213
24Right ventricular cardiomyopathy (HP:0011663)4.20196388
25Palpitations (HP:0001962)4.16952866
26Calcaneovalgus deformity (HP:0001848)4.10670325
27Rhabdomyolysis (HP:0003201)4.08108374
28EMG: myopathic abnormalities (HP:0003458)4.04405561
29Prolonged QT interval (HP:0001657)3.95305681
30Bundle branch block (HP:0011710)3.92592121
31Acute necrotizing encephalopathy (HP:0006965)3.85247404
32Abnormal mitochondria in muscle tissue (HP:0008316)3.84860626
33Absent phalangeal crease (HP:0006109)3.70398850
34Ventricular arrhythmia (HP:0004308)3.67519651
35Asymmetric septal hypertrophy (HP:0001670)3.63968221
36Deformed tarsal bones (HP:0008119)3.63111572
37Muscle fiber inclusion bodies (HP:0100299)3.55684838
38Hepatic necrosis (HP:0002605)3.50277563
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.48249442
40Heart block (HP:0012722)3.45049714
41Frequent falls (HP:0002359)3.37305030
42Increased connective tissue (HP:0009025)3.27951813
43EMG: neuropathic changes (HP:0003445)3.24249601
44Abnormal atrioventricular conduction (HP:0005150)3.22872040
45Acute encephalopathy (HP:0006846)3.21132876
46Progressive macrocephaly (HP:0004481)3.16487865
47Malignant hyperthermia (HP:0002047)3.07704721
48Abnormal finger flexion creases (HP:0006143)3.07459361
49Myotonia (HP:0002486)3.06630792
50Nemaline bodies (HP:0003798)3.05885449
51Mitochondrial inheritance (HP:0001427)3.04021268
52Atrioventricular block (HP:0001678)3.03805240
53Distal lower limb muscle weakness (HP:0009053)3.02310163
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99863800
55Abnormality of alanine metabolism (HP:0010916)2.99863800
56Hyperalaninemia (HP:0003348)2.99863800
57Difficulty running (HP:0009046)2.97384102
58Exercise intolerance (HP:0003546)2.95489290
59Abnormal EKG (HP:0003115)2.95339405
60Increased CSF lactate (HP:0002490)2.94537127
61Hepatocellular necrosis (HP:0001404)2.92079396
62Type 1 muscle fiber predominance (HP:0003803)2.91713086
63Left ventricular hypertrophy (HP:0001712)2.90504326
64Hypoglycemic coma (HP:0001325)2.89245805
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.82093641
66Dicarboxylic aciduria (HP:0003215)2.82093641
67Muscle stiffness (HP:0003552)2.76929581
68Fetal akinesia sequence (HP:0001989)2.76921718
69Ventricular fibrillation (HP:0001663)2.76492378
70Cerebral edema (HP:0002181)2.74781756
71Mildly elevated creatine phosphokinase (HP:0008180)2.67045885
72Abnormality of fatty-acid metabolism (HP:0004359)2.62076003
73Increased muscle lipid content (HP:0009058)2.59940347
74Neck muscle weakness (HP:0000467)2.58902268
75Areflexia of lower limbs (HP:0002522)2.57241566
76Lactic acidosis (HP:0003128)2.54111588
77Gowers sign (HP:0003391)2.48194836
78Bulbar palsy (HP:0001283)2.45590252
79Palmoplantar keratoderma (HP:0000982)2.45177966
80Distal lower limb amyotrophy (HP:0008944)2.43995133
81Weak cry (HP:0001612)2.41345075
82Generalized aminoaciduria (HP:0002909)2.37587771
83Progressive muscle weakness (HP:0003323)2.36417658
84Scapular winging (HP:0003691)2.35769404
85Slender build (HP:0001533)2.35360837
86Increased intramyocellular lipid droplets (HP:0012240)2.29992429
87Rimmed vacuoles (HP:0003805)2.29514122
88Abnormality of the calcaneus (HP:0008364)2.29289293
89Generalized muscle weakness (HP:0003324)2.28977051
90Respiratory failure (HP:0002878)2.27607130
91Ketoacidosis (HP:0001993)2.26619699
92Hip contracture (HP:0003273)2.23233150
93Abnormality of skeletal muscle fiber size (HP:0012084)2.22131428
94Fatigable weakness (HP:0003473)2.21670976
95Abnormality of the neuromuscular junction (HP:0003398)2.21670976
96Difficulty climbing stairs (HP:0003551)2.20584954
97Increased variability in muscle fiber diameter (HP:0003557)2.17395528
98Ragged-red muscle fibers (HP:0003200)2.15964436
99Renal cortical cysts (HP:0000803)2.15265494
100Abnormality of the foot musculature (HP:0001436)2.15257934
101Hyperkalemia (HP:0002153)2.12168657
102Conjunctival hamartoma (HP:0100780)2.11262521
103Nausea (HP:0002018)2.10781771
104Lipid accumulation in hepatocytes (HP:0006561)2.09368557
105Neuroendocrine neoplasm (HP:0100634)2.09126148
106Neoplasm of the adrenal gland (HP:0100631)2.09096818
107Double outlet right ventricle (HP:0001719)2.05050114
108Congenital malformation of the right heart (HP:0011723)2.05050114
109Proximal amyotrophy (HP:0007126)2.04738393
110Neoplasm of head and neck (HP:0012288)2.04648485
111Esophageal neoplasm (HP:0100751)2.04648485
112Spinal rigidity (HP:0003306)2.00924057
113Pheochromocytoma (HP:0002666)1.99291872
114Increased serum pyruvate (HP:0003542)1.98995355
115Abnormality of glycolysis (HP:0004366)1.98995355
116Waddling gait (HP:0002515)1.97115419
117Abnormality of the shoulder girdle musculature (HP:0001435)1.96789789
118Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96379351
119Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96379351
120Foot dorsiflexor weakness (HP:0009027)1.93642633
121Muscular dystrophy (HP:0003560)1.92571207
122Facial diplegia (HP:0001349)1.92091571
123Limb-girdle muscle atrophy (HP:0003797)1.91473015
124Congestive heart failure (HP:0001635)1.90135356
125Lower limb amyotrophy (HP:0007210)1.89617253
126Testicular atrophy (HP:0000029)1.89068404
127Increased serum lactate (HP:0002151)1.88918459
128Tinnitus (HP:0000360)1.88711245
129Centrally nucleated skeletal muscle fibers (HP:0003687)1.86966572
130Hypoplastic left heart (HP:0004383)1.86412763
131Proximal tubulopathy (HP:0000114)1.84219245
132Toxemia of pregnancy (HP:0100603)1.83677008
133Respiratory insufficiency due to muscle weakness (HP:0002747)1.82849214
134Popliteal pterygium (HP:0009756)1.82582868
135Abnormality of the hip-girdle musculature (HP:0001445)1.78178784
136Abnormality of the musculature of the pelvis (HP:0001469)1.78178784
137Metatarsus adductus (HP:0001840)1.74556372
138Long clavicles (HP:0000890)1.70849307
139Limb-girdle muscle weakness (HP:0003325)1.67994435
140Shoulder girdle muscle weakness (HP:0003547)1.66340357
141Type 2 muscle fiber atrophy (HP:0003554)1.66309715
142Pelvic girdle muscle weakness (HP:0003749)1.64172562
143Ulnar deviation of finger (HP:0009465)1.59977561
144Steppage gait (HP:0003376)1.54782199
145Nonprogressive disorder (HP:0003680)1.51259030
146Muscle fiber atrophy (HP:0100295)1.50024949
147Oligomenorrhea (HP:0000876)1.49820014
148Limited hip movement (HP:0008800)1.48969945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.17095127
2TTN4.77143765
3MYLK3.58171453
4PHKG23.43746700
5PHKG13.43746700
6STK243.09587122
7PDK43.06263230
8PDK33.06263230
9TIE12.73125225
10ZAK2.62661665
11PIK3CA2.57512158
12LMTK22.52621356
13BCKDK2.34919984
14MUSK2.28435394
15STK162.26507827
16PINK12.24552493
17DMPK2.19824840
18PDK22.01950315
19PKN22.00132109
20GRK71.99058994
21STK38L1.85017058
22NEK11.71475017
23TRPM71.56271531
24INSRR1.43678340
25NEK91.33990119
26PRKAA21.21347913
27MARK11.20853827
28FLT31.20663923
29MAP2K41.15335508
30LIMK11.14685764
31STK41.07840211
32MAP3K71.06071872
33PIK3CG1.05934361
34CAMK2D1.00671501
35MAPK121.00029360
36CDC42BPA0.97580260
37PRKAA10.96287685
38PRPF4B0.93489715
39IRAK30.89687404
40ILK0.89126773
41TRIB30.84387860
42PRKD10.83396969
43MAP2K30.83255357
44EEF2K0.82685930
45TGFBR20.80597183
46DYRK1B0.78548272
47CAMK40.77727869
48MOS0.73764296
49NME20.72231901
50RIPK10.68784865
51TXK0.65828387
52PAK30.64946497
53CAMK10.61256611
54RPS6KC10.60555269
55RPS6KL10.60555269
56ERBB30.60483535
57ROCK10.59106912
58SGK20.56412688
59PKN10.56198488
60RPS6KA60.56191897
61LATS10.56111389
62IRAK40.55626040
63MAP3K140.55440403
64MAP3K50.54945747
65NME10.53703080
66MAPK40.49292083
67EIF2AK20.48290077
68MAP2K10.47578184
69PRKCE0.46825566
70MAP3K130.46384476
71CAMK2B0.46210256
72NUAK10.45154391
73AKT20.44074280
74CAMK2A0.42801531
75MAP3K30.41047894
76PRKACA0.40206950
77PRKACB0.39926065
78KSR20.39492095
79MAPKAPK30.38944411
80TEC0.38842872
81CAMK1D0.38289373
82MAPK70.36965688
83DAPK30.35846694
84SGK30.34626845
85MAPK110.32515186
86TAOK20.31613002
87SGK10.29846088
88MAPK130.29570554
89PRKG10.29477687
90PRKACG0.29112568
91STK380.29042551
92JAK10.28862663
93RPS6KA30.28648033
94WNK40.26997879
95WNK10.24359799
96LATS20.23719358
97CAMK2G0.22411787
98PRKCQ0.22214097
99CCNB10.21212472
100MAPK100.21173980
101KDR0.20620723
102RPS6KB10.20383195
103TBK10.19711544
104RPS6KB20.19462789
105STK30.18821001
106DAPK20.18400964
107MARK30.18226197
108ADRBK20.16992426
109STK110.16601187
110KIT0.15893103
111MAP3K60.15362349
112MAP3K10.15113265
113RPS6KA10.14729216
114ICK0.14104544
115MAP2K60.13440911
116AKT10.13372585
117BRSK20.13196752
118PTK2B0.13003760
119RPS6KA20.12404780
120JAK30.11182108
121EPHA30.11179404
122MAP3K40.11067001
123MAP4K10.11045464
124PDK10.10894470
125MAPK150.10871253
126BMPR1B0.10798222
127MAP3K100.10611237
128TNIK0.09948505
129ZAP700.09842162
130FGFR30.08914669
131CDK190.08700250
132PDPK10.08630653
133SGK4940.08539828
134SGK2230.08539828
135KSR10.08403652
136RAF10.08108643
137MARK20.07530746
138MTOR0.06930490
139NLK0.05556335
140EPHB10.04769598
141ROCK20.02216868
142MAPK90.01944068

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.41402122
2Cardiac muscle contraction_Homo sapiens_hsa042604.39151790
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.98529413
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.70989784
5Propanoate metabolism_Homo sapiens_hsa006403.70715087
6Parkinsons disease_Homo sapiens_hsa050123.69147430
7Dilated cardiomyopathy_Homo sapiens_hsa054143.58828064
8Oxidative phosphorylation_Homo sapiens_hsa001903.57759160
9Fatty acid degradation_Homo sapiens_hsa000712.96765256
10Alzheimers disease_Homo sapiens_hsa050102.61975106
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.56024516
12Carbon metabolism_Homo sapiens_hsa012002.47553916
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46075043
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.41296674
15Huntingtons disease_Homo sapiens_hsa050162.40863129
16Fatty acid metabolism_Homo sapiens_hsa012122.21217496
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81265411
18Pyruvate metabolism_Homo sapiens_hsa006201.67645400
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60167334
20Viral myocarditis_Homo sapiens_hsa054161.57553329
21Starch and sucrose metabolism_Homo sapiens_hsa005001.49426182
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43179944
23Fatty acid elongation_Homo sapiens_hsa000621.38621124
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26062953
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20893060
26PPAR signaling pathway_Homo sapiens_hsa033201.14899067
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08699010
28Nitrogen metabolism_Homo sapiens_hsa009101.07303930
29Butanoate metabolism_Homo sapiens_hsa006501.05402461
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.02428410
31Glucagon signaling pathway_Homo sapiens_hsa049221.01562098
32Adipocytokine signaling pathway_Homo sapiens_hsa049200.98096542
33Insulin resistance_Homo sapiens_hsa049310.96870366
34beta-Alanine metabolism_Homo sapiens_hsa004100.96209449
35Gastric acid secretion_Homo sapiens_hsa049710.93347898
36Galactose metabolism_Homo sapiens_hsa000520.92759429
37cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91317012
38Fructose and mannose metabolism_Homo sapiens_hsa000510.84295592
39Biosynthesis of amino acids_Homo sapiens_hsa012300.84002465
40Insulin signaling pathway_Homo sapiens_hsa049100.83112244
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82340255
42Peroxisome_Homo sapiens_hsa041460.80865352
43Calcium signaling pathway_Homo sapiens_hsa040200.79950209
44AMPK signaling pathway_Homo sapiens_hsa041520.76913528
45GnRH signaling pathway_Homo sapiens_hsa049120.70550891
46HIF-1 signaling pathway_Homo sapiens_hsa040660.69512246
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67275393
48Lysine degradation_Homo sapiens_hsa003100.66347908
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65568017
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63941285
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62995428
52Long-term potentiation_Homo sapiens_hsa047200.62910330
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62674637
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61778631
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56382463
56Tryptophan metabolism_Homo sapiens_hsa003800.51966688
57Circadian rhythm_Homo sapiens_hsa047100.50375290
58Arginine and proline metabolism_Homo sapiens_hsa003300.47663161
59Salivary secretion_Homo sapiens_hsa049700.45488838
60Fatty acid biosynthesis_Homo sapiens_hsa000610.45435698
61Metabolic pathways_Homo sapiens_hsa011000.44699895
62Oxytocin signaling pathway_Homo sapiens_hsa049210.43516856
63Phenylalanine metabolism_Homo sapiens_hsa003600.43446181
64Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42823175
65Focal adhesion_Homo sapiens_hsa045100.42191502
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.36630548
67MAPK signaling pathway_Homo sapiens_hsa040100.34859455
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34303770
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32772307
70Cholinergic synapse_Homo sapiens_hsa047250.32117515
71Amphetamine addiction_Homo sapiens_hsa050310.31950088
72Long-term depression_Homo sapiens_hsa047300.30974022
73Arachidonic acid metabolism_Homo sapiens_hsa005900.28966048
74Type II diabetes mellitus_Homo sapiens_hsa049300.28295089
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.28234447
76Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27969308
77Tight junction_Homo sapiens_hsa045300.26534568
78Olfactory transduction_Homo sapiens_hsa047400.26502808
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.25835723
80Pancreatic secretion_Homo sapiens_hsa049720.25427375
81cAMP signaling pathway_Homo sapiens_hsa040240.21999970
82mTOR signaling pathway_Homo sapiens_hsa041500.21281466
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21052743
84Adherens junction_Homo sapiens_hsa045200.17980826
85ECM-receptor interaction_Homo sapiens_hsa045120.17973677
86Purine metabolism_Homo sapiens_hsa002300.17824504
87Phototransduction_Homo sapiens_hsa047440.17191335
88FoxO signaling pathway_Homo sapiens_hsa040680.17144435
89ABC transporters_Homo sapiens_hsa020100.15900670
90RNA degradation_Homo sapiens_hsa030180.15059220
91Regulation of autophagy_Homo sapiens_hsa041400.14587664
92Renin secretion_Homo sapiens_hsa049240.13899083
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13228954
94Melanogenesis_Homo sapiens_hsa049160.13151324
95Dopaminergic synapse_Homo sapiens_hsa047280.13053377
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.12781836
97Histidine metabolism_Homo sapiens_hsa003400.12649416
98Pentose phosphate pathway_Homo sapiens_hsa000300.11682260
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.11437724
100Bile secretion_Homo sapiens_hsa049760.11124499
101Amoebiasis_Homo sapiens_hsa051460.11077063
102VEGF signaling pathway_Homo sapiens_hsa043700.10667587
103Autoimmune thyroid disease_Homo sapiens_hsa053200.10447568
104Toxoplasmosis_Homo sapiens_hsa051450.10014034
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.09763847
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.09664160
107Oocyte meiosis_Homo sapiens_hsa041140.08696515
108Glioma_Homo sapiens_hsa052140.08391854
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.08060273
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.06370879
111Platelet activation_Homo sapiens_hsa046110.06184496
112Legionellosis_Homo sapiens_hsa051340.05681483
113Ovarian steroidogenesis_Homo sapiens_hsa049130.05648525
114Tyrosine metabolism_Homo sapiens_hsa003500.05625193
115Homologous recombination_Homo sapiens_hsa034400.04729338
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.02381597
117Notch signaling pathway_Homo sapiens_hsa043300.01149985
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.00983519
119Glycerolipid metabolism_Homo sapiens_hsa005610.00766947
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.00142252
121Arginine biosynthesis_Homo sapiens_hsa00220-0.0587500
122Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0574105
123Graft-versus-host disease_Homo sapiens_hsa05332-0.0561777
124RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0526488
125Allograft rejection_Homo sapiens_hsa05330-0.0524680
126PI3K-Akt signaling pathway_Homo sapiens_hsa04151-0.0501812
127Insulin secretion_Homo sapiens_hsa04911-0.0370844
128Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0343469
129Measles_Homo sapiens_hsa05162-0.0265874
130Circadian entrainment_Homo sapiens_hsa04713-0.0225369

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