LPAR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.80195239
2negative regulation of cell killing (GO:0031342)6.80195239
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.43932612
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.43932612
5modulation by symbiont of host immune response (GO:0052553)6.43932612
6positive regulation by symbiont of host defense response (GO:0052509)6.43932612
7modulation by symbiont of host defense response (GO:0052031)6.43932612
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.43932612
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.12074146
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.96412814
11antigen processing and presentation of endogenous antigen (GO:0019883)5.60516342
12neutrophil activation involved in immune response (GO:0002283)5.60148134
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.38381999
14leukocyte aggregation (GO:0070486)5.37304439
15respiratory burst (GO:0045730)5.35101988
16positive regulation of gamma-delta T cell activation (GO:0046645)5.28873510
17pre-miRNA processing (GO:0031054)5.22870479
18leukocyte migration involved in inflammatory response (GO:0002523)5.20085841
19detection of other organism (GO:0098543)5.17185522
20detection of bacterium (GO:0016045)5.06041733
21macrophage activation involved in immune response (GO:0002281)5.01589909
22neutrophil activation (GO:0042119)4.82640851
23response to peptidoglycan (GO:0032494)4.73900356
24negative regulation of lymphocyte mediated immunity (GO:0002707)4.58418763
25negative regulation of interleukin-12 production (GO:0032695)4.54831400
26regulation of posttranscriptional gene silencing (GO:0060147)4.42771387
27regulation of gene silencing by miRNA (GO:0060964)4.42771387
28regulation of gene silencing by RNA (GO:0060966)4.42771387
29regulation of interferon-beta biosynthetic process (GO:0045357)4.41947123
30regulation of B cell receptor signaling pathway (GO:0050855)4.41618603
31granulocyte activation (GO:0036230)4.29591881
32response to interleukin-15 (GO:0070672)4.24776984
33heterochromatin organization (GO:0070828)4.20285847
34nuclear pore organization (GO:0006999)4.19639530
35detection of external biotic stimulus (GO:0098581)4.17663885
36nuclear pore complex assembly (GO:0051292)4.17646090
37DNA unwinding involved in DNA replication (GO:0006268)4.16858762
38cellular extravasation (GO:0045123)4.11458050
39response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.09628640
40response to host immune response (GO:0052572)4.09628640
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.05337480
42viral transcription (GO:0019083)4.03168102
43activated T cell proliferation (GO:0050798)3.98524013
44neutrophil mediated immunity (GO:0002446)3.94530570
45cellular response to interleukin-15 (GO:0071350)3.94305721
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.93713687
47translational termination (GO:0006415)3.89381798
48negative regulation of leukocyte mediated immunity (GO:0002704)3.87333909
49positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.86494510
50protein localization to kinetochore (GO:0034501)3.83607841
51regulation of gamma-delta T cell activation (GO:0046643)3.82401054
52immunoglobulin mediated immune response (GO:0016064)3.81078462
53maturation of SSU-rRNA (GO:0030490)3.78973245
54microglial cell activation (GO:0001774)3.77093993
55detection of molecule of bacterial origin (GO:0032490)3.75753967
56paraxial mesoderm development (GO:0048339)3.72893266
57detection of biotic stimulus (GO:0009595)3.71849716
58myeloid cell activation involved in immune response (GO:0002275)3.69197041
59response to host defenses (GO:0052200)3.68819580
60response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.68819580
61response to host (GO:0075136)3.68819580
62negative regulation of T cell mediated immunity (GO:0002710)3.61789121
63tolerance induction (GO:0002507)3.57703638
64ribosomal small subunit biogenesis (GO:0042274)3.54323800
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.53471209
66antigen processing and presentation via MHC class Ib (GO:0002475)3.52553223
67negative regulation of phagocytosis (GO:0050765)3.49491244
68regulation of mast cell degranulation (GO:0043304)3.41364544
69macrophage activation (GO:0042116)3.41191841
70regulation of T cell tolerance induction (GO:0002664)3.40544365
71translational elongation (GO:0006414)3.40444390
72myeloid leukocyte mediated immunity (GO:0002444)3.40177901
73negative regulation of alpha-beta T cell activation (GO:0046636)3.39481450
74mitotic nuclear envelope disassembly (GO:0007077)3.35648920
75ribosomal large subunit biogenesis (GO:0042273)3.35024784
76translational initiation (GO:0006413)3.34728102
77negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31512293
78leukocyte degranulation (GO:0043299)3.31021368
79type I interferon signaling pathway (GO:0060337)3.30121371
80cellular response to type I interferon (GO:0071357)3.30121371
81regulation of tolerance induction (GO:0002643)3.30049307
82response to muramyl dipeptide (GO:0032495)3.28219851
83response to type I interferon (GO:0034340)3.26851589
84regulation of B cell differentiation (GO:0045577)3.26196590
85mitotic sister chromatid segregation (GO:0000070)3.25293155
86negative regulation of interleukin-6 production (GO:0032715)3.25187187
87pore complex assembly (GO:0046931)3.24601231
88regulation of hippo signaling (GO:0035330)3.24571971
89production of molecular mediator involved in inflammatory response (GO:0002532)3.24311231
90defense response to protozoan (GO:0042832)3.23726887
91regulation of myeloid leukocyte mediated immunity (GO:0002886)3.23499645
92negative regulation of interleukin-1 production (GO:0032692)3.22420033
93protein localization to chromosome, centromeric region (GO:0071459)3.22284094
94regulation of translational fidelity (GO:0006450)3.22179209
95DNA duplex unwinding (GO:0032508)3.21983235
96peptidyl-arginine omega-N-methylation (GO:0035247)3.21863450
97regulation of histone H3-K9 methylation (GO:0051570)3.20624397
98sister chromatid segregation (GO:0000819)3.20508112
99ribosomal small subunit assembly (GO:0000028)3.20402709
100DNA replication-dependent nucleosome assembly (GO:0006335)3.19351034
101DNA replication-dependent nucleosome organization (GO:0034723)3.19351034
102DNA geometric change (GO:0032392)3.17888152
103nuclear envelope disassembly (GO:0051081)3.17714255
104membrane disassembly (GO:0030397)3.17714255
105negative regulation of cytokine production involved in immune response (GO:0002719)3.17123811
106positive regulation of mast cell activation (GO:0033005)3.17094110
107regulation of gamma-delta T cell differentiation (GO:0045586)3.14979732
108trophectodermal cell differentiation (GO:0001829)3.14696792
109establishment of apical/basal cell polarity (GO:0035089)3.13799725
110RNA stabilization (GO:0043489)3.12374449
111mRNA stabilization (GO:0048255)3.12374449
112regulation of mast cell activation involved in immune response (GO:0033006)3.12143412
113negative regulation of RNA splicing (GO:0033119)3.12058750
114negative regulation of T-helper cell differentiation (GO:0045623)3.11088755
115negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.11088755
116cellular protein complex disassembly (GO:0043624)3.10976049
117negative regulation of innate immune response (GO:0045824)3.10814728
118regulation of mast cell activation (GO:0033003)3.09673870
119protein complex disassembly (GO:0043241)3.09574035
120positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.08586096
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.08316380
122negative thymic T cell selection (GO:0045060)3.07016904
123negative regulation of interleukin-1 beta production (GO:0032691)3.03224115
124superoxide anion generation (GO:0042554)3.02264559
125B cell mediated immunity (GO:0019724)3.01966611
126chromatin assembly (GO:0031497)3.01574772
127folic acid-containing compound biosynthetic process (GO:0009396)3.01514927
128negative T cell selection (GO:0043383)3.01394044
129gene silencing by RNA (GO:0031047)3.00877321
130dendritic cell chemotaxis (GO:0002407)3.00239464
131positive regulation of antigen processing and presentation (GO:0002579)2.98237200
132formation of translation preinitiation complex (GO:0001731)2.97617027
133negative regulation of mRNA processing (GO:0050686)2.96214025
134regulation of leukocyte degranulation (GO:0043300)2.95620254
135negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.93868079
136DNA strand elongation involved in DNA replication (GO:0006271)2.92724203
137regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92717988
138regulation of natural killer cell mediated immunity (GO:0002715)2.92717988
139viral life cycle (GO:0019058)2.92297872
140positive regulation of B cell differentiation (GO:0045579)2.90624619
141mitotic chromosome condensation (GO:0007076)2.90506076
142neutrophil chemotaxis (GO:0030593)2.89975572
143dendritic cell migration (GO:0036336)2.89696580
144negative regulation of histone methylation (GO:0031061)2.89637327
145SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.88935183
146regulation of antigen processing and presentation (GO:0002577)2.88238861
147T cell migration (GO:0072678)2.88227346
148negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87865706
149DNA replication initiation (GO:0006270)2.87674101
150interferon-gamma secretion (GO:0072643)2.84960001
151snRNA metabolic process (GO:0016073)2.84237851
152peptidyl-arginine N-methylation (GO:0035246)2.84215630
153peptidyl-arginine methylation (GO:0018216)2.84215630
154regulation of T cell mediated cytotoxicity (GO:0001914)2.84078367
155macromolecular complex disassembly (GO:0032984)2.83573319
156snRNA processing (GO:0016180)2.83256242
157positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82570037
158neutrophil migration (GO:1990266)2.82373519
159T cell homeostasis (GO:0043029)2.82220720
160regulation of stem cell maintenance (GO:2000036)2.81141976
161protein targeting to ER (GO:0045047)2.80158298
162mitotic sister chromatid cohesion (GO:0007064)2.79459827
163DNA strand elongation (GO:0022616)2.79214816
164polarized epithelial cell differentiation (GO:0030859)2.78738862
165cotranslational protein targeting to membrane (GO:0006613)2.77052801
166regulation of gene silencing (GO:0060968)2.76739232
167nuclear-transcribed mRNA catabolic process (GO:0000956)2.71526066
168histone H4-K12 acetylation (GO:0043983)2.70560916
169negative regulation of mRNA metabolic process (GO:1903312)2.70449337
170regulation of chromatin binding (GO:0035561)2.68237680
171establishment of protein localization to endoplasmic reticulum (GO:0072599)2.68073519
172nodal signaling pathway (GO:0038092)2.66644813
173regulation of RNA export from nucleus (GO:0046831)2.65240473
174positive regulation of chromosome segregation (GO:0051984)2.64327814
175dosage compensation (GO:0007549)2.64308382
176spliceosomal tri-snRNP complex assembly (GO:0000244)2.62751463
177histone arginine methylation (GO:0034969)2.62387981
178gene silencing (GO:0016458)2.61120668
179regulation of sister chromatid cohesion (GO:0007063)2.60152501
180protein-DNA complex disassembly (GO:0032986)2.60040610
181nucleosome disassembly (GO:0006337)2.60040610
182nuclear envelope organization (GO:0006998)2.59501705
183negative regulation of translational initiation (GO:0045947)2.58874254
184mRNA catabolic process (GO:0006402)2.58270151
185ribonucleoprotein complex biogenesis (GO:0022613)2.58184108
186establishment of monopolar cell polarity (GO:0061162)2.58183424
187establishment or maintenance of monopolar cell polarity (GO:0061339)2.58183424
188RNA catabolic process (GO:0006401)2.57834423
189positive regulation of SMAD protein import into nucleus (GO:0060391)2.56919985
190DNA conformation change (GO:0071103)2.56137274
191regulation of mRNA stability (GO:0043488)2.55297771
192mitotic G1 DNA damage checkpoint (GO:0031571)2.54775010
193IMP biosynthetic process (GO:0006188)2.54728491
194DNA replication checkpoint (GO:0000076)2.54481792
195mitotic metaphase plate congression (GO:0007080)2.53246371
196ncRNA catabolic process (GO:0034661)2.53189011
197protein localization to endoplasmic reticulum (GO:0070972)2.51569090
198hippo signaling (GO:0035329)2.51528575
199planar cell polarity pathway involved in neural tube closure (GO:0090179)2.51089373
200mRNA transport (GO:0051028)2.45347683

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.90144741
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.66702147
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.34257240
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.16380434
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.56982622
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.51138291
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.46126699
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.39972636
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.12136215
10BP1_19119308_ChIP-ChIP_Hs578T_Human3.03795969
11E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92951708
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.86329967
13MYC_22102868_ChIP-Seq_BL_Human2.84755036
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76306079
15VDR_24763502_ChIP-Seq_THP-1_Human2.67012260
16SPI1_23547873_ChIP-Seq_NB4_Human2.61992359
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60793605
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.58862395
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56433901
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.55879354
21EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47418226
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.46835648
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.44132227
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.40684744
25RUNX_20019798_ChIP-Seq_JUKART_Human2.31954795
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.28324374
27SPI1_23127762_ChIP-Seq_K562_Human2.26975035
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.25439922
29* MAF_26560356_Chip-Seq_TH2_Human2.19497120
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10787054
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10107292
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.09101443
33STAT6_21828071_ChIP-Seq_BEAS2B_Human2.04801598
34XRN2_22483619_ChIP-Seq_HELA_Human1.99049495
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98256377
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97597176
37MYB_26560356_Chip-Seq_TH2_Human1.96338955
38TP63_19390658_ChIP-ChIP_HaCaT_Human1.95582638
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95172628
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.90574578
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88838222
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88838222
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88838222
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85861876
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.85845903
46VDR_21846776_ChIP-Seq_THP-1_Human1.80873682
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79918902
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78803203
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76765033
50MYB_26560356_Chip-Seq_TH1_Human1.74124685
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72998679
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71235242
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70923331
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.70557120
55* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68521414
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.68492871
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67348154
58AR_21909140_ChIP-Seq_LNCAP_Human1.66616185
59SCL_19346495_ChIP-Seq_HPC-7_Human1.65072932
60LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59707174
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59389754
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58042632
63FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56312752
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55949963
65BCL6_27268052_Chip-Seq_Bcells_Human1.55361626
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.54746041
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54603485
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54199161
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53917088
70GATA3_27048872_Chip-Seq_THYMUS_Human1.51808877
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51740170
72CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51697772
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51178128
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50913393
75KDM5A_27292631_Chip-Seq_BREAST_Human1.48489088
76STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47861295
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47831729
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46673247
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46566414
80TCF7_22412390_ChIP-Seq_EML_Mouse1.46433221
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45909953
82* LXR_22292898_ChIP-Seq_THP-1_Human1.45086809
83ELF1_17652178_ChIP-ChIP_JURKAT_Human1.43149365
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41504523
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.41153465
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.37555073
87TTF2_22483619_ChIP-Seq_HELA_Human1.36875803
88PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35771131
89SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35743199
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.35346307
91EZH2_22144423_ChIP-Seq_EOC_Human1.34969506
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33175313
93GATA1_19941827_ChIP-Seq_MEL_Mouse1.31473317
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.31228334
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30788750
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29882412
97VDR_24787735_ChIP-Seq_THP-1_Human1.28666500
98ZNF263_19887448_ChIP-Seq_K562_Human1.28379702
99KDM2B_26808549_Chip-Seq_DND41_Human1.28313060
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25017386
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25014451
102BCOR_27268052_Chip-Seq_Bcells_Human1.25012872
103SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.24159584
104CIITA_25753668_ChIP-Seq_RAJI_Human1.23503519
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23437555
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22947935
107ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22821521
108ELK3_25401928_ChIP-Seq_HUVEC_Human1.22521471
109KDM2B_26808549_Chip-Seq_K562_Human1.20786050
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20517944
111KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20360974
112NANOG_21062744_ChIP-ChIP_HESCs_Human1.19897860
113ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19301454
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18889850
115SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.18292493
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.17459699
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17314067
118ETS1_20019798_ChIP-Seq_JURKAT_Human1.16388960
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.16223542
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15613577
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15508569
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15216823
123CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15131532
124STAT3_1855785_ChIP-Seq_MESCs_Mouse1.14793347
125NOTCH1_21737748_ChIP-Seq_TLL_Human1.14472123
126DCP1A_22483619_ChIP-Seq_HELA_Human1.13916087
127UTX_26944678_Chip-Seq_JUKART_Human1.13904758
128P68_20966046_ChIP-Seq_HELA_Human1.13886730
129SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13701961
130TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13350583
131RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12789363
132MAF_26560356_Chip-Seq_TH1_Human1.12649744
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12486031
134ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12458435
135GATA3_26560356_Chip-Seq_TH2_Human1.12182420
136* ATF3_27146783_Chip-Seq_COLON_Human1.12123577
137EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12063224
138CHD1_26751641_Chip-Seq_LNCaP_Human1.11764843
139CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11005544
140ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10799912
141SA1_27219007_Chip-Seq_Bcells_Human1.10345777
142KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10314210
143TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08671996
144E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08629436
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07215815
146GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07045836
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06991135
148TFEB_21752829_ChIP-Seq_HELA_Human1.05932419
149RACK7_27058665_Chip-Seq_MCF-7_Human1.05378063
150CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05133021
151SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04392057
152HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03105248
153TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02311594
154NCOR1_26117541_ChIP-Seq_K562_Human1.02298978
155FOXP3_21729870_ChIP-Seq_TREG_Human1.02185787
156GABP_19822575_ChIP-Seq_HepG2_Human1.01564091
157GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01391522
158CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00753467
159EST1_17652178_ChIP-ChIP_JURKAT_Human1.00678631
160PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99483486
161CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99134947
162RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.98412255
163E2F1_20622854_ChIP-Seq_HELA_Human0.97585036
164KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97188618
165HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.96939513
166EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96696596
167SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94619573
168PHF8_20622854_ChIP-Seq_HELA_Human0.94098520
169CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94039084
170POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93325920
171CTCF_21964334_ChIP-Seq_BJAB-B_Human0.92684193
172PU_27001747_Chip-Seq_BMDM_Mouse0.92519572
173E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92181020
174SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.91798897
175SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90617678
176VDR_23849224_ChIP-Seq_CD4+_Human0.90551762
177TP53_22127205_ChIP-Seq_IMR90_Human0.90188116
178YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89734928
179NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87623194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.71920405
2MP0003436_decreased_susceptibility_to4.20280783
3MP0003303_peritoneal_inflammation3.37463905
4MP0001835_abnormal_antigen_presentation3.09232176
5MP0005671_abnormal_response_to3.01174774
6MP0002419_abnormal_innate_immunity2.94881817
7MP0003705_abnormal_hypodermis_morpholog2.79558469
8MP0004957_abnormal_blastocyst_morpholog2.77921130
9MP0001800_abnormal_humoral_immune2.74920523
10MP0010352_gastrointestinal_tract_polyps2.73335738
11MP0005025_abnormal_response_to2.71837818
12MP0010094_abnormal_chromosome_stability2.68573221
13MP0003111_abnormal_nucleus_morphology2.65444423
14MP0003693_abnormal_embryo_hatching2.64962829
15MP0002277_abnormal_respiratory_mucosa2.64039639
16MP0001790_abnormal_immune_system2.61959581
17MP0005387_immune_system_phenotype2.61959581
18MP0005076_abnormal_cell_differentiation2.56101880
19MP0000685_abnormal_immune_system2.52115940
20MP0002420_abnormal_adaptive_immunity2.43885674
21MP0002723_abnormal_immune_serum2.41861872
22MP0001819_abnormal_immune_cell2.41834750
23MP0005000_abnormal_immune_tolerance2.41409761
24MP0009785_altered_susceptibility_to2.36604994
25MP0003077_abnormal_cell_cycle2.31904231
26MP0006082_CNS_inflammation2.29536181
27MP0002452_abnormal_antigen_presenting2.26244174
28MP0000537_abnormal_urethra_morphology2.26119421
29MP0008057_abnormal_DNA_replication2.24579939
30MP0010030_abnormal_orbit_morphology2.18212464
31MP0002132_abnormal_respiratory_system2.15788027
32MP0003763_abnormal_thymus_physiology2.02500142
33MP0002148_abnormal_hypersensitivity_rea1.94124036
34MP0001730_embryonic_growth_arrest1.93867078
35MP0003123_paternal_imprinting1.93199314
36MP0008260_abnormal_autophagy1.93031018
37MP0009053_abnormal_anal_canal1.91407399
38MP0001533_abnormal_skeleton_physiology1.88647432
39MP0002405_respiratory_system_inflammati1.88115992
40MP0004197_abnormal_fetal_growth/weight/1.87385392
41MP0003890_abnormal_embryonic-extraembry1.86964334
42MP0000716_abnormal_immune_system1.80406157
43MP0003941_abnormal_skin_development1.75614317
44MP0002796_impaired_skin_barrier1.74271199
45MP0002084_abnormal_developmental_patter1.73875170
46MP0002398_abnormal_bone_marrow1.72573922
47MP0000350_abnormal_cell_proliferation1.71967440
48MP0003119_abnormal_digestive_system1.70559870
49MP0004381_abnormal_hair_follicle1.70512288
50MP0005380_embryogenesis_phenotype1.69965049
51MP0001672_abnormal_embryogenesis/_devel1.69965049
52MP0005501_abnormal_skin_physiology1.62129338
53MP0003191_abnormal_cellular_cholesterol1.61163794
54MP0002085_abnormal_embryonic_tissue1.61075437
55MP0003984_embryonic_growth_retardation1.57531056
56MP0001293_anophthalmia1.57026230
57MP0003866_abnormal_defecation1.56906405
58MP0003786_premature_aging1.56674120
59MP0002088_abnormal_embryonic_growth/wei1.55253428
60MP0003566_abnormal_cell_adhesion1.54871421
61MP0008007_abnormal_cellular_replicative1.54605022
62MP0002086_abnormal_extraembryonic_tissu1.53678386
63MP0008058_abnormal_DNA_repair1.53434896
64MP0001697_abnormal_embryo_size1.53166851
65MP0008932_abnormal_embryonic_tissue1.50251948
66MP0010155_abnormal_intestine_physiology1.50219983
67MP0000689_abnormal_spleen_morphology1.48464846
68MP0001845_abnormal_inflammatory_respons1.45971536
69MP0002722_abnormal_immune_system1.45547938
70MP0000465_gastrointestinal_hemorrhage1.43923397
71MP0009278_abnormal_bone_marrow1.43863128
72MP0003315_abnormal_perineum_morphology1.42904252
73MP0003567_abnormal_fetal_cardiomyocyte1.42675590
74MP0004133_heterotaxia1.41909249
75MP0010307_abnormal_tumor_latency1.40083584
76MP0009764_decreased_sensitivity_to1.39423770
77MP0009333_abnormal_splenocyte_physiolog1.38880140
78MP0002429_abnormal_blood_cell1.35059712
79MP0002653_abnormal_ependyma_morphology1.34201332
80MP0000428_abnormal_craniofacial_morphol1.33829128
81MP0003121_genomic_imprinting1.32501030
82MP0005464_abnormal_platelet_physiology1.31607081
83MP0005310_abnormal_salivary_gland1.30748911
84MP0004883_abnormal_blood_vessel1.30567293
85MP0005623_abnormal_meninges_morphology1.30195732
86MP0001216_abnormal_epidermal_layer1.28408260
87MP0003011_delayed_dark_adaptation1.27570835
88MP0010234_abnormal_vibrissa_follicle1.26747976
89MP0001849_ear_inflammation1.25338158
90MP0003453_abnormal_keratinocyte_physiol1.24941863
91MP0002080_prenatal_lethality1.24820149
92MP0008877_abnormal_DNA_methylation1.24433814
93MP0004264_abnormal_extraembryonic_tissu1.22906323
94MP0008995_early_reproductive_senescence1.22737957
95MP0004808_abnormal_hematopoietic_stem1.21720530
96MP0002111_abnormal_tail_morphology1.21361317
97MP0000377_abnormal_hair_follicle1.20963425
98MP0002092_abnormal_eye_morphology1.20279441
99MP0003115_abnormal_respiratory_system1.20202946
100MP0002098_abnormal_vibrissa_morphology1.17937120
101MP0008469_abnormal_protein_level1.17799680
102MP0003172_abnormal_lysosome_physiology1.16275789
103MP0001986_abnormal_taste_sensitivity1.15383734
104MP0000383_abnormal_hair_follicle1.15161434
105MP0001873_stomach_inflammation1.14712243
106MP0002697_abnormal_eye_size1.14314472
107MP0000490_abnormal_crypts_of1.14024420
108MP0003828_pulmonary_edema1.13689892
109MP0005023_abnormal_wound_healing1.11518059
110MP0003787_abnormal_imprinting1.10696819
111MP0002396_abnormal_hematopoietic_system1.09413643
112MP0001663_abnormal_digestive_system1.08275001
113MP0004858_abnormal_nervous_system1.07543423
114MP0004947_skin_inflammation1.07406850
115MP0002249_abnormal_larynx_morphology1.05260854
116MP0002060_abnormal_skin_morphology1.05210200
117MP0003937_abnormal_limbs/digits/tail_de1.04653282
118MP0000432_abnormal_head_morphology1.03459458
119MP0004510_myositis1.02846207
120MP0003942_abnormal_urinary_system1.00540994
121MP0010678_abnormal_skin_adnexa0.98772433
122MP0003935_abnormal_craniofacial_develop0.98017159
123MP0003878_abnormal_ear_physiology0.97878198
124MP0005377_hearing/vestibular/ear_phenot0.97878198
125MP0005075_abnormal_melanosome_morpholog0.97862996
126MP0003385_abnormal_body_wall0.97309129
127MP0000733_abnormal_muscle_development0.96726571
128MP0000703_abnormal_thymus_morphology0.96546409
129MP0003183_abnormal_peptide_metabolism0.95875114
130MP0002234_abnormal_pharynx_morphology0.95449936
131MP0000313_abnormal_cell_death0.95090283
132MP0002210_abnormal_sex_determination0.94606456
133MP0002009_preneoplasia0.94176090
134MP0001145_abnormal_male_reproductive0.94062555
135MP0000467_abnormal_esophagus_morphology0.93797396
136MP0002254_reproductive_system_inflammat0.93670651
137MP0002019_abnormal_tumor_incidence0.93383473
138MP0008004_abnormal_stomach_pH0.93013911
139MP0001286_abnormal_eye_development0.91782715
140MP0000049_abnormal_middle_ear0.91728394
141MP0003936_abnormal_reproductive_system0.91463296
142MP0002282_abnormal_trachea_morphology0.89918878
143MP0002928_abnormal_bile_duct0.89370124
144MP0001915_intracranial_hemorrhage0.87923417
145MP0005248_abnormal_Harderian_gland0.86879667
146MP0003755_abnormal_palate_morphology0.86677959
147MP0001851_eye_inflammation0.86543299
148MP0001545_abnormal_hematopoietic_system0.84664498
149MP0005397_hematopoietic_system_phenotyp0.84664498
150MP0009672_abnormal_birth_weight0.84408231
151MP0003221_abnormal_cardiomyocyte_apopto0.82430569
152MP0000762_abnormal_tongue_morphology0.82178372
153MP0009703_decreased_birth_body0.81500224
154MP0004272_abnormal_basement_membrane0.80321631
155MP0002822_catalepsy0.80293731
156MP0002925_abnormal_cardiovascular_devel0.79188404
157MP0009765_abnormal_xenobiotic_induced0.78816268
158MP0000647_abnormal_sebaceous_gland0.77829253
159MP0002932_abnormal_joint_morphology0.77680009
160MP0003300_gastrointestinal_ulcer0.77072846
161MP0005367_renal/urinary_system_phenotyp0.76866359
162MP0000516_abnormal_urinary_system0.76866359
163MP0000858_altered_metastatic_potential0.76373668
164MP0003122_maternal_imprinting0.75283761
165MP0002138_abnormal_hepatobiliary_system0.73668191
166MP0003938_abnormal_ear_development0.73442883
167MP0005390_skeleton_phenotype0.73285742
168MP0003806_abnormal_nucleotide_metabolis0.72989255
169MP0002998_abnormal_bone_remodeling0.72978869
170MP0002102_abnormal_ear_morphology0.71853276
171MP0003880_abnormal_central_pattern0.67958071
172MP0005381_digestive/alimentary_phenotyp0.66529038
173MP0000470_abnormal_stomach_morphology0.66243757
174MP0004742_abnormal_vestibular_system0.65431804
175MP0006292_abnormal_olfactory_placode0.61335282
176MP0003075_altered_response_to0.60637172
177MP0005083_abnormal_biliary_tract0.60198581
178MP0006035_abnormal_mitochondrial_morpho0.58936964
179MP0002163_abnormal_gland_morphology0.57095622
180MP0004142_abnormal_muscle_tone0.56663152
181MP0005164_abnormal_response_to0.54804201
182MP0008874_decreased_physiological_sensi0.54540067
183MP0005084_abnormal_gallbladder_morpholo0.54311244
184MP0003136_yellow_coat_color0.53558715
185MP0001485_abnormal_pinna_reflex0.53300706
186MP0000343_altered_response_to0.49277319
187MP0009763_increased_sensitivity_to0.48997850

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.64985142
2Recurrent abscess formation (HP:0002722)6.08772357
3Recurrent bacterial skin infections (HP:0005406)6.03440974
4Myositis (HP:0100614)6.02581197
5Stomatitis (HP:0010280)5.77568450
6Orchitis (HP:0100796)5.63522996
7Abnormality of macrophages (HP:0004311)5.39868477
8Retrobulbar optic neuritis (HP:0100654)5.38550466
9Optic neuritis (HP:0100653)5.38550466
10Elevated erythrocyte sedimentation rate (HP:0003565)5.37005478
11Recurrent gram-negative bacterial infections (HP:0005420)4.77798533
12Hypochromic microcytic anemia (HP:0004840)4.75206939
13Chronic obstructive pulmonary disease (HP:0006510)4.36676263
14Obstructive lung disease (HP:0006536)4.36676263
15Mediastinal lymphadenopathy (HP:0100721)4.22826994
16Encephalitis (HP:0002383)4.12955947
17Hyperacusis (HP:0010780)4.11531353
18Recurrent fungal infections (HP:0002841)3.89912815
19Meningitis (HP:0001287)3.83791399
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.83428085
21Keratoconjunctivitis sicca (HP:0001097)3.81283924
22Hypochromic anemia (HP:0001931)3.76092861
23Renal duplication (HP:0000075)3.72780783
24Recurrent skin infections (HP:0001581)3.68733707
25Gastrointestinal infarctions (HP:0005244)3.66496143
26Keratoconjunctivitis (HP:0001096)3.61360701
27Increased IgE level (HP:0003212)3.56002453
28Chronic mucocutaneous candidiasis (HP:0002728)3.31269979
29Recurrent cutaneous fungal infections (HP:0011370)3.31269979
30Urticaria (HP:0001025)3.28294034
31Overriding aorta (HP:0002623)3.24508688
32Chronic otitis media (HP:0000389)3.24507844
33Reticulocytopenia (HP:0001896)3.23977990
34Gingivitis (HP:0000230)3.15922109
35Increased IgM level (HP:0003496)3.07058681
36Elfin facies (HP:0004428)3.05375888
37Vasculitis (HP:0002633)3.04822708
38Increased nuchal translucency (HP:0010880)3.03967373
39Panhypogammaglobulinemia (HP:0003139)2.98398499
40Renovascular hypertension (HP:0100817)2.98327133
41Episodic fever (HP:0001954)2.94200720
42Spontaneous hematomas (HP:0007420)2.86679358
43Prolonged bleeding time (HP:0003010)2.82699735
44Microcytic anemia (HP:0001935)2.78702794
45Selective tooth agenesis (HP:0001592)2.77791778
46Chest pain (HP:0100749)2.68475615
47Pustule (HP:0200039)2.67810034
48Anorexia (HP:0002039)2.65976761
49Ependymoma (HP:0002888)2.65405133
50Hemoptysis (HP:0002105)2.62679687
51Deviation of the thumb (HP:0009603)2.60664773
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60653782
53Short 4th metacarpal (HP:0010044)2.60653782
54Leukocytosis (HP:0001974)2.59177368
55Proximal placement of thumb (HP:0009623)2.54085555
56Medulloblastoma (HP:0002885)2.49276353
57Flat cornea (HP:0007720)2.47627315
58Missing ribs (HP:0000921)2.47080632
5911 pairs of ribs (HP:0000878)2.46887868
60Abnormality of cells of the erythroid lineage (HP:0012130)2.42689336
61Premature loss of primary teeth (HP:0006323)2.39536781
62Pulmonary infiltrates (HP:0002113)2.37859861
63Abnormality of the diencephalon (HP:0010662)2.37657444
64Lymphopenia (HP:0001888)2.35219694
65Colon cancer (HP:0003003)2.33369679
66Cellulitis (HP:0100658)2.30453948
67Basal cell carcinoma (HP:0002671)2.30168898
68Sepsis (HP:0100806)2.29534377
69Insomnia (HP:0100785)2.28522028
70Absent thumb (HP:0009777)2.22549396
71Curly hair (HP:0002212)2.21964407
72Abnormality of the aortic arch (HP:0012303)2.21510268
73T lymphocytopenia (HP:0005403)2.21507600
74Hypergammaglobulinemia (HP:0010702)2.19016976
75Ectopic kidney (HP:0000086)2.14539922
76Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14399318
77Abnormality of the pleura (HP:0002103)2.14333170
78Stomach cancer (HP:0012126)2.12768474
79Inflammation of the large intestine (HP:0002037)2.11968945
80Rectal prolapse (HP:0002035)2.10857181
81Abnormality of T cell number (HP:0011839)2.10329437
82Abnormality of T cells (HP:0002843)2.09898337
83Abnormal number of incisors (HP:0011064)2.09715291
84Chromsome breakage (HP:0040012)2.09087677
85Abnormality of cells of the lymphoid lineage (HP:0012140)2.08613519
86Gastrointestinal inflammation (HP:0004386)2.07569471
87Pulmonary embolism (HP:0002204)2.07381126
88Pseudobulbar signs (HP:0002200)2.04402794
89Severe visual impairment (HP:0001141)2.04053154
90Chronic sinusitis (HP:0011109)2.03323571
91Biliary tract neoplasm (HP:0100574)2.02768745
92Keratitis (HP:0000491)2.02698418
93Petechiae (HP:0000967)2.01884184
94Astrocytoma (HP:0009592)2.00446355
95Abnormality of the astrocytes (HP:0100707)2.00446355
96Abnormality of the gastric mucosa (HP:0004295)1.99503285
97Gingival bleeding (HP:0000225)1.99479823
98Poikiloderma (HP:0001029)1.94344298
99Peritonitis (HP:0002586)1.94301957
100Anomalous pulmonary venous return (HP:0010772)1.93957746
101Abnormality of the fingertips (HP:0001211)1.93169186
102Granulocytopenia (HP:0001913)1.92104721
103Abnormality of the carotid arteries (HP:0005344)1.92070874
104Spina bifida occulta (HP:0003298)1.91980804
105Rib fusion (HP:0000902)1.91811459
106Bladder diverticulum (HP:0000015)1.91296988
107Skin tags (HP:0010609)1.90754041
108Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90473338
109Absent radius (HP:0003974)1.89965081
110Recurrent sinusitis (HP:0011108)1.88927160
111Abnormality of the distal phalanx of the thumb (HP:0009617)1.87852166
112Neoplasm of striated muscle (HP:0009728)1.87167709
113Aplasia/hypoplasia of the humerus (HP:0006507)1.86808492
114Abnormal vertebral ossification (HP:0100569)1.86256523
115Arterial thrombosis (HP:0004420)1.86174515
116Papilledema (HP:0001085)1.85988154
117Osteomyelitis (HP:0002754)1.85310276
118Alveolar cell carcinoma (HP:0006519)1.85211305
119IgM deficiency (HP:0002850)1.83721957
120Amyloidosis (HP:0011034)1.83586813
121Esophageal atresia (HP:0002032)1.82678166
122Trismus (HP:0000211)1.82488999
123Bowel diverticulosis (HP:0005222)1.82413405
124Bicuspid aortic valve (HP:0001647)1.82254645
125Patellar aplasia (HP:0006443)1.81547945
126Hepatosplenomegaly (HP:0001433)1.81497639
127Megalocornea (HP:0000485)1.81439803
128Milia (HP:0001056)1.81403645
129Recurrent viral infections (HP:0004429)1.80923980
130Increased cerebral lipofuscin (HP:0011813)1.80642851
131Aplasia involving forearm bones (HP:0009822)1.80624736
132Absent forearm bone (HP:0003953)1.80624736
133Gangrene (HP:0100758)1.80603231
134Supernumerary ribs (HP:0005815)1.79912209
135Preauricular skin tag (HP:0000384)1.79293871
136Disinhibition (HP:0000734)1.79262887
137Natal tooth (HP:0000695)1.79213099
138Short humerus (HP:0005792)1.78810999
139Metaphyseal cupping (HP:0003021)1.77546268
140Acne (HP:0001061)1.77468903
141Neoplasm of the tracheobronchial system (HP:0100552)1.77305888
142Malignant gastrointestinal tract tumors (HP:0006749)1.77042801
143Gastrointestinal carcinoma (HP:0002672)1.77042801
144Rhabdomyosarcoma (HP:0002859)1.77008015
145Atresia of the external auditory canal (HP:0000413)1.76948925
146Ankyloglossia (HP:0010296)1.75489617
147Abnormality of incisor morphology (HP:0011063)1.75335051
148Abnormality of the 4th metacarpal (HP:0010012)1.75131423
149Slow saccadic eye movements (HP:0000514)1.74963273
150Abnormality of DNA repair (HP:0003254)1.74072778
151Syringomyelia (HP:0003396)1.73769087
152Spinal cord lesions (HP:0100561)1.73769087
153Epistaxis (HP:0000421)1.73687854
154Skin ulcer (HP:0200042)1.73566458
155Aplasia/Hypoplasia of the patella (HP:0006498)1.73452092
156Fragile nails (HP:0001808)1.73211057
157Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72899160
158Hallux valgus (HP:0001822)1.72723566
159Overlapping toe (HP:0001845)1.72669876
160Patellar dislocation (HP:0002999)1.71606688
161Arnold-Chiari malformation (HP:0002308)1.70742410
162Abnormality of T cell physiology (HP:0011840)1.70706192
163Abnormality of the endocardium (HP:0004306)1.69643754
164Loss of speech (HP:0002371)1.67662993
165Deviation of the hallux (HP:0010051)1.67520765
166Broad thumb (HP:0011304)1.66917052
167Tracheoesophageal fistula (HP:0002575)1.66702785
168Abnormality of the heme biosynthetic pathway (HP:0010472)1.66496184
169Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66188678
170Recurrent bronchitis (HP:0002837)1.66150994
171Abnormal number of erythroid precursors (HP:0012131)1.65784765
172Stenosis of the external auditory canal (HP:0000402)1.65460008
173Woolly hair (HP:0002224)1.64868559
174Facial hemangioma (HP:0000329)1.64405165
175Pallor (HP:0000980)1.64202447
176Ovarian neoplasm (HP:0100615)1.63756901
177Abnormal hemoglobin (HP:0011902)1.63396608
178Oligodontia (HP:0000677)1.62832303
179Large earlobe (HP:0009748)1.61703372
180Vertigo (HP:0002321)1.61435223
181Sex reversal (HP:0012245)1.60369064
182Abnormal sex determination (HP:0012244)1.60369064
183Increased serum ferritin (HP:0003281)1.59822571
184Pointed chin (HP:0000307)1.59302974
185Abnormality of the pericardium (HP:0001697)1.59157779
186Heterotopia (HP:0002282)1.58366349
187Blepharitis (HP:0000498)1.58063654
188Neoplasm of the oral cavity (HP:0100649)1.57911181
189Supernumerary bones of the axial skeleton (HP:0009144)1.57333198
190Hypotrichosis (HP:0001006)1.56029216
191High anterior hairline (HP:0009890)1.56011783
192Abnormality of the preputium (HP:0100587)1.55088842
193Meckel diverticulum (HP:0002245)1.54935634
194Long palpebral fissure (HP:0000637)1.52742754
195Abnormal lung lobation (HP:0002101)1.52697882
196Nasal polyposis (HP:0100582)1.52693483
197Sparse scalp hair (HP:0002209)1.52470850

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.02163427
2RIPK44.03890392
3TAOK23.72874638
4IRAK43.55927049
5EEF2K3.49291374
6MAP3K103.17867970
7CDC73.01286758
8RPS6KB22.78266836
9SIK22.62341287
10CSK2.51949451
11EPHB12.41978341
12FES2.41597193
13BLK2.34995216
14CDK72.22322764
15STK102.20699221
16BRD42.16741626
17PKN22.14444098
18NEK22.06355769
19SIK32.06081022
20EPHA22.05651727
21FGR1.85448741
22CDK191.80811174
23LATS11.73474371
24TXK1.72505214
25MAP2K61.68517714
26BUB11.67926951
27LRRK21.64049177
28PASK1.57082693
29ICK1.57079794
30CDK41.50309601
31TTK1.47319237
32MKNK11.44339627
33LATS21.42094192
34MAP4K11.41128017
35TRIB31.41020299
36ALK1.39564040
37MARK31.37516203
38TLK11.35052712
39MKNK21.33294692
40MTOR1.32443868
41MARK21.32262973
42LYN1.31226968
43MAP3K81.29079229
44IKBKE1.28187450
45WEE11.27077210
46STK31.25130901
47JAK31.23404661
48RPS6KA41.22979714
49ATR1.22897586
50PTK61.21916610
51PRPF4B1.21752450
52SRPK11.20750274
53MAP3K51.18033865
54CHEK11.17560393
55SYK1.16630285
56GRK61.16132931
57CDK61.14452393
58PAK41.14322912
59ERN11.13594980
60LCK1.12166617
61MATK1.11387329
62MAP3K61.10854144
63JAK21.09592564
64EPHA31.08544335
65TYRO31.08423234
66PLK11.08354539
67EPHB21.05953566
68DYRK21.03877949
69AURKB1.03752798
70PRKD21.03651461
71MAP3K31.02022886
72ACVR1B0.99120390
73CHEK20.98891945
74TBK10.97828799
75PIM10.97121594
76IRAK10.95089072
77CLK10.94979670
78TGFBR10.94568390
79TAOK30.93104663
80MAP2K30.92795348
81MAP4K20.92134411
82BMX0.91309388
83STK110.90438915
84TSSK60.87630962
85PDGFRB0.87304666
86DYRK30.87014685
87MAPKAPK30.85445878
88IRAK20.84396755
89MAP2K40.83228594
90PINK10.82793388
91PAK20.81532142
92CDK20.81284019
93TTN0.80767602
94ITK0.80409643
95TESK20.79883920
96PDGFRA0.79775463
97STK40.79275542
98IKBKB0.78548881
99AURKA0.77260781
100ATM0.74616449
101FLT30.74143154
102KSR10.70257990
103PRKCI0.69705560
104TYK20.68167638
105PRKCZ0.68042127
106BTK0.67067381
107YES10.67066432
108TESK10.66728819
109KSR20.66549948
110KIT0.65271295
111FGFR10.65003499
112PLK40.64476313
113MAP3K110.63832958
114MAP3K70.62659291
115FYN0.62316802
116PRKCQ0.62048310
117MAP3K10.61552960
118MELK0.60912006
119EIF2AK10.60905648
120CDK90.60397268
121MAP3K140.58761640
122RPS6KA10.58515275
123CHUK0.57435237
124DDR20.56719009
125MAPK130.56351674
126NME10.54582954
127DYRK1B0.53982142
128SMG10.53685575
129CDK10.53609400
130TAOK10.53170274
131PAK10.52600276
132JAK10.50885745
133AKT20.50812922
134ILK0.49170175
135EIF2AK30.47942203
136WNK30.47190664
137PLK30.47071865
138RPS6KC10.46651225
139RPS6KL10.46651225
140TNK20.45825629
141NTRK20.44863334
142TEC0.43682212
143PDK10.43566864
144MST40.43321145
145MAPKAPK20.42609282
146NLK0.42337662
147HCK0.42202413
148MAPK70.41956801
149SIK10.41846766
150ZAP700.41439141
151PTK20.41039612
152RIPK10.40390950
153CSF1R0.40288676
154CSNK1E0.40075715
155CSNK1D0.39696461
156NEK10.39235471
157HIPK20.38670147
158MAPK10.38276226
159RPS6KA20.37912879
160RPS6KA60.37410109
161PRKCD0.32917434
162GRK70.32293008
163MAPK120.28232477
164MAP2K70.27047694
165CAMKK10.26903162
166DAPK20.23984215
167CDC42BPA0.22217858

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.16194197
2Mismatch repair_Homo sapiens_hsa034303.03117708
3Ribosome_Homo sapiens_hsa030102.90626863
4Leishmaniasis_Homo sapiens_hsa051402.76749751
5RNA transport_Homo sapiens_hsa030132.63930692
6Spliceosome_Homo sapiens_hsa030402.57233021
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52026423
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.50400389
9Staphylococcus aureus infection_Homo sapiens_hsa051502.44315474
10One carbon pool by folate_Homo sapiens_hsa006702.32299499
11Cell cycle_Homo sapiens_hsa041102.24879589
12Base excision repair_Homo sapiens_hsa034102.20408785
13Toll-like receptor signaling pathway_Homo sapiens_hsa046202.09472094
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.07929039
15Tuberculosis_Homo sapiens_hsa051522.05285892
16Basal cell carcinoma_Homo sapiens_hsa052172.05023693
17Homologous recombination_Homo sapiens_hsa034402.01504014
18Graft-versus-host disease_Homo sapiens_hsa053322.00968366
19mRNA surveillance pathway_Homo sapiens_hsa030151.99981616
20Allograft rejection_Homo sapiens_hsa053301.98770008
21Nucleotide excision repair_Homo sapiens_hsa034201.93328162
22Malaria_Homo sapiens_hsa051441.91061294
23Chemokine signaling pathway_Homo sapiens_hsa040621.90666326
24Autoimmune thyroid disease_Homo sapiens_hsa053201.86350653
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85099724
26Hippo signaling pathway_Homo sapiens_hsa043901.62991965
27Fanconi anemia pathway_Homo sapiens_hsa034601.60524859
28MicroRNAs in cancer_Homo sapiens_hsa052061.57652756
29Hematopoietic cell lineage_Homo sapiens_hsa046401.54635227
30Small cell lung cancer_Homo sapiens_hsa052221.54133018
31p53 signaling pathway_Homo sapiens_hsa041151.53259375
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52416823
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.52013263
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.51452763
35Hedgehog signaling pathway_Homo sapiens_hsa043401.50859109
36RNA polymerase_Homo sapiens_hsa030201.50641614
37Chronic myeloid leukemia_Homo sapiens_hsa052201.47110626
38Phagosome_Homo sapiens_hsa041451.44825383
39Notch signaling pathway_Homo sapiens_hsa043301.42886889
40African trypanosomiasis_Homo sapiens_hsa051431.37743227
41TNF signaling pathway_Homo sapiens_hsa046681.34242243
42Adherens junction_Homo sapiens_hsa045201.33741648
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33740586
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31791285
45HTLV-I infection_Homo sapiens_hsa051661.30441651
46Type I diabetes mellitus_Homo sapiens_hsa049401.26622511
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23810962
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19052537
49Bladder cancer_Homo sapiens_hsa052191.17550931
50Thyroid cancer_Homo sapiens_hsa052161.17338667
51Acute myeloid leukemia_Homo sapiens_hsa052211.17023590
52Antigen processing and presentation_Homo sapiens_hsa046121.16451341
53Proteoglycans in cancer_Homo sapiens_hsa052051.15186132
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13779226
55Herpes simplex infection_Homo sapiens_hsa051681.13032138
56RNA degradation_Homo sapiens_hsa030181.12779582
57Regulation of autophagy_Homo sapiens_hsa041401.12774014
58Viral carcinogenesis_Homo sapiens_hsa052031.11702181
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11499070
60TGF-beta signaling pathway_Homo sapiens_hsa043501.10395292
61Lysine degradation_Homo sapiens_hsa003101.09780392
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07036510
63Endometrial cancer_Homo sapiens_hsa052131.03910566
64Central carbon metabolism in cancer_Homo sapiens_hsa052301.03303097
65Salmonella infection_Homo sapiens_hsa051321.02074996
66Viral myocarditis_Homo sapiens_hsa054161.00704937
67Basal transcription factors_Homo sapiens_hsa030221.00265370
68B cell receptor signaling pathway_Homo sapiens_hsa046620.99984345
69Epstein-Barr virus infection_Homo sapiens_hsa051690.99837772
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98873587
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98675394
72Colorectal cancer_Homo sapiens_hsa052100.98570337
73Pyrimidine metabolism_Homo sapiens_hsa002400.96586268
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.91925258
75Apoptosis_Homo sapiens_hsa042100.91370195
76Non-small cell lung cancer_Homo sapiens_hsa052230.90942268
77mTOR signaling pathway_Homo sapiens_hsa041500.90592444
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.89953842
79Non-homologous end-joining_Homo sapiens_hsa034500.88685449
80* Pathways in cancer_Homo sapiens_hsa052000.88137201
81Wnt signaling pathway_Homo sapiens_hsa043100.87445878
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85782073
83T cell receptor signaling pathway_Homo sapiens_hsa046600.85046129
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84995970
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84632889
86Primary immunodeficiency_Homo sapiens_hsa053400.84135411
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.84113212
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80379808
89Prostate cancer_Homo sapiens_hsa052150.80117043
90Selenocompound metabolism_Homo sapiens_hsa004500.79972053
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.78547232
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77667269
93Tight junction_Homo sapiens_hsa045300.77000977
94Endocytosis_Homo sapiens_hsa041440.75873055
95Choline metabolism in cancer_Homo sapiens_hsa052310.75250760
96Pertussis_Homo sapiens_hsa051330.74643634
97Shigellosis_Homo sapiens_hsa051310.73295512
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.72886287
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72738047
100Hepatitis B_Homo sapiens_hsa051610.72616690
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72484763
102Toxoplasmosis_Homo sapiens_hsa051450.71613393
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.71288137
104VEGF signaling pathway_Homo sapiens_hsa043700.71161744
105Other glycan degradation_Homo sapiens_hsa005110.69837408
106MAPK signaling pathway_Homo sapiens_hsa040100.69735398
107Platelet activation_Homo sapiens_hsa046110.67820946
108Pancreatic cancer_Homo sapiens_hsa052120.67405786
109* Phospholipase D signaling pathway_Homo sapiens_hsa040720.67048237
110Renal cell carcinoma_Homo sapiens_hsa052110.65583407
111Biosynthesis of amino acids_Homo sapiens_hsa012300.64525424
112Systemic lupus erythematosus_Homo sapiens_hsa053220.63983354
113Oocyte meiosis_Homo sapiens_hsa041140.63452795
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.62965044
115Dorso-ventral axis formation_Homo sapiens_hsa043200.62794983
116ErbB signaling pathway_Homo sapiens_hsa040120.62058389
117Axon guidance_Homo sapiens_hsa043600.61597998
118Pentose phosphate pathway_Homo sapiens_hsa000300.61486674
119Focal adhesion_Homo sapiens_hsa045100.61252207
120* Rap1 signaling pathway_Homo sapiens_hsa040150.60955214
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.60525939
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59646992
123GnRH signaling pathway_Homo sapiens_hsa049120.56825820
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56813115
125Rheumatoid arthritis_Homo sapiens_hsa053230.56082922
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55578692
127ECM-receptor interaction_Homo sapiens_hsa045120.55450317
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55290598
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53281618
130Proteasome_Homo sapiens_hsa030500.51554254
131Measles_Homo sapiens_hsa051620.51511949
132Legionellosis_Homo sapiens_hsa051340.51354299
133HIF-1 signaling pathway_Homo sapiens_hsa040660.49318176
134Influenza A_Homo sapiens_hsa051640.48949021
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48801952
136Lysosome_Homo sapiens_hsa041420.47056042
137Hepatitis C_Homo sapiens_hsa051600.46617147
138Amoebiasis_Homo sapiens_hsa051460.45881329
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45092396
140Asthma_Homo sapiens_hsa053100.43786421
141Collecting duct acid secretion_Homo sapiens_hsa049660.42176077
142Glioma_Homo sapiens_hsa052140.41765928
143FoxO signaling pathway_Homo sapiens_hsa040680.41079302
144Prolactin signaling pathway_Homo sapiens_hsa049170.40974242
145Melanoma_Homo sapiens_hsa052180.40084950
146Type II diabetes mellitus_Homo sapiens_hsa049300.39349434
147Osteoclast differentiation_Homo sapiens_hsa043800.39309900
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.39289836
149* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39025795
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38680566
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.38359827
152Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36335481
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35879767
154Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33929827
155Ras signaling pathway_Homo sapiens_hsa040140.32465672
156Estrogen signaling pathway_Homo sapiens_hsa049150.32073351

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