LRFN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)5.04897925
2protein retention in ER lumen (GO:0006621)4.40490853
3regulation of mammary gland epithelial cell proliferation (GO:0033599)4.36100047
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.07486649
5cell migration in hindbrain (GO:0021535)4.03005142
6activation of Rac GTPase activity (GO:0032863)4.01465816
7GDP-mannose metabolic process (GO:0019673)4.00357601
8locomotory exploration behavior (GO:0035641)3.94040555
9proline biosynthetic process (GO:0006561)3.92796923
10basement membrane organization (GO:0071711)3.89893236
11regulation of translational fidelity (GO:0006450)3.86610238
12focal adhesion assembly (GO:0048041)3.84495071
13dendritic spine morphogenesis (GO:0060997)3.80366351
14UV protection (GO:0009650)3.79753331
15apoptotic process involved in morphogenesis (GO:0060561)3.79522181
16regulation of early endosome to late endosome transport (GO:2000641)3.77295698
17synaptic vesicle maturation (GO:0016188)3.75972930
18Golgi transport vesicle coating (GO:0048200)3.67525018
19COPI coating of Golgi vesicle (GO:0048205)3.67525018
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65211379
21regulation of NFAT protein import into nucleus (GO:0051532)3.63255503
22cytoskeletal anchoring at plasma membrane (GO:0007016)3.60420849
23positive regulation of synapse maturation (GO:0090129)3.56192945
24cerebellar Purkinje cell layer development (GO:0021680)3.46821364
25planar cell polarity pathway involved in neural tube closure (GO:0090179)3.44649388
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.42278826
27cell-substrate junction assembly (GO:0007044)3.39975760
28polarized epithelial cell differentiation (GO:0030859)3.38590849
29negative regulation of catenin import into nucleus (GO:0035414)3.36963236
30negative regulation of erythrocyte differentiation (GO:0045647)3.33534004
31regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.33200587
32epithelial cell-cell adhesion (GO:0090136)3.29835281
33axonal fasciculation (GO:0007413)3.27264238
34atrioventricular valve morphogenesis (GO:0003181)3.23621487
35protein localization to endosome (GO:0036010)3.21042841
36synaptic vesicle docking involved in exocytosis (GO:0016081)3.19841715
37vocalization behavior (GO:0071625)3.17901187
38maternal placenta development (GO:0001893)3.15923061
39DNA unwinding involved in DNA replication (GO:0006268)3.15582042
40dendrite morphogenesis (GO:0048813)3.14633827
41adenine nucleotide transport (GO:0051503)3.14075075
42hemidesmosome assembly (GO:0031581)3.11862717
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.10904769
44plasma membrane repair (GO:0001778)3.10479247
45pyrimidine nucleobase catabolic process (GO:0006208)3.09604300
46endothelial cell chemotaxis (GO:0035767)3.08643015
47regulation of glucose import in response to insulin stimulus (GO:2001273)3.08089273
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.07267995
49mannose metabolic process (GO:0006013)3.07208464
50convergent extension (GO:0060026)3.06770129
51regulation of hippo signaling (GO:0035330)3.06159491
52establishment of nucleus localization (GO:0040023)3.05060964
53exploration behavior (GO:0035640)3.04253357
54G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.04119931
55negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.01414392
56cell communication by electrical coupling (GO:0010644)2.99283911
57central nervous system projection neuron axonogenesis (GO:0021952)2.94889371
58axon extension (GO:0048675)2.93927630
59dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.92902988
60neuron recognition (GO:0008038)2.89826530
61negative regulation of fatty acid transport (GO:2000192)2.89296887
62negative regulation of microtubule polymerization (GO:0031115)2.86901045
63regulation of synapse structural plasticity (GO:0051823)2.86813559
64negative regulation of glycogen biosynthetic process (GO:0045719)2.86807543
65desmosome organization (GO:0002934)2.86270446
66hippo signaling (GO:0035329)2.85782147
67activation of protein kinase A activity (GO:0034199)2.85127485
68protein complex localization (GO:0031503)2.84445403
69adenosine receptor signaling pathway (GO:0001973)2.83808487
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.83731131
71peptidyl-arginine omega-N-methylation (GO:0035247)2.83121780
72negative regulation of cell size (GO:0045792)2.82832991
73proline transport (GO:0015824)2.82338630
74actin filament bundle assembly (GO:0051017)2.81800493
75actin filament bundle organization (GO:0061572)2.81800493
76gastrulation with mouth forming second (GO:0001702)2.81646952
77glutamate secretion (GO:0014047)2.81075635
78sodium ion export (GO:0071436)2.81018278
79glial cell proliferation (GO:0014009)2.80751424
80cellular protein complex localization (GO:0034629)2.79982000
81glucose catabolic process (GO:0006007)2.78967924
82regulation of glutamate receptor signaling pathway (GO:1900449)2.78820250
83pentose-phosphate shunt (GO:0006098)2.78391751
84regulation of chromatin binding (GO:0035561)2.78307102
85insulin-like growth factor receptor signaling pathway (GO:0048009)2.76328287
86positive regulation of dendrite morphogenesis (GO:0050775)2.75710045
87neuromuscular process controlling balance (GO:0050885)2.75650982
88dendritic spine organization (GO:0097061)2.75578379
89axon extension involved in axon guidance (GO:0048846)2.75244656
90neuron projection extension involved in neuron projection guidance (GO:1902284)2.75244656
91peptidyl-lysine dimethylation (GO:0018027)2.73098964
92mitotic chromosome condensation (GO:0007076)2.73000561
93adherens junction assembly (GO:0034333)2.72443745
94nuclear envelope reassembly (GO:0031468)2.71327308
95mitotic nuclear envelope reassembly (GO:0007084)2.71327308
96establishment or maintenance of monopolar cell polarity (GO:0061339)2.69392234
97establishment of monopolar cell polarity (GO:0061162)2.69392234
98barbed-end actin filament capping (GO:0051016)2.69282810
99establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.68506331
100positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.68089773
101positive regulation of axon extension (GO:0045773)2.67963279
102collecting duct development (GO:0072044)2.67346214
103protein heterotrimerization (GO:0070208)2.66822718
104modulation by virus of host process (GO:0019054)2.66502783
105peptidyl-arginine methylation (GO:0018216)2.65426796
106peptidyl-arginine N-methylation (GO:0035246)2.65426796
107vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.64880665
108regulation of cholesterol biosynthetic process (GO:0045540)2.63084667
109protein localization to synapse (GO:0035418)2.62435965
110semaphorin-plexin signaling pathway (GO:0071526)2.62166104
111neuron projection extension (GO:1990138)2.60854432
112paraxial mesoderm development (GO:0048339)2.60783214
113establishment of apical/basal cell polarity (GO:0035089)2.59531022
114modulation by symbiont of host cellular process (GO:0044068)2.59366331
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.58897077
116embryonic foregut morphogenesis (GO:0048617)2.58678680
117pre-miRNA processing (GO:0031054)2.58513375
118spliceosomal tri-snRNP complex assembly (GO:0000244)2.58335223
119positive regulation of odontogenesis (GO:0042482)2.58144807
120positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.56870831
121proline metabolic process (GO:0006560)2.54185310
122mitochondrion transport along microtubule (GO:0047497)2.53639169
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.53639169
124intracellular estrogen receptor signaling pathway (GO:0030520)2.53404140
125snRNA metabolic process (GO:0016073)2.53021448
126nucleosome disassembly (GO:0006337)2.51902529
127protein-DNA complex disassembly (GO:0032986)2.51902529
128diaphragm development (GO:0060539)2.51751784
129ribosomal small subunit biogenesis (GO:0042274)2.51456699
130heterochromatin organization (GO:0070828)2.50200294
131endocytic recycling (GO:0032456)2.46974518
132folic acid metabolic process (GO:0046655)2.46675503
133protein insertion into membrane (GO:0051205)2.46201536
134regulation of apoptotic process involved in morphogenesis (GO:1902337)2.45840399
135postsynaptic membrane organization (GO:0001941)2.45799667
136synaptic vesicle exocytosis (GO:0016079)2.45579525
137regulation of fatty acid beta-oxidation (GO:0031998)2.45249960
138histone arginine methylation (GO:0034969)2.44677870
139protein targeting to plasma membrane (GO:0072661)2.44035629
140branching involved in salivary gland morphogenesis (GO:0060445)2.43852029
141inner ear receptor cell development (GO:0060119)2.43619100
142regulation of synaptic vesicle exocytosis (GO:2000300)2.42315951
143clathrin coat assembly (GO:0048268)2.42119587
144regulation of long-term neuronal synaptic plasticity (GO:0048169)2.41301443
145establishment of tissue polarity (GO:0007164)2.41163493
146establishment of planar polarity (GO:0001736)2.41163493
147regulation of axon extension involved in axon guidance (GO:0048841)2.41139558
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40311393
149outer ear morphogenesis (GO:0042473)2.39719586
150apoptotic process involved in development (GO:1902742)2.39563883
151glucocorticoid receptor signaling pathway (GO:0042921)2.38849278
152proximal/distal pattern formation (GO:0009954)2.38822699
153cerebellum development (GO:0021549)2.38422794
154nucleobase catabolic process (GO:0046113)2.38102337
155modulation by virus of host morphology or physiology (GO:0019048)2.37812493
156endothelial cell morphogenesis (GO:0001886)2.37705406
157negative regulation of glycogen metabolic process (GO:0070874)2.37524102
158purine nucleotide transport (GO:0015865)2.37289980
159activation of MAPKKK activity (GO:0000185)2.37152028
160cell-cell junction maintenance (GO:0045217)2.36454270
161ephrin receptor signaling pathway (GO:0048013)2.35633573
162purine ribonucleotide transport (GO:0015868)2.35353115
163embryonic eye morphogenesis (GO:0048048)2.34398754
164skeletal muscle organ development (GO:0060538)2.34227875
165branching involved in mammary gland duct morphogenesis (GO:0060444)2.33946728
166regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.33598302
167positive regulation of protein dephosphorylation (GO:0035307)2.33034145
168positive regulation of nuclease activity (GO:0032075)2.32574623
169regulation of neuronal synaptic plasticity (GO:0048168)2.31675106
170positive regulation of dendritic spine morphogenesis (GO:0061003)2.31446167
171body morphogenesis (GO:0010171)2.31222534
172neuron cell-cell adhesion (GO:0007158)2.31184744
173positive regulation of dendrite development (GO:1900006)2.29297870
174Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.27980442
175cell communication involved in cardiac conduction (GO:0086065)2.26550636
176adherens junction organization (GO:0034332)2.26225876
177regulation of establishment of planar polarity (GO:0090175)2.26084169
178stress fiber assembly (GO:0043149)2.25425937
179innervation (GO:0060384)2.24872013
180regulation of neuron migration (GO:2001222)2.24703833
181cell-substrate adherens junction assembly (GO:0007045)2.23836233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.16266287
2EZH2_22144423_ChIP-Seq_EOC_Human3.07796038
3VDR_21846776_ChIP-Seq_THP-1_Human3.06998748
4ZFP281_18757296_ChIP-ChIP_E14_Mouse3.02202060
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78894954
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.77158318
7* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.53605810
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.45283436
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36145174
10ZFP281_27345836_Chip-Seq_ESCs_Mouse2.32798297
11KDM2B_26808549_Chip-Seq_K562_Human2.23345229
12E2F7_22180533_ChIP-Seq_HELA_Human2.21068847
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.15476785
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.15476785
15TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.15376509
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07009786
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06335339
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.05472419
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.04023800
20DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.03239940
21ZNF263_19887448_ChIP-Seq_K562_Human2.02854791
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.02681762
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.00608900
24* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.98882729
25DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.97153340
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95654593
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95491937
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95036326
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.90302381
30P68_20966046_ChIP-Seq_HELA_Human1.89351492
31SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89002208
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.88868934
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.84883523
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.84167190
35* KDM2B_26808549_Chip-Seq_DND41_Human1.81814500
36DROSHA_22980978_ChIP-Seq_HELA_Human1.81615492
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81466239
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78368083
39* LXR_22292898_ChIP-Seq_THP-1_Human1.78148442
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.76917210
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76599119
42* TET1_21451524_ChIP-Seq_MESCs_Mouse1.76036895
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.72071879
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71748967
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.69869506
46RING1B_27294783_Chip-Seq_NPCs_Mouse1.67510860
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67259199
48SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67097394
49TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65561460
50SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64882739
51SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.63040271
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62791585
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.61758265
54HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.58854326
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58447620
56* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.57144234
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.57087962
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.56427657
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56117482
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55282916
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54095855
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.54070297
63XRN2_22483619_ChIP-Seq_HELA_Human1.53909629
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52881748
65* SMC4_20622854_ChIP-Seq_HELA_Human1.52818837
66* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52286628
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.51432316
68OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.49919255
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46719023
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46327585
71* CREB1_26743006_Chip-Seq_LNCaP_Human1.44814889
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.44748775
73* MYC_22102868_ChIP-Seq_BL_Human1.43316872
74ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42411212
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.42054141
76* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40663147
77RARG_19884340_ChIP-ChIP_MEFs_Mouse1.39385148
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37256121
79VDR_24763502_ChIP-Seq_THP-1_Human1.36334147
80TRIM28_21343339_ChIP-Seq_HEK293_Human1.35054333
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.35019189
82* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34117687
83* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32580312
84REST_21632747_ChIP-Seq_MESCs_Mouse1.32135986
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30530414
86* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.30513761
87CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30015801
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.29930042
89* RACK7_27058665_Chip-Seq_MCF-7_Human1.28948080
90MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28119582
91REST_18959480_ChIP-ChIP_MESCs_Mouse1.27817755
92CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27167978
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26190125
94ELF1_20517297_ChIP-Seq_JURKAT_Human1.25944422
95EGR1_19374776_ChIP-ChIP_THP-1_Human1.25298400
96MYC_18358816_ChIP-ChIP_MESCs_Mouse1.24401110
97* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24116211
98ZNF274_21170338_ChIP-Seq_K562_Hela1.23292388
99* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20518257
100MAF_26560356_Chip-Seq_TH2_Human1.19787664
101* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19684015
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19505946
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18878288
104* NCOR1_26117541_ChIP-Seq_K562_Human1.17924716
105BCOR_27268052_Chip-Seq_Bcells_Human1.16596064
106FOXM1_23109430_ChIP-Seq_U2OS_Human1.16408471
107MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15521445
108TCF7_22412390_ChIP-Seq_EML_Mouse1.15141659
109SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14424668
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13231529
111UBF1/2_26484160_Chip-Seq_HMECs_Human1.13174649
112CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13101821
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11982465
114CTCF_27219007_Chip-Seq_Bcells_Human1.11779354
115TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09803737
116RARA_24833708_ChIP-Seq_LIVER_Mouse1.09751988
117* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08873922
118* MAF_26560356_Chip-Seq_TH1_Human1.08397872
119* TP53_22127205_ChIP-Seq_IMR90_Human1.08319809
120CLOCK_20551151_ChIP-Seq_293T_Human1.08073973
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07842632
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07734108
123FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.07114756
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06781576
125FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06691218
126FOXP1_21924763_ChIP-Seq_HESCs_Human1.06427899
127ATF3_27146783_Chip-Seq_COLON_Human1.06152774
128RARB_24833708_ChIP-Seq_LIVER_Mouse1.05849853
129STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05642602
130TP53_23651856_ChIP-Seq_MEFs_Mouse1.04659977
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04317138
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03853328
133CTCF_21964334_Chip-Seq_Bcells_Human1.03847761
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02599899
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02200834
136* BCL6_27268052_Chip-Seq_Bcells_Human1.02075882
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02066187
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01710160
139NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00905211
140ESR2_21235772_ChIP-Seq_MCF-7_Human1.00618935
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00453840
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00400740
143PHF8_20622854_ChIP-Seq_HELA_Human1.00134598
144THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99469636
145* TET1_21490601_ChIP-Seq_MESCs_Mouse0.98973832
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98875355
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98261617
148CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97775060
149SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96655871
150MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96268658
151IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95377728
152RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95200423
153NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94212667
154RUNX1_27514584_Chip-Seq_MCF-7_Human0.93724533
155SOX3_22085726_ChIP-Seq_NPCs_Mouse0.92606327

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.78019423
2MP0003283_abnormal_digestive_organ2.89823013
3MP0003705_abnormal_hypodermis_morpholog2.78813994
4MP0010030_abnormal_orbit_morphology2.75442852
5MP0000537_abnormal_urethra_morphology2.70554411
6MP0005058_abnormal_lysosome_morphology2.65354144
7MP0005409_darkened_coat_color2.63449678
8MP0005451_abnormal_body_composition2.58590713
9MP0004185_abnormal_adipocyte_glucose2.57999779
10MP0003122_maternal_imprinting2.56301755
11MP0002653_abnormal_ependyma_morphology2.39265287
12MP0003453_abnormal_keratinocyte_physiol2.38432610
13MP0005623_abnormal_meninges_morphology2.33858453
14MP0009780_abnormal_chondrocyte_physiolo2.27185606
15MP0004858_abnormal_nervous_system2.25144637
16MP0005171_absent_coat_pigmentation2.07280657
17MP0004270_analgesia2.06347420
18MP0003123_paternal_imprinting1.99167101
19MP0000778_abnormal_nervous_system1.98673154
20MP0005076_abnormal_cell_differentiation1.96917291
21MP0003635_abnormal_synaptic_transmissio1.96453949
22MP0003119_abnormal_digestive_system1.91316567
23MP0003111_abnormal_nucleus_morphology1.86418128
24MP0005501_abnormal_skin_physiology1.82114539
25MP0009278_abnormal_bone_marrow1.80467722
26MP0002234_abnormal_pharynx_morphology1.79841594
27MP0008438_abnormal_cutaneous_collagen1.77959553
28MP0004233_abnormal_muscle_weight1.73311034
29MP0003385_abnormal_body_wall1.71199515
30MP0005187_abnormal_penis_morphology1.67371311
31MP0001849_ear_inflammation1.65592773
32MP0002796_impaired_skin_barrier1.63711140
33MP0001348_abnormal_lacrimal_gland1.63700443
34MP0000534_abnormal_ureter_morphology1.62975740
35MP0008961_abnormal_basal_metabolism1.62754491
36MP0002063_abnormal_learning/memory/cond1.61104143
37MP0010234_abnormal_vibrissa_follicle1.59919212
38MP0002089_abnormal_postnatal_growth/wei1.59484428
39MP0009053_abnormal_anal_canal1.53313658
40MP0003942_abnormal_urinary_system1.53132954
41MP0005375_adipose_tissue_phenotype1.52946819
42MP0005666_abnormal_adipose_tissue1.52319268
43MP0000428_abnormal_craniofacial_morphol1.46087656
44MP0002060_abnormal_skin_morphology1.43611588
45MP0002909_abnormal_adrenal_gland1.42964157
46MP0003115_abnormal_respiratory_system1.42932482
47MP0003121_genomic_imprinting1.40923232
48MP0001299_abnormal_eye_distance/1.40112630
49MP0009840_abnormal_foam_cell1.39007267
50MP0003861_abnormal_nervous_system1.37213722
51MP0004811_abnormal_neuron_physiology1.36294013
52MP0000955_abnormal_spinal_cord1.35116045
53MP0002184_abnormal_innervation1.32798212
54MP0000579_abnormal_nail_morphology1.31526650
55MP0003279_aneurysm1.29852315
56MP0004272_abnormal_basement_membrane1.28955412
57MP0000747_muscle_weakness1.27047141
58MP0003693_abnormal_embryo_hatching1.26138451
59MP0002896_abnormal_bone_mineralization1.23544104
60MP0010352_gastrointestinal_tract_polyps1.23249700
61MP0001188_hyperpigmentation1.22837856
62MP0000678_abnormal_parathyroid_gland1.22826280
63MP0000750_abnormal_muscle_regeneration1.20026521
64MP0000751_myopathy1.19996325
65MP0000049_abnormal_middle_ear1.16406128
66MP0008260_abnormal_autophagy1.16383321
67MP0002152_abnormal_brain_morphology1.13997568
68MP0003755_abnormal_palate_morphology1.13980936
69MP0002116_abnormal_craniofacial_bone1.13807309
70MP0003329_amyloid_beta_deposits1.12064131
71MP0004197_abnormal_fetal_growth/weight/1.11667109
72MP0000467_abnormal_esophagus_morphology1.10952672
73MP0003935_abnormal_craniofacial_develop1.10617074
74MP0004957_abnormal_blastocyst_morpholog1.10556678
75MP0003172_abnormal_lysosome_physiology1.10436876
76MP0000569_abnormal_digit_pigmentation1.10433839
77MP0002254_reproductive_system_inflammat1.10385652
78MP0005083_abnormal_biliary_tract1.07649924
79MP0000733_abnormal_muscle_development1.07532948
80MP0003077_abnormal_cell_cycle1.07498936
81MP0000003_abnormal_adipose_tissue1.07155333
82MP0005503_abnormal_tendon_morphology1.06866366
83MP0005275_abnormal_skin_tensile1.06654449
84MP0000013_abnormal_adipose_tissue1.05965245
85MP0002734_abnormal_mechanical_nocicepti1.05354531
86MP0002877_abnormal_melanocyte_morpholog1.05160945
87MP0002233_abnormal_nose_morphology1.03591013
88MP0005248_abnormal_Harderian_gland1.02287426
89MP0000350_abnormal_cell_proliferation1.02175679
90MP0002084_abnormal_developmental_patter1.00986774
91MP0009745_abnormal_behavioral_response1.00340710
92MP0002572_abnormal_emotion/affect_behav1.00133486
93MP0002080_prenatal_lethality0.99958452
94MP0005621_abnormal_cell_physiology0.98760508
95MP0000759_abnormal_skeletal_muscle0.98633465
96MP0000462_abnormal_digestive_system0.98004172
97MP0005394_taste/olfaction_phenotype0.97521197
98MP0005499_abnormal_olfactory_system0.97521197
99MP0002085_abnormal_embryonic_tissue0.96800687
100MP0002932_abnormal_joint_morphology0.96677477
101MP0010771_integument_phenotype0.96218261
102MP0009250_abnormal_appendicular_skeleto0.95782393
103MP0002249_abnormal_larynx_morphology0.95573114
104MP0000858_altered_metastatic_potential0.95510655
105MP0002733_abnormal_thermal_nociception0.95390937
106MP0009384_cardiac_valve_regurgitation0.95139140
107MP0002081_perinatal_lethality0.95119154
108MP0003634_abnormal_glial_cell0.92226345
109MP0004133_heterotaxia0.91950404
110MP0002882_abnormal_neuron_morphology0.91744292
111MP0005423_abnormal_somatic_nervous0.91126120
112MP0004808_abnormal_hematopoietic_stem0.91123513
113MP0002557_abnormal_social/conspecific_i0.90991155
114MP0009931_abnormal_skin_appearance0.90528534
115MP0002111_abnormal_tail_morphology0.89845411
116MP0001216_abnormal_epidermal_layer0.88946986
117MP0001661_extended_life_span0.88826960
118MP0000767_abnormal_smooth_muscle0.88727751
119MP0000631_abnormal_neuroendocrine_gland0.88119214
120MP0008789_abnormal_olfactory_epithelium0.87901766
121MP0003136_yellow_coat_color0.87721515
122MP0003566_abnormal_cell_adhesion0.86866817
123MP0009672_abnormal_birth_weight0.86307874
124MP0005023_abnormal_wound_healing0.83043178
125MP0004087_abnormal_muscle_fiber0.82998256
126MP0002064_seizures0.82795239
127MP0002086_abnormal_extraembryonic_tissu0.82371176
128MP0005174_abnormal_tail_pigmentation0.82307623
129MP0002282_abnormal_trachea_morphology0.82060466
130MP0000538_abnormal_urinary_bladder0.81699794
131MP0008932_abnormal_embryonic_tissue0.81381697
132MP0000762_abnormal_tongue_morphology0.80477430
133MP0008770_decreased_survivor_rate0.79916795
134MP0005508_abnormal_skeleton_morphology0.78582929
135MP0004885_abnormal_endolymph0.78211343
136MP0001672_abnormal_embryogenesis/_devel0.77964787
137MP0005380_embryogenesis_phenotype0.77964787
138MP0003937_abnormal_limbs/digits/tail_de0.77761692
139MP0003984_embryonic_growth_retardation0.77476963
140MP0002098_abnormal_vibrissa_morphology0.77017854
141MP0005670_abnormal_white_adipose0.76757778
142MP0005257_abnormal_intraocular_pressure0.76491906
143MP0004381_abnormal_hair_follicle0.76414709
144MP0003137_abnormal_impulse_conducting0.76232782
145MP0001346_abnormal_lacrimal_gland0.75430858
146MP0009703_decreased_birth_body0.74300411
147MP0003890_abnormal_embryonic-extraembry0.74073557
148MP0003787_abnormal_imprinting0.73895753
149MP0002697_abnormal_eye_size0.73173591
150MP0000432_abnormal_head_morphology0.72973727
151MP0010630_abnormal_cardiac_muscle0.72711990
152MP0001440_abnormal_grooming_behavior0.72319254
153MP0010307_abnormal_tumor_latency0.71760678
154MP0001968_abnormal_touch/_nociception0.71741014
155MP0005384_cellular_phenotype0.71591402
156MP0001730_embryonic_growth_arrest0.71534767
157MP0002114_abnormal_axial_skeleton0.71188607
158MP0001958_emphysema0.70343990
159MP0003091_abnormal_cell_migration0.70334209

Predicted human phenotypes

RankGene SetZ-score
1Ulnar bowing (HP:0003031)4.56443459
2Shallow orbits (HP:0000586)3.90680782
3Thin bony cortex (HP:0002753)3.49001713
4Protrusio acetabuli (HP:0003179)3.36968181
5Hyperacusis (HP:0010780)3.27947035
6Renal duplication (HP:0000075)3.20538817
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.09121788
8Short 4th metacarpal (HP:0010044)3.09121788
9Broad face (HP:0000283)3.08557026
10Distal lower limb amyotrophy (HP:0008944)2.94738763
11Insomnia (HP:0100785)2.88073206
12Testicular atrophy (HP:0000029)2.76472899
13Elfin facies (HP:0004428)2.71071412
14Bladder diverticulum (HP:0000015)2.69628290
15Bowel diverticulosis (HP:0005222)2.65153815
16Premature rupture of membranes (HP:0001788)2.62657519
17Renovascular hypertension (HP:0100817)2.62264207
18Overriding aorta (HP:0002623)2.57001359
19Cerebral aneurysm (HP:0004944)2.54339356
20Bowed forearm bones (HP:0003956)2.51901739
21Bowing of the arm (HP:0006488)2.51901739
22Annular pancreas (HP:0001734)2.51269187
23Pointed chin (HP:0000307)2.49805087
24Vertebral compression fractures (HP:0002953)2.47098551
25Cervical subluxation (HP:0003308)2.46588517
26Abnormality of the 4th metacarpal (HP:0010012)2.45531364
27Thin ribs (HP:0000883)2.39409401
28Genu recurvatum (HP:0002816)2.37593725
29Ankle contracture (HP:0006466)2.35279405
30Elbow flexion contracture (HP:0002987)2.31454323
31Distal lower limb muscle weakness (HP:0009053)2.28436398
32Long palpebral fissure (HP:0000637)2.26869464
33Abnormality of the astrocytes (HP:0100707)2.26786421
34Astrocytoma (HP:0009592)2.26786421
35Stridor (HP:0010307)2.26658976
36Ankyloglossia (HP:0010296)2.25183298
37Broad metatarsal (HP:0001783)2.24365710
38Flat cornea (HP:0007720)2.23243891
39Joint stiffness (HP:0001387)2.23197249
40Abnormality of the lower motor neuron (HP:0002366)2.22237962
41Bronchomalacia (HP:0002780)2.20767773
42Biconcave vertebral bodies (HP:0004586)2.20739240
43Disproportionate tall stature (HP:0001519)2.20212671
44Increased connective tissue (HP:0009025)2.19482552
45Generalized amyotrophy (HP:0003700)2.18459341
46Deviation of the hallux (HP:0010051)2.16580387
47Atrophic scars (HP:0001075)2.16313305
48Myokymia (HP:0002411)2.14801805
49Hallux valgus (HP:0001822)2.12947056
50Insidious onset (HP:0003587)2.12856852
51Termporal pattern (HP:0011008)2.12856852
52Spinal rigidity (HP:0003306)2.12565866
53Mitral regurgitation (HP:0001653)2.12470534
54Upper limb amyotrophy (HP:0009129)2.12087316
55Distal upper limb amyotrophy (HP:0007149)2.12087316
56Trismus (HP:0000211)2.10537364
57Neoplasm of the heart (HP:0100544)2.09467577
58Facial hemangioma (HP:0000329)2.09431848
59Hepatoblastoma (HP:0002884)2.09431607
60Buphthalmos (HP:0000557)2.08627996
61Enlarged penis (HP:0000040)2.06670089
62Short nail (HP:0001799)2.04786752
63Visual hallucinations (HP:0002367)2.03792722
64Turricephaly (HP:0000262)2.02162660
65Myopathic facies (HP:0002058)2.00062767
66Progressive muscle weakness (HP:0003323)1.98897474
67Megalencephaly (HP:0001355)1.98805350
68Hypoventilation (HP:0002791)1.97937363
69Patellar dislocation (HP:0002999)1.96480173
70Lymphangioma (HP:0100764)1.95860751
71Macroorchidism (HP:0000053)1.95641453
72Flat acetabular roof (HP:0003180)1.94449319
73Poikiloderma (HP:0001029)1.93890393
74Abnormality of the thoracic spine (HP:0100711)1.93515224
75Hand muscle atrophy (HP:0009130)1.93297319
76Asymmetry of the thorax (HP:0001555)1.93055231
77Abnormality of the distal phalanges of the toes (HP:0010182)1.91656320
78Pterygium (HP:0001059)1.91647127
79Broad distal phalanx of finger (HP:0009836)1.91235561
80Blue sclerae (HP:0000592)1.89362328
81Intestinal fistula (HP:0100819)1.89118971
82Amyotrophic lateral sclerosis (HP:0007354)1.88475705
83Increased nuchal translucency (HP:0010880)1.88040556
84Vaginal fistula (HP:0004320)1.87841569
85Abnormality of oral frenula (HP:0000190)1.87828456
86Fibroma (HP:0010614)1.87798549
87Abnormality of the diencephalon (HP:0010662)1.86352663
88Overgrowth (HP:0001548)1.86051324
89Premature skin wrinkling (HP:0100678)1.84221479
90Fragile skin (HP:0001030)1.84067531
91Easy fatigability (HP:0003388)1.83850236
92Lower limb amyotrophy (HP:0007210)1.83730385
93Flattened epiphyses (HP:0003071)1.83520202
94Wormian bones (HP:0002645)1.82663611
95Spinal cord compression (HP:0002176)1.81319278
96Slender long bone (HP:0003100)1.80809618
97Hypercortisolism (HP:0001578)1.80064037
98Coronal craniosynostosis (HP:0004440)1.79504430
99Bulbar palsy (HP:0001283)1.79364130
100Hyperparathyroidism (HP:0000843)1.79227399
101Congenital hip dislocation (HP:0001374)1.78968244
102Fibrous tissue neoplasm (HP:0012316)1.78637690
103Abnormality of the aortic arch (HP:0012303)1.78307595
104J-shaped sella turcica (HP:0002680)1.77871235
105Dilatation of the ascending aorta (HP:0005111)1.77845515
106Obstructive sleep apnea (HP:0002870)1.77836271
107Long toe (HP:0010511)1.77545750
108Rib fusion (HP:0000902)1.76970526
109Ependymoma (HP:0002888)1.76480336
110Trigonocephaly (HP:0000243)1.76243781
111Sacral dimple (HP:0000960)1.76214059
112Hemorrhage of the eye (HP:0011885)1.75874053
113Choanal stenosis (HP:0000452)1.75392131
114Achilles tendon contracture (HP:0001771)1.74281940
115Mildly elevated creatine phosphokinase (HP:0008180)1.74159910
116Megalocornea (HP:0000485)1.74101679
117Flared metaphyses (HP:0003015)1.74062135
118Congenital glaucoma (HP:0001087)1.73341431
119Abnormality of the distal phalanx of the thumb (HP:0009617)1.73218733
120Papilledema (HP:0001085)1.71697063
121Arnold-Chiari malformation (HP:0002308)1.71317443
122Deviation of the thumb (HP:0009603)1.69439631
123Subacute progressive viral hepatitis (HP:0006572)1.69247856
124Mitral valve prolapse (HP:0001634)1.68029110
125Focal seizures (HP:0007359)1.66835403
126Glioma (HP:0009733)1.66516448
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.66385787
128Abnormality of the umbilical cord (HP:0010881)1.65408819
129Hyperextensible skin (HP:0000974)1.64602100
130Cerebral inclusion bodies (HP:0100314)1.64451510
131Breast hypoplasia (HP:0003187)1.64309506
132Increased variability in muscle fiber diameter (HP:0003557)1.64247502
133Natal tooth (HP:0000695)1.64033299
134Germ cell neoplasia (HP:0100728)1.63215269
135Nuclear cataract (HP:0100018)1.63068638
136Ragged-red muscle fibers (HP:0003200)1.62461418
137Wrist flexion contracture (HP:0001239)1.62420114
138Squamous cell carcinoma (HP:0002860)1.61045899
139Axonal loss (HP:0003447)1.60104822
140Advanced eruption of teeth (HP:0006288)1.59958014
141Neonatal short-limb short stature (HP:0008921)1.59932672
142Akinesia (HP:0002304)1.59890252
143Adducted thumb (HP:0001181)1.59665388
144Proximal placement of thumb (HP:0009623)1.59077080
145Spinal cord lesions (HP:0100561)1.58151924
146Syringomyelia (HP:0003396)1.58151924
147Apathy (HP:0000741)1.56482625
148Neoplasm of the adrenal cortex (HP:0100641)1.55457113
149Supranuclear gaze palsy (HP:0000605)1.55223332
150Shoulder girdle muscle weakness (HP:0003547)1.55158296
151Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.54729007
152Broad thumb (HP:0011304)1.54629928
153Hypercalcemia (HP:0003072)1.52939447
154Radial bowing (HP:0002986)1.52234299
155Difficulty climbing stairs (HP:0003551)1.50733104
156Precocious puberty (HP:0000826)1.48670829
157Pseudobulbar signs (HP:0002200)1.48547899
158Selective tooth agenesis (HP:0001592)1.48331746
159Ankle clonus (HP:0011448)1.47492638
160Morphological abnormality of the middle ear (HP:0008609)1.46635286
161Genetic anticipation (HP:0003743)1.46509706
162Hypoplastic toenails (HP:0001800)1.45781545
163Aqueductal stenosis (HP:0002410)1.45524544
164Intellectual disability, profound (HP:0002187)1.45021613
165Abnormality of the Achilles tendon (HP:0005109)1.44812116
166Torticollis (HP:0000473)1.44235522
167Aplasia of the phalanges of the hand (HP:0009802)1.42455061

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK4.03736118
2MARK13.71032665
3TRIB33.61306211
4PKN23.41637223
5SMG13.25939389
6IRAK33.21688112
7NME22.94316225
8CAMKK12.85810500
9LATS22.82717218
10MAP3K92.69101092
11MST1R2.42397991
12PRPF4B2.30936859
13PDGFRA2.14994349
14PAK62.05112660
15EPHB22.01967683
16MAP3K101.96607838
17PRKD31.95185137
18KSR11.89620560
19DDR21.86295502
20EEF2K1.81488900
21RIPK11.78378416
22SCYL21.77383904
23MINK11.74915812
24MAPK151.70666870
25TESK21.66309199
26NTRK31.63066513
27ICK1.61949801
28KSR21.57836923
29TYRO31.57469565
30MAP3K41.47290047
31TTN1.41259923
32NTRK11.36911375
33TAOK11.35809459
34NTRK21.34776833
35ALK1.33438864
36SIK21.31278029
37ARAF1.28080180
38PTK61.27512894
39PIM21.26869588
40PAK41.24564017
41MET1.23325486
42UHMK11.22513004
43DAPK21.21694122
44TAOK21.20653752
45EPHA41.20296333
46IRAK21.19560025
47SIK11.14935563
48PRKD21.12619574
49PHKG21.12342220
50PHKG11.12342220
51RET1.09706872
52MUSK1.08447632
53LATS11.07219254
54NEK11.06848281
55PTK21.02399033
56MAP2K31.00351060
57PAK20.99778342
58PAK30.99548172
59MAP3K110.99163350
60BMX0.95509564
61RPS6KB20.94491233
62ERBB30.94042519
63PDPK10.93860920
64MARK20.92423438
65BRAF0.90077051
66MTOR0.87760542
67MAP3K20.85526392
68FGFR10.85030779
69CDK140.83768099
70FER0.83013758
71CDK150.82765192
72CDK180.82514147
73ILK0.80416807
74ERBB20.79710301
75MAP2K20.79623137
76RPS6KC10.79432183
77RPS6KL10.79432183
78CDK50.78529535
79CAMK1D0.78021000
80TESK10.76064129
81DYRK20.74606368
82CDK70.74374034
83MAPK130.74345356
84RPS6KA20.74081008
85CDK11A0.72661448
86LMTK20.71593487
87LIMK10.69645447
88MAP3K80.69594532
89ABL20.69078016
90CDC42BPA0.67283527
91CDK40.66563960
92CDK120.66199405
93STK380.65592388
94PRKG20.64899975
95AURKA0.64750627
96DMPK0.64416306
97DAPK30.61441112
98STK110.61339454
99CDK80.60906425
100PDGFRB0.59262339
101FGFR20.58639762
102RPS6KA60.57116028
103CAMK1G0.55495089
104BUB10.55244355
105MAPK110.55034941
106MAP3K60.55004850
107ROCK10.54583600
108CHEK20.53735169
109PLK20.52528535
110MAP2K10.51635402
111EPHA20.51496029
112PRKCZ0.51464521
113DAPK10.50713625
114PRKCI0.50539763
115CSNK1G20.49938278
116ERN10.49302157
117BRSK10.49133440
118MAP2K40.48836125
119ROCK20.48742536
120CDK60.48319831
121MAP3K10.48101623
122PRKCH0.47865400
123MAPK90.45936777
124HIPK20.45665451
125FGFR40.45338661
126CSNK1E0.43652652
127MAPK120.40512077
128DYRK1B0.39726835
129TLK10.39490548
130PRKCG0.38192968
131CDC70.37607169
132NEK20.35991134
133KDR0.35576134
134AKT20.35303820
135MAP3K30.34699883
136PDK20.34553993
137CAMK2G0.34471589
138LRRK20.34314898
139TBK10.34271792
140CSNK1D0.33847861
141RPS6KA40.33479921
142FYN0.33141554
143RPS6KA10.31196018
144MAPK80.30726382
145SRC0.30466653
146PRKDC0.30256528
147PAK10.30233413
148CSNK1A1L0.29231377
149MAPK100.28908133
150MAP3K130.27897886
151CAMK2B0.27525850

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.95551705
2Other glycan degradation_Homo sapiens_hsa005112.14575415
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.04659307
4Basal cell carcinoma_Homo sapiens_hsa052172.04270460
5Fructose and mannose metabolism_Homo sapiens_hsa000511.97441402
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96663261
7Axon guidance_Homo sapiens_hsa043601.83098774
8Hippo signaling pathway_Homo sapiens_hsa043901.75457613
9Hedgehog signaling pathway_Homo sapiens_hsa043401.74318503
10Glioma_Homo sapiens_hsa052141.69316454
11Gap junction_Homo sapiens_hsa045401.67711937
12Endometrial cancer_Homo sapiens_hsa052131.64490530
13Synaptic vesicle cycle_Homo sapiens_hsa047211.64275822
14Long-term potentiation_Homo sapiens_hsa047201.63152724
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59963756
16Circadian entrainment_Homo sapiens_hsa047131.59882257
17Melanogenesis_Homo sapiens_hsa049161.57840615
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56273773
19Estrogen signaling pathway_Homo sapiens_hsa049151.55415090
20Dopaminergic synapse_Homo sapiens_hsa047281.53457896
21Pentose phosphate pathway_Homo sapiens_hsa000301.51583903
22Biosynthesis of amino acids_Homo sapiens_hsa012301.51348846
23Insulin secretion_Homo sapiens_hsa049111.50872538
24Bladder cancer_Homo sapiens_hsa052191.49224033
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.46898251
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46653135
27Amphetamine addiction_Homo sapiens_hsa050311.41788055
28Acute myeloid leukemia_Homo sapiens_hsa052211.40813081
29mTOR signaling pathway_Homo sapiens_hsa041501.40372209
30Cocaine addiction_Homo sapiens_hsa050301.38487589
31GnRH signaling pathway_Homo sapiens_hsa049121.38359524
32Vitamin B6 metabolism_Homo sapiens_hsa007501.36813676
33Cholinergic synapse_Homo sapiens_hsa047251.36482366
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.36113478
35Olfactory transduction_Homo sapiens_hsa047401.35285945
36Type II diabetes mellitus_Homo sapiens_hsa049301.33971083
37Colorectal cancer_Homo sapiens_hsa052101.32998624
38GABAergic synapse_Homo sapiens_hsa047271.28959611
39Glutamatergic synapse_Homo sapiens_hsa047241.28858270
40Proteoglycans in cancer_Homo sapiens_hsa052051.28307236
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27707234
42Dilated cardiomyopathy_Homo sapiens_hsa054141.26053475
43Gastric acid secretion_Homo sapiens_hsa049711.25944412
44Central carbon metabolism in cancer_Homo sapiens_hsa052301.25463400
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24185272
46Wnt signaling pathway_Homo sapiens_hsa043101.23866975
47Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.23120162
48Nicotine addiction_Homo sapiens_hsa050331.22728771
49Oxytocin signaling pathway_Homo sapiens_hsa049211.22445997
50Focal adhesion_Homo sapiens_hsa045101.22005259
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.21896916
52Chronic myeloid leukemia_Homo sapiens_hsa052201.20365475
53ErbB signaling pathway_Homo sapiens_hsa040121.19417653
54DNA replication_Homo sapiens_hsa030301.18895475
55Dorso-ventral axis formation_Homo sapiens_hsa043201.16270565
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16125314
57MicroRNAs in cancer_Homo sapiens_hsa052061.15369596
58Base excision repair_Homo sapiens_hsa034101.14826224
59Renal cell carcinoma_Homo sapiens_hsa052111.14223523
60Salivary secretion_Homo sapiens_hsa049701.13901802
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.13556248
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.12220959
63Non-small cell lung cancer_Homo sapiens_hsa052231.11357133
64Oocyte meiosis_Homo sapiens_hsa041141.11234440
65Morphine addiction_Homo sapiens_hsa050321.11064987
66Adherens junction_Homo sapiens_hsa045201.08613724
67VEGF signaling pathway_Homo sapiens_hsa043701.07562708
68Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.07474451
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06426378
70Lysine degradation_Homo sapiens_hsa003101.05706000
71Tight junction_Homo sapiens_hsa045301.05063265
72Notch signaling pathway_Homo sapiens_hsa043301.04541003
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03944726
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02393069
75Galactose metabolism_Homo sapiens_hsa000521.00840808
76Lysosome_Homo sapiens_hsa041421.00154364
77Long-term depression_Homo sapiens_hsa047300.98819259
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97226296
79Renin secretion_Homo sapiens_hsa049240.96128488
80Alcoholism_Homo sapiens_hsa050340.95528338
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.94165382
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93936039
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93931090
84ECM-receptor interaction_Homo sapiens_hsa045120.93108127
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93092077
86N-Glycan biosynthesis_Homo sapiens_hsa005100.89776379
87Insulin signaling pathway_Homo sapiens_hsa049100.87946957
88Rap1 signaling pathway_Homo sapiens_hsa040150.86708042
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85961270
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85286284
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83025203
92Melanoma_Homo sapiens_hsa052180.82662454
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82336744
94Cell cycle_Homo sapiens_hsa041100.81354709
95Vibrio cholerae infection_Homo sapiens_hsa051100.81266386
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.81188916
97cAMP signaling pathway_Homo sapiens_hsa040240.80110223
98Glucagon signaling pathway_Homo sapiens_hsa049220.80038678
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79724760
100Thyroid cancer_Homo sapiens_hsa052160.78854366
101Amoebiasis_Homo sapiens_hsa051460.76027201
102mRNA surveillance pathway_Homo sapiens_hsa030150.75785873
103Pancreatic cancer_Homo sapiens_hsa052120.74040225
104Thyroid hormone synthesis_Homo sapiens_hsa049180.73696860
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72892095
106MAPK signaling pathway_Homo sapiens_hsa040100.72315264
107Viral myocarditis_Homo sapiens_hsa054160.71328690
108Inositol phosphate metabolism_Homo sapiens_hsa005620.70704244
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70146707
110Pathways in cancer_Homo sapiens_hsa052000.69562812
111Apoptosis_Homo sapiens_hsa042100.69449979
112AMPK signaling pathway_Homo sapiens_hsa041520.69087284
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68860173
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68292792
115Taste transduction_Homo sapiens_hsa047420.67593104
116Small cell lung cancer_Homo sapiens_hsa052220.67311875
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66676984
118Prostate cancer_Homo sapiens_hsa052150.66615786
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65868445
120Viral carcinogenesis_Homo sapiens_hsa052030.64966719
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.63919493
122Carbon metabolism_Homo sapiens_hsa012000.63850077
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63337646
124HTLV-I infection_Homo sapiens_hsa051660.62795434
125Serotonergic synapse_Homo sapiens_hsa047260.62006305
126Protein digestion and absorption_Homo sapiens_hsa049740.61741024
127TGF-beta signaling pathway_Homo sapiens_hsa043500.61600207
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.61499939
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60568459
130Prion diseases_Homo sapiens_hsa050200.60424556
131Endocytosis_Homo sapiens_hsa041440.59693596
132Calcium signaling pathway_Homo sapiens_hsa040200.59024688
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58586360
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.58069187
135Salmonella infection_Homo sapiens_hsa051320.55970152
136Pyrimidine metabolism_Homo sapiens_hsa002400.54533551
137Insulin resistance_Homo sapiens_hsa049310.54456441
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52992273
139Shigellosis_Homo sapiens_hsa051310.52750223
140Choline metabolism in cancer_Homo sapiens_hsa052310.51875411
141Hepatitis C_Homo sapiens_hsa051600.50288823

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