LRRC32

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of extracellular ligand from receptor (GO:0035581)5.70248927
2wound healing, spreading of epidermal cells (GO:0035313)5.62155175
3collagen fibril organization (GO:0030199)5.61238325
4chondrocyte proliferation (GO:0035988)5.57382079
5positive regulation of endothelial cell apoptotic process (GO:2000353)5.29123341
6protein heterotrimerization (GO:0070208)5.03043907
7wound healing, spreading of cells (GO:0044319)4.75536405
8vascular endothelial growth factor signaling pathway (GO:0038084)4.66943855
9cell adhesion mediated by integrin (GO:0033627)4.66181620
10skin morphogenesis (GO:0043589)4.51761606
11retina vasculature morphogenesis in camera-type eye (GO:0061299)4.44408490
12endothelium development (GO:0003158)4.37445512
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.32010458
14endodermal cell differentiation (GO:0035987)4.26098848
15lymphangiogenesis (GO:0001946)4.24963087
16fibril organization (GO:0097435)4.22209742
17negative regulation of fibrinolysis (GO:0051918)4.17745454
18regulation of tight junction assembly (GO:2000810)4.01231464
19extracellular fibril organization (GO:0043206)3.96557271
20dermatan sulfate biosynthetic process (GO:0030208)3.96409377
21extracellular matrix assembly (GO:0085029)3.96284963
22negative regulation of platelet activation (GO:0010544)3.86132645
23adhesion of symbiont to host cell (GO:0044650)3.83006883
24virion attachment to host cell (GO:0019062)3.83006883
25basement membrane organization (GO:0071711)3.76904816
26endothelial cell morphogenesis (GO:0001886)3.73750131
27apoptotic cell clearance (GO:0043277)3.72893394
28bone trabecula formation (GO:0060346)3.71413723
29negative regulation of fatty acid transport (GO:2000192)3.67537569
30peptidyl-proline hydroxylation (GO:0019511)3.66047127
31regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.65730678
32regulation of plasminogen activation (GO:0010755)3.65282954
33adhesion of symbiont to host (GO:0044406)3.64796836
34dermatan sulfate metabolic process (GO:0030205)3.64375154
35type B pancreatic cell proliferation (GO:0044342)3.63168369
36negative regulation of homotypic cell-cell adhesion (GO:0034111)3.62049792
37angiogenesis involved in wound healing (GO:0060055)3.54581654
38positive regulation of receptor recycling (GO:0001921)3.53960028
39collagen metabolic process (GO:0032963)3.52551937
40positive regulation of blood vessel endothelial cell migration (GO:0043536)3.51291548
41cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.45618016
42regulation of integrin-mediated signaling pathway (GO:2001044)3.37891223
43collagen catabolic process (GO:0030574)3.37623339
44cell migration involved in heart development (GO:0060973)3.35930228
45peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.34341202
46endothelial cell proliferation (GO:0001935)3.32341759
47mesenchymal-epithelial cell signaling (GO:0060638)3.29240484
48negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.28712481
49multicellular organismal macromolecule metabolic process (GO:0044259)3.27760925
50neuron projection extension involved in neuron projection guidance (GO:1902284)3.25825351
51axon extension involved in axon guidance (GO:0048846)3.25825351
52cellular response to vitamin (GO:0071295)3.24460057
53positive regulation of hemostasis (GO:1900048)3.24459609
54positive regulation of blood coagulation (GO:0030194)3.24459609
55cell migration involved in sprouting angiogenesis (GO:0002042)3.24263789
56epoxygenase P450 pathway (GO:0019373)3.23508864
57lymph vessel development (GO:0001945)3.22136271
58cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.19492362
59cellular response to interferon-alpha (GO:0035457)3.17724562
60extracellular matrix disassembly (GO:0022617)3.16516795
61positive regulation of natural killer cell differentiation (GO:0032825)3.13247977
62positive regulation of epithelial to mesenchymal transition (GO:0010718)3.12682426
63platelet degranulation (GO:0002576)3.11096178
64multicellular organismal catabolic process (GO:0044243)3.09958872
65multicellular organismal metabolic process (GO:0044236)3.09095227
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09053270
67protein retention in ER lumen (GO:0006621)3.08393768
68regulation of endothelial cell apoptotic process (GO:2000351)3.06407628
69regulation of monocyte chemotaxis (GO:0090025)3.02197279
70positive regulation of macrophage activation (GO:0043032)3.00556307
71substrate-dependent cell migration (GO:0006929)3.00342800
72extracellular regulation of signal transduction (GO:1900115)2.99492686
73extracellular negative regulation of signal transduction (GO:1900116)2.99492686
74positive regulation of coagulation (GO:0050820)2.98996379
75regulation of fibrinolysis (GO:0051917)2.98810815
76positive regulation of endothelial cell differentiation (GO:0045603)2.96517823
77keratan sulfate catabolic process (GO:0042340)2.95316048
78extracellular matrix organization (GO:0030198)2.94498254
79negative regulation of smooth muscle cell migration (GO:0014912)2.93846938
80extracellular structure organization (GO:0043062)2.92999183
81cellular response to vitamin D (GO:0071305)2.92748677
82positive regulation of endothelial cell migration (GO:0010595)2.92610023
83response to laminar fluid shear stress (GO:0034616)2.90844928
84regulation of metalloenzyme activity (GO:0048552)2.90215652
85protein hydroxylation (GO:0018126)2.88157245
86regulation of platelet activation (GO:0010543)2.87088789
87blood vessel maturation (GO:0001955)2.86931037
88response to fluid shear stress (GO:0034405)2.86689622
89omega-hydroxylase P450 pathway (GO:0097267)2.86073374
90positive regulation of astrocyte differentiation (GO:0048711)2.82978748
91blood vessel endothelial cell migration (GO:0043534)2.82934124
92stress fiber assembly (GO:0043149)2.82751408
93negative regulation of adherens junction organization (GO:1903392)2.81619646
94negative regulation of focal adhesion assembly (GO:0051895)2.81619646
95negative regulation of cell junction assembly (GO:1901889)2.81619646
96epithelial cell-cell adhesion (GO:0090136)2.81476240
97barbed-end actin filament capping (GO:0051016)2.80582514
98craniofacial suture morphogenesis (GO:0097094)2.80301253
99vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.80166560
100protein localization to cell surface (GO:0034394)2.80105398
101protein targeting to plasma membrane (GO:0072661)2.77916905
102negative regulation of blood vessel endothelial cell migration (GO:0043537)2.77428009
103regulation of endothelial cell differentiation (GO:0045601)2.77377738
104wound healing (GO:0042060)2.76137074
105positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.75719915
106regulation of platelet aggregation (GO:0090330)2.74240325
107positive regulation of extracellular matrix organization (GO:1903055)2.72057067
108substrate adhesion-dependent cell spreading (GO:0034446)2.71532232
109negative regulation of protein localization to cell surface (GO:2000009)2.69882121
110sprouting angiogenesis (GO:0002040)2.69056811
111membrane raft organization (GO:0031579)2.68589299
112chondroitin sulfate biosynthetic process (GO:0030206)2.68164324
113positive regulation of collagen biosynthetic process (GO:0032967)2.67641598
114cell proliferation involved in metanephros development (GO:0072203)2.67335124
115glomerular filtration (GO:0003094)2.64676388
116venous blood vessel morphogenesis (GO:0048845)2.59534309
117negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.56563281
118surfactant homeostasis (GO:0043129)2.48276835
119positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.46366226
120glomerular basement membrane development (GO:0032836)2.45928853
121renal filtration (GO:0097205)2.43037295
122positive regulation of Rho protein signal transduction (GO:0035025)2.42711043
123cell-substrate junction assembly (GO:0007044)2.41946767
124regulation of membrane protein ectodomain proteolysis (GO:0051043)2.41590645
125positive regulation of fibroblast migration (GO:0010763)2.41354939
126regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.41266557
127platelet aggregation (GO:0070527)2.40948279
128positive regulation of protein kinase C signaling (GO:0090037)2.33165490
129hyaluronan catabolic process (GO:0030214)2.33043555
130atrioventricular valve morphogenesis (GO:0003181)2.32599094
131blood coagulation, intrinsic pathway (GO:0007597)2.32157582
132thrombin receptor signaling pathway (GO:0070493)2.31993681
133adenosine receptor signaling pathway (GO:0001973)2.30715832
134cell-matrix adhesion (GO:0007160)2.27977276
135negative regulation of protein localization to plasma membrane (GO:1903077)2.26974917
136regulation of extracellular matrix disassembly (GO:0010715)2.24873298
137kidney mesenchyme development (GO:0072074)2.24603873
138negative regulation of vascular permeability (GO:0043116)2.24334356
139positive regulation of osteoblast proliferation (GO:0033690)2.23497558
140cellular response to epinephrine stimulus (GO:0071872)2.23061628
141metanephric mesenchyme development (GO:0072075)2.22644058
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.21366335
143patterning of blood vessels (GO:0001569)2.20806814
144cGMP-mediated signaling (GO:0019934)2.20801684
145positive regulation of p38MAPK cascade (GO:1900745)2.20735403
146regulation of lipoprotein metabolic process (GO:0050746)2.19939788
147regulation of p38MAPK cascade (GO:1900744)2.18698518
148regulation of early endosome to late endosome transport (GO:2000641)2.18537997

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.02963048
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.17172679
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.07444899
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.83955006
5CLOCK_20551151_ChIP-Seq_293T_Human3.48266266
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.20228132
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.12416231
8* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.80843760
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.79394201
10CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.61493054
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59723258
12CJUN_26792858_Chip-Seq_BT549_Human2.56490202
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.49537286
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.40053962
15CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.33280611
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.32708611
17ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.20769592
18* ELK3_25401928_ChIP-Seq_HUVEC_Human2.20350161
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.19020955
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02341851
21NRF2_20460467_ChIP-Seq_MEFs_Mouse2.01143592
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.01143592
23* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.98439933
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.98302749
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97640837
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.90364717
27BRD4_25478319_ChIP-Seq_HGPS_Human1.86084520
28GATA2_21666600_ChIP-Seq_HMVEC_Human1.85842419
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.83491685
30PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79163799
31JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.78752504
32ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.73636024
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.72747107
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.70612076
35JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.63335262
36SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.62606324
37SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.62606324
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.61810853
39SMC1_22415368_ChIP-Seq_MEFs_Mouse1.60109502
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59122626
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55538606
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51695695
43SOX2_20726797_ChIP-Seq_SW620_Human1.49597825
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40899049
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.40234250
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39320853
47GATA1_19941826_ChIP-Seq_K562_Human1.39214357
48CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.36236451
49TP53_18474530_ChIP-ChIP_U2OS_Human1.33745651
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33019960
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.32619893
52SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31175769
53SMC3_22415368_ChIP-Seq_MEFs_Mouse1.28549885
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.26845383
55TBX20_22328084_ChIP-Seq_HEART_Mouse1.26177988
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.26177988
57UBF1/2_26484160_Chip-Seq_HMECs_Human1.25687417
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.25626640
59SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23534046
60P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20123337
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19292924
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.16702668
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16648013
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16398407
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15810648
66TP53_23651856_ChIP-Seq_MEFs_Mouse1.15796555
67TP53_16413492_ChIP-PET_HCT116_Human1.15557087
68MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.15315832
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15273364
70* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14151278
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12839550
72TP53_22127205_ChIP-Seq_IMR90_Human1.12621999
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11904474
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11267913
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.11098691
76NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11063245
77BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10213227
78RACK7_27058665_Chip-Seq_MCF-7_Human1.10168301
79PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10070058
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09945396
81* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09306344
82ATF3_27146783_Chip-Seq_COLON_Human1.07721645
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.06729876
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.06701848
85KDM2B_26808549_Chip-Seq_K562_Human1.05978372
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05117352
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03884887
88* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.99540943
89IKZF1_21737484_ChIP-ChIP_HCT116_Human0.99268836
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98882714
91RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98641282
92EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98641282
93NFI_21473784_ChIP-Seq_ESCs_Mouse0.98242371
94* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98080403
95* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97750723
96MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97551475
97LXR_22292898_ChIP-Seq_THP-1_Human0.97014799
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97012186
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96533952
100SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96190529
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95973807
102DROSHA_22980978_ChIP-Seq_HELA_Human0.95816267
103LXR_22158963_ChIP-Seq_LIVER_Mouse0.95061467
104SA1_22415368_ChIP-Seq_MEFs_Mouse0.94822941
105GATA2_19941826_ChIP-Seq_K562_Human0.94809171
106* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94189236
107* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.93658111
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92060440
109PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91744238
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91242901
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91149176
112SCL_19346495_ChIP-Seq_HPC-7_Human0.89905032
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89808602
114STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88230668
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86972983
116SPI1_23127762_ChIP-Seq_K562_Human0.86752313
117KDM2B_26808549_Chip-Seq_DND41_Human0.86681215
118VDR_24787735_ChIP-Seq_THP-1_Human0.86381234
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86193246
120NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.86145291
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85313131
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84741253
123TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84467687
124CSB_26484114_Chip-Seq_FIBROBLAST_Human0.82974913
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82771532
126ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82681129
127FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.82467374
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.81914643
129FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81376023
130ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79338480
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.78804785
132PPARA_22158963_ChIP-Seq_LIVER_Mouse0.76752279
133TP63_23658742_ChIP-Seq_EP156T_Human0.74605406
134JARID2_20075857_ChIP-Seq_MESCs_Mouse0.74521321
135ELK1_22589737_ChIP-Seq_MCF10A_Human0.73671288

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.99490888
2MP0003279_aneurysm5.29638912
3MP0005275_abnormal_skin_tensile4.81546357
4MP0003705_abnormal_hypodermis_morpholog4.68316574
5MP0005503_abnormal_tendon_morphology4.51816895
6MP0001958_emphysema3.94249715
7MP0009384_cardiac_valve_regurgitation3.37888535
8MP0010368_abnormal_lymphatic_system3.34122790
9MP0006054_spinal_hemorrhage3.21668417
10MP0004272_abnormal_basement_membrane2.80456966
11MP0002295_abnormal_pulmonary_circulatio2.55732764
12MP0003724_increased_susceptibility_to2.39430936
13MP0005623_abnormal_meninges_morphology2.28882853
14MP0005023_abnormal_wound_healing2.24305152
15MP0001879_abnormal_lymphatic_vessel2.22096069
16MP0003566_abnormal_cell_adhesion2.20332823
17MP0000013_abnormal_adipose_tissue2.11405519
18MP0005464_abnormal_platelet_physiology2.10862681
19MP0003091_abnormal_cell_migration1.91109710
20MP0005508_abnormal_skeleton_morphology1.86461640
21MP0005167_abnormal_blood-brain_barrier1.80713594
22MP0000767_abnormal_smooth_muscle1.80018620
23MP0001542_abnormal_bone_strength1.77516954
24MP0002060_abnormal_skin_morphology1.66290544
25MP0010352_gastrointestinal_tract_polyps1.64837119
26MP0002933_joint_inflammation1.61506551
27MP0001243_abnormal_dermal_layer1.58536102
28MP0005257_abnormal_intraocular_pressure1.53582129
29MP0004036_abnormal_muscle_relaxation1.51318554
30MP0005390_skeleton_phenotype1.39530339
31MP0005058_abnormal_lysosome_morphology1.38118635
32MP0005595_abnormal_vascular_smooth1.35589519
33MP0001533_abnormal_skeleton_physiology1.35184129
34MP0000465_gastrointestinal_hemorrhage1.33721631
35MP0009840_abnormal_foam_cell1.29109413
36MP0003385_abnormal_body_wall1.27287147
37MP0000343_altered_response_to1.27246035
38MP0003300_gastrointestinal_ulcer1.23003005
39MP0002108_abnormal_muscle_morphology1.17817176
40MP0005164_abnormal_response_to1.14920423
41MP0000230_abnormal_systemic_arterial1.10251724
42MP0010030_abnormal_orbit_morphology1.10101906
43MP0008004_abnormal_stomach_pH1.10076295
44MP0005409_darkened_coat_color1.09392187
45MP0009780_abnormal_chondrocyte_physiolo1.07635718
46MP0002128_abnormal_blood_circulation1.07453934
47MP0000003_abnormal_adipose_tissue1.06581661
48MP0002998_abnormal_bone_remodeling1.06087201
49MP0009250_abnormal_appendicular_skeleto1.05435071
50MP0003950_abnormal_plasma_membrane1.04959163
51MP0002896_abnormal_bone_mineralization1.03935899
52MP0004130_abnormal_muscle_cell1.02907796
53MP0008775_abnormal_heart_ventricle1.02059170
54MP0002972_abnormal_cardiac_muscle0.96079266
55MP0003045_fibrosis0.95820841
56MP0003075_altered_response_to0.95141173
57MP0000249_abnormal_blood_vessel0.95021867
58MP0000750_abnormal_muscle_regeneration0.95015086
59MP0003828_pulmonary_edema0.95014876
60MP0005084_abnormal_gallbladder_morpholo0.94620166
61MP0005165_increased_susceptibility_to0.93789697
62MP0001614_abnormal_blood_vessel0.93318444
63MP0003448_altered_tumor_morphology0.92334927
64MP0004084_abnormal_cardiac_muscle0.91790171
65MP0003303_peritoneal_inflammation0.91788659
66MP0002168_other_aberrant_phenotype0.91764114
67MP0005666_abnormal_adipose_tissue0.91477766
68MP0001849_ear_inflammation0.90627050
69MP0001348_abnormal_lacrimal_gland0.89804473
70MP0005388_respiratory_system_phenotype0.88187831
71MP0002133_abnormal_respiratory_system0.88187831
72MP0002127_abnormal_cardiovascular_syste0.87704725
73MP0000163_abnormal_cartilage_morphology0.87649147
74MP0002254_reproductive_system_inflammat0.84849732
75MP0004858_abnormal_nervous_system0.84394094
76MP0000733_abnormal_muscle_development0.84209025
77MP0002877_abnormal_melanocyte_morpholog0.83175317
78MP0001851_eye_inflammation0.83077220
79MP0002282_abnormal_trachea_morphology0.82705480
80MP0001299_abnormal_eye_distance/0.81449269
81MP0003011_delayed_dark_adaptation0.80402205
82MP0004134_abnormal_chest_morphology0.80262817
83MP0004883_abnormal_blood_vessel0.79060215
84MP0001915_intracranial_hemorrhage0.76734194
85MP0002115_abnormal_skeleton_extremities0.76379061
86MP0003795_abnormal_bone_structure0.76251332
87MP0005171_absent_coat_pigmentation0.75518641
88MP0004215_abnormal_myocardial_fiber0.73239873
89MP0001175_abnormal_lung_morphology0.72419384
90MP0002113_abnormal_skeleton_development0.72185155
91MP0000858_altered_metastatic_potential0.72023934
92MP0002971_abnormal_brown_adipose0.71507755
93MP0004484_altered_response_of0.70470053
94MP0005369_muscle_phenotype0.69110354
95MP0003436_decreased_susceptibility_to0.66898655
96MP0004947_skin_inflammation0.65867740
97MP0002332_abnormal_exercise_endurance0.65533824
98MP0002932_abnormal_joint_morphology0.64823957
99MP0003115_abnormal_respiratory_system0.64632639
100MP0002925_abnormal_cardiovascular_devel0.64028888
101MP0006138_congestive_heart_failure0.61848322
102MP0003191_abnormal_cellular_cholesterol0.58766352
103MP0000759_abnormal_skeletal_muscle0.58115736
104MP0004782_abnormal_surfactant_physiolog0.58013553
105MP0003453_abnormal_keratinocyte_physiol0.57703349
106MP0005166_decreased_susceptibility_to0.57545204
107MP0002106_abnormal_muscle_physiology0.57104509
108MP0001177_atelectasis0.56410299
109MP0000751_myopathy0.54461170
110MP0009764_decreased_sensitivity_to0.54256436
111MP0000749_muscle_degeneration0.53984168
112MP0002405_respiratory_system_inflammati0.52362180
113MP0002089_abnormal_postnatal_growth/wei0.51677776
114MP0005330_cardiomyopathy0.50829601
115MP0005375_adipose_tissue_phenotype0.50780604
116MP0001853_heart_inflammation0.50143736
117MP0005670_abnormal_white_adipose0.50040123
118MP0009053_abnormal_anal_canal0.48940703
119MP0005385_cardiovascular_system_phenoty0.47914521
120MP0001544_abnormal_cardiovascular_syste0.47914521
121MP0004510_myositis0.47431267
122MP0005193_abnormal_anterior_eye0.45745308
123MP0005197_abnormal_uvea_morphology0.45535624
124MP0004808_abnormal_hematopoietic_stem0.45517660
125MP0005620_abnormal_muscle_contractility0.45432146
126MP0004087_abnormal_muscle_fiber0.44951280
127MP0009278_abnormal_bone_marrow0.44333080
128MP0003941_abnormal_skin_development0.43827210
129MP0003942_abnormal_urinary_system0.43361018

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)9.53806070
2Premature rupture of membranes (HP:0001788)8.92049620
3Aortic aneurysm (HP:0004942)5.97904344
4Peritonitis (HP:0002586)5.80420154
5Aortic dissection (HP:0002647)5.79219828
6Soft skin (HP:0000977)5.24310987
7Dilatation of the ascending aorta (HP:0005111)4.70414318
8Vertebral compression fractures (HP:0002953)4.68302560
9Cerebral aneurysm (HP:0004944)4.59253706
10Bladder diverticulum (HP:0000015)4.51900791
11Shallow orbits (HP:0000586)4.49676410
12Vascular tortuosity (HP:0004948)4.39700885
13Atrophic scars (HP:0001075)4.34717744
14Broad metatarsal (HP:0001783)4.25750786
15Abnormality of dentin (HP:0010299)4.06517873
16Arterial tortuosity (HP:0005116)4.05608294
17Biconcave vertebral bodies (HP:0004586)3.93877150
18Fragile skin (HP:0001030)3.90409875
19Wormian bones (HP:0002645)3.87956168
20Menorrhagia (HP:0000132)3.72032387
21Nonimmune hydrops fetalis (HP:0001790)3.64039739
22Prolonged bleeding time (HP:0003010)3.63555987
23Blue sclerae (HP:0000592)3.62355492
24Overgrowth (HP:0001548)3.56683807
25Spontaneous hematomas (HP:0007420)3.47895011
26Wrist flexion contracture (HP:0001239)3.45228566
27Ankle contracture (HP:0006466)3.39470032
28Increased mean platelet volume (HP:0011877)3.36508790
29Genu recurvatum (HP:0002816)3.35832008
30Cervical subluxation (HP:0003308)3.30565042
31Spinal rigidity (HP:0003306)3.28993751
32Increased connective tissue (HP:0009025)3.16817470
33Aneurysm (HP:0002617)3.15682770
34Bowel diverticulosis (HP:0005222)3.13612334
35Abnormal platelet volume (HP:0011876)3.07900056
36Abnormal delivery (HP:0001787)3.07867725
37Mitral valve prolapse (HP:0001634)3.07717622
38Purpura (HP:0000979)3.07073636
39Ectopia lentis (HP:0001083)2.97371915
40Polycythemia (HP:0001901)2.94657609
41Hyperlipoproteinemia (HP:0010980)2.81916120
42Follicular hyperkeratosis (HP:0007502)2.81892308
43Hyperextensible skin (HP:0000974)2.80126702
44Epistaxis (HP:0000421)2.78153961
45Joint stiffness (HP:0001387)2.76043561
46Abnormality of the peritoneum (HP:0002585)2.74064165
47Abnormality of the acetabulum (HP:0003170)2.71731677
48Type 1 muscle fiber predominance (HP:0003803)2.70895856
49Infantile muscular hypotonia (HP:0008947)2.69252404
50Systemic lupus erythematosus (HP:0002725)2.68006845
51Neonatal short-limb short stature (HP:0008921)2.67071538
52Round ear (HP:0100830)2.60471164
53Coxa vara (HP:0002812)2.60082986
54Petechiae (HP:0000967)2.55317779
55Spondylolisthesis (HP:0003302)2.55000695
56Conjunctival telangiectasia (HP:0000524)2.48829104
57Hematochezia (HP:0002573)2.44325147
58Elbow flexion contracture (HP:0002987)2.43574168
59Venous abnormality (HP:0002624)2.40682237
60Gingival bleeding (HP:0000225)2.37642294
61Mitral stenosis (HP:0001718)2.33834842
62Venous insufficiency (HP:0005293)2.31909753
63Complement deficiency (HP:0004431)2.31621296
64Camptodactyly of toe (HP:0001836)2.30138855
65Thin bony cortex (HP:0002753)2.30129844
66Distal lower limb muscle weakness (HP:0009053)2.29787414
67Short nail (HP:0001799)2.29319014
68Abnormality of complement system (HP:0005339)2.27069358
69Asymmetric septal hypertrophy (HP:0001670)2.26183937
70Pulmonary artery stenosis (HP:0004415)2.20059204
71Joint laxity (HP:0001388)2.19568912
72Hyporeflexia of lower limbs (HP:0002600)2.18830506
73Abnormal platelet function (HP:0011869)2.17713174
74Impaired platelet aggregation (HP:0003540)2.17713174
75Osteolytic defects of the hand bones (HP:0009699)2.16949160
76Osteolytic defects of the phalanges of the hand (HP:0009771)2.16949160
77Cardiovascular calcification (HP:0011915)2.15686607
78Abnormality of the vasculature of the conjunctiva (HP:0008054)2.12124736
79Esophageal varix (HP:0002040)2.12056523
80Aortic valve stenosis (HP:0001650)2.11374794
81Bruising susceptibility (HP:0000978)2.10665903
82Wide anterior fontanel (HP:0000260)2.09975025
83Dysostosis multiplex (HP:0000943)2.08789246
84Increased variability in muscle fiber diameter (HP:0003557)2.07064264
85Breech presentation (HP:0001623)2.06398904
86Beaking of vertebral bodies (HP:0004568)2.05856239
87Mitral regurgitation (HP:0001653)2.03538827
88Congenital glaucoma (HP:0001087)2.02498197
89Short hallux (HP:0010109)2.00703963
90Abnormality of the anterior chamber (HP:0000593)1.99572047
91Broad ribs (HP:0000885)1.99127694
92Chondrocalcinosis (HP:0000934)1.97565136
93Interstitial pulmonary disease (HP:0006530)1.93316333
94Slender build (HP:0001533)1.92231209
95Thin skin (HP:0000963)1.91488057
96Upper limb amyotrophy (HP:0009129)1.89123391
97Distal upper limb amyotrophy (HP:0007149)1.89123391
98Axonal loss (HP:0003447)1.88977541
99Lymphangioma (HP:0100764)1.87014558
100Flexion contracture of toe (HP:0005830)1.85262490
101Joint contractures involving the joints of the feet (HP:0100492)1.85262490
102Abnormality of Sharpey fibers (HP:0100685)1.84876296
103Increased density of long bones (HP:0006392)1.84506847
104Bradycardia (HP:0001662)1.84455805
105Abnormality of skeletal muscle fiber size (HP:0012084)1.84172625
106Mildly elevated creatine phosphokinase (HP:0008180)1.82837368
107Emphysema (HP:0002097)1.82289916
108Hemorrhage of the eye (HP:0011885)1.81925637
109Osteoarthritis (HP:0002758)1.81499266
110Aplasia/Hypoplasia of the hallux (HP:0008362)1.81406288
111Obstructive sleep apnea (HP:0002870)1.80711061
112Osteopenia (HP:0000938)1.79569454
113Difficulty climbing stairs (HP:0003551)1.78183831
114Hypoventilation (HP:0002791)1.75753043
115Deviation of the hallux (HP:0010051)1.75414152
116Aortic regurgitation (HP:0001659)1.75062666
117Stroke (HP:0001297)1.74872008
118Right ventricular cardiomyopathy (HP:0011663)1.74810169
119Platyspondyly (HP:0000926)1.73884491
120Decreased skull ossification (HP:0004331)1.73751444
121Persistence of primary teeth (HP:0006335)1.73658499
122Delayed cranial suture closure (HP:0000270)1.73425275
123Abnormality of skull ossification (HP:0002703)1.72594584
124Pulmonary hypertension (HP:0002092)1.72228379
125Tibial bowing (HP:0002982)1.72010489
126Hip contracture (HP:0003273)1.70533195
127Muscle fiber splitting (HP:0003555)1.70282326
128Mucopolysacchariduria (HP:0008155)1.70013653
129Urinary glycosaminoglycan excretion (HP:0003541)1.70013653
130Myocardial infarction (HP:0001658)1.69997513
131Gastrointestinal dysmotility (HP:0002579)1.68375691
132Hallux valgus (HP:0001822)1.68285308
133Decreased subcutaneous fat (HP:0001002)1.68200155
134Mesomelia (HP:0003027)1.67158599
135Striae distensae (HP:0001065)1.66350761
136Hypoplasia of the iris (HP:0007676)1.65109209
137Distal lower limb amyotrophy (HP:0008944)1.64477481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.83250414
2ERN14.11503114
3LATS23.69456946
4TIE13.42255864
5TTN3.20210161
6DDR22.79958884
7TRIB32.78200930
8PDGFRA2.63439450
9TGFBR22.51258642
10TESK12.42242974
11PIM22.19870806
12PTK2B2.16553864
13EPHA32.16512477
14MYLK2.12374364
15LIMK12.00954767
16EPHB11.94370177
17EPHB21.88861861
18FER1.84847170
19PAK21.76549470
20PKN21.69498083
21PTK21.67146658
22PIK3CG1.55353928
23GRK51.54083560
24DMPK1.51223218
25JAK31.48449683
26PAK31.47972635
27TESK21.46996665
28RPS6KA41.44258608
29RIPK11.43411764
30LATS11.35824725
31MAP3K31.34326868
32TRPM71.33846419
33FGFR41.27092281
34BMX1.27078322
35MAP3K61.25689856
36TGFBR11.22922388
37PIK3CA1.17673377
38MOS1.17285432
39TBK11.15068384
40LMTK21.12623552
41LRRK21.05489048
42TAOK11.01758160
43PRPF4B1.00898918
44NEK91.00862489
45MET1.00748639
46PTK60.98866485
47KIT0.96433176
48NME20.96424214
49JAK10.95587844
50FES0.94188683
51SIK10.92071237
52MAP3K110.88209823
53MAP2K30.87205051
54PDGFRB0.87003757
55STK100.85831142
56OBSCN0.83049924
57ABL20.80851501
58PRKD10.80611579
59FLT30.79405691
60BTK0.78023619
61ADRBK10.77936746
62MAP2K10.75389687
63ROCK10.74516998
64RIPK40.74448209
65PDPK10.73006552
66TAOK20.71995650
67PAK40.71733164
68IRAK30.71582659
69FGFR10.71177414
70DAPK30.69215363
71RPS6KA20.69075643
72STK380.68812066
73TYK20.68500355
74GRK10.67831122
75MARK20.65777699
76INSR0.65249146
77PRKAA20.64603560
78MAPKAPK30.64445893
79PRKG20.64364172
80MAP3K140.63195721
81MAPK40.62479128
82PAK10.61919704
83NTRK10.61129675
84MAP3K70.60196226
85HIPK20.59781588
86CSK0.59591648
87PRKCH0.59412740
88BLK0.59248279
89ZAP700.57721750
90GSK3A0.56766321
91EPHA20.56621822
92ILK0.53060014
93IKBKB0.48272216
94RET0.47732680
95PDK20.47605402
96CDC42BPA0.46645750
97CAMK10.46295514
98TEC0.45896529
99SRC0.44687105
100ADRBK20.44676878
101PRKD20.44288633
102MAPK120.43360996
103HCK0.42872673
104STK30.42732069
105MTOR0.41830810
106ARAF0.41692560
107MAP3K10.41442149
108ERBB30.40523057
109GRK60.40453081
110MAP3K130.40394879
111IRAK10.40196351
112PKN10.39777743
113ROCK20.39550977
114ERBB40.38841251
115RPS6KL10.37396548
116RPS6KC10.37396548
117IGF1R0.36330880
118FGFR30.35915945
119AKT30.32850471
120ABL10.31635215
121PLK20.31629899
122EGFR0.30862376
123MAPKAPK20.30409588
124MAP3K80.28329610
125MAPKAPK50.27785466
126STK38L0.26830014
127MAPK70.26390619
128NLK0.25948960

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.90240251
2Malaria_Homo sapiens_hsa051443.72746085
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.71452609
4Focal adhesion_Homo sapiens_hsa045102.93161720
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.55666387
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.16883763
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.16298637
8Proteoglycans in cancer_Homo sapiens_hsa052052.06173440
9Dilated cardiomyopathy_Homo sapiens_hsa054142.04688533
10Amoebiasis_Homo sapiens_hsa051462.00306371
11Shigellosis_Homo sapiens_hsa051311.98563289
12Bladder cancer_Homo sapiens_hsa052191.81038614
13Complement and coagulation cascades_Homo sapiens_hsa046101.76674505
14Adherens junction_Homo sapiens_hsa045201.74633135
15TGF-beta signaling pathway_Homo sapiens_hsa043501.73262189
16Protein digestion and absorption_Homo sapiens_hsa049741.72955491
17TNF signaling pathway_Homo sapiens_hsa046681.72480641
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69081345
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.61402662
20PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59637591
21Phagosome_Homo sapiens_hsa041451.51760775
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.44647083
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.43215310
24Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42032247
25Rheumatoid arthritis_Homo sapiens_hsa053231.41726955
26MicroRNAs in cancer_Homo sapiens_hsa052061.35856077
27Viral myocarditis_Homo sapiens_hsa054161.35390747
28Small cell lung cancer_Homo sapiens_hsa052221.30727423
29Leishmaniasis_Homo sapiens_hsa051401.24467696
30Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19561890
31Rap1 signaling pathway_Homo sapiens_hsa040151.19502520
32Pertussis_Homo sapiens_hsa051331.16450643
33Toxoplasmosis_Homo sapiens_hsa051451.12271276
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10889917
35p53 signaling pathway_Homo sapiens_hsa041151.10614745
36Salmonella infection_Homo sapiens_hsa051321.09662724
37HIF-1 signaling pathway_Homo sapiens_hsa040661.09438855
38Platelet activation_Homo sapiens_hsa046111.08714009
39Chronic myeloid leukemia_Homo sapiens_hsa052201.05180307
40Hippo signaling pathway_Homo sapiens_hsa043901.04708993
41Melanoma_Homo sapiens_hsa052181.04268272
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.04144902
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03677505
44Osteoclast differentiation_Homo sapiens_hsa043801.01621062
45Renin secretion_Homo sapiens_hsa049240.97401379
46Pancreatic cancer_Homo sapiens_hsa052120.95087633
47Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91998312
48Apoptosis_Homo sapiens_hsa042100.91477008
49Hematopoietic cell lineage_Homo sapiens_hsa046400.89753006
50NF-kappa B signaling pathway_Homo sapiens_hsa040640.85962819
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.85254426
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84892452
53Lysosome_Homo sapiens_hsa041420.81882932
54Arachidonic acid metabolism_Homo sapiens_hsa005900.77920250
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.76457955
56Jak-STAT signaling pathway_Homo sapiens_hsa046300.75522621
57Dorso-ventral axis formation_Homo sapiens_hsa043200.75411378
58African trypanosomiasis_Homo sapiens_hsa051430.75407050
59Tuberculosis_Homo sapiens_hsa051520.74840727
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74154192
61HTLV-I infection_Homo sapiens_hsa051660.73858449
62Pathways in cancer_Homo sapiens_hsa052000.73231057
63GnRH signaling pathway_Homo sapiens_hsa049120.72848124
64Hepatitis B_Homo sapiens_hsa051610.72780501
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72067192
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71973152
67Renal cell carcinoma_Homo sapiens_hsa052110.69194190
68Ras signaling pathway_Homo sapiens_hsa040140.68571553
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67699970
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67195733
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66704090
72Legionellosis_Homo sapiens_hsa051340.65010508
73Oxytocin signaling pathway_Homo sapiens_hsa049210.64334163
74Prion diseases_Homo sapiens_hsa050200.64200879
75Staphylococcus aureus infection_Homo sapiens_hsa051500.61405840
76Renin-angiotensin system_Homo sapiens_hsa046140.61105485
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60642192
78Choline metabolism in cancer_Homo sapiens_hsa052310.60605957
79Measles_Homo sapiens_hsa051620.59553183
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58533006
81Calcium signaling pathway_Homo sapiens_hsa040200.58137774
82Prostate cancer_Homo sapiens_hsa052150.57550403
83Endocytosis_Homo sapiens_hsa041440.55381359
84Arginine and proline metabolism_Homo sapiens_hsa003300.55235371
85Tight junction_Homo sapiens_hsa045300.55229408
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.54539778
87Caffeine metabolism_Homo sapiens_hsa002320.54519784
88Ovarian steroidogenesis_Homo sapiens_hsa049130.53915937
89Vibrio cholerae infection_Homo sapiens_hsa051100.53571570
90VEGF signaling pathway_Homo sapiens_hsa043700.52097398
91Axon guidance_Homo sapiens_hsa043600.50174564
92Acute myeloid leukemia_Homo sapiens_hsa052210.50102739
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49622918
94Other glycan degradation_Homo sapiens_hsa005110.49106092
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.48366091
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.47968968
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47663187
98Chemokine signaling pathway_Homo sapiens_hsa040620.47315166
99PPAR signaling pathway_Homo sapiens_hsa033200.46717520
100Sphingolipid metabolism_Homo sapiens_hsa006000.46553185
101Insulin signaling pathway_Homo sapiens_hsa049100.46539016
102Gastric acid secretion_Homo sapiens_hsa049710.45556242
103Glycerolipid metabolism_Homo sapiens_hsa005610.45426977
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45326794
105Estrogen signaling pathway_Homo sapiens_hsa049150.45235692
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.45084411
107Pancreatic secretion_Homo sapiens_hsa049720.44083442
108cAMP signaling pathway_Homo sapiens_hsa040240.43888625
109Insulin resistance_Homo sapiens_hsa049310.43716944
110Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43425425
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.43070822
112Tyrosine metabolism_Homo sapiens_hsa003500.42411234
113Mineral absorption_Homo sapiens_hsa049780.41678729
114Gap junction_Homo sapiens_hsa045400.41230086
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.38800674
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38485230
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37374143
118Glioma_Homo sapiens_hsa052140.35233294
119Chemical carcinogenesis_Homo sapiens_hsa052040.34589158
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33004649
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33002586
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31017868
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30574986
124Hepatitis C_Homo sapiens_hsa051600.30377061
125Viral carcinogenesis_Homo sapiens_hsa052030.30120514
126Influenza A_Homo sapiens_hsa051640.29668032
127Notch signaling pathway_Homo sapiens_hsa043300.29301152
128MAPK signaling pathway_Homo sapiens_hsa040100.28774568
129Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27755866
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.27192131

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