LMTK3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.84506082
2locomotory exploration behavior (GO:0035641)6.58120199
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.52687135
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.08550586
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.87229394
6vocalization behavior (GO:0071625)5.82369998
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.59176928
8layer formation in cerebral cortex (GO:0021819)5.29382616
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.22920393
10regulation of glutamate receptor signaling pathway (GO:1900449)5.20013667
11synaptic vesicle exocytosis (GO:0016079)5.14908518
12glutamate secretion (GO:0014047)5.11421044
13regulation of synaptic vesicle exocytosis (GO:2000300)5.05034973
14exploration behavior (GO:0035640)4.93680031
15regulation of synapse structural plasticity (GO:0051823)4.92100019
16dendritic spine morphogenesis (GO:0060997)4.90922525
17regulation of neuronal synaptic plasticity (GO:0048168)4.87382223
18protein localization to synapse (GO:0035418)4.84250603
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.79369910
20cerebellar granule cell differentiation (GO:0021707)4.65495509
21ionotropic glutamate receptor signaling pathway (GO:0035235)4.65216984
22neurotransmitter secretion (GO:0007269)4.58142822
23regulation of synaptic vesicle transport (GO:1902803)4.46134419
24L-amino acid import (GO:0043092)4.43343332
25gamma-aminobutyric acid transport (GO:0015812)4.37830135
26neuron cell-cell adhesion (GO:0007158)4.37138604
27neurotransmitter-gated ion channel clustering (GO:0072578)4.30502804
28amino acid import (GO:0043090)4.15834635
29synaptic transmission, glutamatergic (GO:0035249)4.12260386
30proline transport (GO:0015824)4.07482491
31neuromuscular process controlling balance (GO:0050885)4.05362117
32positive regulation of membrane potential (GO:0045838)4.01089209
33auditory behavior (GO:0031223)4.00021529
34regulation of dendritic spine morphogenesis (GO:0061001)3.96742581
35positive regulation of synapse maturation (GO:0090129)3.96503408
36long-term memory (GO:0007616)3.95663278
37potassium ion homeostasis (GO:0055075)3.95463663
38sodium ion export (GO:0071436)3.93997341
39glutamate receptor signaling pathway (GO:0007215)3.89939487
40neuronal action potential propagation (GO:0019227)3.87438933
41cytoskeletal anchoring at plasma membrane (GO:0007016)3.83780464
42cellular potassium ion homeostasis (GO:0030007)3.83425264
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.83272754
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.82300930
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.76841089
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.76758873
47central nervous system myelination (GO:0022010)3.76539034
48axon ensheathment in central nervous system (GO:0032291)3.76539034
49positive regulation of synaptic transmission, GABAergic (GO:0032230)3.74251960
50dendrite morphogenesis (GO:0048813)3.73228430
51activation of protein kinase A activity (GO:0034199)3.70985544
52neuron-neuron synaptic transmission (GO:0007270)3.68950924
53glycine transport (GO:0015816)3.65332038
54neuron recognition (GO:0008038)3.65231440
55regulation of synaptic plasticity (GO:0048167)3.61785654
56positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.61129773
57response to auditory stimulus (GO:0010996)3.59816612
58prepulse inhibition (GO:0060134)3.57534808
59neuronal ion channel clustering (GO:0045161)3.56204636
60regulation of postsynaptic membrane potential (GO:0060078)3.55127144
61neurotransmitter transport (GO:0006836)3.55060582
62axonal fasciculation (GO:0007413)3.52877216
63postsynaptic membrane organization (GO:0001941)3.52753880
64potassium ion import (GO:0010107)3.50220067
65cell communication by electrical coupling (GO:0010644)3.46793546
66transmission of nerve impulse (GO:0019226)3.45656424
67negative regulation of dendrite morphogenesis (GO:0050774)3.45523877
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44911125
69dendritic spine organization (GO:0097061)3.44512492
70establishment of mitochondrion localization (GO:0051654)3.44172122
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42046394
72G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.41888658
73synaptic vesicle endocytosis (GO:0048488)3.40806960
74positive regulation of dendritic spine development (GO:0060999)3.39337540
75cerebellar Purkinje cell layer development (GO:0021680)3.36017626
76regulation of neurotransmitter secretion (GO:0046928)3.35769888
77regulation of ARF protein signal transduction (GO:0032012)3.35575456
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35337219
79cerebellar Purkinje cell differentiation (GO:0021702)3.35241228
80cell migration in hindbrain (GO:0021535)3.34865955
81regulation of voltage-gated calcium channel activity (GO:1901385)3.33802170
82regulation of neurotransmitter levels (GO:0001505)3.32537677
83positive regulation of dendritic spine morphogenesis (GO:0061003)3.31137478
84positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29210197
85cellular sodium ion homeostasis (GO:0006883)3.28776028
86regulation of dendritic spine development (GO:0060998)3.25213617
87regulation of synaptic transmission, glutamatergic (GO:0051966)3.22641251
88positive regulation of neurotransmitter secretion (GO:0001956)3.20603239
89mating behavior (GO:0007617)3.16699576
90neuromuscular process controlling posture (GO:0050884)3.16418309
91positive regulation of neurotransmitter transport (GO:0051590)3.16102762
92adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.14735674
93neuromuscular process (GO:0050905)3.11337602
94regulation of female receptivity (GO:0045924)3.11262431
95regulation of vesicle fusion (GO:0031338)3.10289481
96intraspecies interaction between organisms (GO:0051703)3.10148804
97social behavior (GO:0035176)3.10148804
98regulation of neurotransmitter transport (GO:0051588)3.10049803
99establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.09728592
100mitochondrion transport along microtubule (GO:0047497)3.09728592
101vesicle transport along microtubule (GO:0047496)3.09646941
102central nervous system projection neuron axonogenesis (GO:0021952)3.07891289
103learning (GO:0007612)3.06796889
104positive regulation of dendrite development (GO:1900006)3.05061293
105presynaptic membrane organization (GO:0097090)3.04107574
106membrane depolarization (GO:0051899)3.03332880
107establishment of nucleus localization (GO:0040023)3.03029481
108long-term synaptic potentiation (GO:0060291)3.00917388
109membrane hyperpolarization (GO:0060081)3.00628672
110dopamine receptor signaling pathway (GO:0007212)2.99731647
111membrane depolarization during action potential (GO:0086010)2.98737414
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96911201
113neuromuscular synaptic transmission (GO:0007274)2.96671415
114presynaptic membrane assembly (GO:0097105)2.96650409
115synapse assembly (GO:0007416)2.96559347
116mechanosensory behavior (GO:0007638)2.95427189
117cell differentiation in hindbrain (GO:0021533)2.94412666
118regulation of dendrite morphogenesis (GO:0048814)2.94233931
119regulation of synaptic transmission (GO:0050804)2.93337890
120cell communication involved in cardiac conduction (GO:0086065)2.93300918
121regulation of synapse maturation (GO:0090128)2.92984386
122positive regulation of synaptic transmission (GO:0050806)2.91832859
123clathrin coat assembly (GO:0048268)2.91337234
124organelle transport along microtubule (GO:0072384)2.89974962
125innervation (GO:0060384)2.88971700

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.82566858
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.08033243
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01268448
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98740619
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91300969
6REST_21632747_ChIP-Seq_MESCs_Mouse2.89026635
7DROSHA_22980978_ChIP-Seq_HELA_Human2.87754710
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.76726029
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.76726029
10* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.76081412
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67243433
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.61094415
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56892097
14GBX2_23144817_ChIP-Seq_PC3_Human2.55554559
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53510845
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.50547637
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43558444
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.41747782
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.41604572
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.41012658
21CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39429200
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39069466
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37163345
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36857385
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.31363630
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26130873
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11337661
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.08315128
29* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.06529862
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.93594174
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.75110897
32* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72243145
33AR_21572438_ChIP-Seq_LNCaP_Human1.70599535
34* KDM2B_26808549_Chip-Seq_K562_Human1.66503432
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64364502
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63701338
37RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.56620234
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55152145
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52601530
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.52371290
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.47976179
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.39091859
43P68_20966046_ChIP-Seq_HELA_Human1.37196123
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35995061
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.34286896
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33626196
47WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32295721
48* CREB1_26743006_Chip-Seq_LNCaP_Human1.29822885
49CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28971192
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28020073
51GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26710079
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25216821
53ZNF274_21170338_ChIP-Seq_K562_Hela1.23553298
54AR_19668381_ChIP-Seq_PC3_Human1.22842487
55TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22378707
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22070295
57* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22051563
58RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21813697
59RACK7_27058665_Chip-Seq_MCF-7_Human1.19455031
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.19011294
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18788432
62SMAD4_21799915_ChIP-Seq_A2780_Human1.18549328
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18359295
64TET1_21451524_ChIP-Seq_MESCs_Mouse1.17591809
65* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16624770
66PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.13884322
67* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11964792
68CTCF_27219007_Chip-Seq_Bcells_Human1.09600187
69TCF7_22412390_ChIP-Seq_EML_Mouse1.09228731
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08380051
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08095533
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07438224
73TET1_21490601_ChIP-Seq_MESCs_Mouse1.06919186
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05983269
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.05903629
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.04951759
77MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04880365
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03202209
79SA1_27219007_Chip-Seq_ERYTHROID_Human1.03201165
80NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03002202
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02220144
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02036179
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.00935973
84ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00499425
85LXR_22292898_ChIP-Seq_THP-1_Human0.99744242
86YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99328117
87KDM2B_26808549_Chip-Seq_DND41_Human0.98583198
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98386417
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98204667
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98050193
91CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97520282
92ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96237824
93STAT3_23295773_ChIP-Seq_U87_Human0.96036696
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.94003419
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.93951865
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.92038286
97* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91918367
98SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.91210081
99AR_25329375_ChIP-Seq_VCAP_Human0.90983647
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90184265
101DPY_21335234_ChIP-Seq_ESCs_Mouse0.90011286
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.89939045
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88794863
104CBX2_27304074_Chip-Seq_ESCs_Mouse0.87887822
105KLF4_19829295_ChIP-Seq_ESCs_Human0.87631783
106SMC4_20622854_ChIP-Seq_HELA_Human0.87487994
107TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.86129668
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85695005
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.85650133
110TP53_23651856_ChIP-Seq_MEFs_Mouse0.85428400
111AHR_22903824_ChIP-Seq_MCF-7_Human0.85404175
112* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85288986
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83386433
114TP53_20018659_ChIP-ChIP_R1E_Mouse0.82447253
115OCT4_19829295_ChIP-Seq_ESCs_Human0.82313709
116TCF4_23295773_ChIP-Seq_U87_Human0.82181736
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82054552
118SMAD_19615063_ChIP-ChIP_OVARY_Human0.81989888
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81477263
120RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81116875
121NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79027344
122* SMAD4_21741376_ChIP-Seq_ESCs_Human0.78754731
123RXR_22108803_ChIP-Seq_LS180_Human0.78725119
124RNF2_27304074_Chip-Seq_NSC_Mouse0.78659627
125* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.78472667
126NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78463164
127SA1_27219007_Chip-Seq_Bcells_Human0.78235390
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77295127
129* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.76942954
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.76277914
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76038639
132POU5F1_16518401_ChIP-PET_MESCs_Mouse0.76038631
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74554268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.42754404
2MP0003635_abnormal_synaptic_transmissio4.34019439
3MP0003880_abnormal_central_pattern4.29411045
4MP0004270_analgesia3.91252016
5MP0002063_abnormal_learning/memory/cond3.48017193
6MP0005423_abnormal_somatic_nervous3.40530362
7MP0009745_abnormal_behavioral_response3.40122338
8MP0002822_catalepsy3.29902415
9MP0002064_seizures3.09150237
10MP0009046_muscle_twitch2.93222701
11MP0002572_abnormal_emotion/affect_behav2.70086615
12MP0002734_abnormal_mechanical_nocicepti2.61824219
13MP0001968_abnormal_touch/_nociception2.58702224
14MP0001486_abnormal_startle_reflex2.55626968
15MP0002272_abnormal_nervous_system2.34595211
16MP0009780_abnormal_chondrocyte_physiolo2.31457948
17MP0004858_abnormal_nervous_system2.12645274
18MP0001501_abnormal_sleep_pattern2.06245796
19MP0004811_abnormal_neuron_physiology2.06174474
20MP0000778_abnormal_nervous_system2.05246053
21MP0002733_abnormal_thermal_nociception2.02847234
22MP0002909_abnormal_adrenal_gland2.01949451
23MP0008569_lethality_at_weaning1.99656416
24MP0003123_paternal_imprinting1.95073501
25MP0003329_amyloid_beta_deposits1.94153251
26MP0001440_abnormal_grooming_behavior1.91420937
27MP0001970_abnormal_pain_threshold1.89777595
28MP0002184_abnormal_innervation1.81884797
29MP0004885_abnormal_endolymph1.80271713
30MP0002557_abnormal_social/conspecific_i1.79366745
31MP0000955_abnormal_spinal_cord1.77230237
32MP0002735_abnormal_chemical_nociception1.75853166
33MP0002736_abnormal_nociception_after1.75405917
34MP0002067_abnormal_sensory_capabilities1.70967552
35MP0004924_abnormal_behavior1.66334893
36MP0005386_behavior/neurological_phenoty1.66334893
37MP0003879_abnormal_hair_cell1.60071889
38MP0003283_abnormal_digestive_organ1.55120980
39MP0005646_abnormal_pituitary_gland1.52655029
40MP0002882_abnormal_neuron_morphology1.48968177
41MP0003787_abnormal_imprinting1.47447304
42MP0002066_abnormal_motor_capabilities/c1.44586564
43MP0005645_abnormal_hypothalamus_physiol1.39880479
44MP0003633_abnormal_nervous_system1.37870470
45MP0001984_abnormal_olfaction1.35196070
46MP0000569_abnormal_digit_pigmentation1.34925029
47MP0008961_abnormal_basal_metabolism1.30269667
48MP0002152_abnormal_brain_morphology1.25218643
49MP0000579_abnormal_nail_morphology1.16853286
50MP0001502_abnormal_circadian_rhythm1.15934335
51MP0003631_nervous_system_phenotype1.14750592
52MP0003075_altered_response_to1.12889828
53MP0005409_darkened_coat_color1.10023860
54MP0006276_abnormal_autonomic_nervous1.07963964
55MP0003122_maternal_imprinting1.06003194
56MP0000566_synostosis1.05790569
57MP0001177_atelectasis1.04432956
58MP0004142_abnormal_muscle_tone1.02908380
59MP0002069_abnormal_eating/drinking_beha1.00922750
60MP0008872_abnormal_physiological_respon0.95910188
61MP0003690_abnormal_glial_cell0.95850900
62MP0005499_abnormal_olfactory_system0.95410045
63MP0005394_taste/olfaction_phenotype0.95410045
64MP0001529_abnormal_vocalization0.92942034
65MP0001346_abnormal_lacrimal_gland0.91489313
66MP0003634_abnormal_glial_cell0.90087546
67MP0008874_decreased_physiological_sensi0.90000001
68MP0005167_abnormal_blood-brain_barrier0.88960022
69MP0002229_neurodegeneration0.87657104
70MP0001905_abnormal_dopamine_level0.86689610
71MP0002249_abnormal_larynx_morphology0.86566374
72MP0000751_myopathy0.86080816
73MP0003632_abnormal_nervous_system0.85392105
74MP0000013_abnormal_adipose_tissue0.84511998
75MP0000604_amyloidosis0.83660208
76MP0000631_abnormal_neuroendocrine_gland0.83656587
77MP0004085_abnormal_heartbeat0.80199094
78MP0003172_abnormal_lysosome_physiology0.79894739
79MP0003121_genomic_imprinting0.79636584
80MP0000920_abnormal_myelination0.79296111
81MP0004145_abnormal_muscle_electrophysio0.79048957
82MP0002653_abnormal_ependyma_morphology0.78086603
83MP0003861_abnormal_nervous_system0.77390214
84MP0010234_abnormal_vibrissa_follicle0.77163217
85MP0003137_abnormal_impulse_conducting0.75593799
86MP0004233_abnormal_muscle_weight0.72313292
87MP0005623_abnormal_meninges_morphology0.70395754
88MP0005187_abnormal_penis_morphology0.69573473
89MP0005535_abnormal_body_temperature0.69505016
90MP0001348_abnormal_lacrimal_gland0.69492454
91MP0002752_abnormal_somatic_nervous0.68523434
92MP0002090_abnormal_vision0.66789628
93MP0004742_abnormal_vestibular_system0.66078484
94MP0003705_abnormal_hypodermis_morpholog0.63820132
95MP0002089_abnormal_postnatal_growth/wei0.62842142
96MP0001963_abnormal_hearing_physiology0.62672978
97MP0001485_abnormal_pinna_reflex0.62573211
98MP0002638_abnormal_pupillary_reflex0.61812625
99MP0010769_abnormal_survival0.60687044
100MP0001299_abnormal_eye_distance/0.59984537
101MP0005551_abnormal_eye_electrophysiolog0.59712754
102MP0002234_abnormal_pharynx_morphology0.58564751
103MP0004510_myositis0.57728946
104MP0001943_abnormal_respiration0.57563864
105MP0000026_abnormal_inner_ear0.56883036
106MP0010770_preweaning_lethality0.56748702
107MP0002082_postnatal_lethality0.56748702
108MP0010768_mortality/aging0.56741691
109MP0003938_abnormal_ear_development0.56339137
110MP0004130_abnormal_muscle_cell0.54953667
111MP0001188_hyperpigmentation0.54058888
112MP0002081_perinatal_lethality0.52240361
113MP0003956_abnormal_body_size0.52131356
114MP0001731_abnormal_postnatal_growth0.50991872
115MP0000537_abnormal_urethra_morphology0.49601769
116MP0002873_normal_phenotype0.48961807
117MP0002169_no_abnormal_phenotype0.47863021

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.22869373
2Focal motor seizures (HP:0011153)6.10420417
3Focal seizures (HP:0007359)5.22885773
4Visual hallucinations (HP:0002367)5.12746113
5Supranuclear gaze palsy (HP:0000605)4.07924199
6Epileptic encephalopathy (HP:0200134)4.07412037
7Ankle clonus (HP:0011448)4.03649089
8Action tremor (HP:0002345)3.95040497
9Progressive cerebellar ataxia (HP:0002073)3.90144312
10Mutism (HP:0002300)3.69855687
11Poor eye contact (HP:0000817)3.55544036
12Papilledema (HP:0001085)3.54458337
13Abnormality of the lower motor neuron (HP:0002366)3.52578746
14Depression (HP:0000716)3.38097774
15Impaired vibration sensation in the lower limbs (HP:0002166)3.37299273
16Febrile seizures (HP:0002373)3.35106335
17Urinary bladder sphincter dysfunction (HP:0002839)3.33405996
18Generalized tonic-clonic seizures (HP:0002069)3.29344832
19Broad-based gait (HP:0002136)3.26767681
20Absence seizures (HP:0002121)3.26628778
21Impaired social interactions (HP:0000735)3.24075378
22Abnormal social behavior (HP:0012433)3.24075378
23Atonic seizures (HP:0010819)3.21230231
24Genetic anticipation (HP:0003743)3.11775583
25Torticollis (HP:0000473)3.11556106
26Postural instability (HP:0002172)3.11153038
27Insomnia (HP:0100785)3.02384735
28Dialeptic seizures (HP:0011146)2.96195943
29Dysdiadochokinesis (HP:0002075)2.91549841
30Anxiety (HP:0000739)2.90078384
31Abnormal eating behavior (HP:0100738)2.89394820
32Urinary urgency (HP:0000012)2.86925587
33Gaze-evoked nystagmus (HP:0000640)2.83874048
34Dysmetria (HP:0001310)2.82869191
35Focal dystonia (HP:0004373)2.82342669
36Hemiparesis (HP:0001269)2.78339886
37Megalencephaly (HP:0001355)2.76069400
38Hemiplegia (HP:0002301)2.75996148
39Annular pancreas (HP:0001734)2.74745979
40Pointed chin (HP:0000307)2.73825610
41Spastic gait (HP:0002064)2.72942942
42Cerebral hypomyelination (HP:0006808)2.68216687
43Amyotrophic lateral sclerosis (HP:0007354)2.67884799
44Neurofibrillary tangles (HP:0002185)2.67790346
45Intention tremor (HP:0002080)2.67213632
46Sleep apnea (HP:0010535)2.66714849
47Impaired smooth pursuit (HP:0007772)2.62320780
48Cerebral inclusion bodies (HP:0100314)2.60559993
49Stereotypic behavior (HP:0000733)2.59767996
50Truncal ataxia (HP:0002078)2.57805000
51Obstructive sleep apnea (HP:0002870)2.55647617
52Amblyopia (HP:0000646)2.55597878
53Drooling (HP:0002307)2.55407540
54Excessive salivation (HP:0003781)2.55407540
55Turricephaly (HP:0000262)2.54270859
56Ventricular fibrillation (HP:0001663)2.54219499
57Craniofacial dystonia (HP:0012179)2.52781804
58Peripheral hypomyelination (HP:0007182)2.49519544
59Abnormality of binocular vision (HP:0011514)2.49227472
60Diplopia (HP:0000651)2.49227472
61Bradykinesia (HP:0002067)2.48977141
62Abnormality of the corticospinal tract (HP:0002492)2.45810940
63Aplasia involving bones of the extremities (HP:0009825)2.44027672
64Aplasia involving bones of the upper limbs (HP:0009823)2.44027672
65Aplasia of the phalanges of the hand (HP:0009802)2.44027672
66Abnormality of ocular smooth pursuit (HP:0000617)2.33660874
67Lower limb muscle weakness (HP:0007340)2.33239768
68Hyperacusis (HP:0010780)2.32408235
69Apathy (HP:0000741)2.32283968
70Delusions (HP:0000746)2.32238403
71Limb dystonia (HP:0002451)2.31631095
72Bronchomalacia (HP:0002780)2.27411477
73Progressive inability to walk (HP:0002505)2.25085445
74Termporal pattern (HP:0011008)2.23115850
75Insidious onset (HP:0003587)2.23115850
76Ankyloglossia (HP:0010296)2.23088946
77Clonus (HP:0002169)2.23021495
78Lower limb amyotrophy (HP:0007210)2.19475786
79Spastic tetraparesis (HP:0001285)2.18779033
80Impaired vibratory sensation (HP:0002495)2.18169734
81Dysmetric saccades (HP:0000641)2.15139660
82EEG with generalized epileptiform discharges (HP:0011198)2.14886150
83Epileptiform EEG discharges (HP:0011182)2.14319732
84Scanning speech (HP:0002168)2.13591469
85Hypsarrhythmia (HP:0002521)2.12313024
86Inappropriate behavior (HP:0000719)2.09218759
87Elfin facies (HP:0004428)2.09029155
88Bundle branch block (HP:0011710)2.08919611
89Agitation (HP:0000713)2.05528063
90Diminished motivation (HP:0000745)2.04612701
91Upper limb amyotrophy (HP:0009129)2.02855727
92Distal upper limb amyotrophy (HP:0007149)2.02855727
93Spinal canal stenosis (HP:0003416)2.02703526
94Fetal akinesia sequence (HP:0001989)2.01550259
95Hyperventilation (HP:0002883)2.00259307
96Status epilepticus (HP:0002133)1.99656656
97Neuronal loss in central nervous system (HP:0002529)1.98079669
98Polyphagia (HP:0002591)1.95840310
99Morphological abnormality of the pyramidal tract (HP:0002062)1.93309869
100Resting tremor (HP:0002322)1.92724337
101Hand muscle atrophy (HP:0009130)1.90910409
102Overriding aorta (HP:0002623)1.90261092
103Hyperthyroidism (HP:0000836)1.89559262
104Choreoathetosis (HP:0001266)1.87227282
105Abnormal EKG (HP:0003115)1.85835130
106Tetraplegia (HP:0002445)1.84120376
107Macroorchidism (HP:0000053)1.83222696
108Akinesia (HP:0002304)1.82828411
109Incomplete penetrance (HP:0003829)1.82729116
110Generalized myoclonic seizures (HP:0002123)1.80316291
111Lower limb asymmetry (HP:0100559)1.80208635
112Neoplasm of the heart (HP:0100544)1.79687984
113Aqueductal stenosis (HP:0002410)1.78749686
114Rapidly progressive (HP:0003678)1.78549188
115Intellectual disability, profound (HP:0002187)1.77473154
116Rigidity (HP:0002063)1.76477228
117Hammertoe (HP:0001765)1.76300219
118Absent speech (HP:0001344)1.74916256
119Hypercortisolism (HP:0001578)1.72012535
120Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68385315
121CNS hypomyelination (HP:0003429)1.65682834

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.34863482
2EPHA44.27734364
3MAP3K94.26781572
4NTRK33.94524792
5MINK12.73902479
6DAPK22.73270733
7PRKD32.65467209
8PAK62.63573475
9MAP3K42.51043603
10NTRK22.41439835
11CAMKK12.21820235
12KSR22.18065367
13NTRK11.92490172
14MAP2K71.79154298
15SIK21.75827758
16KSR11.71481737
17TYRO31.70358125
18CDK51.65077853
19TAOK11.59040687
20STK381.49083567
21MAP2K41.46100415
22DAPK11.45224548
23LATS21.38950214
24UHMK11.32427517
25PHKG21.31124426
26PHKG11.31124426
27ALK1.30966968
28TNIK1.23243837
29MAPK131.22888446
30PRPF4B1.19605450
31MAP3K21.17022871
32RIPK11.15515768
33RIPK41.12578490
34FES1.11039348
35PRKCG1.08283945
36STK111.08015809
37GRK51.06913344
38SIK11.02784023
39PRKCH1.02606217
40CDK150.99125708
41CDK180.97702018
42PLK20.96461390
43MARK20.96366233
44CAMK10.92244547
45CDK140.90428961
46CDK190.89303293
47ICK0.88635410
48RET0.87438137
49CDK11A0.87363917
50MAP3K120.86876730
51MAP3K130.84760833
52MAPK120.84673440
53PNCK0.83351608
54CAMK2G0.82427211
55BRAF0.80787852
56PAK30.79894704
57SGK2230.75794485
58SGK4940.75794485
59LMTK20.74947008
60CAMKK20.73767878
61SCYL20.71519981
62ARAF0.71373350
63PINK10.69816946
64BRSK10.69293532
65CAMK2A0.69235809
66CSNK1G20.69077882
67RAF10.67307191
68SGK30.67286400
69CDC42BPA0.66702189
70NEK10.66501197
71DYRK1A0.65914809
72SGK10.65227320
73MAP3K110.64369660
74TESK10.64228135
75TRIB30.63527930
76PRKCZ0.62031961
77CAMK1G0.61807029
78EEF2K0.61786005
79PDK10.60281606
80DDR20.57954010
81RPS6KA30.55829163
82PDPK10.54386920
83FYN0.53700823
84PDGFRA0.53696620
85SGK20.53252521
86MAP3K70.51395661
87ROCK20.50151472
88TNK20.49649709
89CAMK2B0.49490027
90MAPK100.49414949
91CAMK40.48227652
92ERBB30.47555274
93MAP3K10.46843405
94RPS6KA20.45783225
95PRKG20.45446665
96NEK60.42838791
97CAMK1D0.40618849
98FGFR20.40571059
99DMPK0.39729686
100BMX0.39663732
101SMG10.39118760
102PTK2B0.38867727
103CAMK2D0.38863621
104IRAK20.38743744
105DAPK30.37981249
106ERBB20.37206731
107CDK120.36998418
108DYRK20.36352446
109LIMK10.35916711
110CASK0.35421036
111MAPK80.34191789
112WNK10.33561673
113ROCK10.33477553
114MAP2K60.31809708
115PRKCB0.30316965
116PRKD20.30305202
117PKN10.30174371
118MAP2K10.28649345

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.16837185
2Synaptic vesicle cycle_Homo sapiens_hsa047213.10042113
3Olfactory transduction_Homo sapiens_hsa047402.84290407
4Circadian entrainment_Homo sapiens_hsa047132.65271016
5GABAergic synapse_Homo sapiens_hsa047272.63040769
6Glutamatergic synapse_Homo sapiens_hsa047242.51645239
7Long-term potentiation_Homo sapiens_hsa047202.51327622
8Morphine addiction_Homo sapiens_hsa050322.36532770
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.33960996
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.33029625
11Amphetamine addiction_Homo sapiens_hsa050312.30581368
12Dopaminergic synapse_Homo sapiens_hsa047282.11636783
13Salivary secretion_Homo sapiens_hsa049702.05144531
14Cholinergic synapse_Homo sapiens_hsa047251.96558478
15Insulin secretion_Homo sapiens_hsa049111.95446959
16Gastric acid secretion_Homo sapiens_hsa049711.89460703
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89397069
18Cocaine addiction_Homo sapiens_hsa050301.76357596
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76284546
20Oxytocin signaling pathway_Homo sapiens_hsa049211.64139258
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.55463218
22Nitrogen metabolism_Homo sapiens_hsa009101.54275855
23Long-term depression_Homo sapiens_hsa047301.53719525
24Renin secretion_Homo sapiens_hsa049241.51986792
25Vitamin B6 metabolism_Homo sapiens_hsa007501.51337795
26GnRH signaling pathway_Homo sapiens_hsa049121.49638437
27Gap junction_Homo sapiens_hsa045401.44888529
28Calcium signaling pathway_Homo sapiens_hsa040201.42822801
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.42724288
30Taste transduction_Homo sapiens_hsa047421.40266070
31Type II diabetes mellitus_Homo sapiens_hsa049301.40074968
32Serotonergic synapse_Homo sapiens_hsa047261.34958085
33Glioma_Homo sapiens_hsa052141.33576157
34Axon guidance_Homo sapiens_hsa043601.33421439
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29726150
36cAMP signaling pathway_Homo sapiens_hsa040241.27478722
37Estrogen signaling pathway_Homo sapiens_hsa049151.26663229
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18628492
39ErbB signaling pathway_Homo sapiens_hsa040121.15965156
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11611708
41Melanogenesis_Homo sapiens_hsa049161.10579207
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06516014
43cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99460867
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.98582554
45Oocyte meiosis_Homo sapiens_hsa041140.95783936
46Dorso-ventral axis formation_Homo sapiens_hsa043200.93083670
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93039997
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.85879832
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.83856294
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81132322
51Endometrial cancer_Homo sapiens_hsa052130.80257684
52mTOR signaling pathway_Homo sapiens_hsa041500.79996109
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79890032
54VEGF signaling pathway_Homo sapiens_hsa043700.79314132
55Choline metabolism in cancer_Homo sapiens_hsa052310.78014315
56Thyroid hormone synthesis_Homo sapiens_hsa049180.76832498
57Pancreatic secretion_Homo sapiens_hsa049720.76635400
58MAPK signaling pathway_Homo sapiens_hsa040100.76457217
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76447291
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75974196
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75647929
62Dilated cardiomyopathy_Homo sapiens_hsa054140.74680697
63Collecting duct acid secretion_Homo sapiens_hsa049660.69203413
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68861939
65Non-small cell lung cancer_Homo sapiens_hsa052230.67554511
66Rap1 signaling pathway_Homo sapiens_hsa040150.66178208
67Endocytosis_Homo sapiens_hsa041440.65682329
68Cardiac muscle contraction_Homo sapiens_hsa042600.62439947
69Bile secretion_Homo sapiens_hsa049760.62375806
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60561042
71Ras signaling pathway_Homo sapiens_hsa040140.60153915
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.59807886
73Alcoholism_Homo sapiens_hsa050340.58869835
74Renal cell carcinoma_Homo sapiens_hsa052110.57652115
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57629759
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56012599
77Glucagon signaling pathway_Homo sapiens_hsa049220.55487471
78Type I diabetes mellitus_Homo sapiens_hsa049400.54452591
79AMPK signaling pathway_Homo sapiens_hsa041520.53577720
80Phototransduction_Homo sapiens_hsa047440.53444420
81Insulin signaling pathway_Homo sapiens_hsa049100.52991460
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52616073
83Wnt signaling pathway_Homo sapiens_hsa043100.52234857
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52233153
85Colorectal cancer_Homo sapiens_hsa052100.50992205
86Vibrio cholerae infection_Homo sapiens_hsa051100.50572433
87Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50029898
88Prion diseases_Homo sapiens_hsa050200.49575864
89Notch signaling pathway_Homo sapiens_hsa043300.48208129
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47657144
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46215074
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46030685
93Inositol phosphate metabolism_Homo sapiens_hsa005620.45937628
94Chemokine signaling pathway_Homo sapiens_hsa040620.45164603
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44432219
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43583113
97Circadian rhythm_Homo sapiens_hsa047100.37786654
98Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37610220
99Ovarian steroidogenesis_Homo sapiens_hsa049130.35159585
100Central carbon metabolism in cancer_Homo sapiens_hsa052300.34783152
101Prolactin signaling pathway_Homo sapiens_hsa049170.34522099
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33747808
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33518178
104HIF-1 signaling pathway_Homo sapiens_hsa040660.32879025
105Tight junction_Homo sapiens_hsa045300.32489672
106Hippo signaling pathway_Homo sapiens_hsa043900.31383096
107Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30717131
108Arginine biosynthesis_Homo sapiens_hsa002200.29290316
109Arginine and proline metabolism_Homo sapiens_hsa003300.26707949

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