LRRC37A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.92136266
2motile cilium assembly (GO:0044458)9.38173470
3spermatid development (GO:0007286)8.93825554
4cilium movement (GO:0003341)8.77365506
5regulation of cilium movement (GO:0003352)8.52308098
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.19480987
7single fertilization (GO:0007338)8.07968366
8piRNA metabolic process (GO:0034587)7.88868409
9male meiosis (GO:0007140)7.66269861
10sperm capacitation (GO:0048240)7.57129316
11synaptonemal complex organization (GO:0070193)6.77618685
12behavioral response to nicotine (GO:0035095)6.62193116
13fertilization (GO:0009566)6.54227818
14synaptonemal complex assembly (GO:0007130)6.52318070
15sulfation (GO:0051923)6.19250090
16microtubule depolymerization (GO:0007019)6.12865961
17ventricular system development (GO:0021591)5.91351797
18spermatogenesis (GO:0007283)5.74675448
19male gamete generation (GO:0048232)5.72589422
20cell proliferation in forebrain (GO:0021846)5.50377262
21organic cation transport (GO:0015695)5.41699472
22negative regulation of inclusion body assembly (GO:0090084)5.40760093
23gamete generation (GO:0007276)5.27928117
24calcium ion-dependent exocytosis (GO:0017156)5.23938588
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.19587294
26cell recognition (GO:0008037)5.14199163
27male meiosis I (GO:0007141)5.03814844
28germ cell development (GO:0007281)5.02072379
29regulation of microtubule-based movement (GO:0060632)4.96362428
30DNA methylation involved in gamete generation (GO:0043046)4.87762598
31spermatid nucleus differentiation (GO:0007289)4.68348317
32chromosome organization involved in meiosis (GO:0070192)4.64130201
33cellular response to ATP (GO:0071318)4.59209461
34regulation of inclusion body assembly (GO:0090083)4.56386471
35meiotic nuclear division (GO:0007126)4.42732262
36regulation of glomerulus development (GO:0090192)4.40138448
37microtubule severing (GO:0051013)4.32347514
38left/right pattern formation (GO:0060972)4.22213673
39multicellular organismal reproductive process (GO:0048609)4.18080664
40monoubiquitinated protein deubiquitination (GO:0035520)4.14429376
41meiosis I (GO:0007127)4.06711932
42regulation of cell proliferation involved in kidney development (GO:1901722)4.02048101
43kynurenine metabolic process (GO:0070189)3.99374677
44indole-containing compound catabolic process (GO:0042436)3.90720032
45indolalkylamine catabolic process (GO:0046218)3.90720032
46tryptophan catabolic process (GO:0006569)3.90720032
47glycerol ether metabolic process (GO:0006662)3.88636766
48water-soluble vitamin biosynthetic process (GO:0042364)3.78190043
49protein localization to cilium (GO:0061512)3.72052805
50seminiferous tubule development (GO:0072520)3.70778721
51positive regulation of fatty acid oxidation (GO:0046321)3.69732200
52regulation of sequestering of triglyceride (GO:0010889)3.67001853
53somite development (GO:0061053)3.64479887
54regulation of DNA endoreduplication (GO:0032875)3.64344012
55purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.61173970
563-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.61173970
57protein polyglutamylation (GO:0018095)3.60587074
58genitalia morphogenesis (GO:0035112)3.59990858
59negative regulation of systemic arterial blood pressure (GO:0003085)3.58796791
60ether metabolic process (GO:0018904)3.58379293
61indolalkylamine metabolic process (GO:0006586)3.53780146
62meiotic cell cycle (GO:0051321)3.52205700
63positive regulation of cAMP-mediated signaling (GO:0043950)3.51547163
64chaperone-mediated protein complex assembly (GO:0051131)3.49916855
65gamma-aminobutyric acid transport (GO:0015812)3.44799277
66regulation of gene silencing by RNA (GO:0060966)3.34637911
67regulation of posttranscriptional gene silencing (GO:0060147)3.34637911
68regulation of gene silencing by miRNA (GO:0060964)3.34637911
69centriole assembly (GO:0098534)3.34351056
70multicellular organismal development (GO:0007275)3.34264410
71tryptophan metabolic process (GO:0006568)3.31492948
72regulation of centriole replication (GO:0046599)3.30921098
73regulation of phospholipid biosynthetic process (GO:0071071)3.29936929
74otic vesicle formation (GO:0030916)3.29506703
75negative regulation of organelle assembly (GO:1902116)3.27960651
76microtubule polymerization or depolymerization (GO:0031109)3.26510784
77microtubule-based movement (GO:0007018)3.25619935
78intraciliary transport (GO:0042073)3.24262283
79regulation of collateral sprouting (GO:0048670)3.24120926
80dentate gyrus development (GO:0021542)3.22905799
81negative regulation of transcription regulatory region DNA binding (GO:2000678)3.22696955
82positive regulation of fatty acid beta-oxidation (GO:0032000)3.20157951
83mitochondrial respiratory chain complex I assembly (GO:0032981)3.19812751
84NADH dehydrogenase complex assembly (GO:0010257)3.19812751
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19812751
86membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.17902105
87cilium organization (GO:0044782)3.16316629
88centriole replication (GO:0007099)3.15062940
89cellular response to exogenous dsRNA (GO:0071360)3.12514275
90axoneme assembly (GO:0035082)3.07708594
91cilium assembly (GO:0042384)3.06867646
92negative regulation of mast cell activation (GO:0033004)3.05312684
93amino-acid betaine transport (GO:0015838)3.04565472
94carnitine transport (GO:0015879)3.04565472
95regulation of spindle checkpoint (GO:0090231)3.04485585
96DNA deamination (GO:0045006)3.02238787
97spinal cord motor neuron differentiation (GO:0021522)3.01470786
98fucose catabolic process (GO:0019317)3.01456749
99L-fucose metabolic process (GO:0042354)3.01456749
100L-fucose catabolic process (GO:0042355)3.01456749
101gene silencing by RNA (GO:0031047)2.98696010
102polyol catabolic process (GO:0046174)2.98631402
103chromosome condensation (GO:0030261)2.98541240
104regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.97062192
105cilium morphogenesis (GO:0060271)2.96114360
106cellular component assembly involved in morphogenesis (GO:0010927)2.94797373
107alditol metabolic process (GO:0019400)2.94672298
108nuclear pore complex assembly (GO:0051292)2.93504171
109limb bud formation (GO:0060174)2.91674784
110negative regulation of Rho protein signal transduction (GO:0035024)2.91396610
111carnitine transmembrane transport (GO:1902603)2.90665583
112response to UV-C (GO:0010225)2.90619596
113reflex (GO:0060004)2.90265279
114negative regulation of telomere maintenance (GO:0032205)2.89954182
115synapsis (GO:0007129)2.89107706
116indole-containing compound metabolic process (GO:0042430)2.88785369
117cellular anion homeostasis (GO:0030002)2.88233255
118protein K11-linked deubiquitination (GO:0035871)2.86316596
119positive regulation of metanephros development (GO:0072216)2.86157673
120regulation of meiosis I (GO:0060631)2.86114012
121DNA packaging (GO:0006323)2.85863627
122cellular biogenic amine catabolic process (GO:0042402)2.84085598
123amine catabolic process (GO:0009310)2.84085598
124flavonoid metabolic process (GO:0009812)2.84026868
125regulation of germinal center formation (GO:0002634)2.82111710
126negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82000512
127nucleoside diphosphate phosphorylation (GO:0006165)2.81974303
128regulation of action potential (GO:0098900)2.81687753
129meiotic cell cycle process (GO:1903046)2.79346411
130epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.76818805
131protein complex biogenesis (GO:0070271)2.76024657
132nucleus organization (GO:0006997)2.73736922
133left/right axis specification (GO:0070986)2.72676655
134lactate metabolic process (GO:0006089)2.72231384
135transmission of nerve impulse (GO:0019226)2.71769544
136musculoskeletal movement (GO:0050881)2.69795696
137multicellular organismal movement (GO:0050879)2.69795696
138cerebellar Purkinje cell differentiation (GO:0021702)2.69415193
139negative regulation of appetite (GO:0032099)2.68580480
140negative regulation of response to food (GO:0032096)2.68580480
141protein refolding (GO:0042026)2.65465683
142serotonin metabolic process (GO:0042428)2.65382374
143regulation of hippo signaling (GO:0035330)2.62595683
144pharyngeal system development (GO:0060037)2.62346905
145glycolytic process (GO:0006096)2.61976828
146peptidyl-glutamic acid modification (GO:0018200)2.61798305
147neuronal action potential (GO:0019228)2.60877574
148single strand break repair (GO:0000012)2.60794203
149positive regulation of cardiac muscle cell differentiation (GO:2000727)2.59747831
150regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.59727664
151glycerol metabolic process (GO:0006071)2.58451527
152tooth mineralization (GO:0034505)2.58423053
153response to pheromone (GO:0019236)2.56958851
154kidney morphogenesis (GO:0060993)2.56266879
155membrane depolarization during action potential (GO:0086010)2.56053340
156mitotic sister chromatid cohesion (GO:0007064)2.53739222
157pituitary gland development (GO:0021983)2.52915067
158photoreceptor cell development (GO:0042461)2.52756122
159limb development (GO:0060173)2.52299665
160appendage development (GO:0048736)2.52299665
161GTP biosynthetic process (GO:0006183)2.50005930
162primary amino compound metabolic process (GO:1901160)2.49970986
163mitochondrial respiratory chain complex assembly (GO:0033108)2.49853505
164establishment of protein localization to Golgi (GO:0072600)2.49549095
165cAMP catabolic process (GO:0006198)2.49100106
166calcium ion import (GO:0070509)2.48772346
167startle response (GO:0001964)2.48693088
168regulation of telomere maintenance (GO:0032204)2.47870429
169spinal cord development (GO:0021510)2.47665942
170N-acetylglucosamine metabolic process (GO:0006044)2.47652170
171embryonic hindlimb morphogenesis (GO:0035116)2.45873863
172dorsal/ventral axis specification (GO:0009950)2.45497000
173prostate gland growth (GO:0060736)2.44235464
174cardiovascular system development (GO:0072358)2.44044031
175regulation of mesoderm development (GO:2000380)2.43655395
176single-organism membrane fusion (GO:0044801)2.42660489
177peptidyl-threonine dephosphorylation (GO:0035970)2.26431165
178nuclear pore organization (GO:0006999)2.25196378
179fusion of sperm to egg plasma membrane (GO:0007342)15.5495231
180cilium or flagellum-dependent cell motility (GO:0001539)14.4790381
181cell wall macromolecule metabolic process (GO:0044036)13.1121657
182cell wall macromolecule catabolic process (GO:0016998)13.1121657
183multicellular organism reproduction (GO:0032504)12.7816775
184sperm motility (GO:0030317)12.3881246
185plasma membrane fusion (GO:0045026)11.8511658
186acrosome assembly (GO:0001675)11.7442836
187sperm-egg recognition (GO:0035036)11.6655787
188acrosome reaction (GO:0007340)10.8600346
189axonemal dynein complex assembly (GO:0070286)10.5835031
190cell-cell recognition (GO:0009988)10.4293817
191reproduction (GO:0000003)10.3819685
192epithelial cilium movement (GO:0003351)10.1091336

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.14701718
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.62644031
3EZH2_22144423_ChIP-Seq_EOC_Human4.18915317
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.73859326
5GBX2_23144817_ChIP-Seq_PC3_Human2.92299313
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.88747157
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67365477
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.55800593
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.39353772
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.27048071
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.26270493
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.20902041
13* FUS_26573619_Chip-Seq_HEK293_Human2.19973597
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16703858
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.16316564
16VDR_22108803_ChIP-Seq_LS180_Human2.10493101
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05649695
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.05457233
19EWS_26573619_Chip-Seq_HEK293_Human2.02376461
20ZNF274_21170338_ChIP-Seq_K562_Hela1.99614846
21KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.93848419
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89842736
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89799663
24KAP1_22055183_ChIP-Seq_ESCs_Mouse1.88873083
25TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.87125302
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.86672518
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86657572
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.86501696
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85583473
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82107648
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.78340137
32IGF1R_20145208_ChIP-Seq_DFB_Human1.75806775
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.75262778
34ELK4_26923725_Chip-Seq_MESODERM_Mouse1.74430513
35RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.70969530
36P300_19829295_ChIP-Seq_ESCs_Human1.70911617
37STAT1_17558387_ChIP-Seq_HELA_Human1.69757569
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69630960
39NFE2_27457419_Chip-Seq_LIVER_Mouse1.68883357
40KDM2B_26808549_Chip-Seq_REH_Human1.67964698
41TAL1_26923725_Chip-Seq_HPCs_Mouse1.67871844
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64832036
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.62617696
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.61845521
45MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61228262
46TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59181165
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.59177674
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.57062472
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55914601
50CBP_20019798_ChIP-Seq_JUKART_Human1.55914601
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.55838187
52IRF1_19129219_ChIP-ChIP_H3396_Human1.55072226
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50721625
54TP63_19390658_ChIP-ChIP_HaCaT_Human1.50190078
55STAT3_23295773_ChIP-Seq_U87_Human1.50133999
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49368319
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48394422
58* WDR5_24793694_ChIP-Seq_LNCAP_Human1.47742783
59* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47155691
60BCAT_22108803_ChIP-Seq_LS180_Human1.46106671
61CRX_20693478_ChIP-Seq_RETINA_Mouse1.41540474
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.41440557
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.41295227
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40615994
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.39953141
66TAF15_26573619_Chip-Seq_HEK293_Human1.39475837
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.38348717
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.35306881
69TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34898755
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33754126
71OCT4_18555785_Chip-Seq_ESCs_Mouse1.32664338
72SMAD4_21799915_ChIP-Seq_A2780_Human1.32176546
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31269719
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.30920208
75RNF2_27304074_Chip-Seq_NSC_Mouse1.30685757
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.30333285
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29832633
78P53_22387025_ChIP-Seq_ESCs_Mouse1.29642932
79AHR_22903824_ChIP-Seq_MCF-7_Human1.29621858
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29252750
81LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.28750153
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.28661093
83FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27883121
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.26961811
85EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25974079
86REST_21632747_ChIP-Seq_MESCs_Mouse1.25955311
87HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25732146
88DROSHA_22980978_ChIP-Seq_HELA_Human1.25483975
89P300_18555785_Chip-Seq_ESCs_Mouse1.24434129
90SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24211682
91GATA3_21867929_ChIP-Seq_CD8_Mouse1.24061373
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23908439
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.23296124
94GF1_26923725_Chip-Seq_HPCs_Mouse1.23291552
95SOX2_22085726_ChIP-Seq_NPCs_Mouse1.23267111
96OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23246362
97GATA3_21867929_ChIP-Seq_TH1_Mouse1.22402956
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.22099532
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20698682
100AR_25329375_ChIP-Seq_VCAP_Human1.20542430
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.20418141
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.20380466
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19644450
104RNF2_27304074_Chip-Seq_ESCs_Mouse1.18477654
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18315922
106SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17852884
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17390755
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16382095
109RUNX1_26923725_Chip-Seq_HPCs_Mouse1.15826892
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.15763733
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15693503
112AUTS2_25519132_ChIP-Seq_293T-REX_Human1.15360099
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.14817599
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.14727310
115SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13278460
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12939833
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12878094
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12878094
119* MYC_18940864_ChIP-ChIP_HL60_Human1.12837989
120* SMAD4_21741376_ChIP-Seq_EPCs_Human1.11099054
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.10639070
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.09266395
123LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07789422
124TP53_16413492_ChIP-PET_HCT116_Human1.07785842
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.06903585
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06773250
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05988821
128CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05882247
129AR_21572438_ChIP-Seq_LNCaP_Human1.05815100
130CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05676658
131P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05465322
132PU1_27457419_Chip-Seq_LIVER_Mouse1.04877425
133SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.04754493
134E2F1_18555785_Chip-Seq_ESCs_Mouse1.04463564
135RUNX2_22187159_ChIP-Seq_PCA_Human1.04451930
136P53_21459846_ChIP-Seq_SAOS-2_Human1.04446606
137TCF4_22108803_ChIP-Seq_LS180_Human1.04173154
138PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03548470
139RUNX1_27457419_Chip-Seq_LIVER_Mouse1.03306887
140GF1B_26923725_Chip-Seq_HPCs_Mouse1.01842596
141SMAD1_18555785_Chip-Seq_ESCs_Mouse1.01831528
142SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00065913
143SOX2_21211035_ChIP-Seq_LN229_Gbm0.99741034
144ZFX_18555785_Chip-Seq_ESCs_Mouse0.98475204
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98429723
146NMYC_18555785_Chip-Seq_ESCs_Mouse0.98351673
147SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98170917
148SMAD3_21741376_ChIP-Seq_ESCs_Human0.97663120
149ER_23166858_ChIP-Seq_MCF-7_Human0.97340837
150NFYB_21822215_ChIP-Seq_K562_Human0.97230706
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97078176
152EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96551291
153RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96551291
154SPI1_26923725_Chip-Seq_HPCs_Mouse0.95366369
155STAT3_18555785_ChIP-Seq_MESCs_Mouse0.95234308
156SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95198118
157* NCOR_22424771_ChIP-Seq_293T_Human0.95069615
158FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94824637
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94011368
160SOX9_26525672_Chip-Seq_HEART_Mouse0.93473920
161UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92202901
162RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91798707
163* TCF4_23295773_ChIP-Seq_U87_Human0.90804441
164TBL1_22424771_ChIP-Seq_293T_Human0.90799308
165SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.90673383
166NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89674480

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.02200905
2MP0001929_abnormal_gametogenesis5.36933170
3MP0008877_abnormal_DNA_methylation4.62508066
4MP0002653_abnormal_ependyma_morphology4.05020144
5MP0002210_abnormal_sex_determination3.58851393
6MP0006292_abnormal_olfactory_placode3.49171059
7MP0002161_abnormal_fertility/fecundity3.26405699
8MP0001145_abnormal_male_reproductive3.04122976
9MP0001485_abnormal_pinna_reflex2.83976248
10MP0000653_abnormal_sex_gland2.66388467
11MP0005623_abnormal_meninges_morphology2.63456239
12MP0005646_abnormal_pituitary_gland2.55102978
13MP0005670_abnormal_white_adipose2.31098945
14MP0003195_calcinosis2.19997314
15MP0000631_abnormal_neuroendocrine_gland2.15555455
16MP0004145_abnormal_muscle_electrophysio2.11740570
17MP0002138_abnormal_hepatobiliary_system2.09900731
18MP0004130_abnormal_muscle_cell2.00469288
19MP0005410_abnormal_fertilization15.3804670
20MP0000049_abnormal_middle_ear1.95764145
21MP0002282_abnormal_trachea_morphology1.91480934
22MP0002272_abnormal_nervous_system1.88159703
23MP0004142_abnormal_muscle_tone1.82212941
24MP0009046_muscle_twitch1.80762694
25MP0004885_abnormal_endolymph1.73629142
26MP0005174_abnormal_tail_pigmentation1.73229816
27MP0002876_abnormal_thyroid_physiology1.71881564
28MP0008872_abnormal_physiological_respon1.71221322
29MP0003646_muscle_fatigue1.54286011
30MP0009745_abnormal_behavioral_response1.53694580
31MP0002733_abnormal_thermal_nociception1.48761796
32MP0004233_abnormal_muscle_weight1.47939204
33MP0006072_abnormal_retinal_apoptosis1.46282373
34MP0002102_abnormal_ear_morphology1.42184313
35MP0002160_abnormal_reproductive_system1.39091899
36MP0002064_seizures1.33691044
37MP0002638_abnormal_pupillary_reflex1.32860021
38MP0002163_abnormal_gland_morphology1.30959358
39MP0008058_abnormal_DNA_repair1.26950655
40MP0002277_abnormal_respiratory_mucosa1.23023616
41MP0001970_abnormal_pain_threshold1.22755907
42MP0001486_abnormal_startle_reflex1.21658740
43MP0003119_abnormal_digestive_system1.19719968
44MP0002734_abnormal_mechanical_nocicepti1.18510986
45MP0003938_abnormal_ear_development1.15369008
46MP0000026_abnormal_inner_ear1.14260511
47MP0001765_abnormal_ion_homeostasis1.12306074
48MP0003937_abnormal_limbs/digits/tail_de1.09470168
49MP0008995_early_reproductive_senescence1.08120230
50MP0001188_hyperpigmentation1.08069923
51MP0001984_abnormal_olfaction1.07617431
52MP0002837_dystrophic_cardiac_calcinosis1.05993183
53MP0003635_abnormal_synaptic_transmissio1.04737463
54MP0003638_abnormal_response/metabolism_1.02314055
55MP0001502_abnormal_circadian_rhythm1.01302285
56MP0005647_abnormal_sex_gland1.01267696
57MP0000778_abnormal_nervous_system0.99077816
58MP0002063_abnormal_learning/memory/cond0.97725505
59MP0003724_increased_susceptibility_to0.95880771
60MP0009379_abnormal_foot_pigmentation0.95677237
61MP0005379_endocrine/exocrine_gland_phen0.95624258
62MP0003121_genomic_imprinting0.95307519
63MP0002234_abnormal_pharynx_morphology0.94675418
64MP0009384_cardiac_valve_regurgitation0.94059971
65MP0006276_abnormal_autonomic_nervous0.92208327
66MP0003136_yellow_coat_color0.91750837
67MP0008057_abnormal_DNA_replication0.91154023
68MP0002067_abnormal_sensory_capabilities0.90831249
69MP0001501_abnormal_sleep_pattern0.90082202
70MP0002184_abnormal_innervation0.89457012
71MP0000230_abnormal_systemic_arterial0.89247517
72MP0001919_abnormal_reproductive_system0.88422227
73MP0003880_abnormal_central_pattern0.88317063
74MP0005310_abnormal_salivary_gland0.87549369
75MP0010094_abnormal_chromosome_stability0.85884301
76MP0000383_abnormal_hair_follicle0.85147214
77MP0003011_delayed_dark_adaptation0.82630790
78MP0002938_white_spotting0.81735647
79MP0004924_abnormal_behavior0.81479804
80MP0005386_behavior/neurological_phenoty0.81479804
81MP0009765_abnormal_xenobiotic_induced0.81313983
82MP0005377_hearing/vestibular/ear_phenot0.81240935
83MP0003878_abnormal_ear_physiology0.81240935
84MP0009053_abnormal_anal_canal0.80554233
85MP0005423_abnormal_somatic_nervous0.79913114
86MP0001905_abnormal_dopamine_level0.79768541
87MP0002249_abnormal_larynx_morphology0.79595968
88MP0003936_abnormal_reproductive_system0.79226777
89MP0008789_abnormal_olfactory_epithelium0.78936406
90MP0000613_abnormal_salivary_gland0.78867399
91MP0000015_abnormal_ear_pigmentation0.78373274
92MP0001529_abnormal_vocalization0.76492936
93MP0001293_anophthalmia0.72325876
94MP0000569_abnormal_digit_pigmentation0.69675159
95MP0005389_reproductive_system_phenotype0.66068257
96MP0002928_abnormal_bile_duct0.63618906
97MP0003950_abnormal_plasma_membrane0.59953637
98MP0003115_abnormal_respiratory_system0.59750587
99MP0003786_premature_aging0.58261009
100MP0003699_abnormal_female_reproductive0.56040838
101MP0005636_abnormal_mineral_homeostasis0.52397343
102MP0003111_abnormal_nucleus_morphology0.52160554
103MP0005551_abnormal_eye_electrophysiolog0.50913827
104MP0004036_abnormal_muscle_relaxation0.49695685
105MP0001119_abnormal_female_reproductive0.49161507
106MP0005666_abnormal_adipose_tissue0.46229615
107MP0001324_abnormal_eye_pigmentation0.44977839
108MP0002971_abnormal_brown_adipose0.43044782
109MP0000358_abnormal_cell_content/0.41527458
110MP0008007_abnormal_cellular_replicative0.39759710
111MP0005253_abnormal_eye_physiology0.38528682
112MP0005391_vision/eye_phenotype0.38070985
113MP0010307_abnormal_tumor_latency0.36518424
114MP0004019_abnormal_vitamin_homeostasis0.36136519
115MP0003861_abnormal_nervous_system0.35505890
116MP0002269_muscular_atrophy0.35263810
117MP0009115_abnormal_fat_cell0.34648790
118MP0003283_abnormal_digestive_organ0.30937369
119MP0004742_abnormal_vestibular_system0.30495454
120MP0002152_abnormal_brain_morphology0.29914866
121MP0001764_abnormal_homeostasis0.29456105
122MP0000432_abnormal_head_morphology0.29007115
123MP0003633_abnormal_nervous_system0.28511879
124MP0002092_abnormal_eye_morphology0.27676908
125MP0000427_abnormal_hair_cycle0.26548397
126MP0003045_fibrosis0.26546928
127MP0002736_abnormal_nociception_after0.26333636
128MP0003879_abnormal_hair_cell0.25029745
129MP0005503_abnormal_tendon_morphology0.24476371
130MP0001968_abnormal_touch/_nociception0.24234761
131MP0004133_heterotaxia0.23862309
132MP0004134_abnormal_chest_morphology0.23449211
133MP0009250_abnormal_appendicular_skeleto0.23005501
134MP0005397_hematopoietic_system_phenotyp0.22232193
135MP0001545_abnormal_hematopoietic_system0.22232193
136MP0004811_abnormal_neuron_physiology0.22177583
137MP0008961_abnormal_basal_metabolism0.22101199
138MP0004808_abnormal_hematopoietic_stem0.21069135
139MP0001440_abnormal_grooming_behavior0.20661411
140MP0002572_abnormal_emotion/affect_behav0.20341838
141MP0003631_nervous_system_phenotype0.19736870
142MP0002139_abnormal_hepatobiliary_system0.19004661
143MP0002735_abnormal_chemical_nociception0.18673029
144MP0002084_abnormal_developmental_patter0.18667798
145MP0005195_abnormal_posterior_eye0.18260269
146MP0003890_abnormal_embryonic-extraembry0.17776704
147MP0001270_distended_abdomen0.17726056
148MP0003942_abnormal_urinary_system0.17563220
149MP0005535_abnormal_body_temperature0.17558425
150MP0002557_abnormal_social/conspecific_i0.17510121
151MP0000647_abnormal_sebaceous_gland0.17173756
152MP0009278_abnormal_bone_marrow0.16979765
153MP0000955_abnormal_spinal_cord0.16687083
154MP0006138_congestive_heart_failure0.16621882
155MP0002108_abnormal_muscle_morphology0.15948160
156MP0002109_abnormal_limb_morphology0.15878689
157MP0001963_abnormal_hearing_physiology0.15862127
158MP0005388_respiratory_system_phenotype0.15058509
159MP0002133_abnormal_respiratory_system0.15058509
160MP0002752_abnormal_somatic_nervous0.14882619
161MP0003948_abnormal_gas_homeostasis0.13861299
162MP0003787_abnormal_imprinting0.13837067
163MP0001851_eye_inflammation0.13638805
164MP0001986_abnormal_taste_sensitivity0.13479242

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.31079592
2Abnormal respiratory motile cilium morphology (HP:0005938)8.99593242
3Abnormal respiratory epithelium morphology (HP:0012253)8.99593242
4Rhinitis (HP:0012384)7.74300950
5Abnormal ciliary motility (HP:0012262)7.67830024
6Chronic bronchitis (HP:0004469)6.85197214
7Nasal polyposis (HP:0100582)6.19901817
8Infertility (HP:0000789)6.01391250
9Abnormality of the nasal mucosa (HP:0000433)5.06181087
10Genetic anticipation (HP:0003743)4.85915796
11Bronchiectasis (HP:0002110)4.56593389
12Bronchitis (HP:0012387)4.55327797
13Pendular nystagmus (HP:0012043)4.27531088
14Pancreatic cysts (HP:0001737)4.20544894
15Nephronophthisis (HP:0000090)4.13331563
16Progressive cerebellar ataxia (HP:0002073)4.09741178
17Male infertility (HP:0003251)3.99638688
18Recurrent sinusitis (HP:0011108)3.59473580
19Absent rod-and cone-mediated responses on ERG (HP:0007688)3.58457774
20Abolished electroretinogram (ERG) (HP:0000550)3.51917418
21Abnormal spermatogenesis (HP:0008669)3.39291877
22Recurrent otitis media (HP:0000403)3.35220630
23Severe visual impairment (HP:0001141)3.32849304
24Agitation (HP:0000713)3.18819886
25Abnormality of the renal medulla (HP:0100957)3.18470883
26Abnormal rod and cone electroretinograms (HP:0008323)3.08102448
27Abnormality of DNA repair (HP:0003254)3.05269030
28Recurrent bronchitis (HP:0002837)3.02081519
29Methylmalonic acidemia (HP:0002912)3.00370454
30Medial flaring of the eyebrow (HP:0010747)2.95717352
31Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.92254340
32Short 1st metacarpal (HP:0010034)2.92254340
33Congenital stationary night blindness (HP:0007642)2.87103724
34Increased corneal curvature (HP:0100692)2.85611951
35Keratoconus (HP:0000563)2.85611951
36Congenital sensorineural hearing impairment (HP:0008527)2.81344450
37Asplenia (HP:0001746)2.78483285
38Impulsivity (HP:0100710)2.74162952
39Attenuation of retinal blood vessels (HP:0007843)2.71506171
40Homocystinuria (HP:0002156)2.70962074
41Abnormality of homocysteine metabolism (HP:0010919)2.70962074
42Aplasia/Hypoplasia of the spleen (HP:0010451)2.68632476
43Tubulointerstitial nephritis (HP:0001970)2.68598806
44Abnormality of the nasal septum (HP:0000419)2.67060667
45Furrowed tongue (HP:0000221)2.66498853
46Confusion (HP:0001289)2.63136895
47Porencephaly (HP:0002132)2.60684960
48Abnormality of the renal collecting system (HP:0004742)2.57030956
49Methylmalonic aciduria (HP:0012120)2.50373088
50Abnormality of the 1st metacarpal (HP:0010009)2.49529728
51Abnormality of midbrain morphology (HP:0002418)2.46405030
52Molar tooth sign on MRI (HP:0002419)2.46405030
53Absent thumb (HP:0009777)2.43937333
54Azoospermia (HP:0000027)2.42961375
55Type II lissencephaly (HP:0007260)2.40184419
56Septo-optic dysplasia (HP:0100842)2.36808593
57Gaze-evoked nystagmus (HP:0000640)2.33145913
58Gonadotropin excess (HP:0000837)2.32725018
59Tubular atrophy (HP:0000092)2.31534545
60Anencephaly (HP:0002323)2.26964185
61Chorioretinal atrophy (HP:0000533)2.25167324
62Bony spicule pigmentary retinopathy (HP:0007737)2.22494816
63Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.19245759
64Conjunctival hamartoma (HP:0100780)2.18747136
65Hamartoma of the eye (HP:0010568)2.18375088
66Tubulointerstitial abnormality (HP:0001969)2.17887832
67Visual hallucinations (HP:0002367)2.17364030
68Hemiplegia (HP:0002301)2.16601870
693-Methylglutaconic aciduria (HP:0003535)2.15522148
70Aplasia/Hypoplasia of the hallux (HP:0008362)2.09166143
71Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08990286
72Ectopic kidney (HP:0000086)2.08526797
73Sclerocornea (HP:0000647)2.08267795
74Optic nerve hypoplasia (HP:0000609)2.08255160
75Male pseudohermaphroditism (HP:0000037)2.08227872
76Short hallux (HP:0010109)2.08190505
77Short phalanx of the thumb (HP:0009660)2.08140377
78Gait imbalance (HP:0002141)2.07547612
79Congenital primary aphakia (HP:0007707)2.07346467
80Postaxial foot polydactyly (HP:0001830)2.05360631
81Congenital, generalized hypertrichosis (HP:0004540)2.03505553
82Absent frontal sinuses (HP:0002688)2.02090956
83Duplicated collecting system (HP:0000081)2.02074913
84Hypoplastic pelvis (HP:0008839)2.01481680
85Aplasia/Hypoplasia of the uvula (HP:0010293)2.01440220
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7620834
87Dynein arm defect of respiratory motile cilia (HP:0012255)12.9378090
88Absent/shortened dynein arms (HP:0200106)12.9378090
89Small hand (HP:0200055)1.99410174
90Abnormality of the proximal phalanges of the hand (HP:0009834)1.99084067
91Truncal obesity (HP:0001956)1.97117705
92Clumsiness (HP:0002312)1.96990537
93Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95176691
94Microglossia (HP:0000171)1.93041646
95Short ribs (HP:0000773)1.92458571
96Hyperventilation (HP:0002883)1.92048537
97Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89613426
98Spastic tetraparesis (HP:0001285)1.89556149
99Aplasia/Hypoplasia of the tibia (HP:0005772)1.88647086
100Chronic sinusitis (HP:0011109)1.88103386
101Fibular hypoplasia (HP:0003038)1.88008726
102Morphological abnormality of the middle ear (HP:0008609)1.87428105
103Impaired smooth pursuit (HP:0007772)1.87055495
104Congenital hepatic fibrosis (HP:0002612)1.86451297
105Abnormality of chromosome stability (HP:0003220)1.85686889
106Heterotopia (HP:0002282)1.84727335
107Renal cortical cysts (HP:0000803)1.84502222
108Carpal bone hypoplasia (HP:0001498)1.83339053
109Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83333816
110Short 4th metacarpal (HP:0010044)1.83321046
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83321046
112Abnormality of the phalanges of the 5th finger (HP:0004213)1.82261438
113Abnormality of the vitamin B12 metabolism (HP:0004341)1.80087255
114Abnormality of the middle phalanges of the toes (HP:0010183)1.79311371
115Broad-based gait (HP:0002136)1.78721980
116Nephrogenic diabetes insipidus (HP:0009806)1.77548402
117Intellectual disability, moderate (HP:0002342)1.75609474
118Inability to walk (HP:0002540)1.75580341
119Facial cleft (HP:0002006)1.75366805
120Abnormality of binocular vision (HP:0011514)1.75239416
121Diplopia (HP:0000651)1.75239416
122Abnormality of dentin (HP:0010299)1.74050828
123Synostosis of carpal bones (HP:0005048)1.73490796
124Abnormality of vitamin B metabolism (HP:0004340)1.73326316
125Goiter (HP:0000853)1.72274530
126Abnormality of the lower motor neuron (HP:0002366)1.71755289
127Stenosis of the external auditory canal (HP:0000402)1.71180728
128Decreased central vision (HP:0007663)1.70707047
129Postaxial hand polydactyly (HP:0001162)1.68543734
130Stage 5 chronic kidney disease (HP:0003774)1.68411814
131Abnormality of the renal cortex (HP:0011035)1.65037036
132Tubulointerstitial fibrosis (HP:0005576)1.64666518
133Absent epiphyses (HP:0010577)1.64112412
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64112412
135Tongue fasciculations (HP:0001308)1.63780554
136Genital tract atresia (HP:0001827)1.62890153
137Cholecystitis (HP:0001082)1.62739467
138Abnormal gallbladder physiology (HP:0012438)1.62739467
139Pancreatic fibrosis (HP:0100732)1.62092470
140Renal dysplasia (HP:0000110)1.59927818
141Poor coordination (HP:0002370)1.58779026
142Aplasia/Hypoplasia of the lens (HP:0008063)1.58570126
143Vaginal atresia (HP:0000148)1.58496318
144Abnormality of the dental pulp (HP:0006479)1.57677231
145Dyschromatopsia (HP:0007641)1.56478568
146Bell-shaped thorax (HP:0001591)1.56168889
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.53574191
148J-shaped sella turcica (HP:0002680)1.52952990
149Muscle fibrillation (HP:0010546)1.51600119
150Abnormality of permanent molar morphology (HP:0011071)1.49906691
151Abnormality of the dental root (HP:0006486)1.49906691
152Taurodontia (HP:0000679)1.49906691
153Abnormal biliary tract physiology (HP:0012439)1.46390447
154Bile duct proliferation (HP:0001408)1.46390447
155Supernumerary spleens (HP:0009799)1.45497482
156Abnormality of molar morphology (HP:0011070)1.43520067
157Abnormality of molar (HP:0011077)1.43520067
158Polydipsia (HP:0001959)1.42941130
159Abnormal drinking behavior (HP:0030082)1.42941130
160Oculomotor apraxia (HP:0000657)1.41924944
161Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.38872297
162Abnormality of saccadic eye movements (HP:0000570)1.38858871
163Median cleft lip (HP:0000161)1.38753388
164Cystic liver disease (HP:0006706)1.37989619
165Amyotrophic lateral sclerosis (HP:0007354)1.37468055
166Abnormality of renal excretion (HP:0011036)1.35596927
167Abnormality of ocular smooth pursuit (HP:0000617)1.35101311
168Nephroblastoma (Wilms tumor) (HP:0002667)1.33395784
169Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.31675115
170Short thorax (HP:0010306)1.30528185
171Deformed sella turcica (HP:0002681)1.28052490
172Impaired proprioception (HP:0010831)1.26813915
173Hemiparesis (HP:0001269)1.24960179
174Embryonal renal neoplasm (HP:0011794)1.22676157
175Cerebellar dysplasia (HP:0007033)1.22564096
176Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.22417090
177True hermaphroditism (HP:0010459)1.21768749
178Pachygyria (HP:0001302)1.21333283
179Short femoral neck (HP:0100864)1.19352851
180Chronic hepatic failure (HP:0100626)1.17818499
181Astigmatism (HP:0000483)1.17337494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.44947782
2PDK48.44947782
3PDK25.52700822
4TESK14.81187692
5PRKD34.61077847
6FRK4.20756067
7ICK3.54007069
8GRK13.49629186
9MAP4K23.38035277
10ADRBK23.32433343
11PNCK2.96668211
12TAOK32.93055513
13WNK42.65045161
14PRKD22.50949713
15STK392.41265425
16PTK2B2.33341742
17TLK11.91370607
18ZAK1.77803029
19INSRR1.73109969
20TXK1.71122347
21NEK21.55807333
22STK381.55160597
23ACVR1B1.47669407
24TNIK1.38635431
25MAPK131.35391047
26BLK1.31329813
27GRK61.28438525
28MAP3K91.26874665
29DYRK1B1.26802926
30CASK1.23031769
31DYRK21.18441545
32TIE11.17687569
33TAF11.16388728
34WNK11.14473014
35PDK11.00894450
36CAMK1G0.99549821
37WEE10.98746696
38DAPK20.98280555
39CCNB10.92244785
40IKBKB0.89563923
41FGFR20.89391767
42TYRO30.88476780
43PLK40.87658642
44LMTK20.87552869
45VRK10.85127874
46CDK120.84193534
47SGK20.82751549
48PAK30.80942116
49ERBB20.79730117
50DYRK30.79459898
51CHEK20.79090380
52STK30.78422780
53SGK4940.77220814
54SGK2230.77220814
55NLK0.76677034
56SYK0.76458877
57OXSR10.76458575
58MAPK150.76287874
59ADRBK10.76184041
60CSNK1A1L0.73962102
61PRKCH0.73313240
62PLK20.73286046
63TEC0.72622397
64CSNK1G20.71917032
65RPS6KA60.71339963
66BRSK20.70914799
67TTK0.69090133
68STK38L0.68518800
69CAMKK20.68070585
70CSNK1G30.65950394
71CAMK1D0.65830182
72CSNK1G10.64683198
73CSNK1A10.63331942
74PIK3CA0.62564589
75GRK70.61476012
76RPS6KA50.59630310
77NEK60.59609401
78MAP4K10.59357174
79MAP2K20.58972373
80CHEK10.55941466
81IRAK10.55808872
82OBSCN0.55381134
83KIT0.54060647
84PRKCE0.53527956
85BTK0.53523032
86PASK0.52863856
87SGK10.50488469
88MAP2K40.50347673
89CHUK0.49737167
90FLT30.49265573
91CDC70.48830852
92PDPK10.48687789
93TESK20.47858835
94FES0.47801859
95GRK50.47132557
96CAMK40.45988786
97MKNK20.45301733
98MAP2K60.44950530
99MELK0.44503026
100RPS6KA20.43975765
101MAPKAPK30.43434146
102ITK0.43394017
103CDK90.43030109
104LYN0.42984968
105RIPK40.42570910
106ATR0.39122940
107ATM0.38746101
108RIPK10.33314755
109PLK10.32857759
110PAK10.31931193
111BUB10.31027781
112BRSK10.30331442
113BMPR1B0.30300975
114MUSK0.29069859
115PKN10.28387928
116MAP2K70.28216726
117MTOR0.27626742
118LATS10.27025118
119NTRK20.26590353
120PRKCG0.26017220
121STK160.25971096
122EEF2K0.24563345
123MARK30.24216534
124PAK20.23879534
125PRKAA10.22215237
126WNK30.21513391
127MAP3K40.19500761
128CAMKK10.17742934
129YES10.17714511
130CSNK1D0.14087517
131PINK10.13785685
132PRKCQ0.12075620
133RPS6KB10.11545504
134STK110.11413998
135PRKG10.10938650
136CDK10.10418665
137MARK20.10418569
138GSK3B0.10099402
139CSNK2A20.09588307
140CSNK2A10.09284554
141AKT30.08444812
142CDK30.07778359
143CDK40.07675835
144PDGFRB0.07668551
145CDK20.07665039
146PRKDC0.06341936
147CAMK2A0.06285272
148EGFR0.05867636
149PRKCB0.05293754
150MAPKAPK50.04952887
151PRKCZ0.04919653
152PRKACG0.04312892
153PRKG20.04176110
154CDK60.03453053
155CAMK10.03060987
156PAK40.02556173
157CDK150.01948633
158MAPK80.01803544
159EPHB20.01403797
160IRAK20.01346310
161ZAP700.00919580
162MARK10.00202153
163MAPK1-0.0076144
164CDK18-0.0056279
165NUAK1-0.0053886
166RPS6KA1-0.0028655
167PRKACA-0.0027715

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.10135144
2Vitamin B6 metabolism_Homo sapiens_hsa007503.90911414
3Fatty acid biosynthesis_Homo sapiens_hsa000613.62812520
4Pyruvate metabolism_Homo sapiens_hsa006203.50417690
5Propanoate metabolism_Homo sapiens_hsa006403.08314387
6Phototransduction_Homo sapiens_hsa047442.83776736
7Basal transcription factors_Homo sapiens_hsa030222.83588891
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.82784816
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.58626933
10Nicotine addiction_Homo sapiens_hsa050332.56112476
11Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.52399892
12Glucagon signaling pathway_Homo sapiens_hsa049222.51362835
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49918043
14Linoleic acid metabolism_Homo sapiens_hsa005912.43300347
15Fanconi anemia pathway_Homo sapiens_hsa034602.42604641
16Pentose phosphate pathway_Homo sapiens_hsa000302.35257709
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28638811
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.24708317
19Dorso-ventral axis formation_Homo sapiens_hsa043202.21630468
20Selenocompound metabolism_Homo sapiens_hsa004502.16268566
21Oocyte meiosis_Homo sapiens_hsa041142.13460551
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.03836637
23Glycosaminoglycan degradation_Homo sapiens_hsa005312.03654174
24Glycerolipid metabolism_Homo sapiens_hsa005612.02596438
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.02477729
26Nitrogen metabolism_Homo sapiens_hsa009101.99331746
27Carbohydrate digestion and absorption_Homo sapiens_hsa049731.99209764
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.90739941
29PPAR signaling pathway_Homo sapiens_hsa033201.79737079
30Morphine addiction_Homo sapiens_hsa050321.72922225
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.70615771
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.69817388
33Huntingtons disease_Homo sapiens_hsa050161.69364588
34Primary immunodeficiency_Homo sapiens_hsa053401.49561213
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.46943887
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.40437430
37Melanoma_Homo sapiens_hsa052181.40236700
38Mineral absorption_Homo sapiens_hsa049781.40133986
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37477596
40RNA polymerase_Homo sapiens_hsa030201.33145029
41Amphetamine addiction_Homo sapiens_hsa050311.33005143
42Tryptophan metabolism_Homo sapiens_hsa003801.31181270
43Glutamatergic synapse_Homo sapiens_hsa047241.31071914
44Carbon metabolism_Homo sapiens_hsa012001.30664133
45Fructose and mannose metabolism_Homo sapiens_hsa000511.26805897
46RNA transport_Homo sapiens_hsa030131.25328621
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.24228178
48Basal cell carcinoma_Homo sapiens_hsa052171.23874706
49Renin-angiotensin system_Homo sapiens_hsa046141.21161464
50Asthma_Homo sapiens_hsa053101.19209191
51mRNA surveillance pathway_Homo sapiens_hsa030151.17980478
52Renin secretion_Homo sapiens_hsa049241.17090949
53Serotonergic synapse_Homo sapiens_hsa047261.15844952
54Cardiac muscle contraction_Homo sapiens_hsa042601.15673554
55Oxidative phosphorylation_Homo sapiens_hsa001901.13737750
56RNA degradation_Homo sapiens_hsa030181.09947681
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09448951
58Ether lipid metabolism_Homo sapiens_hsa005651.07178703
59Sulfur metabolism_Homo sapiens_hsa009201.06846788
60Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.06409794
61Antigen processing and presentation_Homo sapiens_hsa046121.05477450
62Type II diabetes mellitus_Homo sapiens_hsa049301.05249441
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03378802
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.02528320
65Purine metabolism_Homo sapiens_hsa002301.01914254
66Fatty acid metabolism_Homo sapiens_hsa012121.01283394
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98422158
68Fat digestion and absorption_Homo sapiens_hsa049750.97601481
69Fatty acid degradation_Homo sapiens_hsa000710.95945074
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92946115
71Biosynthesis of amino acids_Homo sapiens_hsa012300.91011748
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88847963
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88707135
74GABAergic synapse_Homo sapiens_hsa047270.88697902
75Taste transduction_Homo sapiens_hsa047420.85164643
76MAPK signaling pathway_Homo sapiens_hsa040100.84574938
77Ribosome_Homo sapiens_hsa030100.84559262
78Protein digestion and absorption_Homo sapiens_hsa049740.81838456
79Cholinergic synapse_Homo sapiens_hsa047250.80902909
80Calcium signaling pathway_Homo sapiens_hsa040200.79202520
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76763286
82Insulin secretion_Homo sapiens_hsa049110.76513719
83Caffeine metabolism_Homo sapiens_hsa002320.75831871
84Regulation of autophagy_Homo sapiens_hsa041400.75302909
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74951696
86ABC transporters_Homo sapiens_hsa020100.74276090
87Estrogen signaling pathway_Homo sapiens_hsa049150.72283391
88Parkinsons disease_Homo sapiens_hsa050120.72036171
89N-Glycan biosynthesis_Homo sapiens_hsa005100.71879369
90Long-term depression_Homo sapiens_hsa047300.71254951
91Circadian rhythm_Homo sapiens_hsa047100.70625315
92Inositol phosphate metabolism_Homo sapiens_hsa005620.70049479
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69176819
94Hedgehog signaling pathway_Homo sapiens_hsa043400.67588485
95Collecting duct acid secretion_Homo sapiens_hsa049660.66815128
96Butanoate metabolism_Homo sapiens_hsa006500.66061307
97Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.65392496
98Ras signaling pathway_Homo sapiens_hsa040140.64378916
99Alzheimers disease_Homo sapiens_hsa050100.63941243
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63207634
101Graft-versus-host disease_Homo sapiens_hsa053320.62249812
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61383299
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61380158
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.60847325
105Bile secretion_Homo sapiens_hsa049760.60471255
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60029196
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59730574
108Type I diabetes mellitus_Homo sapiens_hsa049400.59474112
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58186453
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57480225
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.55823319
112Dopaminergic synapse_Homo sapiens_hsa047280.55719460
113Oxytocin signaling pathway_Homo sapiens_hsa049210.55130159
114Synaptic vesicle cycle_Homo sapiens_hsa047210.54225257
115Long-term potentiation_Homo sapiens_hsa047200.54053763
116Thyroid hormone synthesis_Homo sapiens_hsa049180.53700328
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53417802
118Autoimmune thyroid disease_Homo sapiens_hsa053200.52740547
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51807579
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51439380
121Arachidonic acid metabolism_Homo sapiens_hsa005900.49531667
122T cell receptor signaling pathway_Homo sapiens_hsa046600.49256886
123Glutathione metabolism_Homo sapiens_hsa004800.47520807
124Allograft rejection_Homo sapiens_hsa053300.47490255
125Hematopoietic cell lineage_Homo sapiens_hsa046400.46827513
126Nucleotide excision repair_Homo sapiens_hsa034200.46365786
127Wnt signaling pathway_Homo sapiens_hsa043100.46244445
128Axon guidance_Homo sapiens_hsa043600.45768991
129Salivary secretion_Homo sapiens_hsa049700.45093937
130Peroxisome_Homo sapiens_hsa041460.44133119
131Chemical carcinogenesis_Homo sapiens_hsa052040.43931868
132Rap1 signaling pathway_Homo sapiens_hsa040150.42852567
133Steroid hormone biosynthesis_Homo sapiens_hsa001400.42511682
134Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41734731
135Metabolic pathways_Homo sapiens_hsa011000.40734388
136Circadian entrainment_Homo sapiens_hsa047130.38488864
137AMPK signaling pathway_Homo sapiens_hsa041520.37389086
138Cell cycle_Homo sapiens_hsa041100.36653811
139Legionellosis_Homo sapiens_hsa051340.35601348
140Pancreatic secretion_Homo sapiens_hsa049720.34983038
141Endocytosis_Homo sapiens_hsa041440.34680824
142Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34264009
143cAMP signaling pathway_Homo sapiens_hsa040240.33917975
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33546229
145Gastric acid secretion_Homo sapiens_hsa049710.31295730
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31035325
147Homologous recombination_Homo sapiens_hsa034400.31022048
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.30871950
149Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.27355483
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.25495941
151Vitamin digestion and absorption_Homo sapiens_hsa049770.23065910
152Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21597565
153Retinol metabolism_Homo sapiens_hsa008300.20370902
154Ovarian steroidogenesis_Homo sapiens_hsa049130.19042008
155Pyrimidine metabolism_Homo sapiens_hsa002400.16334169
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16244544
157Systemic lupus erythematosus_Homo sapiens_hsa053220.15991742
158Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14973767
159Olfactory transduction_Homo sapiens_hsa047400.14514853
160Lysine degradation_Homo sapiens_hsa003100.13769719
161Cocaine addiction_Homo sapiens_hsa050300.13453424
162Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.13248438
163Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12488871

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