LRP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of fatty acid beta-oxidation (GO:0032000)4.25921506
2nuclear pore complex assembly (GO:0051292)3.78263234
3insulin-like growth factor receptor signaling pathway (GO:0048009)3.66725569
4mitotic sister chromatid cohesion (GO:0007064)3.45742016
5nuclear pore organization (GO:0006999)3.35392403
6notochord development (GO:0030903)3.33937023
7positive regulation of fatty acid oxidation (GO:0046321)3.30877313
8protein heterotrimerization (GO:0070208)3.30175117
9regulation of fatty acid beta-oxidation (GO:0031998)3.21800064
10sulfur amino acid catabolic process (GO:0000098)3.18814719
11pre-miRNA processing (GO:0031054)3.14334041
12collagen fibril organization (GO:0030199)3.12754100
13regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.11746956
14alpha-linolenic acid metabolic process (GO:0036109)3.09568555
15protein carboxylation (GO:0018214)3.07676797
16peptidyl-glutamic acid carboxylation (GO:0017187)3.07676797
17midgut development (GO:0007494)3.02351513
18mesenchymal-epithelial cell signaling (GO:0060638)3.01567079
19fatty acid transmembrane transport (GO:1902001)3.00194461
20negative regulation of chondrocyte differentiation (GO:0032331)2.95278182
21* embryonic retina morphogenesis in camera-type eye (GO:0060059)2.95002902
22presynaptic membrane assembly (GO:0097105)2.93996056
23homocysteine metabolic process (GO:0050667)2.91937931
24apoptotic cell clearance (GO:0043277)2.87262591
25carnitine shuttle (GO:0006853)2.86678175
26hippo signaling (GO:0035329)2.84795914
27growth hormone receptor signaling pathway (GO:0060396)2.84664772
28paraxial mesoderm development (GO:0048339)2.83588829
29embryonic foregut morphogenesis (GO:0048617)2.81304249
30regulation of cholesterol homeostasis (GO:2000188)2.81264357
31planar cell polarity pathway involved in neural tube closure (GO:0090179)2.78758179
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.78645307
33embryonic placenta development (GO:0001892)2.76239631
34regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.73135225
35regulation of posttranscriptional gene silencing (GO:0060147)2.73052969
36regulation of gene silencing by miRNA (GO:0060964)2.73052969
37regulation of gene silencing by RNA (GO:0060966)2.73052969
38* dorsal/ventral axis specification (GO:0009950)2.71866555
39negative regulation of fatty acid biosynthetic process (GO:0045717)2.71798277
40embryonic process involved in female pregnancy (GO:0060136)2.70943648
41L-phenylalanine catabolic process (GO:0006559)2.65554662
42erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65554662
43L-phenylalanine metabolic process (GO:0006558)2.64013958
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.64013958
45urea cycle (GO:0000050)2.63976385
46urea metabolic process (GO:0019627)2.63976385
47negative regulation of translation, ncRNA-mediated (GO:0040033)2.62138975
48regulation of translation, ncRNA-mediated (GO:0045974)2.62138975
49negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.62138975
50establishment of apical/basal cell polarity (GO:0035089)2.61573643
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.60442810
52positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.60237430
53pore complex assembly (GO:0046931)2.58736379
54cytoplasmic mRNA processing body assembly (GO:0033962)2.58477540
55regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.58066638
56lateral sprouting from an epithelium (GO:0060601)2.57165897
57regulation of centriole replication (GO:0046599)2.57016184
58complement activation, alternative pathway (GO:0006957)2.56600202
59positive regulation of lipid catabolic process (GO:0050996)2.56343997
60phospholipid homeostasis (GO:0055091)2.55237736
61basement membrane organization (GO:0071711)2.55138416
62glyoxylate metabolic process (GO:0046487)2.54830832
63negative regulation of cartilage development (GO:0061037)2.54293690
64regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.51368896
65lysine metabolic process (GO:0006553)2.50698368
66lysine catabolic process (GO:0006554)2.50698368
67protein localization to kinetochore (GO:0034501)2.50512000
68regulation of protein activation cascade (GO:2000257)2.50226995
69anatomical structure regression (GO:0060033)2.48053096
70epoxygenase P450 pathway (GO:0019373)2.47964376
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.47738159
72retina vasculature morphogenesis in camera-type eye (GO:0061299)2.46064410
73fatty acid beta-oxidation (GO:0006635)2.45759751
74glomerular basement membrane development (GO:0032836)2.45750286
75cellular response to growth hormone stimulus (GO:0071378)2.44553335
76mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.44464895
77limb bud formation (GO:0060174)2.44255995
78presynaptic membrane organization (GO:0097090)2.44243182
79regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.44113503
80lung-associated mesenchyme development (GO:0060484)2.43960442
81positive regulation of p38MAPK cascade (GO:1900745)2.42964346
82negative regulation of fibrinolysis (GO:0051918)2.42849599
83low-density lipoprotein particle clearance (GO:0034383)2.42766854
84regulation of complement activation (GO:0030449)2.41952284
85triglyceride homeostasis (GO:0070328)2.41598331
86acylglycerol homeostasis (GO:0055090)2.41598331
87serine family amino acid catabolic process (GO:0009071)2.40745120
88G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.40013309
89cell migration involved in sprouting angiogenesis (GO:0002042)2.39054681
90lipoprotein metabolic process (GO:0042157)2.38518094
91regulation of protein polyubiquitination (GO:1902914)2.38066537
92positive regulation of catenin import into nucleus (GO:0035413)2.37765744
93negative regulation of DNA repair (GO:0045738)2.37545292
94biotin metabolic process (GO:0006768)2.36911211
95positive regulation of glycogen biosynthetic process (GO:0045725)2.35257639
96regulation of fibrinolysis (GO:0051917)2.34844324
97regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.34610382
98tyrosine metabolic process (GO:0006570)2.33911894
99aromatic amino acid family catabolic process (GO:0009074)2.32920593
100sister chromatid segregation (GO:0000819)2.31703650
101regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.31409045
102metaphase plate congression (GO:0051310)2.31068333
103* positive regulation of mesenchymal cell proliferation (GO:0002053)2.30954697
104neuron projection extension involved in neuron projection guidance (GO:1902284)2.30584746
105axon extension involved in axon guidance (GO:0048846)2.30584746
106chromatin remodeling at centromere (GO:0031055)2.30495929
107nitrogen cycle metabolic process (GO:0071941)2.30286449
108hemidesmosome assembly (GO:0031581)2.30151494
109prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.30128785
110regulation of integrin activation (GO:0033623)2.29876427
111heterochromatin organization (GO:0070828)2.29792738
112otic vesicle formation (GO:0030916)2.29570036
113artery development (GO:0060840)2.28538129
114cysteine metabolic process (GO:0006534)2.28303140
115fatty acid oxidation (GO:0019395)2.27533323
116embryonic camera-type eye development (GO:0031076)2.27338661
117glomerular filtration (GO:0003094)2.27125243
118regulation of fatty acid oxidation (GO:0046320)2.26013454
119protein localization to endosome (GO:0036010)2.25499259
120renal filtration (GO:0097205)2.25224817
121epithelial cell differentiation involved in prostate gland development (GO:0060742)2.24532819
122endodermal cell differentiation (GO:0035987)2.24184750
123regulation of centrosome duplication (GO:0010824)2.23723200
124chondrocyte proliferation (GO:0035988)2.23547578
125very-low-density lipoprotein particle assembly (GO:0034379)2.23121559
126endothelial cell morphogenesis (GO:0001886)2.22901272
127chondrocyte development (GO:0002063)2.22899146
128negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.22452784
129intracellular lipid transport (GO:0032365)2.22237692
130amino-acid betaine metabolic process (GO:0006577)2.21094971
131lipid oxidation (GO:0034440)2.20846641
132anterior/posterior axis specification, embryo (GO:0008595)2.19786673
133double-strand break repair via nonhomologous end joining (GO:0006303)2.18328722
134non-recombinational repair (GO:0000726)2.18328722
135regulation of centrosome cycle (GO:0046605)2.17697495
136* gastrulation with mouth forming second (GO:0001702)2.17049742
137CENP-A containing nucleosome assembly (GO:0034080)2.16973030
138regulation of transforming growth factor beta2 production (GO:0032909)2.16053866
139* regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.15738523
140positive regulation of SMAD protein import into nucleus (GO:0060391)2.15316049
141mitotic metaphase plate congression (GO:0007080)2.15086223
142regulation of hippo signaling (GO:0035330)2.13593239
143regulation of cell fate specification (GO:0042659)2.13219742
144NLS-bearing protein import into nucleus (GO:0006607)2.13212025
145generation of neurons (GO:0048699)2.12764154
146negative regulation of keratinocyte proliferation (GO:0010839)2.12642207
147kinetochore organization (GO:0051383)2.12408654
148lymphangiogenesis (GO:0001946)2.12210538
149* regulation of non-canonical Wnt signaling pathway (GO:2000050)2.10750408
150* morphogenesis of an epithelial sheet (GO:0002011)2.10336531
151L-serine metabolic process (GO:0006563)2.09823293
152mitotic sister chromatid segregation (GO:0000070)2.09515329
153organ growth (GO:0035265)2.07943379
154establishment of nucleus localization (GO:0040023)2.07453490
155apical protein localization (GO:0045176)2.06793601
156anterior/posterior axis specification (GO:0009948)2.06396324
157establishment of integrated proviral latency (GO:0075713)2.05734609
158protein localization to chromosome, centromeric region (GO:0071459)2.05049917
159positive regulation of dendritic spine morphogenesis (GO:0061003)2.04874217
160glutamine metabolic process (GO:0006541)2.03103715
161histone exchange (GO:0043486)2.01057104
162mitotic chromosome condensation (GO:0007076)1.99917513
163regulation of cardioblast differentiation (GO:0051890)1.99712097
164regulation of DNA endoreduplication (GO:0032875)1.96646862
165establishment of monopolar cell polarity (GO:0061162)1.94663459
166establishment or maintenance of monopolar cell polarity (GO:0061339)1.94663459
167glomerular visceral epithelial cell development (GO:0072015)1.93921570
168DNA unwinding involved in DNA replication (GO:0006268)1.92348693
169ventricular cardiac muscle cell development (GO:0055015)1.91341223
170embryonic axis specification (GO:0000578)1.90974328
171DNA replication-dependent nucleosome organization (GO:0034723)1.89352965
172DNA replication-dependent nucleosome assembly (GO:0006335)1.89352965
173sister chromatid cohesion (GO:0007062)1.88104695
174replication fork processing (GO:0031297)1.88011355
175negative regulation of astrocyte differentiation (GO:0048712)1.87529623
176spindle checkpoint (GO:0031577)1.87455163
177outer ear morphogenesis (GO:0042473)1.86908883
178regulation of sister chromatid cohesion (GO:0007063)1.86597536
179regulation of chromosome segregation (GO:0051983)1.86115558
180appendage development (GO:0048736)1.85703053
181limb development (GO:0060173)1.85703053
182asymmetric protein localization (GO:0008105)1.85617961
183gap junction assembly (GO:0016264)1.85257056
184branching involved in salivary gland morphogenesis (GO:0060445)1.84077947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.00834670
2E2F7_22180533_ChIP-Seq_HELA_Human3.64931761
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.56243371
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.28412558
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.95956923
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.88722724
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.85764471
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79100740
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.74195148
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72322509
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.66881724
12GBX2_23144817_ChIP-Seq_PC3_Human2.60622544
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.58422191
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.57735249
15CLOCK_20551151_ChIP-Seq_293T_Human2.57130403
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.43990652
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29599460
18FUS_26573619_Chip-Seq_HEK293_Human2.23398248
19AR_21909140_ChIP-Seq_LNCAP_Human2.11626455
20ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.04917946
21* SALL1_21062744_ChIP-ChIP_HESCs_Human2.04787816
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04694053
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.02452178
24POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01733741
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.92390964
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88608288
27POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85128228
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.84896369
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.83002403
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.82541668
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80822073
32EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79905425
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78794439
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77502739
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75491506
36EWS_26573619_Chip-Seq_HEK293_Human1.74826193
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.73472152
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.73321109
39TAF15_26573619_Chip-Seq_HEK293_Human1.69110034
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.68494162
41P300_19829295_ChIP-Seq_ESCs_Human1.68026302
42* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.66040791
43* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65097631
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.62318134
45* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62270168
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.61690582
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57305703
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55285861
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53833583
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.53543079
51CJUN_26792858_Chip-Seq_BT549_Human1.51709497
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50167674
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48736519
54PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47710038
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.47142104
56* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.47102272
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46769723
58* CDX2_20551321_ChIP-Seq_CACO-2_Human1.44731681
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44591787
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41997864
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40988809
62TP53_16413492_ChIP-PET_HCT116_Human1.38892368
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38641818
64BRD4_25478319_ChIP-Seq_HGPS_Human1.38215488
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.37777278
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37325835
67FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.36553708
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.36452232
69KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35865554
70EZH2_22144423_ChIP-Seq_EOC_Human1.34243660
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34135012
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34125892
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33283108
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.30138864
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.30031548
76P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29358783
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29243979
78SOX9_26525672_Chip-Seq_HEART_Mouse1.28913476
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.28014901
80IGF1R_20145208_ChIP-Seq_DFB_Human1.27917906
81SOX2_16153702_ChIP-ChIP_HESCs_Human1.27783334
82FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27622533
83STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.27555349
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.25956245
85FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.25619502
86SOX2_27498859_Chip-Seq_STOMACH_Mouse1.25602576
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25521225
88* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25218595
89SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23925963
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22883604
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22883604
92* STAT3_23295773_ChIP-Seq_U87_Human1.22867138
93CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21658794
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20932028
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19983118
96TCF4_18268006_ChIP-ChIP_LS174T_Human1.19777479
97TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18806721
98ZNF274_21170338_ChIP-Seq_K562_Hela1.18311460
99AHR_22903824_ChIP-Seq_MCF-7_Human1.17976834
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15857396
101TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.15231505
102PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12977817
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.12628804
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.12054350
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11894390
106TBX20_22080862_ChIP-Seq_HEART_Mouse1.11403641
107TBX20_22328084_ChIP-Seq_HEART_Mouse1.11403641
108RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11304384
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11132611
110TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10475632
111PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10299583
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.10236977
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09931193
114CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08661593
115E2F1_21310950_ChIP-Seq_MCF-7_Human1.06613123
116TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06544637
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06426063
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.06279369
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06017951
120CBX2_27304074_Chip-Seq_ESCs_Mouse1.05937719
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05350969
122MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04995686
123GATA2_21666600_ChIP-Seq_HMVEC_Human1.04826962
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04431138
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04334432
126HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04298312
127* TCF4_23295773_ChIP-Seq_U87_Human1.03340378
128ELK1_19687146_ChIP-ChIP_HELA_Human1.03334342
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.03197265
130* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02652106
131TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02453524
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02453524
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.02106271
134ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01806122
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01351216
136KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01347466
137TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01084196
138FLI1_27457419_Chip-Seq_LIVER_Mouse1.00705385
139ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00554594
140RNF2_27304074_Chip-Seq_NSC_Mouse1.00163014
141FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00023253
142SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.99993270
143SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.99993270
144TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99459337
145* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99170297
146SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99133035
147FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98671602
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98405091
149TP53_18474530_ChIP-ChIP_U2OS_Human0.98178165
150GATA6_25053715_ChIP-Seq_YYC3_Human0.97950746
151UBF1/2_26484160_Chip-Seq_HMECs_Human0.97871527
152AR_21572438_ChIP-Seq_LNCaP_Human0.97533460
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.97522395
154NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97418575
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97030600
156SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96821559
157VDR_22108803_ChIP-Seq_LS180_Human0.96243954
158LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95552273
159ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94928948
160HNF4A_19822575_ChIP-Seq_HepG2_Human0.94546185
161AR_25329375_ChIP-Seq_VCAP_Human0.94071401
162CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93995456
163SOX2_20726797_ChIP-Seq_SW620_Human0.93837031
164* RUNX1_27514584_Chip-Seq_MCF-7_Human0.93780631
165GATA4_25053715_ChIP-Seq_YYC3_Human0.93734857
166PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93578671
167EZH2_27294783_Chip-Seq_NPCs_Mouse0.92644161
168PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92258629
169SOX2_21211035_ChIP-Seq_LN229_Gbm0.92190401
170SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92162452
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.91589457
172TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90362875
173* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.90193992

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.68140798
2MP0003705_abnormal_hypodermis_morpholog3.75482323
3MP0005275_abnormal_skin_tensile3.09851724
4MP0002139_abnormal_hepatobiliary_system3.01242576
5MP0005360_urolithiasis2.69103879
6MP0005365_abnormal_bile_salt2.56958681
7MP0005503_abnormal_tendon_morphology2.54987743
8MP0003252_abnormal_bile_duct2.48607800
9MP0005085_abnormal_gallbladder_physiolo2.33092901
10MP0004272_abnormal_basement_membrane2.20744302
11MP0009384_cardiac_valve_regurgitation1.92907756
12MP0010030_abnormal_orbit_morphology1.89260433
13MP0008057_abnormal_DNA_replication1.87317745
14MP0005171_absent_coat_pigmentation1.85106610
15MP0009053_abnormal_anal_canal1.77381905
16MP0004185_abnormal_adipocyte_glucose1.72022092
17MP0005076_abnormal_cell_differentiation1.69709437
18MP0002938_white_spotting1.69547903
19MP0005666_abnormal_adipose_tissue1.69282390
20* MP0001293_anophthalmia1.67117079
21MP0010234_abnormal_vibrissa_follicle1.63062341
22MP0005670_abnormal_white_adipose1.61171833
23MP0006292_abnormal_olfactory_placode1.59282721
24MP0000569_abnormal_digit_pigmentation1.58286539
25MP0003119_abnormal_digestive_system1.57085538
26MP0005187_abnormal_penis_morphology1.55306615
27* MP0002233_abnormal_nose_morphology1.54505168
28MP0003136_yellow_coat_color1.53919008
29MP0002282_abnormal_trachea_morphology1.53387513
30* MP0002060_abnormal_skin_morphology1.53066981
31MP0010352_gastrointestinal_tract_polyps1.51567151
32MP0010329_abnormal_lipoprotein_level1.51021385
33MP0003566_abnormal_cell_adhesion1.49081591
34MP0002009_preneoplasia1.47210026
35MP0010094_abnormal_chromosome_stability1.45950816
36MP0002249_abnormal_larynx_morphology1.45934010
37MP0001958_emphysema1.45522334
38MP0003300_gastrointestinal_ulcer1.44289227
39MP0003279_aneurysm1.42518891
40* MP0002084_abnormal_developmental_patter1.42302990
41MP0010368_abnormal_lymphatic_system1.41884284
42* MP0001286_abnormal_eye_development1.40456276
43MP0005508_abnormal_skeleton_morphology1.33975255
44MP0000778_abnormal_nervous_system1.33710356
45MP0002108_abnormal_muscle_morphology1.33525356
46MP0000049_abnormal_middle_ear1.32369703
47MP0003385_abnormal_body_wall1.32322317
48MP0008932_abnormal_embryonic_tissue1.30709207
49MP0000579_abnormal_nail_morphology1.29679753
50MP0003045_fibrosis1.29625654
51MP0004957_abnormal_blastocyst_morpholog1.29370635
52MP0005623_abnormal_meninges_morphology1.26974142
53MP0009697_abnormal_copulation1.25465945
54MP0005248_abnormal_Harderian_gland1.25456650
55MP0004130_abnormal_muscle_cell1.24091884
56MP0002896_abnormal_bone_mineralization1.22964838
57MP0008875_abnormal_xenobiotic_pharmacok1.22658946
58MP0003283_abnormal_digestive_organ1.22052726
59* MP0002085_abnormal_embryonic_tissue1.21220380
60MP0000733_abnormal_muscle_development1.21148133
61MP0005375_adipose_tissue_phenotype1.20288950
62MP0002168_other_aberrant_phenotype1.19915519
63MP0003111_abnormal_nucleus_morphology1.19209918
64MP0005023_abnormal_wound_healing1.18022756
65MP0009278_abnormal_bone_marrow1.17115349
66MP0003122_maternal_imprinting1.16429994
67* MP0003861_abnormal_nervous_system1.14226113
68MP0010678_abnormal_skin_adnexa1.13688153
69* MP0003935_abnormal_craniofacial_develop1.12335493
70MP0009250_abnormal_appendicular_skeleto1.11820098
71MP0001672_abnormal_embryogenesis/_devel1.10722862
72MP0005380_embryogenesis_phenotype1.10722862
73MP0005257_abnormal_intraocular_pressure1.10628446
74MP0005367_renal/urinary_system_phenotyp1.10253644
75MP0000516_abnormal_urinary_system1.10253644
76MP0003077_abnormal_cell_cycle1.10042526
77MP0003693_abnormal_embryo_hatching1.07684082
78MP0009672_abnormal_birth_weight1.06760616
79* MP0009703_decreased_birth_body1.06442925
80MP0003121_genomic_imprinting1.05689323
81MP0000371_diluted_coat_color1.04892638
82MP0004019_abnormal_vitamin_homeostasis1.02919275
83MP0005408_hypopigmentation1.02893422
84MP0000383_abnormal_hair_follicle1.02759113
85MP0002234_abnormal_pharynx_morphology1.02742129
86MP0002166_altered_tumor_susceptibility1.02688413
87MP0003984_embryonic_growth_retardation1.02672156
88MP0001666_abnormal_nutrient_absorption1.02393795
89MP0000537_abnormal_urethra_morphology1.02121915
90MP0003941_abnormal_skin_development1.01947112
91MP0004270_analgesia1.01454593
92MP0002088_abnormal_embryonic_growth/wei1.01359851
93MP0001177_atelectasis1.01222583
94MP0003091_abnormal_cell_migration1.01139364
95MP0008058_abnormal_DNA_repair1.01112075
96MP0000428_abnormal_craniofacial_morphol1.00960724
97MP0003453_abnormal_keratinocyte_physiol1.00899867
98MP0000631_abnormal_neuroendocrine_gland1.00488061
99MP0003115_abnormal_respiratory_system0.99653664
100MP0004133_heterotaxia0.99437564
101MP0000163_abnormal_cartilage_morphology0.98537764
102MP0000647_abnormal_sebaceous_gland0.98345992
103MP0000767_abnormal_smooth_muscle0.97650390
104MP0002115_abnormal_skeleton_extremities0.97422739
105* MP0002116_abnormal_craniofacial_bone0.96862248
106* MP0000432_abnormal_head_morphology0.96439448
107MP0003718_maternal_effect0.96353422
108MP0001730_embryonic_growth_arrest0.93866833
109* MP0002932_abnormal_joint_morphology0.93728325
110MP0002102_abnormal_ear_morphology0.93581805
111MP0001299_abnormal_eye_distance/0.93037306
112MP0001697_abnormal_embryo_size0.93001772
113MP0000566_synostosis0.92811674
114MP0003942_abnormal_urinary_system0.92801087
115MP0004197_abnormal_fetal_growth/weight/0.92186338
116MP0000609_abnormal_liver_physiology0.90344720
117MP0001849_ear_inflammation0.90036605
118* MP0003937_abnormal_limbs/digits/tail_de0.89026912
119MP0000003_abnormal_adipose_tissue0.88933206
120MP0001915_intracranial_hemorrhage0.88327445
121MP0002751_abnormal_autonomic_nervous0.88034905
122MP0000462_abnormal_digestive_system0.86491993
123MP0005220_abnormal_exocrine_pancreas0.85746940
124MP0002971_abnormal_brown_adipose0.84797463
125MP0001661_extended_life_span0.84393046
126* MP0005391_vision/eye_phenotype0.83867740
127MP0005332_abnormal_amino_acid0.83781633
128* MP0002697_abnormal_eye_size0.83356375
129MP0003890_abnormal_embryonic-extraembry0.82258634
130MP0004264_abnormal_extraembryonic_tissu0.81664356
131MP0003191_abnormal_cellular_cholesterol0.81656277
132MP0010630_abnormal_cardiac_muscle0.81414221
133MP0000534_abnormal_ureter_morphology0.81318574
134* MP0002081_perinatal_lethality0.81303533
135* MP0002092_abnormal_eye_morphology0.81231707
136MP0006054_spinal_hemorrhage0.80432993
137MP0003567_abnormal_fetal_cardiomyocyte0.79659914
138* MP0003755_abnormal_palate_morphology0.79287895
139* MP0002109_abnormal_limb_morphology0.78764855
140MP0002254_reproductive_system_inflammat0.78697417
141MP0009115_abnormal_fat_cell0.78146892
142MP0002295_abnormal_pulmonary_circulatio0.77959185
143MP0002086_abnormal_extraembryonic_tissu0.76914020
144* MP0002118_abnormal_lipid_homeostasis0.76872711
145* MP0002111_abnormal_tail_morphology0.76607232
146MP0001346_abnormal_lacrimal_gland0.76442584
147* MP0000762_abnormal_tongue_morphology0.76112680
148* MP0002114_abnormal_axial_skeleton0.76013766
149MP0003943_abnormal_hepatobiliary_system0.75665136
150MP0003938_abnormal_ear_development0.74934353
151MP0005197_abnormal_uvea_morphology0.73881540
152MP0009780_abnormal_chondrocyte_physiolo0.72990349
153MP0006072_abnormal_retinal_apoptosis0.72048389
154MP0001879_abnormal_lymphatic_vessel0.71432299
155MP0008877_abnormal_DNA_methylation0.70805830

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.06522565
2Shallow orbits (HP:0000586)3.69754555
3Cerebral aneurysm (HP:0004944)3.66949349
4Broad metatarsal (HP:0001783)3.58827430
5Premature rupture of membranes (HP:0001788)3.37148877
6Turricephaly (HP:0000262)3.33688945
7Ankle contracture (HP:0006466)3.21251139
8Aortic dissection (HP:0002647)3.12677005
9Aortic aneurysm (HP:0004942)3.11987232
10Coronal craniosynostosis (HP:0004440)3.05889988
11Deep venous thrombosis (HP:0002625)3.00867806
12Mitral valve prolapse (HP:0001634)2.81465167
13Hepatoblastoma (HP:0002884)2.80726836
14Ulnar bowing (HP:0003031)2.77426380
15Short 4th metacarpal (HP:0010044)2.63797508
16Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63797508
17Hypoplastic ischia (HP:0003175)2.58223789
18Atrophic scars (HP:0001075)2.55033450
19Cutaneous finger syndactyly (HP:0010554)2.53715190
20Aneurysm (HP:0002617)2.53086029
21Volvulus (HP:0002580)2.51859028
22Abnormality of the 4th metacarpal (HP:0010012)2.48933143
23Myocardial infarction (HP:0001658)2.46200702
24Abnormality of the ischium (HP:0003174)2.41919751
25Intrahepatic cholestasis (HP:0001406)2.40894384
26Alopecia of scalp (HP:0002293)2.37178828
27Xanthomatosis (HP:0000991)2.32470371
28Cutaneous syndactyly (HP:0012725)2.31873343
29Blue sclerae (HP:0000592)2.30726116
30Lymphangioma (HP:0100764)2.30449149
31Colon cancer (HP:0003003)2.30393857
32Complement deficiency (HP:0004431)2.28220069
33Increased connective tissue (HP:0009025)2.25720774
34Bifid tongue (HP:0010297)2.22871126
35Astrocytoma (HP:0009592)2.20461717
36Abnormality of the astrocytes (HP:0100707)2.20461717
37Follicular hyperkeratosis (HP:0007502)2.17386234
38Abnormality of glutamine family amino acid metabolism (HP:0010902)2.15509505
39Abnormality of the labia minora (HP:0012880)2.14901341
40Cervical subluxation (HP:0003308)2.14717842
41Hypoalphalipoproteinemia (HP:0003233)2.11957680
42Rectal prolapse (HP:0002035)2.10606912
43Type 1 muscle fiber predominance (HP:0003803)2.08904234
44Wide anterior fontanel (HP:0000260)2.08730875
45Preaxial foot polydactyly (HP:0001841)2.07876119
46Spinal cord lesions (HP:0100561)2.06369998
47Syringomyelia (HP:0003396)2.06369998
48Papillary thyroid carcinoma (HP:0002895)2.05540729
49Narrow palate (HP:0000189)2.04774684
50Soft skin (HP:0000977)2.04523766
51Aplasia/Hypoplasia of the sternum (HP:0006714)2.04244550
52Subacute progressive viral hepatitis (HP:0006572)2.03590182
53Bell-shaped thorax (HP:0001591)2.02822572
54Peritonitis (HP:0002586)2.00980354
55Knee flexion contracture (HP:0006380)2.00396896
56Epidermoid cyst (HP:0200040)1.99430313
57Increased nuchal translucency (HP:0010880)1.98918438
58Bladder diverticulum (HP:0000015)1.98729492
59Septo-optic dysplasia (HP:0100842)1.98208514
60Hematochezia (HP:0002573)1.95590522
61Glioma (HP:0009733)1.94823516
62Hypoplasia of the iris (HP:0007676)1.94587499
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.94379788
64Dilatation of the ascending aorta (HP:0005111)1.93394518
65Intestinal atresia (HP:0011100)1.92893804
66Prolonged partial thromboplastin time (HP:0003645)1.92759385
67Cortical dysplasia (HP:0002539)1.92578066
68Abnormality of the common coagulation pathway (HP:0010990)1.92396455
69Ependymoma (HP:0002888)1.92096175
70Neonatal short-limb short stature (HP:0008921)1.91333972
71Abnormality of the nasal septum (HP:0000419)1.90706625
72Osteolytic defects of the phalanges of the hand (HP:0009771)1.90508290
73Osteolytic defects of the hand bones (HP:0009699)1.90508290
74Fragile skin (HP:0001030)1.90491759
75Esophageal varix (HP:0002040)1.90366137
76Abnormality of monocarboxylic acid metabolism (HP:0010996)1.88214921
77Hypochromic microcytic anemia (HP:0004840)1.85688765
78Macroorchidism (HP:0000053)1.85526029
79Aqueductal stenosis (HP:0002410)1.84801850
80Bowed forearm bones (HP:0003956)1.84738906
81Bowing of the arm (HP:0006488)1.84738906
82Abnormal lung lobation (HP:0002101)1.84550051
83Right ventricular cardiomyopathy (HP:0011663)1.83823136
84Disproportionate tall stature (HP:0001519)1.83676841
85Aplasia involving bones of the upper limbs (HP:0009823)1.83168909
86Aplasia of the phalanges of the hand (HP:0009802)1.83168909
87Aplasia involving bones of the extremities (HP:0009825)1.83168909
88Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83083826
89Anophthalmia (HP:0000528)1.82946194
90Elbow flexion contracture (HP:0002987)1.82285152
91Chromsome breakage (HP:0040012)1.82101992
92Thin bony cortex (HP:0002753)1.81694168
93Midline defect of the nose (HP:0004122)1.81610533
94Deviation of the hallux (HP:0010051)1.79076854
95Tibial bowing (HP:0002982)1.78366402
96Renal hypoplasia (HP:0000089)1.78216571
97Hyperextensible skin (HP:0000974)1.78050126
98Ectopia lentis (HP:0001083)1.78024979
99Exostoses (HP:0100777)1.75746085
100Abnormality of proline metabolism (HP:0010907)1.75651513
101Hydroxyprolinuria (HP:0003080)1.75651513
102Hypolipoproteinemia (HP:0010981)1.74251800
103Absent eyebrow (HP:0002223)1.74245961
104Hypoplastic labia majora (HP:0000059)1.74019145
105Abnormality of the intrinsic pathway (HP:0010989)1.73047251
106Embryonal renal neoplasm (HP:0011794)1.72270737
107Genu recurvatum (HP:0002816)1.71950017
108Mesomelia (HP:0003027)1.71615934
109Bilateral microphthalmos (HP:0007633)1.71381330
110High anterior hairline (HP:0009890)1.71171771
111Hip contracture (HP:0003273)1.70780365
112Vertebral arch anomaly (HP:0008438)1.68471941
113Hallux valgus (HP:0001822)1.67585308
114Hepatocellular carcinoma (HP:0001402)1.67144570
115Cardiovascular calcification (HP:0011915)1.66931084
116Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66882935
117Spondylolisthesis (HP:0003302)1.66535256
118Nephritis (HP:0000123)1.66234664
119Absent radius (HP:0003974)1.65573351
120Rhabdomyosarcoma (HP:0002859)1.65453210
121Omphalocele (HP:0001539)1.65389240
122Striae distensae (HP:0001065)1.65195862
123Focal segmental glomerulosclerosis (HP:0000097)1.64604564
124Ectopic kidney (HP:0000086)1.62688656
125Broad thumb (HP:0011304)1.62645233
126Nephroblastoma (Wilms tumor) (HP:0002667)1.62490718
127Duplication of thumb phalanx (HP:0009942)1.61941623
128Spinal rigidity (HP:0003306)1.61869525
129Camptodactyly of toe (HP:0001836)1.61614031
130Facial cleft (HP:0002006)1.61187263
131Meckel diverticulum (HP:0002245)1.60793434
132Medulloblastoma (HP:0002885)1.60544468
133Choanal stenosis (HP:0000452)1.60484524
134Abnormality of complement system (HP:0005339)1.60222599
135Neoplasm of the oral cavity (HP:0100649)1.59746610
136Overgrowth (HP:0001548)1.59303645
137Mildly elevated creatine phosphokinase (HP:0008180)1.58917891
138Esophageal atresia (HP:0002032)1.58908953
139Arterial tortuosity (HP:0005116)1.58906757
140Gastrointestinal atresia (HP:0002589)1.58892440
141Mitral stenosis (HP:0001718)1.58577912
142Vascular tortuosity (HP:0004948)1.58525070
143Vitreoretinal degeneration (HP:0000655)1.58393493
144Labial hypoplasia (HP:0000066)1.58249876
145Hypoglycemic coma (HP:0001325)1.58222464
146Coarse hair (HP:0002208)1.57790059
147Abnormality of the labia majora (HP:0012881)1.57508009
148Abnormality of the ileum (HP:0001549)1.57194308
149Myelomeningocele (HP:0002475)1.57142292
150Spastic diplegia (HP:0001264)1.56760254
151Skin nodule (HP:0200036)1.56613485
152Hypoplastic female external genitalia (HP:0012815)1.55642944
153Missing ribs (HP:0000921)1.54965212
154Absent forearm bone (HP:0003953)1.53013035
155Aplasia involving forearm bones (HP:0009822)1.53013035
156Skull defect (HP:0001362)1.52886584
157Short hallux (HP:0010109)1.51483139
158Abnormality of chromosome stability (HP:0003220)1.51244478
159Decreased lacrimation (HP:0000633)1.51030788
160Bifid scrotum (HP:0000048)1.50787110
161Fibular hypoplasia (HP:0003038)1.49788002
162Limited hip movement (HP:0008800)1.48985995
163Alacrima (HP:0000522)1.48149274
164Anal stenosis (HP:0002025)1.45687017
165Neoplasm of the adrenal cortex (HP:0100641)1.45118553
166Abnormality of the antihelix (HP:0009738)1.44152009
167Pancreatic islet-cell hyperplasia (HP:0004510)1.44005502
1682-3 toe syndactyly (HP:0004691)1.43946526
169Neoplasm of the small intestine (HP:0100833)1.43263783
170Aplasia/Hypoplasia of the tibia (HP:0005772)1.43069534
171Renovascular hypertension (HP:0100817)1.42525664
172Morphological abnormality of the middle ear (HP:0008609)1.42062339
173Neoplasm of striated muscle (HP:0009728)1.42001995
174Aplasia/Hypoplasia of the uvula (HP:0010293)1.41735701
175Bronchomalacia (HP:0002780)1.41434094
176Long clavicles (HP:0000890)1.40502715
177Aplasia/Hypoplasia of the hallux (HP:0008362)1.38725239
178Abnormality of the middle phalanges of the toes (HP:0010183)1.38713006
179Bicornuate uterus (HP:0000813)1.38632494
180Malignant gastrointestinal tract tumors (HP:0006749)1.35500563
181Gastrointestinal carcinoma (HP:0002672)1.35500563
182Drooling (HP:0002307)1.34666155
183Partial duplication of thumb phalanx (HP:0009944)1.34517806
184Genital tract atresia (HP:0001827)1.34492358
185Vaginal atresia (HP:0000148)1.34462213
186Cupped ear (HP:0000378)1.34020471

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.49859759
2DDR23.89606078
3SIK13.50629746
4PDGFRA2.88013139
5PNCK2.77527495
6MKNK22.65043894
7CAMK1D2.62753479
8TRIB32.41276823
9CDK122.25702361
10FRK2.25003601
11MKNK12.24276375
12CDC72.19277844
13FGFR22.19264695
14CASK2.16404708
15TNIK2.07042304
16TTK2.06634081
17TTN2.05428494
18RIPK12.01867630
19CAMK1G2.01255864
20MST1R1.97728788
21ICK1.97405837
22PBK1.89623509
23WNK31.87596298
24TSSK61.87272865
25PKN21.78108796
26BMX1.77556391
27BMPR1B1.72651641
28TGFBR21.71600151
29STK31.71191972
30EPHA31.63649589
31PTK61.62499566
32WEE11.58377372
33MET1.55837503
34CDK61.52977326
35BRSK21.48665587
36MAPK151.48422799
37ACVR1B1.46820560
38PDGFRB1.44204062
39PLK31.41910959
40FGFR41.39993675
41SRPK11.37307051
42MAP3K101.34637271
43MTOR1.32661025
44PLK41.32362293
45TRPM71.32319672
46EPHB21.30930133
47LATS21.28998536
48BCR1.26349323
49FGFR31.26133153
50MAP3K41.26004921
51MARK11.24984174
52TAF11.24308307
53NUAK11.23997798
54DMPK1.21605249
55STK38L1.15633937
56BUB11.15315634
57STK391.15313731
58ERN11.14582146
59FGFR11.14375231
60PIK3CA1.13808516
61ZAK1.11466042
62PRKAA21.09693043
63NEK11.08468127
64MAP3K61.07276979
65PAK21.06276885
66PLK11.02012569
67NLK0.99041099
68ERBB40.97815314
69ERBB30.97408721
70JAK10.97263573
71INSRR0.96648419
72EPHB10.96457939
73BRD40.96370294
74DYRK1B0.94958448
75NEK20.94933457
76PRKD20.94564251
77FER0.93222016
78EIF2AK30.93182478
79PTK20.91381593
80EEF2K0.90067004
81EPHA40.89755520
82NTRK10.88207807
83OBSCN0.85725100
84NEK90.85526400
85ATM0.85013308
86CDK90.82951383
87CSK0.82668811
88TYRO30.79908340
89FLT30.79854882
90CHEK20.79665460
91* GSK3A0.74061215
92MAPK110.72662140
93CSNK1A1L0.72048957
94PLK20.72008965
95TRIM280.70206735
96ATR0.69807326
97CSNK1G20.69522317
98ERBB20.69200604
99CDK30.69047289
100PRKAA10.68948914
101CHEK10.68452167
102SGK30.67642422
103BCKDK0.66941268
104AURKB0.64856357
105MAP3K70.64228327
106OXSR10.62703770
107LMTK20.62134070
108CHUK0.62008136
109TAOK30.61418039
110FGR0.60019474
111DYRK20.58531540
112AKT30.58433731
113WNK40.57032363
114* CSNK1E0.56521477
115PRKDC0.55894519
116NTRK20.55589357
117CDK10.55499375
118PRKD10.55452243
119EPHA20.55023050
120SGK4940.53878498
121SGK2230.53878498
122* CSNK1G10.53205923
123CSNK1G30.50398343
124VRK10.50287396
125STK380.49544314
126STK240.49300518
127MATK0.49200514
128INSR0.48910351
129PRKCE0.47594076
130JAK20.47103087
131BRSK10.46876170
132TIE10.46682846
133LRRK20.46587405
134CDK20.46316058
135PAK40.45292528
136MAP2K70.44308916
137CDK70.43554382
138CSNK1D0.43409154
139STK100.43133816
140WNK10.43133701
141EGFR0.41878620
142YES10.41155170
143MAP3K90.41114658
144MELK0.40895100
145CDC42BPA0.40193200
146ABL10.39606531
147ROCK10.39517175
148MAPK10.39102410
149RET0.38920886
150* GSK3B0.38264456
151IGF1R0.37299845
152CSF1R0.34815882
153PINK10.34796795
154SGK20.34521004
155CDK40.34100795
156PAK30.33509668
157RPS6KC10.33495060
158RPS6KL10.33495060
159PIM10.33466676
160PRKCH0.32299179
161TGFBR10.32296899
162TYK20.30387877

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.41641987
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.42505150
3Non-homologous end-joining_Homo sapiens_hsa034502.33334935
4Lysine degradation_Homo sapiens_hsa003102.32399152
5Fatty acid biosynthesis_Homo sapiens_hsa000612.26679612
6Fatty acid degradation_Homo sapiens_hsa000712.26575901
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24062895
8Fatty acid metabolism_Homo sapiens_hsa012122.20288455
9PPAR signaling pathway_Homo sapiens_hsa033202.07321135
10Arginine biosynthesis_Homo sapiens_hsa002202.01474021
11Complement and coagulation cascades_Homo sapiens_hsa046102.00173010
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93254509
13ECM-receptor interaction_Homo sapiens_hsa045121.90252021
14Tryptophan metabolism_Homo sapiens_hsa003801.84994294
15Propanoate metabolism_Homo sapiens_hsa006401.74591776
16Adherens junction_Homo sapiens_hsa045201.67456783
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65691890
18Pentose and glucuronate interconversions_Homo sapiens_hsa000401.62310076
19Cell cycle_Homo sapiens_hsa041101.59513554
20Mismatch repair_Homo sapiens_hsa034301.56895957
21Caffeine metabolism_Homo sapiens_hsa002321.56891948
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51137267
23Focal adhesion_Homo sapiens_hsa045101.46382350
24Vitamin B6 metabolism_Homo sapiens_hsa007501.43688292
25Fanconi anemia pathway_Homo sapiens_hsa034601.41761736
26RNA transport_Homo sapiens_hsa030131.41186021
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38819499
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36494002
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35837445
30Basal cell carcinoma_Homo sapiens_hsa052171.32758226
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32202142
32Protein digestion and absorption_Homo sapiens_hsa049741.30976422
33Basal transcription factors_Homo sapiens_hsa030221.27848809
34mRNA surveillance pathway_Homo sapiens_hsa030151.25016666
35Staphylococcus aureus infection_Homo sapiens_hsa051501.24984956
36One carbon pool by folate_Homo sapiens_hsa006701.24631092
37Cysteine and methionine metabolism_Homo sapiens_hsa002701.23655700
38Bile secretion_Homo sapiens_hsa049761.23066675
39Butanoate metabolism_Homo sapiens_hsa006501.22963180
40beta-Alanine metabolism_Homo sapiens_hsa004101.21522671
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17814507
42Small cell lung cancer_Homo sapiens_hsa052221.17800716
43Proteoglycans in cancer_Homo sapiens_hsa052051.16411525
44DNA replication_Homo sapiens_hsa030301.15426988
45Starch and sucrose metabolism_Homo sapiens_hsa005001.11793790
46Selenocompound metabolism_Homo sapiens_hsa004501.11086851
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10905923
48Sulfur metabolism_Homo sapiens_hsa009201.10406163
49ABC transporters_Homo sapiens_hsa020101.08980564
50Insulin resistance_Homo sapiens_hsa049311.06558419
51Hippo signaling pathway_Homo sapiens_hsa043901.06089444
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05314368
53Peroxisome_Homo sapiens_hsa041461.03177288
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02370795
55MicroRNAs in cancer_Homo sapiens_hsa052061.02111734
56TGF-beta signaling pathway_Homo sapiens_hsa043501.01938850
57Fat digestion and absorption_Homo sapiens_hsa049750.99847452
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99572247
59Axon guidance_Homo sapiens_hsa043600.99209716
60Histidine metabolism_Homo sapiens_hsa003400.97530577
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.97083807
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96067454
63Hedgehog signaling pathway_Homo sapiens_hsa043400.95311438
64RNA degradation_Homo sapiens_hsa030180.94224555
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94093372
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93796561
67Nucleotide excision repair_Homo sapiens_hsa034200.91276565
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91141275
69Amoebiasis_Homo sapiens_hsa051460.90160931
70AMPK signaling pathway_Homo sapiens_hsa041520.89268588
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88354819
72Retinol metabolism_Homo sapiens_hsa008300.88262552
73Protein export_Homo sapiens_hsa030600.88147436
74mTOR signaling pathway_Homo sapiens_hsa041500.87913905
75Homologous recombination_Homo sapiens_hsa034400.87402816
76Oocyte meiosis_Homo sapiens_hsa041140.86553102
77Spliceosome_Homo sapiens_hsa030400.86414520
78Chemical carcinogenesis_Homo sapiens_hsa052040.86099187
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85689948
80Thyroid cancer_Homo sapiens_hsa052160.85224111
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82067879
82Notch signaling pathway_Homo sapiens_hsa043300.81605097
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78630075
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.77813407
85Tyrosine metabolism_Homo sapiens_hsa003500.76932041
86Chronic myeloid leukemia_Homo sapiens_hsa052200.76872236
87Melanogenesis_Homo sapiens_hsa049160.75795674
88Prostate cancer_Homo sapiens_hsa052150.75636189
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75274273
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75025333
91Bladder cancer_Homo sapiens_hsa052190.74156488
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.74031622
93Glycerolipid metabolism_Homo sapiens_hsa005610.72071307
94Arginine and proline metabolism_Homo sapiens_hsa003300.68644192
95Phenylalanine metabolism_Homo sapiens_hsa003600.66839344
96Vitamin digestion and absorption_Homo sapiens_hsa049770.65902489
97Thyroid hormone synthesis_Homo sapiens_hsa049180.65770949
98Colorectal cancer_Homo sapiens_hsa052100.65534667
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64638320
100Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63099702
101RNA polymerase_Homo sapiens_hsa030200.61236952
102Nicotine addiction_Homo sapiens_hsa050330.61227593
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61001810
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.60741354
105Insulin signaling pathway_Homo sapiens_hsa049100.58049409
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56611554
107p53 signaling pathway_Homo sapiens_hsa041150.56082569
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55339280
109Tight junction_Homo sapiens_hsa045300.55091222
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.53347786
111Taste transduction_Homo sapiens_hsa047420.53146858
112Dorso-ventral axis formation_Homo sapiens_hsa043200.51788199
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51770560
114Melanoma_Homo sapiens_hsa052180.51140857
115Glucagon signaling pathway_Homo sapiens_hsa049220.50855167
116Endometrial cancer_Homo sapiens_hsa052130.50729242
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50666869
118Alcoholism_Homo sapiens_hsa050340.50502042
119Base excision repair_Homo sapiens_hsa034100.49751172
120Renin-angiotensin system_Homo sapiens_hsa046140.49725572
121Pathways in cancer_Homo sapiens_hsa052000.48580391
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48577744
123Pyruvate metabolism_Homo sapiens_hsa006200.48484911
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48206586
125Pancreatic cancer_Homo sapiens_hsa052120.47726285
126Fatty acid elongation_Homo sapiens_hsa000620.47713940
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47549402
128Viral myocarditis_Homo sapiens_hsa054160.47156959
129* Wnt signaling pathway_Homo sapiens_hsa043100.46335327
130Carbon metabolism_Homo sapiens_hsa012000.46096395
131Gap junction_Homo sapiens_hsa045400.45961296
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45288567
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44684306
134Dilated cardiomyopathy_Homo sapiens_hsa054140.43783975
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43404592
136Circadian rhythm_Homo sapiens_hsa047100.42014760
137FoxO signaling pathway_Homo sapiens_hsa040680.41845041
138Biosynthesis of amino acids_Homo sapiens_hsa012300.40251078
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.40050269
140Steroid biosynthesis_Homo sapiens_hsa001000.38214868

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