LOR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)9.64676129
2water homeostasis (GO:0030104)8.75181804
3* keratinocyte differentiation (GO:0030216)8.41963858
4* peptide cross-linking (GO:0018149)8.20676356
5intermediate filament organization (GO:0045109)6.67925244
6long-chain fatty acid biosynthetic process (GO:0042759)6.59296998
7skin morphogenesis (GO:0043589)6.55021547
8* epidermal cell differentiation (GO:0009913)6.52553402
9epidermis development (GO:0008544)6.33779350
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.29655886
11linoleic acid metabolic process (GO:0043651)4.92678089
12ectoderm development (GO:0007398)4.80535900
13fatty acid elongation (GO:0030497)4.69230270
14keratinocyte proliferation (GO:0043616)4.66918243
15gap junction assembly (GO:0016264)4.40084149
16intermediate filament cytoskeleton organization (GO:0045104)4.33853572
17lateral sprouting from an epithelium (GO:0060601)4.28171077
18intermediate filament-based process (GO:0045103)4.25392531
19negative regulation of interferon-gamma production (GO:0032689)4.24270228
20lipoxygenase pathway (GO:0019372)4.21350110
21epithelial cell differentiation involved in prostate gland development (GO:0060742)4.13261551
22skin development (GO:0043588)4.04728334
23phosphatidylcholine acyl-chain remodeling (GO:0036151)4.04060934
24regulation of ruffle assembly (GO:1900027)3.96748242
25polarized epithelial cell differentiation (GO:0030859)3.90715461
26detection of bacterium (GO:0016045)3.90189654
27keratinocyte development (GO:0003334)3.83438428
28ceramide biosynthetic process (GO:0046513)3.65339600
29glucosamine-containing compound catabolic process (GO:1901072)3.64461422
30actin-myosin filament sliding (GO:0033275)3.62047537
31muscle filament sliding (GO:0030049)3.62047537
32phosphatidylserine metabolic process (GO:0006658)3.50980567
33regulation of skeletal muscle contraction (GO:0014819)3.50033274
34negative regulation of cell fate specification (GO:0009996)3.39957033
35cell wall macromolecule catabolic process (GO:0016998)3.39327757
36cell wall macromolecule metabolic process (GO:0044036)3.39327757
37surfactant homeostasis (GO:0043129)3.36125056
38cell-substrate junction assembly (GO:0007044)3.35018071
39planar cell polarity pathway involved in neural tube closure (GO:0090179)3.29171610
40detection of other organism (GO:0098543)3.26690186
41atrioventricular valve morphogenesis (GO:0003181)3.23778139
42negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.20902870
43adhesion of symbiont to host cell (GO:0044650)3.20879374
44virion attachment to host cell (GO:0019062)3.20879374
45positive regulation of monocyte chemotaxis (GO:0090026)3.16363146
46detection of external biotic stimulus (GO:0098581)3.15915796
47regulation of transforming growth factor beta1 production (GO:0032908)3.14302739
48phosphatidylinositol acyl-chain remodeling (GO:0036149)3.13462802
49phospholipid catabolic process (GO:0009395)3.10493827
50actin-mediated cell contraction (GO:0070252)3.10133879
51regulation of cell proliferation involved in kidney development (GO:1901722)3.08147859
52positive regulation of epidermal cell differentiation (GO:0045606)3.05698906
53chemical homeostasis within a tissue (GO:0048875)3.04607962
54positive regulation of glomerulus development (GO:0090193)3.02235679
55regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.01201221
56* keratinization (GO:0031424)20.8367977
57epithelium development (GO:0060429)2.96054210
58positive regulation of interleukin-8 secretion (GO:2000484)2.94708565
59establishment of planar polarity (GO:0001736)2.93997992
60establishment of tissue polarity (GO:0007164)2.93997992
61one-carbon compound transport (GO:0019755)2.93820386
62long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.93638791
63phospholipid efflux (GO:0033700)2.89606012
64sphingosine metabolic process (GO:0006670)2.87223406
65regulation of keratinocyte differentiation (GO:0045616)2.86393340
66regulation of keratinocyte proliferation (GO:0010837)2.86112520
67eyelid development in camera-type eye (GO:0061029)2.84234981
68positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.81762663
69alditol phosphate metabolic process (GO:0052646)2.81037408
70fibrinolysis (GO:0042730)2.80025667
71negative regulation of interleukin-17 production (GO:0032700)2.79404299
72skeletal muscle adaptation (GO:0043501)2.79401949
73positive regulation of epidermis development (GO:0045684)2.77718444
74regulation of cardioblast differentiation (GO:0051890)2.77267267
75ventricular cardiac muscle cell action potential (GO:0086005)2.76020938
76positive regulation of cholesterol efflux (GO:0010875)2.74932565
77retinol metabolic process (GO:0042572)2.74825123
78hormone catabolic process (GO:0042447)2.71722514
79negative regulation of cell fate commitment (GO:0010454)2.71049102
80phosphatidylserine acyl-chain remodeling (GO:0036150)2.70620618
81regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.70216023
82regulation of T cell chemotaxis (GO:0010819)2.68823578
83positive regulation of T cell chemotaxis (GO:0010820)2.68823578
84skeletal muscle contraction (GO:0003009)2.68148800
85detection of biotic stimulus (GO:0009595)2.68117097
86plasma membrane repair (GO:0001778)2.68032319
87defense response to fungus (GO:0050832)2.67353276
88epithelial cell-cell adhesion (GO:0090136)2.67170607
89regulation of skeletal muscle cell differentiation (GO:2001014)2.66893325
90positive regulation of keratinocyte differentiation (GO:0045618)2.66679801
91sphingoid metabolic process (GO:0046519)2.66082019
92sarcoplasmic reticulum calcium ion transport (GO:0070296)2.64385028
93sphingolipid biosynthetic process (GO:0030148)2.62350334
94polyol transport (GO:0015791)2.59658469
95skeletal muscle fiber development (GO:0048741)2.58128012
96regulation of epidermal cell differentiation (GO:0045604)2.57882380
97negative regulation of keratinocyte proliferation (GO:0010839)2.56882015
98adhesion of symbiont to host (GO:0044406)2.55860121
99long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.53988063
100unsaturated fatty acid biosynthetic process (GO:0006636)2.53847818
101diol metabolic process (GO:0034311)2.52178004
102phosphatidylglycerol metabolic process (GO:0046471)2.51958968
103actin filament-based movement (GO:0030048)2.51644360
104non-canonical Wnt signaling pathway (GO:0035567)2.49309775
105fatty-acyl-CoA metabolic process (GO:0035337)2.48991670
106sequestering of metal ion (GO:0051238)2.48710852
107myotube differentiation (GO:0014902)2.47564464
108hair follicle morphogenesis (GO:0031069)2.45720930
109regulation of natural killer cell differentiation (GO:0032823)2.45059992
110hair follicle development (GO:0001942)2.44952378
111phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.44183502
112positive regulation of cholesterol transport (GO:0032376)2.43644209
113positive regulation of sterol transport (GO:0032373)2.43644209
114hair cycle process (GO:0022405)2.43012685
115molting cycle process (GO:0022404)2.43012685
116epithelial cell proliferation (GO:0050673)2.41566685
117fatty-acyl-CoA biosynthetic process (GO:0046949)2.40907852
118ephrin receptor signaling pathway (GO:0048013)2.39909433
119G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.39154058
120very long-chain fatty acid metabolic process (GO:0000038)2.39078352
121negative regulation of stress fiber assembly (GO:0051497)2.39077758
122cellular response to calcium ion (GO:0071277)2.38877014
123regulation of neuron projection regeneration (GO:0070570)2.37489707
124regulation of axon regeneration (GO:0048679)2.37489707
125regulation of protein localization to cell surface (GO:2000008)2.36578535
126cytoskeletal anchoring at plasma membrane (GO:0007016)2.35977051
127intestinal epithelial cell development (GO:0060576)2.35455551
128regulation of epidermis development (GO:0045682)2.35226293
129regulation of natural killer cell activation (GO:0032814)2.34986168
130phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.33908179
131regulation of monocyte chemotaxis (GO:0090025)2.33336041
132response to phenylpropanoid (GO:0080184)2.33162617
133cellular response to antibiotic (GO:0071236)2.28200956
134regulation of heart rate by cardiac conduction (GO:0086091)2.27117703
135positive regulation of chemokine secretion (GO:0090197)2.25219175
136regulation of chemokine secretion (GO:0090196)2.20614442
137cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.17712394
138* epithelial cell differentiation (GO:0030855)2.17190981
139establishment of skin barrier (GO:0061436)18.6568546
140regulation of water loss via skin (GO:0033561)16.1308766
141desmosome organization (GO:0002934)13.4309800
142hair cycle (GO:0042633)11.7063045
143molting cycle (GO:0042303)11.7063045
144multicellular organismal water homeostasis (GO:0050891)10.5835756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.88411315
2P63_26484246_Chip-Seq_KERATINOCYTES_Human3.37210788
3ZNF263_19887448_ChIP-Seq_K562_Human2.72342540
4ESR1_21235772_ChIP-Seq_MCF-7_Human2.55185423
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.52627664
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.40079323
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.04577561
8TP63_17297297_ChIP-ChIP_HaCaT_Human14.6640592
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.97568109
10TRIM28_21343339_ChIP-Seq_HEK293_Human1.88728843
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.86201430
12FOXO3_23340844_ChIP-Seq_DLD1_Human1.82243037
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.80085990
14SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.80085990
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78899354
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78843974
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60479162
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60234036
19CTCF_27219007_Chip-Seq_Bcells_Human1.58270157
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55577314
21TP63_22573176_ChIP-Seq_HFKS_Human1.54496318
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50822572
23RACK7_27058665_Chip-Seq_MCF-7_Human1.47328454
24DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46530401
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45472749
26TP63_23658742_ChIP-Seq_EP156T_Human1.40354721
27* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.36817550
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34487420
29LXR_22292898_ChIP-Seq_THP-1_Human1.31581967
30* CTCF_20526341_ChIP-Seq_ESCs_Human1.28871127
31KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26561597
32AR_21572438_ChIP-Seq_LNCaP_Human1.25036726
33ATF3_27146783_Chip-Seq_COLON_Human1.24552884
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23122264
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.23040080
36* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20785521
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19829943
38* GATA6_21074721_ChIP-Seq_CACO-2_Human1.19810736
39KLF5_25053715_ChIP-Seq_YYC3_Human1.17985354
40SOX2_20726797_ChIP-Seq_SW620_Human1.16414667
41GATA3_24758297_ChIP-Seq_MCF-7_Human1.16369527
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.15823554
43SA1_27219007_Chip-Seq_ERYTHROID_Human1.14904292
44CJUN_26792858_Chip-Seq_BT549_Human1.14871128
45TP53_20018659_ChIP-ChIP_R1E_Mouse1.14632579
46E2F1_20622854_ChIP-Seq_HELA_Human1.11148255
47* BCOR_27268052_Chip-Seq_Bcells_Human1.08486205
48BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08461066
49* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.08151356
50P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.08146341
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07705074
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.07666140
53JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07193003
54TP53_18474530_ChIP-ChIP_U2OS_Human1.06433284
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05968571
56ERG_20517297_ChIP-Seq_VCAP_Human1.05964732
57* CEBPB_22108803_ChIP-Seq_LS180_Human1.03829976
58UBF1/2_26484160_Chip-Seq_HMECs_Human1.02641784
59BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01448852
60TCF4_18268006_ChIP-ChIP_LS174T_Human1.01362533
61EGR1_19032775_ChIP-ChIP_M12_Human0.99317903
62STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98854111
63AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.98717054
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.98384789
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97846472
66ERG_21242973_ChIP-ChIP_JURKAT_Human0.97464231
67* RXR_22108803_ChIP-Seq_LS180_Human0.97166642
68* P68_20966046_ChIP-Seq_HELA_Human0.97127813
69ESR1_20079471_ChIP-ChIP_T-47D_Human0.96845554
70* EZH2_27294783_Chip-Seq_ESCs_Mouse0.96466976
71BCL6_27268052_Chip-Seq_Bcells_Human0.94561135
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94391661
73ARNT_22903824_ChIP-Seq_MCF-7_Human0.91943400
74KDM2B_26808549_Chip-Seq_K562_Human0.90588668
75SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89435743
76TAF2_19829295_ChIP-Seq_ESCs_Human0.87324638
77PIAS1_25552417_ChIP-Seq_VCAP_Human0.87281453
78NANOG_20526341_ChIP-Seq_ESCs_Human0.86904905
79* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84836609
80RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83722717
81EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83722717
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83687345
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83687345
84CLOCK_20551151_ChIP-Seq_293T_Human0.83585895
85ELK3_25401928_ChIP-Seq_HUVEC_Human0.83246385
86AHR_22903824_ChIP-Seq_MCF-7_Human0.83130006
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82737627
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82449377
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82167794
90BCAT_22108803_ChIP-Seq_LS180_Human0.81534321
91CSB_26484114_Chip-Seq_FIBROBLAST_Human0.81483071
92KDM2B_26808549_Chip-Seq_DND41_Human0.80528776
93* RNF2_27304074_Chip-Seq_ESCs_Mouse0.80337465
94FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80169399
95P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78274273
96* EZH2_27304074_Chip-Seq_ESCs_Mouse0.76389973
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.76247863
98* SMC4_20622854_ChIP-Seq_HELA_Human0.75955572
99* HNFA_21074721_ChIP-Seq_CACO-2_Human0.75412180
100* SMAD4_21741376_ChIP-Seq_ESCs_Human0.74831599
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74457669
102SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.74030315
103JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74013631
104* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.73910640
105* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.73689781
106GATA6_25053715_ChIP-Seq_YYC3_Human0.73507360
107TP53_16413492_ChIP-PET_HCT116_Human0.73019189
108PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72905691
109GATA4_25053715_ChIP-Seq_YYC3_Human0.72831883
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72812503
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72521415
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72010253
113TBX20_22328084_ChIP-Seq_HEART_Mouse0.71810227
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.71810227
115P53_21459846_ChIP-Seq_SAOS-2_Human0.71784092
116KDM2B_26808549_Chip-Seq_SUP-B15_Human0.71325763
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70944247
118FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70352698
119RAC3_21632823_ChIP-Seq_H3396_Human0.70158039
120* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.70124436
121* RBPJ_21746931_ChIP-Seq_IB4_Human0.69606676
122* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.68694610
123GATA2_19941826_ChIP-Seq_K562_Human0.68196639
124FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.67899360
125FOXA1_25552417_ChIP-Seq_VCAP_Human0.67232743
126* TCF4_22108803_ChIP-Seq_LS180_Human0.64872380
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64477329
128CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.64320899
129PPARA_22158963_ChIP-Seq_LIVER_Mouse0.64037939
130WT1_25993318_ChIP-Seq_PODOCYTE_Human0.63671880
131TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63403372
132* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.62540843
133CDX2_22108803_ChIP-Seq_LS180_Human0.61477336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier8.38068301
2* MP0005275_abnormal_skin_tensile5.97269087
3MP0000579_abnormal_nail_morphology5.14751847
4* MP0005501_abnormal_skin_physiology5.11952233
5MP0010234_abnormal_vibrissa_follicle4.93058924
6MP0003941_abnormal_skin_development4.02659975
7MP0002060_abnormal_skin_morphology3.71851770
8* MP0001216_abnormal_epidermal_layer3.45537244
9MP0003705_abnormal_hypodermis_morpholog3.43258185
10MP0002254_reproductive_system_inflammat3.24799109
11* MP0010771_integument_phenotype3.18722944
12MP0000383_abnormal_hair_follicle3.08146909
13MP0000647_abnormal_sebaceous_gland3.08066853
14MP0010678_abnormal_skin_adnexa2.92784142
15MP0004381_abnormal_hair_follicle2.91363671
16MP0005451_abnormal_body_composition2.84055898
17MP0000467_abnormal_esophagus_morphology2.83226499
18* MP0004947_skin_inflammation2.76199651
19MP0002098_abnormal_vibrissa_morphology2.63518014
20MP0003453_abnormal_keratinocyte_physiol2.47560752
21MP0000377_abnormal_hair_follicle2.41267033
22MP0000427_abnormal_hair_cycle2.39285347
23MP0000762_abnormal_tongue_morphology2.29409151
24MP0000015_abnormal_ear_pigmentation2.22164126
25MP0001243_abnormal_dermal_layer2.12081437
26MP0005174_abnormal_tail_pigmentation2.04584966
27MP0004185_abnormal_adipocyte_glucose2.01815150
28MP0004885_abnormal_endolymph2.00304041
29MP0005377_hearing/vestibular/ear_phenot1.92474013
30MP0003878_abnormal_ear_physiology1.92474013
31MP0002234_abnormal_pharynx_morphology1.92102095
32* MP0009931_abnormal_skin_appearance1.86220572
33MP0003191_abnormal_cellular_cholesterol1.85857612
34MP0003011_delayed_dark_adaptation1.72506888
35* MP0001191_abnormal_skin_condition1.51676934
36MP0000367_abnormal_coat/_hair1.50579922
37MP0001188_hyperpigmentation1.48290038
38MP0003566_abnormal_cell_adhesion1.42997691
39MP0005075_abnormal_melanosome_morpholog1.15430116
40MP0000751_myopathy1.09187803
41MP0000566_synostosis1.00439422
42MP0001346_abnormal_lacrimal_gland0.97536739
43MP0001851_eye_inflammation0.96570722
44MP0002095_abnormal_skin_pigmentation0.94408193
45MP0000749_muscle_degeneration0.93156972
46MP0004264_abnormal_extraembryonic_tissu0.92720177
47MP0000465_gastrointestinal_hemorrhage0.90644248
48MP0010030_abnormal_orbit_morphology0.89294289
49MP0001340_abnormal_eyelid_morphology0.86473227
50MP0008438_abnormal_cutaneous_collagen0.85232395
51MP0004782_abnormal_surfactant_physiolog0.85221744
52MP0005409_darkened_coat_color0.82094279
53MP0008961_abnormal_basal_metabolism0.79997623
54MP0000747_muscle_weakness0.77070637
55MP0002177_abnormal_outer_ear0.75027643
56MP0001849_ear_inflammation0.74868473
57MP0009053_abnormal_anal_canal0.74136347
58MP0005666_abnormal_adipose_tissue0.72341318
59* MP0001784_abnormal_fluid_regulation0.66120270
60MP0005171_absent_coat_pigmentation0.65178996
61MP0003950_abnormal_plasma_membrane0.61364944
62MP0005023_abnormal_wound_healing0.60291682
63MP0001984_abnormal_olfaction0.59495820
64MP0000750_abnormal_muscle_regeneration0.57703046
65MP0000569_abnormal_digit_pigmentation0.56031436
66MP0003755_abnormal_palate_morphology0.55857533
67MP0003763_abnormal_thymus_physiology0.55789393
68MP0000759_abnormal_skeletal_muscle0.55240115
69MP0002009_preneoplasia0.54051268
70MP0009780_abnormal_chondrocyte_physiolo0.52106981
71MP0004087_abnormal_muscle_fiber0.51524182
72MP0005375_adipose_tissue_phenotype0.51343968
73MP0002106_abnormal_muscle_physiology0.50305182
74MP0003329_amyloid_beta_deposits0.49611999
75MP0005620_abnormal_muscle_contractility0.48820863
76MP0002111_abnormal_tail_morphology0.48010381
77MP0002249_abnormal_larynx_morphology0.47885176
78MP0000733_abnormal_muscle_development0.45852807
79MP0002877_abnormal_melanocyte_morpholog0.44813165
80MP0004145_abnormal_muscle_electrophysio0.43515151
81MP0001186_pigmentation_phenotype0.41997637
82MP0000372_irregular_coat_pigmentation0.41388305
83MP0009379_abnormal_foot_pigmentation0.41235913
84MP0005503_abnormal_tendon_morphology0.38610383
85MP0005076_abnormal_cell_differentiation0.37466259
86MP0005369_muscle_phenotype0.37335740
87MP0006054_spinal_hemorrhage0.36214312
88MP0002282_abnormal_trachea_morphology0.35895895
89MP0003300_gastrointestinal_ulcer0.35864383
90MP0000627_abnormal_mammary_gland0.35636472
91MP0004130_abnormal_muscle_cell0.35419567
92MP0003638_abnormal_response/metabolism_0.34351141
93MP0009672_abnormal_birth_weight0.33508216
94MP0000470_abnormal_stomach_morphology0.33068480
95MP0002166_altered_tumor_susceptibility0.31844626
96MP0009333_abnormal_splenocyte_physiolog0.31688016
97MP0003385_abnormal_body_wall0.31631177
98MP0005330_cardiomyopathy0.31488596
99MP0002971_abnormal_brown_adipose0.31392143
100MP0001299_abnormal_eye_distance/0.31389047
101MP0001177_atelectasis0.31348839
102MP0008789_abnormal_olfactory_epithelium0.30856203
103MP0004036_abnormal_muscle_relaxation0.30209675
104MP0005647_abnormal_sex_gland0.29838169
105MP0005499_abnormal_olfactory_system0.29119443
106MP0005394_taste/olfaction_phenotype0.29119443
107MP0005257_abnormal_intraocular_pressure0.29102464
108MP0002837_dystrophic_cardiac_calcinosis0.28999143
109MP0002133_abnormal_respiratory_system0.28936400
110MP0005388_respiratory_system_phenotype0.28936400
111MP0010352_gastrointestinal_tract_polyps0.28211022
112MP0002896_abnormal_bone_mineralization0.27691096
113MP0000537_abnormal_urethra_morphology0.27493012
114MP0002006_tumorigenesis0.27464170
115MP0002972_abnormal_cardiac_muscle0.25160376
116MP0004272_abnormal_basement_membrane0.25104888
117MP0002269_muscular_atrophy0.25081862
118MP0000538_abnormal_urinary_bladder0.24130947
119MP0004858_abnormal_nervous_system0.23711803
120MP0003315_abnormal_perineum_morphology0.22904377
121MP0000685_abnormal_immune_system0.22300908
122MP0000428_abnormal_craniofacial_morphol0.21808390
123MP0002108_abnormal_muscle_morphology0.21202664
124MP0000432_abnormal_head_morphology0.20972591
125MP0008004_abnormal_stomach_pH0.20706283
126MP0003646_muscle_fatigue0.20455307
127MP0000013_abnormal_adipose_tissue0.20258154
128MP0002332_abnormal_exercise_endurance0.20087375
129MP0000371_diluted_coat_color0.19854937
130MP0000462_abnormal_digestive_system0.19019385
131MP0000678_abnormal_parathyroid_gland0.18920010
132MP0002233_abnormal_nose_morphology0.16657534
133MP0002138_abnormal_hepatobiliary_system0.16469240
134MP0002075_abnormal_coat/hair_pigmentati0.16232631
135MP0005408_hypopigmentation0.15183363
136MP0004197_abnormal_fetal_growth/weight/0.14782788
137MP0009384_cardiac_valve_regurgitation0.13979806
138MP0001958_emphysema0.13224028
139MP0002697_abnormal_eye_size0.12455168
140MP0005508_abnormal_skeleton_morphology0.12254657
141MP0005248_abnormal_Harderian_gland0.11685144
142MP0005193_abnormal_anterior_eye0.11620312
143MP0008569_lethality_at_weaning0.11296129
144MP0001485_abnormal_pinna_reflex0.11025631

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)8.78380779
2Abnormality of nail color (HP:0100643)7.53921749
3Hypotrichosis (HP:0001006)7.44812114
4Palmoplantar hyperkeratosis (HP:0000972)6.89303364
5Plantar hyperkeratosis (HP:0007556)6.85952148
6Conjunctival hamartoma (HP:0100780)6.68985967
7Palmar hyperkeratosis (HP:0010765)6.49533770
8Abnormality of secondary sexual hair (HP:0009888)6.26481365
9Abnormality of the axillary hair (HP:0100134)6.26481365
10Congenital ichthyosiform erythroderma (HP:0007431)6.01849094
11Onycholysis (HP:0001806)5.94017186
12Thick nail (HP:0001805)5.89142667
13Woolly hair (HP:0002224)5.83186438
14Erythroderma (HP:0001019)5.76145978
15Milia (HP:0001056)5.40383126
16Erythema (HP:0010783)5.34241509
17Right ventricular cardiomyopathy (HP:0011663)5.16782282
18Fragile nails (HP:0001808)5.06966927
19Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.05364383
20Pili torti (HP:0003777)4.91495130
21Gangrene (HP:0100758)4.58740845
22Hamartoma of the eye (HP:0010568)4.31980019
23Oral leukoplakia (HP:0002745)4.29418352
24Abnormal blistering of the skin (HP:0008066)4.16818699
25Nail dystrophy (HP:0008404)4.01568159
26Hyporeflexia of lower limbs (HP:0002600)3.92894632
27Corneal erosion (HP:0200020)3.89114435
28Ectropion (HP:0000656)3.87465180
29Absent eyelashes (HP:0000561)3.81747069
30Type 1 muscle fiber predominance (HP:0003803)3.79841348
31Alopecia of scalp (HP:0002293)3.66920474
32Muscle fiber inclusion bodies (HP:0100299)3.62061503
33Increased connective tissue (HP:0009025)3.61578375
34Distal arthrogryposis (HP:0005684)3.59741433
35Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.57923994
36Round ear (HP:0100830)3.52803555
37Nemaline bodies (HP:0003798)3.43181068
38* Palmoplantar keratoderma (HP:0000982)3.31465750
39Absent hair (HP:0002298)3.22922998
40Hypohidrosis (HP:0000966)3.18803077
41Atrophic scars (HP:0001075)3.17086411
42Lip pit (HP:0100267)3.15140041
43Ridged nail (HP:0001807)3.04487676
44Follicular hyperkeratosis (HP:0007502)3.03578761
45Pruritus (HP:0000989)3.02392148
46Exercise-induced myalgia (HP:0003738)3.02036167
47Parakeratosis (HP:0001036)2.98357777
48Abnormality of hair growth rate (HP:0011363)2.97511200
49Slow-growing hair (HP:0002217)2.97511200
50Abnormal hair laboratory examination (HP:0003328)2.97369880
51Myopathic facies (HP:0002058)2.95889851
52Distal lower limb muscle weakness (HP:0009053)2.93254532
53Ulnar deviation of the wrist (HP:0003049)2.88924535
54Curly hair (HP:0002212)2.82117025
55Calcaneovalgus deformity (HP:0001848)2.75896619
56Ventricular tachycardia (HP:0004756)2.75736431
57Eczematoid dermatitis (HP:0000976)2.67190597
58Lack of skin elasticity (HP:0100679)2.66294521
59Fatigable weakness (HP:0003473)2.65581333
60Abnormality of the neuromuscular junction (HP:0003398)2.65581333
61Advanced eruption of teeth (HP:0006288)2.65459970
62Muscle fiber splitting (HP:0003555)2.61649601
63Hypergammaglobulinemia (HP:0010702)2.55473769
64Sparse eyelashes (HP:0000653)2.48769393
65Areflexia of lower limbs (HP:0002522)2.46040879
66Deformed tarsal bones (HP:0008119)2.43326030
67Absent phalangeal crease (HP:0006109)2.41940027
68Natal tooth (HP:0000695)2.36933860
69Furrowed tongue (HP:0000221)2.28381508
70Acanthosis nigricans (HP:0000956)2.27067742
71Malignant hyperthermia (HP:0002047)2.25619095
72Hypoplastic labia majora (HP:0000059)2.24283602
73Selective tooth agenesis (HP:0001592)2.22864844
74Difficulty running (HP:0009046)2.22266854
75Split foot (HP:0001839)2.19692866
76Fragile skin (HP:0001030)2.18801230
77Exercise-induced muscle cramps (HP:0003710)2.17895659
78Abnormality of skeletal muscle fiber size (HP:0012084)2.14447359
79Increased variability in muscle fiber diameter (HP:0003557)2.12619635
80Blepharitis (HP:0000498)2.06029446
81Hyperhidrosis (HP:0000975)2.04734521
82Hamartoma (HP:0010566)2.04373371
83Abnormality of permanent molar morphology (HP:0011071)2.03852863
84Abnormality of the dental root (HP:0006486)2.03852863
85Taurodontia (HP:0000679)2.03852863
86Abnormality of the labia majora (HP:0012881)2.03549573
87Aplasia involving bones of the upper limbs (HP:0009823)2.00747217
88Aplasia of the phalanges of the hand (HP:0009802)2.00747217
89Aplasia involving bones of the extremities (HP:0009825)2.00747217
90Abnormal finger flexion creases (HP:0006143)1.98699120
91Nasolacrimal duct obstruction (HP:0000579)1.98115091
92Pustule (HP:0200039)1.97788475
93Achilles tendon contracture (HP:0001771)1.96229566
94Distal lower limb amyotrophy (HP:0008944)1.95242162
95Conical tooth (HP:0000698)1.94994509
96Paralysis (HP:0003470)1.91785548
97Abnormality of molar (HP:0011077)1.91716369
98Abnormality of molar morphology (HP:0011070)1.91716369
99Dry hair (HP:0011359)1.91402585
100Sudden death (HP:0001699)1.90719514
101Xerostomia (HP:0000217)1.89614790
102Neck muscle weakness (HP:0000467)1.88799277
103Septate vagina (HP:0001153)1.85114377
104Duplicated collecting system (HP:0000081)1.85101751
105Abnormality of the dental pulp (HP:0006479)1.81106184
106Autoamputation (HP:0001218)1.80982921
107Abnormality of the Achilles tendon (HP:0005109)1.79548408
108Amniotic constriction ring (HP:0009775)1.79434358
109Abnormality of placental membranes (HP:0011409)1.79434358
110Fine hair (HP:0002213)1.79217226
111Dehydration (HP:0001944)1.77837286
112Brittle hair (HP:0002299)1.74761308
113Anonychia (HP:0001798)1.74755479
114Recurrent corneal erosions (HP:0000495)1.73421963
115Sparse scalp hair (HP:0002209)1.73259538
116Melanocytic nevus (HP:0000995)1.73218444
117Skin ulcer (HP:0200042)1.71926705
118Ventricular fibrillation (HP:0001663)1.70065735
119Depressed nasal tip (HP:0000437)1.69029809
120Frequent falls (HP:0002359)1.68780513
121Laryngomalacia (HP:0001601)1.67907233
122Dry skin (HP:0000958)1.67446403
123Verrucae (HP:0200043)1.65221006
124Papilloma (HP:0012740)1.65221006
125Mildly elevated creatine phosphokinase (HP:0008180)1.63997958
126Spinal rigidity (HP:0003306)1.62699105
127Urticaria (HP:0001025)1.61538347
128Abnormality of the calcaneus (HP:0008364)1.60521337
129Aplasia cutis congenita (HP:0001057)1.59699630
130Abnormality of the salivary glands (HP:0010286)1.59328130
131Multifactorial inheritance (HP:0001426)1.58878536
132Neonatal onset (HP:0003623)1.57462064
133Sepsis (HP:0100806)1.56799763
134Abnormality of the renal collecting system (HP:0004742)1.56714004
135Abnormality of the lacrimal duct (HP:0011481)1.55492211
136Oligodontia (HP:0000677)1.53936372
137Myoglobinuria (HP:0002913)1.51699931
138Abnormality of the fingernails (HP:0001231)1.49851567
139Difficulty climbing stairs (HP:0003551)1.49004973
140Neonatal death (HP:0003811)1.48715669
141Breast hypoplasia (HP:0003187)1.44941501
142Anhidrosis (HP:0000970)1.43704589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR16.10708370
2MAPKAPK34.78226560
3TTN4.77763306
4MST1R4.15734814
5PIK3CG3.72402381
6FER3.49026359
7OBSCN3.17773730
8MAP3K32.93329295
9ERN12.63508280
10FGFR12.45130997
11TRIB32.40222331
12TAOK12.37168370
13MAP3K22.12084472
14SGK2232.04639340
15SGK4942.04639340
16RIPK12.00499039
17MAP3K91.94045952
18MAP3K111.91321403
19MAPK71.91243921
20EPHB21.91118792
21RPS6KB21.85782504
22LATS11.82211929
23MAP2K61.79168417
24NME11.75261418
25PHKG21.73310433
26PHKG11.73310433
27EPHA21.63206058
28MAP2K31.62791281
29MAP3K71.57957894
30EEF2K1.47789999
31PRPF4B1.35083736
32MET1.34892576
33MST41.29159913
34MAP2K41.28623382
35MAP3K11.27676096
36LATS21.20099948
37TRPM71.17489129
38STK31.16773257
39FGFR21.16690322
40NLK1.06161870
41RPS6KB11.04834928
42MAPKAPK51.02749306
43NTRK21.00121003
44STK240.99697502
45NEK10.97622725
46GRK60.96506199
47SGK20.96354009
48MAP3K60.96024310
49IKBKB0.95346675
50IRAK10.95271895
51DYRK1B0.95149748
52PTK60.95045757
53KIT0.89948239
54LRRK20.89464233
55MAPKAPK20.89119873
56CDK120.87940763
57BLK0.87298301
58BCR0.86695629
59KSR20.83806825
60ERBB30.83059451
61EPHB10.82893738
62FGFR40.79917715
63MAPK120.77910437
64MAP2K10.77792898
65DMPK0.77623213
66WNK10.72869021
67CDK60.72494893
68SGK30.72173143
69PRKD10.70952352
70RPS6KA40.70708995
71BMX0.68779631
72PKN20.68485441
73EPHA30.67509870
74TYRO30.65364962
75SIK10.65356404
76PRKCI0.62876881
77MINK10.58833584
78ADRBK10.58037963
79DDR20.56957935
80FGFR30.54204726
81MARK20.53429319
82MTOR0.51013843
83MAP3K120.50789473
84TIE10.48822852
85STK38L0.48636202
86ICK0.47190768
87PTK20.46335365
88ILK0.46074044
89PRKCE0.45656962
90TYK20.45157029
91AKT30.43396562
92FRK0.43058895
93PDGFRA0.43015560
94EPHA40.42998160
95TGFBR20.42952126
96PAK30.42914987
97PRKD20.42312742
98MAPK110.41661655
99PDK30.41342065
100PDK40.41342065
101FGR0.40568468
102TAOK20.37473449
103RPS6KA20.36776609
104TESK10.35510209
105BRD40.35119320
106PBK0.34107588
107STK110.33406962
108PKN10.31740879
109LIMK10.31025594
110JAK30.29579687
111RPS6KA10.29271569
112HIPK20.28796615
113ERBB20.28127940
114MAP3K50.26069994
115MYLK0.25582326
116PIM20.25225623
117ABL20.24698794
118ABL10.24550826
119PRKCH0.24199783
120ROCK20.23646808
121CDC42BPA0.23473746
122MAP2K20.23390970
123GRK70.23197181
124ROCK10.22422566
125PDGFRB0.21998272
126STK380.21992999
127CDK30.21283468
128IRAK20.19715376
129SGK10.19179553
130TAOK30.18890373
131MOS0.18237496
132RET0.18231994
133STK100.17832470
134PDK20.17486814
135MAPK40.17327626
136PRKAA20.17283585
137CSNK1D0.16357262
138TAF10.16016133
139GSK3A0.15618340
140RIPK40.15244068
141PRKACA0.14332577
142MAPK90.13934095

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.18085206
2Linoleic acid metabolism_Homo sapiens_hsa005913.16860153
3Fatty acid elongation_Homo sapiens_hsa000622.90368787
4Arachidonic acid metabolism_Homo sapiens_hsa005902.39016181
5Fat digestion and absorption_Homo sapiens_hsa049752.33378289
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.22481660
7Phenylalanine metabolism_Homo sapiens_hsa003602.16603166
8Basal cell carcinoma_Homo sapiens_hsa052172.09005326
9Sphingolipid metabolism_Homo sapiens_hsa006001.95026789
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.84971086
11VEGF signaling pathway_Homo sapiens_hsa043701.81658324
12Ovarian steroidogenesis_Homo sapiens_hsa049131.81319625
13Histidine metabolism_Homo sapiens_hsa003401.75685532
14Ether lipid metabolism_Homo sapiens_hsa005651.70465879
15GnRH signaling pathway_Homo sapiens_hsa049121.67934387
16Staphylococcus aureus infection_Homo sapiens_hsa051501.58507391
17Tight junction_Homo sapiens_hsa045301.58418863
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54274954
19Salivary secretion_Homo sapiens_hsa049701.53810893
20Hedgehog signaling pathway_Homo sapiens_hsa043401.50592205
21ECM-receptor interaction_Homo sapiens_hsa045121.42511525
22Renin secretion_Homo sapiens_hsa049241.37948916
23Melanogenesis_Homo sapiens_hsa049161.37240719
24Axon guidance_Homo sapiens_hsa043601.34612590
25Vascular smooth muscle contraction_Homo sapiens_hsa042701.24649374
26Proteoglycans in cancer_Homo sapiens_hsa052051.22992282
27Choline metabolism in cancer_Homo sapiens_hsa052311.22567304
28Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22504675
29ABC transporters_Homo sapiens_hsa020101.21036422
30Gastric acid secretion_Homo sapiens_hsa049711.12836360
31Adherens junction_Homo sapiens_hsa045201.12682164
32Long-term depression_Homo sapiens_hsa047301.11636227
33Amoebiasis_Homo sapiens_hsa051461.10053932
34Oxytocin signaling pathway_Homo sapiens_hsa049211.09209686
35Hippo signaling pathway_Homo sapiens_hsa043901.07254818
36Vitamin digestion and absorption_Homo sapiens_hsa049771.06104099
37Tyrosine metabolism_Homo sapiens_hsa003501.04653034
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.00803972
39Long-term potentiation_Homo sapiens_hsa047200.98035114
40Bladder cancer_Homo sapiens_hsa052190.96108895
41Pancreatic secretion_Homo sapiens_hsa049720.95527606
42Phototransduction_Homo sapiens_hsa047440.91111265
43Protein digestion and absorption_Homo sapiens_hsa049740.90650980
44Insulin resistance_Homo sapiens_hsa049310.90190729
45Glioma_Homo sapiens_hsa052140.89751505
46Dilated cardiomyopathy_Homo sapiens_hsa054140.89706247
47Sphingolipid signaling pathway_Homo sapiens_hsa040710.89605819
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89603329
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89114020
50Fatty acid biosynthesis_Homo sapiens_hsa000610.87039395
51Ras signaling pathway_Homo sapiens_hsa040140.83232069
52Acute myeloid leukemia_Homo sapiens_hsa052210.83066602
53Pertussis_Homo sapiens_hsa051330.81855414
54Serotonergic synapse_Homo sapiens_hsa047260.81687492
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79871484
56Platelet activation_Homo sapiens_hsa046110.79637032
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.79347757
58Focal adhesion_Homo sapiens_hsa045100.78941294
59Steroid biosynthesis_Homo sapiens_hsa001000.78569031
60Calcium signaling pathway_Homo sapiens_hsa040200.78109620
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77309672
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.76122276
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75529674
64ErbB signaling pathway_Homo sapiens_hsa040120.75143714
65Estrogen signaling pathway_Homo sapiens_hsa049150.73685084
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72132325
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71697456
68Dorso-ventral axis formation_Homo sapiens_hsa043200.68798368
69Toxoplasmosis_Homo sapiens_hsa051450.68200294
70Glutamatergic synapse_Homo sapiens_hsa047240.66229153
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66047059
72beta-Alanine metabolism_Homo sapiens_hsa004100.65983516
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65370797
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.64457613
75Rap1 signaling pathway_Homo sapiens_hsa040150.64372064
76Thyroid cancer_Homo sapiens_hsa052160.63262236
77PPAR signaling pathway_Homo sapiens_hsa033200.61039092
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.60712454
79Glycerolipid metabolism_Homo sapiens_hsa005610.60670506
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59971115
81Glucagon signaling pathway_Homo sapiens_hsa049220.59196785
82Insulin signaling pathway_Homo sapiens_hsa049100.58845236
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58477571
84Wnt signaling pathway_Homo sapiens_hsa043100.58299150
85Tuberculosis_Homo sapiens_hsa051520.57394534
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.56816736
87MicroRNAs in cancer_Homo sapiens_hsa052060.55575013
88Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55380849
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54525657
90Inositol phosphate metabolism_Homo sapiens_hsa005620.54005524
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53961292
92Chemical carcinogenesis_Homo sapiens_hsa052040.53142069
93Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53004291
94Notch signaling pathway_Homo sapiens_hsa043300.52020766
95Olfactory transduction_Homo sapiens_hsa047400.51999547
96Amphetamine addiction_Homo sapiens_hsa050310.51302179
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50448374
98MAPK signaling pathway_Homo sapiens_hsa040100.49559793
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47468038
100Non-small cell lung cancer_Homo sapiens_hsa052230.47225436
101Hepatitis C_Homo sapiens_hsa051600.47097138
102Fatty acid degradation_Homo sapiens_hsa000710.46851545
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.46692798
104Circadian entrainment_Homo sapiens_hsa047130.46640366
105p53 signaling pathway_Homo sapiens_hsa041150.46042102
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46006738
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.45102877
108Cardiac muscle contraction_Homo sapiens_hsa042600.43648216
109Renal cell carcinoma_Homo sapiens_hsa052110.42774040
110Fatty acid metabolism_Homo sapiens_hsa012120.42023755
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41408459
112Circadian rhythm_Homo sapiens_hsa047100.41397750
113Retinol metabolism_Homo sapiens_hsa008300.40821787
114Dopaminergic synapse_Homo sapiens_hsa047280.39496491
115Endocytosis_Homo sapiens_hsa041440.38036837
116Nitrogen metabolism_Homo sapiens_hsa009100.30651793
117Arginine biosynthesis_Homo sapiens_hsa002200.29273050
118cAMP signaling pathway_Homo sapiens_hsa040240.27524680
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26523426
120Pathways in cancer_Homo sapiens_hsa052000.24347693
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23458259
122Pancreatic cancer_Homo sapiens_hsa052120.22604446
123Collecting duct acid secretion_Homo sapiens_hsa049660.21669415
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.20820274

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