LRPPRC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.98581235
2pore complex assembly (GO:0046931)5.92338898
3lysine metabolic process (GO:0006553)5.59514997
4lysine catabolic process (GO:0006554)5.59514997
5L-phenylalanine catabolic process (GO:0006559)5.25348554
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.25348554
7L-phenylalanine metabolic process (GO:0006558)5.23327245
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.23327245
9mitotic chromosome condensation (GO:0007076)5.04081278
10mitotic sister chromatid cohesion (GO:0007064)4.99590772
11glycine metabolic process (GO:0006544)4.93205865
12glyoxylate metabolic process (GO:0046487)4.76016339
13serine family amino acid catabolic process (GO:0009071)4.72789405
14kynurenine metabolic process (GO:0070189)4.52699208
15aromatic amino acid family catabolic process (GO:0009074)4.51945610
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.36974196
172-oxoglutarate metabolic process (GO:0006103)4.36850928
18urea cycle (GO:0000050)4.34144949
19urea metabolic process (GO:0019627)4.34144949
20cysteine metabolic process (GO:0006534)4.33823247
21folic acid-containing compound biosynthetic process (GO:0009396)4.29215294
22alpha-linolenic acid metabolic process (GO:0036109)4.27952176
23DNA strand elongation involved in DNA replication (GO:0006271)4.23888081
24aspartate family amino acid catabolic process (GO:0009068)4.22000228
25homocysteine metabolic process (GO:0050667)4.21752230
26dicarboxylic acid biosynthetic process (GO:0043650)4.19062123
27formation of translation preinitiation complex (GO:0001731)4.17139421
28serine family amino acid metabolic process (GO:0009069)4.12393617
29negative regulation of fatty acid biosynthetic process (GO:0045717)4.11444156
30cellular ketone body metabolic process (GO:0046950)4.09697372
31amino-acid betaine metabolic process (GO:0006577)4.08713758
32establishment of integrated proviral latency (GO:0075713)4.08231067
33DNA strand elongation (GO:0022616)4.07604462
34mitotic nuclear envelope disassembly (GO:0007077)4.07265004
35negative regulation of fibrinolysis (GO:0051918)4.04463457
36sister chromatid segregation (GO:0000819)4.00914512
37protein localization to chromosome, centromeric region (GO:0071459)3.99616707
38carnitine shuttle (GO:0006853)3.98220686
39fatty acid transmembrane transport (GO:1902001)3.98202649
40ribosome assembly (GO:0042255)3.96790015
41regulation of RNA export from nucleus (GO:0046831)3.96421816
42bile acid biosynthetic process (GO:0006699)3.94597507
43mitotic sister chromatid segregation (GO:0000070)3.93753991
44nitrogen cycle metabolic process (GO:0071941)3.92634071
45DNA replication initiation (GO:0006270)3.92373067
46serine family amino acid biosynthetic process (GO:0009070)3.90802167
47tryptophan catabolic process (GO:0006569)3.88866041
48indole-containing compound catabolic process (GO:0042436)3.88866041
49indolalkylamine catabolic process (GO:0046218)3.88866041
50fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.87378441
51membrane disassembly (GO:0030397)3.87024506
52nuclear envelope disassembly (GO:0051081)3.87024506
53alpha-amino acid catabolic process (GO:1901606)3.86331297
54acetyl-CoA metabolic process (GO:0006084)3.85745477
55DNA duplex unwinding (GO:0032508)3.85504253
56regulation of protein activation cascade (GO:2000257)3.84846646
57tricarboxylic acid cycle (GO:0006099)3.83590796
58tryptophan metabolic process (GO:0006568)3.83299821
59sulfur amino acid catabolic process (GO:0000098)3.80525096
60protein localization to kinetochore (GO:0034501)3.75266049
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.72579765
62DNA geometric change (GO:0032392)3.71224109
63double-strand break repair via nonhomologous end joining (GO:0006303)3.69036995
64non-recombinational repair (GO:0000726)3.69036995
65regulation of sister chromatid cohesion (GO:0007063)3.68865785
66DNA topological change (GO:0006265)3.68790218
67protein complex localization (GO:0031503)3.65464887
68fatty acid beta-oxidation (GO:0006635)3.63647508
69imidazole-containing compound metabolic process (GO:0052803)3.63324384
70tetrahydrofolate metabolic process (GO:0046653)3.60741145
71complement activation, alternative pathway (GO:0006957)3.60728430
72ketone body metabolic process (GO:1902224)3.60551217
73telomere maintenance via semi-conservative replication (GO:0032201)3.59908511
74regulation of fibrinolysis (GO:0051917)3.59677562
75regulation of complement activation (GO:0030449)3.58839085
76high-density lipoprotein particle remodeling (GO:0034375)3.58638363
77IMP biosynthetic process (GO:0006188)3.58553418
78regulation of triglyceride catabolic process (GO:0010896)3.58014579
79cellular protein complex localization (GO:0034629)3.57510619
80regulation of centriole replication (GO:0046599)3.57306111
81mitotic metaphase plate congression (GO:0007080)3.57222644
82cellular amino acid catabolic process (GO:0009063)3.54080857
83nuclear pore organization (GO:0006999)3.53905465
84glutamate metabolic process (GO:0006536)3.51114399
85IMP metabolic process (GO:0046040)3.50600242
86peptidyl-glutamic acid carboxylation (GO:0017187)3.49682792
87protein carboxylation (GO:0018214)3.49682792
88aromatic amino acid family metabolic process (GO:0009072)3.48894932
89fatty acid homeostasis (GO:0055089)3.48831541
90tricarboxylic acid metabolic process (GO:0072350)3.46495729
91bile acid metabolic process (GO:0008206)3.46385667
92positive regulation of fatty acid beta-oxidation (GO:0032000)3.46142157
93nuclear pore complex assembly (GO:0051292)3.45336770
94ethanol oxidation (GO:0006069)3.44000966
95tyrosine metabolic process (GO:0006570)3.43271084
96acylglycerol homeostasis (GO:0055090)3.42429891
97triglyceride homeostasis (GO:0070328)3.42429891
98phospholipid homeostasis (GO:0055091)3.42354163
99one-carbon metabolic process (GO:0006730)3.41582746
100fatty acid oxidation (GO:0019395)3.39032104
101regulation of mitotic spindle organization (GO:0060236)3.38109706
102short-chain fatty acid metabolic process (GO:0046459)3.36083508
103folic acid metabolic process (GO:0046655)3.35808368
104oxaloacetate metabolic process (GO:0006107)3.35140080
105negative regulation of cholesterol transport (GO:0032375)3.34844544
106negative regulation of sterol transport (GO:0032372)3.34844544
107positive regulation of chromosome segregation (GO:0051984)3.34469201
108regulation of fatty acid beta-oxidation (GO:0031998)3.33983423
109Golgi transport vesicle coating (GO:0048200)3.32754450
110COPI coating of Golgi vesicle (GO:0048205)3.32754450
111carnitine metabolic process (GO:0009437)3.31550098
112DNA conformation change (GO:0071103)3.29183440
113regulation of nucleobase-containing compound transport (GO:0032239)3.29038063
114lipid oxidation (GO:0034440)3.28689604
115protein export from nucleus (GO:0006611)3.28181120
116valine metabolic process (GO:0006573)3.26176193
117chromosome condensation (GO:0030261)3.25912145
118fatty acid catabolic process (GO:0009062)3.24239513
119negative regulation of fatty acid metabolic process (GO:0045922)3.24107539
120telomere maintenance via recombination (GO:0000722)3.21698741
121mitotic recombination (GO:0006312)3.19472326
122proline biosynthetic process (GO:0006561)3.19446630
123regulation of translational fidelity (GO:0006450)3.18985334
124spliceosomal tri-snRNP complex assembly (GO:0000244)3.18917603
125tRNA aminoacylation for protein translation (GO:0006418)3.17769550
126reverse cholesterol transport (GO:0043691)3.17245875
127regulation of cholesterol homeostasis (GO:2000188)3.17152627
128cellular modified amino acid catabolic process (GO:0042219)3.16512114
129plasma lipoprotein particle clearance (GO:0034381)3.16507360
130regulation of centrosome cycle (GO:0046605)3.15734929
131organic acid catabolic process (GO:0016054)3.14664247
132carboxylic acid catabolic process (GO:0046395)3.14664247
133nuclear envelope organization (GO:0006998)3.12680433
134protein-lipid complex remodeling (GO:0034368)3.10344892
135macromolecular complex remodeling (GO:0034367)3.10344892
136plasma lipoprotein particle remodeling (GO:0034369)3.10344892
137monocarboxylic acid catabolic process (GO:0072329)3.09968361
138pre-miRNA processing (GO:0031054)3.08266454
139branched-chain amino acid catabolic process (GO:0009083)3.08064631
140DNA replication checkpoint (GO:0000076)3.07611892
141heterochromatin organization (GO:0070828)3.07222286
142amino acid activation (GO:0043038)3.07195995
143tRNA aminoacylation (GO:0043039)3.07195995
144DNA synthesis involved in DNA repair (GO:0000731)3.06714550
145positive regulation of cell cycle checkpoint (GO:1901978)3.06477135
146regulation of fatty acid oxidation (GO:0046320)3.06177472
147regulation of chromosome segregation (GO:0051983)3.06019973
148metaphase plate congression (GO:0051310)3.05060533
149coenzyme catabolic process (GO:0009109)3.04324589
150L-serine metabolic process (GO:0006563)3.04213043
151regulation of centrosome duplication (GO:0010824)3.02346954
152chaperone-mediated protein complex assembly (GO:0051131)3.00466682
153dicarboxylic acid metabolic process (GO:0043648)2.99808189
154negative regulation of DNA repair (GO:0045738)2.99395439
155glutamine metabolic process (GO:0006541)2.98152622
156regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.97626320
157folic acid-containing compound metabolic process (GO:0006760)2.97357181
158regulation of translational termination (GO:0006449)2.96205534
159NADH metabolic process (GO:0006734)2.95513050
160regulation of translational elongation (GO:0006448)2.93266580
161regulation of spindle organization (GO:0090224)2.92789873
162negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.90426091
163regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.87609643
164nucleobase biosynthetic process (GO:0046112)2.85158095
165DNA packaging (GO:0006323)2.84853458
166ribosome biogenesis (GO:0042254)2.81173120
167purine nucleobase biosynthetic process (GO:0009113)2.78393396
168regulation of histone H3-K9 methylation (GO:0051570)2.77549657
169positive regulation of mitotic sister chromatid separation (GO:1901970)2.76946533
170positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.76946533
171positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.76946533
172* mRNA transport (GO:0051028)2.75417469
173establishment of viral latency (GO:0019043)2.74799812
174negative regulation of chromosome segregation (GO:0051985)2.74772368
175paraxial mesoderm development (GO:0048339)2.71300539
176regulation of DNA damage checkpoint (GO:2000001)2.71291319
177mitotic spindle checkpoint (GO:0071174)2.70005786
178RNA stabilization (GO:0043489)2.69920131
179mRNA stabilization (GO:0048255)2.69920131
180nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.67667218
181nucleobase-containing small molecule interconversion (GO:0015949)2.67432784
182regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66286643
183regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.66286643
184spindle checkpoint (GO:0031577)2.65973170
185mitochondrial DNA metabolic process (GO:0032042)2.65886837
186regulation of sister chromatid segregation (GO:0033045)2.65023379
187regulation of mitotic sister chromatid separation (GO:0010965)2.65023379
188regulation of mitotic sister chromatid segregation (GO:0033047)2.65023379
189negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.62604843
190negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.62604843
191negative regulation of mitotic sister chromatid segregation (GO:0033048)2.62604843
192negative regulation of mitotic sister chromatid separation (GO:2000816)2.62604843
193negative regulation of sister chromatid segregation (GO:0033046)2.62604843
194protein localization to chromosome (GO:0034502)2.61254417
195establishment of chromosome localization (GO:0051303)2.60244301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.28508802
2E2F7_22180533_ChIP-Seq_HELA_Human5.98466277
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.78086488
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.47254350
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.17948875
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.17732509
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.68773461
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.46385587
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.87462466
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.84518027
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.81894244
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61389272
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.61306849
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57511584
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.56383269
16* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47376975
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43569312
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34506195
19AR_21909140_ChIP-Seq_LNCAP_Human2.21104164
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19965230
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.15207119
22CLOCK_20551151_ChIP-Seq_293T_Human1.99118843
23ESR1_15608294_ChIP-ChIP_MCF-7_Human1.93886835
24DCP1A_22483619_ChIP-Seq_HELA_Human1.91919729
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89945245
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88232394
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.86198810
28HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.85928160
29ZNF263_19887448_ChIP-Seq_K562_Human1.85846057
30GATA1_22025678_ChIP-Seq_K562_Human1.83937293
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83076850
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.76465392
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69805698
34* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.67847943
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65488885
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.63681642
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.63348523
38TTF2_22483619_ChIP-Seq_HELA_Human1.61902741
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.57619352
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.55159514
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53727532
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50231764
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48721930
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47971259
45TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46924309
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45793304
47* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.41535950
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37854142
49CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37637692
50CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37380344
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.36395228
52* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33908082
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32768880
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.30511883
55CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28008851
56* ELK1_19687146_ChIP-ChIP_HELA_Human1.27507567
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.24364452
58TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23575331
59PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.23359447
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22782816
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.19803273
62MYC_22102868_ChIP-Seq_BL_Human1.19650228
63KDM5A_27292631_Chip-Seq_BREAST_Human1.19017141
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.18660516
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17788393
66SOX17_20123909_ChIP-Seq_XEN_Mouse1.17590121
67* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15804653
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15500748
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14757087
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14054441
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13036468
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.12733138
73* HNF4A_19822575_ChIP-Seq_HepG2_Human1.12712260
74* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11429903
75SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08326902
76* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06356486
77GABP_17652178_ChIP-ChIP_JURKAT_Human1.05000150
78PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01018715
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00989159
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00907173
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00271814
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.00061693
83CIITA_25753668_ChIP-Seq_RAJI_Human0.99034355
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98344499
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98310380
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96549898
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96394788
88* XRN2_22483619_ChIP-Seq_HELA_Human0.94523222
89ATF3_27146783_Chip-Seq_COLON_Human0.94106604
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93633184
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92402903
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91452289
93CHD1_26751641_Chip-Seq_LNCaP_Human0.91237407
94ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90798489
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.90293479
96VDR_23849224_ChIP-Seq_CD4+_Human0.89897819
97NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89753119
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89269285
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.88941581
100DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88891360
101TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88248044
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.87524539
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87213482
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86051835
105SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85849564
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85787293
107ETS1_20019798_ChIP-Seq_JURKAT_Human0.85734075
108TFEB_21752829_ChIP-Seq_HELA_Human0.85618806
109FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.85321891
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.85233327
111TP63_17297297_ChIP-ChIP_HaCaT_Human0.84993383
112GABP_19822575_ChIP-Seq_HepG2_Human0.84754568
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84693124
114SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83951904
115GATA6_25053715_ChIP-Seq_YYC3_Human0.83143833
116GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82673629
117KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.81324841
118GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.79930140
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79466023
120SOX2_18692474_ChIP-Seq_MESCs_Mouse0.78697250
121* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77714227
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.76283761
123SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76265293
124KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76254877
125TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76024831
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.75994511
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.75849194
128* FOXP3_21729870_ChIP-Seq_TREG_Human0.75781853
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74691065
130PKCTHETA_26484144_Chip-Seq_BREAST_Human0.74688325
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74319481
132* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.72973470
133* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.71949683

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.87627927
2MP0005360_urolithiasis5.51069266
3MP0005085_abnormal_gallbladder_physiolo4.93067971
4MP0005365_abnormal_bile_salt4.63179470
5MP0003806_abnormal_nucleotide_metabolis4.35345062
6MP0008875_abnormal_xenobiotic_pharmacok3.16366377
7MP0003252_abnormal_bile_duct3.03130217
8MP0002009_preneoplasia2.75248141
9MP0010329_abnormal_lipoprotein_level2.71722428
10MP0003705_abnormal_hypodermis_morpholog2.58988367
11MP0009840_abnormal_foam_cell2.58238387
12MP0008932_abnormal_embryonic_tissue2.45145855
13MP0002837_dystrophic_cardiac_calcinosis2.37398958
14MP0008058_abnormal_DNA_repair2.35417941
15MP0005332_abnormal_amino_acid2.25582381
16MP0003941_abnormal_skin_development2.20209888
17MP0008007_abnormal_cellular_replicative2.03413574
18MP0003195_calcinosis2.00864619
19MP0005083_abnormal_biliary_tract1.91146581
20MP0004084_abnormal_cardiac_muscle1.88959265
21MP0000609_abnormal_liver_physiology1.83695595
22MP0004130_abnormal_muscle_cell1.78652867
23MP0003646_muscle_fatigue1.72817008
24MP0002269_muscular_atrophy1.71220406
25MP0001666_abnormal_nutrient_absorption1.71133295
26MP0010352_gastrointestinal_tract_polyps1.68095896
27MP0005330_cardiomyopathy1.59468055
28MP0002118_abnormal_lipid_homeostasis1.59449165
29MP0005451_abnormal_body_composition1.59438189
30MP0003123_paternal_imprinting1.54069939
31MP0002396_abnormal_hematopoietic_system1.53779602
32MP0006036_abnormal_mitochondrial_physio1.51892560
33MP0005319_abnormal_enzyme/_coenzyme1.50704296
34MP0004019_abnormal_vitamin_homeostasis1.49282969
35MP0000537_abnormal_urethra_morphology1.47293529
36MP0004215_abnormal_myocardial_fiber1.46542812
37MP0001730_embryonic_growth_arrest1.42464613
38MP0005666_abnormal_adipose_tissue1.42026627
39MP0002085_abnormal_embryonic_tissue1.40429441
40MP0003191_abnormal_cellular_cholesterol1.36687485
41MP0005670_abnormal_white_adipose1.35391304
42MP0009672_abnormal_birth_weight1.33907681
43MP0003221_abnormal_cardiomyocyte_apopto1.33736928
44MP0003868_abnormal_feces_composition1.33722615
45MP0002697_abnormal_eye_size1.31695291
46MP0005266_abnormal_metabolism1.31340385
47MP0003111_abnormal_nucleus_morphology1.28267805
48MP0004233_abnormal_muscle_weight1.25982046
49MP0004957_abnormal_blastocyst_morpholog1.24753951
50MP0010094_abnormal_chromosome_stability1.24722187
51MP0009697_abnormal_copulation1.22403204
52MP0004185_abnormal_adipocyte_glucose1.21174993
53MP0004036_abnormal_muscle_relaxation1.20143206
54MP0000747_muscle_weakness1.18897844
55MP0004087_abnormal_muscle_fiber1.18868331
56MP0010307_abnormal_tumor_latency1.16902719
57MP0004264_abnormal_extraembryonic_tissu1.16401028
58MP0003693_abnormal_embryo_hatching1.15983028
59MP0003567_abnormal_fetal_cardiomyocyte1.15801932
60MP0010630_abnormal_cardiac_muscle1.15008622
61MP0010234_abnormal_vibrissa_follicle1.14897137
62MP0000313_abnormal_cell_death1.14265442
63MP0000751_myopathy1.13892657
64MP0001764_abnormal_homeostasis1.13281390
65MP0000598_abnormal_liver_morphology1.12097585
66MP0001672_abnormal_embryogenesis/_devel1.11084174
67MP0005380_embryogenesis_phenotype1.11084174
68MP0002088_abnormal_embryonic_growth/wei1.10912516
69MP0003984_embryonic_growth_retardation1.10722714
70MP0004197_abnormal_fetal_growth/weight/1.10533182
71MP0002078_abnormal_glucose_homeostasis1.09299456
72MP0004808_abnormal_hematopoietic_stem1.09174097
73MP0002796_impaired_skin_barrier1.08567305
74MP0003937_abnormal_limbs/digits/tail_de1.07636544
75MP0006035_abnormal_mitochondrial_morpho1.07503819
76MP0008775_abnormal_heart_ventricle1.07010041
77MP0001915_intracranial_hemorrhage1.06565769
78MP0003315_abnormal_perineum_morphology1.01490408
79MP0005501_abnormal_skin_physiology1.00315774
80MP0002086_abnormal_extraembryonic_tissu0.99472891
81MP0005584_abnormal_enzyme/coenzyme_acti0.99192486
82MP0009643_abnormal_urine_homeostasis0.98440141
83MP0004043_abnormal_pH_regulation0.97562883
84MP0005375_adipose_tissue_phenotype0.97440492
85MP0002166_altered_tumor_susceptibility0.97276082
86MP0003718_maternal_effect0.97134156
87MP0003077_abnormal_cell_cycle0.95519124
88MP0003786_premature_aging0.95270416
89MP0002971_abnormal_brown_adipose0.93239160
90MP0003385_abnormal_body_wall0.89432041
91MP0000003_abnormal_adipose_tissue0.88946033
92MP0000749_muscle_degeneration0.87762251
93MP0001697_abnormal_embryo_size0.87584395
94MP0002006_tumorigenesis0.87354622
95MP0010678_abnormal_skin_adnexa0.87250860
96MP0008057_abnormal_DNA_replication0.87018509
97MP0001661_extended_life_span0.86941197
98MP0002138_abnormal_hepatobiliary_system0.86918683
99MP0000428_abnormal_craniofacial_morphol0.86530378
100MP0005384_cellular_phenotype0.86292876
101MP0005621_abnormal_cell_physiology0.86031998
102MP0000579_abnormal_nail_morphology0.85858239
103MP0002092_abnormal_eye_morphology0.84858427
104MP0001544_abnormal_cardiovascular_syste0.84836523
105MP0005385_cardiovascular_system_phenoty0.84836523
106MP0005187_abnormal_penis_morphology0.84207097
107MP0002084_abnormal_developmental_patter0.83769445
108MP0005408_hypopigmentation0.82793703
109MP0009703_decreased_birth_body0.82680861
110MP0002080_prenatal_lethality0.82435074
111MP0003115_abnormal_respiratory_system0.80942987
112MP0001346_abnormal_lacrimal_gland0.80165643
113MP0003943_abnormal_hepatobiliary_system0.78507052
114MP0005220_abnormal_exocrine_pancreas0.77941036
115MP0004782_abnormal_surfactant_physiolog0.77724469
116MP0009053_abnormal_anal_canal0.76342345
117MP0000013_abnormal_adipose_tissue0.75764883
118MP0000733_abnormal_muscle_development0.75725627
119MP0001293_anophthalmia0.75272377
120MP0003656_abnormal_erythrocyte_physiolo0.74928982
121MP0000490_abnormal_crypts_of0.74724932
122MP0004272_abnormal_basement_membrane0.74319075
123MP0005076_abnormal_cell_differentiation0.73916079
124MP0002111_abnormal_tail_morphology0.73629825
125MP0000759_abnormal_skeletal_muscle0.73346852
126MP0000627_abnormal_mammary_gland0.72906433
127MP0002970_abnormal_white_adipose0.72406749
128MP0006138_congestive_heart_failure0.72388601
129MP0002972_abnormal_cardiac_muscle0.72056169
130MP0003890_abnormal_embryonic-extraembry0.71893905
131MP0005376_homeostasis/metabolism_phenot0.71754604
132MP0001849_ear_inflammation0.71551581
133MP0001756_abnormal_urination0.70665619
134MP0001286_abnormal_eye_development0.70343974
135MP0005334_abnormal_fat_pad0.69549389
136MP0000377_abnormal_hair_follicle0.68639451
137MP0000566_synostosis0.68438229
138MP0002877_abnormal_melanocyte_morpholog0.68228675
139MP0003935_abnormal_craniofacial_develop0.68184905
140MP0002019_abnormal_tumor_incidence0.68100401
141MP0000266_abnormal_heart_morphology0.67081954
142MP0003566_abnormal_cell_adhesion0.66819019
143MP0000762_abnormal_tongue_morphology0.65548167
144MP0003186_abnormal_redox_activity0.65007164
145MP0000358_abnormal_cell_content/0.65002847
146MP0002106_abnormal_muscle_physiology0.64528064
147MP0000350_abnormal_cell_proliferation0.64365120
148MP0002060_abnormal_skin_morphology0.63685780
149MP0005623_abnormal_meninges_morphology0.63536799
150MP0001348_abnormal_lacrimal_gland0.61796034

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.32064693
2Intrahepatic cholestasis (HP:0001406)5.26444143
3Hypobetalipoproteinemia (HP:0003563)4.83193419
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.71016373
5Deep venous thrombosis (HP:0002625)4.66938366
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.60225198
7Xanthomatosis (HP:0000991)4.51370423
8Chromosomal breakage induced by crosslinking agents (HP:0003221)4.50786478
9Chromsome breakage (HP:0040012)4.44116074
10Hyperammonemia (HP:0001987)4.34525375
11Ketosis (HP:0001946)4.21711445
12Hyperglycinemia (HP:0002154)4.15599906
13Hyperglycinuria (HP:0003108)4.14031959
14Hypolipoproteinemia (HP:0010981)4.08381342
15Ketoacidosis (HP:0001993)3.92018968
16Abnormality of glycine metabolism (HP:0010895)3.91424281
17Abnormality of serine family amino acid metabolism (HP:0010894)3.91424281
18Hypoalphalipoproteinemia (HP:0003233)3.79397301
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.61784704
20Hyperlipoproteinemia (HP:0010980)3.59609019
21Myoglobinuria (HP:0002913)3.58525247
22Hyperinsulinemic hypoglycemia (HP:0000825)3.51749799
23Abnormality of sulfur amino acid metabolism (HP:0004339)3.35202426
24Abnormality of fatty-acid metabolism (HP:0004359)3.31632939
25Epidermoid cyst (HP:0200040)3.30855389
26Hypoglycemic seizures (HP:0002173)3.24182809
27Prolonged partial thromboplastin time (HP:0003645)3.20250758
28Increased nuchal translucency (HP:0010880)3.18649093
29Complement deficiency (HP:0004431)3.17835406
30Abnormality of pyrimidine metabolism (HP:0004353)3.13811174
31Abnormality of methionine metabolism (HP:0010901)3.12744449
32Abnormality of aspartate family amino acid metabolism (HP:0010899)3.12061775
33Abnormality of serum amino acid levels (HP:0003112)3.07923781
34Termporal pattern (HP:0011008)2.97879044
35Insidious onset (HP:0003587)2.97879044
36Abnormality of glutamine family amino acid metabolism (HP:0010902)2.96656146
37Rhabdomyolysis (HP:0003201)2.94119793
38Nephroblastoma (Wilms tumor) (HP:0002667)2.93666715
39Progressive external ophthalmoplegia (HP:0000590)2.91296831
40Dicarboxylic aciduria (HP:0003215)2.89389411
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.89389411
42Progressive muscle weakness (HP:0003323)2.89283959
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.84771859
44Asymmetry of the thorax (HP:0001555)2.82525182
45Abnormality of glycolysis (HP:0004366)2.78910830
46Spastic diplegia (HP:0001264)2.74612357
47Embryonal renal neoplasm (HP:0011794)2.71479108
48Abnormality of the common coagulation pathway (HP:0010990)2.67967682
49Skin nodule (HP:0200036)2.67415702
50Dysmetric saccades (HP:0000641)2.66251519
51Ankyloglossia (HP:0010296)2.62108082
52Overlapping toe (HP:0001845)2.60597244
53Multiple enchondromatosis (HP:0005701)2.58265266
54* Hyperglycemia (HP:0003074)2.57227472
55Hepatocellular carcinoma (HP:0001402)2.56998848
56Exercise-induced muscle cramps (HP:0003710)2.55876378
57Ependymoma (HP:0002888)2.54132831
58Metabolic acidosis (HP:0001942)2.53350197
59Fat malabsorption (HP:0002630)2.51792882
60Pancreatic islet-cell hyperplasia (HP:0004510)2.49874670
61Abnormality of the intrinsic pathway (HP:0010989)2.47536397
62Cortical dysplasia (HP:0002539)2.47533968
63Hypochromic microcytic anemia (HP:0004840)2.46766008
64Abnormality of nucleobase metabolism (HP:0010932)2.41876497
65Gout (HP:0001997)2.39349015
66Hypercholesterolemia (HP:0003124)2.38210635
67Insomnia (HP:0100785)2.38112847
68Hyperbilirubinemia (HP:0002904)2.37826144
69Increased serum pyruvate (HP:0003542)2.37658791
70Abnormality of the pancreatic islet cells (HP:0006476)2.33969683
71Abnormality of endocrine pancreas physiology (HP:0012093)2.33969683
72Deviation of the thumb (HP:0009603)2.32846844
73Cerebral edema (HP:0002181)2.30787458
74Papillary thyroid carcinoma (HP:0002895)2.27560613
75Abnormality of chromosome stability (HP:0003220)2.26650783
76Hyperacusis (HP:0010780)2.25480236
77Abnormality of the lower motor neuron (HP:0002366)2.25169482
78Abnormality of complement system (HP:0005339)2.23788940
79Delayed CNS myelination (HP:0002188)2.22113367
80Lethargy (HP:0001254)2.21936979
81Proximal placement of thumb (HP:0009623)2.21840327
82Deep philtrum (HP:0002002)2.21262095
83Abnormality of the preputium (HP:0100587)2.17821879
84Proximal tubulopathy (HP:0000114)2.17749457
85Sudden death (HP:0001699)2.16492728
86Global brain atrophy (HP:0002283)2.16407974
87Ragged-red muscle fibers (HP:0003200)2.16277826
88Late onset (HP:0003584)2.15949109
89Joint hemorrhage (HP:0005261)2.12806434
90Missing ribs (HP:0000921)2.12216916
91Back pain (HP:0003418)2.12040134
92Acanthocytosis (HP:0001927)2.07806545
93Birth length less than 3rd percentile (HP:0003561)2.07381489
94Selective tooth agenesis (HP:0001592)2.06657645
95Abnormality of purine metabolism (HP:0004352)2.05909159
96Cholelithiasis (HP:0001081)2.04987198
97Microglossia (HP:0000171)2.04713415
98Relative macrocephaly (HP:0004482)2.04252498
99Abnormal gallbladder morphology (HP:0012437)2.03436656
100Medulloblastoma (HP:0002885)2.02293953
101Abnormality of oral frenula (HP:0000190)2.00773927
102Cafe-au-lait spot (HP:0000957)2.00729541
103Meckel diverticulum (HP:0002245)2.00601626
104Malignant gastrointestinal tract tumors (HP:0006749)1.99021589
105Gastrointestinal carcinoma (HP:0002672)1.99021589
106Generalized aminoaciduria (HP:0002909)1.98830086
107Adenoma sebaceum (HP:0009720)1.98087759
108Angiofibromas (HP:0010615)1.98087759
109Nausea (HP:0002018)1.97134052
110Conjugated hyperbilirubinemia (HP:0002908)1.95806948
111Uterine leiomyosarcoma (HP:0002891)1.95483843
112Leiomyosarcoma (HP:0100243)1.95483843
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94906960
114Embryonal neoplasm (HP:0002898)1.93291376
115Palpitations (HP:0001962)1.93187340
116Symptomatic seizures (HP:0011145)1.92604971
117Reticulocytosis (HP:0001923)1.92481648
118Exercise-induced myalgia (HP:0003738)1.91506157
119Heterotopia (HP:0002282)1.91069346
120Flat acetabular roof (HP:0003180)1.90118129
121Neonatal onset (HP:0003623)1.89958961
122Right ventricular cardiomyopathy (HP:0011663)1.89466784
123Biliary tract neoplasm (HP:0100574)1.88900046
124Abnormality of the astrocytes (HP:0100707)1.87280391
125Astrocytoma (HP:0009592)1.87280391
126Abnormality of the Achilles tendon (HP:0005109)1.87072717
127Myelodysplasia (HP:0002863)1.85780419
128Abnormality of the calcaneus (HP:0008364)1.84700365
129Abnormal cartilage morphology (HP:0002763)1.84280132
130Abnormality of the ileum (HP:0001549)1.83871484
131Sandal gap (HP:0001852)1.82131395
132Septate vagina (HP:0001153)1.80750415
133Shoulder girdle muscle weakness (HP:0003547)1.79909036
134Increased connective tissue (HP:0009025)1.79725926
135Abnormality of the salivary glands (HP:0010286)1.79071386
136Increased purine levels (HP:0004368)1.78453889
137Hyperuricemia (HP:0002149)1.78453889
138Hyporeflexia of lower limbs (HP:0002600)1.78344225
139Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.78285463
140Abnormality of vitamin metabolism (HP:0100508)1.77999750
141Subaortic stenosis (HP:0001682)1.77873734
142Abnormality of the left ventricular outflow tract (HP:0011103)1.77873734
143Acute myeloid leukemia (HP:0004808)1.77866683
144Renal cortical cysts (HP:0000803)1.77198795
145Limb hypertonia (HP:0002509)1.77165778
146Pseudobulbar signs (HP:0002200)1.76815946
147Poikilocytosis (HP:0004447)1.76271593
148Myocardial infarction (HP:0001658)1.75356877
149Overriding aorta (HP:0002623)1.74983700
150Irritability (HP:0000737)1.74780652
151Centrally nucleated skeletal muscle fibers (HP:0003687)1.73888523
152Lymphangioma (HP:0100764)1.73282100
153Neoplasm of the small intestine (HP:0100833)1.72329289
154Rhabdomyosarcoma (HP:0002859)1.71426222
155Resting tremor (HP:0002322)1.70790421
156Neoplasm of the rectum (HP:0100743)1.70472202
157Orthostatic hypotension (HP:0001278)1.70281043
158Abnormality of pain sensation (HP:0010832)1.68422190
159Impaired pain sensation (HP:0007328)1.68422190
160Primitive neuroectodermal tumor (HP:0030065)1.67222681
161Neuroblastic tumors (HP:0004376)1.67222681
162Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.67222681
163Neuroblastoma (HP:0003006)1.67222681
164Reticulocytopenia (HP:0001896)1.65939235
165Uterine neoplasm (HP:0010784)1.65297290
166Abnormality of chromosome segregation (HP:0002916)1.64684895
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.63284739
168Small intestinal stenosis (HP:0012848)1.62915824
169Duodenal stenosis (HP:0100867)1.62915824
170Abnormality of the carotid arteries (HP:0005344)1.62517807
171Abnormal foot bone ossification (HP:0010675)1.62362895
172Trismus (HP:0000211)1.61989752
173Skull defect (HP:0001362)1.61613463
174Obsessive-compulsive behavior (HP:0000722)1.61473606
175Volvulus (HP:0002580)1.60500978
176Thyroid carcinoma (HP:0002890)1.59946767
177Renal duplication (HP:0000075)1.59708966
178Choanal atresia (HP:0000453)1.59529051
179Breech presentation (HP:0001623)1.59275610
180Abnormality of reticulocytes (HP:0004312)1.58109287
181Neoplasm of the colon (HP:0100273)1.57432436
182Transitional cell carcinoma of the bladder (HP:0006740)1.57353949
183Nemaline bodies (HP:0003798)1.57328231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.98913530
2NEK13.80417201
3BCKDK3.52595212
4CDK122.93324028
5PBK2.71226632
6PDK42.65223230
7PDK32.65223230
8CDC72.59773833
9TRIB32.56338316
10TTN2.42894923
11SCYL22.39806493
12SMG12.35193662
13EPHA22.23144726
14MST1R1.95976405
15EIF2AK31.95837293
16SIK11.90261354
17FLT31.89719492
18WNK31.88485386
19TTK1.83191711
20EEF2K1.78724396
21LATS11.78228872
22WEE11.71221308
23MAP3K101.57517882
24NEK21.54417456
25MKNK11.47067899
26INSRR1.44009496
27PLK41.43204112
28FGFR41.39921831
29CAMK1D1.39860223
30MTOR1.31945068
31TSSK61.30732964
32ERBB41.28037864
33CDK41.26684464
34PDK21.18199847
35PASK1.16287254
36OBSCN1.15854360
37PDGFRA1.14424600
38TAF11.13062087
39LMTK21.11933048
40ALK1.07933849
41BRD41.06882767
42MAPK111.05830097
43ZAK1.03849028
44RPS6KB21.01225058
45MAP2K41.00828937
46FRK1.00690798
47NME21.00049026
48CDK60.97745222
49RIPK10.96374797
50STK38L0.94545781
51PTK60.88677704
52STK390.88368992
53MAP3K80.87178299
54MAP2K30.87056497
55LATS20.87003435
56PAK40.85110510
57EIF2AK10.83683193
58ACVR1B0.83123005
59CHEK10.82965751
60MKNK20.82004697
61PRKAA10.81174981
62EIF2AK20.79019935
63ATR0.78707814
64STK40.78456332
65NEK90.78434738
66PLK10.77641540
67SRPK10.75622446
68AURKB0.75068851
69CSNK1E0.74549978
70ATM0.74395878
71FGFR30.73579602
72PNCK0.72420066
73STK30.72177873
74FGFR10.69599986
75BRSK20.69484783
76PHKG20.68870971
77PHKG10.68870971
78RPS6KA40.68433225
79ICK0.67951476
80CHEK20.66530913
81MAP3K50.65583353
82PLK30.64850010
83KSR20.63802370
84BRAF0.63639832
85CAMK1G0.62645354
86STK240.62475193
87BUB10.62147966
88RET0.61962510
89PRKAA20.61587219
90CLK10.59871044
91ERN10.58820513
92MST40.58203715
93MET0.58178371
94CDK20.58102819
95CSNK1D0.58087027
96NEK60.56988789
97AKT20.56424058
98RAF10.56281470
99IRAK30.55413906
100PINK10.54126381
101WNK40.52996646
102CDK80.52888809
103MAP3K90.52058493
104MAP3K70.51284146
105CCNB10.50684038
106KSR10.48887505
107PRKDC0.48468556
108SGK30.48107415
109PIK3CG0.47967373
110MAPKAPK30.46327912
111PAK30.46065324
112RPS6KB10.45545196
113AKT30.44611035
114MAPK100.43935333
115BCR0.43461797
116MELK0.43152781
117CSNK2A20.42795913
118ERBB30.42064950
119MAP3K20.41792113
120CDK70.41051310
121CDK10.40424743
122JAK20.40268347
123PAK20.39769257
124PRPF4B0.39496726
125YES10.39386276
126NME10.39232618
127WNK10.38664211
128FGFR20.38185942
129CDK90.37232895
130BRSK10.36977546
131AURKA0.35531399
132MAP3K40.34835235
133PRKACG0.34182182
134RPS6KA30.30548586
135STK380.28847994

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.86588264
2Nitrogen metabolism_Homo sapiens_hsa009103.61526850
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.21122593
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.06485272
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.05067595
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95901021
7Fatty acid degradation_Homo sapiens_hsa000712.90224816
8Arginine biosynthesis_Homo sapiens_hsa002202.81598636
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74621637
10Propanoate metabolism_Homo sapiens_hsa006402.60171888
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.48107187
12Tryptophan metabolism_Homo sapiens_hsa003802.34405406
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30567869
14Butanoate metabolism_Homo sapiens_hsa006502.25508784
15Carbon metabolism_Homo sapiens_hsa012002.14562391
16Fatty acid metabolism_Homo sapiens_hsa012122.11720374
17Selenocompound metabolism_Homo sapiens_hsa004502.04066744
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.00289061
19One carbon pool by folate_Homo sapiens_hsa006701.98462176
20Biosynthesis of amino acids_Homo sapiens_hsa012301.91959149
21Pyruvate metabolism_Homo sapiens_hsa006201.88424179
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88149251
23Base excision repair_Homo sapiens_hsa034101.75055751
24Complement and coagulation cascades_Homo sapiens_hsa046101.68142665
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.63463816
26PPAR signaling pathway_Homo sapiens_hsa033201.60767365
27Thyroid cancer_Homo sapiens_hsa052161.59201461
28Peroxisome_Homo sapiens_hsa041461.53667551
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.50714604
30beta-Alanine metabolism_Homo sapiens_hsa004101.45561260
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43586560
32Lysine degradation_Homo sapiens_hsa003101.41820339
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36486503
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.34688672
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33435645
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33262487
37Fanconi anemia pathway_Homo sapiens_hsa034601.33137054
38Phenylalanine metabolism_Homo sapiens_hsa003601.28566415
39Caffeine metabolism_Homo sapiens_hsa002321.24499601
40Starch and sucrose metabolism_Homo sapiens_hsa005001.21517403
41Bile secretion_Homo sapiens_hsa049761.21118268
42Homologous recombination_Homo sapiens_hsa034401.20828329
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.19486450
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.16304995
45Fat digestion and absorption_Homo sapiens_hsa049751.10146574
46Tyrosine metabolism_Homo sapiens_hsa003501.09017220
47Adherens junction_Homo sapiens_hsa045201.08065093
48Oocyte meiosis_Homo sapiens_hsa041141.04630076
49Chronic myeloid leukemia_Homo sapiens_hsa052201.03797136
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01238493
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95935150
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.93753999
53Folate biosynthesis_Homo sapiens_hsa007900.93648831
54Chemical carcinogenesis_Homo sapiens_hsa052040.93372735
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92044723
56Histidine metabolism_Homo sapiens_hsa003400.91306279
57MicroRNAs in cancer_Homo sapiens_hsa052060.89075545
58Arginine and proline metabolism_Homo sapiens_hsa003300.86165813
59ABC transporters_Homo sapiens_hsa020100.86131730
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85869738
61Basal transcription factors_Homo sapiens_hsa030220.84998930
62Retinol metabolism_Homo sapiens_hsa008300.84538130
63N-Glycan biosynthesis_Homo sapiens_hsa005100.83170870
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.83054301
65Fatty acid elongation_Homo sapiens_hsa000620.80096695
66Small cell lung cancer_Homo sapiens_hsa052220.78763029
67Vitamin B6 metabolism_Homo sapiens_hsa007500.78070672
68Non-small cell lung cancer_Homo sapiens_hsa052230.77387785
69p53 signaling pathway_Homo sapiens_hsa041150.76214314
70Pentose phosphate pathway_Homo sapiens_hsa000300.75583385
71Pancreatic cancer_Homo sapiens_hsa052120.73078032
72Glucagon signaling pathway_Homo sapiens_hsa049220.71064286
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70341616
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70101824
75Endometrial cancer_Homo sapiens_hsa052130.70035596
76Sulfur metabolism_Homo sapiens_hsa009200.69682841
77Purine metabolism_Homo sapiens_hsa002300.69048409
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68726932
79Fatty acid biosynthesis_Homo sapiens_hsa000610.66963446
80Colorectal cancer_Homo sapiens_hsa052100.66800760
81Ribosome_Homo sapiens_hsa030100.65578746
82RNA transport_Homo sapiens_hsa030130.65213733
83Proteasome_Homo sapiens_hsa030500.64140358
84Systemic lupus erythematosus_Homo sapiens_hsa053220.63308210
85Hippo signaling pathway_Homo sapiens_hsa043900.63273126
86Bladder cancer_Homo sapiens_hsa052190.63176480
87RNA polymerase_Homo sapiens_hsa030200.61994221
88Insulin resistance_Homo sapiens_hsa049310.60863892
89Fructose and mannose metabolism_Homo sapiens_hsa000510.60114243
90Prostate cancer_Homo sapiens_hsa052150.58018096
91Glycerolipid metabolism_Homo sapiens_hsa005610.57318648
92Glioma_Homo sapiens_hsa052140.56667942
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56186014
94Staphylococcus aureus infection_Homo sapiens_hsa051500.54290320
95Alcoholism_Homo sapiens_hsa050340.54016609
96Sulfur relay system_Homo sapiens_hsa041220.53364187
97Galactose metabolism_Homo sapiens_hsa000520.53350364
98Proteoglycans in cancer_Homo sapiens_hsa052050.51683132
99AMPK signaling pathway_Homo sapiens_hsa041520.50822784
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.49721939
101Mismatch repair_Homo sapiens_hsa034300.49103759
102ErbB signaling pathway_Homo sapiens_hsa040120.48320597
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47843083
104Tight junction_Homo sapiens_hsa045300.45170776
105DNA replication_Homo sapiens_hsa030300.43363038
106Insulin signaling pathway_Homo sapiens_hsa049100.43000814
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42692902
108Inositol phosphate metabolism_Homo sapiens_hsa005620.41201844
109Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40988424
110TGF-beta signaling pathway_Homo sapiens_hsa043500.40855024
111Vitamin digestion and absorption_Homo sapiens_hsa049770.40095656
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39915186
113Wnt signaling pathway_Homo sapiens_hsa043100.39393415
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38661153
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.38023773
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37822864
117Metabolic pathways_Homo sapiens_hsa011000.37269613
118Renal cell carcinoma_Homo sapiens_hsa052110.37234149
119Glutathione metabolism_Homo sapiens_hsa004800.33952842
120mTOR signaling pathway_Homo sapiens_hsa041500.32354280
121Thyroid hormone synthesis_Homo sapiens_hsa049180.31428470
122HIF-1 signaling pathway_Homo sapiens_hsa040660.28353142
123HTLV-I infection_Homo sapiens_hsa051660.27819676
124Prion diseases_Homo sapiens_hsa050200.26988572
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.23821648
126mRNA surveillance pathway_Homo sapiens_hsa030150.23133917
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22776667
128Type II diabetes mellitus_Homo sapiens_hsa049300.21042844
129Cell cycle_Homo sapiens_hsa041100.19232254
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17953573
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.10123398
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.06737825
133RNA degradation_Homo sapiens_hsa030180.06016391
134Dilated cardiomyopathy_Homo sapiens_hsa054140.05830397
135Steroid biosynthesis_Homo sapiens_hsa001000.05732737
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.05626275
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.05368624
138Viral carcinogenesis_Homo sapiens_hsa052030.04199348
139Spliceosome_Homo sapiens_hsa030400.03980260
140Pyrimidine metabolism_Homo sapiens_hsa002400.01516616
141Nucleotide excision repair_Homo sapiens_hsa034200.01101854
142Non-homologous end-joining_Homo sapiens_hsa03450-0.0131208

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