LRFN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of T-helper cell differentiation (GO:0045623)9.46546530
2negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)9.46546530
3protein K11-linked deubiquitination (GO:0035871)9.39704577
4negative regulation of type 2 immune response (GO:0002829)8.81480698
5regulation of T-helper 2 cell differentiation (GO:0045628)8.78115214
6positive regulation of RNA splicing (GO:0033120)8.77490763
7regulation of T-helper 1 cell differentiation (GO:0045625)8.52219163
8seminiferous tubule development (GO:0072520)8.38315033
9cAMP biosynthetic process (GO:0006171)8.27031084
10negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)7.54519716
11detection of chemical stimulus involved in sensory perception (GO:0050907)7.26603650
12enteric nervous system development (GO:0048484)7.06166378
13positive regulation of mitochondrial fission (GO:0090141)6.93705018
14righting reflex (GO:0060013)6.88867596
15synaptic transmission, dopaminergic (GO:0001963)6.88219674
16negative regulation of alpha-beta T cell differentiation (GO:0046639)6.83531546
17regulation of protein sumoylation (GO:0033233)6.68317640
18synaptic vesicle maturation (GO:0016188)6.43359202
19regulation of short-term neuronal synaptic plasticity (GO:0048172)6.33275760
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.13927769
21locomotory exploration behavior (GO:0035641)6.03150811
22vocalization behavior (GO:0071625)6.00723572
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.95426579
24neuronal ion channel clustering (GO:0045161)5.80954712
25heterotypic cell-cell adhesion (GO:0034113)5.57103224
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56295289
27regulation of glutamate receptor signaling pathway (GO:1900449)5.41232439
28chemosensory behavior (GO:0007635)5.36375093
29detection of chemical stimulus (GO:0009593)5.31881996
30synaptic vesicle exocytosis (GO:0016079)5.25796982
31protein localization to synapse (GO:0035418)5.24238873
32glutamate secretion (GO:0014047)5.21312398
33synaptic vesicle docking involved in exocytosis (GO:0016081)5.18920387
34positive regulation of T-helper 1 type immune response (GO:0002827)5.16246613
35endothelial cell differentiation (GO:0045446)5.09816384
36regulation of mitochondrial fission (GO:0090140)5.06056948
37arachidonic acid secretion (GO:0050482)5.05780672
38icosanoid secretion (GO:0032309)5.05780672
39neuron cell-cell adhesion (GO:0007158)5.05666476
40exploration behavior (GO:0035640)5.03183574
41regulation of synaptic vesicle exocytosis (GO:2000300)4.97967448
42positive regulation of T-helper cell differentiation (GO:0045624)4.89858414
43ionotropic glutamate receptor signaling pathway (GO:0035235)4.77485348
44layer formation in cerebral cortex (GO:0021819)4.76896084
45response to dietary excess (GO:0002021)4.75178521
46phosphatidylinositol acyl-chain remodeling (GO:0036149)4.63121887
47hepatocyte apoptotic process (GO:0097284)4.61652340
48dendritic spine morphogenesis (GO:0060997)4.60352752
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.59676593
50gamma-aminobutyric acid transport (GO:0015812)4.55863988
51regulation of neuronal synaptic plasticity (GO:0048168)4.53896394
52ATP hydrolysis coupled proton transport (GO:0015991)4.50249798
53energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.50249798
54cellular response to glucagon stimulus (GO:0071377)4.48916642
55regulation of synaptic vesicle transport (GO:1902803)4.40872334
56synaptic transmission, glutamatergic (GO:0035249)4.39152625
57regulation of synapse structural plasticity (GO:0051823)4.34566908
58drug transmembrane transport (GO:0006855)4.33904143
59neurotransmitter-gated ion channel clustering (GO:0072578)4.33617491
60phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.33150852
61regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32565900
62postsynaptic membrane organization (GO:0001941)4.30480547
63phosphatidylserine acyl-chain remodeling (GO:0036150)4.30130219
64neurotransmitter secretion (GO:0007269)4.25846380
65cyclic purine nucleotide metabolic process (GO:0052652)4.24317849
66proline transport (GO:0015824)4.23389677
67cytoskeletal anchoring at plasma membrane (GO:0007016)4.22951849
68cAMP metabolic process (GO:0046058)4.17171653
69glutamate receptor signaling pathway (GO:0007215)4.16116576
70fatty acid derivative transport (GO:1901571)4.12951428
71icosanoid transport (GO:0071715)4.12951428
72negative regulation of cytosolic calcium ion concentration (GO:0051481)4.11280351
73positive regulation of membrane potential (GO:0045838)4.10402088
74cyclic nucleotide biosynthetic process (GO:0009190)4.07596499
75water transport (GO:0006833)4.05346242
76retina layer formation (GO:0010842)4.01018512
77regulation of cAMP-mediated signaling (GO:0043949)3.99410755
78positive regulation of synapse maturation (GO:0090129)3.99121883
79neuron recognition (GO:0008038)3.98351329
80neural tube formation (GO:0001841)3.97921125
81regulation of dendritic spine morphogenesis (GO:0061001)3.91435501
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.90060996
83cilium or flagellum-dependent cell motility (GO:0001539)3.88242266
84neuron-neuron synaptic transmission (GO:0007270)3.88086141
85presynaptic membrane assembly (GO:0097105)3.87035031
86long-term memory (GO:0007616)3.83268810
87axonal fasciculation (GO:0007413)3.82818335
88nephron epithelium morphogenesis (GO:0072088)3.80623209
89nephron tubule morphogenesis (GO:0072078)3.80623209
90neuromuscular process controlling posture (GO:0050884)3.79101950
91negative regulation of alpha-beta T cell activation (GO:0046636)3.78459057
92neurofilament cytoskeleton organization (GO:0060052)3.77037956
93mitochondrial fusion (GO:0008053)3.74917545
94dendrite morphogenesis (GO:0048813)3.74452063
95cellular potassium ion homeostasis (GO:0030007)3.73486691
96neuronal action potential propagation (GO:0019227)3.70577448
97regulation of postsynaptic membrane potential (GO:0060078)3.70506306
98hyaluronan catabolic process (GO:0030214)3.67501797
99regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66855966
100negative regulation of actin filament bundle assembly (GO:0032232)3.65458961
101positive regulation of protein targeting to membrane (GO:0090314)3.65350641
102monoamine transport (GO:0015844)3.64202892
103positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.61038883
104sodium ion export (GO:0071436)3.60877240
105regulation of T-helper 1 type immune response (GO:0002825)3.60208910
106embryonic digestive tract morphogenesis (GO:0048557)3.57789551
107fluid transport (GO:0042044)3.57445288
108regulation of type 2 immune response (GO:0002828)3.56600148
109regulation of synaptic plasticity (GO:0048167)3.56011949
110positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50435921
111activation of protein kinase A activity (GO:0034199)3.49411555
112regulation of neurotransmitter secretion (GO:0046928)3.49023108
113cellular potassium ion transport (GO:0071804)3.48687883
114potassium ion transmembrane transport (GO:0071805)3.48687883
115neuromuscular process controlling balance (GO:0050885)3.47911661
116presynaptic membrane organization (GO:0097090)3.45251783
117regulation of T-helper cell differentiation (GO:0045622)3.45026197
118neurotransmitter transport (GO:0006836)3.42967534
119positive regulation of synaptic transmission, GABAergic (GO:0032230)3.40984013
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.40609948
121cell communication by electrical coupling (GO:0010644)3.40445895
122synaptic vesicle endocytosis (GO:0048488)3.39021387
123regulation of dendritic spine development (GO:0060998)3.37994266
124transmission of nerve impulse (GO:0019226)3.37764927
125cellular response to ATP (GO:0071318)3.35845764
126response to glucagon (GO:0033762)3.35055708
127membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.34066508
128adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)3.32883155
129dendritic spine organization (GO:0097061)3.29403384
130vesicle transport along microtubule (GO:0047496)3.29358722
131cell migration in hindbrain (GO:0021535)3.28865990
132regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.27425760
133G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.26734868
134negative regulation of astrocyte differentiation (GO:0048712)3.25795613
135innervation (GO:0060384)3.24784750
136positive regulation of dendritic spine development (GO:0060999)3.24421907
137response to auditory stimulus (GO:0010996)3.24316843
138regulation of synaptic transmission, glutamatergic (GO:0051966)3.24270939
139positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.23161338
140attachment of spindle microtubules to kinetochore (GO:0008608)3.22550627
141positive regulation of neurotransmitter secretion (GO:0001956)3.21990481
142cellular zinc ion homeostasis (GO:0006882)3.21443810
143auditory behavior (GO:0031223)3.21060356
144regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.20893928
145regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.20893928
146intraspecies interaction between organisms (GO:0051703)3.19810889
147social behavior (GO:0035176)3.19810889
148central nervous system projection neuron axonogenesis (GO:0021952)3.19312961
149organelle transport along microtubule (GO:0072384)3.18465414
150L-amino acid import (GO:0043092)3.18394640
151positive regulation of dendritic spine morphogenesis (GO:0061003)3.17134267
152regulation of vesicle fusion (GO:0031338)3.17083958
153pre-miRNA processing (GO:0031054)3.16030158
154regulation of neurotransmitter levels (GO:0001505)3.11431224
155positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.11280896
156gamma-aminobutyric acid signaling pathway (GO:0007214)3.10052900
157synapse assembly (GO:0007416)3.09617457
158phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.09568276
159long-term synaptic potentiation (GO:0060291)3.08361441
160regulation of neurotransmitter transport (GO:0051588)3.07117705
161cerebellar Purkinje cell layer development (GO:0021680)3.06799069
162adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)3.06720939
163reflex (GO:0060004)3.06429785
164membrane hyperpolarization (GO:0060081)3.06368483
165regulation of protein targeting to membrane (GO:0090313)3.05950543
166activation of phospholipase C activity (GO:0007202)3.05633785
167membrane depolarization (GO:0051899)3.05390217
168learning (GO:0007612)3.04340920
169positive regulation of neurotransmitter transport (GO:0051590)3.03704991
170regulation of synapse maturation (GO:0090128)3.03444328
171behavioral fear response (GO:0001662)3.00759657
172behavioral defense response (GO:0002209)3.00759657
173leukotriene biosynthetic process (GO:0019370)2.98570644
174renal tubule morphogenesis (GO:0061333)2.98369716
175cerebellar Purkinje cell differentiation (GO:0021702)2.96706800
176regulation of synaptic transmission (GO:0050804)2.96182598
177regulation of ARF protein signal transduction (GO:0032012)2.94874598
178glycine transport (GO:0015816)2.94670852
179response to histamine (GO:0034776)2.94143690
180G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.93078627
181positive regulation of synaptic transmission (GO:0050806)2.90906151
182neuromuscular process (GO:0050905)2.90001991
183membrane depolarization during action potential (GO:0086010)2.88749084
184tooth mineralization (GO:0034505)12.1282119
185detection of chemical stimulus involved in sensory perception of smell (GO:0050911)11.7392109
186positive regulation of protein sumoylation (GO:0033235)10.7267259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse9.11490846
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.10830037
3EZH2_22144423_ChIP-Seq_EOC_Human6.01352223
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.01919700
5VDR_22108803_ChIP-Seq_LS180_Human3.36824682
6GBX2_23144817_ChIP-Seq_PC3_Human3.30130039
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14054719
8JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10092314
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.05025348
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89616974
11* REST_21632747_ChIP-Seq_MESCs_Mouse2.78722350
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73035416
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73035416
14DROSHA_22980978_ChIP-Seq_HELA_Human2.69102129
15* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66478326
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58748828
17* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58140434
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.55608697
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.55475271
20* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55451252
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.53437775
22* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40185423
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.39739082
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.39206963
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.37665157
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.29098837
27* REST_18959480_ChIP-ChIP_MESCs_Mouse2.28488354
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.23642092
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.20399320
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.17541209
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02739927
32AR_21572438_ChIP-Seq_LNCaP_Human2.00481494
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95411435
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87509932
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.68685469
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63558874
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57255537
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55509125
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.51694942
40YY1_22570637_ChIP-Seq_MALME-3M_Human1.51586419
41ZNF274_21170338_ChIP-Seq_K562_Hela1.50687504
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47368674
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.45925507
44EGR1_19032775_ChIP-ChIP_M12_Human1.43179306
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.42105814
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41528930
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.39020220
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33613367
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31929282
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.29823669
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27645632
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26306613
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.26127908
54NANOG_18555785_Chip-Seq_ESCs_Mouse1.24635199
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.24224626
56* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23824509
57* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23121739
58KDM2B_26808549_Chip-Seq_K562_Human1.22316181
59AR_25329375_ChIP-Seq_VCAP_Human1.22140543
60P300_19829295_ChIP-Seq_ESCs_Human1.21535804
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.21132476
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20947427
63AR_19668381_ChIP-Seq_PC3_Human1.20586031
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.19923374
65TAF15_26573619_Chip-Seq_HEK293_Human1.19897194
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.17491882
67RXR_22108803_ChIP-Seq_LS180_Human1.17192790
68* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.16800492
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16422257
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15431686
71STAT3_23295773_ChIP-Seq_U87_Human1.13691105
72* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.12337701
73P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12188613
74* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11041953
75TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.09612043
76* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07615269
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07201103
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06227196
79YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04928796
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03186821
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.01670260
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00547337
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00402399
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.00341514
85ER_23166858_ChIP-Seq_MCF-7_Human1.00198555
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99142324
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99056387
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98709628
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.98703218
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98600651
91CMYC_18555785_Chip-Seq_ESCs_Mouse0.98575618
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98347451
93IGF1R_20145208_ChIP-Seq_DFB_Human0.97597073
94AHR_22903824_ChIP-Seq_MCF-7_Human0.96674885
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96003486
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.95943431
97* SMAD3_21741376_ChIP-Seq_HESCs_Human0.95739932
98* TCF4_23295773_ChIP-Seq_U87_Human0.95605218
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.95143018
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.95000738
101BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94960045
102RNF2_27304074_Chip-Seq_NSC_Mouse0.94351293
103NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92689724
104TBL1_22424771_ChIP-Seq_293T_Human0.92544933
105* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91804277
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91215332
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89736786
108* GATA1_19941826_ChIP-Seq_K562_Human0.89031361
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88962035
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88931686
111CTCF_27219007_Chip-Seq_Bcells_Human0.88481512
112* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88317625
113* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88317625
114TP53_16413492_ChIP-PET_HCT116_Human0.87602552
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.87289572
116TP53_18474530_ChIP-ChIP_U2OS_Human0.87122421
117* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86963519
118EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86581144
119ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86343654
120SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86154824
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85415005
122PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.84679346
123E2F1_18555785_Chip-Seq_ESCs_Mouse0.84335559
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83582562
125BCAT_22108803_ChIP-Seq_LS180_Human0.82913906
126EGR1_23403033_ChIP-Seq_LIVER_Mouse0.82636885
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82520427
128NMYC_18555785_Chip-Seq_ESCs_Mouse0.82488052
129KLF4_18555785_Chip-Seq_ESCs_Mouse0.82470146
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.80286809
131P53_22387025_ChIP-Seq_ESCs_Mouse0.79758475
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79371512
133HNFA_21074721_ChIP-Seq_CACO-2_Human0.79353833
134ISL1_27105846_Chip-Seq_CPCs_Mouse0.79237456
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77466475
136CBP_20019798_ChIP-Seq_JUKART_Human0.77466475
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.76308772
138PHF8_20622853_ChIP-Seq_HELA_Human0.74807533
139GATA6_21074721_ChIP-Seq_CACO-2_Human0.74767956
140LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.73984805
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73348170
142SMAD4_21741376_ChIP-Seq_EPCs_Human0.73299013
143BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73084983
144CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72642881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.07713054
2MP0003880_abnormal_central_pattern4.71283383
3MP0003635_abnormal_synaptic_transmissio4.23618717
4MP0004270_analgesia4.02444395
5MP0005423_abnormal_somatic_nervous3.76483100
6MP0002063_abnormal_learning/memory/cond3.45400012
7MP0009745_abnormal_behavioral_response3.29985224
8MP0004264_abnormal_extraembryonic_tissu3.14733346
9MP0001968_abnormal_touch/_nociception3.13000706
10MP0002064_seizures3.01641365
11MP0002734_abnormal_mechanical_nocicepti2.82069691
12MP0002572_abnormal_emotion/affect_behav2.74373896
13MP0003252_abnormal_bile_duct2.72592828
14MP0009046_muscle_twitch2.65275764
15MP0004133_heterotaxia2.59694534
16MP0001486_abnormal_startle_reflex2.54085733
17MP0002735_abnormal_chemical_nociception2.42395530
18MP0002272_abnormal_nervous_system2.39890734
19MP0002928_abnormal_bile_duct2.35940427
20MP0002736_abnormal_nociception_after2.34219812
21MP0004858_abnormal_nervous_system2.27791381
22MP0009780_abnormal_chondrocyte_physiolo2.16747821
23MP0000778_abnormal_nervous_system2.12672025
24MP0001440_abnormal_grooming_behavior2.12401462
25MP0001501_abnormal_sleep_pattern2.11270808
26MP0005448_abnormal_energy_balance2.09095654
27MP0002733_abnormal_thermal_nociception2.08282728
28MP0003329_amyloid_beta_deposits2.08218933
29MP0002751_abnormal_autonomic_nervous2.02841525
30MP0005084_abnormal_gallbladder_morpholo10.5373669
31MP0001970_abnormal_pain_threshold1.93166806
32MP0002184_abnormal_innervation1.92036044
33MP0004811_abnormal_neuron_physiology1.91195829
34MP0002067_abnormal_sensory_capabilities1.87200215
35MP0008569_lethality_at_weaning1.79364001
36MP0002557_abnormal_social/conspecific_i1.74432444
37MP0001270_distended_abdomen1.73816276
38MP0002909_abnormal_adrenal_gland1.67672423
39MP0000955_abnormal_spinal_cord1.66883760
40MP0005386_behavior/neurological_phenoty1.65396116
41MP0004924_abnormal_behavior1.65396116
42MP0002822_catalepsy1.61345478
43MP0006276_abnormal_autonomic_nervous1.59968791
44MP0003879_abnormal_hair_cell1.59662096
45MP0002882_abnormal_neuron_morphology1.55771304
46MP0004885_abnormal_endolymph1.54781739
47MP0001984_abnormal_olfaction1.53822075
48MP0005551_abnormal_eye_electrophysiolog1.45908445
49MP0005379_endocrine/exocrine_gland_phen1.45641629
50MP0005646_abnormal_pituitary_gland1.43492064
51MP0002066_abnormal_motor_capabilities/c1.40135535
52MP0003633_abnormal_nervous_system1.36302861
53MP0005645_abnormal_hypothalamus_physiol1.36084163
54MP0003787_abnormal_imprinting1.33060156
55MP0005408_hypopigmentation1.24224920
56MP0003943_abnormal_hepatobiliary_system1.24077363
57MP0003121_genomic_imprinting1.22092774
58MP0005165_increased_susceptibility_to1.20093521
59MP0001502_abnormal_circadian_rhythm1.19543276
60MP0005220_abnormal_exocrine_pancreas1.18939711
61MP0002152_abnormal_brain_morphology1.16798556
62MP0003631_nervous_system_phenotype1.15797919
63MP0004142_abnormal_muscle_tone1.08049082
64MP0002229_neurodegeneration1.07052571
65MP0001529_abnormal_vocalization1.06626781
66MP0004272_abnormal_basement_membrane1.04773218
67MP0003122_maternal_imprinting0.98621632
68MP0001905_abnormal_dopamine_level0.97796424
69MP0003075_altered_response_to0.96743336
70MP0000751_myopathy0.96704790
71MP0000604_amyloidosis0.96685479
72MP0010234_abnormal_vibrissa_follicle0.93388811
73MP0003283_abnormal_digestive_organ0.93229836
74MP0002069_abnormal_eating/drinking_beha0.92912495
75MP0003634_abnormal_glial_cell0.92237473
76MP0001944_abnormal_pancreas_morphology0.91456559
77MP0001177_atelectasis0.90818309
78MP0002752_abnormal_somatic_nervous0.89798645
79MP0004510_myositis0.87754669
80MP0008961_abnormal_basal_metabolism0.84389685
81MP0003690_abnormal_glial_cell0.84278496
82MP0003632_abnormal_nervous_system0.84187029
83MP0005499_abnormal_olfactory_system0.83907196
84MP0005394_taste/olfaction_phenotype0.83907196
85MP0001958_emphysema0.83483630
86MP0008874_decreased_physiological_sensi0.83066040
87MP0004085_abnormal_heartbeat0.82365427
88MP0008872_abnormal_physiological_respon0.81904834
89MP0009764_decreased_sensitivity_to0.79624305
90MP0000470_abnormal_stomach_morphology0.79602616
91MP0004215_abnormal_myocardial_fiber0.78439945
92MP0002090_abnormal_vision0.78049122
93MP0001986_abnormal_taste_sensitivity0.78038877
94MP0000569_abnormal_digit_pigmentation0.75577009
95MP0001188_hyperpigmentation0.75391025
96MP0010386_abnormal_urinary_bladder0.75266593
97MP0002837_dystrophic_cardiac_calcinosis0.75162397
98MP0003638_abnormal_response/metabolism_0.75071657
99MP0006072_abnormal_retinal_apoptosis0.74907786
100MP0001963_abnormal_hearing_physiology0.74078755
101MP0003718_maternal_effect0.73728465
102MP0005253_abnormal_eye_physiology0.73524875
103MP0000631_abnormal_neuroendocrine_gland0.72384029
104MP0002876_abnormal_thyroid_physiology0.71107227
105MP0003137_abnormal_impulse_conducting0.70520040
106MP0005535_abnormal_body_temperature0.69898552
107MP0004145_abnormal_muscle_electrophysio0.69200852
108MP0001348_abnormal_lacrimal_gland0.69030454
109MP0003953_abnormal_hormone_level0.67782612
110MP0002693_abnormal_pancreas_physiology0.67168483
111MP0004484_altered_response_of0.66738624
112MP0003861_abnormal_nervous_system0.66682526
113MP0004742_abnormal_vestibular_system0.66137272
114MP0002078_abnormal_glucose_homeostasis0.65699777
115MP0000920_abnormal_myelination0.65574924
116MP0004233_abnormal_muscle_weight0.62082214
117MP0002638_abnormal_pupillary_reflex0.60699334
118MP0005623_abnormal_meninges_morphology0.58365418
119MP0000465_gastrointestinal_hemorrhage0.57236658
120MP0005187_abnormal_penis_morphology0.56952669
121MP0004130_abnormal_muscle_cell0.55604077
122MP0010769_abnormal_survival0.54344351
123MP0001299_abnormal_eye_distance/0.53142976
124MP0008875_abnormal_xenobiotic_pharmacok0.51296372
125MP0002089_abnormal_postnatal_growth/wei0.51167079
126MP0002082_postnatal_lethality0.51023749
127MP0010770_preweaning_lethality0.51023749
128MP0004019_abnormal_vitamin_homeostasis0.46880830
129MP0003866_abnormal_defecation0.45381285
130MP0001915_intracranial_hemorrhage0.41811837
131MP0002098_abnormal_vibrissa_morphology0.39547105

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of calcium-phosphate metabolism (HP:0100530)9.46160402
2Abnormality of dental color (HP:0011073)7.42681964
3Abnormality of renal resorption (HP:0011038)7.25857675
4Osteomalacia (HP:0002749)7.20101798
5Focal motor seizures (HP:0011153)7.12219747
6Myokymia (HP:0002411)7.06706431
7Abnormality of the dental pulp (HP:0006479)6.83783807
8Polyuria (HP:0000103)6.70982095
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.71485091
10Abnormal urine output (HP:0012590)5.71377877
11Visual hallucinations (HP:0002367)5.49991850
12Focal seizures (HP:0007359)5.34322828
13Abnormality of renal excretion (HP:0011036)4.98624085
14Epileptic encephalopathy (HP:0200134)4.76092813
15Round ear (HP:0100830)4.71463054
16Chronic bronchitis (HP:0004469)4.11457913
17Progressive cerebellar ataxia (HP:0002073)4.08783067
18Supranuclear gaze palsy (HP:0000605)4.07722204
19Febrile seizures (HP:0002373)4.06406790
20Volvulus (HP:0002580)3.86885683
21Atonic seizures (HP:0010819)3.74781476
22Mutism (HP:0002300)3.72792013
23Action tremor (HP:0002345)3.71434813
24Absence seizures (HP:0002121)3.64677912
25Generalized tonic-clonic seizures (HP:0002069)3.59037162
26Abnormality of midbrain morphology (HP:0002418)3.56965753
27Molar tooth sign on MRI (HP:0002419)3.56965753
28Nephrocalcinosis (HP:0000121)3.53210693
29Ankle clonus (HP:0011448)3.52593071
30Poor eye contact (HP:0000817)3.46290511
31Broad-based gait (HP:0002136)3.44194862
32Dialeptic seizures (HP:0011146)3.35951930
33Lip pit (HP:0100267)3.31609790
34Papilledema (HP:0001085)3.30967655
35Autoimmune thrombocytopenia (HP:0001973)3.28157016
36IgM deficiency (HP:0002850)3.27790048
37Depression (HP:0000716)3.25687181
38Impaired vibration sensation in the lower limbs (HP:0002166)3.25092583
39Urinary bladder sphincter dysfunction (HP:0002839)3.22414567
40Toxemia of pregnancy (HP:0100603)3.17520207
41Tachypnea (HP:0002789)3.16341323
42Neurofibrillary tangles (HP:0002185)3.13836643
43Depressed nasal tip (HP:0000437)3.11930158
44Impaired social interactions (HP:0000735)3.07757176
45Abnormal social behavior (HP:0012433)3.07757176
46Amblyopia (HP:0000646)3.07629863
47Cerebral inclusion bodies (HP:0100314)3.06415049
48Esophageal varix (HP:0002040)2.98554514
49Large earlobe (HP:0009748)2.96653027
50Dysdiadochokinesis (HP:0002075)2.91438184
51Abnormal eating behavior (HP:0100738)2.91177685
52Personality changes (HP:0000751)2.90884971
53Abnormality of the lower motor neuron (HP:0002366)2.90872708
54Genetic anticipation (HP:0003743)2.86832805
55Postural instability (HP:0002172)2.85862716
56Gaze-evoked nystagmus (HP:0000640)2.82885184
57Hyperventilation (HP:0002883)2.82842013
58Drooling (HP:0002307)2.81067817
59Excessive salivation (HP:0003781)2.81067817
60Abnormality of binocular vision (HP:0011514)2.75772232
61Diplopia (HP:0000651)2.75772232
62Anxiety (HP:0000739)2.74709706
63Truncal ataxia (HP:0002078)2.74077054
64Hypoparathyroidism (HP:0000829)2.73607861
65Dysmetria (HP:0001310)2.73553734
66Megalencephaly (HP:0001355)2.73397585
67Hyperphosphaturia (HP:0003109)2.73218053
68Rhinitis (HP:0012384)2.69870655
69Abnormality of the corticospinal tract (HP:0002492)2.69508932
70Urinary urgency (HP:0000012)2.66539420
71Hemiparesis (HP:0001269)2.65899091
72Amyotrophic lateral sclerosis (HP:0007354)2.64521443
73Abnormal respiratory motile cilium physiology (HP:0012261)2.63869069
74Spastic gait (HP:0002064)2.63267811
75Thick eyebrow (HP:0000574)2.62958222
76Torticollis (HP:0000473)2.61841286
77Lipoatrophy (HP:0100578)2.61646176
78Sparse lateral eyebrow (HP:0005338)2.60878962
79Bradykinesia (HP:0002067)2.58254339
80Stereotypic behavior (HP:0000733)2.55480510
81Epileptiform EEG discharges (HP:0011182)2.54398883
82Intention tremor (HP:0002080)2.51759656
83Nephronophthisis (HP:0000090)2.50484574
84Hemiplegia (HP:0002301)2.50071629
85Termporal pattern (HP:0011008)2.48963412
86Insidious onset (HP:0003587)2.48963412
87Focal dystonia (HP:0004373)2.48861805
88Akinesia (HP:0002304)2.46067927
89EEG with generalized epileptiform discharges (HP:0011198)2.45395491
90Obstructive sleep apnea (HP:0002870)2.43192283
91Impaired smooth pursuit (HP:0007772)2.42262659
92Aplasia involving bones of the extremities (HP:0009825)2.40098093
93Aplasia involving bones of the upper limbs (HP:0009823)2.40098093
94Aplasia of the phalanges of the hand (HP:0009802)2.40098093
95Intestinal fistula (HP:0100819)2.39265508
96Polyphagia (HP:0002591)2.38377637
97Hypsarrhythmia (HP:0002521)2.36648087
98Ventricular fibrillation (HP:0001663)2.34472184
99Abnormal urine phosphate concentration (HP:0012599)2.29173502
100Lower limb muscle weakness (HP:0007340)2.28997132
101Hypercalciuria (HP:0002150)2.25766841
102Panhypogammaglobulinemia (HP:0003139)2.24534613
103Apathy (HP:0000741)2.22124944
104Insomnia (HP:0100785)2.20145957
105Fetal akinesia sequence (HP:0001989)2.19675313
106Craniofacial dystonia (HP:0012179)2.19643384
107Agitation (HP:0000713)2.18871908
108Progressive inability to walk (HP:0002505)2.18695290
109Nephropathy (HP:0000112)2.17941470
110Sudden cardiac death (HP:0001645)2.17387735
111Limb dystonia (HP:0002451)2.16493074
112Absent speech (HP:0001344)2.15262584
113Hepatitis (HP:0012115)2.14642637
114Inappropriate behavior (HP:0000719)2.14220165
115Striae distensae (HP:0001065)2.14012903
116Impaired vibratory sensation (HP:0002495)2.13006157
117Chorioretinal coloboma (HP:0000567)2.11470590
118Inability to walk (HP:0002540)2.10213595
119Abnormality of ocular smooth pursuit (HP:0000617)2.08049620
120Decreased muscle mass (HP:0003199)2.07956085
121Short 5th finger (HP:0009237)2.04857338
122Pointed chin (HP:0000307)2.02920045
123Ureteral stenosis (HP:0000071)2.02444270
124Generalized myoclonic seizures (HP:0002123)2.01798227
125Overgrowth (HP:0001548)10.9336422
126Amelogenesis imperfecta (HP:0000705)10.3266231
127Prominent supraorbital ridges (HP:0000336)1.99915217
128Scanning speech (HP:0002168)1.99701701
129Rapidly progressive (HP:0003678)1.97660745
130Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.97558813
131Ankyloglossia (HP:0010296)1.96627022
132Central scotoma (HP:0000603)1.96514757
133Dilated cardiomyopathy (HP:0001644)1.96114534
134Diminished motivation (HP:0000745)1.93819440
135Hypoplasia of the brainstem (HP:0002365)1.92815979
136Aplasia/Hypoplasia of the brainstem (HP:0007362)1.92815979
137Neuronal loss in central nervous system (HP:0002529)1.92528246
138Status epilepticus (HP:0002133)1.92349764
139Bundle branch block (HP:0011710)1.89383117
140Annular pancreas (HP:0001734)1.89354811
141Dyschromatopsia (HP:0007641)1.86990700
142Periauricular skin pits (HP:0100277)1.86672956
143Preauricular pit (HP:0004467)1.86672956
144Abnormal EKG (HP:0003115)1.86562213
145Lower limb amyotrophy (HP:0007210)1.85849520
146Incomplete penetrance (HP:0003829)1.85424881
147Lower limb asymmetry (HP:0100559)1.84061032
148Abnormality of salivation (HP:0100755)1.83178331
149Ureteral obstruction (HP:0006000)1.82717745
150Agammaglobulinemia (HP:0004432)1.82694101
151Abnormality of urine glucose concentration (HP:0011016)1.82100603
152Glycosuria (HP:0003076)1.82100603
153Colitis (HP:0002583)1.81110897
154Intellectual disability, profound (HP:0002187)1.80450371
155Rigidity (HP:0002063)1.79367549
156Delusions (HP:0000746)1.77578457
157Gingival overgrowth (HP:0000212)1.76962532
158Abnormality of the fingertips (HP:0001211)1.76795266
159Abnormality of the renal medulla (HP:0100957)1.73841235
160Recurrent otitis media (HP:0000403)1.73049786
161Delayed eruption of teeth (HP:0000684)1.70886721
162Petechiae (HP:0000967)1.69616631
163Mask-like facies (HP:0000298)1.66880129
164Open mouth (HP:0000194)1.65674507
165Villous atrophy (HP:0011473)1.62581286
166Abnormality of small intestinal villus morphology (HP:0011472)1.62581286
167Abnormality of transition element cation homeostasis (HP:0011030)1.61393428
168Renal tubular dysfunction (HP:0000124)1.55934704
169Preauricular skin tag (HP:0000384)1.52227482

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.73643713
2MARK14.66100592
3MAP4K14.36721617
4EPHA44.33536606
5MAP3K93.87507889
6BLK3.31787583
7STK33.05633583
8MINK12.89902445
9MAP3K42.83796217
10PAK62.45629569
11DAPK22.42914554
12MAP2K72.31767780
13NTRK22.12761140
14PRKD32.07951471
15KSR22.07462754
16CAMKK11.80981264
17NTRK11.73901625
18KSR11.72856739
19SIK21.71911272
20MAP2K41.66545009
21PHKG21.61233310
22PHKG11.61233310
23CDK51.57983178
24MAP3K121.56573326
25MAPK131.55413124
26LATS21.47240345
27DAPK11.45279561
28TNIK1.40185322
29CDK191.38234664
30PLK21.35040176
31STK381.35023616
32FES1.28919890
33CASK1.28734794
34PRKCG1.25739751
35GRK51.25493976
36PRPF4B1.23623007
37TAOK11.06935930
38RIPK41.06812240
39MAP3K21.05809640
40TYRO31.01204645
41UHMK10.96980575
42HIPK20.93854508
43DYRK1A0.93548980
44MAP3K130.92343736
45CDK180.91564851
46CDK150.91342421
47CAMK2A0.90371370
48PAK30.89537667
49LMTK20.87091991
50ARAF0.86630891
51CAMK10.86285886
52CDK140.86234033
53STK110.85825983
54MAP4K20.84435992
55PNCK0.83678130
56RET0.82821685
57SGK4940.81789123
58SGK2230.81789123
59CCNB10.81667736
60CDK11A0.80682484
61MARK20.78431873
62INSRR0.77363127
63ALK0.76356362
64PRKCH0.75710996
65CSNK1G20.72839593
66SGK20.71864205
67RAF10.69897079
68ROCK20.68863289
69CAMK2B0.66929094
70SGK10.66790235
71PINK10.66605255
72SGK30.64707616
73WNK30.64338065
74PRKCZ0.63599158
75SRC0.63137799
76FGFR10.63077548
77PRKAA10.62428903
78ERBB30.61673362
79MAP3K60.61658237
80PDK10.59974265
81SYK0.55884718
82PTK2B0.55183123
83FER0.55025683
84OXSR10.54652432
85MAPK120.54379148
86SCYL20.53998579
87PDPK10.50899548
88DYRK20.49554416
89MAP3K70.49227572
90PRKACG0.46728278
91RPS6KA20.46529118
92RPS6KA30.45447926
93PRKCQ0.45134414
94MAP2K60.45125872
95PKN10.44225456
96CDC42BPA0.44185666
97NEK10.44135111
98PRKACA0.44025207
99PRKCE0.43558450
100FYN0.43139656
101CAMKK20.43124269
102ROCK10.40401245
103PRKACB0.39160580
104NME10.37720744
105DAPK30.37206628
106CAMK1G0.37000100
107MAP3K10.35564701
108CAMK2D0.35062165
109FGR0.34121578
110PRKCA0.33939607
111MAPK100.33423634
112CAMK40.32950360
113PRKCB0.32175622
114CAMK2G0.32087893
115TAOK20.31877819
116BMPR20.31494777
117MAP2K10.30969895
118RIPK10.30677356
119NEK60.29980913
120GSK3B0.29140136
121GRK70.28577220
122OBSCN0.27980708
123CSNK1A10.25921946
124MUSK0.25297696
125MAPKAPK50.24441308
126ABL10.24066773
127MAPK140.22503417
128MAPK90.18808136
129PRKDC0.18732358
130MAPK150.16683002
131TIE10.16517064
132SRPK10.16230227
133PRKCD0.15379591
134GRK10.12820837
135CDK10.11344647
136ADRBK20.09949250
137ERBB20.08985182
138CSNK1D0.08657281
139EPHA30.08348996

Predicted pathways (KEGG)

RankGene SetZ-score
1Tuberculosis_Homo sapiens_hsa051526.08166777
2Nicotine addiction_Homo sapiens_hsa050333.59053360
3Synaptic vesicle cycle_Homo sapiens_hsa047213.27618575
4Sulfur relay system_Homo sapiens_hsa041223.04479445
5Olfactory transduction_Homo sapiens_hsa047402.73262557
6Circadian entrainment_Homo sapiens_hsa047132.70113333
7GABAergic synapse_Homo sapiens_hsa047272.64970685
8Long-term potentiation_Homo sapiens_hsa047202.63110941
9Glutamatergic synapse_Homo sapiens_hsa047242.61681721
10Sulfur metabolism_Homo sapiens_hsa009202.55206941
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53298974
12Morphine addiction_Homo sapiens_hsa050322.42376134
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36592149
14Amphetamine addiction_Homo sapiens_hsa050312.30701350
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.27924143
16Dopaminergic synapse_Homo sapiens_hsa047282.10224299
17Linoleic acid metabolism_Homo sapiens_hsa005912.09023847
18Salivary secretion_Homo sapiens_hsa049702.05598735
19Phototransduction_Homo sapiens_hsa047442.01593663
20Cholinergic synapse_Homo sapiens_hsa047251.98711924
21Insulin secretion_Homo sapiens_hsa049111.97551893
22Gastric acid secretion_Homo sapiens_hsa049711.87432810
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83181470
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65881699
25Taste transduction_Homo sapiens_hsa047421.65631398
26Oxytocin signaling pathway_Homo sapiens_hsa049211.63257390
27Long-term depression_Homo sapiens_hsa047301.58456622
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55238303
29Renin secretion_Homo sapiens_hsa049241.54461547
30Serotonergic synapse_Homo sapiens_hsa047261.53425620
31Cocaine addiction_Homo sapiens_hsa050301.53219019
32Calcium signaling pathway_Homo sapiens_hsa040201.48974432
33Fat digestion and absorption_Homo sapiens_hsa049751.44173008
34GnRH signaling pathway_Homo sapiens_hsa049121.43793188
35Axon guidance_Homo sapiens_hsa043601.39976304
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39195661
37Gap junction_Homo sapiens_hsa045401.36017815
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31171576
39Type II diabetes mellitus_Homo sapiens_hsa049301.28846386
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.28090789
41cAMP signaling pathway_Homo sapiens_hsa040241.26930120
42Glioma_Homo sapiens_hsa052141.25574068
43Estrogen signaling pathway_Homo sapiens_hsa049151.23498518
44Ether lipid metabolism_Homo sapiens_hsa005651.21016867
45ErbB signaling pathway_Homo sapiens_hsa040121.16182642
46Melanogenesis_Homo sapiens_hsa049161.06830936
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04319147
48Collecting duct acid secretion_Homo sapiens_hsa049661.03491926
49Nitrogen metabolism_Homo sapiens_hsa009101.03351983
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03166221
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02937925
52cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01530229
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00904600
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90331710
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85517153
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.85474459
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.84572008
58Platelet activation_Homo sapiens_hsa046110.84119991
59Oocyte meiosis_Homo sapiens_hsa041140.84020381
60Arachidonic acid metabolism_Homo sapiens_hsa005900.79225487
61Dorso-ventral axis formation_Homo sapiens_hsa043200.78041553
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.77413836
63Choline metabolism in cancer_Homo sapiens_hsa052310.77066062
64Cardiac muscle contraction_Homo sapiens_hsa042600.76736120
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76231928
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72879662
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72394257
68MAPK signaling pathway_Homo sapiens_hsa040100.72102765
69Dilated cardiomyopathy_Homo sapiens_hsa054140.71389971
70Pancreatic secretion_Homo sapiens_hsa049720.70016542
71VEGF signaling pathway_Homo sapiens_hsa043700.69529572
72Thyroid hormone synthesis_Homo sapiens_hsa049180.68104068
73Ras signaling pathway_Homo sapiens_hsa040140.67724403
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66901334
75Vibrio cholerae infection_Homo sapiens_hsa051100.65799269
76Endometrial cancer_Homo sapiens_hsa052130.64976176
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60821704
78mTOR signaling pathway_Homo sapiens_hsa041500.59845444
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.58141528
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57960096
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57932513
82Glucagon signaling pathway_Homo sapiens_hsa049220.57806327
83Rap1 signaling pathway_Homo sapiens_hsa040150.55530137
84Circadian rhythm_Homo sapiens_hsa047100.54049608
85Bile secretion_Homo sapiens_hsa049760.52334109
86Endocytosis_Homo sapiens_hsa041440.51740879
87Pyruvate metabolism_Homo sapiens_hsa006200.51266312
88Wnt signaling pathway_Homo sapiens_hsa043100.50680248
89Renal cell carcinoma_Homo sapiens_hsa052110.50397970
90Insulin signaling pathway_Homo sapiens_hsa049100.49145268
91Prion diseases_Homo sapiens_hsa050200.47485581
92Alcoholism_Homo sapiens_hsa050340.45105376
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43964992
94Non-small cell lung cancer_Homo sapiens_hsa052230.43714484
95Colorectal cancer_Homo sapiens_hsa052100.43608968
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43396838
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42659628
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42200919
99Inositol phosphate metabolism_Homo sapiens_hsa005620.39993499
100Rheumatoid arthritis_Homo sapiens_hsa053230.39688047
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37703704
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37317682
103Chemokine signaling pathway_Homo sapiens_hsa040620.36429296
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36217287
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.36133844
106Type I diabetes mellitus_Homo sapiens_hsa049400.33994450
107Ovarian steroidogenesis_Homo sapiens_hsa049130.31652009
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30437772
109Parkinsons disease_Homo sapiens_hsa050120.29375899
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.28995267
111ECM-receptor interaction_Homo sapiens_hsa045120.27119769
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25598743
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25030169
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.24259160
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24030370
116Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23994404
117RNA degradation_Homo sapiens_hsa030180.23254688
118Oxidative phosphorylation_Homo sapiens_hsa001900.19587787
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.14428520
120Hedgehog signaling pathway_Homo sapiens_hsa043400.13267192
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.11847017
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.10336152
123Phagosome_Homo sapiens_hsa041450.07609416
124Purine metabolism_Homo sapiens_hsa002300.06672596
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04500715
126Vitamin B6 metabolism_Homo sapiens_hsa007500.00570242
127Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400-0.0383669
128Steroid hormone biosynthesis_Homo sapiens_hsa00140-0.0116923
129African trypanosomiasis_Homo sapiens_hsa05143-0.0074904

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