LMNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.69024041
2protein localization to kinetochore (GO:0034501)5.18780334
3nuclear pore organization (GO:0006999)4.69388530
4nuclear pore complex assembly (GO:0051292)4.60907012
5sister chromatid segregation (GO:0000819)4.52905714
6mitotic sister chromatid segregation (GO:0000070)4.49304623
7pre-miRNA processing (GO:0031054)4.38672999
8protein localization to chromosome, centromeric region (GO:0071459)4.31767091
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.21308590
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.17271130
11DNA replication-dependent nucleosome organization (GO:0034723)4.11888393
12DNA replication-dependent nucleosome assembly (GO:0006335)4.11888393
13establishment of integrated proviral latency (GO:0075713)4.11512236
14mitotic nuclear envelope disassembly (GO:0007077)4.10395849
15folic acid-containing compound biosynthetic process (GO:0009396)3.97078479
16DNA duplex unwinding (GO:0032508)3.94533642
17DNA geometric change (GO:0032392)3.92321928
18regulation of histone H3-K9 methylation (GO:0051570)3.86750646
19mitotic chromosome condensation (GO:0007076)3.86343432
20nuclear envelope disassembly (GO:0051081)3.84660166
21membrane disassembly (GO:0030397)3.84660166
22negative regulation of RNA splicing (GO:0033119)3.83947894
23DNA strand elongation involved in DNA replication (GO:0006271)3.82687623
24negative regulation of histone methylation (GO:0031061)3.80247881
25DNA replication initiation (GO:0006270)3.78983469
26regulation of posttranscriptional gene silencing (GO:0060147)3.77783058
27regulation of gene silencing by miRNA (GO:0060964)3.77783058
28regulation of gene silencing by RNA (GO:0060966)3.77783058
29heterochromatin organization (GO:0070828)3.77313915
30mitotic sister chromatid cohesion (GO:0007064)3.73960152
31negative regulation of mRNA processing (GO:0050686)3.73111242
32regulation of translational fidelity (GO:0006450)3.68592884
33regulation of sister chromatid cohesion (GO:0007063)3.68471496
34dosage compensation (GO:0007549)3.63181416
35positive regulation of chromosome segregation (GO:0051984)3.62964108
36DNA strand elongation (GO:0022616)3.61808819
37regulation of nucleobase-containing compound transport (GO:0032239)3.57893643
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52329332
39chromatin assembly (GO:0031497)3.52148649
40protein complex localization (GO:0031503)3.51984786
41RNA stabilization (GO:0043489)3.49389314
42mRNA stabilization (GO:0048255)3.49389314
43V(D)J recombination (GO:0033151)3.42773966
44negative regulation of mRNA metabolic process (GO:1903312)3.42264721
45pore complex assembly (GO:0046931)3.40342841
46regulation of RNA export from nucleus (GO:0046831)3.38617484
47DNA topological change (GO:0006265)3.36385096
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.35903946
49IMP biosynthetic process (GO:0006188)3.32861753
50mitotic metaphase plate congression (GO:0007080)3.28966781
51DNA packaging (GO:0006323)3.26864183
52establishment of viral latency (GO:0019043)3.26597300
53DNA synthesis involved in DNA repair (GO:0000731)3.26278136
54telomere maintenance via semi-conservative replication (GO:0032201)3.23978836
55protein localization to chromosome (GO:0034502)3.21806902
56protein export from nucleus (GO:0006611)3.19968947
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.17485197
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.17485197
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.17485197
60peptidyl-arginine omega-N-methylation (GO:0035247)3.15001671
61DNA conformation change (GO:0071103)3.14911240
62formation of translation preinitiation complex (GO:0001731)3.13291903
63alternative mRNA splicing, via spliceosome (GO:0000380)3.11455654
64double-strand break repair via nonhomologous end joining (GO:0006303)3.10471026
65non-recombinational repair (GO:0000726)3.10471026
66cellular protein complex localization (GO:0034629)3.09968620
67regulation of spindle organization (GO:0090224)3.09699816
68nuclear envelope organization (GO:0006998)3.08820863
69chromatin assembly or disassembly (GO:0006333)3.07687404
70regulation of chromosome segregation (GO:0051983)3.05921704
71mitotic recombination (GO:0006312)3.05479668
72kinetochore organization (GO:0051383)3.04240132
73paraxial mesoderm development (GO:0048339)3.03407838
74regulation of RNA stability (GO:0043487)3.03062886
75mRNA splicing, via spliceosome (GO:0000398)3.00939718
76RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.00939718
773-UTR-mediated mRNA stabilization (GO:0070935)3.00397247
78regulation of translational termination (GO:0006449)3.00371951
79translesion synthesis (GO:0019985)2.99424694
80DNA ligation (GO:0006266)2.98905952
81RNA splicing, via transesterification reactions (GO:0000375)2.98215186
82histone H2A monoubiquitination (GO:0035518)2.97814735
83metaphase plate congression (GO:0051310)2.93981039
84DNA replication checkpoint (GO:0000076)2.93962006
85somatic hypermutation of immunoglobulin genes (GO:0016446)2.90136947
86somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90136947
87IMP metabolic process (GO:0046040)2.89908491
88ATP-dependent chromatin remodeling (GO:0043044)2.88630377
89regulation of telomere maintenance via telomerase (GO:0032210)2.86907506
90regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.86895236
91chromosome condensation (GO:0030261)2.86139224
92telomere maintenance via recombination (GO:0000722)2.86031015
93protein-DNA complex disassembly (GO:0032986)2.85477710
94nucleosome disassembly (GO:0006337)2.85477710
95regulation of mitotic spindle organization (GO:0060236)2.84866079
96mRNA transport (GO:0051028)2.84708147
97regulation of gene silencing (GO:0060968)2.82465776
98regulation of mammary gland epithelial cell proliferation (GO:0033599)2.82227225
99regulation of mRNA stability (GO:0043488)2.81831402
100regulation of helicase activity (GO:0051095)2.81213264
101positive regulation of SMAD protein import into nucleus (GO:0060391)2.81133211
102nucleobase biosynthetic process (GO:0046112)2.79381367
103regulation of centriole replication (GO:0046599)2.78489071
104termination of RNA polymerase II transcription (GO:0006369)2.78174117
105peptidyl-arginine N-methylation (GO:0035246)2.78084797
106peptidyl-arginine methylation (GO:0018216)2.78084797
107viral transcription (GO:0019083)2.77419054
108glucocorticoid receptor signaling pathway (GO:0042921)2.77309605
109negative regulation of chromosome segregation (GO:0051985)2.76873795
110regulation of centrosome cycle (GO:0046605)2.76543672
111regulation of NFAT protein import into nucleus (GO:0051532)2.76306529
112chromosome segregation (GO:0007059)2.76186458
113negative regulation of DNA repair (GO:0045738)2.76055287
114regulation of DNA damage checkpoint (GO:2000001)2.75867673
115establishment of chromosome localization (GO:0051303)2.75686160
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.74911833
117translational termination (GO:0006415)2.73232598
118histone arginine methylation (GO:0034969)2.71169411
119regulation of histone H3-K27 methylation (GO:0061085)2.70894035
120viral mRNA export from host cell nucleus (GO:0046784)2.70878061
121regulation of chromatin binding (GO:0035561)2.62572374

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.86149731
2* FOXM1_23109430_ChIP-Seq_U2OS_Human5.76894731
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.85117662
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.41584133
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.30469993
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.28878036
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09251537
8* MYC_22102868_ChIP-Seq_BL_Human2.92575783
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77172111
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.26764746
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14963366
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.11156956
13AR_21909140_ChIP-Seq_LNCAP_Human2.05028923
14* E2F1_21310950_ChIP-Seq_MCF-7_Human2.02989813
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.01659319
16XRN2_22483619_ChIP-Seq_HELA_Human1.97992550
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.97306730
18NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94121660
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.90951940
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.85540859
21MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.81150735
22* VDR_21846776_ChIP-Seq_THP-1_Human1.79147843
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75492141
24CIITA_25753668_ChIP-Seq_RAJI_Human1.71096112
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67496733
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65193178
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60562061
28* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58214718
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56070736
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56070736
31KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56070736
32SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46794509
33KDM5A_27292631_Chip-Seq_BREAST_Human1.42550621
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42402256
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.42375877
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.42260338
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39313168
38TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39064539
39TTF2_22483619_ChIP-Seq_HELA_Human1.37165979
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.37085110
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.36215589
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35126375
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33663819
44HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.32427162
45ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31809108
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31413730
47NANOG_21062744_ChIP-ChIP_HESCs_Human1.31330756
48* TCF7_22412390_ChIP-Seq_EML_Mouse1.30842982
49* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29588375
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29498356
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29232405
52KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29183567
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29071556
54CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29041514
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.27102282
56FOXP3_21729870_ChIP-Seq_TREG_Human1.23956669
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23522148
58* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22771044
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22586549
60ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22297625
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21518764
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20972160
63VDR_23849224_ChIP-Seq_CD4+_Human1.20748596
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19901043
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19098432
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18133526
67CLOCK_20551151_ChIP-Seq_293T_Human1.16081487
68KDM2B_26808549_Chip-Seq_DND41_Human1.15718808
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.15191523
70* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14636400
71UTX_26944678_Chip-Seq_JUKART_Human1.13329228
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12767825
73GABP_19822575_ChIP-Seq_HepG2_Human1.12704506
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10380236
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08446774
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07070506
77NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06781693
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06629522
79DCP1A_22483619_ChIP-Seq_HELA_Human1.06591256
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06458909
81* ELK3_25401928_ChIP-Seq_HUVEC_Human1.06221121
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06023805
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05986331
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05449419
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05408853
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04836274
87* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04826877
88MAF_26560356_Chip-Seq_TH1_Human1.02959223
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.02308197
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01957412
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01690520
92CHD1_26751641_Chip-Seq_LNCaP_Human1.00623572
93BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99739030
94TFEB_21752829_ChIP-Seq_HELA_Human0.99120104
95ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99044684
96NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.98256530
97* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97549780
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96883128
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96627373
100* VDR_24763502_ChIP-Seq_THP-1_Human0.96071965
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95941100
102* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95853014
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94325380
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94092061
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93120915
106* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93034200
107MYB_21317192_ChIP-Seq_ERMYB_Mouse0.92471334
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91991434
109PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91932378
110RACK7_27058665_Chip-Seq_MCF-7_Human0.91655776
111P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90727877
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90672053
113* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.90381436
114ZNF263_19887448_ChIP-Seq_K562_Human0.90225855
115ELK1_19687146_ChIP-ChIP_HELA_Human0.89861973
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89750230
117NCOR1_26117541_ChIP-Seq_K562_Human0.89177444
118HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89171169
119KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88524127
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.88416129
121MAF_26560356_Chip-Seq_TH2_Human0.88071826
122* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88015483
123GATA1_22383799_ChIP-Seq_G1ME_Mouse0.87559352
124CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86692360
125MYB_26560356_Chip-Seq_TH1_Human0.86473333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.77752617
2* MP0003111_abnormal_nucleus_morphology3.59480780
3MP0003693_abnormal_embryo_hatching3.54867918
4MP0004957_abnormal_blastocyst_morpholog3.48959396
5MP0008057_abnormal_DNA_replication3.34624761
6MP0003077_abnormal_cell_cycle3.28693134
7MP0010352_gastrointestinal_tract_polyps2.93955959
8MP0003123_paternal_imprinting2.63101120
9MP0002009_preneoplasia2.56030324
10MP0003705_abnormal_hypodermis_morpholog2.48732712
11MP0001730_embryonic_growth_arrest2.48383953
12* MP0000350_abnormal_cell_proliferation2.26243127
13MP0000537_abnormal_urethra_morphology2.11355385
14MP0004197_abnormal_fetal_growth/weight/2.11237181
15MP0010307_abnormal_tumor_latency2.08013142
16MP0008007_abnormal_cellular_replicative2.07163464
17MP0001672_abnormal_embryogenesis/_devel2.05241054
18MP0005380_embryogenesis_phenotype2.05241054
19MP0009278_abnormal_bone_marrow2.04091344
20MP0002084_abnormal_developmental_patter2.03777425
21MP0010030_abnormal_orbit_morphology2.03579665
22* MP0005076_abnormal_cell_differentiation2.03576067
23MP0008932_abnormal_embryonic_tissue1.99840416
24MP0003121_genomic_imprinting1.97780316
25MP0002085_abnormal_embryonic_tissue1.97326024
26* MP0001697_abnormal_embryo_size1.88217821
27MP0003984_embryonic_growth_retardation1.87102577
28MP0002088_abnormal_embryonic_growth/wei1.85104941
29MP0002086_abnormal_extraembryonic_tissu1.84951671
30MP0008058_abnormal_DNA_repair1.83639350
31MP0005451_abnormal_body_composition1.81913521
32MP0002396_abnormal_hematopoietic_system1.80391889
33MP0009053_abnormal_anal_canal1.76336096
34MP0003567_abnormal_fetal_cardiomyocyte1.70965851
35MP0002080_prenatal_lethality1.70168283
36MP0003890_abnormal_embryonic-extraembry1.63013711
37MP0000490_abnormal_crypts_of1.57669880
38MP0004808_abnormal_hematopoietic_stem1.55512359
39MP0003119_abnormal_digestive_system1.49869359
40MP0001849_ear_inflammation1.48218022
41MP0002653_abnormal_ependyma_morphology1.41943766
42MP0001293_anophthalmia1.39549575
43MP0010234_abnormal_vibrissa_follicle1.39207522
44MP0001346_abnormal_lacrimal_gland1.36088363
45MP0003221_abnormal_cardiomyocyte_apopto1.33166552
46MP0002166_altered_tumor_susceptibility1.32149192
47MP0000428_abnormal_craniofacial_morphol1.28184717
48MP0003566_abnormal_cell_adhesion1.26217117
49MP0000313_abnormal_cell_death1.25272558
50MP0002019_abnormal_tumor_incidence1.24690453
51MP0000703_abnormal_thymus_morphology1.22531353
52MP0000733_abnormal_muscle_development1.22095826
53MP0006054_spinal_hemorrhage1.14582831
54MP0008877_abnormal_DNA_methylation1.14325069
55MP0009672_abnormal_birth_weight1.14307142
56MP0009703_decreased_birth_body1.12735343
57MP0003937_abnormal_limbs/digits/tail_de1.12636611
58MP0002006_tumorigenesis1.11131519
59MP0002092_abnormal_eye_morphology1.10950684
60MP0001915_intracranial_hemorrhage1.10590747
61MP0009697_abnormal_copulation1.09545299
62MP0002111_abnormal_tail_morphology1.09420778
63MP0001545_abnormal_hematopoietic_system1.06894329
64MP0005397_hematopoietic_system_phenotyp1.06894329
65MP0002697_abnormal_eye_size1.06764710
66MP0003115_abnormal_respiratory_system1.04425114
67MP0003935_abnormal_craniofacial_develop1.02743798
68MP0002925_abnormal_cardiovascular_devel1.02280026
69MP0000858_altered_metastatic_potential0.97237518
70MP0003861_abnormal_nervous_system0.95440603
71MP0004264_abnormal_extraembryonic_tissu0.95264199
72MP0003786_premature_aging0.94316156
73MP0005501_abnormal_skin_physiology0.93582970
74MP0002398_abnormal_bone_marrow0.93239371
75MP0000432_abnormal_head_morphology0.92902172
76MP0005023_abnormal_wound_healing0.91607017
77MP0004233_abnormal_muscle_weight0.90640254
78MP0002932_abnormal_joint_morphology0.90545144
79MP0001286_abnormal_eye_development0.90418984
80MP0001348_abnormal_lacrimal_gland0.89647694
81MP0003385_abnormal_body_wall0.89583276
82MP0008260_abnormal_autophagy0.89113972
83MP0003122_maternal_imprinting0.88269949
84MP0003453_abnormal_keratinocyte_physiol0.88093028
85MP0002722_abnormal_immune_system0.87798030
86MP0004858_abnormal_nervous_system0.87276238
87MP0003941_abnormal_skin_development0.84292458
88MP0008770_decreased_survivor_rate0.84232532
89MP0003315_abnormal_perineum_morphology0.83060433
90MP0009333_abnormal_splenocyte_physiolog0.82694982
91MP0005666_abnormal_adipose_tissue0.82278738
92MP0000477_abnormal_intestine_morphology0.82206250
93MP0005623_abnormal_meninges_morphology0.81837786
94MP0002282_abnormal_trachea_morphology0.81303916
95MP0002796_impaired_skin_barrier0.80535959
96MP0003283_abnormal_digestive_organ0.80491257
97MP0002429_abnormal_blood_cell0.79618225
98MP0003091_abnormal_cell_migration0.78931880
99MP0003755_abnormal_palate_morphology0.77139302
100MP0003303_peritoneal_inflammation0.76528938
101MP0003300_gastrointestinal_ulcer0.75512214
102MP0002163_abnormal_gland_morphology0.74792932
103MP0003763_abnormal_thymus_physiology0.74288341
104MP0005187_abnormal_penis_morphology0.74001669
105MP0001661_extended_life_span0.73596971
106MP0000689_abnormal_spleen_morphology0.73340361
107MP0004133_heterotaxia0.72771409
108MP0004947_skin_inflammation0.71464777
109MP0002089_abnormal_postnatal_growth/wei0.71422219
110MP0001835_abnormal_antigen_presentation0.71251954
111MP0002249_abnormal_larynx_morphology0.71069642
112MP0000266_abnormal_heart_morphology0.70776752
113MP0010630_abnormal_cardiac_muscle0.70629745
114MP0003787_abnormal_imprinting0.70383712
115MP0002877_abnormal_melanocyte_morpholog0.70028763
116MP0000049_abnormal_middle_ear0.68858388
117* MP0002114_abnormal_axial_skeleton0.68248894
118MP0001784_abnormal_fluid_regulation0.67783089
119MP0002210_abnormal_sex_determination0.67611695
120MP0001145_abnormal_male_reproductive0.67047321
121MP0004185_abnormal_adipocyte_glucose0.66652197
122MP0003943_abnormal_hepatobiliary_system0.65882677
123* MP0005621_abnormal_cell_physiology0.65407574
124* MP0005384_cellular_phenotype0.65164068
125MP0000716_abnormal_immune_system0.63976207
126MP0000358_abnormal_cell_content/0.62984535

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.99651818
2Short 4th metacarpal (HP:0010044)3.39056905
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.39056905
4Selective tooth agenesis (HP:0001592)3.26757146
5Medulloblastoma (HP:0002885)3.22362987
6Increased nuchal translucency (HP:0010880)3.16075140
7Cortical dysplasia (HP:0002539)3.00661545
8Astrocytoma (HP:0009592)2.99796227
9Abnormality of the astrocytes (HP:0100707)2.99796227
10Proximal placement of thumb (HP:0009623)2.89376986
11Volvulus (HP:0002580)2.87573757
12Hyperacusis (HP:0010780)2.85477949
13Deviation of the thumb (HP:0009603)2.84461054
14Colon cancer (HP:0003003)2.78803402
15Asymmetry of the thorax (HP:0001555)2.77323231
16Renal duplication (HP:0000075)2.76428471
17Abnormality of the 4th metacarpal (HP:0010012)2.64488377
18Nephroblastoma (Wilms tumor) (HP:0002667)2.63588907
19Abnormal number of incisors (HP:0011064)2.62470254
20Basal cell carcinoma (HP:0002671)2.60147253
21Neoplasm of the oral cavity (HP:0100649)2.59037907
22Rhabdomyosarcoma (HP:0002859)2.58132391
23Abnormality of the labia minora (HP:0012880)2.55144680
24Deep philtrum (HP:0002002)2.54886660
25Insomnia (HP:0100785)2.52491556
26Neoplasm of striated muscle (HP:0009728)2.47112483
27Patellar aplasia (HP:0006443)2.46564483
28Embryonal renal neoplasm (HP:0011794)2.40788481
29Reticulocytopenia (HP:0001896)2.39278910
30Progressive external ophthalmoplegia (HP:0000590)2.37991789
31Glioma (HP:0009733)2.37606164
32Deep palmar crease (HP:0006191)2.34885731
33Aplasia/Hypoplasia of the patella (HP:0006498)2.33325663
34Rib fusion (HP:0000902)2.30713047
35Chromsome breakage (HP:0040012)2.29718297
36Uterine leiomyosarcoma (HP:0002891)2.28471693
37Leiomyosarcoma (HP:0100243)2.28471693
38Malignant gastrointestinal tract tumors (HP:0006749)2.27509300
39Gastrointestinal carcinoma (HP:0002672)2.27509300
40Missing ribs (HP:0000921)2.25710283
41Atresia of the external auditory canal (HP:0000413)2.22862659
42Progressive muscle weakness (HP:0003323)2.19980885
43Facial hemangioma (HP:0000329)2.19615080
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.19009291
45Termporal pattern (HP:0011008)2.17786455
46Insidious onset (HP:0003587)2.17786455
47Agnosia (HP:0010524)2.15369977
48Ulnar bowing (HP:0003031)2.12568059
49Supernumerary ribs (HP:0005815)2.11567470
50Ankyloglossia (HP:0010296)2.11518722
51Long palpebral fissure (HP:0000637)2.11151869
52Skull defect (HP:0001362)2.10976085
53Syringomyelia (HP:0003396)2.10390038
54Spinal cord lesions (HP:0100561)2.10390038
55Transitional cell carcinoma of the bladder (HP:0006740)2.10172545
56High pitched voice (HP:0001620)2.10094268
57Absent radius (HP:0003974)2.10085465
58Spastic diplegia (HP:0001264)2.09535709
59Dysmetric saccades (HP:0000641)2.08885386
60Abnormality of the distal phalanx of the thumb (HP:0009617)2.07376970
61Ectopic kidney (HP:0000086)2.05492429
62Heterotopia (HP:0002282)2.05474764
63Multiple enchondromatosis (HP:0005701)2.04634094
64Long eyelashes (HP:0000527)2.02958627
65Skin tags (HP:0010609)2.02852550
66Renovascular hypertension (HP:0100817)2.01724751
67Esophageal atresia (HP:0002032)2.01134249
68Metaphyseal cupping (HP:0003021)1.99885632
69Obsessive-compulsive behavior (HP:0000722)1.99809088
70Subacute progressive viral hepatitis (HP:0006572)1.99414196
71Overriding aorta (HP:0002623)1.98962339
72Absent forearm bone (HP:0003953)1.97357230
73Aplasia involving forearm bones (HP:0009822)1.97357230
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.96186556
75Cutis marmorata (HP:0000965)1.94834818
76Cafe-au-lait spot (HP:0000957)1.94764211
77Prominent nose (HP:0000448)1.94094559
78Supernumerary bones of the axial skeleton (HP:0009144)1.93682097
79Bladder neoplasm (HP:0009725)1.92788738
80Bladder carcinoma (HP:0002862)1.92788738
81Elfin facies (HP:0004428)1.92182025
82Broad thumb (HP:0011304)1.92152844
83Aplasia/hypoplasia of the humerus (HP:0006507)1.91802724
84Biliary tract neoplasm (HP:0100574)1.91024257
85Abnormality of chromosome stability (HP:0003220)1.89180365
86Increased density of long bones (HP:0006392)1.88591895
87Trigonocephaly (HP:0000243)1.88485626
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.88403067
89Disproportionate tall stature (HP:0001519)1.87891242
90High anterior hairline (HP:0009890)1.87879675
91Broad palm (HP:0001169)1.87147051
92Overlapping toe (HP:0001845)1.87129145
93Amaurosis fugax (HP:0100576)1.86961032
94Meckel diverticulum (HP:0002245)1.86823363
95Abnormality of the fingertips (HP:0001211)1.86786807
96Short humerus (HP:0005792)1.86695228
97Impulsivity (HP:0100710)1.86376842
98Preauricular skin tag (HP:0000384)1.85631265
99Abnormality of the ileum (HP:0001549)1.85469447
100Birth length less than 3rd percentile (HP:0003561)1.84892594
101Adenoma sebaceum (HP:0009720)1.84525426
102Angiofibromas (HP:0010615)1.84525426
103Broad distal phalanx of finger (HP:0009836)1.83366085
104Viral hepatitis (HP:0006562)1.83269736
105Abnormality of oral frenula (HP:0000190)1.82538215
106Abdominal situs inversus (HP:0003363)1.82004975
107Abnormality of abdominal situs (HP:0011620)1.82004975
108Urethral obstruction (HP:0000796)1.80847894
109Myelodysplasia (HP:0002863)1.80761006
110Absent thumb (HP:0009777)1.80307089
111Acute lymphatic leukemia (HP:0006721)1.80195695
112Neoplasm of the pancreas (HP:0002894)1.80086511
113Shallow orbits (HP:0000586)1.79486340
114Short phalanx of the thumb (HP:0009660)1.79264311
115Embryonal neoplasm (HP:0002898)1.78797445
116Abnormality of the diencephalon (HP:0010662)1.78272172
117Patellar dislocation (HP:0002999)1.77584689
118Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77579205
119Abnormality of the phalanges of the hallux (HP:0010057)1.75410076
120Cellulitis (HP:0100658)1.74899824
121Abnormality of the preputium (HP:0100587)1.74849520
122Microvesicular hepatic steatosis (HP:0001414)1.74778897
123Ovarian neoplasm (HP:0100615)1.74729212
124Recurrent viral infections (HP:0004429)1.74309215
125Flared metaphyses (HP:0003015)1.74262186
126Tracheoesophageal fistula (HP:0002575)1.74124752
127Breast hypoplasia (HP:0003187)1.73873483
128Pointed chin (HP:0000307)1.73816745
129Sandal gap (HP:0001852)1.73770467
130Fibrous tissue neoplasm (HP:0012316)1.73358904
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.72321185
132Abnormality of the carotid arteries (HP:0005344)1.72271219
133Arnold-Chiari malformation (HP:0002308)1.71904796
134Fibroma (HP:0010614)1.71595945
13511 pairs of ribs (HP:0000878)1.69662932
136Duplication of thumb phalanx (HP:0009942)1.69573234
137Intestinal polyp (HP:0005266)1.69533736
138Short 5th finger (HP:0009237)1.68535012
139Duodenal stenosis (HP:0100867)1.67684308
140Small intestinal stenosis (HP:0012848)1.67684308
141Abnormality of the calcaneus (HP:0008364)1.67248263
142Uterine neoplasm (HP:0010784)1.66585638
143Abnormal foot bone ossification (HP:0010675)1.66387303
144Squamous cell carcinoma (HP:0002860)1.65520126
145Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65197064
146Short 1st metacarpal (HP:0010034)1.65197064
147Bowel diverticulosis (HP:0005222)1.65057554
148Acute myeloid leukemia (HP:0004808)1.64220368
149Flat acetabular roof (HP:0003180)1.63404035
150Spina bifida occulta (HP:0003298)1.63293509
151Anal stenosis (HP:0002025)1.62869155
152Relative macrocephaly (HP:0004482)1.60242040
153Vertebral arch anomaly (HP:0008438)1.59542884
154Abnormality of cochlea (HP:0000375)1.59457540
155Pelvic girdle muscle weakness (HP:0003749)1.59383109
156Abnormality of the salivary glands (HP:0010286)1.59227313
157Renal cell carcinoma (HP:0005584)1.58821816
158Radioulnar synostosis (HP:0002974)1.57603474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.09844364
2EEF2K4.04593575
3SMG14.03124821
4CDK123.96800211
5MAP3K103.93344341
6NEK22.97360276
7PKN22.74185050
8BUB12.59512261
9WEE12.53897388
10TRIB32.24805613
11TTK2.15238662
12PRPF4B2.13991159
13STK101.96612538
14CDK41.87712270
15TSSK61.85701928
16NEK11.84509425
17PASK1.83461834
18TAF11.70014561
19MKNK11.69760464
20FGFR41.66289764
21ALK1.61023021
22CDK71.59689344
23TESK21.57789735
24BRD41.54008277
25ICK1.52897977
26MAP3K81.50245031
27ATR1.45713076
28PLK11.43004304
29CDK61.41497460
30SRPK11.39091914
31PAK41.36100225
32MKNK21.35800478
33SCYL21.34870659
34CHEK11.34605525
35IRAK31.33472692
36EPHA21.31373675
37AURKB1.29624789
38CHEK21.23310155
39GRK61.22075485
40PTK61.19815279
41LRRK21.16785844
42TGFBR11.16757150
43MTOR1.15569378
44STK41.15480947
45MAP3K141.13829917
46DYRK31.03940100
47STK31.02265466
48PDGFRA1.00014442
49KSR20.99962803
50NME20.99884512
51* CDK20.97043729
52MAP4K10.95845756
53PLK30.95669379
54VRK20.95567244
55ATM0.94953161
56LATS10.92746073
57PIM10.92607177
58MAP3K130.91355764
59RPS6KA40.90392347
60TTN0.88933324
61BMX0.88724935
62SIK10.86189650
63TLK10.84352509
64CAMK1G0.81585681
65PAK20.78302728
66AURKA0.77880284
67CLK10.77428084
68BRSK20.76557748
69FLT30.76317675
70MELK0.75972208
71LATS20.74807712
72TYRO30.74455011
73BRAF0.74211432
74ACVR1B0.72907363
75* RPS6KB20.72697601
76PBK0.70612871
77FGFR10.70242290
78EIF2AK10.69269916
79* CDK10.69196231
80CDK80.67111656
81IRAK40.66483929
82SIK20.63946834
83BRSK10.61103035
84YES10.60580494
85CSNK1D0.59516691
86RIPK10.59037202
87AKT20.58543664
88MAP2K30.57296109
89EIF2AK20.56431626
90TESK10.55417334
91PLK40.54731852
92ILK0.53309297
93PAK10.53165721
94TAOK20.52952732
95IRAK20.52519284
96CDK90.52188170
97FGFR30.51803071
98MAP3K90.51647149
99MAPKAPK30.51577486
100CSNK1E0.50021766
101RIPK40.49863928
102PRKDC0.49291665
103MAP2K20.46349612
104MAPK140.45758922
105CSNK2A20.45565597
106PNCK0.43528330
107RAF10.42428667
108DYRK1B0.41962972
109RPS6KA10.41212037
110CSF1R0.39399576
111MAPK110.38525357
112AKT10.38055268
113PRKCI0.37729449
114BTK0.37561144
115MAPK10.36672033
116KDR0.35386351
117PDGFRB0.34159824
118FGR0.33098440
119ERN10.32526419
120RPS6KC10.30381925
121RPS6KL10.30381925
122KSR10.29296262
123UHMK10.29173547
124CAMK1D0.29013660
125MAPKAPK20.28979026
126* GSK3B0.28821705
127DDR20.28748847
128CSNK2A10.28184949
129VRK10.26443190

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24972978
2Mismatch repair_Homo sapiens_hsa034303.71653011
3Spliceosome_Homo sapiens_hsa030403.34116960
4RNA transport_Homo sapiens_hsa030132.99793652
5Cell cycle_Homo sapiens_hsa041102.94992352
6One carbon pool by folate_Homo sapiens_hsa006702.69518694
7Base excision repair_Homo sapiens_hsa034102.67756839
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61565971
9mRNA surveillance pathway_Homo sapiens_hsa030152.41445420
10Nucleotide excision repair_Homo sapiens_hsa034202.20659941
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.09359135
12Homologous recombination_Homo sapiens_hsa034402.07435908
13Ribosome_Homo sapiens_hsa030101.85189436
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.79777449
15Fanconi anemia pathway_Homo sapiens_hsa034601.75568832
16Non-homologous end-joining_Homo sapiens_hsa034501.71103456
17p53 signaling pathway_Homo sapiens_hsa041151.58517322
18MicroRNAs in cancer_Homo sapiens_hsa052061.53905586
19RNA degradation_Homo sapiens_hsa030181.49147906
20Viral carcinogenesis_Homo sapiens_hsa052031.48967682
21Basal cell carcinoma_Homo sapiens_hsa052171.45891403
22Chronic myeloid leukemia_Homo sapiens_hsa052201.43731761
23Systemic lupus erythematosus_Homo sapiens_hsa053221.38650942
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.35277778
25Notch signaling pathway_Homo sapiens_hsa043301.33140761
26Colorectal cancer_Homo sapiens_hsa052101.31547750
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.30823300
28HTLV-I infection_Homo sapiens_hsa051661.29351586
29Hippo signaling pathway_Homo sapiens_hsa043901.28562388
30Small cell lung cancer_Homo sapiens_hsa052221.25224796
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.22583105
32Antigen processing and presentation_Homo sapiens_hsa046121.15518886
33Epstein-Barr virus infection_Homo sapiens_hsa051691.12508922
34RNA polymerase_Homo sapiens_hsa030201.12433061
35mTOR signaling pathway_Homo sapiens_hsa041501.11090383
36Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10660402
37Adherens junction_Homo sapiens_hsa045201.09293431
38Oocyte meiosis_Homo sapiens_hsa041141.08775591
39Pyrimidine metabolism_Homo sapiens_hsa002401.08307543
40Hedgehog signaling pathway_Homo sapiens_hsa043401.03711732
41Herpes simplex infection_Homo sapiens_hsa051681.03070285
42Thyroid cancer_Homo sapiens_hsa052161.01494624
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99411910
44Lysine degradation_Homo sapiens_hsa003100.98516086
45Bladder cancer_Homo sapiens_hsa052190.98483144
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.98155859
47Viral myocarditis_Homo sapiens_hsa054160.97933639
48Non-small cell lung cancer_Homo sapiens_hsa052230.97488282
49Primary immunodeficiency_Homo sapiens_hsa053400.94110464
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93801357
51Basal transcription factors_Homo sapiens_hsa030220.93606957
52Endometrial cancer_Homo sapiens_hsa052130.91201078
53Proteoglycans in cancer_Homo sapiens_hsa052050.87527849
54TGF-beta signaling pathway_Homo sapiens_hsa043500.83679383
55ErbB signaling pathway_Homo sapiens_hsa040120.82924118
56Acute myeloid leukemia_Homo sapiens_hsa052210.82890757
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81989271
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81019044
59Hepatitis B_Homo sapiens_hsa051610.77806405
60B cell receptor signaling pathway_Homo sapiens_hsa046620.77405134
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77120971
62Pancreatic cancer_Homo sapiens_hsa052120.76371662
63Pathways in cancer_Homo sapiens_hsa052000.75671657
64Biosynthesis of amino acids_Homo sapiens_hsa012300.75060482
65Prolactin signaling pathway_Homo sapiens_hsa049170.74687865
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74288805
67Prostate cancer_Homo sapiens_hsa052150.73598836
68Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71386797
69Hepatitis C_Homo sapiens_hsa051600.69615542
70Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69152704
71Carbon metabolism_Homo sapiens_hsa012000.68902986
72Wnt signaling pathway_Homo sapiens_hsa043100.68165809
73Selenocompound metabolism_Homo sapiens_hsa004500.67645012
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.66864272
75Alcoholism_Homo sapiens_hsa050340.66688738
76Insulin signaling pathway_Homo sapiens_hsa049100.65225992
77Shigellosis_Homo sapiens_hsa051310.64174424
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.62459400
79* Apoptosis_Homo sapiens_hsa042100.60944255
80Tight junction_Homo sapiens_hsa045300.60836331
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58949617
82Legionellosis_Homo sapiens_hsa051340.58376332
83HIF-1 signaling pathway_Homo sapiens_hsa040660.57395171
84VEGF signaling pathway_Homo sapiens_hsa043700.57115615
85Proteasome_Homo sapiens_hsa030500.56254428
86Glioma_Homo sapiens_hsa052140.54155341
87Renal cell carcinoma_Homo sapiens_hsa052110.54073870
88Focal adhesion_Homo sapiens_hsa045100.53580592
89T cell receptor signaling pathway_Homo sapiens_hsa046600.53066947
90Prion diseases_Homo sapiens_hsa050200.51894065
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.51786515
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51261520
93Pentose phosphate pathway_Homo sapiens_hsa000300.51232167
94FoxO signaling pathway_Homo sapiens_hsa040680.49568806
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48930178
96Measles_Homo sapiens_hsa051620.48800587
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.46629059
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46604963
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.46383145
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.46103254
101Inositol phosphate metabolism_Homo sapiens_hsa005620.45645375
102Fructose and mannose metabolism_Homo sapiens_hsa000510.43494928
103Choline metabolism in cancer_Homo sapiens_hsa052310.43383008
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42804762
105Melanoma_Homo sapiens_hsa052180.42799241
106Osteoclast differentiation_Homo sapiens_hsa043800.40292099
107AMPK signaling pathway_Homo sapiens_hsa041520.38081460
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37776825
109Toxoplasmosis_Homo sapiens_hsa051450.35589399
110Influenza A_Homo sapiens_hsa051640.33435918
111Estrogen signaling pathway_Homo sapiens_hsa049150.29541648
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.29294694
113Purine metabolism_Homo sapiens_hsa002300.29235311
114Platelet activation_Homo sapiens_hsa046110.28452271
115Dorso-ventral axis formation_Homo sapiens_hsa043200.28118806
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26563557
117Rap1 signaling pathway_Homo sapiens_hsa040150.26355339
118Leishmaniasis_Homo sapiens_hsa051400.25790454

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