LRRC37B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1centriole replication (GO:0007099)4.37584258
2protein polyglutamylation (GO:0018095)4.32296506
3establishment of protein localization to Golgi (GO:0072600)4.22607454
4sperm motility (GO:0030317)4.21543494
5negative regulation of mast cell activation (GO:0033004)4.19276596
6acrosome reaction (GO:0007340)4.15213409
7response to pheromone (GO:0019236)4.13322164
8protein targeting to Golgi (GO:0000042)3.97443636
9retrograde transport, vesicle recycling within Golgi (GO:0000301)3.73166764
10epithelial cilium movement (GO:0003351)3.71111311
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59095944
12behavioral response to nicotine (GO:0035095)3.55035462
13axoneme assembly (GO:0035082)3.46092582
14piRNA metabolic process (GO:0034587)3.42946160
15regulation of cilium movement (GO:0003352)3.39276138
16cilium or flagellum-dependent cell motility (GO:0001539)3.35051147
17activated T cell proliferation (GO:0050798)3.22596061
18cell wall macromolecule catabolic process (GO:0016998)3.19005861
19protein localization to Golgi apparatus (GO:0034067)3.18755151
20cilium movement (GO:0003341)3.18032468
21seminiferous tubule development (GO:0072520)3.14981961
22neural tube formation (GO:0001841)3.14926052
23regulation of B cell receptor signaling pathway (GO:0050855)3.07826134
24multicellular organism reproduction (GO:0032504)3.02548918
25centriole assembly (GO:0098534)2.96114670
26calcium ion-dependent exocytosis (GO:0017156)2.89885437
27DNA deamination (GO:0045006)2.89337861
28spermatid development (GO:0007286)2.87770635
29positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.87739703
30behavioral response to ethanol (GO:0048149)2.86686640
31L-fucose catabolic process (GO:0042355)2.83684842
32fucose catabolic process (GO:0019317)2.83684842
33L-fucose metabolic process (GO:0042354)2.83684842
34negative regulation of cytosolic calcium ion concentration (GO:0051481)2.79845970
35neuronal action potential (GO:0019228)2.79597204
36cell wall macromolecule metabolic process (GO:0044036)2.79481905
37cilium organization (GO:0044782)2.78399052
38cilium assembly (GO:0042384)2.73888918
39histone H3-K9 methylation (GO:0051567)2.68356732
40presynaptic membrane assembly (GO:0097105)2.65726448
41somite development (GO:0061053)2.65544300
42microtubule depolymerization (GO:0007019)2.63167818
43single strand break repair (GO:0000012)2.61638411
44DNA methylation involved in gamete generation (GO:0043046)2.60594515
45intraciliary transport (GO:0042073)2.56803892
46histone H3-K4 trimethylation (GO:0080182)2.56559499
47mast cell activation involved in immune response (GO:0002279)2.56452327
48mast cell degranulation (GO:0043303)2.56452327
49limb development (GO:0060173)2.56082053
50appendage development (GO:0048736)2.56082053
51detection of light stimulus involved in visual perception (GO:0050908)2.54916784
52detection of light stimulus involved in sensory perception (GO:0050962)2.54916784
53spinal cord motor neuron differentiation (GO:0021522)2.54239631
54adaptation of signaling pathway (GO:0023058)2.51060016
55protein K11-linked deubiquitination (GO:0035871)2.48822133
56pyrimidine nucleobase catabolic process (GO:0006208)2.47749741
57replication fork processing (GO:0031297)2.47111691
58regulation of action potential (GO:0098900)2.47053178
59regulation of memory T cell differentiation (GO:0043380)2.46665634
60regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.46421925
61positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.46421925
62positive regulation of mast cell activation involved in immune response (GO:0033008)2.45643881
63positive regulation of mast cell degranulation (GO:0043306)2.45643881
64peptidyl-lysine trimethylation (GO:0018023)2.45565549
65cilium morphogenesis (GO:0060271)2.45356724
66photoreceptor cell maintenance (GO:0045494)2.44556508
67phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42817625
68positive regulation of mast cell activation (GO:0033005)2.42723523
69membrane depolarization during action potential (GO:0086010)2.42112513
70inositol phosphate catabolic process (GO:0071545)2.41893653
71ionotropic glutamate receptor signaling pathway (GO:0035235)2.41297766
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40907733
73regulation of telomere maintenance (GO:0032204)2.40600969
74regulation of mast cell activation (GO:0033003)2.39144649
75axonemal dynein complex assembly (GO:0070286)2.38599669
76protein localization to cilium (GO:0061512)2.38022549
77regulation of microtubule-based movement (GO:0060632)2.37535471
78histone H3-K9 modification (GO:0061647)2.37531508
79nonmotile primary cilium assembly (GO:0035058)2.36610549
80RNA destabilization (GO:0050779)2.36297959
81presynaptic membrane organization (GO:0097090)2.35572499
82negative regulation of neurotransmitter transport (GO:0051589)2.34620518
83regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.31052223
84positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.31052223
85phosphatidylethanolamine metabolic process (GO:0046337)2.30011363
86fusion of sperm to egg plasma membrane (GO:0007342)2.28808094
87tachykinin receptor signaling pathway (GO:0007217)2.28513652
88postsynaptic membrane organization (GO:0001941)2.28343556
89mast cell activation (GO:0045576)2.28249771
90cellular ketone body metabolic process (GO:0046950)2.27195306
91cornea development in camera-type eye (GO:0061303)2.26783782
92phosphorelay signal transduction system (GO:0000160)2.26662589
93male meiosis (GO:0007140)2.26496759
94transmission of nerve impulse (GO:0019226)2.26081837
95alanine transport (GO:0032328)2.25957801
96negative regulation of translation, ncRNA-mediated (GO:0040033)2.25743238
97regulation of translation, ncRNA-mediated (GO:0045974)2.25743238
98negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.25743238
99monoubiquitinated protein deubiquitination (GO:0035520)2.25435372
100startle response (GO:0001964)2.24839934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.67478076
2ZNF274_21170338_ChIP-Seq_K562_Hela3.20137811
3GBX2_23144817_ChIP-Seq_PC3_Human3.15471889
4VDR_22108803_ChIP-Seq_LS180_Human2.84101416
5IGF1R_20145208_ChIP-Seq_DFB_Human2.72978387
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.56392289
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54808731
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.40414860
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.39766480
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38101298
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27935682
12FUS_26573619_Chip-Seq_HEK293_Human2.22521758
13TAF15_26573619_Chip-Seq_HEK293_Human2.18373313
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.15183564
15ER_23166858_ChIP-Seq_MCF-7_Human2.08660258
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02375880
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98667802
18P300_19829295_ChIP-Seq_ESCs_Human1.97664993
19EWS_26573619_Chip-Seq_HEK293_Human1.84748551
20TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76530437
21POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.76530437
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.75732558
23CBP_20019798_ChIP-Seq_JUKART_Human1.69519813
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69519813
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65364749
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64725881
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.64672649
28SMAD4_21799915_ChIP-Seq_A2780_Human1.64540784
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63877394
30STAT3_23295773_ChIP-Seq_U87_Human1.61131459
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60283138
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53086967
33AR_21572438_ChIP-Seq_LNCaP_Human1.51835292
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51160157
35AR_25329375_ChIP-Seq_VCAP_Human1.49798476
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.49045783
37SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46581115
38TCF4_23295773_ChIP-Seq_U87_Human1.45970466
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44706053
40BCAT_22108803_ChIP-Seq_LS180_Human1.44203518
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43493531
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42322270
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41786524
44STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40836780
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.40756121
46TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.40365528
47RUNX2_22187159_ChIP-Seq_PCA_Human1.37763096
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.36131689
49REST_21632747_ChIP-Seq_MESCs_Mouse1.34389758
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32413101
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.31789542
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31607992
53IRF1_19129219_ChIP-ChIP_H3396_Human1.29990993
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29775050
55TCF4_22108803_ChIP-Seq_LS180_Human1.23983885
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22421586
57HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21921050
58TP53_22573176_ChIP-Seq_HFKS_Human1.21723627
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20880301
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20878414
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.20517045
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.19946553
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18872630
64RUNX_20019798_ChIP-Seq_JUKART_Human1.18328865
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.17235900
66RNF2_27304074_Chip-Seq_NSC_Mouse1.16122973
67NANOG_19829295_ChIP-Seq_ESCs_Human1.15904710
68SOX2_19829295_ChIP-Seq_ESCs_Human1.15904710
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.15201075
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12905024
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12688633
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10929847
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.10929847
74* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10313539
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10054059
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.09459975
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08358937
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.08261142
79IRF8_22096565_ChIP-ChIP_GC-B_Human1.07936999
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.07877037
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05813269
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05140699
83WDR5_24793694_ChIP-Seq_LNCAP_Human1.04796919
84* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04530776
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04258623
86DROSHA_22980978_ChIP-Seq_HELA_Human1.01104289
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99764262
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.99095016
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99026247
90TAL1_26923725_Chip-Seq_HPCs_Mouse0.98272959
91P53_22387025_ChIP-Seq_ESCs_Mouse0.97709659
92REST_18959480_ChIP-ChIP_MESCs_Mouse0.97570648
93* GATA3_26560356_Chip-Seq_TH2_Human0.97553909
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97496173
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97430381
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.97296605
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.96518143
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94987986
99KDM2B_26808549_Chip-Seq_REH_Human0.93978293
100SMRT_27268052_Chip-Seq_Bcells_Human0.93469082

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.70989671
2MP0008877_abnormal_DNA_methylation3.47055564
3MP0000569_abnormal_digit_pigmentation2.69301301
4MP0005410_abnormal_fertilization2.59441403
5MP0001968_abnormal_touch/_nociception2.41537608
6MP0006292_abnormal_olfactory_placode2.30069786
7MP0003880_abnormal_central_pattern2.21398432
8MP0001486_abnormal_startle_reflex2.11002050
9MP0002102_abnormal_ear_morphology2.06771179
10MP0009046_muscle_twitch1.94392496
11MP0005551_abnormal_eye_electrophysiolog1.91420912
12MP0009745_abnormal_behavioral_response1.82715868
13MP0005645_abnormal_hypothalamus_physiol1.82378791
14MP0005646_abnormal_pituitary_gland1.79813246
15MP0004142_abnormal_muscle_tone1.71608762
16MP0003646_muscle_fatigue1.68741044
17MP0005423_abnormal_somatic_nervous1.66246272
18MP0005174_abnormal_tail_pigmentation1.65653021
19MP0002272_abnormal_nervous_system1.64854895
20MP0003635_abnormal_synaptic_transmissio1.64115825
21MP0002736_abnormal_nociception_after1.61702146
22MP0005075_abnormal_melanosome_morpholog1.61551041
23MP0003121_genomic_imprinting1.57474261
24MP0002638_abnormal_pupillary_reflex1.55839706
25MP0003698_abnormal_male_reproductive1.53690217
26MP0002733_abnormal_thermal_nociception1.52511337
27MP0002735_abnormal_chemical_nociception1.51803197
28MP0001986_abnormal_taste_sensitivity1.49637776
29MP0006072_abnormal_retinal_apoptosis1.45791648
30MP0001501_abnormal_sleep_pattern1.45631911
31MP0003195_calcinosis1.44696613
32MP0003122_maternal_imprinting1.44687290
33MP0001485_abnormal_pinna_reflex1.44069134
34MP0006276_abnormal_autonomic_nervous1.42178708
35MP0005253_abnormal_eye_physiology1.40297601
36MP0002572_abnormal_emotion/affect_behav1.39525690
37MP0001929_abnormal_gametogenesis1.38058002
38MP0001970_abnormal_pain_threshold1.37626105
39MP0004742_abnormal_vestibular_system1.37117510
40MP0002064_seizures1.36807696
41MP0004885_abnormal_endolymph1.33964791
42MP0002653_abnormal_ependyma_morphology1.33250595
43MP0002067_abnormal_sensory_capabilities1.33117544
44MP0005671_abnormal_response_to1.32402243
45MP0008872_abnormal_physiological_respon1.29372749
46MP0002063_abnormal_learning/memory/cond1.26976359
47MP0000372_irregular_coat_pigmentation1.26167341
48MP0000631_abnormal_neuroendocrine_gland1.24012704
49MP0001188_hyperpigmentation1.21591571
50MP0001984_abnormal_olfaction1.21073528
51MP0002557_abnormal_social/conspecific_i1.16669462
52MP0002138_abnormal_hepatobiliary_system1.15854931
53MP0005386_behavior/neurological_phenoty1.15510456
54MP0004924_abnormal_behavior1.15510456
55MP0002095_abnormal_skin_pigmentation1.13024841
56MP0008995_early_reproductive_senescence1.12629310
57MP0003183_abnormal_peptide_metabolism1.08808151
58MP0000015_abnormal_ear_pigmentation1.08695582
59MP0003878_abnormal_ear_physiology1.07875717
60MP0005377_hearing/vestibular/ear_phenot1.07875717
61MP0000427_abnormal_hair_cycle1.07823401
62MP0002822_catalepsy1.06909127
63MP0000778_abnormal_nervous_system1.03072133
64MP0008057_abnormal_DNA_replication1.01779082
65MP0005084_abnormal_gallbladder_morpholo0.98641629
66MP0003763_abnormal_thymus_physiology0.96342850
67MP0003633_abnormal_nervous_system0.95535791
68MP0003011_delayed_dark_adaptation0.90625601
69MP0002734_abnormal_mechanical_nocicepti0.89933672
70MP0001919_abnormal_reproductive_system0.89409636
71MP0004133_heterotaxia0.89020662
72MP0002229_neurodegeneration0.88712419
73MP0004859_abnormal_synaptic_plasticity0.87842909
74MP0002928_abnormal_bile_duct0.87397210
75MP0000955_abnormal_spinal_cord0.86101727
76MP0008058_abnormal_DNA_repair0.85875693
77MP0002184_abnormal_innervation0.84613281
78MP0001502_abnormal_circadian_rhythm0.84559328
79MP0002210_abnormal_sex_determination0.83551162
80MP0002751_abnormal_autonomic_nervous0.83148404
81MP0001800_abnormal_humoral_immune0.82882117
82MP0004147_increased_porphyrin_level0.82239950
83MP0000653_abnormal_sex_gland0.82234601
84MP0008789_abnormal_olfactory_epithelium0.81993813
85MP0001963_abnormal_hearing_physiology0.81780423
86MP0005389_reproductive_system_phenotype0.80414054
87MP0002277_abnormal_respiratory_mucosa0.80179972
88MP0001324_abnormal_eye_pigmentation0.80052365
89MP0001145_abnormal_male_reproductive0.78317264
90MP0008961_abnormal_basal_metabolism0.77581350
91MP0002693_abnormal_pancreas_physiology0.75131927
92MP0002882_abnormal_neuron_morphology0.74290984
93MP0002234_abnormal_pharynx_morphology0.74240933
94MP0005379_endocrine/exocrine_gland_phen0.73067837
95MP0003724_increased_susceptibility_to0.72299935
96MP0010386_abnormal_urinary_bladder0.72179497
97MP0003631_nervous_system_phenotype0.72112083
98MP0005394_taste/olfaction_phenotype0.70133765
99MP0005499_abnormal_olfactory_system0.70133765
100MP0004145_abnormal_muscle_electrophysio0.69927085

Predicted human phenotypes

RankGene SetZ-score
1Nephronophthisis (HP:0000090)3.90366545
2Pancreatic cysts (HP:0001737)3.80863877
3Abnormality of midbrain morphology (HP:0002418)3.74956357
4Molar tooth sign on MRI (HP:0002419)3.74956357
5True hermaphroditism (HP:0010459)3.67265498
6Chronic hepatic failure (HP:0100626)3.53736113
7Pancreatic fibrosis (HP:0100732)3.51228802
8Medial flaring of the eyebrow (HP:0010747)3.26237422
9Abnormality of the renal medulla (HP:0100957)3.24848551
10Genetic anticipation (HP:0003743)3.22712502
11Hyperventilation (HP:0002883)3.19049295
12Progressive cerebellar ataxia (HP:0002073)2.98632589
13Congenital stationary night blindness (HP:0007642)2.91957027
14Dynein arm defect of respiratory motile cilia (HP:0012255)2.91631159
15Absent/shortened dynein arms (HP:0200106)2.91631159
16Stomach cancer (HP:0012126)2.80264211
17Abnormality of the renal cortex (HP:0011035)2.79570930
18Febrile seizures (HP:0002373)2.77594235
19Gaze-evoked nystagmus (HP:0000640)2.72118444
20Type II lissencephaly (HP:0007260)2.68093725
21Gait imbalance (HP:0002141)2.66437902
22Nephrogenic diabetes insipidus (HP:0009806)2.58325281
23Abnormal rod and cone electroretinograms (HP:0008323)2.56912044
24Abolished electroretinogram (ERG) (HP:0000550)2.55156300
25Focal motor seizures (HP:0011153)2.54526681
26Congenital primary aphakia (HP:0007707)2.54324826
27Attenuation of retinal blood vessels (HP:0007843)2.37918444
28Cystic liver disease (HP:0006706)2.35153498
29Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34701984
30Neoplasm of the tracheobronchial system (HP:0100552)2.33864160
31Tubular atrophy (HP:0000092)2.30889016
32Tubulointerstitial nephritis (HP:0001970)2.30253353
33Severe visual impairment (HP:0001141)2.29599584
34Inability to walk (HP:0002540)2.25454638
35Absent speech (HP:0001344)2.24039924
36Abnormal ciliary motility (HP:0012262)2.23485505
37Volvulus (HP:0002580)2.22337589
38Renal cortical cysts (HP:0000803)2.21561265
39Polydipsia (HP:0001959)2.21445982
40Abnormal drinking behavior (HP:0030082)2.21445982
41Broad-based gait (HP:0002136)2.17851368
42Alveolar cell carcinoma (HP:0006519)2.17780968
43Thyroiditis (HP:0100646)2.17746121
44Cerebellar dysplasia (HP:0007033)2.16748083
45Optic nerve hypoplasia (HP:0000609)2.16341372
46Colon cancer (HP:0003003)2.14108797
47Congenital hepatic fibrosis (HP:0002612)2.13996937
48Intestinal atresia (HP:0011100)2.13616731
49Abnormal respiratory motile cilium morphology (HP:0005938)2.13565473
50Abnormal respiratory epithelium morphology (HP:0012253)2.13565473
51Progressive inability to walk (HP:0002505)2.12727089
52Poor coordination (HP:0002370)2.12509549
53Abnormal respiratory motile cilium physiology (HP:0012261)2.12451236
54Lissencephaly (HP:0001339)2.11989903
55Protruding tongue (HP:0010808)2.09927919
56Hemiparesis (HP:0001269)2.09588393
57Hypoplastic ischia (HP:0003175)2.05827121
58Neoplasm of the adrenal cortex (HP:0100641)2.00796690
59Severe combined immunodeficiency (HP:0004430)1.99531412
60Drooling (HP:0002307)1.98730608
61Genital tract atresia (HP:0001827)1.97499646
62Postaxial foot polydactyly (HP:0001830)1.91896758
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91442501
64Excessive salivation (HP:0003781)1.89576531
65Focal seizures (HP:0007359)1.89463637
66Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88452060
67Vaginal atresia (HP:0000148)1.87349217
68Bony spicule pigmentary retinopathy (HP:0007737)1.85801516
69Anencephaly (HP:0002323)1.85038416
70Truncal obesity (HP:0001956)1.84790972
71Male pseudohermaphroditism (HP:0000037)1.84228851
723-Methylglutaconic aciduria (HP:0003535)1.81374484
73Stomatitis (HP:0010280)1.81213341
74Retinal dysplasia (HP:0007973)1.80170360
75Widely spaced teeth (HP:0000687)1.80059450
76Sclerocornea (HP:0000647)1.79573692
77Bile duct proliferation (HP:0001408)1.78065608
78Abnormal biliary tract physiology (HP:0012439)1.78065608
79Abnormality of macular pigmentation (HP:0008002)1.78052988
80Polyuria (HP:0000103)1.77567320
81Epileptic encephalopathy (HP:0200134)1.76884392
82Tubulointerstitial abnormality (HP:0001969)1.75956451
83Specific learning disability (HP:0001328)1.74481472
84Abnormality of the ischium (HP:0003174)1.73769758
85Decreased central vision (HP:0007663)1.72925341
86Abnormality of eosinophils (HP:0001879)1.72351605
87Postaxial hand polydactyly (HP:0001162)1.71402169
88Impulsivity (HP:0100710)1.70679493
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.68698511
90Pachygyria (HP:0001302)1.67446752
91Hypoplastic iliac wings (HP:0002866)1.66377329
92Panhypogammaglobulinemia (HP:0003139)1.65586460
93Growth hormone deficiency (HP:0000824)1.63612392
94Sloping forehead (HP:0000340)1.63235056
95Amyotrophic lateral sclerosis (HP:0007354)1.62988045
96Dialeptic seizures (HP:0011146)1.62623643
97Atonic seizures (HP:0010819)1.62435982
98Prominent nasal bridge (HP:0000426)1.61949220
99Hypochromic microcytic anemia (HP:0004840)1.59246945
100Large for gestational age (HP:0001520)1.57920771

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.79847677
2TAOK32.85559432
3BMPR1B2.72209023
4MAP4K22.66633981
5TXK2.58409573
6PINK12.58247930
7MAPK132.37926933
8NUAK12.26751434
9ADRBK22.08225623
10MAP3K41.93026294
11WNK31.87532438
12INSRR1.77342927
13PNCK1.76624497
14CASK1.70592912
15ACVR1B1.64126654
16CAMKK21.60546282
17SIK21.59637429
18PLK41.57100188
19MARK11.40657384
20MAP2K71.34346311
21SGK21.33406575
22GRK11.28821044
23TNK21.27095518
24TNIK1.25986713
25IRAK11.25161001
26TRIM281.24211063
27ZAK1.23257298
28NTRK31.19133438
29MARK31.18774080
30PLK21.15213146
31MAP4K11.12376775
32AKT31.08744867
33DYRK21.07621095
34TEC1.05768311
35BRD41.03752208
36CAMK1G1.02990406
37KIT1.02483414
38SGK4941.00985033
39SGK2231.00985033
40NTRK21.00311082
41CDK30.97904117
42DAPK20.94013014
43PIK3CG0.93891336
44PTK2B0.92127576
45EPHA30.90750605
46CSNK1G20.88683765
47MAPK150.85858256
48CDK190.85365053
49GRK60.84954194
50NLK0.83290288
51SYK0.81142743
52PAK30.79552238
53ITK0.78889386
54ADRBK10.77220991
55PRKCQ0.76473742
56FES0.75803190
57PRKCG0.73434899
58ERBB30.73106258
59CAMK10.71660522
60CAMK40.71467613
61IRAK40.70402070
62UHMK10.66885958
63CSNK1G30.66726518
64WNK40.62971997
65CAMKK10.62487850
66DYRK30.62473788
67PRKD30.62319714
68CSNK1G10.61575897
69VRK10.61569253
70IKBKB0.59301203
71BTK0.56787554
72CHUK0.55624138
73CSNK1A1L0.55307119
74NEK20.55298565
75PRKCE0.54008266
76BCR0.51399839
77IKBKE0.50955772
78STK110.49425047
79RPS6KA50.48291225
80DYRK1A0.48072884
81MAP2K40.47757796
82SIK30.47589485
83LYN0.47393777
84PKN10.46862007
85TLK10.46523438
86OXSR10.46355630
87STK30.45075675
88MKNK20.44991610
89SGK10.44189267
90CAMK1D0.44044586
91CSF1R0.43518224
92LCK0.43111634
93PIK3CA0.42803235
94HIPK20.41660344
95HCK0.41253283
96WNK10.40312284
97MAP2K60.38568343
98GRK70.38319250
99PRKG10.36836824
100SGK30.36079200

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.70436102
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69477578
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.30544374
4Olfactory transduction_Homo sapiens_hsa047402.16732059
5Butanoate metabolism_Homo sapiens_hsa006502.13412415
6Phototransduction_Homo sapiens_hsa047442.11615721
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.96404285
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90657019
9Taste transduction_Homo sapiens_hsa047421.81858042
10Circadian entrainment_Homo sapiens_hsa047131.80186100
11Dorso-ventral axis formation_Homo sapiens_hsa043201.65174756
12Fanconi anemia pathway_Homo sapiens_hsa034601.60152037
13Type I diabetes mellitus_Homo sapiens_hsa049401.58934641
14Nitrogen metabolism_Homo sapiens_hsa009101.58679707
15Basal transcription factors_Homo sapiens_hsa030221.56842505
16Asthma_Homo sapiens_hsa053101.55955958
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.55031853
18Long-term depression_Homo sapiens_hsa047301.54740775
19Regulation of autophagy_Homo sapiens_hsa041401.54147118
20Glutamatergic synapse_Homo sapiens_hsa047241.52584788
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51530064
22Primary immunodeficiency_Homo sapiens_hsa053401.47952218
23Graft-versus-host disease_Homo sapiens_hsa053321.47883131
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.47280599
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44664360
26Linoleic acid metabolism_Homo sapiens_hsa005911.44082603
27Morphine addiction_Homo sapiens_hsa050321.40098064
28Amphetamine addiction_Homo sapiens_hsa050311.36582633
29Allograft rejection_Homo sapiens_hsa053301.36063307
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31630835
31Dopaminergic synapse_Homo sapiens_hsa047281.27129773
32Autoimmune thyroid disease_Homo sapiens_hsa053201.24079770
33GABAergic synapse_Homo sapiens_hsa047271.19430828
34Salivary secretion_Homo sapiens_hsa049701.18978214
35Serotonergic synapse_Homo sapiens_hsa047261.16497655
36Insulin secretion_Homo sapiens_hsa049111.12456798
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12154502
38Ether lipid metabolism_Homo sapiens_hsa005651.11698084
39Renin secretion_Homo sapiens_hsa049241.08365922
40Homologous recombination_Homo sapiens_hsa034401.07119705
41Cholinergic synapse_Homo sapiens_hsa047251.06695444
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04023778
43Calcium signaling pathway_Homo sapiens_hsa040201.02231677
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02113055
45NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99079584
46ABC transporters_Homo sapiens_hsa020100.96717652
47T cell receptor signaling pathway_Homo sapiens_hsa046600.95833401
48RNA degradation_Homo sapiens_hsa030180.93434609
49Circadian rhythm_Homo sapiens_hsa047100.92681073
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90305911
51Oxytocin signaling pathway_Homo sapiens_hsa049210.88988746
52Type II diabetes mellitus_Homo sapiens_hsa049300.87670812
53Cocaine addiction_Homo sapiens_hsa050300.83705006
54cAMP signaling pathway_Homo sapiens_hsa040240.82905568
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80415596
56Antigen processing and presentation_Homo sapiens_hsa046120.79835519
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79504415
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74931445
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.74759742
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73301347
61Platelet activation_Homo sapiens_hsa046110.71470909
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70072579
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68653082
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.68332418
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.67582922
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.65118402
67Propanoate metabolism_Homo sapiens_hsa006400.63993875
68Fatty acid biosynthesis_Homo sapiens_hsa000610.63508787
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63073424
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61714009
71Inositol phosphate metabolism_Homo sapiens_hsa005620.60704436
72Arachidonic acid metabolism_Homo sapiens_hsa005900.59589690
73Gastric acid secretion_Homo sapiens_hsa049710.57189510
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56283255
75Long-term potentiation_Homo sapiens_hsa047200.56157417
76Hematopoietic cell lineage_Homo sapiens_hsa046400.55620738
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.55530566
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.54810382
79MAPK signaling pathway_Homo sapiens_hsa040100.53106420
80Protein export_Homo sapiens_hsa030600.52666152
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52061957
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50744673
83Peroxisome_Homo sapiens_hsa041460.50368397
84Chemokine signaling pathway_Homo sapiens_hsa040620.49311265
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.48671187
86Chemical carcinogenesis_Homo sapiens_hsa052040.47414359
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45417069
88B cell receptor signaling pathway_Homo sapiens_hsa046620.44678395
89Measles_Homo sapiens_hsa051620.44558151
90Tryptophan metabolism_Homo sapiens_hsa003800.43671275
91Non-homologous end-joining_Homo sapiens_hsa034500.43627672
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42832601
93Selenocompound metabolism_Homo sapiens_hsa004500.40442100
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40389454
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39662740
96African trypanosomiasis_Homo sapiens_hsa051430.39061558
97Ras signaling pathway_Homo sapiens_hsa040140.38091609
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37784516
99Rheumatoid arthritis_Homo sapiens_hsa053230.37265386
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36073186

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