LRRC29

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 9 tandem leucine-rich repeats. Two transcript variants encoding the same protein have been found for this gene. Other variants may occur, but their full-length natures have not been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mast cell activation involved in immune response (GO:0002279)9.45837091
2mast cell degranulation (GO:0043303)9.45837091
3hepatocyte apoptotic process (GO:0097284)9.06756631
4regulation of fibroblast apoptotic process (GO:2000269)7.47038547
5adenosine receptor signaling pathway (GO:0001973)7.12607353
6histone H3-K36 demethylation (GO:0070544)6.97303184
7mast cell activation (GO:0045576)6.84574128
8T cell migration (GO:0072678)6.83398451
9positive regulation of protein kinase C signaling (GO:0090037)6.58356672
10mannosylation (GO:0097502)6.51608985
11respiratory burst (GO:0045730)6.21874691
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.80358621
13daunorubicin metabolic process (GO:0044597)5.63648012
14polyketide metabolic process (GO:0030638)5.63648012
15doxorubicin metabolic process (GO:0044598)5.63648012
16GDP-mannose metabolic process (GO:0019673)5.57567830
17sperm motility (GO:0030317)5.54853231
18purinergic nucleotide receptor signaling pathway (GO:0035590)5.41926196
19motile cilium assembly (GO:0044458)5.38342021
20regulation of cilium movement (GO:0003352)5.37782699
21dendritic cell chemotaxis (GO:0002407)5.24352411
22amyloid precursor protein catabolic process (GO:0042987)5.22930572
23negative regulation of lipid catabolic process (GO:0050995)5.18785037
24somatic diversification of immune receptors via somatic mutation (GO:0002566)5.13227834
25somatic hypermutation of immunoglobulin genes (GO:0016446)5.13227834
26negative regulation of cell aging (GO:0090344)5.11288463
27lysosome localization (GO:0032418)5.10262348
28lymphocyte chemotaxis (GO:0048247)5.05195534
29phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.82776777
30fusion of sperm to egg plasma membrane (GO:0007342)4.80723385
31cellular response to ATP (GO:0071318)4.78150783
32purinergic receptor signaling pathway (GO:0035587)4.75161923
33acrosome reaction (GO:0007340)4.73093783
34leukocyte degranulation (GO:0043299)4.68472706
35G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.65800052
36regulation of skeletal muscle contraction (GO:0014819)4.62714712
37macroautophagy (GO:0016236)4.55817484
38rRNA methylation (GO:0031167)4.55490780
39intracellular pH reduction (GO:0051452)4.54807032
40cilium or flagellum-dependent cell motility (GO:0001539)4.47933793
41UV protection (GO:0009650)4.43619074
42NIK/NF-kappaB signaling (GO:0038061)4.39852621
43sperm-egg recognition (GO:0035036)4.38039991
44regulation of triglyceride metabolic process (GO:0090207)4.35489332
45purine ribonucleotide transport (GO:0015868)4.32059744
46lens fiber cell differentiation (GO:0070306)4.15887106
47phosphatidylinositol 3-kinase signaling (GO:0014065)4.14821619
48axonemal dynein complex assembly (GO:0070286)4.10610251
49binding of sperm to zona pellucida (GO:0007339)4.09317271
50adenine nucleotide transport (GO:0051503)4.09307860
51cardiolipin metabolic process (GO:0032048)4.03626157
52cell-cell recognition (GO:0009988)3.99156228
53peptidyl-glutamic acid carboxylation (GO:0017187)3.96037563
54protein carboxylation (GO:0018214)3.96037563
55lymphoid progenitor cell differentiation (GO:0002320)3.95302280
56response to peptidoglycan (GO:0032494)3.93653208
57cell wall macromolecule catabolic process (GO:0016998)3.93463475
58cell wall macromolecule metabolic process (GO:0044036)3.93463475
59spermatid development (GO:0007286)3.92492353
60regulation of hydrogen peroxide metabolic process (GO:0010310)3.89211826
61negative regulation of erythrocyte differentiation (GO:0045647)3.86458239
62negative regulation of macroautophagy (GO:0016242)3.85456400
63rRNA modification (GO:0000154)3.84730861
64dendritic cell migration (GO:0036336)3.80248378
65acrosome assembly (GO:0001675)3.76487800
66response to ATP (GO:0033198)3.72907938
67negative regulation of muscle contraction (GO:0045932)3.72091052
68aminoglycoside antibiotic metabolic process (GO:0030647)3.63734783
69pH reduction (GO:0045851)3.63154249
70negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.61159792
71multicellular organism reproduction (GO:0032504)3.61027233
72amyloid precursor protein metabolic process (GO:0042982)3.50720273
73regulation of cytokine production involved in inflammatory response (GO:1900015)3.49828371
74negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.48225814
75plasma membrane fusion (GO:0045026)3.44611489
76regulation of inclusion body assembly (GO:0090083)3.39338039
77negative regulation of tumor necrosis factor production (GO:0032720)3.37527122
78epithelial cilium movement (GO:0003351)3.36801434
79organic cation transport (GO:0015695)3.34752431
80male meiosis (GO:0007140)3.33902811
81phosphatidylglycerol biosynthetic process (GO:0006655)3.33558194
82regulation of mast cell degranulation (GO:0043304)3.33171026
83DNA strand renaturation (GO:0000733)3.32801043
84phosphatidylinositol phosphorylation (GO:0046854)3.32278641
85neutrophil activation involved in immune response (GO:0002283)3.32115624
86lymphocyte migration (GO:0072676)3.31505798
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.30883453
88autophagic vacuole fusion (GO:0000046)3.30314634
89regulated secretory pathway (GO:0045055)3.29526681
90negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.27237749
91germinal center formation (GO:0002467)3.27215522
92granulocyte differentiation (GO:0030851)3.27157984
93negative regulation of heart contraction (GO:0045822)3.27136006
94regulation of lipid catabolic process (GO:0050994)3.26191605
95neurotransmitter biosynthetic process (GO:0042136)3.25601270
96sensory perception of taste (GO:0050909)3.25027172
97positive regulation of acute inflammatory response (GO:0002675)3.23359224
98mature B cell differentiation involved in immune response (GO:0002313)3.21613374
99regulation of synapse structural plasticity (GO:0051823)3.21548671
100purine nucleotide transport (GO:0015865)3.17887660
101regulation of cellular pH (GO:0030641)3.17294799
102thrombin receptor signaling pathway (GO:0070493)3.16924697
103mannose metabolic process (GO:0006013)3.16869192
104protein localization to cilium (GO:0061512)3.15875264
105myeloid cell activation involved in immune response (GO:0002275)3.13943472
106neurotransmitter metabolic process (GO:0042133)3.09803453
107cilium movement (GO:0003341)3.08759281
108lipid phosphorylation (GO:0046834)3.02898031
109reproduction (GO:0000003)3.01911768
110T cell proliferation (GO:0042098)3.01036188
111response to muramyl dipeptide (GO:0032495)3.00037083
112protoporphyrinogen IX metabolic process (GO:0046501)2.93392364
113regulation of mast cell activation involved in immune response (GO:0033006)2.93291404
114piRNA metabolic process (GO:0034587)2.93152319
115urinary tract smooth muscle contraction (GO:0014848)2.92978288
116protein polyglutamylation (GO:0018095)2.92766429
117estrogen biosynthetic process (GO:0006703)2.91486877
118meiotic chromosome segregation (GO:0045132)2.91427400
119glutathione biosynthetic process (GO:0006750)2.90024724
120regulation of interferon-beta biosynthetic process (GO:0045357)2.90021103
121growth hormone receptor signaling pathway (GO:0060396)2.87652088
122protoporphyrinogen IX biosynthetic process (GO:0006782)2.86395740
123glutathione derivative metabolic process (GO:1901685)2.86337592
124glutathione derivative biosynthetic process (GO:1901687)2.86337592
125cellular copper ion homeostasis (GO:0006878)2.86080213
126regulation of intracellular pH (GO:0051453)2.84268577
127single fertilization (GO:0007338)2.83608753
128regulation of protein kinase C signaling (GO:0090036)2.83315945
129nucleoside transmembrane transport (GO:1901642)2.82575580
130Rap protein signal transduction (GO:0032486)2.81100697
131regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.80591111
132negative regulation of interleukin-12 production (GO:0032695)2.80010745
133sperm capacitation (GO:0048240)2.79959445
134regulation of tumor necrosis factor production (GO:0032680)2.79876954
135nucleotide transmembrane transport (GO:1901679)2.79576337
136regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77976565
137establishment of protein localization to Golgi (GO:0072600)2.77967152
138negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.77225416
139negative regulation of innate immune response (GO:0045824)2.76136830
140prostate gland growth (GO:0060736)2.75588920
141positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.73784692
142response to methylmercury (GO:0051597)2.73645914
143low-density lipoprotein particle clearance (GO:0034383)2.73434583
144nonribosomal peptide biosynthetic process (GO:0019184)2.72943085
145regulation of protein kinase A signaling (GO:0010738)2.72882494
146L-phenylalanine catabolic process (GO:0006559)2.72173293
147erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.72173293
148organelle membrane fusion (GO:0090174)2.69871949
149regulation of microtubule-based movement (GO:0060632)2.68861255
150negative regulation of interleukin-8 production (GO:0032717)2.68778749
151regulation of leukocyte degranulation (GO:0043300)2.67609901
152definitive hemopoiesis (GO:0060216)2.66796023
153cofactor catabolic process (GO:0051187)2.66518803
154induction of positive chemotaxis (GO:0050930)2.66253324
155regulation of somitogenesis (GO:0014807)2.63529129
156primary alcohol catabolic process (GO:0034310)2.63306921
157purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.60225639
1583-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.60225639
159sialylation (GO:0097503)2.59793472
160melanin biosynthetic process (GO:0042438)2.57852905
161defense response to protozoan (GO:0042832)2.53406756
162Arp2/3 complex-mediated actin nucleation (GO:0034314)2.53328896
163detection of molecule of bacterial origin (GO:0032490)2.51561523
164nucleoside transport (GO:0015858)2.49580115
165gonadal mesoderm development (GO:0007506)2.49236843
166sphingosine metabolic process (GO:0006670)2.48068704
167regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.45771734
168response to protozoan (GO:0001562)2.43818837
169negative regulation of B cell apoptotic process (GO:0002903)2.43406080
170modulation by virus of host process (GO:0019054)2.42699939
171hyaluronan catabolic process (GO:0030214)2.39735786
172positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.39376986
173melanin metabolic process (GO:0006582)2.39198929
174positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.38105518
175antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.37233922
176base-excision repair, AP site formation (GO:0006285)2.36755838
177modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.36434861
178positive regulation by organism of defense response of other organism involved in symbiotic interact2.36434861
179modulation by symbiont of host immune response (GO:0052553)2.36434861
180positive regulation by symbiont of host defense response (GO:0052509)2.36434861
181modulation by symbiont of host defense response (GO:0052031)2.36434861
182modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.36434861
183positive regulation of tumor necrosis factor production (GO:0032760)2.36253842
184positive regulation of lipoprotein lipase activity (GO:0051006)2.32863068
185positive regulation of triglyceride lipase activity (GO:0061365)2.32863068
186regulation of respiratory burst (GO:0060263)2.31620021
187macrophage activation involved in immune response (GO:0002281)2.30915957
188negative regulation of macrophage differentiation (GO:0045650)2.30164568
189endocytic recycling (GO:0032456)2.29709292
190cellular anion homeostasis (GO:0030002)2.29551071
191cellular extravasation (GO:0045123)11.5328504
192negative regulation of fibroblast apoptotic process (GO:2000270)10.6120662
193regulation of triglyceride catabolic process (GO:0010896)10.0943405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human4.32836256
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.26968516
3CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.73012826
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.68000061
5CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.32004117
6SCL_19346495_ChIP-Seq_HPC-7_Human3.30513184
7STAT6_21828071_ChIP-Seq_BEAS2B_Human3.24335295
8ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.24195999
9LXR_22292898_ChIP-Seq_THP-1_Human3.17123483
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.17103825
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.65099235
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61911665
13P68_20966046_ChIP-Seq_HELA_Human2.57669243
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.57378177
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.57062998
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.34483956
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34094895
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.28769921
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.28446589
20LXR_22158963_ChIP-Seq_LIVER_Mouse2.24770721
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.23291418
22* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.17983075
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17577678
24MAF_26560356_Chip-Seq_TH2_Human2.17379294
25GATA1_26923725_Chip-Seq_HPCs_Mouse2.08983934
26KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08819093
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.99704841
28CTCF_27219007_Chip-Seq_ERYTHROID_Human1.99453695
29E2F1_20622854_ChIP-Seq_HELA_Human1.95800016
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.95742852
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90882227
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.89871994
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88041834
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.84472649
35E2F7_22180533_ChIP-Seq_HELA_Human1.84263239
36PHF8_20622854_ChIP-Seq_HELA_Human1.83621943
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.83143928
38KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.82687729
39* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81378778
40KDM2B_26808549_Chip-Seq_DND41_Human1.79512743
41LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.78059724
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.77916261
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.74098184
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73765234
45MYC_22102868_ChIP-Seq_BL_Human1.72152604
46SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71181439
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.70846274
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.70839942
49RACK7_27058665_Chip-Seq_MCF-7_Human1.70822931
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67353239
51GATA1_19941826_ChIP-Seq_K562_Human1.65439743
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.64617685
53CTCF_27219007_Chip-Seq_Bcells_Human1.63952798
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.63930073
55MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.63307745
56RARB_24833708_ChIP-Seq_LIVER_Mouse1.61155228
57NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59602196
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57134613
59CTCF_21964334_Chip-Seq_Bcells_Human1.56827337
60GATA2_19941826_ChIP-Seq_K562_Human1.56823281
61SMC4_20622854_ChIP-Seq_HELA_Human1.56255874
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56173147
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54831387
64* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54795136
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.53874075
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.53035255
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51909429
68P53_21459846_ChIP-Seq_SAOS-2_Human1.47845506
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46873829
70MYB_26560356_Chip-Seq_TH2_Human1.46591805
71FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.46528467
72RARA_24833708_ChIP-Seq_LIVER_Mouse1.45971346
73VDR_21846776_ChIP-Seq_THP-1_Human1.44250608
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43654043
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.41947530
76TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41018167
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.40921773
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38098977
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.37185441
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36733388
81XRN2_22483619_ChIP-Seq_HELA_Human1.36638563
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36315027
83CTCF_20526341_ChIP-Seq_ESCs_Human1.36314544
84ETS1_22383799_ChIP-Seq_G1ME_Mouse1.33056016
85* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32907382
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31306013
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30915805
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30836574
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30800180
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29167507
91CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26904517
92DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26385770
93FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26203198
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.25739858
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.24370023
96MYB_26560356_Chip-Seq_TH1_Human1.24176862
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23545838
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23489291
99* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22707246
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21013334
101NCOR1_26117541_ChIP-Seq_K562_Human1.20942696
102TCF7_22412390_ChIP-Seq_EML_Mouse1.20932482
103FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.20930942
104SA1_27219007_Chip-Seq_Bcells_Human1.20625706
105CREB1_26743006_Chip-Seq_LNCaP_Human1.20520318
106P300_27268052_Chip-Seq_Bcells_Human1.20264131
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19857023
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19515631
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.19137789
110* SRF_21415370_ChIP-Seq_HL-1_Mouse1.17667495
111ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17435924
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16917099
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16330727
114RUNX_20019798_ChIP-Seq_JUKART_Human1.15928514
115JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.14382628
116TP53_22127205_ChIP-Seq_IMR90_Human1.14159863
117ERG_20517297_ChIP-Seq_VCAP_Human1.13159397
118KDM2B_26808549_Chip-Seq_K562_Human1.13118280
119ETS1_21867929_ChIP-Seq_TH2_Mouse1.11513778
120STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11097307
121BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11012481
122NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08670868
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08613608
124SMC3_22415368_ChIP-Seq_MEFs_Mouse1.08370170
125MAF_26560356_Chip-Seq_TH1_Human1.07730551
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06363004
127VDR_24763502_ChIP-Seq_THP-1_Human1.06003933
128BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05865649
129SPI1_20517297_ChIP-Seq_HL60_Human1.04641243
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03027784
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02136663
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01009945
133* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98098607
134GATA3_27048872_Chip-Seq_THYMUS_Human0.97296818
135CTCF_26484167_Chip-Seq_Bcells_Mouse0.95424193
136CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95202217
137GATA3_21867929_ChIP-Seq_CD8_Mouse0.94165951
138CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93409424
139BCOR_27268052_Chip-Seq_Bcells_Human0.92740045
140CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92534995
141TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.91277592
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.90253168
143EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87328963
144YY1_22570637_ChIP-Seq_MALME-3M_Human0.87099250
145RXRA_24833708_ChIP-Seq_LIVER_Mouse0.86723135
146STAT1_20625510_ChIP-Seq_HELA_Human0.86327625
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85719548
148* SPI1_23547873_ChIP-Seq_NB4_Human0.84457375
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84218079
150IRF8_27001747_Chip-Seq_BMDM_Mouse0.83201297
151SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83125138
152UTX_26944678_Chip-Seq_JUKART_Human0.82800839
153* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82097123
154BCL6_27268052_Chip-Seq_Bcells_Human0.80845598
155SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80533207
156CTCF_21964334_ChIP-Seq_BJAB-B_Human0.80219755
157PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.79429545
158CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78048986
159FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78030182

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.86385272
2MP0005171_absent_coat_pigmentation5.07976999
3MP0001986_abnormal_taste_sensitivity5.01372770
4MP0004147_increased_porphyrin_level4.20484650
5MP0008877_abnormal_DNA_methylation3.92541144
6MP0004084_abnormal_cardiac_muscle3.79859810
7MP0003656_abnormal_erythrocyte_physiolo3.58063490
8MP0003136_yellow_coat_color3.42948049
9MP0003436_decreased_susceptibility_to3.30368827
10MP0005423_abnormal_somatic_nervous3.22217322
11MP0003183_abnormal_peptide_metabolism3.14580458
12MP0002396_abnormal_hematopoietic_system2.90379227
13MP0004036_abnormal_muscle_relaxation2.88113511
14MP0002139_abnormal_hepatobiliary_system2.87651805
15MP0001968_abnormal_touch/_nociception2.81401019
16MP0003303_peritoneal_inflammation2.75120391
17MP0005464_abnormal_platelet_physiology2.67880671
18MP0005360_urolithiasis2.61069234
19MP0000013_abnormal_adipose_tissue2.58289217
20MP0003172_abnormal_lysosome_physiology2.43528000
21MP0005409_darkened_coat_color2.36421143
22MP0008058_abnormal_DNA_repair2.31214523
23MP0002877_abnormal_melanocyte_morpholog2.22244033
24MP0005085_abnormal_gallbladder_physiolo2.08582334
25MP0009278_abnormal_bone_marrow2.07554338
26MP0005671_abnormal_response_to2.03965260
27MP0003698_abnormal_male_reproductive2.03574453
28MP0008007_abnormal_cellular_replicative1.96468541
29MP0005365_abnormal_bile_salt1.94196080
30MP0004808_abnormal_hematopoietic_stem1.93042726
31MP0001929_abnormal_gametogenesis1.90492351
32MP0000751_myopathy1.87498737
33MP0008875_abnormal_xenobiotic_pharmacok1.85642752
34MP0010329_abnormal_lipoprotein_level1.85212843
35MP0001835_abnormal_antigen_presentation1.79546129
36MP0001756_abnormal_urination1.79327312
37MP0009697_abnormal_copulation1.78547981
38MP0001188_hyperpigmentation1.78087935
39MP0008004_abnormal_stomach_pH1.73545552
40MP0000015_abnormal_ear_pigmentation1.69489219
41MP0009840_abnormal_foam_cell1.68222884
42MP0004381_abnormal_hair_follicle1.67861709
43MP0010368_abnormal_lymphatic_system1.67057585
44MP0002148_abnormal_hypersensitivity_rea1.65860052
45MP0001765_abnormal_ion_homeostasis1.61464574
46MP0010094_abnormal_chromosome_stability1.57271656
47MP0003191_abnormal_cellular_cholesterol1.57058735
48MP0001800_abnormal_humoral_immune1.54835394
49MP0003943_abnormal_hepatobiliary_system1.52439478
50MP0001661_extended_life_span1.52150594
51MP0009763_increased_sensitivity_to1.50791866
52MP0000343_altered_response_to1.48188571
53MP0002398_abnormal_bone_marrow1.45922882
54MP0009780_abnormal_chondrocyte_physiolo1.44290513
55MP0003763_abnormal_thymus_physiology1.43113212
56MP0004130_abnormal_muscle_cell1.39957506
57MP0005025_abnormal_response_to1.39704561
58MP0000003_abnormal_adipose_tissue1.39260993
59MP0003806_abnormal_nucleotide_metabolis1.37228239
60MP0000465_gastrointestinal_hemorrhage1.36246908
61MP0005000_abnormal_immune_tolerance1.34136160
62MP0005075_abnormal_melanosome_morpholog1.33439474
63MP0003111_abnormal_nucleus_morphology1.32686065
64MP0005083_abnormal_biliary_tract1.30883605
65MP0009785_altered_susceptibility_to1.28791496
66MP0000703_abnormal_thymus_morphology1.28668151
67MP0002722_abnormal_immune_system1.26138277
68MP0005174_abnormal_tail_pigmentation1.25530210
69MP0004885_abnormal_endolymph1.25116784
70MP0000750_abnormal_muscle_regeneration1.23341020
71MP0003453_abnormal_keratinocyte_physiol1.22343313
72MP0003787_abnormal_imprinting1.21861862
73MP0004264_abnormal_extraembryonic_tissu1.21762413
74MP0002452_abnormal_antigen_presenting1.21149297
75MP0000689_abnormal_spleen_morphology1.20416550
76MP0002161_abnormal_fertility/fecundity1.19325526
77MP0002420_abnormal_adaptive_immunity1.17238978
78MP0002933_joint_inflammation1.14536362
79MP0008057_abnormal_DNA_replication1.13731524
80MP0002419_abnormal_innate_immunity1.13592278
81MP0001819_abnormal_immune_cell1.12951674
82MP0005058_abnormal_lysosome_morphology1.12849030
83MP0002429_abnormal_blood_cell1.11344279
84MP0005397_hematopoietic_system_phenotyp1.11185451
85MP0001545_abnormal_hematopoietic_system1.11185451
86MP0005636_abnormal_mineral_homeostasis1.10522936
87MP0000609_abnormal_liver_physiology1.10145504
88MP0002723_abnormal_immune_serum1.09990735
89MP0009333_abnormal_splenocyte_physiolog1.09611505
90MP0001533_abnormal_skeleton_physiology1.08010653
91MP0005084_abnormal_gallbladder_morpholo1.08009765
92MP0002132_abnormal_respiratory_system1.07259958
93MP0001764_abnormal_homeostasis1.06972387
94MP0004185_abnormal_adipocyte_glucose1.06761064
95MP0000716_abnormal_immune_system1.06178251
96MP0003075_altered_response_to1.06035127
97MP0005375_adipose_tissue_phenotype1.04341852
98MP0000538_abnormal_urinary_bladder1.01571744
99MP0001664_abnormal_digestion1.01387803
100MP0003091_abnormal_cell_migration1.00855306
101MP0001958_emphysema0.98738778
102MP0005647_abnormal_sex_gland0.98265706
103MP0001145_abnormal_male_reproductive0.97684546
104MP0002118_abnormal_lipid_homeostasis0.97072165
105MP0000685_abnormal_immune_system0.96541131
106MP0010155_abnormal_intestine_physiology0.96218703
107MP0008260_abnormal_autophagy0.96176573
108MP0003011_delayed_dark_adaptation0.95916448
109MP0006276_abnormal_autonomic_nervous0.95478201
110MP0002210_abnormal_sex_determination0.94298970
111MP0010386_abnormal_urinary_bladder0.94190804
112MP0003724_increased_susceptibility_to0.93462162
113MP0003195_calcinosis0.93421345
114MP0005387_immune_system_phenotype0.93245728
115MP0001790_abnormal_immune_system0.93245728
116MP0003448_altered_tumor_morphology0.90916992
117MP0009765_abnormal_xenobiotic_induced0.90544546
118MP0006036_abnormal_mitochondrial_physio0.90461359
119MP0003632_abnormal_nervous_system0.89445179
120MP0000653_abnormal_sex_gland0.89272909
121MP0009764_decreased_sensitivity_to0.89104901
122MP0000598_abnormal_liver_morphology0.86780997
123MP0002638_abnormal_pupillary_reflex0.86410248
124MP0001845_abnormal_inflammatory_respons0.86136321
125MP0000747_muscle_weakness0.85082205
126MP0003866_abnormal_defecation0.84041916
127MP0005666_abnormal_adipose_tissue0.83867494
128MP0003045_fibrosis0.82900793
129MP0008874_decreased_physiological_sensi0.82576510
130MP0005023_abnormal_wound_healing0.81968439
131MP0003879_abnormal_hair_cell0.81907965
132MP0004019_abnormal_vitamin_homeostasis0.81187442
133MP0002736_abnormal_nociception_after0.80368982
134MP0005330_cardiomyopathy0.80170856
135MP0005535_abnormal_body_temperature0.80159628
136MP0002405_respiratory_system_inflammati0.79728036
137MP0001663_abnormal_digestive_system0.79637624
138MP0003252_abnormal_bile_duct0.78592572
139MP0003279_aneurysm0.77494001
140MP0004947_skin_inflammation0.76842024
141MP0000858_altered_metastatic_potential0.76653939
142MP0009643_abnormal_urine_homeostasis0.75974262
143MP0005584_abnormal_enzyme/coenzyme_acti0.73761007
144MP0001970_abnormal_pain_threshold0.70062168
145MP0002166_altered_tumor_susceptibility0.69752132
146MP0008995_early_reproductive_senescence0.69688698
147MP0008873_increased_physiological_sensi0.67882132
148MP0005332_abnormal_amino_acid0.66638883
149MP0008469_abnormal_protein_level0.63892320
150MP0001529_abnormal_vocalization0.63624823
151MP0003122_maternal_imprinting0.63411039
152MP0006082_CNS_inflammation0.56201967

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)9.83622894
2Anterior segment dysgenesis (HP:0007700)8.64844632
3Prostate neoplasm (HP:0100787)8.18717386
4Type II lissencephaly (HP:0007260)7.85248309
5Bundle branch block (HP:0011710)7.41445035
6Buphthalmos (HP:0000557)6.30623296
7Agnosia (HP:0010524)4.71165215
8Dyschromatopsia (HP:0007641)4.64552902
9Testicular atrophy (HP:0000029)4.52514311
10Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.45363473
11Gastrointestinal stroma tumor (HP:0100723)4.41877240
12Thin bony cortex (HP:0002753)4.40907762
13Abnormality of the prostate (HP:0008775)4.38671185
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.37574218
15Ependymoma (HP:0002888)4.30124221
16Rib fusion (HP:0000902)4.27781079
17Increased neuronal autofluorescent lipopigment (HP:0002074)4.18536999
18Dynein arm defect of respiratory motile cilia (HP:0012255)4.01555396
19Absent/shortened dynein arms (HP:0200106)4.01555396
20Heart block (HP:0012722)3.87157751
21Hemorrhage of the eye (HP:0011885)3.84452444
22Capillary hemangiomas (HP:0005306)3.83704694
23Congenital glaucoma (HP:0001087)3.72445711
24Spinal rigidity (HP:0003306)3.68073004
25Medulloblastoma (HP:0002885)3.66741922
26Poikiloderma (HP:0001029)3.64703993
27Attenuation of retinal blood vessels (HP:0007843)3.63974838
28Increased cerebral lipofuscin (HP:0011813)3.61501022
29Abnormal atrioventricular conduction (HP:0005150)3.58424877
30Annular pancreas (HP:0001734)3.50195734
31Abnormality of the intrinsic pathway (HP:0010989)3.49414742
32Abnormality of mucopolysaccharide metabolism (HP:0011020)3.46935235
33Abnormality of polysaccharide metabolism (HP:0011012)3.46935235
34Abnormality of glycosaminoglycan metabolism (HP:0004371)3.46935235
35Joint stiffness (HP:0001387)3.44314126
36Petechiae (HP:0000967)3.41826049
37Joint hemorrhage (HP:0005261)3.38777156
38Hypoplasia of the brainstem (HP:0002365)3.38529492
39Aplasia/Hypoplasia of the brainstem (HP:0007362)3.38529492
40Severe muscular hypotonia (HP:0006829)3.37277353
41Abnormality of the anterior chamber (HP:0000593)3.36277457
42Intestinal fistula (HP:0100819)3.32744926
43Urinary glycosaminoglycan excretion (HP:0003541)3.32207329
44Mucopolysacchariduria (HP:0008155)3.32207329
45Rectovaginal fistula (HP:0000143)3.26908153
46Rectal fistula (HP:0100590)3.26908153
47Abnormal respiratory motile cilium physiology (HP:0012261)3.23073410
48Mesangial abnormality (HP:0001966)3.22518935
49Prolonged bleeding time (HP:0003010)3.17001311
50Facial hemangioma (HP:0000329)3.16176868
51Facial diplegia (HP:0001349)3.16115370
52Dysostosis multiplex (HP:0000943)3.12317504
53Vaginal fistula (HP:0004320)3.09750885
54Fetal akinesia sequence (HP:0001989)3.08243670
55Generalized muscle weakness (HP:0003324)3.05478674
56Gastrointestinal infarctions (HP:0005244)3.04153619
57Abnormal respiratory motile cilium morphology (HP:0005938)3.03936066
58Abnormal respiratory epithelium morphology (HP:0012253)3.03936066
59Ulnar bowing (HP:0003031)3.03738174
60Chronic bronchitis (HP:0004469)3.03394662
61Congenital stationary night blindness (HP:0007642)2.97673707
62Abnormality of the common coagulation pathway (HP:0010990)2.88242059
63Epistaxis (HP:0000421)2.87173763
64Lissencephaly (HP:0001339)2.83198820
65Anteriorly placed anus (HP:0001545)2.83042069
66Nasal polyposis (HP:0100582)2.82040302
67Turricephaly (HP:0000262)2.81902815
68Vacuolated lymphocytes (HP:0001922)2.81406969
69Decreased electroretinogram (ERG) amplitude (HP:0000654)2.80229965
70Rhinitis (HP:0012384)2.79729288
71Stomach cancer (HP:0012126)2.79539569
72Akinesia (HP:0002304)2.78249352
73Elevated erythrocyte sedimentation rate (HP:0003565)2.72756129
74Male infertility (HP:0003251)2.71165063
75Abnormality of the astrocytes (HP:0100707)2.69263655
76Astrocytoma (HP:0009592)2.69263655
77Abnormality of the pupil (HP:0000615)2.68671936
78Purpura (HP:0000979)2.66830411
79Macroglossia (HP:0000158)2.66740141
80Rhabdomyosarcoma (HP:0002859)2.66439896
81Delayed epiphyseal ossification (HP:0002663)2.65281123
82Abnormality of the vitreous humor (HP:0004327)2.64660253
83Abnormality of liposaccharide metabolism (HP:0010968)2.63964982
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.63964982
85Abnormality of glycolipid metabolism (HP:0010969)2.63964982
86Abnormality of the costochondral junction (HP:0000919)2.61077180
87Meningocele (HP:0002435)2.60272788
88Popliteal pterygium (HP:0009756)2.59931635
89Abnormality of the heme biosynthetic pathway (HP:0010472)2.55372953
90Agammaglobulinemia (HP:0004432)2.53330330
91Amaurosis fugax (HP:0100576)2.49963101
92Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.49141449
93Intellectual disability, profound (HP:0002187)2.46557806
94Abnormality of aromatic amino acid family metabolism (HP:0004338)2.45901175
95Aplasia of the musculature (HP:0100854)2.45423172
96Acute lymphatic leukemia (HP:0006721)2.43823981
97Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.43491611
98Abnormal ciliary motility (HP:0012262)2.42204382
99Neoplasm of the rectum (HP:0100743)2.40442492
100Progressive inability to walk (HP:0002505)2.35323395
101Infertility (HP:0000789)2.32635621
102Choroideremia (HP:0001139)2.31891766
103Abnormality of macrophages (HP:0004311)2.31163174
104Squamous cell carcinoma (HP:0002860)2.30544779
105Abnormality of the nasal mucosa (HP:0000433)2.29766580
106Asymmetric septal hypertrophy (HP:0001670)2.28728493
107Coronal craniosynostosis (HP:0004440)2.28535749
108Bronchitis (HP:0012387)2.26783658
109Chronic hepatic failure (HP:0100626)2.25585546
110Neonatal onset (HP:0003623)2.24777419
111Renal Fanconi syndrome (HP:0001994)2.24305906
112Abnormal platelet volume (HP:0011876)2.21267736
113Spastic tetraparesis (HP:0001285)2.19365117
114Decreased central vision (HP:0007663)2.18487089
115Poikilocytosis (HP:0004447)2.17709183
116Flat occiput (HP:0005469)2.16475991
117Glioma (HP:0009733)2.14772862
118Premature graying of hair (HP:0002216)2.12947491
119Myositis (HP:0100614)2.12196574
120Prolonged partial thromboplastin time (HP:0003645)2.09937604
121Bony spicule pigmentary retinopathy (HP:0007737)2.09471790
122Hypophosphatemic rickets (HP:0004912)2.09324660
123Atrioventricular block (HP:0001678)2.08741190
124Increased mean platelet volume (HP:0011877)2.07699060
125Abnormality of male internal genitalia (HP:0000022)2.05659052
126Neoplasm of the small intestine (HP:0100833)2.05473428
127Cheilitis (HP:0100825)2.04746342
128Enlarged epiphyses (HP:0010580)2.03946941
129Hypertriglyceridemia (HP:0002155)2.02014656
130Increased muscle lipid content (HP:0009058)2.01759741
131Cervical subluxation (HP:0003308)2.00560662
132Increased serum ferritin (HP:0003281)2.00174673
133Zonular cataract (HP:0010920)1.98392540
134Aplastic anemia (HP:0001915)1.97229711
135Bronchiectasis (HP:0002110)1.97120980
136Pachygyria (HP:0001302)1.97071272
137Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96487437
138Basal cell carcinoma (HP:0002671)1.96180298
139Menorrhagia (HP:0000132)1.96056484
140Hyperbilirubinemia (HP:0002904)1.94975319
141Inability to walk (HP:0002540)1.94700576
142Neuroblastoma (HP:0003006)1.94429428
143Primitive neuroectodermal tumor (HP:0030065)1.94429428
144Neuroblastic tumors (HP:0004376)1.94429428
145Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.94429428
146Episodic fever (HP:0001954)1.93132254
147Muscular dystrophy (HP:0003560)1.92886640
148Anomalous pulmonary venous return (HP:0010772)1.91693356
149Recurrent otitis media (HP:0000403)1.90641430
150Neoplasm of striated muscle (HP:0009728)1.90550102
151Pustule (HP:0200039)1.89873911
152Abnormality of iron homeostasis (HP:0011031)1.88838934
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.88641544
154Hepatosplenomegaly (HP:0001433)1.88187736
155Cholecystitis (HP:0001082)1.88091498
156Abnormal gallbladder physiology (HP:0012438)1.88091498
157Increased intramyocellular lipid droplets (HP:0012240)1.87466357
158Widely patent fontanelles and sutures (HP:0004492)1.87246526
159Birth length less than 3rd percentile (HP:0003561)1.86752753
160Acanthocytosis (HP:0001927)1.86538067
161Acute myeloid leukemia (HP:0004808)1.86521957
162Biliary tract neoplasm (HP:0100574)1.86370093
163Open mouth (HP:0000194)1.86198970
164Neoplasm of the peripheral nervous system (HP:0100007)1.85500200
165Reduced antithrombin III activity (HP:0001976)1.85125675
166Abnormality of placental membranes (HP:0011409)1.84191090
167Amniotic constriction ring (HP:0009775)1.84191090
168Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.83201980
169Metaphyseal irregularity (HP:0003025)1.82497750
170Easy fatigability (HP:0003388)1.82140741
171Narrow nasal bridge (HP:0000446)1.81887867
172Nonimmune hydrops fetalis (HP:0001790)1.80922520
173Orchitis (HP:0100796)1.80818197
174Myopathic facies (HP:0002058)1.79777187
175Recurrent sinusitis (HP:0011108)1.78635460
176Stomatitis (HP:0010280)1.78126571
177Abnormal platelet function (HP:0011869)1.77008764
178Impaired platelet aggregation (HP:0003540)1.77008764
179Abnormal drinking behavior (HP:0030082)1.76887090
180Polydipsia (HP:0001959)1.76887090
181Amyloidosis (HP:0011034)1.76683152
182Recurrent bronchitis (HP:0002837)1.75709655
183Polymicrogyria (HP:0002126)1.74758290
184Lymphopenia (HP:0001888)1.71796546
185Polygenic inheritance (HP:0010982)1.69651050
186Neutropenia (HP:0001875)1.65958123
187Nephronophthisis (HP:0000090)1.65743261
188Molar tooth sign on MRI (HP:0002419)1.65653643
189Abnormality of midbrain morphology (HP:0002418)1.65653643
190Neoplasm of the liver (HP:0002896)1.64221640
191Insulin-resistant diabetes mellitus (HP:0000831)1.62563829
192Retinal dysplasia (HP:0007973)1.62018819
193Abnormality of cells of the lymphoid lineage (HP:0012140)1.60951316
194Abolished electroretinogram (ERG) (HP:0000550)1.59632355
195Lymphoma (HP:0002665)1.58594987
196Intention tremor (HP:0002080)1.57286514
197Esophageal neoplasm (HP:0100751)1.55900001
198Neoplasm of head and neck (HP:0012288)1.55900001

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.64781563
2KDR4.37619475
3MAP3K104.29351091
4KIT4.01233482
5FLT33.72364204
6MAP3K142.63547214
7MAP3K112.58194202
8TESK22.50067093
9BMX2.36923355
10PDK32.28916836
11PDK42.28916836
12PIK3CA2.11549526
13PIK3CG12.8905132
14MATK1.71474929
15PDK21.66197603
16HIPK21.62603663
17MARK21.61632295
18CSF1R1.58596326
19MAP3K31.54886892
20RIPK41.51661321
21TESK11.40056749
22FES1.31938240
23BCKDK1.29415344
24CLK11.24976356
25ABL21.16643995
26MAP3K11.14241542
27IRAK31.12517723
28TAOK21.11813896
29ERN11.06777184
30PRKD31.05829050
31NME21.05606660
32ICK1.03641174
33TLK11.03057147
34MUSK1.02740151
35SCYL20.92062835
36GRK60.89214598
37MAP4K10.87537839
38SIK30.86184375
39ADRBK10.83436437
40PASK0.77918760
41PTK2B0.77604270
42MAP2K40.77363021
43IRAK40.77251011
44IRAK20.76831389
45MAPK70.75746702
46DDR20.73163378
47TGFBR20.70346860
48PRPF4B0.69409568
49TAOK30.69335916
50ARAF0.69331459
51PKN20.68120441
52CCNB10.66208385
53TAOK10.64118286
54ADRBK20.62523496
55ILK0.61963486
56FRK0.60550988
57RAF10.59751631
58CDC42BPA0.59004791
59DAPK30.57357064
60HCK0.57284224
61PAK10.56751830
62LCK0.56667162
63ACVR1B0.55608200
64MAPK150.55466052
65TYK20.55284049
66PKN10.53834560
67WNK40.51829774
68TIE10.49796544
69PDK10.49626363
70CDK11A0.48821101
71DAPK10.48678045
72SIK10.48446035
73CDK150.48191441
74STK160.47862071
75CDK60.46888819
76KSR20.46634114
77TRIB30.46607422
78PRKD20.45619103
79BRD40.44835545
80MARK30.44363764
81BTK0.44052187
82PRKG20.43463810
83PRKG10.43328191
84MAPK110.43254419
85CDK180.43070498
86PAK40.42906143
87RPS6KA50.41722920
88PIM20.40761715
89SYK0.39784774
90CDK40.39599177
91DYRK30.38902192
92PDGFRB0.38234336
93CDK190.37611037
94CHUK0.37420553
95ZAP700.36499442
96CDK140.35920129
97RPS6KC10.34281507
98RPS6KL10.34281507
99RPS6KA60.34073340
100LYN0.33457519
101RET0.31514946
102SGK20.31425801
103PIM10.30399011
104AURKA0.30329813
105CDK120.29679699
106EEF2K0.29182546
107MAP3K120.28926533
108PDPK10.27634031
109STK40.25734558
110DYRK1B0.24922603
111TXK0.24870244
112ATR0.24759693
113JAK30.24744746
114TBK10.24720553
115PRKCH0.24641108
116CHEK10.23538309
117SGK30.22592819
118RPS6KB10.21896839
119CDK80.21701675
120INSRR0.20948389
121MAP2K60.20944116
122DAPK20.20853230
123RPS6KA20.19555285
124MAPK40.19475025
125ATM0.19253448
126IKBKB0.18859743
127MAP3K60.17807984
128MAP2K30.17372346
129IKBKE0.17086553
130PRKCQ0.16415498
131JAK20.16239429
132TEC0.15543767
133MAPK30.14856928
134CSK0.13859530
135TNK20.13243232
136JAK10.12762966
137PRKD10.12674238
138IGF1R0.11993500
139SIK20.11981687
140EPHB10.11777922
141PLK10.11041446
142SGK2230.10648717
143SGK4940.10648717
144PRKCB0.10168680
145CSNK2A20.09340177
146CDK70.08945874
147MAPK120.08681615

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041224.41457201
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.05746761
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.58395629
4Carbohydrate digestion and absorption_Homo sapiens_hsa049733.45916803
5Other glycan degradation_Homo sapiens_hsa005113.35773118
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.18395306
7Acute myeloid leukemia_Homo sapiens_hsa052212.91672976
8Selenocompound metabolism_Homo sapiens_hsa004502.88343020
9Sulfur metabolism_Homo sapiens_hsa009202.77141581
10Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.51076990
11B cell receptor signaling pathway_Homo sapiens_hsa046622.41108353
12Central carbon metabolism in cancer_Homo sapiens_hsa052302.38504972
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34811349
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.30901976
15Type II diabetes mellitus_Homo sapiens_hsa049302.29933475
16Lysosome_Homo sapiens_hsa041422.12734873
17PPAR signaling pathway_Homo sapiens_hsa033202.00795897
18Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.91886532
19Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.88936140
20Mismatch repair_Homo sapiens_hsa034301.88264079
21Non-small cell lung cancer_Homo sapiens_hsa052231.86188830
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.79488948
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78631526
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.60723730
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.59707497
26Fatty acid degradation_Homo sapiens_hsa000711.55893686
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.54357131
28Pyruvate metabolism_Homo sapiens_hsa006201.52836993
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.50420842
30Ovarian steroidogenesis_Homo sapiens_hsa049131.49271854
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.46920356
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44254471
33Propanoate metabolism_Homo sapiens_hsa006401.41807426
34Staphylococcus aureus infection_Homo sapiens_hsa051501.40474123
35Sphingolipid metabolism_Homo sapiens_hsa006001.38748231
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36066447
37Leishmaniasis_Homo sapiens_hsa051401.34150057
38Histidine metabolism_Homo sapiens_hsa003401.29481658
39Vitamin B6 metabolism_Homo sapiens_hsa007501.26221546
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24132407
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23876642
42Endocytosis_Homo sapiens_hsa041441.23106168
43Malaria_Homo sapiens_hsa051441.22464551
44Non-homologous end-joining_Homo sapiens_hsa034501.20411411
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20350115
46Fanconi anemia pathway_Homo sapiens_hsa034601.19606831
47Inositol phosphate metabolism_Homo sapiens_hsa005621.16675369
48Glutathione metabolism_Homo sapiens_hsa004801.16192599
49VEGF signaling pathway_Homo sapiens_hsa043701.15670690
50ABC transporters_Homo sapiens_hsa020101.14885146
51Insulin resistance_Homo sapiens_hsa049311.13510415
52Endometrial cancer_Homo sapiens_hsa052131.13050223
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12762164
54Tuberculosis_Homo sapiens_hsa051521.11109143
55Systemic lupus erythematosus_Homo sapiens_hsa053221.10689587
56Measles_Homo sapiens_hsa051621.10644582
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09142736
58Prolactin signaling pathway_Homo sapiens_hsa049171.08775282
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07124761
60Osteoclast differentiation_Homo sapiens_hsa043801.06376480
61Glioma_Homo sapiens_hsa052141.02030924
62NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01776680
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01693430
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01308272
65Regulation of autophagy_Homo sapiens_hsa041400.99282070
66Tryptophan metabolism_Homo sapiens_hsa003800.98413170
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97688209
68beta-Alanine metabolism_Homo sapiens_hsa004100.97592934
69Folate biosynthesis_Homo sapiens_hsa007900.96204709
70T cell receptor signaling pathway_Homo sapiens_hsa046600.95970539
71Primary immunodeficiency_Homo sapiens_hsa053400.94521572
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93222665
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92730639
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91590008
75Complement and coagulation cascades_Homo sapiens_hsa046100.90655861
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90078592
77Phenylalanine metabolism_Homo sapiens_hsa003600.87387008
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87382429
79Fatty acid elongation_Homo sapiens_hsa000620.87229059
80mTOR signaling pathway_Homo sapiens_hsa041500.85200554
81Chemical carcinogenesis_Homo sapiens_hsa052040.85030460
82Toxoplasmosis_Homo sapiens_hsa051450.84287453
83Peroxisome_Homo sapiens_hsa041460.81854775
84Pancreatic cancer_Homo sapiens_hsa052120.81158013
85Pertussis_Homo sapiens_hsa051330.80851488
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.80552910
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79817513
88Salmonella infection_Homo sapiens_hsa051320.79170734
89Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79064203
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78825291
91Allograft rejection_Homo sapiens_hsa053300.78139754
92AMPK signaling pathway_Homo sapiens_hsa041520.76449606
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76222283
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.75566741
95Small cell lung cancer_Homo sapiens_hsa052220.75236955
96Glycerolipid metabolism_Homo sapiens_hsa005610.72957292
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.72402026
98Hematopoietic cell lineage_Homo sapiens_hsa046400.72037071
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71884551
100Chronic myeloid leukemia_Homo sapiens_hsa052200.71595284
101TNF signaling pathway_Homo sapiens_hsa046680.71428952
102Estrogen signaling pathway_Homo sapiens_hsa049150.69486765
103Viral carcinogenesis_Homo sapiens_hsa052030.69030849
104Fructose and mannose metabolism_Homo sapiens_hsa000510.67351815
105Fatty acid metabolism_Homo sapiens_hsa012120.66202458
106Bladder cancer_Homo sapiens_hsa052190.64925621
107Galactose metabolism_Homo sapiens_hsa000520.64505541
108Caffeine metabolism_Homo sapiens_hsa002320.63966681
109Platelet activation_Homo sapiens_hsa046110.63661423
110Prostate cancer_Homo sapiens_hsa052150.63107838
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62004396
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61900788
113Intestinal immune network for IgA production_Homo sapiens_hsa046720.61646536
114Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61550841
115Glucagon signaling pathway_Homo sapiens_hsa049220.61164319
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.60574079
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.60342085
118African trypanosomiasis_Homo sapiens_hsa051430.60182678
119Rheumatoid arthritis_Homo sapiens_hsa053230.60181730
120Phagosome_Homo sapiens_hsa041450.60180943
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58401686
122Shigellosis_Homo sapiens_hsa051310.58203194
123Fatty acid biosynthesis_Homo sapiens_hsa000610.58198563
124Tyrosine metabolism_Homo sapiens_hsa003500.57617263
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56946211
126Arginine biosynthesis_Homo sapiens_hsa002200.56403270
127Carbon metabolism_Homo sapiens_hsa012000.55339633
128Influenza A_Homo sapiens_hsa051640.54144158
129Vibrio cholerae infection_Homo sapiens_hsa051100.53957935
130Type I diabetes mellitus_Homo sapiens_hsa049400.53450864
131Chemokine signaling pathway_Homo sapiens_hsa040620.53201286
132Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53093192
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51795267
134Calcium signaling pathway_Homo sapiens_hsa040200.51177945
135Melanoma_Homo sapiens_hsa052180.50990556
136Hepatitis C_Homo sapiens_hsa051600.50270498
137Apoptosis_Homo sapiens_hsa042100.50039261
138Fat digestion and absorption_Homo sapiens_hsa049750.49447012
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.49077785
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49022647
141Autoimmune thyroid disease_Homo sapiens_hsa053200.48890704
142Graft-versus-host disease_Homo sapiens_hsa053320.47979813
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47959874
144Arachidonic acid metabolism_Homo sapiens_hsa005900.47270261
145Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46160946
146Colorectal cancer_Homo sapiens_hsa052100.44911639
147Legionellosis_Homo sapiens_hsa051340.44365860
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.43715456
149Linoleic acid metabolism_Homo sapiens_hsa005910.41786506
150Renal cell carcinoma_Homo sapiens_hsa052110.41738960
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41515919
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40889470
153Asthma_Homo sapiens_hsa053100.38254884
154Taste transduction_Homo sapiens_hsa047420.36252455
155N-Glycan biosynthesis_Homo sapiens_hsa005100.32381205
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32099460
157Collecting duct acid secretion_Homo sapiens_hsa049660.31715065
158Sphingolipid signaling pathway_Homo sapiens_hsa040710.31225080
159Vitamin digestion and absorption_Homo sapiens_hsa049770.29221481
160SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26345262
161Gap junction_Homo sapiens_hsa045400.24472797
162Renin-angiotensin system_Homo sapiens_hsa046140.22450871
163Herpes simplex infection_Homo sapiens_hsa051680.22425337
164Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.22235199
165Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20206617

Most similar genes based on co-expression Upload to Enrichr

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