LRIG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.61385238
2negative regulation of translation, ncRNA-mediated (GO:0040033)4.61385238
3regulation of translation, ncRNA-mediated (GO:0045974)4.61385238
4behavioral response to nicotine (GO:0035095)4.60511146
5cell migration in hindbrain (GO:0021535)3.73549901
6protein K11-linked deubiquitination (GO:0035871)3.70339579
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.67653094
8fucose catabolic process (GO:0019317)3.67474456
9L-fucose metabolic process (GO:0042354)3.67474456
10L-fucose catabolic process (GO:0042355)3.67474456
11neural tube formation (GO:0001841)3.66418264
12regulation of posttranscriptional gene silencing (GO:0060147)3.62527456
13regulation of gene silencing by miRNA (GO:0060964)3.62527456
14regulation of gene silencing by RNA (GO:0060966)3.62527456
15regulation of short-term neuronal synaptic plasticity (GO:0048172)3.55477218
16regulation of synaptic vesicle exocytosis (GO:2000300)3.52753395
17axonal fasciculation (GO:0007413)3.49333732
18neuron cell-cell adhesion (GO:0007158)3.37754292
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37017655
20regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.35376635
21locomotory exploration behavior (GO:0035641)3.35275079
22regulation of hippo signaling (GO:0035330)3.28562165
23negative regulation of cytosolic calcium ion concentration (GO:0051481)3.27171597
24vocalization behavior (GO:0071625)3.25394178
25indolalkylamine metabolic process (GO:0006586)3.25036976
26kidney morphogenesis (GO:0060993)3.20016658
27regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.18428211
28negative regulation of dendrite morphogenesis (GO:0050774)3.17520227
29presynaptic membrane assembly (GO:0097105)3.16803211
30indole-containing compound catabolic process (GO:0042436)3.15648941
31indolalkylamine catabolic process (GO:0046218)3.15648941
32tryptophan catabolic process (GO:0006569)3.15648941
33cerebellar Purkinje cell differentiation (GO:0021702)3.12940752
34regulation of glutamate receptor signaling pathway (GO:1900449)3.12656279
35interkinetic nuclear migration (GO:0022027)3.09585710
36detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08805605
37kynurenine metabolic process (GO:0070189)3.07846216
38atrial cardiac muscle cell action potential (GO:0086014)3.05876704
39neuron recognition (GO:0008038)3.05730840
40establishment of protein localization to Golgi (GO:0072600)3.05542155
41presynaptic membrane organization (GO:0097090)3.04729208
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.02837090
43protein localization to synapse (GO:0035418)3.01698014
44pyrimidine nucleobase catabolic process (GO:0006208)3.00108894
45regulation of synaptic vesicle transport (GO:1902803)2.99076218
46neurotransmitter-gated ion channel clustering (GO:0072578)2.95208535
47central nervous system projection neuron axonogenesis (GO:0021952)2.94310521
48nonmotile primary cilium assembly (GO:0035058)2.94114663
49synaptic vesicle maturation (GO:0016188)2.93453548
50regulation of nuclear cell cycle DNA replication (GO:0033262)2.92793380
51positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92540618
52rRNA catabolic process (GO:0016075)2.90963355
53negative regulation of dendrite development (GO:2000171)2.90891204
54synaptic vesicle docking involved in exocytosis (GO:0016081)2.90784641
55photoreceptor cell maintenance (GO:0045494)2.88063805
56reflex (GO:0060004)2.86512622
57tryptophan metabolic process (GO:0006568)2.85833322
58synaptic vesicle exocytosis (GO:0016079)2.84964533
59protein prenylation (GO:0018342)2.82245510
60prenylation (GO:0097354)2.82245510
61cerebral cortex radially oriented cell migration (GO:0021799)2.82029614
62histone H3-K9 methylation (GO:0051567)2.82021061
63positive regulation of developmental pigmentation (GO:0048087)2.80640728
64dendrite morphogenesis (GO:0048813)2.80348307
65neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.80217282
66* innervation (GO:0060384)2.79785487
67retinal cone cell development (GO:0046549)2.78167692
68regulation of telomere maintenance (GO:0032204)2.77296897
69exploration behavior (GO:0035640)2.76095988
70protein K48-linked deubiquitination (GO:0071108)2.74328690
71cAMP catabolic process (GO:0006198)2.72800628
72synaptic vesicle endocytosis (GO:0048488)2.72524566
73axoneme assembly (GO:0035082)2.71766302
74ionotropic glutamate receptor signaling pathway (GO:0035235)2.69505725
75monoubiquitinated protein deubiquitination (GO:0035520)2.68981326
76postsynaptic membrane organization (GO:0001941)2.68497909
77cellular response to sterol (GO:0036315)2.68375511
78cornea development in camera-type eye (GO:0061303)2.67667933
79negative regulation of DNA-dependent DNA replication (GO:2000104)2.67571042
80inner ear receptor stereocilium organization (GO:0060122)2.67497453
81regulation of pigment cell differentiation (GO:0050932)2.65723235
82cytoplasmic mRNA processing body assembly (GO:0033962)2.65293573
83membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64754772
84microtubule anchoring (GO:0034453)2.64311541
85regulation of synaptic transmission, GABAergic (GO:0032228)2.64060470
86proline transport (GO:0015824)2.63844495
87protein K63-linked deubiquitination (GO:0070536)2.63672669
88ncRNA catabolic process (GO:0034661)2.63342335
89thyroid hormone metabolic process (GO:0042403)2.62694439
90reciprocal meiotic recombination (GO:0007131)2.62691522
91reciprocal DNA recombination (GO:0035825)2.62691522
92somite development (GO:0061053)2.61994373
93glutamate receptor signaling pathway (GO:0007215)2.61782805
94regulation of NFAT protein import into nucleus (GO:0051532)2.61604981
95detection of light stimulus involved in sensory perception (GO:0050962)2.61329191
96detection of light stimulus involved in visual perception (GO:0050908)2.61329191
97glutamate secretion (GO:0014047)2.61147673
98synaptic transmission, glutamatergic (GO:0035249)2.59538659
99long-term memory (GO:0007616)2.58895218
100membrane depolarization during action potential (GO:0086010)2.58410724
101neuronal action potential propagation (GO:0019227)2.57499631
102RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57489595
103head development (GO:0060322)2.57396945
104replicative senescence (GO:0090399)2.57157674
105regulation of neuronal synaptic plasticity (GO:0048168)2.56891303
106long-term synaptic potentiation (GO:0060291)2.56862390
107double-strand break repair via homologous recombination (GO:0000724)2.56577192
108layer formation in cerebral cortex (GO:0021819)2.56120535
109positive regulation of synaptic transmission, GABAergic (GO:0032230)2.55428373
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54526240
111recombinational repair (GO:0000725)2.54338086
112neuronal ion channel clustering (GO:0045161)2.54161266
113dendritic spine morphogenesis (GO:0060997)2.53411097
114nucleobase catabolic process (GO:0046113)2.52182666
115peripheral nervous system neuron development (GO:0048935)2.52170094
116negative regulation of neurotransmitter secretion (GO:0046929)2.51728174
117cyclic nucleotide catabolic process (GO:0009214)2.50921668
118neuron-neuron synaptic transmission (GO:0007270)2.50293781
119inositol phosphate catabolic process (GO:0071545)2.50126288
120cilium morphogenesis (GO:0060271)2.49971026
121positive regulation of synapse maturation (GO:0090129)2.49747565
122regulation of postsynaptic membrane potential (GO:0060078)2.49693102
123behavioral defense response (GO:0002209)2.49372355
124behavioral fear response (GO:0001662)2.49372355
125replication fork processing (GO:0031297)2.48965555
126central nervous system neuron axonogenesis (GO:0021955)2.48581045
127regulation of excitatory postsynaptic membrane potential (GO:0060079)2.48134092
128establishment of nucleus localization (GO:0040023)2.47869905
129vesicle transport along microtubule (GO:0047496)2.47401477
130regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46635310
131epithelial cilium movement (GO:0003351)2.46460250
132negative regulation of systemic arterial blood pressure (GO:0003085)2.44804891
133cilium organization (GO:0044782)2.44608418
134auditory receptor cell stereocilium organization (GO:0060088)2.44515932
135neuronal action potential (GO:0019228)2.44235191
136negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.42595514
137regulation of synaptic transmission, glutamatergic (GO:0051966)2.42436371
138sulfation (GO:0051923)2.42224110
139nerve growth factor signaling pathway (GO:0038180)2.41607635
140regulation of neurotransmitter secretion (GO:0046928)2.41418070
141G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39946590
142cilium assembly (GO:0042384)2.39398891
143positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39083689
144regulation of synapse maturation (GO:0090128)2.38759224
145rhodopsin mediated signaling pathway (GO:0016056)2.38732118
146L-amino acid import (GO:0043092)2.38608205
147DNA double-strand break processing (GO:0000729)2.37976033
148eye photoreceptor cell development (GO:0042462)2.36129766
149protein targeting to Golgi (GO:0000042)2.35133473
150snRNA transcription (GO:0009301)2.35124526
151protein localization to cilium (GO:0061512)2.34406750
152prostate gland growth (GO:0060736)2.33673728
153regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.32913656
154gamma-aminobutyric acid transport (GO:0015812)2.32830440
155fear response (GO:0042596)2.32535804
156regulation of meiosis I (GO:0060631)2.32313124
157spinal cord motor neuron differentiation (GO:0021522)2.32210087
158somite rostral/caudal axis specification (GO:0032525)2.32170129
159photoreceptor cell development (GO:0042461)2.31224952
160regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.30959741
161cilium or flagellum-dependent cell motility (GO:0001539)2.30336545
162axon extension (GO:0048675)2.30126355
163neurotransmitter secretion (GO:0007269)2.29991872
164negative regulation of neurotransmitter transport (GO:0051589)2.29908883
165dendrite development (GO:0016358)2.29779048
166regulation of mesoderm development (GO:2000380)2.29479466
167regulation of long-term neuronal synaptic plasticity (GO:0048169)2.29124627
168embryonic epithelial tube formation (GO:0001838)2.29063393
169synapse assembly (GO:0007416)2.28840196
170limb development (GO:0060173)2.28835249
171appendage development (GO:0048736)2.28835249
172regulation of non-canonical Wnt signaling pathway (GO:2000050)2.28690568
173regulation of action potential (GO:0098900)2.28505794
174indole-containing compound metabolic process (GO:0042430)2.28173746
175regulation of dendritic spine morphogenesis (GO:0061001)2.27799207
176regulation of glycogen (starch) synthase activity (GO:2000465)2.27339523
177behavioral response to ethanol (GO:0048149)2.26966360
178positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.26629911
179limb bud formation (GO:0060174)2.26560958
180cell proliferation in forebrain (GO:0021846)2.26462301
181startle response (GO:0001964)2.26453538
182positive regulation of membrane potential (GO:0045838)2.26181957
183glial cell proliferation (GO:0014009)2.25776152
184piRNA metabolic process (GO:0034587)2.25700832
185organelle transport along microtubule (GO:0072384)2.25686684
186sympathetic nervous system development (GO:0048485)2.25237814
187gene silencing by RNA (GO:0031047)2.25197560
188membrane hyperpolarization (GO:0060081)2.25051350
189response to pheromone (GO:0019236)2.22973336
190regulation of voltage-gated calcium channel activity (GO:1901385)2.21677627
191retina layer formation (GO:0010842)2.21219901
192positive regulation of muscle hypertrophy (GO:0014742)2.20615845
193positive regulation of cardiac muscle hypertrophy (GO:0010613)2.20615845
194membrane depolarization (GO:0051899)2.20470880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.40094440
2GBX2_23144817_ChIP-Seq_PC3_Human3.76518940
3VDR_22108803_ChIP-Seq_LS180_Human2.78989317
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.58600220
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20672316
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15536148
7SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15364960
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05795584
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05174997
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.05078133
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.01447650
12SMAD_19615063_ChIP-ChIP_OVARY_Human1.99105487
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95338160
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94463966
15* SMAD4_21799915_ChIP-Seq_A2780_Human1.94079399
16EED_16625203_ChIP-ChIP_MESCs_Mouse1.90619495
17PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90288859
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.88300084
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.88300084
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.86498614
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84604225
22AR_21572438_ChIP-Seq_LNCaP_Human1.83758263
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.83365570
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83361104
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81997757
26* P300_19829295_ChIP-Seq_ESCs_Human1.78599768
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76781888
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.76243882
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.75227248
30IGF1R_20145208_ChIP-Seq_DFB_Human1.74499843
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69925898
32DROSHA_22980978_ChIP-Seq_HELA_Human1.68425374
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66917800
34REST_21632747_ChIP-Seq_MESCs_Mouse1.66856079
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.66439790
36TAF15_26573619_Chip-Seq_HEK293_Human1.64840987
37NOTCH1_21737748_ChIP-Seq_TLL_Human1.61751403
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60918069
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60344881
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59383334
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59136204
42STAT3_23295773_ChIP-Seq_U87_Human1.58277133
43CBP_20019798_ChIP-Seq_JUKART_Human1.55816871
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.55816871
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55549408
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.55123316
47IRF1_19129219_ChIP-ChIP_H3396_Human1.52568744
48FUS_26573619_Chip-Seq_HEK293_Human1.52373491
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48498252
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.48412086
51RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48243345
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.47119580
53* BCAT_22108803_ChIP-Seq_LS180_Human1.46717244
54RNF2_27304074_Chip-Seq_NSC_Mouse1.46552154
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45821761
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.45019861
57* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44903194
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44053628
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43859788
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43859788
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42860352
62TP53_16413492_ChIP-PET_HCT116_Human1.42194054
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41756154
64* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40057880
65* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39901787
66TCF4_23295773_ChIP-Seq_U87_Human1.39790465
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39331181
68AR_25329375_ChIP-Seq_VCAP_Human1.38471320
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38178199
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38062061
71ZNF274_21170338_ChIP-Seq_K562_Hela1.37345155
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36616367
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36000904
74AHR_22903824_ChIP-Seq_MCF-7_Human1.35644465
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.35600170
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35267592
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.34613624
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.34191597
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34094252
80* NANOG_18555785_Chip-Seq_ESCs_Mouse1.32094020
81CBX2_27304074_Chip-Seq_ESCs_Mouse1.31894957
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.31459974
83* TCF4_22108803_ChIP-Seq_LS180_Human1.29714168
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.28251669
85* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27383630
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26864450
87HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.26091310
88AR_19668381_ChIP-Seq_PC3_Human1.25530571
89* E2F1_18555785_Chip-Seq_ESCs_Mouse1.24648823
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24570591
91* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23525246
92ER_23166858_ChIP-Seq_MCF-7_Human1.21308434
93CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20547577
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20476788
95NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19662243
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19328352
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.19300489
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.19251889
99NFE2_27457419_Chip-Seq_LIVER_Mouse1.18899800
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.18627723
101REST_18959480_ChIP-ChIP_MESCs_Mouse1.16932329
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15814886
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13242307
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12459941
105* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12258344
106* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11568771
107TP53_18474530_ChIP-ChIP_U2OS_Human1.11283661
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11010624
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.10555115
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10449779
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09654129
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.09409236
113* EWS_26573619_Chip-Seq_HEK293_Human1.08201209
114TP53_22573176_ChIP-Seq_HFKS_Human1.07767870
115WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07698183
116* CMYC_18555785_Chip-Seq_ESCs_Mouse1.06663073
117* NANOG_19829295_ChIP-Seq_ESCs_Human1.06499824
118* SOX2_19829295_ChIP-Seq_ESCs_Human1.06499824
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05784492
120STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04682142
121SMAD3_21741376_ChIP-Seq_ESCs_Human1.04540494
122* SMAD4_21741376_ChIP-Seq_EPCs_Human1.04386447
123RXR_22108803_ChIP-Seq_LS180_Human1.04281150
124FLI1_27457419_Chip-Seq_LIVER_Mouse1.04130848
125TCF4_18268006_ChIP-ChIP_LS174T_Human1.03959326
126CTNNB1_20460455_ChIP-Seq_HCT116_Human1.03857596
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03470699
128* P53_22387025_ChIP-Seq_ESCs_Mouse1.03358540
129PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03202352
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.03077459
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.02871937
132* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02735010
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01852099
134* CDX2_22108803_ChIP-Seq_LS180_Human1.01209720
135KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01137877
136* TBL1_22424771_ChIP-Seq_293T_Human0.97386678
137CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96680328
138KDM2B_26808549_Chip-Seq_REH_Human0.95854803
139MYC_18940864_ChIP-ChIP_HL60_Human0.95371365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.69718574
2MP0002735_abnormal_chemical_nociception3.24086484
3MP0004270_analgesia2.87805075
4MP0003880_abnormal_central_pattern2.84733609
5MP0008057_abnormal_DNA_replication2.73106426
6MP0003635_abnormal_synaptic_transmissio2.61177569
7MP0003122_maternal_imprinting2.48950072
8MP0005423_abnormal_somatic_nervous2.46190633
9MP0003646_muscle_fatigue2.45006998
10MP0003787_abnormal_imprinting2.43655737
11MP0001968_abnormal_touch/_nociception2.43139192
12MP0009046_muscle_twitch2.32839347
13MP0005646_abnormal_pituitary_gland2.28032431
14MP0000569_abnormal_digit_pigmentation2.27567817
15MP0001188_hyperpigmentation2.27545691
16MP0002734_abnormal_mechanical_nocicepti2.27534181
17MP0000778_abnormal_nervous_system2.27091200
18MP0003195_calcinosis2.25124301
19MP0002063_abnormal_learning/memory/cond2.19505208
20MP0004043_abnormal_pH_regulation2.17255577
21MP0002102_abnormal_ear_morphology2.14912001
22MP0004858_abnormal_nervous_system2.12328170
23MP0009745_abnormal_behavioral_response2.05020034
24MP0009780_abnormal_chondrocyte_physiolo2.03977931
25MP0006276_abnormal_autonomic_nervous2.00480873
26MP0002184_abnormal_innervation1.99316837
27MP0002064_seizures1.95545420
28MP0001486_abnormal_startle_reflex1.93075559
29MP0001986_abnormal_taste_sensitivity1.91882654
30MP0002572_abnormal_emotion/affect_behav1.91107335
31MP0002272_abnormal_nervous_system1.90588299
32MP0000427_abnormal_hair_cycle1.85865610
33MP0003121_genomic_imprinting1.85661622
34MP0002736_abnormal_nociception_after1.84784313
35MP0005551_abnormal_eye_electrophysiolog1.79123275
36MP0000383_abnormal_hair_follicle1.77649679
37MP0006292_abnormal_olfactory_placode1.73318256
38MP0002067_abnormal_sensory_capabilities1.73191721
39MP0005409_darkened_coat_color1.69468647
40MP0005645_abnormal_hypothalamus_physiol1.69428983
41MP0003937_abnormal_limbs/digits/tail_de1.67236814
42MP0005174_abnormal_tail_pigmentation1.57427097
43MP0002733_abnormal_thermal_nociception1.56865753
44MP0004885_abnormal_endolymph1.56516901
45MP0005171_absent_coat_pigmentation1.56436712
46MP0002837_dystrophic_cardiac_calcinosis1.55472863
47MP0002557_abnormal_social/conspecific_i1.52105679
48MP0003136_yellow_coat_color1.51990648
49MP0003183_abnormal_peptide_metabolism1.51392695
50MP0000955_abnormal_spinal_cord1.49556687
51MP0001970_abnormal_pain_threshold1.49502119
52MP0002876_abnormal_thyroid_physiology1.48610594
53MP0004811_abnormal_neuron_physiology1.45447454
54MP0002938_white_spotting1.44496980
55MP0002882_abnormal_neuron_morphology1.44069237
56MP0004133_heterotaxia1.41569458
57MP0005386_behavior/neurological_phenoty1.39290433
58MP0004924_abnormal_behavior1.39290433
59MP0008569_lethality_at_weaning1.38749370
60MP0001502_abnormal_circadian_rhythm1.37224301
61MP0005253_abnormal_eye_physiology1.35334421
62MP0010386_abnormal_urinary_bladder1.34653068
63MP0000631_abnormal_neuroendocrine_gland1.34029414
64MP0001485_abnormal_pinna_reflex1.33372474
65MP0001984_abnormal_olfaction1.32414223
66MP0001440_abnormal_grooming_behavior1.29986611
67MP0005187_abnormal_penis_morphology1.29891079
68MP0002160_abnormal_reproductive_system1.25710394
69MP0003119_abnormal_digestive_system1.24158959
70MP0001299_abnormal_eye_distance/1.23179816
71MP0008058_abnormal_DNA_repair1.22305615
72MP0002653_abnormal_ependyma_morphology1.20777935
73MP0001177_atelectasis1.17409404
74MP0004130_abnormal_muscle_cell1.15853737
75MP0001293_anophthalmia1.14980073
76MP0009697_abnormal_copulation1.14626216
77MP0008877_abnormal_DNA_methylation1.13014692
78MP0002152_abnormal_brain_morphology1.12145687
79MP0003633_abnormal_nervous_system1.10496097
80MP0002822_catalepsy1.09603551
81MP0004215_abnormal_myocardial_fiber1.09546702
82MP0003890_abnormal_embryonic-extraembry1.09081812
83MP0002752_abnormal_somatic_nervous1.07952138
84MP0010678_abnormal_skin_adnexa1.06875521
85MP0006072_abnormal_retinal_apoptosis1.05632194
86MP0000015_abnormal_ear_pigmentation1.05383286
87MP0002928_abnormal_bile_duct1.05326265
88MP0004742_abnormal_vestibular_system1.04948911
89MP0003567_abnormal_fetal_cardiomyocyte1.04218180
90MP0002229_neurodegeneration1.03959184
91MP0003718_maternal_effect1.03324883
92MP0003631_nervous_system_phenotype1.02212617
93MP0005389_reproductive_system_phenotype1.01998527
94MP0008872_abnormal_physiological_respon1.01773601
95MP0002751_abnormal_autonomic_nervous1.00802846
96MP0002066_abnormal_motor_capabilities/c1.00083884
97MP0003045_fibrosis0.96136426
98MP0008995_early_reproductive_senescence0.95002384
99MP0004084_abnormal_cardiac_muscle0.94622378
100MP0004147_increased_porphyrin_level0.93424310
101MP0000647_abnormal_sebaceous_gland0.93397278
102MP0002233_abnormal_nose_morphology0.93162294
103MP0008961_abnormal_basal_metabolism0.91532349
104MP0004142_abnormal_muscle_tone0.90600463
105MP0002095_abnormal_skin_pigmentation0.90423368
106MP0003634_abnormal_glial_cell0.89374788
107MP0008775_abnormal_heart_ventricle0.89268474
108MP0003632_abnormal_nervous_system0.88922589
109MP0004233_abnormal_muscle_weight0.88499406
110MP0001963_abnormal_hearing_physiology0.88259597
111MP0003283_abnormal_digestive_organ0.88009022
112MP0003861_abnormal_nervous_system0.86929457
113MP0001286_abnormal_eye_development0.86287843
114MP0008789_abnormal_olfactory_epithelium0.85838703
115MP0002234_abnormal_pharynx_morphology0.85530430
116MP0003385_abnormal_body_wall0.85186798
117MP0002009_preneoplasia0.85093171
118MP0000566_synostosis0.84398178
119MP0005195_abnormal_posterior_eye0.82574726
120MP0003950_abnormal_plasma_membrane0.82568385
121MP0001919_abnormal_reproductive_system0.81219730
122MP0000372_irregular_coat_pigmentation0.79496901
123MP0002638_abnormal_pupillary_reflex0.78419645
124MP0003698_abnormal_male_reproductive0.78220038
125MP0004484_altered_response_of0.77221157
126MP0000049_abnormal_middle_ear0.77167439
127MP0004145_abnormal_muscle_electrophysio0.76338088
128MP0003942_abnormal_urinary_system0.76061958
129MP0002108_abnormal_muscle_morphology0.76039636
130MP0005499_abnormal_olfactory_system0.76012293
131MP0005394_taste/olfaction_phenotype0.76012293
132MP0003137_abnormal_impulse_conducting0.74688820
133MP0003755_abnormal_palate_morphology0.73628879
134MP0000516_abnormal_urinary_system0.73446588
135MP0005367_renal/urinary_system_phenotyp0.73446588
136MP0005167_abnormal_blood-brain_barrier0.71955754
137MP0000428_abnormal_craniofacial_morphol0.70753097
138MP0003935_abnormal_craniofacial_develop0.68911065
139MP0003943_abnormal_hepatobiliary_system0.68696865
140MP0000920_abnormal_myelination0.66836706
141MP0004085_abnormal_heartbeat0.66667059
142MP0001324_abnormal_eye_pigmentation0.66322442
143MP0003938_abnormal_ear_development0.65686850
144MP0000026_abnormal_inner_ear0.64884773
145MP0003123_paternal_imprinting0.64619078
146MP0005391_vision/eye_phenotype0.64386905
147MP0000751_myopathy0.64047659
148MP0001501_abnormal_sleep_pattern0.63117551

Predicted human phenotypes

RankGene SetZ-score
1Febrile seizures (HP:0002373)4.22603714
2Pancreatic cysts (HP:0001737)4.17942725
3Focal motor seizures (HP:0011153)3.82680430
4Abnormal hair whorl (HP:0010721)3.68448218
5Pancreatic fibrosis (HP:0100732)3.58050603
6Chronic hepatic failure (HP:0100626)3.45587951
7True hermaphroditism (HP:0010459)3.43274716
8Nephronophthisis (HP:0000090)3.37465730
9Abnormality of midbrain morphology (HP:0002418)3.25204304
10Molar tooth sign on MRI (HP:0002419)3.25204304
11Protruding tongue (HP:0010808)3.19501398
12Abnormality of the renal medulla (HP:0100957)3.18256211
13Epileptic encephalopathy (HP:0200134)3.16311932
14Focal seizures (HP:0007359)3.08982708
15Abnormality of the renal cortex (HP:0011035)3.07303991
16Congenital stationary night blindness (HP:0007642)3.02627758
17Action tremor (HP:0002345)3.02292633
18Aqueductal stenosis (HP:0002410)2.97272334
19Atonic seizures (HP:0010819)2.92556568
20Progressive inability to walk (HP:0002505)2.83137966
21Progressive cerebellar ataxia (HP:0002073)2.82430583
22Type II lissencephaly (HP:0007260)2.71032503
23Abnormality of incisor morphology (HP:0011063)2.69527281
24Clumsiness (HP:0002312)2.68164624
25Inability to walk (HP:0002540)2.64116424
26Myokymia (HP:0002411)2.63254090
27Cystic liver disease (HP:0006706)2.62152240
28Fair hair (HP:0002286)2.58440510
29Medial flaring of the eyebrow (HP:0010747)2.53866970
30Cerebellar dysplasia (HP:0007033)2.44726986
31Attenuation of retinal blood vessels (HP:0007843)2.44394255
32Truncal ataxia (HP:0002078)2.41422212
33Tubular atrophy (HP:0000092)2.38023897
34Colon cancer (HP:0003003)2.36418451
35Stomach cancer (HP:0012126)2.33709689
36Abnormality of the nasal septum (HP:0000419)2.31616821
37Excessive salivation (HP:0003781)2.31097575
38Drooling (HP:0002307)2.31097575
39Urinary bladder sphincter dysfunction (HP:0002839)2.29983813
40Neoplasm of the adrenal cortex (HP:0100641)2.26996965
41Absent speech (HP:0001344)2.25233490
42Genetic anticipation (HP:0003743)2.24166665
43Insidious onset (HP:0003587)2.22103049
44Termporal pattern (HP:0011008)2.22103049
45Lissencephaly (HP:0001339)2.21647304
46Cupped ear (HP:0000378)2.18650070
47Gaze-evoked nystagmus (HP:0000640)2.18324700
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.18271284
49Abnormality of the corticospinal tract (HP:0002492)2.15594489
50Chorioretinal atrophy (HP:0000533)2.11624422
51Thyroiditis (HP:0100646)2.11246509
52Renal cortical cysts (HP:0000803)2.10800657
53Midline defect of the nose (HP:0004122)2.10726842
54Patellar aplasia (HP:0006443)2.09456932
55Abnormality of the labia minora (HP:0012880)2.08594302
56Intestinal atresia (HP:0011100)2.08260259
57Abnormality of the labia majora (HP:0012881)2.07947485
58Macroorchidism (HP:0000053)2.07457572
59Ankle clonus (HP:0011448)2.06788034
60Bile duct proliferation (HP:0001408)2.04656687
61Abnormal biliary tract physiology (HP:0012439)2.04656687
62Genital tract atresia (HP:0001827)2.04042769
63Scanning speech (HP:0002168)2.02735772
64Pendular nystagmus (HP:0012043)2.01515971
65Polydipsia (HP:0001959)1.99082341
66Abnormal drinking behavior (HP:0030082)1.99082341
67Vaginal atresia (HP:0000148)1.98988998
68Impaired vibration sensation in the lower limbs (HP:0002166)1.98705133
69Congenital primary aphakia (HP:0007707)1.97856003
70Aplasia/Hypoplasia of the tongue (HP:0010295)1.96997392
71Narrow nasal bridge (HP:0000446)1.96938463
72Sclerocornea (HP:0000647)1.95714399
73Aplasia involving bones of the upper limbs (HP:0009823)1.95190631
74Aplasia of the phalanges of the hand (HP:0009802)1.95190631
75Aplasia involving bones of the extremities (HP:0009825)1.95190631
76Aplasia/Hypoplasia of the uvula (HP:0010293)1.95084594
77Broad-based gait (HP:0002136)1.94707843
78Hyperventilation (HP:0002883)1.93729209
79Anencephaly (HP:0002323)1.92943892
80Absence seizures (HP:0002121)1.92842437
81Megalencephaly (HP:0001355)1.92242379
82Short 4th metacarpal (HP:0010044)1.92045650
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.92045650
84Aplasia/Hypoplasia of the patella (HP:0006498)1.91581512
85Widely spaced teeth (HP:0000687)1.91101711
86Poor coordination (HP:0002370)1.90923118
87Abnormality of the renal collecting system (HP:0004742)1.90911123
88Furrowed tongue (HP:0000221)1.90283367
89Urinary urgency (HP:0000012)1.89892813
90Degeneration of the lateral corticospinal tracts (HP:0002314)1.89758238
91Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89758238
92Generalized hypopigmentation of hair (HP:0011358)1.89323409
93Volvulus (HP:0002580)1.89273141
94Pheochromocytoma (HP:0002666)1.88248173
95Nephrogenic diabetes insipidus (HP:0009806)1.86787767
96Cutaneous finger syndactyly (HP:0010554)1.86039444
97Blue irides (HP:0000635)1.85972063
98Ectopic kidney (HP:0000086)1.82750448
99Postaxial foot polydactyly (HP:0001830)1.82695932
100Birth length less than 3rd percentile (HP:0003561)1.82637193
101Submucous cleft hard palate (HP:0000176)1.82143783
102Hypoplasia of the pons (HP:0012110)1.81216047
103Lower limb muscle weakness (HP:0007340)1.81046406
104Dialeptic seizures (HP:0011146)1.80589643
105Small hand (HP:0200055)1.80443247
106Abnormality of the pons (HP:0007361)1.80298176
107Abolished electroretinogram (ERG) (HP:0000550)1.79858085
108Bony spicule pigmentary retinopathy (HP:0007737)1.79730380
109Epileptiform EEG discharges (HP:0011182)1.79666599
110Duplicated collecting system (HP:0000081)1.78865414
111Congenital hepatic fibrosis (HP:0002612)1.78546466
112EEG with generalized epileptiform discharges (HP:0011198)1.76494736
113Abnormality of salivation (HP:0100755)1.76054632
114Abnormality of the ileum (HP:0001549)1.75583803
115Spastic gait (HP:0002064)1.75410483
116Dandy-Walker malformation (HP:0001305)1.74407186
117Large for gestational age (HP:0001520)1.74153549
118Fetal akinesia sequence (HP:0001989)1.73005113
119Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72085379
120Pachygyria (HP:0001302)1.71935045
121Narrow palate (HP:0000189)1.71416919
122Clubbing of toes (HP:0100760)1.71148036
123Preaxial hand polydactyly (HP:0001177)1.70956221
124Keratoconus (HP:0000563)1.70881742
125Increased corneal curvature (HP:0100692)1.70881742
126Abnormality of chromosome stability (HP:0003220)1.70332633
127Hypoplastic iliac wings (HP:0002866)1.69821797
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69471411
129Abnormality of alanine metabolism (HP:0010916)1.69471411
130Hyperalaninemia (HP:0003348)1.69471411
131Dyschromatopsia (HP:0007641)1.69365289
132Decreased circulating renin level (HP:0003351)1.69087400
133Thyroid-stimulating hormone excess (HP:0002925)1.69034629
134Choroideremia (HP:0001139)1.68764484
135Postural instability (HP:0002172)1.68240010
136Central scotoma (HP:0000603)1.68030801
137Congenital sensorineural hearing impairment (HP:0008527)1.67139475
138Anteriorly placed anus (HP:0001545)1.67083325
139Hypsarrhythmia (HP:0002521)1.66874194
140Specific learning disability (HP:0001328)1.65775894
141Chromsome breakage (HP:0040012)1.65346177
142Gait imbalance (HP:0002141)1.64249370
143Male pseudohermaphroditism (HP:0000037)1.64030647
144Abnormality of the fingertips (HP:0001211)1.64017891
145Deeply set eye (HP:0000490)1.64013491
146Bilateral microphthalmos (HP:0007633)1.63973750
147Tented upper lip vermilion (HP:0010804)1.63920660
148Impaired smooth pursuit (HP:0007772)1.63562373
149Enlarged kidneys (HP:0000105)1.63069592
150Cutaneous syndactyly (HP:0012725)1.62821693
151Absent eyebrow (HP:0002223)1.62701486
152Truncal obesity (HP:0001956)1.62085148
153Heterotopia (HP:0002282)1.61136529
154Lip pit (HP:0100267)1.60857066
155Dysdiadochokinesis (HP:0002075)1.60227657
156Hypoplasia of the brainstem (HP:0002365)1.59758440
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.59758440
158Generalized tonic-clonic seizures (HP:0002069)1.59596146
159Labial hypoplasia (HP:0000066)1.59581778
160Open mouth (HP:0000194)1.59230884
161Papillary thyroid carcinoma (HP:0002895)1.58943825
162Relative macrocephaly (HP:0004482)1.57847441
163Supranuclear gaze palsy (HP:0000605)1.57359091
164Agitation (HP:0000713)1.57048213
165Hepatoblastoma (HP:0002884)1.55336274
166Depression (HP:0000716)1.54706227
167Hypoplastic labia majora (HP:0000059)1.53726828
168Progressive sensorineural hearing impairment (HP:0000408)1.52910993
169Neuroendocrine neoplasm (HP:0100634)1.52896628
170Obsessive-compulsive behavior (HP:0000722)1.52888668
171Abnormality of ocular smooth pursuit (HP:0000617)1.51783223
172Bradycardia (HP:0001662)1.50529559
173Dysmetria (HP:0001310)1.49693371
174Hip dysplasia (HP:0001385)1.49324900
175Hypoplastic female external genitalia (HP:0012815)1.49168461
176Thyroid carcinoma (HP:0002890)1.48135866
177Decreased motor nerve conduction velocity (HP:0003431)1.47656761
178Ulnar claw (HP:0001178)1.47283886
179Visual hallucinations (HP:0002367)1.46721991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.61986406
2PRPF4B3.59537956
3CASK3.37822564
4AKT33.07668961
5SGK22.96316515
6MARK12.66528328
7ACVR1B2.64839588
8SGK4942.58585281
9SGK2232.58585281
10TNIK2.45534185
11MAP2K72.44054723
12EPHA32.43069930
13MAP3K42.34100951
14EPHA42.21575863
15SGK32.17308788
16ADRBK22.08906681
17MAPK131.99937007
18MAP4K21.76013315
19PINK11.68870949
20SIK31.64633142
21FGFR21.60111667
22OXSR11.60061913
23NTRK21.59868003
24NLK1.58877603
25WNK41.58128423
26MINK11.55916627
27STK391.55256098
28MKNK21.52637009
29CAMK1G1.47661345
30GRK11.47182626
31BRSK21.40594645
32BRD41.39486481
33TAOK31.38592232
34CAMK1D1.38369376
35YES11.31430561
36CDK121.26940638
37DYRK31.25130192
38WNK11.24777063
39NEK61.22936468
40TXK1.21798490
41TLK11.21296814
42STK38L1.16879671
43FGFR31.14000415
44PAK61.11361214
45FRK1.09882136
46SIK21.07211303
47TRIM281.06903381
48LATS11.05397222
49PRKCH1.05288308
50OBSCN1.03580879
51SGK11.02959296
52PLK21.01403072
53MAP3K121.00077911
54TGFBR10.98485491
55KSR10.98115390
56CDK50.97821998
57INSRR0.97076045
58MAP2K40.96679707
59DYRK1A0.95990152
60CAMKK20.95304867
61CSNK1G10.93832974
62MAP3K90.92565440
63BMPR1B0.91693976
64NTRK10.90983873
65PRKD30.86148464
66DAPK20.82502791
67STK30.81842439
68UHMK10.79954796
69PRKCE0.79692439
70RPS6KB10.79152259
71CSNK1G20.77905477
72RIPK40.75523694
73ERBB30.74395613
74PIK3CA0.73345516
75MKNK10.70892170
76PRKCG0.69601755
77CAMK40.68873979
78RET0.68349984
79TRPM70.67673034
80TIE10.65630340
81DYRK20.65330779
82FER0.64243064
83MAP3K20.63474737
84NEK20.63266891
85PRKAA20.62467461
86MAPK70.61499407
87TEC0.61153966
88CDK190.59747481
89CSNK1G30.59179451
90EIF2AK30.58566110
91CDC42BPA0.57877141
92PHKG10.56011627
93PHKG20.56011627
94PLK40.53428064
95CSNK1D0.53028556
96MARK20.52318323
97ERBB20.52208341
98CAMK2A0.52192575
99MAP3K70.51798552
100RPS6KA20.51703645
101STK380.51670364
102ATM0.50849569
103MAPK100.50366647
104MUSK0.50061819
105CDK30.49632824
106BCR0.49627961
107ATR0.49432844
108TAF10.48858631
109PNCK0.48428473
110NUAK10.47664231
111MARK30.45438207
112PKN10.45389148
113BMPR20.44916227
114FGFR10.44628365
115MAPKAPK30.44266075
116RPS6KA50.43006336
117GRK50.42987761
118MAPKAPK50.41490504
119TNK20.41379515
120STK110.41374094
121MAPK80.41336916
122ROCK10.40759216
123LMTK20.40272231
124PDK10.40059491
125PRKCZ0.39309364
126TYRO30.37581407
127ZAK0.37540156
128RPS6KA30.37496777
129GSK3B0.37433637
130ADRBK10.37418627
131PAK30.37207374
132ROCK20.36662172
133DDR20.36502705
134CSNK1A1L0.35438567
135IRAK10.34859308
136PIK3CG0.33688506
137CDC70.32977098
138LATS20.32672831
139PRKG10.32492716
140MAP3K130.31757968
141WNK30.31519988
142CAMK10.31445541
143JAK10.31125094
144PRKAA10.31080876
145FES0.30670365

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.55400413
2Phototransduction_Homo sapiens_hsa047442.54791278
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.31811380
4Selenocompound metabolism_Homo sapiens_hsa004502.31327867
5Linoleic acid metabolism_Homo sapiens_hsa005912.29243978
6Nitrogen metabolism_Homo sapiens_hsa009102.28144339
7Olfactory transduction_Homo sapiens_hsa047402.17762862
8Basal transcription factors_Homo sapiens_hsa030222.13781252
9Circadian entrainment_Homo sapiens_hsa047132.08078323
10Ether lipid metabolism_Homo sapiens_hsa005652.06574146
11Fanconi anemia pathway_Homo sapiens_hsa034602.03108440
12Synaptic vesicle cycle_Homo sapiens_hsa047212.00239470
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.93151744
14Morphine addiction_Homo sapiens_hsa050321.93066692
15Homologous recombination_Homo sapiens_hsa034401.90952865
16Long-term potentiation_Homo sapiens_hsa047201.89922679
17Glutamatergic synapse_Homo sapiens_hsa047241.89918393
18Butanoate metabolism_Homo sapiens_hsa006501.86268835
19Non-homologous end-joining_Homo sapiens_hsa034501.85057371
20GABAergic synapse_Homo sapiens_hsa047271.82953952
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82839817
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74257498
23Taste transduction_Homo sapiens_hsa047421.68014364
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60406128
25Cholinergic synapse_Homo sapiens_hsa047251.58827501
26Propanoate metabolism_Homo sapiens_hsa006401.58636217
27Insulin secretion_Homo sapiens_hsa049111.58537892
28Dopaminergic synapse_Homo sapiens_hsa047281.57294788
29Phosphatidylinositol signaling system_Homo sapiens_hsa040701.56536153
30Axon guidance_Homo sapiens_hsa043601.49634839
31ABC transporters_Homo sapiens_hsa020101.49354037
32Salivary secretion_Homo sapiens_hsa049701.48696712
33Tryptophan metabolism_Homo sapiens_hsa003801.48496465
34RNA degradation_Homo sapiens_hsa030181.46164771
35Serotonergic synapse_Homo sapiens_hsa047261.45781171
36Lysine degradation_Homo sapiens_hsa003101.43535959
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43176780
38Renin secretion_Homo sapiens_hsa049241.40951635
39Amphetamine addiction_Homo sapiens_hsa050311.40006532
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.39957999
41Maturity onset diabetes of the young_Homo sapiens_hsa049501.39522149
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31457058
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.30744309
44ErbB signaling pathway_Homo sapiens_hsa040121.30040334
45Type II diabetes mellitus_Homo sapiens_hsa049301.29935319
46Gastric acid secretion_Homo sapiens_hsa049711.29607342
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.29552803
48RNA polymerase_Homo sapiens_hsa030201.28702312
49Long-term depression_Homo sapiens_hsa047301.27831544
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21979913
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20840391
52Calcium signaling pathway_Homo sapiens_hsa040201.18002728
53Oxytocin signaling pathway_Homo sapiens_hsa049211.17664818
54Endometrial cancer_Homo sapiens_hsa052131.17481410
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.16464277
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12746863
57Glioma_Homo sapiens_hsa052141.10664267
58Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.10441067
59Gap junction_Homo sapiens_hsa045401.09862508
60cAMP signaling pathway_Homo sapiens_hsa040241.09507659
61GnRH signaling pathway_Homo sapiens_hsa049121.08794140
62Melanogenesis_Homo sapiens_hsa049161.07235754
63Dorso-ventral axis formation_Homo sapiens_hsa043201.07050007
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07011084
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.06557851
66Regulation of autophagy_Homo sapiens_hsa041401.06151500
67One carbon pool by folate_Homo sapiens_hsa006701.06032535
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02261840
69mTOR signaling pathway_Homo sapiens_hsa041501.01992882
70Wnt signaling pathway_Homo sapiens_hsa043101.01639523
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99682980
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97970007
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97501026
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.95249303
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95066124
76Inositol phosphate metabolism_Homo sapiens_hsa005620.94980483
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94151848
78Glycerolipid metabolism_Homo sapiens_hsa005610.94141592
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.93633332
80MAPK signaling pathway_Homo sapiens_hsa040100.92935639
81Cocaine addiction_Homo sapiens_hsa050300.91882103
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88121550
83Dilated cardiomyopathy_Homo sapiens_hsa054140.87920703
84TGF-beta signaling pathway_Homo sapiens_hsa043500.87790503
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87572896
86Circadian rhythm_Homo sapiens_hsa047100.86784294
87Caffeine metabolism_Homo sapiens_hsa002320.86229633
88Colorectal cancer_Homo sapiens_hsa052100.84485954
89Rap1 signaling pathway_Homo sapiens_hsa040150.82439244
90Estrogen signaling pathway_Homo sapiens_hsa049150.82264362
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82069536
92Ras signaling pathway_Homo sapiens_hsa040140.82051681
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80655812
94Basal cell carcinoma_Homo sapiens_hsa052170.80274968
95Choline metabolism in cancer_Homo sapiens_hsa052310.80190478
96Melanoma_Homo sapiens_hsa052180.79271334
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.78305194
98Non-small cell lung cancer_Homo sapiens_hsa052230.77690126
99Hedgehog signaling pathway_Homo sapiens_hsa043400.76627217
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75815062
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.74603928
102Oocyte meiosis_Homo sapiens_hsa041140.74441797
103Retinol metabolism_Homo sapiens_hsa008300.72087292
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.71920905
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71696300
106Alcoholism_Homo sapiens_hsa050340.69645834
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68528653
108beta-Alanine metabolism_Homo sapiens_hsa004100.67172788
109Adherens junction_Homo sapiens_hsa045200.66839206
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66372402
111Histidine metabolism_Homo sapiens_hsa003400.65781465
112Renal cell carcinoma_Homo sapiens_hsa052110.65253492
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65064429
114Peroxisome_Homo sapiens_hsa041460.64825102
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64406868
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64383641
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63815566
118Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62321249
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62293180
120Hippo signaling pathway_Homo sapiens_hsa043900.61866888
121FoxO signaling pathway_Homo sapiens_hsa040680.61402035
122Glucagon signaling pathway_Homo sapiens_hsa049220.61220200
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61057647
124Prostate cancer_Homo sapiens_hsa052150.60544198
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60319117
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.59297980
127Insulin signaling pathway_Homo sapiens_hsa049100.58040851
128Collecting duct acid secretion_Homo sapiens_hsa049660.56749960
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56511846
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56503234
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55729855
132Endocytosis_Homo sapiens_hsa041440.55311069
133Pancreatic cancer_Homo sapiens_hsa052120.54768162
134Ovarian steroidogenesis_Homo sapiens_hsa049130.54258445
135Thyroid hormone synthesis_Homo sapiens_hsa049180.54218533
136Prolactin signaling pathway_Homo sapiens_hsa049170.53931702
137Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53729214
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51116550
139Proteoglycans in cancer_Homo sapiens_hsa052050.50723697
140Pancreatic secretion_Homo sapiens_hsa049720.50563503
141Chemical carcinogenesis_Homo sapiens_hsa052040.48815977
142p53 signaling pathway_Homo sapiens_hsa041150.47261520
143Arachidonic acid metabolism_Homo sapiens_hsa005900.46747897
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.43598475
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43255540
146Purine metabolism_Homo sapiens_hsa002300.42357800
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37456737
148Vitamin digestion and absorption_Homo sapiens_hsa049770.37275873
149mRNA surveillance pathway_Homo sapiens_hsa030150.35340280
150RNA transport_Homo sapiens_hsa030130.33375932
151Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33353730
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.32650878
153Protein export_Homo sapiens_hsa030600.32418455

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