LOXL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)8.34719190
2collagen fibril organization (GO:0030199)7.63134652
3chondrocyte proliferation (GO:0035988)6.75466605
4keratan sulfate catabolic process (GO:0042340)6.18894357
5chondrocyte development (GO:0002063)6.07056417
6cell aggregation (GO:0098743)5.88814741
7cartilage condensation (GO:0001502)5.88814741
8positive regulation of extracellular matrix organization (GO:1903055)5.80985568
9skin morphogenesis (GO:0043589)5.51414064
10replacement ossification (GO:0036075)5.23915153
11endochondral ossification (GO:0001958)5.23915153
12regulation of plasminogen activation (GO:0010755)5.13822739
13collagen catabolic process (GO:0030574)5.10210873
14endodermal cell differentiation (GO:0035987)5.09778886
15protein heterotrimerization (GO:0070208)5.09733888
16collagen metabolic process (GO:0032963)5.04526419
17negative regulation of execution phase of apoptosis (GO:1900118)5.01609106
18positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003574.96316350
19iron ion import (GO:0097286)4.91054300
20multicellular organismal macromolecule metabolic process (GO:0044259)4.70176588
21multicellular organismal catabolic process (GO:0044243)4.65109086
22multicellular organismal metabolic process (GO:0044236)4.45725199
23glycerophospholipid catabolic process (GO:0046475)4.45227691
24cell adhesion mediated by integrin (GO:0033627)4.44247622
25extracellular matrix disassembly (GO:0022617)4.42663669
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.40700587
27negative regulation of complement activation (GO:0045916)4.19018086
28regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.16309532
29notochord development (GO:0030903)4.15697676
30peptidyl-proline hydroxylation (GO:0019511)4.15560974
31regulation of execution phase of apoptosis (GO:1900117)4.12783210
32regulation of extracellular matrix disassembly (GO:0010715)4.04460687
33peptide hormone processing (GO:0016486)4.02965549
34type B pancreatic cell proliferation (GO:0044342)3.91601224
35positive regulation of gluconeogenesis (GO:0045722)3.89860608
36cartilage development (GO:0051216)3.88761303
37endothelial cell morphogenesis (GO:0001886)3.86945509
38peptidyl-glutamic acid carboxylation (GO:0017187)3.83346193
39protein carboxylation (GO:0018214)3.83346193
40negative regulation of protein activation cascade (GO:2000258)3.78952652
41macroautophagy (GO:0016236)3.78173309
42bone trabecula formation (GO:0060346)3.70443812
43positive regulation of endothelial cell apoptotic process (GO:2000353)3.69099376
44L-phenylalanine metabolic process (GO:0006558)3.66022078
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66022078
46inositol phosphate-mediated signaling (GO:0048016)3.61783985
47negative regulation of fatty acid transport (GO:2000192)3.58165483
48protein hydroxylation (GO:0018126)3.58104448
49regulation of type B pancreatic cell apoptotic process (GO:2000674)3.55052934
50positive regulation of cartilage development (GO:0061036)3.54041305
51epithelial cell-cell adhesion (GO:0090136)3.53114963
52epithelial cell fate commitment (GO:0072148)3.51265137
53chondroitin sulfate biosynthetic process (GO:0030206)3.51037155
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49743083
55hypotonic response (GO:0006971)3.45844515
56extracellular matrix organization (GO:0030198)3.42332254
57proteoglycan metabolic process (GO:0006029)3.41175011
58extracellular structure organization (GO:0043062)3.40905642
59retinol metabolic process (GO:0042572)3.39169700
60embryonic skeletal joint morphogenesis (GO:0060272)3.37531197
61protein retention in ER lumen (GO:0006621)3.37502754
62regulation of fibrinolysis (GO:0051917)3.35014230
63response to magnesium ion (GO:0032026)3.34030929
64Golgi transport vesicle coating (GO:0048200)3.33596603
65COPI coating of Golgi vesicle (GO:0048205)3.33596603
66positive regulation of calcium ion import (GO:0090280)3.32961998
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.30711865
68L-phenylalanine catabolic process (GO:0006559)3.30711865
69negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.28033191
70regulation of extracellular matrix organization (GO:1903053)3.25804631
71positive regulation of histone H3-K4 methylation (GO:0051571)3.24189515
72regulation of cartilage development (GO:0061035)3.24151033
73insulin secretion (GO:0030073)3.18226101
74cellular response to vitamin (GO:0071295)3.17064464
75negative regulation of chondrocyte differentiation (GO:0032331)3.17051215
76cellular response to vitamin D (GO:0071305)3.16201577
77skeletal system development (GO:0001501)3.16110308
78ossification (GO:0001503)3.15923864
79COPII vesicle coating (GO:0048208)3.15432205
80nitric oxide biosynthetic process (GO:0006809)3.15315803
81apoptotic cell clearance (GO:0043277)3.13955658
82positive regulation of osteoblast proliferation (GO:0033690)3.13942963
83tooth mineralization (GO:0034505)3.12446433
84L-alpha-amino acid transmembrane transport (GO:1902475)3.11300690
854-hydroxyproline metabolic process (GO:0019471)3.10211555
86protein localization to cell surface (GO:0034394)3.09260830
87regulation of chondrocyte differentiation (GO:0032330)3.08197232
88plasma membrane repair (GO:0001778)3.06968709
89substrate-dependent cell migration (GO:0006929)3.06729566
90connective tissue development (GO:0061448)3.06173883
91positive regulation of insulin secretion (GO:0032024)3.05080093
92wound healing, spreading of epidermal cells (GO:0035313)3.03861510
93negative regulation of fibrinolysis (GO:0051918)3.03427206
94cell-substrate junction assembly (GO:0007044)3.01728147
95negative regulation of humoral immune response (GO:0002921)2.98125645
96limb bud formation (GO:0060174)2.97631950
97positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.92516671
98hemidesmosome assembly (GO:0031581)2.89787517
99negative regulation of cartilage development (GO:0061037)2.89585767
100keratan sulfate biosynthetic process (GO:0018146)2.89281518
101hippo signaling (GO:0035329)2.89194204
102regulation of lipoprotein metabolic process (GO:0050746)2.89029276
103mesodermal cell differentiation (GO:0048333)2.88292186
104positive regulation of chondrocyte differentiation (GO:0032332)2.87674715
105epoxygenase P450 pathway (GO:0019373)2.86715399
106tonic smooth muscle contraction (GO:0014820)2.85593739
107extracellular negative regulation of signal transduction (GO:1900116)2.84963141
108extracellular regulation of signal transduction (GO:1900115)2.84963141
109positive regulation of hormone biosynthetic process (GO:0046886)2.84670813
110cellular glucuronidation (GO:0052695)2.83116622
111response to gravity (GO:0009629)2.80770584
112neuron projection extension involved in neuron projection guidance (GO:1902284)2.80632886
113axon extension involved in axon guidance (GO:0048846)2.80632886
114regulation of phospholipase A2 activity (GO:0032429)2.79761170
115sequestering of extracellular ligand from receptor (GO:0035581)2.79051415
116basement membrane organization (GO:0071711)2.78857607
117sphingomyelin metabolic process (GO:0006684)2.77943390
118lens fiber cell development (GO:0070307)2.75168735
119glycosaminoglycan biosynthetic process (GO:0006024)2.74828163
120embryonic viscerocranium morphogenesis (GO:0048703)2.74236822
121regulation of Rac protein signal transduction (GO:0035020)2.74214325
122dermatan sulfate biosynthetic process (GO:0030208)2.73516135
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.73234972
124cellular ketone body metabolic process (GO:0046950)2.69809033
125adherens junction assembly (GO:0034333)2.69579089
126regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.69477679
127aminoglycan biosynthetic process (GO:0006023)2.68784227
128chondrocyte differentiation (GO:0002062)2.67731540
129positive regulation of blood vessel endothelial cell migration (GO:0043536)2.65695688
130regulation of integrin-mediated signaling pathway (GO:2001044)2.64526382
131regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.64509226
132wound healing, spreading of cells (GO:0044319)2.63566755
133artery smooth muscle contraction (GO:0014824)2.62966573
134positive regulation of p38MAPK cascade (GO:1900745)2.62137862
135S-adenosylmethionine metabolic process (GO:0046500)2.61428891
136cellular zinc ion homeostasis (GO:0006882)2.60298931
137myelin maintenance (GO:0043217)2.60142276
138positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.59877800
139detection of calcium ion (GO:0005513)2.59029670
140heparin biosynthetic process (GO:0030210)2.57905303
141heparin metabolic process (GO:0030202)2.57905303
142mesenchymal-epithelial cell signaling (GO:0060638)2.57327625
143endocrine pancreas development (GO:0031018)2.57217125
144peptide hormone secretion (GO:0030072)2.57065954
145activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.56731774
146intestinal cholesterol absorption (GO:0030299)2.56346870
147negative regulation of adherens junction organization (GO:1903392)2.55206814
148negative regulation of focal adhesion assembly (GO:0051895)2.55206814
149negative regulation of cell junction assembly (GO:1901889)2.55206814
150regulation of tight junction assembly (GO:2000810)2.54072305
151nodal signaling pathway (GO:0038092)2.53523882
152keratan sulfate metabolic process (GO:0042339)2.53415341
153regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.51524618
154peptide secretion (GO:0002790)2.51385177
155pteridine-containing compound biosynthetic process (GO:0042559)2.47623513
156regulation of metalloenzyme activity (GO:0048552)2.47521312
157regulation of transforming growth factor beta1 production (GO:0032908)2.47472878
158potassium ion export (GO:0071435)2.47117565
159glomerular basement membrane development (GO:0032836)2.46991433
160signal peptide processing (GO:0006465)2.45006261
161regulation of autophagic vacuole assembly (GO:2000785)2.44683027
162early endosome to late endosome transport (GO:0045022)2.40964482
163auditory receptor cell differentiation (GO:0042491)2.39992092
164regulation of calcium ion import (GO:0090279)2.39809529
165regulation of gonadotropin secretion (GO:0032276)2.39336862
166response to starvation (GO:0042594)2.38644696
167positive regulation of macroautophagy (GO:0016239)2.37600072
168Golgi to endosome transport (GO:0006895)2.37592152
169endosome to pigment granule transport (GO:0043485)2.37265150
170endosome to melanosome transport (GO:0035646)2.37265150
171regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.35313381
172beta-amyloid metabolic process (GO:0050435)2.35138383
173phospholipid catabolic process (GO:0009395)2.35054524
174ethanol oxidation (GO:0006069)2.33087507
175primary alcohol metabolic process (GO:0034308)2.32610725
176ketone body metabolic process (GO:1902224)2.31347873
177positive regulation of transforming growth factor beta production (GO:0071636)2.30764078
178negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30371455
179phosphorylated carbohydrate dephosphorylation (GO:0046838)2.29133568
180inositol phosphate dephosphorylation (GO:0046855)2.29133568
181water-soluble vitamin biosynthetic process (GO:0042364)2.28452886
182positive regulation of peptide hormone secretion (GO:0090277)2.27735133
183respiratory chain complex IV assembly (GO:0008535)2.26393341

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.69538785
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.65209853
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.11483158
4CLOCK_20551151_ChIP-Seq_293T_Human3.35960410
5RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.27348000
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.19435711
7HIF1A_21447827_ChIP-Seq_MCF-7_Human3.03889173
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.88022064
9ESR1_21235772_ChIP-Seq_MCF-7_Human2.80481567
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.72113806
11* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.68181245
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.53456438
13CJUN_26792858_Chip-Seq_BT549_Human2.48326635
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.46751679
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.44606014
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.38691132
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.23739452
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21897651
19CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.19464306
20BRD4_25478319_ChIP-Seq_HGPS_Human2.16311409
21* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.13472516
22* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.13472516
23GBX2_23144817_ChIP-Seq_PC3_Human2.12441825
24ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.98601782
25NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.96754365
26NRF2_20460467_ChIP-Seq_MEFs_Mouse1.96754365
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91367833
28* ATF3_27146783_Chip-Seq_COLON_Human1.90767390
29ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.86524338
30ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.86004232
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.85773578
32JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.77878275
33PPAR_26484153_Chip-Seq_NCI-H1993_Human1.74793479
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73044244
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.72192854
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.72108584
37JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71132667
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70844681
39* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.68733284
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63411685
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61516083
42WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60644270
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.60528076
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.58879243
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55965624
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.52074748
47* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52061422
48* SOX2_20726797_ChIP-Seq_SW620_Human1.50030543
49EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.49066614
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48995652
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.48475837
52UBF1/2_26484160_Chip-Seq_HMECs_Human1.46577763
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.46048926
54SMC1_22415368_ChIP-Seq_MEFs_Mouse1.45639983
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43439874
56AR_21909140_ChIP-Seq_LNCAP_Human1.41979212
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41006588
58TP53_22127205_ChIP-Seq_IMR90_Human1.40381203
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.39892423
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39016425
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36944353
62* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34840791
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34184206
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34170031
65TP53_16413492_ChIP-PET_HCT116_Human1.33096511
66CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32288157
67BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.30554391
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.30365617
69* FOXA2_19822575_ChIP-Seq_HepG2_Human1.29791064
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29317863
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.28028140
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27465332
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27321703
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27281305
75* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26393228
76FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26215469
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25758050
78AR_21572438_ChIP-Seq_LNCaP_Human1.24990981
79NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24570799
80TP53_18474530_ChIP-ChIP_U2OS_Human1.24234124
81* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22932483
82* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22662234
83HTT_18923047_ChIP-ChIP_STHdh_Human1.22474049
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22413210
85NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21983472
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21902910
87SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21632483
88RACK7_27058665_Chip-Seq_MCF-7_Human1.21035638
89* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20546166
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20198788
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.18694017
92POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17091233
93SMAD4_21799915_ChIP-Seq_A2780_Human1.17067499
94* TBX20_22080862_ChIP-Seq_HEART_Mouse1.16304557
95* TBX20_22328084_ChIP-Seq_HEART_Mouse1.16304557
96PPARA_22158963_ChIP-Seq_LIVER_Mouse1.14645345
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.13909855
98* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13287042
99* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12751320
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.10953900
101* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09319613
102ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08846306
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07185603
104* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.06831671
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.06568283
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.06187627
107SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05934356
108FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.05796940
109FOXA1_25552417_ChIP-Seq_VCAP_Human1.05581839
110STAT3_18555785_Chip-Seq_ESCs_Mouse1.05231070
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04773729
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04542597
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.04338215
114MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.04146544
115GATA3_24758297_ChIP-Seq_MCF-7_Human1.03908073
116NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03898550
117P53_22387025_ChIP-Seq_ESCs_Mouse1.03081769
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.02856935
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02816302
120EED_16625203_ChIP-ChIP_MESCs_Mouse1.02543131
121CDX2_22108803_ChIP-Seq_LS180_Human1.02147274
122CMYC_18555785_Chip-Seq_ESCs_Mouse1.02020951
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.01731535
124* TP53_23651856_ChIP-Seq_MEFs_Mouse1.00692646
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00551137
126STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00385524
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00131765
128SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99939956
129KLF5_25053715_ChIP-Seq_YYC3_Human0.99855973
130PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99809318
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99550560
132SMAD3_21741376_ChIP-Seq_EPCs_Human0.99291598
133NFE2_27457419_Chip-Seq_LIVER_Mouse0.98980280
134TP53_20018659_ChIP-ChIP_R1E_Mouse0.97540924
135ZNF263_19887448_ChIP-Seq_K562_Human0.97180255
136ARNT_22903824_ChIP-Seq_MCF-7_Human0.95679859
137TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95395884
138TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95167015
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93849833
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93745827
141STAT3_23295773_ChIP-Seq_U87_Human0.93617518
142CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92334422
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91771235
144NMYC_18555785_Chip-Seq_ESCs_Mouse0.91535237
145GATA4_25053715_ChIP-Seq_YYC3_Human0.91090672
146E2F1_18555785_Chip-Seq_ESCs_Mouse0.90951367
147SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90882932
148SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90829765
149TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90628162
150RXR_22108803_ChIP-Seq_LS180_Human0.89442100
151KDM2B_26808549_Chip-Seq_K562_Human0.88898709
152BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88709222
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88702303
154PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88185410
155AHR_22903824_ChIP-Seq_MCF-7_Human0.87900614
156SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.87631911
157BCAT_22108803_ChIP-Seq_LS180_Human0.87627856
158OCT4_18555785_Chip-Seq_ESCs_Mouse0.87010649
159SA1_22415368_ChIP-Seq_MEFs_Mouse0.86664132
160TP63_23658742_ChIP-Seq_EP156T_Human0.85519834
161RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84636810
162GATA1_22025678_ChIP-Seq_K562_Human0.83520273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.20702291
2MP0005503_abnormal_tendon_morphology5.11959738
3MP0005275_abnormal_skin_tensile4.23012085
4MP0002837_dystrophic_cardiac_calcinosis4.20231385
5MP0002139_abnormal_hepatobiliary_system3.99785349
6MP0003705_abnormal_hypodermis_morpholog3.91457368
7MP0005379_endocrine/exocrine_gland_phen3.53048240
8MP0003279_aneurysm3.01089803
9MP0002933_joint_inflammation2.99651440
10MP0002909_abnormal_adrenal_gland2.93860388
11MP0009384_cardiac_valve_regurgitation2.89099012
12MP0004134_abnormal_chest_morphology2.85367404
13MP0002163_abnormal_gland_morphology2.82133675
14MP0002254_reproductive_system_inflammat2.74914455
15MP0002282_abnormal_trachea_morphology2.67560418
16MP0009250_abnormal_appendicular_skeleto2.63948342
17MP0000163_abnormal_cartilage_morphology2.49519048
18MP0005623_abnormal_meninges_morphology2.44352215
19MP0010386_abnormal_urinary_bladder2.42731380
20MP0002896_abnormal_bone_mineralization2.38147589
21MP0001958_emphysema2.34428268
22MP0003283_abnormal_digestive_organ2.33960968
23MP0001542_abnormal_bone_strength2.32031015
24MP0005023_abnormal_wound_healing2.27265373
25MP0005508_abnormal_skeleton_morphology2.26216666
26MP0001944_abnormal_pancreas_morphology2.25777609
27MP0003566_abnormal_cell_adhesion2.20267452
28MP0004272_abnormal_basement_membrane2.18928974
29MP0002115_abnormal_skeleton_extremities2.18879498
30MP0000003_abnormal_adipose_tissue2.14555286
31MP0010352_gastrointestinal_tract_polyps2.11700840
32MP0001299_abnormal_eye_distance/2.04502411
33MP0003091_abnormal_cell_migration1.97428799
34MP0001756_abnormal_urination1.92115601
35MP0002113_abnormal_skeleton_development1.85696708
36MP0009780_abnormal_chondrocyte_physiolo1.81449776
37MP0005257_abnormal_intraocular_pressure1.81355204
38MP0002060_abnormal_skin_morphology1.79661841
39MP0002089_abnormal_postnatal_growth/wei1.72413051
40MP0005390_skeleton_phenotype1.71962836
41MP0002693_abnormal_pancreas_physiology1.67964004
42MP0002108_abnormal_muscle_morphology1.67789767
43MP0003172_abnormal_lysosome_physiology1.66591118
44MP0010329_abnormal_lipoprotein_level1.64937135
45MP0010030_abnormal_orbit_morphology1.61613425
46MP0005365_abnormal_bile_salt1.55683374
47MP0001533_abnormal_skeleton_physiology1.54150159
48MP0005248_abnormal_Harderian_gland1.52666791
49MP0005645_abnormal_hypothalamus_physiol1.52265633
50MP0002876_abnormal_thyroid_physiology1.50986188
51MP0005084_abnormal_gallbladder_morpholo1.50229487
52MP0001243_abnormal_dermal_layer1.49383518
53MP0004019_abnormal_vitamin_homeostasis1.49310312
54MP0000751_myopathy1.49037316
55MP0000762_abnormal_tongue_morphology1.41933635
56MP0002877_abnormal_melanocyte_morpholog1.40836773
57MP0003195_calcinosis1.38579533
58MP0006054_spinal_hemorrhage1.38465403
59MP0005332_abnormal_amino_acid1.37298778
60MP0003795_abnormal_bone_structure1.36482813
61MP0002109_abnormal_limb_morphology1.36085860
62MP0003646_muscle_fatigue1.33954118
63MP0002295_abnormal_pulmonary_circulatio1.29319027
64MP0005076_abnormal_cell_differentiation1.27612312
65MP0002938_white_spotting1.27589315
66MP0002998_abnormal_bone_remodeling1.26898168
67MP0002078_abnormal_glucose_homeostasis1.25009685
68MP0000733_abnormal_muscle_development1.24966197
69MP0006072_abnormal_retinal_apoptosis1.22409576
70MP0005408_hypopigmentation1.22078086
71MP0003385_abnormal_body_wall1.21425599
72MP0003755_abnormal_palate_morphology1.20571494
73MP0000538_abnormal_urinary_bladder1.15430242
74MP0000432_abnormal_head_morphology1.15356967
75MP0003122_maternal_imprinting1.14361987
76MP0004858_abnormal_nervous_system1.10734259
77MP0004185_abnormal_adipocyte_glucose1.09545063
78MP0002116_abnormal_craniofacial_bone1.07433139
79MP0004043_abnormal_pH_regulation1.06403199
80MP0005058_abnormal_lysosome_morphology1.04513865
81MP0002111_abnormal_tail_morphology1.04121877
82MP0000639_abnormal_adrenal_gland1.03570585
83MP0000767_abnormal_smooth_muscle1.03115106
84MP0008004_abnormal_stomach_pH1.00502160
85MP0003942_abnormal_urinary_system0.99321918
86MP0001905_abnormal_dopamine_level0.98312108
87MP0000428_abnormal_craniofacial_morphol0.97412206
88MP0002932_abnormal_joint_morphology0.95905109
89MP0001348_abnormal_lacrimal_gland0.95207121
90MP0002233_abnormal_nose_morphology0.95079345
91MP0000613_abnormal_salivary_gland0.93908437
92MP0002168_other_aberrant_phenotype0.93678973
93MP0009053_abnormal_anal_canal0.93169902
94MP0001765_abnormal_ion_homeostasis0.92222090
95MP0003937_abnormal_limbs/digits/tail_de0.91578669
96MP0004197_abnormal_fetal_growth/weight/0.91383444
97MP0001501_abnormal_sleep_pattern0.90945288
98MP0002234_abnormal_pharynx_morphology0.90910980
99MP0005448_abnormal_energy_balance0.90019142
100MP0003935_abnormal_craniofacial_develop0.89073056
101MP0003300_gastrointestinal_ulcer0.87628546
102MP0003252_abnormal_bile_duct0.86913372
103MP0003953_abnormal_hormone_level0.86662032
104MP0000049_abnormal_middle_ear0.85325562
105MP0003045_fibrosis0.84861771
106MP0005646_abnormal_pituitary_gland0.84855855
107MP0001661_extended_life_span0.83179565
108MP0005636_abnormal_mineral_homeostasis0.82831579
109MP0002118_abnormal_lipid_homeostasis0.82156822
110MP0009046_muscle_twitch0.79965655
111MP0001270_distended_abdomen0.77997621
112MP0005164_abnormal_response_to0.77353457
113MP0000013_abnormal_adipose_tissue0.77266942
114MP0005075_abnormal_melanosome_morpholog0.76799206
115MP0000534_abnormal_ureter_morphology0.76720219
116MP0000516_abnormal_urinary_system0.76482555
117MP0005367_renal/urinary_system_phenotyp0.76482555
118MP0005193_abnormal_anterior_eye0.74267438
119MP0001915_intracranial_hemorrhage0.74219686
120MP0003950_abnormal_plasma_membrane0.74113197
121MP0002114_abnormal_axial_skeleton0.71842141
122MP0002128_abnormal_blood_circulation0.70755638
123MP0003329_amyloid_beta_deposits0.69445929
124MP0000537_abnormal_urethra_morphology0.69250806
125MP0005595_abnormal_vascular_smooth0.68527046
126MP0005197_abnormal_uvea_morphology0.67481015
127MP0004133_heterotaxia0.67070773
128MP0003941_abnormal_skin_development0.66825152
129MP0004085_abnormal_heartbeat0.66501966
130MP0000015_abnormal_ear_pigmentation0.66367493
131MP0001664_abnormal_digestion0.66337385
132MP0005171_absent_coat_pigmentation0.65992901
133MP0004270_analgesia0.65309356
134MP0003115_abnormal_respiratory_system0.64574177
135MP0001614_abnormal_blood_vessel0.62933408
136MP0010234_abnormal_vibrissa_follicle0.62313328
137MP0004510_myositis0.61347973
138MP0001849_ear_inflammation0.61134773
139MP0005666_abnormal_adipose_tissue0.60635408
140MP0002697_abnormal_eye_size0.60318470
141MP0005085_abnormal_gallbladder_physiolo0.59934908
142MP0003123_paternal_imprinting0.59000169
143MP0009840_abnormal_foam_cell0.58901371
144MP0003634_abnormal_glial_cell0.58433080
145MP0000427_abnormal_hair_cycle0.57136109
146MP0002249_abnormal_larynx_morphology0.55900753
147MP0000462_abnormal_digestive_system0.55747596
148MP0000230_abnormal_systemic_arterial0.55463769
149MP0009643_abnormal_urine_homeostasis0.55137596
150MP0000467_abnormal_esophagus_morphology0.54919441
151MP0003448_altered_tumor_morphology0.53690350
152MP0002925_abnormal_cardiovascular_devel0.53098875
153MP0005220_abnormal_exocrine_pancreas0.52479430
154MP0000750_abnormal_muscle_regeneration0.51919736
155MP0002092_abnormal_eye_morphology0.51727798
156MP0004084_abnormal_cardiac_muscle0.51522982
157MP0003453_abnormal_keratinocyte_physiol0.51431015
158MP0005375_adipose_tissue_phenotype0.49735081
159MP0000343_altered_response_to0.49729310
160MP0003436_decreased_susceptibility_to0.48543912
161MP0004087_abnormal_muscle_fiber0.46677361
162MP0001175_abnormal_lung_morphology0.46577822

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.68741001
2Metaphyseal cupping (HP:0003021)5.76725522
3Irregular epiphyses (HP:0010582)5.32982005
4Small epiphyses (HP:0010585)4.97713032
5Cupped ribs (HP:0000887)4.88686033
6Protrusio acetabuli (HP:0003179)4.56884021
7Premature rupture of membranes (HP:0001788)4.55873887
8Hypoplastic ischia (HP:0003175)4.49097338
9Abnormality of aromatic amino acid family metabolism (HP:0004338)4.46321002
10Vitreoretinal degeneration (HP:0000655)4.41075361
11Cardiovascular calcification (HP:0011915)4.29278911
12Mild short stature (HP:0003502)4.25660522
13Neonatal short-limb short stature (HP:0008921)4.20573469
14Flat acetabular roof (HP:0003180)4.19173490
15Cervical subluxation (HP:0003308)4.16051087
16Abnormal tarsal ossification (HP:0008369)4.15258104
17Increased CSF protein (HP:0002922)4.11162812
18Vascular calcification (HP:0004934)4.10352828
19Delayed epiphyseal ossification (HP:0002663)4.08159892
20Metaphyseal dysplasia (HP:0100255)4.02054832
21Abnormality of the ischium (HP:0003174)3.97439149
22Genu varum (HP:0002970)3.96054278
23Urinary glycosaminoglycan excretion (HP:0003541)3.87290662
24Mucopolysacchariduria (HP:0008155)3.87290662
25Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.85788972
26Flat capital femoral epiphysis (HP:0003370)3.78232795
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.77291381
28Abnormality of polysaccharide metabolism (HP:0011012)3.77291381
29Abnormality of glycosaminoglycan metabolism (HP:0004371)3.77291381
30Coxa vara (HP:0002812)3.68804795
31Abnormal foot bone ossification (HP:0010675)3.62598206
32Osteoarthritis (HP:0002758)3.56647649
33Abnormality of the vertebral endplates (HP:0005106)3.53605227
34Mitral stenosis (HP:0001718)3.51012028
35Spinal cord compression (HP:0002176)3.50309273
36Irregular vertebral endplates (HP:0003301)3.49886766
37Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.28780040
38Abnormality of femoral epiphyses (HP:0006499)3.28780040
39Platyspondyly (HP:0000926)3.22088749
40Ankle contracture (HP:0006466)3.11302949
41Hyperglycemia (HP:0003074)3.10246466
42Beaking of vertebral bodies (HP:0004568)3.06478239
43Flattened epiphyses (HP:0003071)3.06158914
44Abnormal vertebral ossification (HP:0100569)3.05302553
45Abnormality of the epiphysis of the femoral head (HP:0010574)3.01696045
46Abnormality of carpal bone ossification (HP:0006257)3.00876545
47Mesomelia (HP:0003027)3.00276551
48Radial bowing (HP:0002986)2.89607223
49Enlarged epiphyses (HP:0010580)2.87014438
50Congenital malformation of the right heart (HP:0011723)2.84898937
51Double outlet right ventricle (HP:0001719)2.84898937
52Mesangial abnormality (HP:0001966)2.84054628
53Abnormality of the acetabulum (HP:0003170)2.81675323
54Genu recurvatum (HP:0002816)2.81576729
55Limited elbow extension (HP:0001377)2.78915099
56Postural tremor (HP:0002174)2.76729428
57Stridor (HP:0010307)2.76234512
58Abnormal ossification of hand bones (HP:0005921)2.72512749
59Abnormality of the femoral head (HP:0003368)2.71551884
60Progressive neurologic deterioration (HP:0002344)2.70795179
61Vertebral clefting (HP:0008428)2.70370846
62Atrophic scars (HP:0001075)2.69009629
63Hypoplasia of the odontoid process (HP:0003311)2.68352711
64J-shaped sella turcica (HP:0002680)2.66811304
65Ulnar bowing (HP:0003031)2.66414565
66Hypoventilation (HP:0002791)2.66373918
67Short femoral neck (HP:0100864)2.65220919
68Tibial bowing (HP:0002982)2.65168099
69Abnormality of the proximal phalanges of the hand (HP:0009834)2.61619480
70Peritonitis (HP:0002586)2.61522348
71Enlarged penis (HP:0000040)2.60500195
72Dysostosis multiplex (HP:0000943)2.57409964
73Follicular hyperkeratosis (HP:0007502)2.56113296
74Wormian bones (HP:0002645)2.55905968
75Abnormality of the odontoid process (HP:0003310)2.53626597
76Ovoid vertebral bodies (HP:0003300)2.52510564
77Intestinal atresia (HP:0011100)2.52018616
78Stillbirth (HP:0003826)2.51582885
79Orthostatic hypotension (HP:0001278)2.51056263
80Abnormality of vitamin metabolism (HP:0100508)2.50761336
81Soft skin (HP:0000977)2.49978150
82Exostoses (HP:0100777)2.48871828
83Limited hip movement (HP:0008800)2.48364844
84Biconcave vertebral bodies (HP:0004586)2.45656671
85Waddling gait (HP:0002515)2.44321393
86Abnormality of vitamin B metabolism (HP:0004340)2.42432055
87Aortic dissection (HP:0002647)2.41309384
88Thoracolumbar scoliosis (HP:0002944)2.41062927
89Absent epiphyses (HP:0010577)2.40552511
90Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.40552511
91Zonular cataract (HP:0010920)2.40546574
92Absent frontal sinuses (HP:0002688)2.40515935
93Broad long bones (HP:0005622)2.40131743
94Lumbar hyperlordosis (HP:0002938)2.38965021
95Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.38759345
96Abnormal hand bone ossification (HP:0010660)2.38458937
97Xanthomatosis (HP:0000991)2.38342312
98Hip contracture (HP:0003273)2.37902769
99Popliteal pterygium (HP:0009756)2.36753484
100Hypoalbuminemia (HP:0003073)2.32752913
101Abnormal albumin level (HP:0012116)2.32752913
102Metaphyseal irregularity (HP:0003025)2.31695517
103Carpal bone hypoplasia (HP:0001498)2.30966081
104Broad phalanx (HP:0006009)2.30593631
105Flared metaphyses (HP:0003015)2.29502580
106Slender build (HP:0001533)2.28937450
107Large for gestational age (HP:0001520)2.28324084
108Shallow orbits (HP:0000586)2.26225107
109Focal dystonia (HP:0004373)2.26099867
110Abnormality of dentin (HP:0010299)2.24798707
111Torticollis (HP:0000473)2.24797326
112Mitral valve prolapse (HP:0001634)2.24370765
113Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.24071462
114Urethral obstruction (HP:0000796)2.23978440
115Femoral bowing (HP:0002980)2.19002401
116Protuberant abdomen (HP:0001538)2.18507125
117Arthropathy (HP:0003040)2.17664938
118Bowed forearm bones (HP:0003956)2.17365521
119Bowing of the arm (HP:0006488)2.17365521
120Abnormality of the distal phalanges of the toes (HP:0010182)2.16803029
121Aplasia/hypoplasia of the femur (HP:0005613)2.15648163
122Blue sclerae (HP:0000592)2.15079882
123Joint stiffness (HP:0001387)2.13614254
124Fetal akinesia sequence (HP:0001989)2.13248301
125Skin nodule (HP:0200036)2.13060858
126Type 1 muscle fiber predominance (HP:0003803)2.12037093
127Vertebral compression fractures (HP:0002953)2.11953702
128Abnormality of the 2nd finger (HP:0004100)2.09523414
129Hand muscle atrophy (HP:0009130)2.08326895
130Aortic aneurysm (HP:0004942)2.08258907
131Proximal tubulopathy (HP:0000114)2.07986109
132Spinal rigidity (HP:0003306)2.07131344
133Buphthalmos (HP:0000557)2.06777782
134Ectopia lentis (HP:0001083)2.06306058
135Dilatation of the ascending aorta (HP:0005111)2.05820710
136Abnormality of calcium-phosphate metabolism (HP:0100530)2.05731672
137Distal upper limb amyotrophy (HP:0007149)2.05650339
138Upper limb amyotrophy (HP:0009129)2.05650339
139Long toe (HP:0010511)2.03854469
140Abnormality of the calcaneus (HP:0008364)2.03700440
141Nuclear cataract (HP:0100018)2.03512578
142Fragile skin (HP:0001030)2.01725279
143Congenital glaucoma (HP:0001087)2.01027752
144Barrel-shaped chest (HP:0001552)1.99387053
145Disproportionate short-trunk short stature (HP:0003521)1.98840239
146Craniofacial dystonia (HP:0012179)1.98328259
147Short nail (HP:0001799)1.97342090
148Abnormality of the pubic bones (HP:0003172)1.97190221
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96456134
150Hemiparesis (HP:0001269)1.95090776
151Mildly elevated creatine phosphokinase (HP:0008180)1.93994260
152Abnormality of urine glucose concentration (HP:0011016)1.88361491
153Glycosuria (HP:0003076)1.88361491
154Abnormality of glycolipid metabolism (HP:0010969)1.86025749
155Abnormality of liposaccharide metabolism (HP:0010968)1.86025749
156Abnormality of glycosphingolipid metabolism (HP:0004343)1.86025749
157Upper limb muscle weakness (HP:0003484)1.85317138
158Late onset (HP:0003584)1.85001994
159Hyperphosphatemia (HP:0002905)1.84726553
160Vacuolated lymphocytes (HP:0001922)1.84280320
161Glucose intolerance (HP:0000833)1.83500535
162Congenital sensorineural hearing impairment (HP:0008527)1.82625227
163Cardiomegaly (HP:0001640)1.81989066
164Increased variability in muscle fiber diameter (HP:0003557)1.81276583
165Bladder diverticulum (HP:0000015)1.80679221
166Vascular tortuosity (HP:0004948)1.79864236
167Abnormality of the vitreous humor (HP:0004327)1.79191484
168Striae distensae (HP:0001065)1.77864061
169Broad metatarsal (HP:0001783)1.77519963
170Insulin-resistant diabetes mellitus (HP:0000831)1.73096609
171Ketoacidosis (HP:0001993)1.72781801
172Bowel diverticulosis (HP:0005222)1.72061750
173White forelock (HP:0002211)1.70993052
174Patchy hypopigmentation of hair (HP:0011365)1.70384941
175Tongue fasciculations (HP:0001308)1.69341608
176Testicular neoplasm (HP:0010788)1.69163392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.26328444
2LMTK25.15065854
3TTN4.39459727
4EPHA24.13895982
5PHKG23.63250593
6PHKG13.63250593
7TRIB33.30909197
8MYLK2.98626099
9LATS12.97928492
10GRK12.84768030
11STK38L2.84475625
12MAP3K32.74286153
13MAP4K22.38263732
14PDGFRA2.29715141
15SIK12.25189340
16PKN22.18206204
17DAPK22.17641596
18TRPM71.96420932
19AKT31.88150349
20MST41.83101819
21STK31.78268865
22EEF2K1.75744132
23PRKG21.74962812
24FGFR21.70949236
25MAP3K121.69491235
26PAK21.69204053
27BMX1.63974085
28LATS21.63508410
29PTK21.62339039
30PIM21.59582039
31STK381.58250833
32STK241.51183805
33RIPK11.49265618
34MET1.48672215
35MAP3K91.47873732
36ADRBK21.39108679
37PAK31.37610559
38FER1.37072957
39PTK61.33838958
40PRKCE1.31049265
41PRKD21.29116586
42PAK41.26197173
43LRRK21.25661821
44RPS6KA41.10821309
45MAP2K61.10673928
46WNK31.09267586
47PINK11.06111397
48PIK3CA1.05525324
49ERN11.04925306
50PDGFRB1.02198683
51CSNK1G11.01567325
52NME21.01503114
53NTRK31.00467437
54TESK10.97836514
55EPHB20.97777355
56MTOR0.97272566
57FGFR10.95777906
58CSNK1G30.88761932
59FRK0.87557012
60TGFBR10.85318233
61ROCK10.84727260
62STK100.83421646
63PLK20.82923549
64CAMK2D0.82915888
65MAP2K10.80428105
66PRKD30.80047998
67ERBB30.79409346
68PRKCG0.78971914
69RPS6KB20.78752118
70EPHA40.78388138
71MOS0.76043296
72FGFR40.75583079
73CAMKK20.75093343
74CDC42BPA0.75073576
75NEK90.73654239
76LIMK10.72897387
77SCYL20.69960812
78MST1R0.69895300
79CSNK1G20.68340129
80HIPK20.68337500
81MAP2K30.67836085
82FLT30.66762789
83PTK2B0.65903686
84WNK40.64678553
85CDK120.63392176
86EPHB10.62476178
87ERBB40.62278595
88PRKCI0.62065949
89TGFBR20.61981573
90DAPK10.60059517
91MUSK0.58530359
92TAOK10.58314324
93NTRK10.56060156
94CDK60.55101937
95NUAK10.54086804
96INSR0.52624877
97YES10.52444911
98CAMKK10.51882307
99EPHA30.51767543
100PRKAA20.51111418
101ILK0.50285280
102PDK20.49733834
103MAP3K80.48588598
104PAK60.48173141
105RET0.47397357
106INSRR0.46774897
107JAK10.46610700
108STK40.45806276
109NME10.45574198
110PBK0.45308950
111MAP3K40.44155336
112ABL20.43810002
113MELK0.43486807
114CAMK1D0.43083948
115ROCK20.42813366
116PRKAA10.42403061
117MKNK20.42393354
118MAP3K100.42148018
119FGFR30.41503103
120GSK3A0.40061553
121DYRK1B0.39732407
122CASK0.38474242
123PIM10.38311771
124BRSK20.38087246
125CSNK1A1L0.36509827
126PRKG10.35635959
127CSNK1A10.34688145
128NLK0.34197526
129PAK10.34159383
130CAMK2G0.32884506
131DMPK0.31044008
132SRC0.30161701
133DAPK30.28515800
134MAP3K140.26297962
135ABL10.25921112
136TBK10.25805051
137MAPK10.25583101
138AURKB0.24884628
139JAK30.24745947
140IGF1R0.23341644
141EGFR0.23296577
142CSF1R0.21748625
143MAP3K20.20976034
144ADRBK10.20414302
145PRKD10.20071259
146KSR10.18495041
147CHUK0.17942622

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.96198484
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.57431509
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.49275439
4Protein digestion and absorption_Homo sapiens_hsa049743.82249506
5Focal adhesion_Homo sapiens_hsa045103.42679159
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.72310339
7Other glycan degradation_Homo sapiens_hsa005112.66495190
8Vitamin B6 metabolism_Homo sapiens_hsa007502.36419016
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.28141519
10Bladder cancer_Homo sapiens_hsa052192.26463793
11Proteoglycans in cancer_Homo sapiens_hsa052052.25133266
12Insulin secretion_Homo sapiens_hsa049112.08553339
13Malaria_Homo sapiens_hsa051441.98411192
14Small cell lung cancer_Homo sapiens_hsa052221.90550023
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.89995842
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.82187671
17TGF-beta signaling pathway_Homo sapiens_hsa043501.79136370
18Amoebiasis_Homo sapiens_hsa051461.71524188
19Hippo signaling pathway_Homo sapiens_hsa043901.71446726
20Adherens junction_Homo sapiens_hsa045201.69840651
21Protein export_Homo sapiens_hsa030601.67350013
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.66147074
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.61136278
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.59700468
25Circadian rhythm_Homo sapiens_hsa047101.55554416
26MicroRNAs in cancer_Homo sapiens_hsa052061.52808217
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50079273
28Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.48537886
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48494295
30Vibrio cholerae infection_Homo sapiens_hsa051101.42001070
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.39687452
32Lysosome_Homo sapiens_hsa041421.36550532
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.36378241
34Collecting duct acid secretion_Homo sapiens_hsa049661.27636301
35Chronic myeloid leukemia_Homo sapiens_hsa052201.26968509
36Glucagon signaling pathway_Homo sapiens_hsa049221.26836084
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.22849489
38Basal cell carcinoma_Homo sapiens_hsa052171.21132351
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20586187
40One carbon pool by folate_Homo sapiens_hsa006701.18711907
41Steroid biosynthesis_Homo sapiens_hsa001001.13608136
42Glutathione metabolism_Homo sapiens_hsa004801.13380443
43Selenocompound metabolism_Homo sapiens_hsa004501.10371235
44Hedgehog signaling pathway_Homo sapiens_hsa043401.10270922
45Nitrogen metabolism_Homo sapiens_hsa009101.10039696
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08898930
47Butanoate metabolism_Homo sapiens_hsa006501.07916166
48p53 signaling pathway_Homo sapiens_hsa041151.07115743
49Dilated cardiomyopathy_Homo sapiens_hsa054141.04290620
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04211661
51Melanoma_Homo sapiens_hsa052181.03894556
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03435867
53Prostate cancer_Homo sapiens_hsa052151.00120290
54Complement and coagulation cascades_Homo sapiens_hsa046100.99255072
55Glioma_Homo sapiens_hsa052140.97811277
56Sulfur metabolism_Homo sapiens_hsa009200.95747263
57Central carbon metabolism in cancer_Homo sapiens_hsa052300.95225483
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94332850
59Ether lipid metabolism_Homo sapiens_hsa005650.90469349
60Phagosome_Homo sapiens_hsa041450.89635165
61Starch and sucrose metabolism_Homo sapiens_hsa005000.88690690
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87142203
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86749864
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86498551
65Retinol metabolism_Homo sapiens_hsa008300.85191788
66Pancreatic cancer_Homo sapiens_hsa052120.84031421
67ABC transporters_Homo sapiens_hsa020100.83932950
68Mineral absorption_Homo sapiens_hsa049780.83607156
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83425453
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.80877912
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80578350
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79400341
73Peroxisome_Homo sapiens_hsa041460.78752364
74Histidine metabolism_Homo sapiens_hsa003400.77884609
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77673781
76Arginine biosynthesis_Homo sapiens_hsa002200.77088233
77Renin secretion_Homo sapiens_hsa049240.76850402
78Platelet activation_Homo sapiens_hsa046110.76807793
79TNF signaling pathway_Homo sapiens_hsa046680.75728297
80Ovarian steroidogenesis_Homo sapiens_hsa049130.75685654
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75590185
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75070913
83Lysine degradation_Homo sapiens_hsa003100.72899137
84HTLV-I infection_Homo sapiens_hsa051660.72154428
85HIF-1 signaling pathway_Homo sapiens_hsa040660.71656208
86Shigellosis_Homo sapiens_hsa051310.70535960
87Synaptic vesicle cycle_Homo sapiens_hsa047210.69715480
88Oxidative phosphorylation_Homo sapiens_hsa001900.69468199
89Inositol phosphate metabolism_Homo sapiens_hsa005620.69385673
90Hepatitis B_Homo sapiens_hsa051610.69165057
91Viral carcinogenesis_Homo sapiens_hsa052030.68450027
92Toxoplasmosis_Homo sapiens_hsa051450.67835608
93Tight junction_Homo sapiens_hsa045300.67561102
94Pancreatic secretion_Homo sapiens_hsa049720.66816398
95Apoptosis_Homo sapiens_hsa042100.66449461
96Pathways in cancer_Homo sapiens_hsa052000.65757570
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65424719
98Phenylalanine metabolism_Homo sapiens_hsa003600.64692803
99N-Glycan biosynthesis_Homo sapiens_hsa005100.63833176
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63400739
101Tyrosine metabolism_Homo sapiens_hsa003500.63035813
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62403708
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60557378
104Renal cell carcinoma_Homo sapiens_hsa052110.60214238
105Biosynthesis of amino acids_Homo sapiens_hsa012300.59695358
106mTOR signaling pathway_Homo sapiens_hsa041500.59548802
107Metabolic pathways_Homo sapiens_hsa011000.59247809
108Rap1 signaling pathway_Homo sapiens_hsa040150.58715064
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58387385
110Arginine and proline metabolism_Homo sapiens_hsa003300.58241117
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.57995660
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54929134
113beta-Alanine metabolism_Homo sapiens_hsa004100.54648970
114Gap junction_Homo sapiens_hsa045400.53859784
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53400936
116Sphingolipid metabolism_Homo sapiens_hsa006000.52971658
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.51368293
118Bile secretion_Homo sapiens_hsa049760.51135010
119Arachidonic acid metabolism_Homo sapiens_hsa005900.51057906
120Viral myocarditis_Homo sapiens_hsa054160.50365993
121Dopaminergic synapse_Homo sapiens_hsa047280.50023851
122Amphetamine addiction_Homo sapiens_hsa050310.48939482
123Salivary secretion_Homo sapiens_hsa049700.48441952
124Folate biosynthesis_Homo sapiens_hsa007900.47784677
125Circadian entrainment_Homo sapiens_hsa047130.46621038
126Chemical carcinogenesis_Homo sapiens_hsa052040.44509101
127Serotonergic synapse_Homo sapiens_hsa047260.43658929
128Vitamin digestion and absorption_Homo sapiens_hsa049770.43281794
129Wnt signaling pathway_Homo sapiens_hsa043100.43167961
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43024120
131Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42154568
132GABAergic synapse_Homo sapiens_hsa047270.41379620
133FoxO signaling pathway_Homo sapiens_hsa040680.41000909
134Colorectal cancer_Homo sapiens_hsa052100.40672719
135Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39369763
136Fatty acid elongation_Homo sapiens_hsa000620.39297347
137Cocaine addiction_Homo sapiens_hsa050300.39183860
138Propanoate metabolism_Homo sapiens_hsa006400.38777806
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38376220
140Endometrial cancer_Homo sapiens_hsa052130.37854016
141PPAR signaling pathway_Homo sapiens_hsa033200.37699202
142Insulin resistance_Homo sapiens_hsa049310.37519088
143Steroid hormone biosynthesis_Homo sapiens_hsa001400.37164007
144Axon guidance_Homo sapiens_hsa043600.37132983
145VEGF signaling pathway_Homo sapiens_hsa043700.36572736
146Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35276772
147Thyroid hormone synthesis_Homo sapiens_hsa049180.32804678
148Tryptophan metabolism_Homo sapiens_hsa003800.32681366
149Fat digestion and absorption_Homo sapiens_hsa049750.32179947
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32115140
151Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31975278
1522-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31590146
153Salmonella infection_Homo sapiens_hsa051320.31399698
154Dorso-ventral axis formation_Homo sapiens_hsa043200.31286978
155Thyroid cancer_Homo sapiens_hsa052160.31233647
156Adipocytokine signaling pathway_Homo sapiens_hsa049200.30858744
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.30323321
158Calcium signaling pathway_Homo sapiens_hsa040200.29869376
159cAMP signaling pathway_Homo sapiens_hsa040240.29424401
160Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28700777
161Osteoclast differentiation_Homo sapiens_hsa043800.28426532
162AMPK signaling pathway_Homo sapiens_hsa041520.28338361

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