LRIT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phototransduction (GO:0007602)9.18240998
2phototransduction, visible light (GO:0007603)9.12190106
3GMP metabolic process (GO:0046037)9.07935103
4detection of visible light (GO:0009584)9.05021447
5detection of light stimulus (GO:0009583)9.03061601
6positive regulation of guanylate cyclase activity (GO:0031284)8.37161649
7protein-chromophore linkage (GO:0018298)8.26112060
8visual perception (GO:0007601)8.00170614
9sensory perception of light stimulus (GO:0050953)7.92666113
10regulation of guanylate cyclase activity (GO:0031282)7.52190920
11eye photoreceptor cell differentiation (GO:0001754)6.66209599
12photoreceptor cell differentiation (GO:0046530)6.66209599
13cellular response to light stimulus (GO:0071482)6.63331066
14detection of external stimulus (GO:0009581)6.32256771
15detection of abiotic stimulus (GO:0009582)6.21190685
16retina development in camera-type eye (GO:0060041)6.17886795
17regulation of cGMP metabolic process (GO:0030823)6.00666888
18positive regulation of cGMP biosynthetic process (GO:0030828)5.66237327
19regulation of cGMP biosynthetic process (GO:0030826)5.29362122
20positive regulation of cGMP metabolic process (GO:0030825)4.99803975
21receptor guanylyl cyclase signaling pathway (GO:0007168)4.73382379
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.71935328
23nonmotile primary cilium assembly (GO:0035058)4.63430448
24detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.49488741
25cellular response to radiation (GO:0071478)4.21483292
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.91981621
27cell morphogenesis involved in neuron differentiation (GO:0048667)3.86224031
28sensory perception (GO:0007600)3.76577253
29regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)3.74425325
30adaptation of signaling pathway (GO:0023058)3.65879107
31regulation of voltage-gated calcium channel activity (GO:1901385)3.58843683
32protein localization to synapse (GO:0035418)3.53677281
33response to light stimulus (GO:0009416)3.45293678
34protein prenylation (GO:0018342)3.44891018
35prenylation (GO:0097354)3.44891018
36peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.37785319
37neuron development (GO:0048666)3.35641177
38cellular potassium ion homeostasis (GO:0030007)3.32193898
39negative regulation of receptor-mediated endocytosis (GO:0048261)3.31947682
40estrogen biosynthetic process (GO:0006703)3.30079284
41regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.28159663
42regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.28159663
43regulation of clathrin-mediated endocytosis (GO:2000369)3.24162958
44retina homeostasis (GO:0001895)3.19646883
45retina layer formation (GO:0010842)3.12501977
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08404579
47response to pheromone (GO:0019236)3.07768564
48negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93642034
49detection of chemical stimulus involved in sensory perception (GO:0050907)2.91956768
50regulation of bile acid biosynthetic process (GO:0070857)2.90814832
51behavioral response to ethanol (GO:0048149)2.89841030
52response to histamine (GO:0034776)2.89160871
53sodium ion export (GO:0071436)2.87094833
54retinoid metabolic process (GO:0001523)2.86054091
55retinol metabolic process (GO:0042572)2.85604282
56negative regulation of transcription regulatory region DNA binding (GO:2000678)2.85486809
57potassium ion homeostasis (GO:0055075)2.83939290
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.81417597
59regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78734776
60membrane hyperpolarization (GO:0060081)2.78127129
61positive regulation of sodium ion transmembrane transport (GO:1902307)2.77615140
62diterpenoid metabolic process (GO:0016101)2.72921412
63positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.70889050
64short-term memory (GO:0007614)2.67235759
65CDP-diacylglycerol biosynthetic process (GO:0016024)2.66918693
66lipoprotein transport (GO:0042953)2.64057591
67behavioral response to cocaine (GO:0048148)2.61335820
68detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.58906953
69lactate metabolic process (GO:0006089)2.58013149
70terpenoid metabolic process (GO:0006721)2.55927811
71positive regulation of neurotransmitter transport (GO:0051590)2.49162909
72regulation of penile erection (GO:0060405)2.48792428
73positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.46232724
74CDP-diacylglycerol metabolic process (GO:0046341)2.46092496
75striatum development (GO:0021756)2.45351320
76G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42391370
77chemosensory behavior (GO:0007635)2.35568287
78synaptic vesicle maturation (GO:0016188)2.35272524
79regulation of neurotransmitter uptake (GO:0051580)2.32790294
80response to radiation (GO:0009314)2.32136387
81synaptic vesicle docking involved in exocytosis (GO:0016081)2.30603757
82synaptic transmission, dopaminergic (GO:0001963)2.27130491
83response to leptin (GO:0044321)2.26993425
84axoneme assembly (GO:0035082)2.26833607
85phospholipid translocation (GO:0045332)2.26644134
86lipid translocation (GO:0034204)2.26644134
87cellular response to leptin stimulus (GO:0044320)2.22559257
88positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.20709655
89mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.20709655
90fatty acid elongation (GO:0030497)2.20593131
91icosanoid secretion (GO:0032309)2.19865237
92regulation of rhodopsin mediated signaling pathway (GO:0022400)15.8429821
93rhodopsin mediated signaling pathway (GO:0016056)15.5157562
94retinal cone cell development (GO:0046549)13.5627915
95detection of light stimulus involved in sensory perception (GO:0050962)11.6955423
96detection of light stimulus involved in visual perception (GO:0050908)11.6955423
97photoreceptor cell development (GO:0042461)11.3554490
98eye photoreceptor cell development (GO:0042462)10.9290783
99photoreceptor cell maintenance (GO:0045494)10.5466330
100retinal rod cell development (GO:0046548)10.1300209

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.66911559
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.24680809
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.07103222
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.90588232
5GBX2_23144817_ChIP-Seq_PC3_Human2.73202942
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.72789224
7VDR_22108803_ChIP-Seq_LS180_Human2.46116841
8DROSHA_22980978_ChIP-Seq_HELA_Human2.10699173
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05466894
10SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03347554
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.03036980
12LXR_22158963_ChIP-Seq_LIVER_Mouse1.92364296
13AR_21572438_ChIP-Seq_LNCaP_Human1.90221547
14PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82020705
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78337061
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.74309533
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72242376
18PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71085013
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.70979525
20P53_22127205_ChIP-Seq_FIBROBLAST_Human1.67427856
21SMAD3_21741376_ChIP-Seq_HESCs_Human1.65736514
22MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63192450
23* REST_21632747_ChIP-Seq_MESCs_Mouse1.62658072
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61186916
25IGF1R_20145208_ChIP-Seq_DFB_Human1.59205581
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.58496799
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.56417408
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53883055
29BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.53336220
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53061583
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49782232
32SMAD4_21799915_ChIP-Seq_A2780_Human1.42319361
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41469646
34MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40142096
35HTT_18923047_ChIP-ChIP_STHdh_Human1.38344108
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.38217386
37AR_19668381_ChIP-Seq_PC3_Human1.36457611
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36167194
39EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35496868
40NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.34848569
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33864640
42TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25130633
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.24824326
44CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23228649
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.22211183
46TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22122542
47STAT3_23295773_ChIP-Seq_U87_Human1.20001755
48EZH2_18974828_ChIP-Seq_MESCs_Mouse1.17493555
49RNF2_18974828_ChIP-Seq_MESCs_Mouse1.17493555
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17224824
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.15803617
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13059459
53RARB_27405468_Chip-Seq_BRAIN_Mouse1.12884831
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12713742
55SMAD4_21741376_ChIP-Seq_HESCs_Human1.12068219
56TBL1_22424771_ChIP-Seq_293T_Human1.11127497
57* CBP_21632823_ChIP-Seq_H3396_Human1.10861969
58P300_19829295_ChIP-Seq_ESCs_Human1.10207434
59RING1B_27294783_Chip-Seq_NPCs_Mouse1.10127225
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08711792
61CBP_20019798_ChIP-Seq_JUKART_Human1.08019998
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08019998
63BCAT_22108803_ChIP-Seq_LS180_Human1.07609359
64FOXA2_19822575_ChIP-Seq_HepG2_Human1.07598252
65NCOR_22424771_ChIP-Seq_293T_Human1.06646121
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.06487566
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06336051
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06251964
69CTCF_27219007_Chip-Seq_Bcells_Human1.05284652
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04040593
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03402194
72EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03335198
73KDM2B_26808549_Chip-Seq_K562_Human1.02457734
74EGR1_19032775_ChIP-ChIP_M12_Human1.01991657
75TCF4_23295773_ChIP-Seq_U87_Human1.01352271
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01175002
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01036528
78SMC4_20622854_ChIP-Seq_HELA_Human1.00816820
79JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99829488
80WDR5_24793694_ChIP-Seq_LNCAP_Human0.98819252
81PRDM14_20953172_ChIP-Seq_ESCs_Human0.98100418
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96013367
83EED_16625203_ChIP-ChIP_MESCs_Mouse0.94715457
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94031530
85PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93942156
86FLI1_21867929_ChIP-Seq_TH2_Mouse0.91268185
87GF1_26923725_Chip-Seq_HPCs_Mouse0.90866071
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88509030
89ER_23166858_ChIP-Seq_MCF-7_Human0.87455836
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86922465
91LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86416837
92BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86406747
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.85298712
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.84904216
95YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84348417
96AR_25329375_ChIP-Seq_VCAP_Human0.84071145
97MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83393783
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82815486
99ISL1_27105846_Chip-Seq_CPCs_Mouse0.82712912
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81584867

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation9.75804420
2MP0005551_abnormal_eye_electrophysiolog9.74212914
3MP0005253_abnormal_eye_physiology6.44179650
4MP0006072_abnormal_retinal_apoptosis6.30914974
5MP0003950_abnormal_plasma_membrane4.16268352
6MP0005195_abnormal_posterior_eye3.84865897
7MP0002090_abnormal_vision3.43272154
8MP0001324_abnormal_eye_pigmentation3.39831215
9MP0002638_abnormal_pupillary_reflex3.11727971
10MP0005391_vision/eye_phenotype3.11189479
11MP0002229_neurodegeneration2.42252554
12MP0001764_abnormal_homeostasis2.41600688
13MP0005423_abnormal_somatic_nervous2.16200227
14MP0002752_abnormal_somatic_nervous1.87331974
15MP0001502_abnormal_circadian_rhythm1.61550852
16MP0001984_abnormal_olfaction1.58878712
17MP0001986_abnormal_taste_sensitivity1.58368921
18MP0004019_abnormal_vitamin_homeostasis1.54235694
19MP0005365_abnormal_bile_salt1.51349584
20MP0005360_urolithiasis1.41175392
21MP0002139_abnormal_hepatobiliary_system1.32259091
22MP0004233_abnormal_muscle_weight1.27309954
23MP0002882_abnormal_neuron_morphology1.27127022
24MP0005085_abnormal_gallbladder_physiolo1.26748509
25MP0002653_abnormal_ependyma_morphology1.25367759
26MP0008875_abnormal_xenobiotic_pharmacok1.20392628
27MP0003252_abnormal_bile_duct1.04585315
28MP0006292_abnormal_olfactory_placode1.03580857
29MP0004782_abnormal_surfactant_physiolog1.03163499
30MP0005499_abnormal_olfactory_system0.97768423
31MP0005394_taste/olfaction_phenotype0.97768423
32MP0005197_abnormal_uvea_morphology0.95755151
33MP0008789_abnormal_olfactory_epithelium0.90484773
34MP0002332_abnormal_exercise_endurance0.87593053
35MP0005187_abnormal_penis_morphology0.87341178
36MP0004885_abnormal_endolymph0.84104677
37MP0010386_abnormal_urinary_bladder0.84063322
38MP0010329_abnormal_lipoprotein_level0.78236325
39MP0005248_abnormal_Harderian_gland0.77525339
40MP0001486_abnormal_startle_reflex0.74326282
41MP0002272_abnormal_nervous_system0.70491405
42MP0003634_abnormal_glial_cell0.70428955
43MP0002127_abnormal_cardiovascular_syste0.67924546
44MP0003868_abnormal_feces_composition0.63745627
45MP0009840_abnormal_foam_cell0.62331439
46MP0005376_homeostasis/metabolism_phenot0.58952935
47MP0010368_abnormal_lymphatic_system0.56199986
48MP0001286_abnormal_eye_development0.53312954
49MP0005595_abnormal_vascular_smooth0.52715041
50MP0002067_abnormal_sensory_capabilities0.52455592
51MP0009046_muscle_twitch0.50418961
52MP0002064_seizures0.49533463
53MP0009697_abnormal_copulation0.47327445
54MP0001963_abnormal_hearing_physiology0.46429166
55MP0002734_abnormal_mechanical_nocicepti0.46066553
56MP0003880_abnormal_central_pattern0.44974319
57MP0004036_abnormal_muscle_relaxation0.43925116
58MP0000631_abnormal_neuroendocrine_gland0.43835977
59MP0004270_analgesia0.42811042
60MP0004215_abnormal_myocardial_fiber0.41847913
61MP0005220_abnormal_exocrine_pancreas0.40827635
62MP0001346_abnormal_lacrimal_gland0.37893369
63MP0003635_abnormal_synaptic_transmissio0.37422971
64MP0002118_abnormal_lipid_homeostasis0.35615227
65MP0005319_abnormal_enzyme/_coenzyme0.35305850
66MP0004085_abnormal_heartbeat0.35226756
67MP0002063_abnormal_learning/memory/cond0.34151171
68MP0005670_abnormal_white_adipose0.34044638
69MP0002184_abnormal_innervation0.33650744
70MP0001666_abnormal_nutrient_absorption0.32487658
71MP0005620_abnormal_muscle_contractility0.32302165
72MP0002928_abnormal_bile_duct0.32193221
73MP0008775_abnormal_heart_ventricle0.31579393
74MP0002572_abnormal_emotion/affect_behav0.31118796
75MP0005332_abnormal_amino_acid0.31074369
76MP0003890_abnormal_embryonic-extraembry0.30971500
77MP0008004_abnormal_stomach_pH0.30685512
78MP0003195_calcinosis0.28173173
79MP0002697_abnormal_eye_size0.27946475
80MP0000609_abnormal_liver_physiology0.27906535
81MP0000026_abnormal_inner_ear0.27848681
82MP0001661_extended_life_span0.27706867
83MP0005084_abnormal_gallbladder_morpholo0.27532079
84MP0004043_abnormal_pH_regulation0.26662840
85MP0010030_abnormal_orbit_morphology0.26570527
86MP0000465_gastrointestinal_hemorrhage0.26417635
87MP0004924_abnormal_behavior0.25933439
88MP0005386_behavior/neurological_phenoty0.25933439
89MP0005646_abnormal_pituitary_gland0.25718670
90MP0000230_abnormal_systemic_arterial0.24412639
91MP0001968_abnormal_touch/_nociception0.24267620
92MP0009745_abnormal_behavioral_response0.24233633
93MP0002909_abnormal_adrenal_gland0.23129039
94MP0005334_abnormal_fat_pad0.22044573
95MP0003879_abnormal_hair_cell0.22023429
96MP0009764_decreased_sensitivity_to0.21888749
97MP0005266_abnormal_metabolism0.20436112
98MP0005535_abnormal_body_temperature0.20244547
99MP0004742_abnormal_vestibular_system0.19393682
100MP0004142_abnormal_muscle_tone0.19199302

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.45745195
2Chorioretinal atrophy (HP:0000533)8.95599101
3Pigmentary retinal degeneration (HP:0001146)8.95231462
4Central scotoma (HP:0000603)8.23985958
5Abnormality of macular pigmentation (HP:0008002)7.68894332
6Pendular nystagmus (HP:0012043)7.31629931
7Dyschromatopsia (HP:0007641)7.29137917
8Scotoma (HP:0000575)7.08506583
9Attenuation of retinal blood vessels (HP:0007843)7.02456204
10Decreased central vision (HP:0007663)6.56212210
11Abolished electroretinogram (ERG) (HP:0000550)6.41001853
12Type II diabetes mellitus (HP:0005978)5.42043121
13Photophobia (HP:0000613)5.37887567
14Keratoconus (HP:0000563)5.27766506
15Increased corneal curvature (HP:0100692)5.27766506
16Cone-rod dystrophy (HP:0000548)5.09065891
17Vitreoretinal degeneration (HP:0000655)5.05050543
18Severe visual impairment (HP:0001141)4.96107356
19Macular degeneration (HP:0000608)4.53156380
20Retinitis pigmentosa (HP:0000510)4.38311582
21Constricted visual fields (HP:0001133)4.09591049
22Choroideremia (HP:0001139)4.02505760
23Posterior subcapsular cataract (HP:0007787)4.01155174
24Decreased electroretinogram (ERG) amplitude (HP:0000654)3.60633998
25Progressive visual loss (HP:0000529)2.89359401
26Retinal atrophy (HP:0001105)2.76762061
27Gait imbalance (HP:0002141)2.58052132
28Congenital primary aphakia (HP:0007707)2.56630026
29Optic disc pallor (HP:0000543)2.55744219
30Subcapsular cataract (HP:0000523)2.50197848
31Wide nasal bridge (HP:0000431)2.33815180
32Nephrogenic diabetes insipidus (HP:0009806)2.31850200
33Medial flaring of the eyebrow (HP:0010747)2.22953620
34Congenital sensorineural hearing impairment (HP:0008527)2.22689318
35Poor coordination (HP:0002370)2.03737142
36Congenital stationary night blindness (HP:0007642)15.7344060
37Bony spicule pigmentary retinopathy (HP:0007737)11.1221408
38Abnormal rod and cone electroretinograms (HP:0008323)10.1026649
39Severe Myopia (HP:0011003)1.72954813
40Vaginal atresia (HP:0000148)1.69700303
41Genital tract atresia (HP:0001827)1.66252397
42Optic atrophy (HP:0000648)1.63028343
43Hypoplasia of the fovea (HP:0007750)1.60323604
44Aplasia/Hypoplasia of the fovea (HP:0008060)1.60323604
45True hermaphroditism (HP:0010459)1.58415709
46Epileptic encephalopathy (HP:0200134)1.54990574
47Febrile seizures (HP:0002373)1.53340292
48Abnormality of the fovea (HP:0000493)1.52834538
49Dysdiadochokinesis (HP:0002075)1.52284894
50Aplasia/Hypoplasia of the lens (HP:0008063)1.42070163
51Abnormal gallbladder physiology (HP:0012438)1.36018217
52Cholecystitis (HP:0001082)1.36018217
53Interstitial pulmonary disease (HP:0006530)1.35259127
54Septo-optic dysplasia (HP:0100842)1.33558243
55Pancreatic fibrosis (HP:0100732)1.33144220
56Polar cataract (HP:0010696)1.31314135
57Astigmatism (HP:0000483)1.29639530
58Horizontal nystagmus (HP:0000666)1.29377393
59Aplasia/Hypoplasia of the macula (HP:0008059)1.28013547
60Intrahepatic cholestasis (HP:0001406)1.20030472
61Aplasia/Hypoplasia affecting the retina (HP:0008061)1.17095150
62Aplasia/Hypoplasia of the tongue (HP:0010295)1.11277683
63Pancreatic cysts (HP:0001737)1.10267787
64Cerebellar dysplasia (HP:0007033)1.07555556
65Left ventricular hypertrophy (HP:0001712)1.03403824
66Cystic liver disease (HP:0006706)1.03046757
67Chorioretinal coloboma (HP:0000567)1.02311156
68Broad foot (HP:0001769)1.01157980
69Albinism (HP:0001022)0.98158844
70Specific learning disability (HP:0001328)0.97769755
71Decreased testicular size (HP:0008734)0.95904095
72Progressive cerebellar ataxia (HP:0002073)0.95680996
73Abnormality of monocarboxylic acid metabolism (HP:0010996)0.94991868
74Asthma (HP:0002099)0.93969952
75Recurrent sinusitis (HP:0011108)0.92664544
76Retinal detachment (HP:0000541)0.92020890
77Chronic hepatic failure (HP:0100626)0.90566517
78Deep venous thrombosis (HP:0002625)0.90368715
79Abnormality of aromatic amino acid family metabolism (HP:0004338)0.89864739
80Hyperlipoproteinemia (HP:0010980)0.88324851
81Truncal ataxia (HP:0002078)0.88285346
82Absence seizures (HP:0002121)0.87922357
83Partial agenesis of the corpus callosum (HP:0001338)0.82458992
84Prolonged QT interval (HP:0001657)0.82095587
85Prolonged partial thromboplastin time (HP:0003645)0.81525073
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.81374386
87Hypobetalipoproteinemia (HP:0003563)0.77975041
88Xanthomatosis (HP:0000991)0.77157459
89Hypoalphalipoproteinemia (HP:0003233)0.76781187
90EEG with generalized epileptiform discharges (HP:0011198)0.75241903
91Generalized myoclonic seizures (HP:0002123)0.74591720
92Abnormality of the lower motor neuron (HP:0002366)0.73572256
93Sclerocornea (HP:0000647)0.73035670
94Congenital hepatic fibrosis (HP:0002612)0.72773287
95Short foot (HP:0001773)0.72371882
96Furrowed tongue (HP:0000221)0.70918600
97Epileptiform EEG discharges (HP:0011182)0.70915455
98Hypolipoproteinemia (HP:0010981)0.70692621
99Molar tooth sign on MRI (HP:0002419)0.70085686
100Abnormality of midbrain morphology (HP:0002418)0.70085686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.55560571
2GRK18.40449783
3PINK13.40627808
4INSRR2.96810811
5IRAK22.45187926
6NEK11.86354029
7TAOK31.86147917
8AKT31.55354099
9SGK4941.51799553
10SGK2231.51799553
11ERBB31.42727458
12SIK21.29153871
13CAMK1D1.27195870
14SGK21.23681930
15MAPK71.22640735
16ADRBK11.20237822
17STK381.19742629
18MAPK121.19516198
19MARK11.18866866
20CAMK1G1.15944017
21BRD41.14527811
22PRKAA11.09323659
23PLK21.06645374
24PRKCZ1.05245101
25DYRK1A1.04910408
26SGK31.00896140
27ERBB20.98529051
28EPHA30.98484626
29HIPK20.94770677
30MAP3K40.94261641
31SIK10.92943224
32PAK60.92555609
33CDK30.92193373
34MAP3K70.88869489
35LATS10.87650631
36CAMK2D0.85177891
37ICK0.84862022
38STK38L0.84788931
39CSNK1D0.81105888
40TAOK20.77119078
41RPS6KA40.76734802
42FES0.72134937
43CCNB10.71911636
44PRPF4B0.70281523
45MAP3K100.69885816
46CAMKK10.66558442
47PRKACG0.65074641
48BMPR20.64459216
49PRKCB0.64156399
50PRKAA20.64149033
51TNK20.64050049
52PHKG10.62353448
53PHKG20.62353448
54PLK40.61297287
55NEK60.60283156
56CDK90.59458237
57DYRK1B0.58478777
58PRKCH0.58195428
59RPS6KA30.55019464
60NEK20.53734129
61PRKD30.52409580
62RIPK10.47041325
63MAP3K130.46930989
64PKN10.46171932
65MINK10.45894964
66CAMK10.44607912
67MAP2K40.43645693
68CAMK40.43527549
69CAMK2A0.43054720
70PRKCG0.42849439
71GSK3B0.42729546
72CDK120.42549404
73SGK10.41828172
74PRKACA0.38317402
75NME10.38107210
76MAP2K70.37207402
77PRKCA0.37061389
78PLK30.36841870
79MAPK140.36671200
80MAPK100.35611860
81GRK50.35054775
82RPS6KB10.33971135
83PRKDC0.33811409
84CDK50.33601867
85MAPK90.33491859
86EPHA40.32346692
87FER0.28885978
88FRK0.26724729
89BCKDK0.26665103
90PRKG10.26612214
91TTK0.25700299
92AKT20.25635377
93CDK10.25213572
94PKN20.23779282
95YES10.23579550
96MAPK80.23492670
97MAPK30.23168638
98PRKD20.22984598
99FGFR40.22584909
100WNK10.21178510

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa0474414.6003452
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.80071328
3Synaptic vesicle cycle_Homo sapiens_hsa047211.71605342
4Olfactory transduction_Homo sapiens_hsa047401.52502141
5GABAergic synapse_Homo sapiens_hsa047271.52445137
6Retinol metabolism_Homo sapiens_hsa008301.47824533
7Circadian rhythm_Homo sapiens_hsa047101.35027339
8Primary bile acid biosynthesis_Homo sapiens_hsa001201.23142623
9Nitrogen metabolism_Homo sapiens_hsa009101.22999041
10Arginine biosynthesis_Homo sapiens_hsa002201.19454854
11Morphine addiction_Homo sapiens_hsa050321.04264674
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01304490
13ABC transporters_Homo sapiens_hsa020101.00920702
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95041306
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92742579
16Caffeine metabolism_Homo sapiens_hsa002320.87625801
17Circadian entrainment_Homo sapiens_hsa047130.86466682
18Cholinergic synapse_Homo sapiens_hsa047250.82061495
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79016066
20Fructose and mannose metabolism_Homo sapiens_hsa000510.78159214
21Nicotine addiction_Homo sapiens_hsa050330.76171728
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75068816
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74521273
24Drug metabolism - other enzymes_Homo sapiens_hsa009830.74110681
25Biosynthesis of amino acids_Homo sapiens_hsa012300.73169065
26Glutamatergic synapse_Homo sapiens_hsa047240.71726791
27Insulin secretion_Homo sapiens_hsa049110.62065955
28Serotonergic synapse_Homo sapiens_hsa047260.61226453
29Complement and coagulation cascades_Homo sapiens_hsa046100.60321985
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59977320
31Dopaminergic synapse_Homo sapiens_hsa047280.59261121
32Bile secretion_Homo sapiens_hsa049760.58325464
33Tryptophan metabolism_Homo sapiens_hsa003800.55615888
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53461397
35Fatty acid degradation_Homo sapiens_hsa000710.50055640
36Fatty acid elongation_Homo sapiens_hsa000620.49459856
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48456655
38cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48067173
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47859778
40Peroxisome_Homo sapiens_hsa041460.47772488
41Phenylalanine metabolism_Homo sapiens_hsa003600.47030622
42Glycerolipid metabolism_Homo sapiens_hsa005610.47002147
43Maturity onset diabetes of the young_Homo sapiens_hsa049500.45734865
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44190548
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43876995
46Lysine degradation_Homo sapiens_hsa003100.42812854
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.42719604
48Galactose metabolism_Homo sapiens_hsa000520.42697661
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40144798
50Renin secretion_Homo sapiens_hsa049240.40065231
51PPAR signaling pathway_Homo sapiens_hsa033200.39621336
52Pyruvate metabolism_Homo sapiens_hsa006200.38317149
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38080320
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37478507
55Fatty acid metabolism_Homo sapiens_hsa012120.36848458
56Carbon metabolism_Homo sapiens_hsa012000.36584299
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.36031962
58Butanoate metabolism_Homo sapiens_hsa006500.35960308
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35434283
60Fat digestion and absorption_Homo sapiens_hsa049750.35317160
61Purine metabolism_Homo sapiens_hsa002300.35162147
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34493481
63Oxytocin signaling pathway_Homo sapiens_hsa049210.34119032
64Starch and sucrose metabolism_Homo sapiens_hsa005000.34048765
65Salivary secretion_Homo sapiens_hsa049700.33081403
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32094956
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.31926130
68Pentose phosphate pathway_Homo sapiens_hsa000300.31296678
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.31275627
70Chemical carcinogenesis_Homo sapiens_hsa052040.30738566
71Vitamin digestion and absorption_Homo sapiens_hsa049770.30671417
72Tyrosine metabolism_Homo sapiens_hsa003500.30327519
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27482646
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27218053
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26859049
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25705241
77Dilated cardiomyopathy_Homo sapiens_hsa054140.25658296
78Cardiac muscle contraction_Homo sapiens_hsa042600.24890762
79Histidine metabolism_Homo sapiens_hsa003400.24329656
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23751145
81Linoleic acid metabolism_Homo sapiens_hsa005910.23508098
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23500594
83Inositol phosphate metabolism_Homo sapiens_hsa005620.23305788
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22214124
85cAMP signaling pathway_Homo sapiens_hsa040240.21528063
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21273943
87beta-Alanine metabolism_Homo sapiens_hsa004100.20917658
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20503455
89Type II diabetes mellitus_Homo sapiens_hsa049300.20381474
90Propanoate metabolism_Homo sapiens_hsa006400.20210347
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19376263
92mTOR signaling pathway_Homo sapiens_hsa041500.18985674
93Mineral absorption_Homo sapiens_hsa049780.18921534
94Glucagon signaling pathway_Homo sapiens_hsa049220.18631723
95Arginine and proline metabolism_Homo sapiens_hsa003300.18294563
96Staphylococcus aureus infection_Homo sapiens_hsa051500.18190414
97Folate biosynthesis_Homo sapiens_hsa007900.15492109
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14805993
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.14575867
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14412051

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