LRFN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.75385962
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.69502813
3locomotory exploration behavior (GO:0035641)4.49673420
4regulation of short-term neuronal synaptic plasticity (GO:0048172)4.34427786
5regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.12932440
6layer formation in cerebral cortex (GO:0021819)4.07833220
7pyrimidine nucleobase catabolic process (GO:0006208)3.78007327
8Golgi transport vesicle coating (GO:0048200)3.70149260
9COPI coating of Golgi vesicle (GO:0048205)3.70149260
10glutamate secretion (GO:0014047)3.68460417
11vocalization behavior (GO:0071625)3.67785960
12cerebellar Purkinje cell layer development (GO:0021680)3.67568955
13response to pheromone (GO:0019236)3.65735078
14synaptic vesicle exocytosis (GO:0016079)3.56127802
15regulation of synaptic vesicle exocytosis (GO:2000300)3.53114521
16regulation of respiratory system process (GO:0044065)3.52978181
17positive regulation of synapse assembly (GO:0051965)3.49691416
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.44228179
19axon extension (GO:0048675)3.43666108
20establishment of mitochondrion localization (GO:0051654)3.39629664
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.37178967
22lymph vessel development (GO:0001945)3.35697568
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.35419690
24exploration behavior (GO:0035640)3.32422412
25axon extension involved in axon guidance (GO:0048846)3.31912799
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.31912799
27ganglion development (GO:0061548)3.27043981
28neurotransmitter secretion (GO:0007269)3.23954148
29regulation of glutamate receptor signaling pathway (GO:1900449)3.21442984
30activation of protein kinase A activity (GO:0034199)3.19061394
31dendrite morphogenesis (GO:0048813)3.17562460
32dendritic spine morphogenesis (GO:0060997)3.15807145
33nucleobase catabolic process (GO:0046113)3.13205562
34innervation (GO:0060384)3.13066298
35neuron cell-cell adhesion (GO:0007158)3.12831248
36presynaptic membrane assembly (GO:0097105)3.11432399
37regulation of synapse structural plasticity (GO:0051823)3.11275873
38protein heterotrimerization (GO:0070208)3.10572631
39growth hormone secretion (GO:0030252)3.09852006
40cell communication by electrical coupling (GO:0010644)3.07965211
41ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.07612086
42negative regulation of axon extension involved in axon guidance (GO:0048843)3.07208551
43cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.06991362
44regulation of synaptic vesicle transport (GO:1902803)3.06484866
45planar cell polarity pathway involved in neural tube closure (GO:0090179)3.05908396
46semaphorin-plexin signaling pathway (GO:0071526)3.04571665
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.04468951
48mitochondrion transport along microtubule (GO:0047497)3.04468951
49regulation of neuronal synaptic plasticity (GO:0048168)3.03784260
50regulation of axon extension involved in axon guidance (GO:0048841)3.01640408
51protein localization to synapse (GO:0035418)3.00244426
52proline transport (GO:0015824)2.99853631
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.99562411
54negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95391101
55positive regulation of synapse maturation (GO:0090129)2.94896373
56protein retention in ER lumen (GO:0006621)2.94517674
57regulation of long-term neuronal synaptic plasticity (GO:0048169)2.94225188
58negative regulation of catenin import into nucleus (GO:0035414)2.92903184
59urinary tract smooth muscle contraction (GO:0014848)2.88148358
60sodium ion export (GO:0071436)2.83198777
61neuron projection extension (GO:1990138)2.82824224
62dopamine receptor signaling pathway (GO:0007212)2.82471590
63gamma-aminobutyric acid transport (GO:0015812)2.82113517
64cell-cell junction maintenance (GO:0045217)2.79472864
65neurotransmitter-gated ion channel clustering (GO:0072578)2.78296145
66regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.77904266
67cellular potassium ion homeostasis (GO:0030007)2.77769055
68presynaptic membrane organization (GO:0097090)2.75665940
69erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.72613507
70L-phenylalanine catabolic process (GO:0006559)2.72613507
71insulin secretion (GO:0030073)2.71813738
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.71393268
73pattern specification involved in kidney development (GO:0061004)2.71012896
74protein insertion into membrane (GO:0051205)2.70807736
75convergent extension (GO:0060026)2.70561354
76facial nerve structural organization (GO:0021612)2.69687354
77regulation of calcium ion-dependent exocytosis (GO:0017158)2.68264499
78cellular response to glucagon stimulus (GO:0071377)2.67447381
79alanine transport (GO:0032328)2.65769006
80neuron recognition (GO:0008038)2.63392531
81behavioral response to nicotine (GO:0035095)2.63391158
82erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.62968349
83L-phenylalanine metabolic process (GO:0006558)2.62968349
84positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61831890
85cell migration in hindbrain (GO:0021535)2.61799144
86negative regulation of axon extension (GO:0030517)2.60716064
87vesicle coating (GO:0006901)2.60076693
88positive regulation of dendritic spine development (GO:0060999)2.59959424
89endocrine pancreas development (GO:0031018)2.59678047
90axonal fasciculation (GO:0007413)2.58969469
91regulation of axon guidance (GO:1902667)2.58709124
92regulation of glycogen (starch) synthase activity (GO:2000465)2.58550446
93chemosensory behavior (GO:0007635)2.58441641
94regulation of respiratory gaseous exchange (GO:0043576)2.58322198
95inner ear receptor cell development (GO:0060119)2.58124493
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.54876479
97cell junction maintenance (GO:0034331)2.54367532
98response to gravity (GO:0009629)2.53193793
99positive regulation of action potential (GO:0045760)2.53115383
100establishment or maintenance of monopolar cell polarity (GO:0061339)2.51548756
101establishment of monopolar cell polarity (GO:0061162)2.51548756
102nitric oxide mediated signal transduction (GO:0007263)2.51346702
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.51340918
104neuromuscular process controlling balance (GO:0050885)2.50860152
105macroautophagy (GO:0016236)2.48360664
106adenine nucleotide transport (GO:0051503)2.47729731
107negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47514532
108regulation of synapse assembly (GO:0051963)2.46472086
109regulation of synapse maturation (GO:0090128)2.46054492
110response to dietary excess (GO:0002021)2.44930742
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.44420004
112membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.44034115
113regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43254253
114postsynaptic membrane organization (GO:0001941)2.42970636
115suckling behavior (GO:0001967)2.42307468
116cerebellar granule cell differentiation (GO:0021707)2.42142152
117positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.41842241
118cellular response to prostaglandin stimulus (GO:0071379)2.41495953
119alpha-linolenic acid metabolic process (GO:0036109)2.40652048
120negative regulation of axon guidance (GO:1902668)2.39847813
121regulation of cholesterol homeostasis (GO:2000188)2.39519064
122neurotransmitter transport (GO:0006836)2.39139442
123activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38807460
124regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.38454255
125auditory behavior (GO:0031223)2.38289970
126regulation of ARF protein signal transduction (GO:0032012)2.37920236
127ionotropic glutamate receptor signaling pathway (GO:0035235)2.37644152
128neuromuscular process controlling posture (GO:0050884)2.37418869
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.37408852
130positive regulation of membrane potential (GO:0045838)2.36931263
131negative regulation of cell size (GO:0045792)2.36408245
132positive regulation of insulin secretion (GO:0032024)2.36207186
133positive regulation of exocytosis (GO:0045921)2.35899627
134vascular endothelial growth factor signaling pathway (GO:0038084)2.35414011
135synaptic transmission, glutamatergic (GO:0035249)2.35372541
136neuronal ion channel clustering (GO:0045161)2.34276896
137synapse assembly (GO:0007416)2.33920112
138cochlea morphogenesis (GO:0090103)2.33919367
139startle response (GO:0001964)2.33719206
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.33443537
141calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.33354928
142camera-type eye morphogenesis (GO:0048593)2.33148281
143neuronal action potential propagation (GO:0019227)2.33003110
144cranial nerve morphogenesis (GO:0021602)2.32595685
145cell communication involved in cardiac conduction (GO:0086065)2.31399861
146collecting duct development (GO:0072044)2.31331982
147adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.30944977
148regulation of axon extension (GO:0030516)2.30592696
149spinal cord development (GO:0021510)2.30279300
150synaptic vesicle endocytosis (GO:0048488)2.30271007
151signal release (GO:0023061)2.30134795
152glycine transport (GO:0015816)2.29940361
153mating behavior (GO:0007617)2.29393667
154regulation of neurotransmitter levels (GO:0001505)2.29206934
155dendritic spine organization (GO:0097061)2.28871269
156regulation of synaptic plasticity (GO:0048167)2.28339855
157regulation of synapse organization (GO:0050807)2.28172070
158axon cargo transport (GO:0008088)2.27892374
159positive regulation of nitric-oxide synthase activity (GO:0051000)2.27499114
160vesicle transport along microtubule (GO:0047496)2.26895345
161synapse organization (GO:0050808)2.26394619
162cerebellum development (GO:0021549)2.26258337
163protein maturation by protein folding (GO:0022417)2.24884221
164detection of calcium ion (GO:0005513)2.24792466
165triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.24532134
166cerebellar Purkinje cell differentiation (GO:0021702)2.24239347
167organelle transport along microtubule (GO:0072384)2.22802477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.39565885
2EZH2_22144423_ChIP-Seq_EOC_Human3.93296788
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.56210442
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50296685
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47617050
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.43358170
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.43065249
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.41557315
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.38490082
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36683600
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.34630001
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.30349937
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.29225733
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.29225733
15DROSHA_22980978_ChIP-Seq_HELA_Human2.28110898
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25511305
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.17560653
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.16288965
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.16097990
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15528840
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14619152
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10331693
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08423915
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.07953568
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07933899
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07788069
27GBX2_23144817_ChIP-Seq_PC3_Human2.05508440
28* REST_18959480_ChIP-ChIP_MESCs_Mouse2.03922161
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.96055673
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.93936801
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.93194138
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.91413547
33* RXR_22158963_ChIP-Seq_LIVER_Mouse1.87505044
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85830955
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.78208769
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.76711206
37* ELK3_25401928_ChIP-Seq_HUVEC_Human1.72530891
38P68_20966046_ChIP-Seq_HELA_Human1.69778433
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.58305025
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.55883012
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55192153
42* KDM2B_26808549_Chip-Seq_K562_Human1.54438996
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.53521984
44TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52444147
45TP53_22127205_ChIP-Seq_IMR90_Human1.50374616
46SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47880138
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47391534
48UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47356451
49RACK7_27058665_Chip-Seq_MCF-7_Human1.47067006
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46755626
51KDM2B_26808549_Chip-Seq_DND41_Human1.44665504
52ZNF274_21170338_ChIP-Seq_K562_Hela1.43086599
53* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.42678330
54* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41984543
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41829058
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41537507
57MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.41250766
58* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39145488
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38801319
60SA1_27219007_Chip-Seq_ERYTHROID_Human1.36003026
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.35743367
62OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31309860
63LXR_22292898_ChIP-Seq_THP-1_Human1.30717486
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.28767375
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26179301
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25216857
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22062813
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21616694
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21153244
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20799713
71ELF1_20517297_ChIP-Seq_JURKAT_Human1.19904559
72* AR_19668381_ChIP-Seq_PC3_Human1.18512865
73CTCF_27219007_Chip-Seq_Bcells_Human1.18360024
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17709432
75RING1B_27294783_Chip-Seq_NPCs_Mouse1.17660105
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16302299
77AR_21572438_ChIP-Seq_LNCaP_Human1.15880628
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14888358
79SOX2_21211035_ChIP-Seq_LN229_Gbm1.13071803
80* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.12959597
81SA1_27219007_Chip-Seq_Bcells_Human1.12880770
82OCT4_19829295_ChIP-Seq_ESCs_Human1.11208592
83E2F1_20622854_ChIP-Seq_HELA_Human1.11181820
84STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10770081
85SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10398293
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10303969
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09902666
88TP63_22573176_ChIP-Seq_HFKS_Human1.08691395
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08625022
90VDR_21846776_ChIP-Seq_THP-1_Human1.08190489
91* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08094893
92* TP53_23651856_ChIP-Seq_MEFs_Mouse1.07911261
93PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.06491096
94TET1_21490601_ChIP-Seq_MESCs_Mouse1.06439901
95BCL6_27268052_Chip-Seq_Bcells_Human1.06311025
96PHF8_20622854_ChIP-Seq_HELA_Human1.05932165
97CTCF_20526341_ChIP-Seq_ESCs_Human1.05250710
98TP53_20018659_ChIP-ChIP_R1E_Mouse1.04670508
99BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04351264
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.04309064
101* FOXP1_21924763_ChIP-Seq_HESCs_Human1.03854193
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03825783
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03459478
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02873646
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.00333186
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99890254
107RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99721755
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99145122
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98484976
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98083794
111CREB1_26743006_Chip-Seq_LNCaP_Human0.97785377
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97495340
113FOXA2_19822575_ChIP-Seq_HepG2_Human0.97333435
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96763251
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96274376
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95583887
117SMAD4_21799915_ChIP-Seq_A2780_Human0.95551807
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.94950973
119GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94765595
120ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94764144
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93019511
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92423246
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.90535842
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.90017542
125KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89225789
126KLF4_19829295_ChIP-Seq_ESCs_Human0.89114810
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89104982
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87624185
129ZNF263_19887448_ChIP-Seq_K562_Human0.87414066
130AHR_22903824_ChIP-Seq_MCF-7_Human0.85948327
131STAT3_23295773_ChIP-Seq_U87_Human0.85794427
132CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85439868
133ISL1_27105846_Chip-Seq_CPCs_Mouse0.85018325
134ARNT_22903824_ChIP-Seq_MCF-7_Human0.84436254
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.83100865
136SMC4_20622854_ChIP-Seq_HELA_Human0.80948155
137SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78617789
138CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77952902
139RXR_22108803_ChIP-Seq_LS180_Human0.77796682
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76664859
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.76485400
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75962745

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.55520343
2MP0003283_abnormal_digestive_organ3.24934867
3MP0004270_analgesia3.19775796
4MP0009780_abnormal_chondrocyte_physiolo3.13611491
5MP0002909_abnormal_adrenal_gland2.91243676
6MP0003635_abnormal_synaptic_transmissio2.89377100
7MP0002139_abnormal_hepatobiliary_system2.56198965
8MP0002063_abnormal_learning/memory/cond2.31586357
9MP0002249_abnormal_larynx_morphology2.29116472
10MP0005365_abnormal_bile_salt2.19410045
11MP0004858_abnormal_nervous_system2.17310681
12MP0005623_abnormal_meninges_morphology2.07229106
13MP0003122_maternal_imprinting2.04225406
14MP0005257_abnormal_intraocular_pressure2.02553107
15MP0010030_abnormal_orbit_morphology1.99757107
16MP0005085_abnormal_gallbladder_physiolo1.98900127
17MP0005360_urolithiasis1.98156640
18MP0003329_amyloid_beta_deposits1.97515785
19MP0002734_abnormal_mechanical_nocicepti1.93122686
20MP0000013_abnormal_adipose_tissue1.91979817
21MP0003880_abnormal_central_pattern1.88973876
22MP0000566_synostosis1.88884215
23MP0003195_calcinosis1.87170049
24MP0010368_abnormal_lymphatic_system1.84810938
25MP0009745_abnormal_behavioral_response1.83217353
26MP0002572_abnormal_emotion/affect_behav1.78205171
27MP0002064_seizures1.75521849
28MP0008961_abnormal_basal_metabolism1.74507310
29MP0002733_abnormal_thermal_nociception1.74293802
30MP0009053_abnormal_anal_canal1.73325380
31MP0000049_abnormal_middle_ear1.71942834
32MP0001188_hyperpigmentation1.70558604
33MP0004043_abnormal_pH_regulation1.70082560
34MP0005423_abnormal_somatic_nervous1.69587344
35MP0001968_abnormal_touch/_nociception1.67680751
36MP0003252_abnormal_bile_duct1.65121084
37MP0005503_abnormal_tendon_morphology1.64385534
38MP0000537_abnormal_urethra_morphology1.63525642
39MP0001944_abnormal_pancreas_morphology1.59796997
40MP0002089_abnormal_postnatal_growth/wei1.53641629
41MP0002234_abnormal_pharynx_morphology1.53586004
42MP0002184_abnormal_innervation1.50166549
43MP0000955_abnormal_spinal_cord1.49877056
44MP0000751_myopathy1.45709174
45MP0010386_abnormal_urinary_bladder1.44928687
46MP0004811_abnormal_neuron_physiology1.42184551
47MP0003279_aneurysm1.41057767
48MP0005645_abnormal_hypothalamus_physiol1.40401715
49MP0000778_abnormal_nervous_system1.40314223
50MP0002932_abnormal_joint_morphology1.39977369
51MP0002735_abnormal_chemical_nociception1.39366215
52MP0002822_catalepsy1.38263190
53MP0009250_abnormal_appendicular_skeleto1.35959651
54MP0003942_abnormal_urinary_system1.35725551
55MP0002557_abnormal_social/conspecific_i1.33817739
56MP0001970_abnormal_pain_threshold1.33411810
57MP0002877_abnormal_melanocyte_morpholog1.33148071
58MP0002693_abnormal_pancreas_physiology1.33108995
59MP0002272_abnormal_nervous_system1.32955821
60MP0006276_abnormal_autonomic_nervous1.32444248
61MP0004272_abnormal_basement_membrane1.31007714
62MP0003879_abnormal_hair_cell1.30264320
63MP0010329_abnormal_lipoprotein_level1.27411489
64MP0002078_abnormal_glucose_homeostasis1.27111509
65MP0005409_darkened_coat_color1.25241489
66MP0001440_abnormal_grooming_behavior1.24655803
67MP0009046_muscle_twitch1.24256950
68MP0001486_abnormal_startle_reflex1.23791730
69MP0000678_abnormal_parathyroid_gland1.23587004
70MP0002837_dystrophic_cardiac_calcinosis1.22486952
71MP0001529_abnormal_vocalization1.22352127
72MP0009384_cardiac_valve_regurgitation1.22001240
73MP0001502_abnormal_circadian_rhythm1.21655653
74MP0005187_abnormal_penis_morphology1.21619586
75MP0003123_paternal_imprinting1.21213832
76MP0000579_abnormal_nail_morphology1.20620113
77MP0008438_abnormal_cutaneous_collagen1.20372689
78MP0003868_abnormal_feces_composition1.20074539
79MP0000750_abnormal_muscle_regeneration1.18641064
80MP0003119_abnormal_digestive_system1.18489090
81MP0008875_abnormal_xenobiotic_pharmacok1.15158495
82MP0005646_abnormal_pituitary_gland1.15148164
83MP0001958_emphysema1.14119804
84MP0003705_abnormal_hypodermis_morpholog1.13388390
85MP0003011_delayed_dark_adaptation1.12031965
86MP0005083_abnormal_biliary_tract1.10640873
87MP0002653_abnormal_ependyma_morphology1.10530589
88MP0002163_abnormal_gland_morphology1.10424062
89MP0002067_abnormal_sensory_capabilities1.09378477
90MP0001879_abnormal_lymphatic_vessel1.07227645
91MP0003172_abnormal_lysosome_physiology1.06683295
92MP0004924_abnormal_behavior1.06666639
93MP0005386_behavior/neurological_phenoty1.06666639
94MP0005508_abnormal_skeleton_morphology1.06627303
95MP0001984_abnormal_olfaction1.06313741
96MP0005499_abnormal_olfactory_system1.06213506
97MP0005394_taste/olfaction_phenotype1.06213506
98MP0001299_abnormal_eye_distance/1.05517739
99MP0004130_abnormal_muscle_cell1.04904255
100MP0003861_abnormal_nervous_system1.04243432
101MP0000604_amyloidosis1.04060463
102MP0002736_abnormal_nociception_after1.03925807
103MP0000003_abnormal_adipose_tissue1.02932473
104MP0003385_abnormal_body_wall1.02803588
105MP0002116_abnormal_craniofacial_bone1.02625731
106MP0002882_abnormal_neuron_morphology1.02519424
107MP0005220_abnormal_exocrine_pancreas1.02445851
108MP0004885_abnormal_endolymph1.00940917
109MP0001501_abnormal_sleep_pattern1.00752132
110MP0001905_abnormal_dopamine_level1.00496527
111MP0000462_abnormal_digestive_system0.99111719
112MP0002069_abnormal_eating/drinking_beha0.98910225
113MP0009840_abnormal_foam_cell0.98855598
114MP0002066_abnormal_motor_capabilities/c0.98575637
115MP0005535_abnormal_body_temperature0.98223309
116MP0002896_abnormal_bone_mineralization0.96463415
117MP0000631_abnormal_neuroendocrine_gland0.93712013
118MP0001666_abnormal_nutrient_absorption0.93205808
119MP0003787_abnormal_imprinting0.91823813
120MP0005670_abnormal_white_adipose0.90843235
121MP0008569_lethality_at_weaning0.90529398
122MP0004233_abnormal_muscle_weight0.90067111
123MP0001270_distended_abdomen0.89957599
124MP0004133_heterotaxia0.89085774
125MP0002152_abnormal_brain_morphology0.88911424
126MP0001348_abnormal_lacrimal_gland0.88879662
127MP0003633_abnormal_nervous_system0.88565365
128MP0002118_abnormal_lipid_homeostasis0.88424576
129MP0002752_abnormal_somatic_nervous0.87924820
130MP0000534_abnormal_ureter_morphology0.86437245
131MP0003953_abnormal_hormone_level0.85986320
132MP0008789_abnormal_olfactory_epithelium0.85377121
133MP0004185_abnormal_adipocyte_glucose0.84939266
134MP0000681_abnormal_thyroid_gland0.84888736
135MP0009379_abnormal_foot_pigmentation0.83350277
136MP0004145_abnormal_muscle_electrophysio0.83062306
137MP0000467_abnormal_esophagus_morphology0.81755016
138MP0005448_abnormal_energy_balance0.81341526
139MP0000538_abnormal_urinary_bladder0.81197520
140MP0000639_abnormal_adrenal_gland0.81062508
141MP0002090_abnormal_vision0.80398205
142MP0001664_abnormal_digestion0.79674233
143MP0010234_abnormal_vibrissa_follicle0.78989974
144MP0000569_abnormal_digit_pigmentation0.78831675
145MP0006072_abnormal_retinal_apoptosis0.78466496
146MP0000762_abnormal_tongue_morphology0.77744003
147MP0003634_abnormal_glial_cell0.77131298
148MP0002638_abnormal_pupillary_reflex0.73276927
149MP0005332_abnormal_amino_acid0.72243177
150MP0004085_abnormal_heartbeat0.70629016

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.95907465
2Visual hallucinations (HP:0002367)3.75337589
3Hyperinsulinemic hypoglycemia (HP:0000825)3.75251838
4Hypoglycemic seizures (HP:0002173)3.70611554
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.59186538
6Ketoacidosis (HP:0001993)3.31460035
7Agitation (HP:0000713)3.25982886
8Hypoglycemic coma (HP:0001325)3.22377495
9Focal motor seizures (HP:0011153)3.20945472
10Ulnar bowing (HP:0003031)3.17078721
11Elfin facies (HP:0004428)3.13281430
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.11334290
13Bladder diverticulum (HP:0000015)3.03539905
14Supranuclear gaze palsy (HP:0000605)3.01598778
15Shallow orbits (HP:0000586)2.98854351
16Focal seizures (HP:0007359)2.95853752
17EEG with generalized epileptiform discharges (HP:0011198)2.94965995
18Hypsarrhythmia (HP:0002521)2.88670878
19Symptomatic seizures (HP:0011145)2.88185032
20Protrusio acetabuli (HP:0003179)2.87877880
21Premature rupture of membranes (HP:0001788)2.87355029
22Epileptiform EEG discharges (HP:0011182)2.87174886
23Deep venous thrombosis (HP:0002625)2.83892213
24Papilledema (HP:0001085)2.83091066
25Late onset (HP:0003584)2.82830943
26Broad metatarsal (HP:0001783)2.80048428
27Obstructive sleep apnea (HP:0002870)2.79246013
28Cerebral inclusion bodies (HP:0100314)2.76951781
29Overriding aorta (HP:0002623)2.74527237
30Abnormality of the lower motor neuron (HP:0002366)2.73000791
31Abnormality of the pancreatic islet cells (HP:0006476)2.71658085
32Abnormality of endocrine pancreas physiology (HP:0012093)2.71658085
33Renal duplication (HP:0000075)2.71480739
34Torticollis (HP:0000473)2.70752393
35Action tremor (HP:0002345)2.69783731
36Abnormality of the phalanges of the hallux (HP:0010057)2.65349715
37Genu recurvatum (HP:0002816)2.59942543
38Depression (HP:0000716)2.58056053
39Neurofibrillary tangles (HP:0002185)2.56607002
40Hyperglycemia (HP:0003074)2.54472905
41Renovascular hypertension (HP:0100817)2.52490680
42Ketosis (HP:0001946)2.52152718
43Ankle clonus (HP:0011448)2.51561164
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.51041030
45Bowed forearm bones (HP:0003956)2.49330770
46Bowing of the arm (HP:0006488)2.49330770
47Absence seizures (HP:0002121)2.46425420
48Aplasia involving bones of the upper limbs (HP:0009823)2.45651333
49Aplasia of the phalanges of the hand (HP:0009802)2.45651333
50Aplasia involving bones of the extremities (HP:0009825)2.45651333
51Epileptic encephalopathy (HP:0200134)2.42663019
52Turricephaly (HP:0000262)2.42163168
53Generalized tonic-clonic seizures (HP:0002069)2.41649996
54Insomnia (HP:0100785)2.40723888
55Stridor (HP:0010307)2.40027349
56Megalocornea (HP:0000485)2.37539222
57Ankle contracture (HP:0006466)2.37536323
58Focal dystonia (HP:0004373)2.36500711
59Failure to thrive in infancy (HP:0001531)2.36185644
60Coronal craniosynostosis (HP:0004440)2.33197235
61Xanthomatosis (HP:0000991)2.32384481
62Flat cornea (HP:0007720)2.31295091
63Craniofacial dystonia (HP:0012179)2.27256201
64Intrahepatic cholestasis (HP:0001406)2.27115218
65Pheochromocytoma (HP:0002666)2.25655319
66Anxiety (HP:0000739)2.25482969
67High anterior hairline (HP:0009890)2.24829128
68Abnormality of the aortic arch (HP:0012303)2.23071687
69Hepatoblastoma (HP:0002884)2.22692950
70Bowel diverticulosis (HP:0005222)2.22372378
71Abnormality of calcium-phosphate metabolism (HP:0100530)2.21951856
72Hypercortisolism (HP:0001578)2.20435629
73Abnormality of the intervertebral disk (HP:0005108)2.18168637
74Skin nodule (HP:0200036)2.17063199
75Disproportionate tall stature (HP:0001519)2.16258543
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.15554950
77Drooling (HP:0002307)2.14927472
78Excessive salivation (HP:0003781)2.14927472
79Impaired social interactions (HP:0000735)2.14359357
80Abnormal social behavior (HP:0012433)2.14359357
81Progressive cerebellar ataxia (HP:0002073)2.14192275
82Poor eye contact (HP:0000817)2.09953975
83Congenital glaucoma (HP:0001087)2.09505490
84Diastasis recti (HP:0001540)2.09286986
85Large for gestational age (HP:0001520)2.09078982
86Megalencephaly (HP:0001355)2.06517966
87Restlessness (HP:0000711)2.05872419
88Hemiparesis (HP:0001269)2.05177140
89Dialeptic seizures (HP:0011146)2.05115206
90Deviation of the hallux (HP:0010051)2.05072930
91Hallux valgus (HP:0001822)2.04257793
92Gout (HP:0001997)2.03973933
93Retinal atrophy (HP:0001105)2.03337320
94Abnormal eating behavior (HP:0100738)2.02288787
95Pancreatic islet-cell hyperplasia (HP:0004510)2.02246224
96Atonic seizures (HP:0010819)1.99940227
97Neoplasm of the heart (HP:0100544)1.99752557
98Spina bifida occulta (HP:0003298)1.99027544
99Anomalous pulmonary venous return (HP:0010772)1.98471097
100Macroorchidism (HP:0000053)1.98266415
101Abnormality of the 4th metacarpal (HP:0010012)1.96787004
102Infantile muscular hypotonia (HP:0008947)1.96359548
103Hyperventilation (HP:0002883)1.95652242
104Mutism (HP:0002300)1.95360600
105Large eyes (HP:0001090)1.95253961
106Genetic anticipation (HP:0003743)1.94719064
107Insulin-resistant diabetes mellitus (HP:0000831)1.94449227
108Pointed chin (HP:0000307)1.93295812
109Broad distal phalanx of finger (HP:0009836)1.93040393
110Limb dystonia (HP:0002451)1.90350627
111Urinary glycosaminoglycan excretion (HP:0003541)1.89254375
112Mucopolysacchariduria (HP:0008155)1.89254375
113Hypoventilation (HP:0002791)1.88691202
114Radial bowing (HP:0002986)1.87957270
115Abnormality of the distal phalanx of the thumb (HP:0009617)1.87155831
116Global brain atrophy (HP:0002283)1.86737020
117Polyphagia (HP:0002591)1.85970406
118Hand muscle atrophy (HP:0009130)1.85103114
119Abnormality of the pulmonary veins (HP:0011718)1.84460131
120Breast hypoplasia (HP:0003187)1.84392325
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84323394
122Abnormality of polysaccharide metabolism (HP:0011012)1.84323394
123Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84323394
124Abnormality of the diencephalon (HP:0010662)1.84225325
125Epidermoid cyst (HP:0200040)1.83892314
126Postural instability (HP:0002172)1.82542845
127Spinal rigidity (HP:0003306)1.80668135
128Impaired vibration sensation in the lower limbs (HP:0002166)1.80429210
129Long toe (HP:0010511)1.80038096
130Hyperacusis (HP:0010780)1.79042952
131Hydroureter (HP:0000072)1.78689976
132Rectal prolapse (HP:0002035)1.78619366
133Neonatal short-limb short stature (HP:0008921)1.78433267
134Adducted thumb (HP:0001181)1.77797924
135Long palpebral fissure (HP:0000637)1.77677118
136Slender build (HP:0001533)1.76651199
137Ankyloglossia (HP:0010296)1.76557832
138Status epilepticus (HP:0002133)1.76476509
139Sleep apnea (HP:0010535)1.76225194
140Clonus (HP:0002169)1.75445960
141Microretrognathia (HP:0000308)1.75411729
142Postural tremor (HP:0002174)1.74971766
143Partial duplication of the phalanx of hand (HP:0009999)1.74774018
144Mitral regurgitation (HP:0001653)1.74546572
145Morphological abnormality of the middle ear (HP:0008609)1.74533037
146Atrophic scars (HP:0001075)1.74143836
147Slender long bone (HP:0003100)1.74125250
148Coxa vara (HP:0002812)1.73966834
149Truncal ataxia (HP:0002078)1.73775797
150Distal upper limb amyotrophy (HP:0007149)1.73541051
151Upper limb amyotrophy (HP:0009129)1.73541051
152Abnormality of the distal phalanges of the toes (HP:0010182)1.73312422
153Abnormality of the common coagulation pathway (HP:0010990)1.73286962
154Conjugated hyperbilirubinemia (HP:0002908)1.72236371
155Amblyopia (HP:0000646)1.71941293
156Abnormality of the Achilles tendon (HP:0005109)1.71887766
157Neuroendocrine neoplasm (HP:0100634)1.71887470
158Pachygyria (HP:0001302)1.71497479
159Broad face (HP:0000283)1.71344256
160Dysdiadochokinesis (HP:0002075)1.71322501
161Morphological abnormality of the pyramidal tract (HP:0002062)1.71097186
162Spastic gait (HP:0002064)1.70596973
163Bronchomalacia (HP:0002780)1.70389617
164Achilles tendon contracture (HP:0001771)1.69797326
165Hyperparathyroidism (HP:0000843)1.68830796
166Aplasia/Hypoplasia of the patella (HP:0006498)1.68520310
167Precocious puberty (HP:0000826)1.66704322
168Fragile skin (HP:0001030)1.64517640
169Abnormality of the middle phalanges of the toes (HP:0010183)1.64268283
170Patellar aplasia (HP:0006443)1.63635728
171Hypoplasia of the brainstem (HP:0002365)1.61854071
172Aplasia/Hypoplasia of the brainstem (HP:0007362)1.61854071
173Patellar dislocation (HP:0002999)1.60734291
174Wrist flexion contracture (HP:0001239)1.60360066
175Partial duplication of thumb phalanx (HP:0009944)1.60031514
176Axonal loss (HP:0003447)1.59024268
177Arnold-Chiari malformation (HP:0002308)1.58879618
178Trigonocephaly (HP:0000243)1.58697993
179Type 1 muscle fiber predominance (HP:0003803)1.58487824
180Akinesia (HP:0002304)1.56760721
181Nonimmune hydrops fetalis (HP:0001790)1.56397662
182Abnormal number of incisors (HP:0011064)1.56074031
183Testicular atrophy (HP:0000029)1.56031626
184Annular pancreas (HP:0001734)1.55806826
185Distal lower limb amyotrophy (HP:0008944)1.55278708
186Short femoral neck (HP:0100864)1.55268126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.76734852
2MAP3K93.29735367
3NTRK33.15877360
4PRKD32.93711186
5CASK2.64352854
6MINK12.40716201
7EPHA42.29158209
8INSRR2.27709589
9NTRK12.22896943
10KSR22.21618778
11MAP3K42.12723513
12DAPK22.11589301
13KDR2.07059240
14PAK62.06058607
15EEF2K2.04824907
16MAP3K111.96825024
17TRIB31.96770323
18MAP3K21.93753593
19LATS21.81177844
20KSR11.77554107
21MAP2K41.77202626
22CAMKK11.76174040
23EPHA21.74729384
24NTRK21.65835031
25WNK31.64196779
26SMG11.62697951
27PDGFRA1.61676830
28LIMK11.56557436
29MAP2K21.52617056
30MAPK151.45890485
31RET1.37357793
32UHMK11.37085311
33TESK11.36645482
34TESK21.34929466
35ERN11.33989988
36PAK31.33631620
37MAP3K11.31378854
38PASK1.29512963
39RIPK11.25348674
40TLK11.24479648
41CDK51.23286004
42CSNK1G31.18929684
43PRKCH1.18319047
44SCYL21.16685163
45PHKG21.15784679
46PHKG11.15784679
47IRAK31.14636972
48MAP2K71.14233907
49PTK21.13981167
50HIPK21.07266061
51ARAF1.06849815
52SIK11.03245967
53PKN21.02733698
54CSNK1A1L1.02675331
55FRK1.01240980
56TAOK11.00108786
57PRKCG0.99140042
58TAOK30.98594237
59MARK20.97231531
60SIK20.96968469
61FER0.96883970
62TYRO30.96833726
63TTN0.95487746
64CAMKK20.93462099
65ICK0.92474333
66ABL20.90022508
67DAPK10.88161590
68CAMK1D0.80752978
69STK380.79564256
70ALK0.79452803
71PTK60.79287720
72CDC42BPA0.78793592
73MAPKAPK30.73979823
74GRK50.73935377
75CDK140.73154641
76PRKCZ0.73013498
77BRAF0.71854837
78MAP2K10.71332242
79CAMK1G0.70887780
80RPS6KA20.70210854
81CDK180.69950935
82CSNK1G10.69633931
83DDR20.68237676
84MAPK130.67880729
85FGFR40.67486982
86CDK150.66904024
87CSNK1G20.65785348
88DYRK20.64749316
89CAMK2B0.63959860
90STK110.63320945
91PNCK0.63108220
92EPHB10.61221618
93WNK40.61194369
94MAPK120.60464345
95EPHB20.58473867
96RPS6KA60.58392055
97PTK2B0.56792954
98GRK10.56674447
99CDK11A0.56474806
100CAMK2A0.55792067
101PRKG20.55741952
102ADRBK20.55569985
103SGK4940.55348126
104SGK2230.55348126
105DYRK1A0.55072319
106PRKD20.55034676
107PINK10.55020813
108FGFR20.54947300
109ERBB20.53538104
110SGK30.53374125
111DYRK1B0.52921412
112RPS6KC10.52072320
113RPS6KL10.52072320
114LMTK20.48449937
115IRAK20.47831388
116BCR0.46797311
117CAMK10.45534788
118PDPK10.45488704
119BCKDK0.44380538
120RPS6KA30.44334220
121PLK20.43850296
122MTOR0.43022150
123CAMK2G0.42745278
124EPHA30.42623513
125PRKCE0.42458163
126CAMK40.42303232
127PRPF4B0.41872991
128CDK80.40949290
129AKT20.40815468
130PRKAA10.40707825
131ADRBK10.40469054
132PRKACG0.40431362
133MAP3K70.40294233
134SIK30.40269083
135PRKCI0.40249937
136MAP3K100.39804223
137MAP3K120.38844602

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.61975226
2Sulfur relay system_Homo sapiens_hsa041222.86536445
3Nitrogen metabolism_Homo sapiens_hsa009102.84429945
4Insulin secretion_Homo sapiens_hsa049112.45248024
5Synaptic vesicle cycle_Homo sapiens_hsa047212.27930640
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16247562
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.08453622
8Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.04111565
9Basal cell carcinoma_Homo sapiens_hsa052171.90052274
10GABAergic synapse_Homo sapiens_hsa047271.84353436
11Type II diabetes mellitus_Homo sapiens_hsa049301.79269181
12Nicotine addiction_Homo sapiens_hsa050331.79054900
13Circadian entrainment_Homo sapiens_hsa047131.74968882
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.70201624
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64126130
16Amphetamine addiction_Homo sapiens_hsa050311.61901302
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61166974
18Long-term potentiation_Homo sapiens_hsa047201.59325095
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56753916
20Dopaminergic synapse_Homo sapiens_hsa047281.56358334
21Cocaine addiction_Homo sapiens_hsa050301.55757036
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54752656
23Hedgehog signaling pathway_Homo sapiens_hsa043401.53814847
24Phototransduction_Homo sapiens_hsa047441.53780816
25Hippo signaling pathway_Homo sapiens_hsa043901.50923606
26Glutamatergic synapse_Homo sapiens_hsa047241.50414285
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.49778221
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46231248
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.45929170
30Arginine biosynthesis_Homo sapiens_hsa002201.45057284
31Butanoate metabolism_Homo sapiens_hsa006501.41097189
32Bile secretion_Homo sapiens_hsa049761.40430123
33Cholinergic synapse_Homo sapiens_hsa047251.38507290
34Notch signaling pathway_Homo sapiens_hsa043301.38454986
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38375240
36Olfactory transduction_Homo sapiens_hsa047401.36997402
37Morphine addiction_Homo sapiens_hsa050321.32297714
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.32004364
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26191901
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.23852304
41Salivary secretion_Homo sapiens_hsa049701.21223224
42ECM-receptor interaction_Homo sapiens_hsa045121.18641776
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17414724
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14647399
45Gastric acid secretion_Homo sapiens_hsa049711.13851698
46Sulfur metabolism_Homo sapiens_hsa009201.12663681
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.09505397
48Tryptophan metabolism_Homo sapiens_hsa003801.09279435
49Gap junction_Homo sapiens_hsa045401.07750243
50Taste transduction_Homo sapiens_hsa047421.06713758
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06153616
52Prion diseases_Homo sapiens_hsa050201.05543000
53Vitamin B6 metabolism_Homo sapiens_hsa007501.04453416
54Estrogen signaling pathway_Homo sapiens_hsa049151.03058792
55Renin secretion_Homo sapiens_hsa049241.01750169
56Focal adhesion_Homo sapiens_hsa045101.01681662
57Linoleic acid metabolism_Homo sapiens_hsa005911.01550509
58Ras signaling pathway_Homo sapiens_hsa040140.96608555
59GnRH signaling pathway_Homo sapiens_hsa049120.96328871
60Ovarian steroidogenesis_Homo sapiens_hsa049130.95762155
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94664405
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94409262
63Vibrio cholerae infection_Homo sapiens_hsa051100.93820782
64MAPK signaling pathway_Homo sapiens_hsa040100.93004873
65Oxytocin signaling pathway_Homo sapiens_hsa049210.92155846
66Long-term depression_Homo sapiens_hsa047300.91055662
67Glucagon signaling pathway_Homo sapiens_hsa049220.90956829
68Glioma_Homo sapiens_hsa052140.89504833
69Wnt signaling pathway_Homo sapiens_hsa043100.88498132
70Rap1 signaling pathway_Homo sapiens_hsa040150.88287269
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88030735
72Melanoma_Homo sapiens_hsa052180.87535326
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.87257030
74Serotonergic synapse_Homo sapiens_hsa047260.86198065
75Melanogenesis_Homo sapiens_hsa049160.85796168
76Pancreatic secretion_Homo sapiens_hsa049720.85289492
77Thyroid hormone synthesis_Homo sapiens_hsa049180.84871787
78Axon guidance_Homo sapiens_hsa043600.82682144
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82335151
80Cardiac muscle contraction_Homo sapiens_hsa042600.80700943
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79334595
82Fat digestion and absorption_Homo sapiens_hsa049750.78910358
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78282673
84cAMP signaling pathway_Homo sapiens_hsa040240.74977616
85cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74155277
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73343093
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72991364
88mTOR signaling pathway_Homo sapiens_hsa041500.70697758
89Insulin signaling pathway_Homo sapiens_hsa049100.70508432
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67744392
91Endocytosis_Homo sapiens_hsa041440.67607972
92Complement and coagulation cascades_Homo sapiens_hsa046100.66799708
93Ether lipid metabolism_Homo sapiens_hsa005650.66480998
94Fatty acid degradation_Homo sapiens_hsa000710.66017150
95Calcium signaling pathway_Homo sapiens_hsa040200.64266873
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.63992630
97Insulin resistance_Homo sapiens_hsa049310.63463187
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63341379
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62980371
100ErbB signaling pathway_Homo sapiens_hsa040120.62765637
101Fatty acid metabolism_Homo sapiens_hsa012120.62266744
102Starch and sucrose metabolism_Homo sapiens_hsa005000.59615554
103Dorso-ventral axis formation_Homo sapiens_hsa043200.59473588
104Tight junction_Homo sapiens_hsa045300.59380409
105Protein digestion and absorption_Homo sapiens_hsa049740.58583988
106Endometrial cancer_Homo sapiens_hsa052130.57328267
107PPAR signaling pathway_Homo sapiens_hsa033200.55281242
108Choline metabolism in cancer_Homo sapiens_hsa052310.55074123
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.54561379
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54214269
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54194111
112Selenocompound metabolism_Homo sapiens_hsa004500.54004161
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53253948
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52367232
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.51722738
116Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50145109
117AMPK signaling pathway_Homo sapiens_hsa041520.48354937
118N-Glycan biosynthesis_Homo sapiens_hsa005100.48196130
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48172839
120Proteoglycans in cancer_Homo sapiens_hsa052050.47451693
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46958253
122Collecting duct acid secretion_Homo sapiens_hsa049660.46090848
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.44870965
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44822694
125Bladder cancer_Homo sapiens_hsa052190.44585606
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44142406
127Dilated cardiomyopathy_Homo sapiens_hsa054140.43628052
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43577284
129Colorectal cancer_Homo sapiens_hsa052100.43495961
130Lysine degradation_Homo sapiens_hsa003100.42933051
131Type I diabetes mellitus_Homo sapiens_hsa049400.42444364
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.42294865
133Phenylalanine metabolism_Homo sapiens_hsa003600.42043350
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.41735366
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.40538072
136ABC transporters_Homo sapiens_hsa020100.39570381
137Pathways in cancer_Homo sapiens_hsa052000.39508656
138Renal cell carcinoma_Homo sapiens_hsa052110.39358243
1392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.38227041
140Circadian rhythm_Homo sapiens_hsa047100.36645377
141VEGF signaling pathway_Homo sapiens_hsa043700.36246117
142Prolactin signaling pathway_Homo sapiens_hsa049170.35752328

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