LRCOL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1kynurenine metabolic process (GO:0070189)8.93242837
2single fertilization (GO:0007338)8.32657568
3regulation of chronic inflammatory response (GO:0002676)8.13548884
4drug catabolic process (GO:0042737)8.12530317
5epoxygenase P450 pathway (GO:0019373)8.05159875
6omega-hydroxylase P450 pathway (GO:0097267)8.01990779
7glyoxylate metabolic process (GO:0046487)7.90973987
8complement activation, alternative pathway (GO:0006957)7.84808797
9exogenous drug catabolic process (GO:0042738)7.64645285
10indole-containing compound catabolic process (GO:0042436)7.62835133
11indolalkylamine catabolic process (GO:0046218)7.62835133
12tryptophan catabolic process (GO:0006569)7.62835133
13regulation of fibrinolysis (GO:0051917)7.40254335
14surfactant homeostasis (GO:0043129)7.24786832
15regulation of protein activation cascade (GO:2000257)7.19390155
16heterotypic cell-cell adhesion (GO:0034113)6.93765090
17L-phenylalanine catabolic process (GO:0006559)6.82148325
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.82148325
19regulation of complement activation (GO:0030449)6.81832425
20ethanol oxidation (GO:0006069)6.74170403
21positive regulation of type 2 immune response (GO:0002830)6.61379674
22tryptophan metabolic process (GO:0006568)6.49948582
23negative regulation of fibrinolysis (GO:0051918)6.39613706
24serine family amino acid catabolic process (GO:0009071)6.30748145
25urea metabolic process (GO:0019627)6.20620178
26L-phenylalanine metabolic process (GO:0006558)6.11766970
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.11766970
28drug metabolic process (GO:0017144)6.01973685
29oxidative demethylation (GO:0070989)5.87360785
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.85575190
31negative regulation of interleukin-10 production (GO:0032693)5.80559870
32blood coagulation, intrinsic pathway (GO:0007597)5.78945345
33fibrinolysis (GO:0042730)5.71814543
34imidazole-containing compound metabolic process (GO:0052803)5.69322634
35chemical homeostasis within a tissue (GO:0048875)5.62997478
36ethanol metabolic process (GO:0006067)5.59142834
37nitrogen cycle metabolic process (GO:0071941)5.55975307
38phenylpropanoid metabolic process (GO:0009698)5.54285365
39fertilization (GO:0009566)5.48986774
40regulation of triglyceride catabolic process (GO:0010896)5.43035993
41glycine metabolic process (GO:0006544)5.41819947
42regulation of plasminogen activation (GO:0010755)5.39505254
43urea cycle (GO:0000050)5.39017229
44opsonization (GO:0008228)5.30676754
45negative regulation of cholesterol transport (GO:0032375)5.23847272
46negative regulation of sterol transport (GO:0032372)5.23847272
47negative regulation of interleukin-8 production (GO:0032717)5.14322910
48protein activation cascade (GO:0072376)5.12051700
49bile acid biosynthetic process (GO:0006699)4.99939428
50complement activation (GO:0006956)4.99555591
51indolalkylamine metabolic process (GO:0006586)4.95603151
52aromatic amino acid family catabolic process (GO:0009074)4.94161793
53negative regulation of protein autophosphorylation (GO:0031953)4.93946468
54cellular biogenic amine catabolic process (GO:0042402)4.93929170
55amine catabolic process (GO:0009310)4.93929170
56cellular response to thyroid hormone stimulus (GO:0097067)4.90321688
57complement activation, classical pathway (GO:0006958)4.82021141
58cellular glucuronidation (GO:0052695)4.76949477
59acute-phase response (GO:0006953)4.74347360
60alkaloid metabolic process (GO:0009820)4.72846066
61positive regulation of triglyceride lipase activity (GO:0061365)4.70132371
62positive regulation of lipoprotein lipase activity (GO:0051006)4.70132371
63cellular anion homeostasis (GO:0030002)4.67314547
64negative regulation of hemostasis (GO:1900047)4.64624749
65negative regulation of blood coagulation (GO:0030195)4.64624749
66peptide catabolic process (GO:0043171)4.57215729
67negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.51574189
68glutamate metabolic process (GO:0006536)4.51212229
69transepithelial transport (GO:0070633)4.49061337
70glucuronate metabolic process (GO:0019585)4.47645891
71uronic acid metabolic process (GO:0006063)4.47645891
72bile acid metabolic process (GO:0008206)4.40759749
73negative regulation of T cell apoptotic process (GO:0070233)4.39281390
74coenzyme catabolic process (GO:0009109)4.38302817
75S-adenosylmethionine metabolic process (GO:0046500)4.33940198
76protein-lipid complex remodeling (GO:0034368)4.31104750
77macromolecular complex remodeling (GO:0034367)4.31104750
78plasma lipoprotein particle remodeling (GO:0034369)4.31104750
79regulation of humoral immune response (GO:0002920)4.27581577
80triglyceride homeostasis (GO:0070328)4.26253654
81acylglycerol homeostasis (GO:0055090)4.26253654
82alpha-amino acid catabolic process (GO:1901606)4.25776254
83negative regulation of protein activation cascade (GO:2000258)4.25610766
84aromatic amino acid family metabolic process (GO:0009072)4.21510141
85negative regulation of wound healing (GO:0061045)4.21265088
86negative regulation of coagulation (GO:0050819)4.20084428
87high-density lipoprotein particle remodeling (GO:0034375)4.17010943
88serine family amino acid metabolic process (GO:0009069)4.16813248
89tyrosine metabolic process (GO:0006570)4.16632264
90phospholipid efflux (GO:0033700)4.15313561
91epithelial cell morphogenesis (GO:0003382)4.12522836
92benzene-containing compound metabolic process (GO:0042537)4.08870220
93cellular ketone body metabolic process (GO:0046950)4.06410900
94cytolysis (GO:0019835)4.05519452
95arginine metabolic process (GO:0006525)4.03625490
96heme transport (GO:0015886)4.01511396
97phosphate ion homeostasis (GO:0055062)3.95084481
98trivalent inorganic anion homeostasis (GO:0072506)3.95084481
99serine family amino acid biosynthetic process (GO:0009070)3.93058302
100microglial cell activation (GO:0001774)3.92576311
101cholesterol efflux (GO:0033344)3.91363326
102negative regulation of lipase activity (GO:0060192)3.91201774
103regulation of MHC class I biosynthetic process (GO:0045343)3.85780957
104regulation of cholesterol esterification (GO:0010872)3.77608644
105bile acid and bile salt transport (GO:0015721)3.74936095
106glutamine family amino acid catabolic process (GO:0009065)3.72068812
107cellular amino acid catabolic process (GO:0009063)3.70883725
108negative regulation of complement activation (GO:0045916)3.65671787
109acute inflammatory response (GO:0002526)3.64592054
110positive regulation of blood coagulation (GO:0030194)3.63280727
111positive regulation of hemostasis (GO:1900048)3.63280727
112negative regulation of endopeptidase activity (GO:0010951)3.61260313
113flavonoid metabolic process (GO:0009812)3.58640142
114peptidyl-glutamic acid modification (GO:0018200)3.57034867
115cofactor catabolic process (GO:0051187)3.55491885
116ketone body metabolic process (GO:1902224)3.53574882
117positive regulation of cellular amide metabolic process (GO:0034250)3.52630029
118response to thyroid hormone (GO:0097066)3.51607642
119negative regulation of peptidase activity (GO:0010466)3.47752642
120lung-associated mesenchyme development (GO:0060484)3.46537653
121plasma lipoprotein particle clearance (GO:0034381)3.44695319
122disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.43047109
123killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.43047109
124N-acetylneuraminate metabolic process (GO:0006054)3.42144019
125positive regulation of fatty acid biosynthetic process (GO:0045723)3.41462974
126regulation of retinoic acid receptor signaling pathway (GO:0048385)3.39266334
127aldehyde catabolic process (GO:0046185)3.36492959
128regulation of bile acid biosynthetic process (GO:0070857)3.36083725
129defense response to bacterium (GO:0042742)3.30990131
130positive regulation of cell-cell adhesion (GO:0022409)3.30785873
131poly(A)+ mRNA export from nucleus (GO:0016973)3.27093283
132L-fucose catabolic process (GO:0042355)3.26831938
133fucose catabolic process (GO:0019317)3.26831938
134L-fucose metabolic process (GO:0042354)3.26831938
135cysteine metabolic process (GO:0006534)3.24542472
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.21189547
137indole-containing compound metabolic process (GO:0042430)3.14667513
138sulfur amino acid catabolic process (GO:0000098)3.12964398
139viral transcription (GO:0019083)3.03795721
140seminiferous tubule development (GO:0072520)22.2862966
141translational termination (GO:0006415)2.99881346
142regulation of type 2 immune response (GO:0002828)2.95397654
143macrophage activation (GO:0042116)2.93322271
144T cell mediated immunity (GO:0002456)2.91837148
145phagocytosis, engulfment (GO:0006911)2.88798290
146positive regulation of monocyte chemotaxis (GO:0090026)2.86847384
147glial cell proliferation (GO:0014009)2.83915071
148ribosomal small subunit biogenesis (GO:0042274)2.79820600
149negative regulation of interleukin-6 production (GO:0032715)2.78156523
150protein carboxylation (GO:0018214)2.78038107
151peptidyl-glutamic acid carboxylation (GO:0017187)2.78038107
152response to bacterium (GO:0009617)2.77230066
153piRNA metabolic process (GO:0034587)2.75814288
154negative regulation of lymphocyte apoptotic process (GO:0070229)2.71832960
155lung lobe morphogenesis (GO:0060463)2.70401688
156regulation of T cell apoptotic process (GO:0070232)2.70034629
157regulation of macrophage activation (GO:0043030)2.69771801
158SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67740098
159ribosomal small subunit assembly (GO:0000028)2.67418946
160negative regulation of smooth muscle cell migration (GO:0014912)2.66069441
161positive regulation of interleukin-12 production (GO:0032735)2.65270938
162AMP metabolic process (GO:0046033)2.65057631
163cotranslational protein targeting to membrane (GO:0006613)2.63740195
164negative regulation of proteolysis (GO:0045861)2.62330370
165protein targeting to ER (GO:0045047)2.61628473
166anterior/posterior axis specification, embryo (GO:0008595)2.54079655
167otic vesicle formation (GO:0030916)2.52469440
168regulation of clathrin-mediated endocytosis (GO:2000369)2.52024969
169negative regulation of protein processing (GO:0010955)2.50353578
170negative regulation of protein maturation (GO:1903318)2.50353578
171columnar/cuboidal epithelial cell development (GO:0002066)2.47352784
172regulation of beta-amyloid formation (GO:1902003)2.47001903
173pantothenate metabolic process (GO:0015939)2.45747183
174negative regulation of transcription by competitive promoter binding (GO:0010944)2.45587661
175establishment of protein localization to endoplasmic reticulum (GO:0072599)2.44037120
176protein localization to endoplasmic reticulum (GO:0070972)2.41988410
177leukocyte mediated cytotoxicity (GO:0001909)2.41580934
178phospholipid homeostasis (GO:0055091)2.39164791
179DNA unwinding involved in DNA replication (GO:0006268)2.38880284
180DNA topological change (GO:0006265)2.38786875
181translational elongation (GO:0006414)2.37885734
182response to vitamin A (GO:0033189)2.36240734
183reverse cholesterol transport (GO:0043691)2.36022474
184epithelial cell differentiation involved in prostate gland development (GO:0060742)2.35463260
185production of molecular mediator involved in inflammatory response (GO:0002532)13.9002536
186regulation of T cell tolerance induction (GO:0002664)13.0556909
187positive regulation of tolerance induction (GO:0002645)11.3961871
188sperm capacitation (GO:0048240)10.4340480
189regulation of tolerance induction (GO:0002643)10.1139450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human7.43691335
2E2F7_22180533_ChIP-Seq_HELA_Human6.60178318
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.40580163
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.12233331
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.50617448
6ZNF263_19887448_ChIP-Seq_K562_Human4.39649863
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.12246368
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.07853333
9IKZF1_21737484_ChIP-ChIP_HCT116_Human3.76928405
10FLI1_27457419_Chip-Seq_LIVER_Mouse3.65254096
11ESR1_21235772_ChIP-Seq_MCF-7_Human3.22968841
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.02238004
13AR_21572438_ChIP-Seq_LNCaP_Human2.55380723
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45477395
15GATA3_21867929_ChIP-Seq_TH1_Mouse2.43863157
16PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse2.26113401
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.25823220
18FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse2.23311375
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.23273591
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.20450408
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14338487
22EGR1_23403033_ChIP-Seq_LIVER_Mouse2.08480893
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06852766
24AR_21909140_ChIP-Seq_LNCAP_Human2.06611668
25STAT1_17558387_ChIP-Seq_HELA_Human2.05566982
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.03407828
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.94328526
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91112226
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.91051723
30SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.89848979
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.89178239
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87578652
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.79688453
34SOX2_22085726_ChIP-Seq_NPCs_Mouse1.79257219
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.77319099
36CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68562451
37FLI1_21867929_ChIP-Seq_CD8_Mouse1.68284249
38GATA1_22025678_ChIP-Seq_K562_Human1.66779117
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.64599341
40SMAD1_18555785_Chip-Seq_ESCs_Mouse1.63643334
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.59126629
42KAP1_22055183_ChIP-Seq_ESCs_Mouse1.59045313
43CTCF_27219007_Chip-Seq_Bcells_Human1.58368255
44NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.57781117
45ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55485545
46LXR_22292898_ChIP-Seq_THP-1_Human1.51679089
47REST_19997604_ChIP-ChIP_NEURONS_Mouse1.49743866
48NANOG_18692474_ChIP-Seq_MEFs_Mouse1.48341572
49HNF4A_19822575_ChIP-Seq_HepG2_Human1.47633732
50SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.46541189
51CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46342406
52RAD21_21589869_ChIP-Seq_MESCs_Mouse1.46173040
53TET1_21451524_ChIP-Seq_MESCs_Mouse1.45595853
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.44578324
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.44060637
56HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.42455311
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38706087
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38485223
59RARB_24833708_ChIP-Seq_LIVER_Mouse1.34704643
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30954961
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30886668
62JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.29968961
63FOXA2_19822575_ChIP-Seq_HepG2_Human1.29634600
64CTCF_20526341_ChIP-Seq_ESCs_Human1.29346436
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.28620849
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28497419
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27272640
68GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.24684119
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23753618
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.22430002
71E2F1_20622854_ChIP-Seq_HELA_Human1.22175927
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21914297
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.21311249
74SMC4_20622854_ChIP-Seq_HELA_Human1.20825183
75BCAT_22108803_ChIP-Seq_LS180_Human1.20591715
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.20040857
77SALL4_22934838_ChIP-ChIP_CD34+_Human1.19782432
78GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.19527309
79ERA_21632823_ChIP-Seq_H3396_Human1.19380489
80RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19087952
81ESRRB_18555785_Chip-Seq_ESCs_Mouse1.18820558
82ETS1_21867929_ChIP-Seq_TH2_Mouse1.18531047
83RAC3_21632823_ChIP-Seq_H3396_Human1.18230332
84LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17608591
85MYC_27129775_Chip-Seq_CORNEA_Mouse1.17561754
86MYC_19829295_ChIP-Seq_ESCs_Human1.15968501
87NANOG_18692474_ChIP-Seq_MESCs_Mouse1.15382052
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.11895006
89SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11852884
90IGF1R_20145208_ChIP-Seq_DFB_Human1.11052743
91CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10657799
92XRN2_22483619_ChIP-Seq_HELA_Human1.09946984
93CLOCK_20551151_ChIP-Seq_293T_Human1.09349005
94RARA_24833708_ChIP-Seq_LIVER_Mouse1.08119668
95ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07891137
96MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06678638
97VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.06596368
98SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06413282
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.05834522
100BCL6_27268052_Chip-Seq_Bcells_Human1.05317577
101FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04627458
102SOX2_20726797_ChIP-Seq_SW620_Human1.04251397
103RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04233515
104CTCF_21964334_Chip-Seq_Bcells_Human1.03841914
105FOXH1_21741376_ChIP-Seq_ESCs_Human1.03830602
106P300_27268052_Chip-Seq_Bcells_Human1.03441794
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02242759
108RNF2_27304074_Chip-Seq_NSC_Mouse1.02192476
109PHF8_20622854_ChIP-Seq_HELA_Human1.01331560
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.00135089
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.00012731
112OCT4_20526341_ChIP-Seq_ESCs_Human0.99808559
113GATA3_21867929_ChIP-Seq_CD8_Mouse0.99126466
114GBX2_23144817_ChIP-Seq_PC3_Human0.99015441
115HTT_18923047_ChIP-ChIP_STHdh_Human0.98895432
116EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98691041
117DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96653006
118PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96543041
119SPI1_20517297_ChIP-Seq_HL60_Human0.96532138
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95742318
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95418613
122ESET_19884257_ChIP-Seq_ESCs_Mouse0.95171738
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94706180
124PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94153042
125MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93897698
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93239645
127SOX2_21211035_ChIP-Seq_LN229_Human0.92965960
128P68_20966046_ChIP-Seq_HELA_Human0.92689289
129ERG_20517297_ChIP-Seq_VCAP_Human0.92192973
130CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90511868
131TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88944914
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88877904
133CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88679646
134P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88673739
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88383952
136ER_23166858_ChIP-Seq_MCF-7_Human0.88322852
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.87982602
138TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87795044
139BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.87580446
140OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86855122
141NANOG_20526341_ChIP-Seq_ESCs_Human0.86517173
142SOX2_18692474_ChIP-Seq_MEFs_Mouse0.85686198
143WDR5_24793694_ChIP-Seq_LNCAP_Human0.85436768
144BCOR_27268052_Chip-Seq_Bcells_Human0.85166681
145MYC_19915707_ChIP-ChIP_AK7_Human0.84428897
146HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83595626
147CTCF_21964334_ChIP-Seq_BJAB-B_Human0.82468326
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81833735
149CBP_21632823_ChIP-Seq_H3396_Human0.79810878
150ETV2_25802403_ChIP-Seq_MESCs_Mouse0.77535434
151CSB_26484114_Chip-Seq_FIBROBLAST_Human0.74928526
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74342571
153EED_16625203_ChIP-ChIP_MESCs_Mouse0.72768792
154YY1_22570637_ChIP-Seq_MALME-3M_Human0.69607888
155PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.68123170
156CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.67776362
157EZH2_27294783_Chip-Seq_ESCs_Mouse0.66827352
158GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.66665518
159AR_20517297_ChIP-Seq_VCAP_Human0.66311671
160OCT4_19829295_ChIP-Seq_ESCs_Human0.65962786
161TAF2_19829295_ChIP-Seq_ESCs_Human0.65252964
162KLF5_20875108_ChIP-Seq_MESCs_Mouse0.64379646
163NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64278436
164SA1_27219007_Chip-Seq_ERYTHROID_Human0.64273257
165SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63528396
166BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.61868305
167HNFA_21074721_ChIP-Seq_CACO-2_Human0.61090180
168EZH2_22144423_ChIP-Seq_EOC_Human0.60321476
169CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.59979628
170IRF8_22096565_ChIP-ChIP_GC-B_Human0.59416928

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.01490778
2MP0004782_abnormal_surfactant_physiolog7.01380042
3MP0008875_abnormal_xenobiotic_pharmacok5.41358512
4MP0005058_abnormal_lysosome_morphology4.73375247
5MP0004043_abnormal_pH_regulation4.47331543
6MP0003303_peritoneal_inflammation4.46123677
7MP0002138_abnormal_hepatobiliary_system3.77059805
8MP0001958_emphysema3.49674158
9MP0010234_abnormal_vibrissa_follicle3.41656987
10MP0009697_abnormal_copulation3.17791102
11MP0002254_reproductive_system_inflammat3.13954506
12MP0003868_abnormal_feces_composition2.83703612
13MP0005408_hypopigmentation2.64288888
14MP0008995_early_reproductive_senescence2.63484692
15MP0000537_abnormal_urethra_morphology2.63234257
16MP0003252_abnormal_bile_duct2.60002448
17MP0005083_abnormal_biliary_tract2.57887496
18MP0001666_abnormal_nutrient_absorption2.42892686
19MP0005410_abnormal_fertilization2.31404156
20MP0000462_abnormal_digestive_system2.17994041
21MP0003806_abnormal_nucleotide_metabolis2.17315837
22MP0003693_abnormal_embryo_hatching2.06032693
23MP0003566_abnormal_cell_adhesion1.96444626
24MP0003195_calcinosis1.93477642
25MP0003315_abnormal_perineum_morphology1.93273432
26MP0002133_abnormal_respiratory_system1.91750816
27MP0005388_respiratory_system_phenotype1.91750816
28MP0002139_abnormal_hepatobiliary_system1.91626487
29MP0001764_abnormal_homeostasis1.91179167
30MP0010368_abnormal_lymphatic_system1.91059345
31MP0000566_synostosis1.86314747
32MP0005085_abnormal_gallbladder_physiolo1.74830937
33MP0001177_atelectasis1.72082590
34MP0003724_increased_susceptibility_to1.70650666
35MP0002249_abnormal_larynx_morphology1.68383568
36MP0010678_abnormal_skin_adnexa1.60525927
37MP0003300_gastrointestinal_ulcer1.57016981
38MP0005187_abnormal_penis_morphology1.54059231
39MP0002295_abnormal_pulmonary_circulatio1.52782743
40MP0003191_abnormal_cellular_cholesterol1.52725833
41MP0000003_abnormal_adipose_tissue1.47580270
42MP0006082_CNS_inflammation1.46683141
43MP0008057_abnormal_DNA_replication1.46312653
44MP0004019_abnormal_vitamin_homeostasis1.40134748
45MP0003786_premature_aging1.38409453
46MP0010329_abnormal_lipoprotein_level1.37069805
47MP0003329_amyloid_beta_deposits1.36690053
48MP0000609_abnormal_liver_physiology1.33872787
49MP0004885_abnormal_endolymph1.33414098
50MP0003183_abnormal_peptide_metabolism1.33305566
51MP0003136_yellow_coat_color1.21916108
52MP0001929_abnormal_gametogenesis1.19641503
53MP0001853_heart_inflammation1.16481040
54MP0002876_abnormal_thyroid_physiology1.15970210
55MP0005670_abnormal_white_adipose1.14662183
56MP0003879_abnormal_hair_cell1.12983686
57MP0005365_abnormal_bile_salt1.12154358
58MP0002160_abnormal_reproductive_system1.11891603
59MP0003698_abnormal_male_reproductive1.11741943
60MP0002089_abnormal_postnatal_growth/wei1.10963293
61MP0009053_abnormal_anal_canal1.10181091
62MP0000647_abnormal_sebaceous_gland1.09781285
63MP0003718_maternal_effect1.09642887
64MP0002396_abnormal_hematopoietic_system1.05922610
65MP0004957_abnormal_blastocyst_morpholog1.03528172
66MP0004264_abnormal_extraembryonic_tissu1.02310872
67MP0010030_abnormal_orbit_morphology1.01614241
68MP0000747_muscle_weakness1.00895148
69MP0003690_abnormal_glial_cell0.99715144
70MP0000678_abnormal_parathyroid_gland0.97225960
71MP0001984_abnormal_olfaction0.93903465
72MP0003828_pulmonary_edema0.93132572
73MP0005257_abnormal_intraocular_pressure0.91979246
74MP0002132_abnormal_respiratory_system0.91793858
75MP0009643_abnormal_urine_homeostasis0.91542747
76MP0000383_abnormal_hair_follicle0.90666294
77MP0002405_respiratory_system_inflammati0.89745968
78MP0005395_other_phenotype0.89255622
79MP0001145_abnormal_male_reproductive0.88822053
80MP0008004_abnormal_stomach_pH0.87276511
81MP0004883_abnormal_blood_vessel0.87262309
82MP0002796_impaired_skin_barrier0.86539097
83MP0002118_abnormal_lipid_homeostasis0.86441069
84MP0001986_abnormal_taste_sensitivity0.85995529
85MP0001661_extended_life_span0.85111183
86MP0006292_abnormal_olfactory_placode0.84326187
87MP0002234_abnormal_pharynx_morphology0.82409416
88MP0005171_absent_coat_pigmentation0.81208832
89MP0001727_abnormal_embryo_implantation0.81103249
90MP0002148_abnormal_hypersensitivity_rea0.79897996
91MP0005397_hematopoietic_system_phenotyp0.79609705
92MP0001545_abnormal_hematopoietic_system0.79609705
93MP0000627_abnormal_mammary_gland0.79544022
94MP0002971_abnormal_brown_adipose0.79258636
95MP0005319_abnormal_enzyme/_coenzyme0.79209669
96MP0005376_homeostasis/metabolism_phenot0.78680290
97MP0010094_abnormal_chromosome_stability0.78015471
98MP0001533_abnormal_skeleton_physiology0.77619739
99MP0003878_abnormal_ear_physiology0.75293195
100MP0005377_hearing/vestibular/ear_phenot0.75293195
101MP0001346_abnormal_lacrimal_gland0.74819554
102MP0002282_abnormal_trachea_morphology0.74729526
103MP0005584_abnormal_enzyme/coenzyme_acti0.74621811
104MP0002161_abnormal_fertility/fecundity0.74350645
105MP0000598_abnormal_liver_morphology0.73627619
106MP0005499_abnormal_olfactory_system0.72819481
107MP0005394_taste/olfaction_phenotype0.72819481
108MP0005381_digestive/alimentary_phenotyp0.71666022
109MP0004272_abnormal_basement_membrane0.71617083
110MP0005075_abnormal_melanosome_morpholog0.70971004
111MP0004130_abnormal_muscle_cell0.70676946
112MP0002210_abnormal_sex_determination0.70440207
113MP0010386_abnormal_urinary_bladder0.70214820
114MP0005332_abnormal_amino_acid0.69069707
115MP0005375_adipose_tissue_phenotype0.68440257
116MP0002168_other_aberrant_phenotype0.68308214
117MP0010352_gastrointestinal_tract_polyps0.68304132
118MP0001440_abnormal_grooming_behavior0.68131798
119MP0009642_abnormal_blood_homeostasis0.66619519
120MP0005166_decreased_susceptibility_to0.66547466
121MP0000579_abnormal_nail_morphology0.66349355
122MP0000604_amyloidosis0.65590821
123MP0003787_abnormal_imprinting0.64686788
124MP0001501_abnormal_sleep_pattern0.64552832
125MP0005023_abnormal_wound_healing0.64514803
126MP0000538_abnormal_urinary_bladder0.63439116
127MP0008874_decreased_physiological_sensi0.62707456
128MP0003448_altered_tumor_morphology0.62107810
129MP0000685_abnormal_immune_system0.61755622
130MP0009764_decreased_sensitivity_to0.61223701
131MP0009840_abnormal_foam_cell0.61053317
132MP0005248_abnormal_Harderian_gland0.60126748
133MP0008877_abnormal_DNA_methylation0.60022646
134MP0009763_increased_sensitivity_to0.59081657
135MP0004185_abnormal_adipocyte_glucose0.59011216
136MP0003453_abnormal_keratinocyte_physiol0.57998648
137MP0008872_abnormal_physiological_respon0.57039863
138MP0005535_abnormal_body_temperature0.56501485
139MP0008789_abnormal_olfactory_epithelium0.54874726
140MP0003938_abnormal_ear_development0.54542497
141MP0000049_abnormal_middle_ear0.54485836
142MP0001664_abnormal_digestion0.53149743
143MP0002233_abnormal_nose_morphology0.52674033
144MP0002102_abnormal_ear_morphology0.52324884
145MP0005334_abnormal_fat_pad0.50085715
146MP0003186_abnormal_redox_activity0.48494390
147MP0003656_abnormal_erythrocyte_physiolo0.47998018
148MP0005646_abnormal_pituitary_gland0.47313214
149MP0001756_abnormal_urination0.47233169
150MP0002090_abnormal_vision0.46529424
151MP0005167_abnormal_blood-brain_barrier0.45727914
152MP0000467_abnormal_esophagus_morphology0.45253201
153MP0005636_abnormal_mineral_homeostasis0.44853192
154MP0005409_darkened_coat_color0.41273781
155MP0002078_abnormal_glucose_homeostasis0.41157410
156MP0005647_abnormal_sex_gland0.41033149
157MP0001879_abnormal_lymphatic_vessel0.40896443
158MP0005330_cardiomyopathy0.36761675
159MP0001270_distended_abdomen0.36460094
160MP0003283_abnormal_digestive_organ0.35853639
161MP0005551_abnormal_eye_electrophysiolog0.35792201
162MP0003011_delayed_dark_adaptation0.34696997
163MP0001915_intracranial_hemorrhage0.34646995
164MP0008469_abnormal_protein_level0.33126897
165MP0001502_abnormal_circadian_rhythm0.32977760

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.34773113
2Abnormality of monocarboxylic acid metabolism (HP:0010996)9.07313862
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.87418312
4Joint hemorrhage (HP:0005261)7.20758869
5Abnormality of complement system (HP:0005339)6.99527488
6Hypobetalipoproteinemia (HP:0003563)6.87513504
7Systemic lupus erythematosus (HP:0002725)6.27580786
8Abnormality of the intrinsic pathway (HP:0010989)6.04447770
9Hyperlipoproteinemia (HP:0010980)5.95305435
10Interstitial pulmonary disease (HP:0006530)4.90274456
11Xanthomatosis (HP:0000991)4.81504415
12Gout (HP:0001997)4.81319515
13Abnormality of pyrimidine metabolism (HP:0004353)4.51753205
14Vacuolated lymphocytes (HP:0001922)4.48562590
15Reduced antithrombin III activity (HP:0001976)4.44089912
16Neurofibrillary tangles (HP:0002185)4.13344139
17Hemorrhage of the eye (HP:0011885)4.11646949
18Glomerulonephritis (HP:0000099)4.08045024
19Chronic otitis media (HP:0000389)4.02987933
20Spontaneous abortion (HP:0005268)4.02683062
21Hypolipoproteinemia (HP:0010981)3.99741515
22Stenosis of the external auditory canal (HP:0000402)3.96751886
23Intrahepatic cholestasis (HP:0001406)3.94397020
24Conjugated hyperbilirubinemia (HP:0002908)3.94280224
25Azoospermia (HP:0000027)3.87074205
26Abnormality of the common coagulation pathway (HP:0010990)3.83480455
27Abnormality of macrophages (HP:0004311)3.70366801
28Recurrent bacterial skin infections (HP:0005406)3.70023074
29Tubulointerstitial fibrosis (HP:0005576)3.65569146
30Metaphyseal cupping (HP:0003021)3.64605818
31Hypoalphalipoproteinemia (HP:0003233)3.58255132
32Hyperglycinuria (HP:0003108)3.54794735
33Abnormality of methionine metabolism (HP:0010901)3.49794262
34Ileus (HP:0002595)3.48094211
35Abnormality of the phalanges of the 2nd finger (HP:0009541)3.47302856
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.39208286
37Turricephaly (HP:0000262)3.34841915
38Hypokinesia (HP:0002375)3.30240560
39Premature skin wrinkling (HP:0100678)3.22531935
40Abnormal spermatogenesis (HP:0008669)3.16365360
41Cerebral inclusion bodies (HP:0100314)3.15781831
42Generalized aminoaciduria (HP:0002909)3.15584633
43Partial duplication of thumb phalanx (HP:0009944)3.08853513
44Pustule (HP:0200039)3.07950456
45Abnormality of cells of the erythroid lineage (HP:0012130)3.07818374
46Nephritis (HP:0000123)3.07296546
47Poor head control (HP:0002421)3.06612106
48Male infertility (HP:0003251)3.05814301
49Respiratory distress (HP:0002098)3.01425095
50Arterial tortuosity (HP:0005116)2.99102608
51Abnormality of the fovea (HP:0000493)2.98581863
52Vascular tortuosity (HP:0004948)2.93469951
53Abnormality of the labia minora (HP:0012880)2.91877190
54Abnormality of the 2nd finger (HP:0004100)2.91876808
55Recurrent abscess formation (HP:0002722)2.89252425
56Rectal prolapse (HP:0002035)2.88813296
57Abnormality of sulfur amino acid metabolism (HP:0004339)2.87534941
58Delayed CNS myelination (HP:0002188)2.85265248
59Recurrent gram-negative bacterial infections (HP:0005420)2.84508282
60Myocardial infarction (HP:0001658)2.76839974
61Polar cataract (HP:0010696)2.74664002
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.73609904
63Abnormal number of erythroid precursors (HP:0012131)2.72308163
64Atrioventricular block (HP:0001678)2.70052367
65Esophageal atresia (HP:0002032)2.69688860
66Hyperammonemia (HP:0001987)2.69567346
67Thoracic kyphosis (HP:0002942)2.65034244
68Abnormality of glycine metabolism (HP:0010895)2.64680633
69Abnormality of serine family amino acid metabolism (HP:0010894)2.64680633
70Abnormality of glutamine family amino acid metabolism (HP:0010902)2.64427091
71Increased purine levels (HP:0004368)2.64143726
72Hyperuricemia (HP:0002149)2.64143726
73Stomatitis (HP:0010280)2.62685696
74Partial duplication of the phalanx of hand (HP:0009999)2.62556701
75Aplasia involving bones of the upper limbs (HP:0009823)2.59744911
76Aplasia of the phalanges of the hand (HP:0009802)2.59744911
77Aplasia involving bones of the extremities (HP:0009825)2.59744911
78Ulnar bowing (HP:0003031)2.57035787
79Abnormality of serum amino acid levels (HP:0003112)2.55771878
80Spondylolisthesis (HP:0003302)2.55013787
81Subcapsular cataract (HP:0000523)2.54792045
82Supranuclear gaze palsy (HP:0000605)2.49631544
83Reticulocytopenia (HP:0001896)2.49390803
84Multiple enchondromatosis (HP:0005701)2.45535508
85Abnormal cartilage morphology (HP:0002763)2.45057788
86Neonatal respiratory distress (HP:0002643)2.44641175
87Facial hemangioma (HP:0000329)2.40253800
88Beaking of vertebral bodies (HP:0004568)2.37327456
89Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36448641
90Ketosis (HP:0001946)2.33826686
91Purpura (HP:0000979)2.33742670
92Thrombophlebitis (HP:0004418)2.32692675
93Complement deficiency (HP:0004431)2.31741910
94Malnutrition (HP:0004395)2.30970754
95Vascular calcification (HP:0004934)2.28911492
96Menorrhagia (HP:0000132)2.27799237
97Hyperphosphaturia (HP:0003109)2.27165336
98Rickets (HP:0002748)2.24679551
99Stomach cancer (HP:0012126)2.23922623
100Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22327293
101Abnormality of purine metabolism (HP:0004352)2.19783108
102Pulmonary embolism (HP:0002204)2.19573588
103Glycosuria (HP:0003076)2.19393166
104Abnormality of urine glucose concentration (HP:0011016)2.19393166
105Osteolytic defects of the hand bones (HP:0009699)2.18813479
106Osteolytic defects of the phalanges of the hand (HP:0009771)2.18813479
107Autoimmune thrombocytopenia (HP:0001973)2.17650753
108Chromsome breakage (HP:0040012)2.17462804
109Hepatocellular carcinoma (HP:0001402)2.14307875
110Mitral stenosis (HP:0001718)2.13703679
111Hyperglycinemia (HP:0002154)2.13370858
112Choanal stenosis (HP:0000452)2.11676809
113Fat malabsorption (HP:0002630)2.09538018
114Bronchomalacia (HP:0002780)2.08670720
115Fair hair (HP:0002286)2.08192163
116Retinal atrophy (HP:0001105)2.07511425
117Abnormal biliary tract physiology (HP:0012439)2.06996000
118Bile duct proliferation (HP:0001408)2.06996000
119Split foot (HP:0001839)2.06934304
120Hypopigmentation of the fundus (HP:0007894)2.05039886
121Abnormal urine phosphate concentration (HP:0012599)2.03695094
122Neonatal hypoglycemia (HP:0001998)2.02856552
123Hypophosphatemic rickets (HP:0004912)2.02700161
124Epidermoid cyst (HP:0200040)2.02291798
125Abnormality of nucleobase metabolism (HP:0010932)2.02149977
126Metabolic acidosis (HP:0001942)2.01309403
127Prolonged partial thromboplastin time (HP:0003645)10.0659903
128Cardiovascular calcification (HP:0011915)1.99244527
129Broad distal phalanx of finger (HP:0009836)1.99004367
130Hypercholesterolemia (HP:0003124)1.98982748
131Congenital ichthyosiform erythroderma (HP:0007431)1.96895204
132Gingival bleeding (HP:0000225)1.96387845
133Birth length less than 3rd percentile (HP:0003561)1.96361379
134Broad metatarsal (HP:0001783)1.95544328
135Neonatal onset (HP:0003623)1.94515176
136Enlarged kidneys (HP:0000105)1.93649450
137Eczematoid dermatitis (HP:0000976)1.92409550
138Prolonged neonatal jaundice (HP:0006579)1.91526523
139Dysostosis multiplex (HP:0000943)1.91366217
140Shallow orbits (HP:0000586)1.90846086
141Premature loss of primary teeth (HP:0006323)1.90094156
142Facial shape deformation (HP:0011334)1.89434233
143Potter facies (HP:0002009)1.89434233
144Abnormal rod and cone electroretinograms (HP:0008323)1.88234909
145Humeroradial synostosis (HP:0003041)1.86410413
146Synostosis involving the elbow (HP:0003938)1.86410413
147Short middle phalanx of finger (HP:0005819)1.83893432
148Abnormality of the lumbar spine (HP:0100712)1.82008155
149Abnormality of the salivary glands (HP:0010286)1.81900560
150Death in infancy (HP:0001522)1.81574988
151Dyschromatopsia (HP:0007641)1.81362270
152Abnormality of the parietal bone (HP:0002696)1.79637572
153Choroideremia (HP:0001139)1.79592721
154Osteomalacia (HP:0002749)1.79374508
155Abnormality of the thoracic spine (HP:0100711)1.79355794
156Breast hypoplasia (HP:0003187)1.76655103
157Tubular atrophy (HP:0000092)1.74139094
158Pigmentary retinal degeneration (HP:0001146)1.73486027
159Nasolacrimal duct obstruction (HP:0000579)1.70968692
160Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.70457300
161Congenital sensorineural hearing impairment (HP:0008527)1.70023066
162Widely patent fontanelles and sutures (HP:0004492)1.69664725
163Hyperbilirubinemia (HP:0002904)1.69591504
164Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69424306
165Cholelithiasis (HP:0001081)1.68869570
166Self-mutilation (HP:0000742)1.65132626
167Abnormality of iron homeostasis (HP:0011031)1.64580133
168Gangrene (HP:0100758)1.61197225
169Rib fusion (HP:0000902)1.60829590
170Blue irides (HP:0000635)1.60593038
171Lethargy (HP:0001254)1.60193948
172Bifid scrotum (HP:0000048)1.57036510
173Vomiting (HP:0002013)1.56530465
174Increased serum ferritin (HP:0003281)1.56422640
175Abnormality of fatty-acid metabolism (HP:0004359)1.56298524
176Elevated alkaline phosphatase (HP:0003155)1.55125623
177Capillary hemangiomas (HP:0005306)1.54868107
178Heart block (HP:0012722)1.53719463
179Abnormal gallbladder morphology (HP:0012437)1.53323277
180Irritability (HP:0000737)1.52685035
181Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.50843418
182Steatorrhea (HP:0002570)1.48229055
183Alkalosis (HP:0001948)1.47935021
184Intellectual disability, progressive (HP:0006887)1.46714862
185Mesangial abnormality (HP:0001966)1.45672900
186Megaloblastic anemia (HP:0001889)1.44420518
187Abnormality of the vitreous humor (HP:0004327)1.42149393
188Abnormal atrioventricular conduction (HP:0005150)1.41308239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK27.78127675
2PINK16.77193518
3FGFR25.57728930
4MARK34.75528618
5MAPK153.94823308
6MYLK3.12892192
7PIK3CG3.01865194
8LATS12.90515882
9TLK12.52415238
10LATS22.51865101
11PAK42.40134814
12BRSK22.36589861
13WEE12.33015634
14WNK42.27783195
15MAP3K92.26766709
16ACVR1B2.24297826
17EPHA22.23741613
18MAP3K32.20273372
19NEK22.05366184
20AKT32.05072762
21RPS6KA52.00117682
22TGFBR21.94832752
23MST41.86455823
24ERN11.78207196
25KSR21.77830408
26NME21.73992947
27TESK11.63293091
28TAOK31.60882089
29LRRK21.55276401
30ZAK1.52470569
31PRKD31.47766379
32BUB11.46852277
33CDK61.45710906
34DAPK21.44036365
35TRIB31.40110987
36MAP2K71.35018940
37CDK31.33445699
38DDR21.33069536
39CSNK1G31.25226294
40PDK31.22556199
41PDK41.22556199
42RAF11.22325938
43MST1R1.21682039
44TNK21.16016942
45PDPK11.14113729
46IRAK41.13081757
47MAP3K11.12862303
48PDK21.07762785
49SIK11.03553793
50FER1.03493179
51CAMKK21.03027775
52MUSK1.02442766
53TIE11.01474208
54IRAK21.00052652
55MAP3K130.98041156
56CSNK1G10.97010799
57RPS6KA40.95799663
58CSNK1A1L0.94804908
59EPHA30.93877255
60PKN20.93504732
61MOS0.90790866
62EIF2AK30.90770384
63MAP3K100.90692331
64FRK0.90473908
65STK38L0.89652243
66MET0.89131291
67PTK2B0.85641331
68EPHA40.84117951
69MAP3K60.83452896
70DYRK20.79460854
71CDC70.78193648
72PRKG20.77262732
73EPHB20.75760367
74ARAF0.74990264
75DAPK30.74021954
76BRSK10.73473368
77RPS6KB10.73423730
78FGFR10.72810038
79GRK50.71172331
80PAK10.68803698
81PRKCQ0.67009864
82MAPK120.66685968
83MATK0.65531303
84TGFBR10.65330967
85CSNK1G20.63685860
86PIK3CA0.62844483
87PRKG10.60612335
88SGK20.59751560
89KDR0.59120076
90KSR10.58727488
91CDC42BPA0.58320692
92ICK0.57928589
93WNK30.57617301
94OBSCN0.57358868
95MAPK110.55287420
96PRKCG0.54583973
97CDK140.54429618
98STK100.53918596
99PLK10.51767496
100PASK0.51318992
101GRK10.50322995
102WNK10.49834064
103CSNK1D0.48697580
104CDK190.48642161
105AKT20.48523990
106ZAP700.48486715
107FGFR30.47766322
108STK390.47414794
109NEK10.47083318
110MTOR0.46509932
111DYRK30.45950446
112STK160.45452373
113BLK0.44068434
114RPS6KA10.43883237
115ILK0.43380252
116TSSK60.43293116
117PDK10.42814648
118EEF2K0.41860081
119AURKB0.41730579
120DYRK1B0.40765807
121GRK60.40559175
122MAP3K20.39787580
123RPS6KB20.39355512
124CSF1R0.39254738
125EPHB10.39186367
126PRKACG0.38245696
127CSNK2A10.38040347
128PRKACA0.37968616
129CSNK2A20.37014797
130MELK0.36710035
131CAMKK10.36491265
132PLK30.35760189
133MAPKAPK50.34755856
134CSNK1A10.34742601
135GRK70.34286069
136ABL20.34017712
137MAPK40.33882275
138STK380.33775161
139LIMK10.33513561
140ROCK10.33155916
141ITK0.33070250
142KIT0.31412702
143PRKCD0.30929227
144RET0.30902244
145CDK50.30401562
146FGFR40.30400176
147FES0.30293172
148GSK3A0.30110483
149PDGFRB0.28833025
150STK40.28368401
151PRKCZ0.27779801
152NTRK30.27716806
153PAK20.27181229
154BCKDK0.27105029
155AURKA0.27033598
156SGK4940.26705784
157SGK2230.26705784
158PRKAA10.26491403
159MAP2K10.26449630
160RPS6KA20.25766208
161PRKAA20.25337650
162CAMK10.25252582
163PRPF4B0.24678788
164CDK40.24031377

Predicted pathways (KEGG)

RankGene SetZ-score
1Glutathione metabolism_Homo sapiens_hsa004805.01508856
2Arachidonic acid metabolism_Homo sapiens_hsa005904.51251996
3Nitrogen metabolism_Homo sapiens_hsa009104.22806935
4Tryptophan metabolism_Homo sapiens_hsa003803.48736004
5Vitamin B6 metabolism_Homo sapiens_hsa007503.48082235
6Retinol metabolism_Homo sapiens_hsa008303.15306671
7Thyroid hormone synthesis_Homo sapiens_hsa049182.88787743
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.74845451
9Steroid hormone biosynthesis_Homo sapiens_hsa001402.69319505
10Ribosome_Homo sapiens_hsa030102.64799361
11Phenylalanine metabolism_Homo sapiens_hsa003602.59834272
12African trypanosomiasis_Homo sapiens_hsa051432.50006936
13DNA replication_Homo sapiens_hsa030302.37196776
14Lysosome_Homo sapiens_hsa041422.35149198
15Caffeine metabolism_Homo sapiens_hsa002322.17125470
16Butanoate metabolism_Homo sapiens_hsa006502.08264649
17Mismatch repair_Homo sapiens_hsa034302.03026038
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.01590049
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.99553960
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.85147003
21Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.82584833
22Linoleic acid metabolism_Homo sapiens_hsa005911.82363831
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.54529796
24Fatty acid degradation_Homo sapiens_hsa000711.51070134
25Other glycan degradation_Homo sapiens_hsa005111.48959725
26Steroid biosynthesis_Homo sapiens_hsa001001.47372139
27Fatty acid metabolism_Homo sapiens_hsa012121.44773278
28Arginine biosynthesis_Homo sapiens_hsa002201.43860758
29Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37070693
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33675186
31Folate biosynthesis_Homo sapiens_hsa007901.25203717
32RNA polymerase_Homo sapiens_hsa030201.23097926
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.22343669
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.20399815
35Sulfur metabolism_Homo sapiens_hsa009201.16322861
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.14100916
37Pentose phosphate pathway_Homo sapiens_hsa000301.13814426
38PPAR signaling pathway_Homo sapiens_hsa033201.13195004
39Biosynthesis of amino acids_Homo sapiens_hsa012301.12296557
40Collecting duct acid secretion_Homo sapiens_hsa049661.12085972
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09280079
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07049217
43N-Glycan biosynthesis_Homo sapiens_hsa005100.99770182
44Pyrimidine metabolism_Homo sapiens_hsa002400.98363738
45Sulfur relay system_Homo sapiens_hsa041220.96491408
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.92331535
47RNA transport_Homo sapiens_hsa030130.92164309
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.91962816
49One carbon pool by folate_Homo sapiens_hsa006700.91873072
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91692145
51Vibrio cholerae infection_Homo sapiens_hsa051100.91408421
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90651611
53Homologous recombination_Homo sapiens_hsa034400.89680853
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87882656
55Starch and sucrose metabolism_Homo sapiens_hsa005000.87492435
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.87317835
57Arginine and proline metabolism_Homo sapiens_hsa003300.87016427
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83556964
59Chemical carcinogenesis_Homo sapiens_hsa052040.83082341
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81521133
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80636545
62Phagosome_Homo sapiens_hsa041450.79031576
63Mineral absorption_Homo sapiens_hsa049780.77952303
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76428970
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76302105
66beta-Alanine metabolism_Homo sapiens_hsa004100.75690946
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74771767
68Purine metabolism_Homo sapiens_hsa002300.73597144
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71256714
70Pertussis_Homo sapiens_hsa051330.65945865
71Propanoate metabolism_Homo sapiens_hsa006400.65060986
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.64742535
73Systemic lupus erythematosus_Homo sapiens_hsa053220.59825783
74Carbon metabolism_Homo sapiens_hsa012000.56321860
75Cell cycle_Homo sapiens_hsa041100.53149567
76Glycerolipid metabolism_Homo sapiens_hsa005610.51188501
77Complement and coagulation cascades_Homo sapiens_hsa046100.49445096
78RNA degradation_Homo sapiens_hsa030180.49428803
79Tyrosine metabolism_Homo sapiens_hsa003500.49349358
80Fanconi anemia pathway_Homo sapiens_hsa034600.48655993
81Peroxisome_Homo sapiens_hsa041460.46787010
82Nucleotide excision repair_Homo sapiens_hsa034200.45641080
83Oocyte meiosis_Homo sapiens_hsa041140.45635427
84ABC transporters_Homo sapiens_hsa020100.45349027
85Rheumatoid arthritis_Homo sapiens_hsa053230.44266048
86Fat digestion and absorption_Homo sapiens_hsa049750.39970279
87Fructose and mannose metabolism_Homo sapiens_hsa000510.38427247
88Salivary secretion_Homo sapiens_hsa049700.37713864
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.37658728
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37474545
91Bile secretion_Homo sapiens_hsa049760.37155383
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.36904823
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.35077650
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34847734
95Lysine degradation_Homo sapiens_hsa003100.34460389
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33616995
97Pyruvate metabolism_Homo sapiens_hsa006200.33498850
98Metabolic pathways_Homo sapiens_hsa011000.31611335
99Staphylococcus aureus infection_Homo sapiens_hsa051500.30029867
100Non-homologous end-joining_Homo sapiens_hsa034500.29998746
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29332226
102Fatty acid biosynthesis_Homo sapiens_hsa000610.29119101
103p53 signaling pathway_Homo sapiens_hsa041150.28022397
104Glucagon signaling pathway_Homo sapiens_hsa049220.27532794
105Hedgehog signaling pathway_Homo sapiens_hsa043400.24106640
106Base excision repair_Homo sapiens_hsa034100.23676588
107Thyroid cancer_Homo sapiens_hsa052160.23378040
108Histidine metabolism_Homo sapiens_hsa003400.21878012
109Fatty acid elongation_Homo sapiens_hsa000620.21782784
110Prion diseases_Homo sapiens_hsa050200.21594570
111Insulin resistance_Homo sapiens_hsa049310.20046567
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19696191
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.18258085
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16838795
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.16754367
116ECM-receptor interaction_Homo sapiens_hsa045120.16656864
117Proteasome_Homo sapiens_hsa030500.16593286
118Gastric acid secretion_Homo sapiens_hsa049710.16233628
119Gap junction_Homo sapiens_hsa045400.15831128
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.15417518
121Protein digestion and absorption_Homo sapiens_hsa049740.15304251
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.15294607
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.07916616
124Serotonergic synapse_Homo sapiens_hsa047260.07279709
125AMPK signaling pathway_Homo sapiens_hsa041520.05897606
126Selenocompound metabolism_Homo sapiens_hsa004500.05640986
127Sphingolipid metabolism_Homo sapiens_hsa006000.02853348
128Olfactory transduction_Homo sapiens_hsa04740-0.1338189
129Amoebiasis_Homo sapiens_hsa05146-0.1281920
130GABAergic synapse_Homo sapiens_hsa04727-0.1260684
131Circadian rhythm_Homo sapiens_hsa04710-0.1072044
132Cocaine addiction_Homo sapiens_hsa05030-0.0983044
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0941022
134Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0866636
135Adipocytokine signaling pathway_Homo sapiens_hsa04920-0.0833974
136Alcoholism_Homo sapiens_hsa05034-0.0815056
137Vitamin digestion and absorption_Homo sapiens_hsa04977-0.0781192
138Galactose metabolism_Homo sapiens_hsa00052-0.0770962

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