LMOD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.36753631
2cardiac myofibril assembly (GO:0055003)8.44404631
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.88746467
4myofibril assembly (GO:0030239)7.75285014
5actin-myosin filament sliding (GO:0033275)7.64676814
6muscle filament sliding (GO:0030049)7.64676814
7positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)7.15896698
8negative regulation of potassium ion transmembrane transport (GO:1901380)7.04878972
9plasma membrane repair (GO:0001778)6.86532170
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.79717948
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.75287832
12cardiac muscle contraction (GO:0060048)6.65679377
13regulation of skeletal muscle contraction (GO:0014819)6.42315255
14actin-mediated cell contraction (GO:0070252)6.32287393
15regulation of relaxation of muscle (GO:1901077)6.30081934
16cardiac muscle cell development (GO:0055013)6.29928263
17tricarboxylic acid cycle (GO:0006099)6.29441106
18regulation of actin filament-based movement (GO:1903115)6.01341052
19regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.99909292
20response to muscle activity (GO:0014850)5.92655663
21cardiac cell development (GO:0055006)5.91208251
22actomyosin structure organization (GO:0031032)5.85732131
23sarcoplasmic reticulum calcium ion transport (GO:0070296)5.81280865
24ventricular cardiac muscle cell action potential (GO:0086005)5.58442545
25cardiac muscle tissue morphogenesis (GO:0055008)5.54278436
26bundle of His cell to Purkinje myocyte communication (GO:0086069)5.52447863
27striated muscle contraction (GO:0006941)5.51485240
28regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.50072462
29cardiac muscle hypertrophy (GO:0003300)5.49134052
30adult heart development (GO:0007512)5.48763350
31regulation of cell communication by electrical coupling (GO:0010649)5.39013427
32regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)5.38298923
33regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.29182838
34ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.26850741
35striated muscle hypertrophy (GO:0014897)5.23592247
36carnitine shuttle (GO:0006853)5.21210590
37regulation of sarcomere organization (GO:0060297)5.13377347
38skeletal muscle adaptation (GO:0043501)5.02611259
39muscle tissue morphogenesis (GO:0060415)5.01234453
40regulation of acyl-CoA biosynthetic process (GO:0050812)5.00848961
41regulation of striated muscle contraction (GO:0006942)4.94747255
42heart process (GO:0003015)4.84814822
43heart contraction (GO:0060047)4.84814822
44heart trabecula formation (GO:0060347)4.82237403
45skeletal muscle fiber development (GO:0048741)4.79578806
46actin filament-based movement (GO:0030048)4.76866966
47muscle hypertrophy (GO:0014896)4.63158967
48cell communication involved in cardiac conduction (GO:0086065)4.58580121
49response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.58267931
50regulation of coenzyme metabolic process (GO:0051196)4.55368166
51regulation of cofactor metabolic process (GO:0051193)4.55368166
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.53942773
53regulation of membrane repolarization (GO:0060306)4.53008516
54fatty acid transmembrane transport (GO:1902001)4.51845944
55myotube cell development (GO:0014904)4.50915440
56regulation of the force of heart contraction (GO:0002026)4.50109303
57muscle fiber development (GO:0048747)4.34209435
58glycogen catabolic process (GO:0005980)4.32009713
59skeletal muscle contraction (GO:0003009)4.21997062
60regulation of cardiac muscle cell contraction (GO:0086004)4.14564264
61creatine metabolic process (GO:0006600)4.12109834
62positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.10586819
63regulation of cardiac muscle contraction (GO:0055117)4.09658712
64skeletal muscle tissue development (GO:0007519)4.06055500
65glucan catabolic process (GO:0009251)4.05614531
66glucan biosynthetic process (GO:0009250)4.05435609
67glycogen biosynthetic process (GO:0005978)4.05435609
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.02212747
69regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.00575749
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96853185
71cardiac muscle cell action potential (GO:0086001)3.91396177
72cardiac muscle cell action potential involved in contraction (GO:0086002)3.90542081
73cell communication by electrical coupling (GO:0010644)3.88323417
74regulation of heart rate (GO:0002027)3.87635870
752-oxoglutarate metabolic process (GO:0006103)3.86317544
76muscle hypertrophy in response to stress (GO:0003299)3.86141011
77cardiac muscle adaptation (GO:0014887)3.86141011
78cardiac muscle hypertrophy in response to stress (GO:0014898)3.86141011
79carnitine transmembrane transport (GO:1902603)3.85708820
80NADH metabolic process (GO:0006734)3.84220975
81muscle cell cellular homeostasis (GO:0046716)3.83948281
82negative regulation of potassium ion transport (GO:0043267)3.83676510
83regulation of ATP catabolic process (GO:1903289)3.83125197
84regulation of ATPase activity (GO:0043462)3.83125197
85negative regulation of protein localization to cell surface (GO:2000009)3.82517310
86cellular polysaccharide catabolic process (GO:0044247)3.80508227
87muscle contraction (GO:0006936)3.80040058
88respiratory electron transport chain (GO:0022904)3.78943184
89ATP synthesis coupled proton transport (GO:0015986)3.76943700
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.76943700
91striated muscle cell development (GO:0055002)3.75486844
92muscle adaptation (GO:0043500)3.74094133
93relaxation of cardiac muscle (GO:0055119)3.73963521
94regulation of sulfur metabolic process (GO:0042762)3.72774778
95regulation of sequestering of triglyceride (GO:0010889)3.67836754
96electron transport chain (GO:0022900)3.67115709
97negative regulation of calcium ion transmembrane transport (GO:1903170)3.66429912
98negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.66429912
99oxygen transport (GO:0015671)3.65750963
100response to inactivity (GO:0014854)3.63893062
101oxidative phosphorylation (GO:0006119)3.63239103
102regulation of heart contraction (GO:0008016)3.62169338
103striated muscle atrophy (GO:0014891)3.60790061
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59280071
105positive regulation of cation channel activity (GO:2001259)3.58959990
106regulation of calcium ion transmembrane transport (GO:1903169)3.54666566
107regulation of calcium ion transmembrane transporter activity (GO:1901019)3.54666566
108muscle system process (GO:0003012)3.54302364
109negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.53022896
110skeletal muscle tissue regeneration (GO:0043403)3.51638637
111amino-acid betaine transport (GO:0015838)3.50923144
112carnitine transport (GO:0015879)3.50923144
113regulation of cardioblast differentiation (GO:0051890)3.50738012
114positive regulation of heart rate (GO:0010460)3.49482579
115regulation of muscle system process (GO:0090257)3.49344876
116negative regulation of striated muscle cell apoptotic process (GO:0010664)3.46346082
117striated muscle adaptation (GO:0014888)3.45986673
118negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.44948703
119cardiac conduction (GO:0061337)3.43328089
120polysaccharide catabolic process (GO:0000272)3.41995614
121muscle structure development (GO:0061061)3.40884903
122muscle organ development (GO:0007517)3.40212156
123muscle cell development (GO:0055001)3.37639202
124positive regulation of heart contraction (GO:0045823)3.37177821
125relaxation of muscle (GO:0090075)3.35189253
126muscle cell fate commitment (GO:0042693)3.34386168
127regulation of muscle contraction (GO:0006937)3.32620909
128glycogen metabolic process (GO:0005977)3.30239840
129response to caffeine (GO:0031000)3.23895209
130glucan metabolic process (GO:0044042)3.23577530
131cellular glucan metabolic process (GO:0006073)3.23577530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.49262499
2* EP300_21415370_ChIP-Seq_HL-1_Mouse4.68034705
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.21570676
4* TBX20_22328084_ChIP-Seq_HEART_Mouse4.13800604
5* TBX20_22080862_ChIP-Seq_HEART_Mouse4.13800604
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.92583283
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.64776875
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.41013211
9ZNF263_19887448_ChIP-Seq_K562_Human3.32431050
10ESR1_20079471_ChIP-ChIP_T-47D_Human3.17060766
11MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.10187775
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.86288714
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.59467202
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.40740402
15GATA4_21415370_ChIP-Seq_HL-1_Mouse2.36546722
16EZH2_22144423_ChIP-Seq_EOC_Human2.32502040
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18223114
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14693914
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.04672904
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.04559389
21CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01956409
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.99665562
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.97692267
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.84925626
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.83041652
26NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.75686413
27CLOCK_20551151_ChIP-Seq_293T_Human1.70945727
28TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61340377
29ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.51392153
30NFIB_24661679_ChIP-Seq_LUNG_Mouse1.49149641
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.41316600
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40898529
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.38209969
34PPARA_22158963_ChIP-Seq_LIVER_Mouse1.37343672
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36570783
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34111189
37LXR_22158963_ChIP-Seq_LIVER_Mouse1.31860712
38BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29272224
39CTCF_27219007_Chip-Seq_Bcells_Human1.26937783
40DROSHA_22980978_ChIP-Seq_HELA_Human1.25317228
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25090715
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24837622
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.21157197
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.21129194
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20900062
46KDM2B_26808549_Chip-Seq_DND41_Human1.20054589
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19335066
48SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17958283
49GBX2_23144817_ChIP-Seq_PC3_Human1.15873725
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15683333
51* TP63_22573176_ChIP-Seq_HFKS_Human1.12201539
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.12004886
53GATA1_22025678_ChIP-Seq_K562_Human1.09682830
54GATA1_19941826_ChIP-Seq_K562_Human1.09681421
55VDR_22108803_ChIP-Seq_LS180_Human1.07869938
56PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07868995
57LXR_22292898_ChIP-Seq_THP-1_Human1.06850299
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06503494
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.04574744
60BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03652576
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02692787
62ATF3_27146783_Chip-Seq_COLON_Human1.02031960
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.01853177
64RACK7_27058665_Chip-Seq_MCF-7_Human1.01525160
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.00569030
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.00457508
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.00061830
68AR_21572438_ChIP-Seq_LNCaP_Human0.99959474
69NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99523011
70SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98932991
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98241661
72STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97086998
73RARB_27405468_Chip-Seq_BRAIN_Mouse0.96965388
74SOX9_24532713_ChIP-Seq_HFSC_Mouse0.96128109
75CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95977765
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95460552
77SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95270672
78RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95142104
79FOXA2_19822575_ChIP-Seq_HepG2_Human0.94391919
80EZH2_27294783_Chip-Seq_NPCs_Mouse0.94074571
81P68_20966046_ChIP-Seq_HELA_Human0.91748193
82NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91434628
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91434628
84SPI1_20517297_ChIP-Seq_HL60_Human0.90741441
85ESR1_21235772_ChIP-Seq_MCF-7_Human0.89998210
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.89367527
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89311333
88STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.88346891
89OCT4_20526341_ChIP-Seq_ESCs_Human0.88023797
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.87823317
91GATA2_19941826_ChIP-Seq_K562_Human0.87676906
92CJUN_26792858_Chip-Seq_BT549_Human0.87528108
93ZNF274_21170338_ChIP-Seq_K562_Hela0.87479530
94MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86987314
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86526540
96ZFP281_18757296_ChIP-ChIP_E14_Mouse0.86156721
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.85893747
98MYC_27129775_Chip-Seq_CORNEA_Mouse0.84583677
99GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84573818
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.84231548
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.84169263
102LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83913088
103FOXH1_21741376_ChIP-Seq_ESCs_Human0.83863665
104GATA1_19941827_ChIP-Seq_MEL86_Mouse0.83805715
105EZH2_27304074_Chip-Seq_ESCs_Mouse0.83040325
106OCT4_21477851_ChIP-Seq_ESCs_Mouse0.82654843
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82323289
108AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82302931
109GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.81828742
110SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81774341
111PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81591812
112PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.81068515
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.80774576
114GF1_26923725_Chip-Seq_HPCs_Mouse0.80758983
115ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80491362
116EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80400368
117RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80400368
118IGF1R_20145208_ChIP-Seq_DFB_Human0.79345944
119SPI1_23127762_ChIP-Seq_K562_Human0.79151964
120TP53_23651856_ChIP-Seq_MEFs_Mouse0.78603571
121CTCF_21964334_Chip-Seq_Bcells_Human0.78568011
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.77872691
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.77155492
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.76851201
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.76251572
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.75845591
127SMAD4_21799915_ChIP-Seq_A2780_Human0.75837264
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.75478741
129HTT_18923047_ChIP-ChIP_STHdh_Human0.75259913
130CTCF_21964334_ChIP-Seq_BJAB-B_Human0.74620826
131SOX2_21211035_ChIP-Seq_LN229_Gbm0.74251859
132GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74206285
133SMC1_22415368_ChIP-Seq_MEFs_Mouse0.74016854
134WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73732763
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.73491382
136SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73234961
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.72930262
138BCAT_22108803_ChIP-Seq_LS180_Human0.71971530
139CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71925821
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71847717
141SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.71759746
142SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.70197729

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.98130456
2MP0003646_muscle_fatigue5.93358666
3MP0004084_abnormal_cardiac_muscle5.48107119
4MP0000751_myopathy5.43956836
5MP0004215_abnormal_myocardial_fiber4.69486016
6MP0004036_abnormal_muscle_relaxation4.16455924
7MP0000749_muscle_degeneration4.12654309
8MP0005330_cardiomyopathy3.85747160
9MP0004087_abnormal_muscle_fiber3.20631919
10MP0002972_abnormal_cardiac_muscle3.05505691
11MP0000750_abnormal_muscle_regeneration2.89502249
12MP0003137_abnormal_impulse_conducting2.81578720
13MP0008775_abnormal_heart_ventricle2.81343104
14MP0005620_abnormal_muscle_contractility2.72243239
15MP0002106_abnormal_muscle_physiology2.69946385
16MP0004130_abnormal_muscle_cell2.59710225
17MP0004145_abnormal_muscle_electrophysio2.58834543
18MP0010630_abnormal_cardiac_muscle2.57857990
19MP0001544_abnormal_cardiovascular_syste2.56344973
20MP0005385_cardiovascular_system_phenoty2.56344973
21MP0004484_altered_response_of2.53234191
22MP0002269_muscular_atrophy2.42744706
23MP0006138_congestive_heart_failure2.32541672
24MP0000747_muscle_weakness2.22487300
25MP0005369_muscle_phenotype2.19982644
26MP0000759_abnormal_skeletal_muscle2.14486087
27MP0003828_pulmonary_edema2.13466308
28MP0004085_abnormal_heartbeat2.00891398
29MP0003221_abnormal_cardiomyocyte_apopto1.99080349
30MP0004510_myositis1.97133319
31MP0004233_abnormal_muscle_weight1.77354684
32MP0006036_abnormal_mitochondrial_physio1.71285475
33MP0002127_abnormal_cardiovascular_syste1.61008422
34MP0003950_abnormal_plasma_membrane1.56641118
35MP0005666_abnormal_adipose_tissue1.49436726
36MP0002332_abnormal_exercise_endurance1.44554104
37MP0005670_abnormal_white_adipose1.36360966
38MP0003567_abnormal_fetal_cardiomyocyte1.20729279
39MP0000343_altered_response_to1.19045687
40MP0001661_extended_life_span1.18284258
41MP0000266_abnormal_heart_morphology1.10785916
42MP0004270_analgesia1.09417092
43MP0002234_abnormal_pharynx_morphology1.08981277
44MP0004185_abnormal_adipocyte_glucose1.07729866
45MP0005165_increased_susceptibility_to1.06976089
46MP0010368_abnormal_lymphatic_system1.04838208
47MP0005375_adipose_tissue_phenotype1.02048567
48MP0003279_aneurysm0.98057030
49MP0002108_abnormal_muscle_morphology0.97840741
50MP0006035_abnormal_mitochondrial_morpho0.95478906
51MP0005266_abnormal_metabolism0.83414803
52MP0000733_abnormal_muscle_development0.78746305
53MP0002128_abnormal_blood_circulation0.77855580
54MP0000230_abnormal_systemic_arterial0.75355242
55MP0003566_abnormal_cell_adhesion0.72821345
56MP0005623_abnormal_meninges_morphology0.72693496
57MP0003705_abnormal_hypodermis_morpholog0.71470258
58MP0002909_abnormal_adrenal_gland0.65890343
59MP0003806_abnormal_nucleotide_metabolis0.63402949
60MP0004043_abnormal_pH_regulation0.62715789
61MP0002971_abnormal_brown_adipose0.62544305
62MP0000013_abnormal_adipose_tissue0.59553627
63MP0000767_abnormal_smooth_muscle0.59221321
64MP0001879_abnormal_lymphatic_vessel0.58615773
65MP0000003_abnormal_adipose_tissue0.58539442
66MP0000372_irregular_coat_pigmentation0.50915180
67MP0005187_abnormal_penis_morphology0.50676702
68MP0001299_abnormal_eye_distance/0.48874883
69MP0005319_abnormal_enzyme/_coenzyme0.48415956
70MP0005451_abnormal_body_composition0.48351772
71MP0008438_abnormal_cutaneous_collagen0.47839586
72MP0005275_abnormal_skin_tensile0.47456425
73MP0008569_lethality_at_weaning0.47286348
74MP0004147_increased_porphyrin_level0.47253273
75MP0002078_abnormal_glucose_homeostasis0.46902792
76MP0002638_abnormal_pupillary_reflex0.45507663
77MP0008961_abnormal_basal_metabolism0.42767304
78MP0002925_abnormal_cardiovascular_devel0.42389184
79MP0003656_abnormal_erythrocyte_physiolo0.41370639
80MP0005167_abnormal_blood-brain_barrier0.38989372
81MP0004272_abnormal_basement_membrane0.38381416
82MP0003879_abnormal_hair_cell0.37713901
83MP0003045_fibrosis0.34797657
84MP0004134_abnormal_chest_morphology0.34172016
85MP0003984_embryonic_growth_retardation0.33660817
86MP0001614_abnormal_blood_vessel0.33514254
87MP0001784_abnormal_fluid_regulation0.33120318
88MP0005535_abnormal_body_temperature0.32791370
89MP0002088_abnormal_embryonic_growth/wei0.32343593
90MP0005376_homeostasis/metabolism_phenot0.32083020
91MP0005334_abnormal_fat_pad0.30851556
92MP0003948_abnormal_gas_homeostasis0.30133534
93MP0004142_abnormal_muscle_tone0.28609603
94MP0009384_cardiac_valve_regurgitation0.28215052
95MP0009780_abnormal_chondrocyte_physiolo0.26230302
96MP0009672_abnormal_birth_weight0.25959232
97MP0002118_abnormal_lipid_homeostasis0.25162262
98MP0000762_abnormal_tongue_morphology0.25123946
99MP0009840_abnormal_foam_cell0.24727251
100MP0009115_abnormal_fat_cell0.24711382
101MP0005166_decreased_susceptibility_to0.23777053
102MP0004924_abnormal_behavior0.23673602
103MP0005386_behavior/neurological_phenoty0.23673602
104MP0005595_abnormal_vascular_smooth0.22876442
105MP0005423_abnormal_somatic_nervous0.22800588
106MP0005083_abnormal_biliary_tract0.22555271
107MP0002877_abnormal_melanocyte_morpholog0.21767101
108MP0001853_heart_inflammation0.21719350
109MP0002114_abnormal_axial_skeleton0.21675220
110MP0001727_abnormal_embryo_implantation0.20943219
111MP0002896_abnormal_bone_mineralization0.20758554
112MP0003195_calcinosis0.20700252
113MP0005332_abnormal_amino_acid0.20535499
114MP0001958_emphysema0.19979682
115MP0005584_abnormal_enzyme/coenzyme_acti0.19948062
116MP0000249_abnormal_blood_vessel0.19855538
117MP0002822_catalepsy0.19353677
118MP0000579_abnormal_nail_morphology0.19098354
119MP0009250_abnormal_appendicular_skeleto0.18169432
120MP0001984_abnormal_olfaction0.18107424
121MP0005452_abnormal_adipose_tissue0.16680481
122MP0002066_abnormal_motor_capabilities/c0.16574872
123MP0003941_abnormal_skin_development0.16247796
124MP0001943_abnormal_respiration0.16224663
125MP0006276_abnormal_autonomic_nervous0.14641809

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.89891733
2Ventricular tachycardia (HP:0004756)6.77879967
3Calf muscle hypertrophy (HP:0008981)6.66726545
4Muscle hypertrophy of the lower extremities (HP:0008968)6.19184398
5Muscle fiber splitting (HP:0003555)6.14460476
6Exercise-induced myalgia (HP:0003738)6.02157216
7Exercise-induced muscle cramps (HP:0003710)5.90183227
8Atrial fibrillation (HP:0005110)5.85304614
9Abnormality of the calf musculature (HP:0001430)5.48510822
10Primary atrial arrhythmia (HP:0001692)5.47452483
11Hyporeflexia of lower limbs (HP:0002600)5.36314428
12Supraventricular tachycardia (HP:0004755)5.29234827
13Lipoatrophy (HP:0100578)5.20693528
14Supraventricular arrhythmia (HP:0005115)5.18122636
15Right ventricular cardiomyopathy (HP:0011663)5.06322942
16Myopathic facies (HP:0002058)4.94258868
17Myoglobinuria (HP:0002913)4.83389141
18Abnormality of the left ventricular outflow tract (HP:0011103)4.81443193
19Subaortic stenosis (HP:0001682)4.81443193
20EMG: myopathic abnormalities (HP:0003458)4.56430990
21Syncope (HP:0001279)4.55586387
22Bundle branch block (HP:0011710)4.50337444
23Dilated cardiomyopathy (HP:0001644)4.40315461
24Increased connective tissue (HP:0009025)4.29172643
25Palpitations (HP:0001962)4.16337115
26Prolonged QT interval (HP:0001657)4.01469546
27Difficulty running (HP:0009046)3.98523591
28Asymmetric septal hypertrophy (HP:0001670)3.96510282
29Ulnar deviation of the wrist (HP:0003049)3.89840275
30Muscle fiber inclusion bodies (HP:0100299)3.87284963
31Ventricular arrhythmia (HP:0004308)3.81685615
32Heart block (HP:0012722)3.74781105
33Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.74626800
34Rhabdomyolysis (HP:0003201)3.70839236
35Atrioventricular block (HP:0001678)3.58647282
36Myotonia (HP:0002486)3.54734032
37Type 1 muscle fiber predominance (HP:0003803)3.54658967
38Abnormal atrioventricular conduction (HP:0005150)3.54586661
39Calcaneovalgus deformity (HP:0001848)3.36340908
40Frequent falls (HP:0002359)3.36279069
41Ventricular fibrillation (HP:0001663)3.33247105
42Difficulty climbing stairs (HP:0003551)3.24707176
43Absent phalangeal crease (HP:0006109)3.11180798
44Nemaline bodies (HP:0003798)3.08558418
45Deformed tarsal bones (HP:0008119)2.96577752
46Abnormal EKG (HP:0003115)2.87338679
47Increased variability in muscle fiber diameter (HP:0003557)2.84937896
48Distal lower limb muscle weakness (HP:0009053)2.84081510
49Left ventricular hypertrophy (HP:0001712)2.81273871
50Abnormality of skeletal muscle fiber size (HP:0012084)2.76654293
51Hepatic necrosis (HP:0002605)2.75647483
52Neck muscle weakness (HP:0000467)2.74172371
53Areflexia of lower limbs (HP:0002522)2.72632813
54Malignant hyperthermia (HP:0002047)2.68328418
55Abnormal mitochondria in muscle tissue (HP:0008316)2.66599517
56Ketoacidosis (HP:0001993)2.63319556
57Muscle stiffness (HP:0003552)2.62028253
58Acute necrotizing encephalopathy (HP:0006965)2.61309304
59Palmoplantar keratoderma (HP:0000982)2.60210176
60Bulbar palsy (HP:0001283)2.59124533
61Limb-girdle muscle atrophy (HP:0003797)2.58882434
62Abnormal finger flexion creases (HP:0006143)2.56837163
63Testicular atrophy (HP:0000029)2.55605684
64Hypoglycemic coma (HP:0001325)2.48882598
65Rimmed vacuoles (HP:0003805)2.37902507
66Hepatocellular necrosis (HP:0001404)2.37818337
67Increased muscle lipid content (HP:0009058)2.32810218
68Distal lower limb amyotrophy (HP:0008944)2.31955467
69Abnormality of fatty-acid metabolism (HP:0004359)2.26181101
70Acute encephalopathy (HP:0006846)2.26069340
71Fetal akinesia sequence (HP:0001989)2.24708457
72Mildly elevated creatine phosphokinase (HP:0008180)2.23568814
73Weak cry (HP:0001612)2.22635940
74Dicarboxylic aciduria (HP:0003215)2.21053190
75Abnormality of dicarboxylic acid metabolism (HP:0010995)2.21053190
76Gowers sign (HP:0003391)2.18082075
77Facial diplegia (HP:0001349)2.18054717
78Slender build (HP:0001533)2.17174944
79Progressive macrocephaly (HP:0004481)2.15999122
80Hypoplastic ischia (HP:0003175)2.15628915
81Mitochondrial inheritance (HP:0001427)2.15544024
82Abnormality of the foot musculature (HP:0001436)2.14209184
83Muscular dystrophy (HP:0003560)2.13840980
84Conjunctival hamartoma (HP:0100780)2.13704283
85Cerebral edema (HP:0002181)2.12681874
86EMG: neuropathic changes (HP:0003445)2.12604845
87Hyperkalemia (HP:0002153)2.11569026
88Ragged-red muscle fibers (HP:0003200)2.09958238
89Spinal rigidity (HP:0003306)2.07580543
90Fatigable weakness (HP:0003473)2.07048738
91Abnormality of the neuromuscular junction (HP:0003398)2.07048738
92Hip contracture (HP:0003273)2.05912734
93Generalized muscle weakness (HP:0003324)2.05800735
94Foot dorsiflexor weakness (HP:0009027)2.05735120
95Increased CSF lactate (HP:0002490)2.05147217
96Abnormality of the shoulder girdle musculature (HP:0001435)2.03407382
97Sudden cardiac death (HP:0001645)2.02552245
98Increased intramyocellular lipid droplets (HP:0012240)2.01610476
99Waddling gait (HP:0002515)2.00428961
100Scapular winging (HP:0003691)1.98202977
101Exercise intolerance (HP:0003546)1.97735433
102Dysmetric saccades (HP:0000641)1.94369491
103Ketosis (HP:0001946)1.93886819
104Congestive heart failure (HP:0001635)1.92763741
105Progressive muscle weakness (HP:0003323)1.91869395
106Lactic acidosis (HP:0003128)1.90332376
107Proximal amyotrophy (HP:0007126)1.89823754
108Abnormality of alanine metabolism (HP:0010916)1.89117309
109Hyperalaninemia (HP:0003348)1.89117309
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89117309
111Respiratory failure (HP:0002878)1.87643064
112Abnormality of the ischium (HP:0003174)1.87288754
113Respiratory insufficiency due to muscle weakness (HP:0002747)1.85372343
114Abnormality of the calcaneus (HP:0008364)1.84956065
115Large for gestational age (HP:0001520)1.84705726
116Distal arthrogryposis (HP:0005684)1.84354382
117Pheochromocytoma (HP:0002666)1.84195346
118Centrally nucleated skeletal muscle fibers (HP:0003687)1.79976106
119Lower limb amyotrophy (HP:0007210)1.79871384
120Round ear (HP:0100830)1.79172698
121Hyperinsulinemic hypoglycemia (HP:0000825)1.79024919
122Steppage gait (HP:0003376)1.71077061
123Limb-girdle muscle weakness (HP:0003325)1.63862669
124Abnormality of the hip-girdle musculature (HP:0001445)1.61017150
125Abnormality of the musculature of the pelvis (HP:0001469)1.61017150
126Oligomenorrhea (HP:0000876)1.53281128
127Pelvic girdle muscle weakness (HP:0003749)1.51040643
128Shoulder girdle muscle weakness (HP:0003547)1.50712652
129Long clavicles (HP:0000890)1.47916662
130Nonprogressive disorder (HP:0003680)1.43351746

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN6.37223617
2OBSCN5.61867708
3PHKG14.08599202
4PHKG24.08599202
5LMTK23.67297996
6PDK33.34424368
7PDK43.34424368
8MYLK3.27497883
9DMPK3.13211205
10PKN22.73005061
11MUSK2.68175612
12TRIB32.56235490
13BCKDK2.35722072
14PIK3CA2.22593854
15NEK12.16022017
16PINK12.03784279
17PDK22.02791212
18TIE11.85022455
19STK241.62671701
20GRK71.48762278
21PAK31.31478307
22MARK11.30708893
23PRKD11.27773069
24CAMK2D1.26822166
25MAP3K71.15186244
26LIMK11.11963231
27ZAK1.10973489
28ILK1.10057813
29MAPK121.06188448
30MAP2K30.98542649
31INSRR0.97163932
32ROCK10.96148023
33MAPKAPK30.91410416
34WNK40.89761351
35STK40.88973174
36RIPK10.88222364
37PKN10.86962766
38MAP3K50.86905090
39PRKAA10.84977601
40CDC42BPA0.84412137
41EEF2K0.84279000
42PRKAA20.82082328
43PIK3CG0.81868083
44TRPM70.80394311
45CCNB10.75027097
46FLT30.74481005
47STK38L0.74262127
48PDGFRA0.73081884
49MAP3K30.71601932
50MOS0.69419839
51CAMK40.69273922
52EPHB10.69021220
53NME10.67191381
54DAPK30.65644982
55ERBB30.62019375
56ROCK20.60175901
57STK380.60131992
58MAPK40.58008301
59WNK10.56738285
60CAMK2A0.56266598
61TGFBR20.55371930
62RPS6KC10.51873787
63RPS6KL10.51873787
64DYRK1B0.51825326
65KDR0.51121154
66CAMK2B0.49935524
67PRKACB0.48568344
68MAP2K10.47366173
69AKT20.45418660
70RPS6KA60.43861799
71CAMK10.43520231
72MAP3K60.42623347
73ICK0.41291346
74NEK90.39703665
75PTK2B0.39130945
76SIK10.39004744
77KSR20.38877962
78PRKACA0.38552969
79PRKCE0.38488599
80PRKACG0.36968570
81CAMK2G0.36318768
82SGK20.35866962
83PDPK10.35595720
84MAP3K130.33464875
85PTK60.29870486
86PRKCH0.28852372
87PDK10.27187940
88STK390.26740941
89RPS6KA10.25187905
90LATS10.22564550
91MTOR0.22419566
92JAK10.22381320
93MAPK100.22331100
94PRKG10.21801099
95PRPF4B0.20910076
96FGFR40.20762093
97MARK20.20737311
98TBK10.20682636
99FER0.20555192
100LATS20.20519056
101SGK30.20457434
102BLK0.20140869
103MAP2K40.20088424
104EPHB20.19867745
105TAOK10.19348301
106PRKD30.18967813
107NME20.18602459
108RET0.18521421
109STK110.18386576
110ZAP700.18273552
111SGK10.18109229
112RPS6KA30.16452611
113MAPK110.16075363
114SGK4940.15685539
115SGK2230.15685539
116RPS6KB10.15613320
117MARK30.15358593
118MAP2K60.14947443
119MAPK70.14904177
120RPS6KB20.14492027
121EPHA30.14480750
122PDGFRB0.13073914
123PRKG20.12398317
124MAP3K10.12141262
125NLK0.11971503
126MAP3K100.11121550
127RPS6KA20.10953781
128TAOK20.10129645
129LRRK20.09975117
130FGFR30.08400791
131MAPK90.05373893

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.79631586
2Cardiac muscle contraction_Homo sapiens_hsa042604.29779462
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.23247626
4Dilated cardiomyopathy_Homo sapiens_hsa054143.90352219
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.83435053
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.43440492
7Propanoate metabolism_Homo sapiens_hsa006403.27681397
8Parkinsons disease_Homo sapiens_hsa050123.02211723
9Oxidative phosphorylation_Homo sapiens_hsa001902.92248691
10Fatty acid degradation_Homo sapiens_hsa000712.86979146
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65603064
12Carbon metabolism_Homo sapiens_hsa012002.43212137
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.30752702
14Alzheimers disease_Homo sapiens_hsa050102.26477840
15Fatty acid metabolism_Homo sapiens_hsa012122.16251179
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.08743333
17Viral myocarditis_Homo sapiens_hsa054161.86533574
18Huntingtons disease_Homo sapiens_hsa050161.84241685
19Pyruvate metabolism_Homo sapiens_hsa006201.76312318
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76087186
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44091534
22Butanoate metabolism_Homo sapiens_hsa006501.40134364
23Pentose phosphate pathway_Homo sapiens_hsa000301.37001902
24Fatty acid elongation_Homo sapiens_hsa000621.23584011
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20695260
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17422239
27Insulin resistance_Homo sapiens_hsa049311.14088793
28Starch and sucrose metabolism_Homo sapiens_hsa005001.10900298
29PPAR signaling pathway_Homo sapiens_hsa033201.10841437
30Biosynthesis of amino acids_Homo sapiens_hsa012301.07156753
31Glucagon signaling pathway_Homo sapiens_hsa049221.04770820
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.03918052
33cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99018746
34Insulin signaling pathway_Homo sapiens_hsa049100.97494032
35Tryptophan metabolism_Homo sapiens_hsa003800.85038500
36Lysine degradation_Homo sapiens_hsa003100.83433199
37Arginine biosynthesis_Homo sapiens_hsa002200.79149246
38Calcium signaling pathway_Homo sapiens_hsa040200.78002969
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75410721
40beta-Alanine metabolism_Homo sapiens_hsa004100.74102011
41AMPK signaling pathway_Homo sapiens_hsa041520.73901197
42Focal adhesion_Homo sapiens_hsa045100.73371254
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70829706
44Oxytocin signaling pathway_Homo sapiens_hsa049210.69431464
45Type II diabetes mellitus_Homo sapiens_hsa049300.68631885
46HIF-1 signaling pathway_Homo sapiens_hsa040660.68257821
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67254485
48Arginine and proline metabolism_Homo sapiens_hsa003300.66529781
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62482503
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.62014872
51Long-term potentiation_Homo sapiens_hsa047200.57650777
52Tight junction_Homo sapiens_hsa045300.57519698
53Nitrogen metabolism_Homo sapiens_hsa009100.57199252
54Galactose metabolism_Homo sapiens_hsa000520.56750364
55Fatty acid biosynthesis_Homo sapiens_hsa000610.54281269
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52621364
57Phenylalanine metabolism_Homo sapiens_hsa003600.51388685
58Peroxisome_Homo sapiens_hsa041460.48341704
59Salivary secretion_Homo sapiens_hsa049700.48140317
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47651535
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.47302848
62Renin secretion_Homo sapiens_hsa049240.45801218
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44825882
64ECM-receptor interaction_Homo sapiens_hsa045120.44758393
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42528555
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42153573
67Fructose and mannose metabolism_Homo sapiens_hsa000510.41985911
68cAMP signaling pathway_Homo sapiens_hsa040240.41669862
69Gastric acid secretion_Homo sapiens_hsa049710.38982095
70Insulin secretion_Homo sapiens_hsa049110.38299737
71Adherens junction_Homo sapiens_hsa045200.37316754
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34177796
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34048266
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32920726
75Regulation of autophagy_Homo sapiens_hsa041400.32713357
76Circadian rhythm_Homo sapiens_hsa047100.32322213
77Amoebiasis_Homo sapiens_hsa051460.31449220
78Amphetamine addiction_Homo sapiens_hsa050310.27027002
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24890010
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22935950
81Circadian entrainment_Homo sapiens_hsa047130.22259906
82Renal cell carcinoma_Homo sapiens_hsa052110.21834438
83Metabolic pathways_Homo sapiens_hsa011000.20735903
84Fat digestion and absorption_Homo sapiens_hsa049750.20365403
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19987497
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19344299
87Melanogenesis_Homo sapiens_hsa049160.19231630
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.19112368
89Proteoglycans in cancer_Homo sapiens_hsa052050.18693946
90Dorso-ventral axis formation_Homo sapiens_hsa043200.18390599
91Tyrosine metabolism_Homo sapiens_hsa003500.17881845
92Platelet activation_Homo sapiens_hsa046110.16583261
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.16437655
94GnRH signaling pathway_Homo sapiens_hsa049120.16355528
95VEGF signaling pathway_Homo sapiens_hsa043700.16032891
96Long-term depression_Homo sapiens_hsa047300.15471251
97mTOR signaling pathway_Homo sapiens_hsa041500.14920822
98Olfactory transduction_Homo sapiens_hsa047400.13585719
99Ovarian steroidogenesis_Homo sapiens_hsa049130.11603533
100Pancreatic secretion_Homo sapiens_hsa049720.10878865
101Histidine metabolism_Homo sapiens_hsa003400.09992895
102Gap junction_Homo sapiens_hsa045400.09438072
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08743500
104Cholinergic synapse_Homo sapiens_hsa047250.08213976
105Bile secretion_Homo sapiens_hsa049760.07829870
106FoxO signaling pathway_Homo sapiens_hsa040680.07172112
107GABAergic synapse_Homo sapiens_hsa047270.06745972
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.06406309
109Toxoplasmosis_Homo sapiens_hsa051450.04669599
110AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.04382848
111Glycerolipid metabolism_Homo sapiens_hsa005610.04282832
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.04056358
113MAPK signaling pathway_Homo sapiens_hsa040100.03781387
114Notch signaling pathway_Homo sapiens_hsa043300.03626434
115Taste transduction_Homo sapiens_hsa047420.01214910
116ABC transporters_Homo sapiens_hsa02010-0.0182499
117Small cell lung cancer_Homo sapiens_hsa05222-0.0157754

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