LPAL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.97229909
2fucose catabolic process (GO:0019317)4.45025577
3L-fucose metabolic process (GO:0042354)4.45025577
4L-fucose catabolic process (GO:0042355)4.45025577
5behavioral response to ethanol (GO:0048149)4.38374535
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.14764879
7tryptophan catabolic process (GO:0006569)3.95044043
8indole-containing compound catabolic process (GO:0042436)3.95044043
9indolalkylamine catabolic process (GO:0046218)3.95044043
10drug catabolic process (GO:0042737)3.90699241
11pyrimidine nucleobase catabolic process (GO:0006208)3.88172693
12nonmotile primary cilium assembly (GO:0035058)3.88130529
13detection of light stimulus involved in visual perception (GO:0050908)3.83875261
14detection of light stimulus involved in sensory perception (GO:0050962)3.83875261
15indolalkylamine metabolic process (GO:0006586)3.82260096
16kynurenine metabolic process (GO:0070189)3.76693690
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.71859863
18regulation of cilium movement (GO:0003352)3.64512054
19exogenous drug catabolic process (GO:0042738)3.64027471
20photoreceptor cell maintenance (GO:0045494)3.57297612
21nucleobase catabolic process (GO:0046113)3.42410957
22protein polyglutamylation (GO:0018095)3.40373108
23response to pheromone (GO:0019236)3.35686002
24cellular biogenic amine catabolic process (GO:0042402)3.32506574
25amine catabolic process (GO:0009310)3.32506574
26gamma-aminobutyric acid transport (GO:0015812)3.30739310
27transmission of nerve impulse (GO:0019226)3.28610647
28water-soluble vitamin biosynthetic process (GO:0042364)3.26477566
29cellular ketone body metabolic process (GO:0046950)3.24426972
30tachykinin receptor signaling pathway (GO:0007217)3.23454230
31axoneme assembly (GO:0035082)3.21160910
32positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.20171697
33piRNA metabolic process (GO:0034587)3.19854689
34oxidative demethylation (GO:0070989)3.14044567
35auditory receptor cell differentiation (GO:0042491)3.10691900
36neuronal action potential (GO:0019228)3.10118191
37somite development (GO:0061053)3.09349052
38tryptophan metabolic process (GO:0006568)3.05444867
39epithelial cilium movement (GO:0003351)3.04993649
40protein localization to cilium (GO:0061512)3.02285012
41ketone body metabolic process (GO:1902224)2.99586544
42DNA deamination (GO:0045006)2.98637478
43adaptation of signaling pathway (GO:0023058)2.97371440
44negative regulation of astrocyte differentiation (GO:0048712)2.95474736
45synaptic transmission, cholinergic (GO:0007271)2.93405630
46S-adenosylmethionine metabolic process (GO:0046500)2.92124880
47positive regulation of sodium ion transmembrane transport (GO:1902307)2.91486708
48negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89879860
49cilium morphogenesis (GO:0060271)2.86052682
50parturition (GO:0007567)2.84835328
51arginine metabolic process (GO:0006525)2.83904739
52aromatic amino acid family catabolic process (GO:0009074)2.80312364
53arginine catabolic process (GO:0006527)2.78035034
54indole-containing compound metabolic process (GO:0042430)2.76769682
55cilium or flagellum-dependent cell motility (GO:0001539)2.76717661
56central nervous system myelination (GO:0022010)2.75970566
57axon ensheathment in central nervous system (GO:0032291)2.75970566
58negative regulation of telomere maintenance (GO:0032205)2.75319841
59DNA methylation involved in gamete generation (GO:0043046)2.73367620
60neural tube formation (GO:0001841)2.70859387
61regulation of microtubule-based movement (GO:0060632)2.69240776
62negative regulation of mast cell activation (GO:0033004)2.67806804
63head development (GO:0060322)2.67664802
64negative regulation of response to food (GO:0032096)2.66552792
65negative regulation of appetite (GO:0032099)2.66552792
66primary amino compound metabolic process (GO:1901160)2.66194489
67nephron epithelium morphogenesis (GO:0072088)2.66116769
68nephron tubule morphogenesis (GO:0072078)2.66116769
69membrane depolarization during action potential (GO:0086010)2.65333569
70preassembly of GPI anchor in ER membrane (GO:0016254)2.62294827
71cilium organization (GO:0044782)2.62243530
72thyroid hormone metabolic process (GO:0042403)2.60338695
73retinal cone cell development (GO:0046549)2.60195009
74platelet dense granule organization (GO:0060155)2.59599283
75regulation of action potential (GO:0098900)2.57913825
76reflex (GO:0060004)2.57443892
77basic amino acid transport (GO:0015802)2.57259072
78cilium movement (GO:0003341)2.55336187
79photoreceptor cell development (GO:0042461)2.54779517
80intraciliary transport (GO:0042073)2.53929308
81neuronal action potential propagation (GO:0019227)2.53496334
82positive regulation of fatty acid transport (GO:2000193)2.53492394
83multicellular organism reproduction (GO:0032504)2.52253477
84cilium assembly (GO:0042384)2.51549871
85negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.50949984
86regulation of glucokinase activity (GO:0033131)2.50638768
87regulation of hexokinase activity (GO:1903299)2.50638768
88detection of mechanical stimulus involved in sensory perception (GO:0050974)2.50633844
89cell proliferation in forebrain (GO:0021846)2.44735805
90positive regulation of oligodendrocyte differentiation (GO:0048714)2.43416547
91benzene-containing compound metabolic process (GO:0042537)2.43245461
92membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43171291
93cAMP catabolic process (GO:0006198)2.41798437
94regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.41520489
95dendritic spine morphogenesis (GO:0060997)2.40270567
96cornea development in camera-type eye (GO:0061303)2.37613731
97serotonin metabolic process (GO:0042428)2.34932836
98C4-dicarboxylate transport (GO:0015740)2.33847751
99aromatic amino acid family metabolic process (GO:0009072)2.32622122
100sulfation (GO:0051923)2.32012776

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.16560105
2ZNF274_21170338_ChIP-Seq_K562_Hela3.11239810
3GBX2_23144817_ChIP-Seq_PC3_Human2.89906752
4VDR_22108803_ChIP-Seq_LS180_Human2.83094316
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75979982
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.56674208
7IGF1R_20145208_ChIP-Seq_DFB_Human2.29201215
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.24485864
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14768558
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.08010412
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07732577
12P300_19829295_ChIP-Seq_ESCs_Human1.87660279
13FLI1_27457419_Chip-Seq_LIVER_Mouse1.83329953
14FUS_26573619_Chip-Seq_HEK293_Human1.82766522
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80080566
16REST_21632747_ChIP-Seq_MESCs_Mouse1.76801914
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74570756
18TAF15_26573619_Chip-Seq_HEK293_Human1.71353072
19BCAT_22108803_ChIP-Seq_LS180_Human1.71234932
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.70546134
21ER_23166858_ChIP-Seq_MCF-7_Human1.65666341
22IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64818643
23CBP_20019798_ChIP-Seq_JUKART_Human1.64818643
24STAT3_23295773_ChIP-Seq_U87_Human1.64675405
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64239278
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62000456
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61407993
28EWS_26573619_Chip-Seq_HEK293_Human1.60714344
29SMAD4_21799915_ChIP-Seq_A2780_Human1.57321164
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55652385
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52575475
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.52183784
33NR3C1_21868756_ChIP-Seq_MCF10A_Human1.51814058
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51207453
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51194605
36TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49164187
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49164187
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46196736
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.44545084
40* TCF4_23295773_ChIP-Seq_U87_Human1.44449216
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43977004
42IRF1_19129219_ChIP-ChIP_H3396_Human1.43971868
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42084774
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38661730
45TP53_22573176_ChIP-Seq_HFKS_Human1.38361862
46AR_25329375_ChIP-Seq_VCAP_Human1.35891916
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33396192
48TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32173742
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32095206
50TCF4_22108803_ChIP-Seq_LS180_Human1.31774184
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31621863
52RNF2_27304074_Chip-Seq_NSC_Mouse1.30578397
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28198986
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.27865338
55SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27837746
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27102579
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26518977
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.26420050
59RUNX2_22187159_ChIP-Seq_PCA_Human1.25610137
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.25389782
61ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25388719
62SOX2_19829295_ChIP-Seq_ESCs_Human1.24959470
63NANOG_19829295_ChIP-Seq_ESCs_Human1.24959470
64NCOR_22424771_ChIP-Seq_293T_Human1.24201439
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.23719359
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.23470465
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23338473
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23128667
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22849289
70AR_21572438_ChIP-Seq_LNCaP_Human1.21653824
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.21543444
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.20787824
73DROSHA_22980978_ChIP-Seq_HELA_Human1.20503357
74SMAD4_21741376_ChIP-Seq_EPCs_Human1.18517504
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.18082611
76FLI1_21867929_ChIP-Seq_TH2_Mouse1.18019010
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.17441095
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16252248
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.16117816
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14837971
81SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13537044
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11893857
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11673341
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09875570
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09393974
86FOXA1_25329375_ChIP-Seq_VCAP_Human1.08939816
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08939816
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.08088248
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07877217
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07849370
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06285725
92P53_22387025_ChIP-Seq_ESCs_Mouse1.05857562
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.04665405
94NOTCH1_21737748_ChIP-Seq_TLL_Human1.01937413
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.01367115
96AR_20517297_ChIP-Seq_VCAP_Human1.00975019
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00930812
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99989196
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.99467589
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98448924

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.52295216
2MP0002653_abnormal_ependyma_morphology2.78311729
3MP0006276_abnormal_autonomic_nervous2.43568668
4MP0003195_calcinosis2.40149200
5MP0001968_abnormal_touch/_nociception2.33895495
6MP0005551_abnormal_eye_electrophysiolog2.31449817
7MP0003646_muscle_fatigue2.28323442
8MP0006292_abnormal_olfactory_placode2.27051925
9MP0002736_abnormal_nociception_after2.20300597
10MP0008877_abnormal_DNA_methylation2.18413326
11MP0000569_abnormal_digit_pigmentation2.11520089
12MP0002102_abnormal_ear_morphology2.02123041
13MP0003880_abnormal_central_pattern1.96575871
14MP0001485_abnormal_pinna_reflex1.93607045
15MP0006072_abnormal_retinal_apoptosis1.87316870
16MP0001984_abnormal_olfaction1.85668389
17MP0003121_genomic_imprinting1.82424211
18MP0002163_abnormal_gland_morphology1.82039350
19MP0009745_abnormal_behavioral_response1.81954758
20MP0005645_abnormal_hypothalamus_physiol1.81505101
21MP0001501_abnormal_sleep_pattern1.79921246
22MP0005646_abnormal_pituitary_gland1.79396356
23MP0004133_heterotaxia1.78090293
24MP0002876_abnormal_thyroid_physiology1.73612746
25MP0001986_abnormal_taste_sensitivity1.73558562
26MP0004142_abnormal_muscle_tone1.72208191
27MP0005360_urolithiasis1.71050667
28MP0005085_abnormal_gallbladder_physiolo1.70038007
29MP0008875_abnormal_xenobiotic_pharmacok1.67065345
30MP0005253_abnormal_eye_physiology1.63450546
31MP0003011_delayed_dark_adaptation1.63307012
32MP0003122_maternal_imprinting1.62813829
33MP0002272_abnormal_nervous_system1.58288302
34MP0002837_dystrophic_cardiac_calcinosis1.55631514
35MP0003136_yellow_coat_color1.53997109
36MP0000631_abnormal_neuroendocrine_gland1.53006346
37MP0001486_abnormal_startle_reflex1.52060438
38MP0004742_abnormal_vestibular_system1.50574787
39MP0004885_abnormal_endolymph1.45097793
40MP0003252_abnormal_bile_duct1.44951453
41MP0002138_abnormal_hepatobiliary_system1.41900190
42MP0008872_abnormal_physiological_respon1.40988847
43MP0002928_abnormal_bile_duct1.40769310
44MP0002909_abnormal_adrenal_gland1.39760237
45MP0008789_abnormal_olfactory_epithelium1.39534605
46MP0005423_abnormal_somatic_nervous1.37960078
47MP0005379_endocrine/exocrine_gland_phen1.37418993
48MP0001529_abnormal_vocalization1.37175668
49MP0002572_abnormal_emotion/affect_behav1.36973795
50MP0002557_abnormal_social/conspecific_i1.34667510
51MP0009046_muscle_twitch1.34067771
52MP0003879_abnormal_hair_cell1.31737119
53MP0003635_abnormal_synaptic_transmissio1.31635215
54MP0001970_abnormal_pain_threshold1.31390399
55MP0003123_paternal_imprinting1.30819193
56MP0000427_abnormal_hair_cycle1.28951725
57MP0004145_abnormal_muscle_electrophysio1.28480078
58MP0000778_abnormal_nervous_system1.28392032
59MP0004043_abnormal_pH_regulation1.25781176
60MP0002733_abnormal_thermal_nociception1.25306453
61MP0005377_hearing/vestibular/ear_phenot1.22433147
62MP0003878_abnormal_ear_physiology1.22433147
63MP0010386_abnormal_urinary_bladder1.22416906
64MP0002234_abnormal_pharynx_morphology1.20913264
65MP0002735_abnormal_chemical_nociception1.18087325
66MP0002063_abnormal_learning/memory/cond1.15737508
67MP0002064_seizures1.13842832
68MP0002067_abnormal_sensory_capabilities1.13492583
69MP0002734_abnormal_mechanical_nocicepti1.13319855
70MP0005195_abnormal_posterior_eye1.11072079
71MP0002184_abnormal_innervation1.10854653
72MP0000026_abnormal_inner_ear1.08544355
73MP0000372_irregular_coat_pigmentation1.08426473
74MP0000230_abnormal_systemic_arterial1.07606674
75MP0002638_abnormal_pupillary_reflex1.07076110
76MP0001963_abnormal_hearing_physiology1.05044779
77MP0002752_abnormal_somatic_nervous1.04402461
78MP0004924_abnormal_behavior1.01354561
79MP0005386_behavior/neurological_phenoty1.01354561
80MP0005174_abnormal_tail_pigmentation0.98617154
81MP0005499_abnormal_olfactory_system0.98407342
82MP0005394_taste/olfaction_phenotype0.98407342
83MP0002822_catalepsy0.95496746
84MP0005365_abnormal_bile_salt0.94485805
85MP0005084_abnormal_gallbladder_morpholo0.93791477
86MP0005167_abnormal_blood-brain_barrier0.92818130
87MP0001440_abnormal_grooming_behavior0.91633370
88MP0002938_white_spotting0.90160500
89MP0002160_abnormal_reproductive_system0.86105077
90MP0005332_abnormal_amino_acid0.85491450
91MP0000955_abnormal_spinal_cord0.85026626
92MP0005389_reproductive_system_phenotype0.84710056
93MP0001905_abnormal_dopamine_level0.83710940
94MP0002882_abnormal_neuron_morphology0.82970623
95MP0003119_abnormal_digestive_system0.81898292
96MP0004859_abnormal_synaptic_plasticity0.80947948
97MP0004147_increased_porphyrin_level0.79838766
98MP0001324_abnormal_eye_pigmentation0.79668854
99MP0002229_neurodegeneration0.79326303
100MP0002693_abnormal_pancreas_physiology0.78014369

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.40218933
2Molar tooth sign on MRI (HP:0002419)4.40218933
3Pancreatic fibrosis (HP:0100732)4.19274849
4Pancreatic cysts (HP:0001737)4.15571673
5Nephronophthisis (HP:0000090)3.82211547
6True hermaphroditism (HP:0010459)3.78077281
7Medial flaring of the eyebrow (HP:0010747)3.64715396
8Abnormality of the renal cortex (HP:0011035)3.57336257
9Congenital stationary night blindness (HP:0007642)3.49105467
10Abnormality of the renal medulla (HP:0100957)3.39901921
11Chronic hepatic failure (HP:0100626)3.36734498
12Type II lissencephaly (HP:0007260)3.23588351
13Abolished electroretinogram (ERG) (HP:0000550)3.11062541
14Gait imbalance (HP:0002141)3.09936647
15Attenuation of retinal blood vessels (HP:0007843)3.05970845
16Hyperventilation (HP:0002883)3.04975183
17Congenital primary aphakia (HP:0007707)2.94925586
18Cystic liver disease (HP:0006706)2.88684728
19Renal cortical cysts (HP:0000803)2.88580940
20Abnormal rod and cone electroretinograms (HP:0008323)2.83206456
21Abnormal biliary tract physiology (HP:0012439)2.80086727
22Bile duct proliferation (HP:0001408)2.80086727
23Nephrogenic diabetes insipidus (HP:0009806)2.77392809
24Polydipsia (HP:0001959)2.68091240
25Abnormal drinking behavior (HP:0030082)2.68091240
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.66846026
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.63159161
28Absent/shortened dynein arms (HP:0200106)2.63159161
29Neoplasm of the adrenal cortex (HP:0100641)2.57444154
30Tubular atrophy (HP:0000092)2.54103956
31Genital tract atresia (HP:0001827)2.50731336
32Bony spicule pigmentary retinopathy (HP:0007737)2.47940023
33Vaginal atresia (HP:0000148)2.43789554
34Sclerocornea (HP:0000647)2.36446706
35Genetic anticipation (HP:0003743)2.35039026
36Agitation (HP:0000713)2.29442953
37Febrile seizures (HP:0002373)2.28669612
38Progressive cerebellar ataxia (HP:0002073)2.28347610
39Gaze-evoked nystagmus (HP:0000640)2.27552919
40Abnormal respiratory epithelium morphology (HP:0012253)2.27482654
41Abnormal respiratory motile cilium morphology (HP:0005938)2.27482654
42Anencephaly (HP:0002323)2.25969448
43Decreased central vision (HP:0007663)2.22766718
44Increased corneal curvature (HP:0100692)2.22249775
45Keratoconus (HP:0000563)2.22249775
46Congenital hepatic fibrosis (HP:0002612)2.21893895
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.19980942
48Poor coordination (HP:0002370)2.19138695
49Optic nerve hypoplasia (HP:0000609)2.16532319
50Decreased circulating renin level (HP:0003351)2.16249959
51Inability to walk (HP:0002540)2.14520995
52Thyroid-stimulating hormone excess (HP:0002925)2.14085836
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.13001911
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12282480
55Rib fusion (HP:0000902)2.12019450
56Polyphagia (HP:0002591)2.10506635
57Postaxial foot polydactyly (HP:0001830)2.10211232
58Stomach cancer (HP:0012126)2.10060162
59Protruding tongue (HP:0010808)2.08455310
60Constricted visual fields (HP:0001133)2.06357115
61Polyuria (HP:0000103)2.06174147
62Lissencephaly (HP:0001339)2.05310775
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.02817535
64Fair hair (HP:0002286)2.01269870
65Retinitis pigmentosa (HP:0000510)2.00497558
66Cerebellar dysplasia (HP:0007033)2.00473268
67Pendular nystagmus (HP:0012043)1.99245615
68Decreased electroretinogram (ERG) amplitude (HP:0000654)1.98421529
69Thyroiditis (HP:0100646)1.97731676
70Pachygyria (HP:0001302)1.97218100
71Abnormal ciliary motility (HP:0012262)1.94401072
72Hyperglycinemia (HP:0002154)1.92811080
73Retinal dysplasia (HP:0007973)1.92127167
74Abnormality of alanine metabolism (HP:0010916)1.91807886
75Hyperalaninemia (HP:0003348)1.91807886
76Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91807886
77Asplenia (HP:0001746)1.91798350
78Ketosis (HP:0001946)1.91357257
79Broad-based gait (HP:0002136)1.90308543
80Postaxial hand polydactyly (HP:0001162)1.88565936
81Short foot (HP:0001773)1.85757258
82Abnormal respiratory motile cilium physiology (HP:0012261)1.84205087
83Metaphyseal dysplasia (HP:0100255)1.83976230
84Enlarged kidneys (HP:0000105)1.82205889
85Clumsiness (HP:0002312)1.81214008
86Growth hormone deficiency (HP:0000824)1.81141770
87Intestinal atresia (HP:0011100)1.80382407
88Narrow forehead (HP:0000341)1.78203287
89Male pseudohermaphroditism (HP:0000037)1.78196472
90Focal seizures (HP:0007359)1.77243144
91Specific learning disability (HP:0001328)1.76887227
92Colon cancer (HP:0003003)1.75596044
93Hip dysplasia (HP:0001385)1.75335823
94Left ventricular hypertrophy (HP:0001712)1.74311287
95Furrowed tongue (HP:0000221)1.72310994
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.71116123
97Hemiparesis (HP:0001269)1.71098110
98Prominent nasal bridge (HP:0000426)1.69602901
99Methylmalonic aciduria (HP:0012120)1.69449971
100Absent speech (HP:0001344)1.69073890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.51199068
2BMPR1B3.50203272
3WNK33.02549590
4ADRBK22.89595880
5TAOK32.85345310
6CASK2.50874506
7PINK12.43559301
8GRK12.25259447
9MAP4K22.20314402
10WNK42.13027530
11ZAK2.09391421
12MAP3K42.05729686
13MAPK131.99785942
14NUAK11.99440569
15INSRR1.98942320
16MUSK1.94582618
17TXK1.74788104
18MAP2K71.64454109
19STK391.50725113
20SIK21.45012915
21NTRK31.36712133
22DYRK21.35893002
23BCKDK1.31937436
24MARK11.26538692
25BCR1.21297074
26PRKCG1.15637821
27TNIK1.14741490
28PTK2B1.10553044
29ADRBK11.09774588
30NTRK21.08826713
31TLK11.07620687
32OXSR11.05521090
33PAK31.04010309
34ACVR1B0.97637294
35DAPK20.97579982
36TRIM280.94396705
37TNK20.92859037
38TIE10.90872800
39AKT30.86341148
40PRKCE0.83597713
41MAP2K60.83305802
42EPHA40.82392285
43PRKCQ0.80618978
44STK38L0.79070745
45MKNK20.78245757
46CAMKK20.76665593
47PLK20.75285893
48PIK3CA0.72657036
49CSNK1G20.71094417
50TEC0.65930475
51MAP2K20.64784125
52EPHA30.64454378
53FGFR20.64392554
54CAMK10.64081396
55SGK2230.63561681
56SGK4940.63561681
57STK110.63468750
58PRKCH0.59901311
59CSNK1G10.57826267
60PRKACA0.56291599
61CSNK1G30.56170399
62ITK0.55340265
63PHKG20.54992141
64PHKG10.54992141
65DYRK1A0.54986672
66PNCK0.54790653
67ERBB20.53462786
68SGK20.52561739
69MAPK150.52005998
70CAMK2A0.51527769
71CSNK1A1L0.51045489
72STK380.48684633
73ERBB30.48359647
74OBSCN0.43403509
75CAMK1G0.42843962
76PRKCZ0.42553318
77PRKCA0.41873498
78MINK10.41861665
79PRKD30.41311318
80CAMK1D0.40831992
81SYK0.40751173
82PRKCI0.40738541
83CSNK1A10.40516779
84PRKAA10.40220024
85PRKAA20.39201124
86CDK50.38068143
87MAPKAPK30.37599748
88CAMK40.37280142
89MAP2K40.36938081
90MARK30.36461730
91PKN10.36302010
92IRAK10.35608357
93KIT0.33734121
94CAMKK10.32931515
95GRK70.32479157
96STK30.32357462
97PLK40.32116108
98PIK3CG0.31768715
99FER0.31012403
100CSNK1D0.29554404

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005912.91566601
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.61271289
3Nicotine addiction_Homo sapiens_hsa050332.59566145
4Phototransduction_Homo sapiens_hsa047442.52530550
5Caffeine metabolism_Homo sapiens_hsa002322.42848859
6Butanoate metabolism_Homo sapiens_hsa006502.42154154
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.39183777
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35611368
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30716843
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.22691129
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.16406716
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11667889
13Retinol metabolism_Homo sapiens_hsa008302.05431062
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02708302
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.01902332
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96625576
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93531224
18Tryptophan metabolism_Homo sapiens_hsa003801.91834679
19Chemical carcinogenesis_Homo sapiens_hsa052041.89930999
20Nitrogen metabolism_Homo sapiens_hsa009101.70110083
21ABC transporters_Homo sapiens_hsa020101.67148978
22Morphine addiction_Homo sapiens_hsa050321.57664314
23Ether lipid metabolism_Homo sapiens_hsa005651.57345388
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.55242245
25Arachidonic acid metabolism_Homo sapiens_hsa005901.51913010
26Olfactory transduction_Homo sapiens_hsa047401.50175220
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49950902
28Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40632988
29Propanoate metabolism_Homo sapiens_hsa006401.40096168
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.39027194
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38311896
32Oxidative phosphorylation_Homo sapiens_hsa001901.35945892
33Peroxisome_Homo sapiens_hsa041461.31279007
34Taste transduction_Homo sapiens_hsa047421.30505796
35Protein export_Homo sapiens_hsa030601.30076926
36GABAergic synapse_Homo sapiens_hsa047271.23259800
37Selenocompound metabolism_Homo sapiens_hsa004501.23077465
38Circadian entrainment_Homo sapiens_hsa047131.19158301
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16380359
40Homologous recombination_Homo sapiens_hsa034401.16021347
41Insulin secretion_Homo sapiens_hsa049111.15781499
42Fanconi anemia pathway_Homo sapiens_hsa034601.13181966
43Serotonergic synapse_Homo sapiens_hsa047261.12027354
44Glutamatergic synapse_Homo sapiens_hsa047241.08222105
45beta-Alanine metabolism_Homo sapiens_hsa004101.07555551
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00319677
47Fatty acid degradation_Homo sapiens_hsa000710.98747759
48Glycerolipid metabolism_Homo sapiens_hsa005610.94300590
49Histidine metabolism_Homo sapiens_hsa003400.94270092
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92804513
51Parkinsons disease_Homo sapiens_hsa050120.92281450
52Cardiac muscle contraction_Homo sapiens_hsa042600.89155389
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88480319
54Complement and coagulation cascades_Homo sapiens_hsa046100.85842162
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80357950
56Primary immunodeficiency_Homo sapiens_hsa053400.79358328
57Basal transcription factors_Homo sapiens_hsa030220.78725915
58Regulation of autophagy_Homo sapiens_hsa041400.76787753
59Fat digestion and absorption_Homo sapiens_hsa049750.73572877
60Steroid biosynthesis_Homo sapiens_hsa001000.72839669
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70428703
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.69557901
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68367045
64Dopaminergic synapse_Homo sapiens_hsa047280.67856546
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.66943358
66Salivary secretion_Homo sapiens_hsa049700.66153349
67RNA polymerase_Homo sapiens_hsa030200.64999362
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64689838
69Ovarian steroidogenesis_Homo sapiens_hsa049130.61385787
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61072015
71Calcium signaling pathway_Homo sapiens_hsa040200.60974129
72Metabolic pathways_Homo sapiens_hsa011000.60723260
73Dorso-ventral axis formation_Homo sapiens_hsa043200.57989758
74Alzheimers disease_Homo sapiens_hsa050100.55940357
75Huntingtons disease_Homo sapiens_hsa050160.55668985
76Starch and sucrose metabolism_Homo sapiens_hsa005000.53585480
77Bile secretion_Homo sapiens_hsa049760.53486581
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.53245662
79Cholinergic synapse_Homo sapiens_hsa047250.52928549
80Collecting duct acid secretion_Homo sapiens_hsa049660.52574165
81Arginine and proline metabolism_Homo sapiens_hsa003300.47980870
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.47250011
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.45684743
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.45380832
85Long-term depression_Homo sapiens_hsa047300.44180285
86Fatty acid metabolism_Homo sapiens_hsa012120.43883167
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43491535
88Tyrosine metabolism_Homo sapiens_hsa003500.43111281
89Renin secretion_Homo sapiens_hsa049240.41638230
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41313009
91Mineral absorption_Homo sapiens_hsa049780.40369371
92Sulfur metabolism_Homo sapiens_hsa009200.39850796
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.38989713
94Cocaine addiction_Homo sapiens_hsa050300.37071779
95cAMP signaling pathway_Homo sapiens_hsa040240.35089008
96One carbon pool by folate_Homo sapiens_hsa006700.34992806
97RNA degradation_Homo sapiens_hsa030180.33971590
98Hedgehog signaling pathway_Homo sapiens_hsa043400.32291211
99Oxytocin signaling pathway_Homo sapiens_hsa049210.31952874
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31592085

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