LITAF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppressor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.96076471
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.56105612
3negative regulation of cell killing (GO:0031342)5.56105612
4positive regulation of gamma-delta T cell activation (GO:0046645)5.34142318
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.99316106
6negative regulation of interleukin-12 production (GO:0032695)4.81286767
7antigen processing and presentation of endogenous antigen (GO:0019883)4.71130272
8antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.57866820
9detection of bacterium (GO:0016045)4.23945756
10regulation of B cell receptor signaling pathway (GO:0050855)4.04276110
11positive regulation by symbiont of host defense response (GO:0052509)4.02439449
12modulation by symbiont of host defense response (GO:0052031)4.02439449
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.02439449
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.02439449
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.02439449
16modulation by symbiont of host immune response (GO:0052553)4.02439449
17type I interferon signaling pathway (GO:0060337)3.93039986
18cellular response to type I interferon (GO:0071357)3.93039986
19response to type I interferon (GO:0034340)3.89555387
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.87285790
21regulation of gamma-delta T cell activation (GO:0046643)3.86899954
22granulocyte activation (GO:0036230)3.81431609
23neutrophil activation (GO:0042119)3.79209707
24response to peptidoglycan (GO:0032494)3.76609461
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.68027041
26respiratory burst (GO:0045730)3.66538918
27negative regulation of lymphocyte mediated immunity (GO:0002707)3.64830334
28detection of biotic stimulus (GO:0009595)3.61005296
29interferon-gamma-mediated signaling pathway (GO:0060333)3.52664325
30germinal center formation (GO:0002467)3.50515766
31response to interleukin-15 (GO:0070672)3.49690574
32central nervous system myelination (GO:0022010)3.46642698
33axon ensheathment in central nervous system (GO:0032291)3.46642698
34defense response to protozoan (GO:0042832)3.46562413
35macrophage activation involved in immune response (GO:0002281)3.41955949
36positive regulation of interferon-alpha production (GO:0032727)3.40279833
37response to host (GO:0075136)3.37414275
38response to host defenses (GO:0052200)3.37414275
39response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37414275
40lipopolysaccharide-mediated signaling pathway (GO:0031663)3.37260608
41regulation of T cell tolerance induction (GO:0002664)3.35120743
42negative regulation of T cell mediated immunity (GO:0002710)3.33142064
43B cell mediated immunity (GO:0019724)3.31405202
44response to muramyl dipeptide (GO:0032495)3.30025856
45negative regulation of leukocyte mediated immunity (GO:0002704)3.28210624
46regulation of interferon-beta biosynthetic process (GO:0045357)3.28157820
47superoxide anion generation (GO:0042554)3.25838244
48positive regulation of monocyte chemotaxis (GO:0090026)3.24851894
49regulation of tolerance induction (GO:0002643)3.24584248
50regulation of interferon-alpha production (GO:0032647)3.23575657
51cellular response to interleukin-15 (GO:0071350)3.22773719
52regulation of gamma-delta T cell differentiation (GO:0045586)3.22350841
53response to protozoan (GO:0001562)3.21730514
54neutrophil mediated immunity (GO:0002446)3.20683065
55amyloid precursor protein catabolic process (GO:0042987)3.18541392
56regulation of T-helper 2 cell differentiation (GO:0045628)3.18467496
57immunoglobulin mediated immune response (GO:0016064)3.16476594
58eosinophil chemotaxis (GO:0048245)3.16362284
59regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.14226134
60negative regulation of cytokine production involved in immune response (GO:0002719)3.14132352
61positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.13041616
62positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.11549565
63hydrogen peroxide biosynthetic process (GO:0050665)3.11510967
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.10257807
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.09438326
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08077434
67NIK/NF-kappaB signaling (GO:0038061)3.06366688
68response to lipoprotein particle (GO:0055094)3.05745587
69production of molecular mediator involved in inflammatory response (GO:0002532)3.05604877
70negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.00774686
71positive regulation of chemokine biosynthetic process (GO:0045080)2.99923113
72negative regulation of lipid storage (GO:0010888)2.99129929
73positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.98249970
74dendritic cell chemotaxis (GO:0002407)2.98154110
75myeloid cell activation involved in immune response (GO:0002275)2.97404306
76positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97356312
77detection of molecule of bacterial origin (GO:0032490)2.92584295
78regulation of mononuclear cell migration (GO:0071675)2.91868950
79T cell migration (GO:0072678)2.91237605
80monocyte chemotaxis (GO:0002548)2.90455808
81positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.88219758
82regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87407291
83regulation of T cell mediated cytotoxicity (GO:0001914)2.87288257
84macrophage activation (GO:0042116)2.87284358
85membrane raft organization (GO:0031579)2.86129870
86antigen processing and presentation via MHC class Ib (GO:0002475)2.86129242
87negative regulation of innate immune response (GO:0045824)2.85422151
88positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84275650
89eosinophil migration (GO:0072677)2.84235649
90myeloid dendritic cell activation (GO:0001773)2.83529000
91regulation of alpha-beta T cell proliferation (GO:0046640)2.83324558
92regulation of myeloid leukocyte mediated immunity (GO:0002886)2.83116511
93dendritic cell migration (GO:0036336)2.81936031
94positive regulation of tolerance induction (GO:0002645)2.81820674
95cellular extravasation (GO:0045123)2.80437028
96regulation of regulatory T cell differentiation (GO:0045589)2.78658107
97tolerance induction (GO:0002507)2.77807629
98T-helper 1 type immune response (GO:0042088)2.77661238
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77289594
100regulation of natural killer cell mediated immunity (GO:0002715)2.77289594
101regulation of leukocyte degranulation (GO:0043300)2.77006562
102natural killer cell mediated cytotoxicity (GO:0042267)2.76149097
103natural killer cell mediated immunity (GO:0002228)2.76149097
104positive regulation of antigen processing and presentation (GO:0002579)2.76049550
105leukocyte migration involved in inflammatory response (GO:0002523)2.74199848
106positive regulation of cellular amide metabolic process (GO:0034250)2.73962444
107reactive oxygen species biosynthetic process (GO:1903409)2.73783704
108negative regulation of mast cell activation (GO:0033004)2.72352520
109microglial cell activation (GO:0001774)2.70075781
110regulation of lymphocyte migration (GO:2000401)2.69557299
111positive regulation of mast cell activation (GO:0033005)2.68803734
112amyloid precursor protein metabolic process (GO:0042982)2.68798787
113regulation of mast cell degranulation (GO:0043304)2.68797576
114regulation of lymphocyte chemotaxis (GO:1901623)2.68242917
115phagocytosis, engulfment (GO:0006911)2.65947854
116regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.63809239
117detection of other organism (GO:0098543)2.61965371
118response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61590722
119response to host immune response (GO:0052572)2.61590722
120regulation of monocyte chemotaxis (GO:0090025)2.61109129
121regulation of mast cell activation (GO:0033003)2.60615551
122positive regulation of macrophage cytokine production (GO:0060907)2.59312331
123positive regulation of type 2 immune response (GO:0002830)2.58517174
124positive regulation of lymphocyte migration (GO:2000403)2.57525039
125leukocyte aggregation (GO:0070486)2.57076106
126regulation of T cell migration (GO:2000404)2.56680541
127myeloid leukocyte activation (GO:0002274)2.55254348
128positive regulation of mast cell activation involved in immune response (GO:0033008)2.55093910
129positive regulation of mast cell degranulation (GO:0043306)2.55093910
130pinocytosis (GO:0006907)2.53313951
131wound healing, spreading of epidermal cells (GO:0035313)2.53024739
132regulation of mast cell activation involved in immune response (GO:0033006)2.52534130
133positive regulation of interleukin-6 production (GO:0032755)2.52423797
134positive regulation of leukocyte degranulation (GO:0043302)2.51831214
135low-density lipoprotein particle clearance (GO:0034383)2.51730787
136regulation of chemokine biosynthetic process (GO:0045073)2.50639320
137adhesion of symbiont to host cell (GO:0044650)2.49167175
138virion attachment to host cell (GO:0019062)2.49167175
139regulation of antigen processing and presentation (GO:0002577)2.49100328
140detection of external biotic stimulus (GO:0098581)2.49094190
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.48917703
142wound healing, spreading of cells (GO:0044319)2.48324997
143regulation of interleukin-8 biosynthetic process (GO:0045414)2.48171369
144regulation of T-helper 1 cell differentiation (GO:0045625)2.48079507
145regulation of fever generation (GO:0031620)2.47535989
146positive regulation of interferon-beta production (GO:0032728)2.47042630
147myelin maintenance (GO:0043217)2.46406749
148positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.45532986
149myeloid cell homeostasis (GO:0002262)2.44713281
150myeloid dendritic cell differentiation (GO:0043011)2.44154409
151regulation of heterotypic cell-cell adhesion (GO:0034114)2.44088682
152fatty acid elongation (GO:0030497)2.43348521
153regulation of cholesterol storage (GO:0010885)2.40535417
154positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.39672300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.14269947
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.48584805
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.80494150
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.55868588
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.62052824
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58430023
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.58210276
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50306700
9* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.40450811
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.16467087
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09571302
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.60231164
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.57489590
14STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.46717329
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.38968862
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.34693448
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28387556
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27334497
19VDR_21846776_ChIP-Seq_THP-1_Human2.22759556
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21737209
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02661605
22* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.01943203
23* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98672352
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.96634473
25STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87685715
26UTX_26944678_Chip-Seq_JUKART_Human1.79438873
27SMAD_19615063_ChIP-ChIP_OVARY_Human1.78260230
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77763541
29* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72612765
30MYC_22102868_ChIP-Seq_BL_Human1.69160035
31VDR_24787735_ChIP-Seq_THP-1_Human1.68910731
32KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67885605
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.63779444
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.63610563
35* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61881590
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60638332
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.60534192
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56958768
39NRF2_20460467_ChIP-Seq_MEFs_Mouse1.55360582
40NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.55360582
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.54363632
42SPI1_23547873_ChIP-Seq_NB4_Human1.53249229
43* SOX2_20726797_ChIP-Seq_SW620_Human1.52511001
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.52110314
45PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50013218
46* MAF_26560356_Chip-Seq_TH2_Human1.47681693
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46757214
48RUNX_20019798_ChIP-Seq_JUKART_Human1.45420048
49LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45227366
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44969233
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44302804
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40614105
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40614105
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40036662
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39392836
56CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39290793
57PU_27001747_Chip-Seq_BMDM_Mouse1.39276726
58KDM2B_26808549_Chip-Seq_DND41_Human1.38994902
59* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37764618
60CJUN_26792858_Chip-Seq_BT549_Human1.37731836
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.35044863
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34014736
63P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33690394
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.32965933
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.31377264
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31211471
67VDR_24763502_ChIP-Seq_THP-1_Human1.31159997
68ESR1_21235772_ChIP-Seq_MCF-7_Human1.31033519
69* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.30849759
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28977186
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28922441
72CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28916479
73CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28591665
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.27191613
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25023928
76* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23421071
77KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20861869
78GATA1_22025678_ChIP-Seq_K562_Human1.20445693
79MYB_26560356_Chip-Seq_TH2_Human1.19584410
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19071672
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.18274301
82PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17477167
83* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17394226
84JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16877692
85* LXR_22158963_ChIP-Seq_LIVER_Mouse1.16711098
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16640735
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.16023119
88ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15786441
89RXR_22158963_ChIP-Seq_LIVER_Mouse1.14153667
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13908118
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11274403
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10698443
93LXR_22292898_ChIP-Seq_THP-1_Human1.10666576
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07423399
95EGR1_19032775_ChIP-ChIP_M12_Human1.07153284
96SCL_19346495_ChIP-Seq_HPC-7_Human1.04244890
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.03672845
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03052747
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03052747
100KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03052747
101RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.01709534
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.00938133
103FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00309520
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00016426
105GATA1_19941826_ChIP-Seq_K562_Human0.98712236
106SPI1_23127762_ChIP-Seq_K562_Human0.97736763
107* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96954485
108FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96068405
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95670180
110SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95533243
111SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95490874
112MAF_26560356_Chip-Seq_TH1_Human0.94031882
113MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93953151
114* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.92763465
115ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91802616
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91537310
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90846997
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90326775
119KDM2B_26808549_Chip-Seq_JURKAT_Human0.90287251
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89184477
121GATA4_25053715_ChIP-Seq_YYC3_Human0.88805233
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.88373627
123GATA3_26560356_Chip-Seq_TH2_Human0.87994656
124* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84916685
125* CLOCK_20551151_ChIP-Seq_293T_Human0.84557303
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.84386373
127MYB_26560356_Chip-Seq_TH1_Human0.84068837
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83106663
129* RACK7_27058665_Chip-Seq_MCF-7_Human0.82456577
130GATA3_27048872_Chip-Seq_THYMUS_Human0.82359407
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82050195
132* BCL6_27268052_Chip-Seq_Bcells_Human0.80783578
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80723643
134NCOR1_26117541_ChIP-Seq_K562_Human0.79993377
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79679800
136GATA2_19941826_ChIP-Seq_K562_Human0.76691893
137* BCOR_27268052_Chip-Seq_Bcells_Human0.76627407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.35841979
2MP0003724_increased_susceptibility_to3.35274243
3MP0003436_decreased_susceptibility_to3.25214200
4MP0002148_abnormal_hypersensitivity_rea3.24432667
5MP0009785_altered_susceptibility_to3.06234384
6MP0006082_CNS_inflammation2.86279021
7MP0002419_abnormal_innate_immunity2.81340108
8MP0005058_abnormal_lysosome_morphology2.70882859
9MP0005000_abnormal_immune_tolerance2.61624426
10MP0003303_peritoneal_inflammation2.45369885
11MP0005025_abnormal_response_to2.38822720
12MP0009840_abnormal_foam_cell2.33694962
13MP0000920_abnormal_myelination2.14542099
14MP0001533_abnormal_skeleton_physiology2.10339636
15MP0005387_immune_system_phenotype2.06134475
16MP0001790_abnormal_immune_system2.06134475
17MP0003191_abnormal_cellular_cholesterol2.05668408
18MP0008438_abnormal_cutaneous_collagen2.04877860
19MP0002452_abnormal_antigen_presenting2.01789097
20MP0000343_altered_response_to1.92567330
21* MP0002723_abnormal_immune_serum1.88822282
22MP0005671_abnormal_response_to1.87879340
23MP0003690_abnormal_glial_cell1.84803746
24MP0003763_abnormal_thymus_physiology1.77679377
25MP0003950_abnormal_plasma_membrane1.75626820
26MP0003448_altered_tumor_morphology1.75212838
27MP0004947_skin_inflammation1.74676717
28MP0001800_abnormal_humoral_immune1.72685731
29MP0003186_abnormal_redox_activity1.71094003
30MP0001851_eye_inflammation1.70257423
31MP0002405_respiratory_system_inflammati1.70150079
32MP0000685_abnormal_immune_system1.69750210
33MP0009764_decreased_sensitivity_to1.67556963
34MP0001853_heart_inflammation1.67341414
35MP0002254_reproductive_system_inflammat1.65912959
36MP0001819_abnormal_immune_cell1.65406442
37MP0003453_abnormal_keratinocyte_physiol1.63541646
38MP0002420_abnormal_adaptive_immunity1.63030743
39MP0005464_abnormal_platelet_physiology1.60067538
40MP0006054_spinal_hemorrhage1.58924544
41MP0005164_abnormal_response_to1.56928329
42MP0005167_abnormal_blood-brain_barrier1.54054708
43MP0003075_altered_response_to1.53663115
44MP0000858_altered_metastatic_potential1.49801808
45* MP0001845_abnormal_inflammatory_respons1.46033243
46MP0010155_abnormal_intestine_physiology1.44544939
47MP0002998_abnormal_bone_remodeling1.40110808
48MP0009333_abnormal_splenocyte_physiolog1.39542283
49MP0005171_absent_coat_pigmentation1.38831240
50MP0000604_amyloidosis1.37575187
51MP0003828_pulmonary_edema1.36778988
52MP0005451_abnormal_body_composition1.36257561
53MP0002132_abnormal_respiratory_system1.33343297
54MP0008469_abnormal_protein_level1.33024272
55MP0002722_abnormal_immune_system1.31504141
56MP0008260_abnormal_autophagy1.29525979
57MP0003866_abnormal_defecation1.28570762
58MP0004510_myositis1.28009892
59MP0003183_abnormal_peptide_metabolism1.25880330
60MP0002295_abnormal_pulmonary_circulatio1.25015232
61MP0004782_abnormal_surfactant_physiolog1.24554815
62MP0005390_skeleton_phenotype1.21868743
63MP0008004_abnormal_stomach_pH1.21340445
64MP0004883_abnormal_blood_vessel1.18340716
65MP0003806_abnormal_nucleotide_metabolis1.18290593
66MP0002006_tumorigenesis1.16133758
67MP0005166_decreased_susceptibility_to1.16057904
68MP0002933_joint_inflammation1.15995578
69MP0005408_hypopigmentation1.14733275
70MP0003566_abnormal_cell_adhesion1.13290800
71MP0005023_abnormal_wound_healing1.12288935
72MP0003195_calcinosis1.10523928
73MP0001542_abnormal_bone_strength1.07358754
74MP0001879_abnormal_lymphatic_vessel1.07326957
75MP0000465_gastrointestinal_hemorrhage1.06932602
76MP0003279_aneurysm1.06110854
77MP0004381_abnormal_hair_follicle1.05551396
78MP0000249_abnormal_blood_vessel1.05418729
79MP0003300_gastrointestinal_ulcer1.05253789
80MP0000703_abnormal_thymus_morphology1.05225549
81MP0010678_abnormal_skin_adnexa1.05023529
82MP0003172_abnormal_lysosome_physiology1.03412748
83MP0009278_abnormal_bone_marrow1.01412771
84MP0000716_abnormal_immune_system1.01005661
85MP0000767_abnormal_smooth_muscle1.00709820
86MP0000383_abnormal_hair_follicle0.99652672
87MP0009763_increased_sensitivity_to0.99207594
88MP0001958_emphysema0.99027053
89MP0004272_abnormal_basement_membrane0.97923788
90MP0005310_abnormal_salivary_gland0.96057574
91MP0002138_abnormal_hepatobiliary_system0.95043070
92MP0003091_abnormal_cell_migration0.91119764
93MP0003656_abnormal_erythrocyte_physiolo0.89768530
94MP0001663_abnormal_digestive_system0.87592053
95MP0005275_abnormal_skin_tensile0.83099826
96MP0002060_abnormal_skin_morphology0.82491980
97MP0001216_abnormal_epidermal_layer0.81866126
98MP0001873_stomach_inflammation0.80912492
99MP0002166_altered_tumor_susceptibility0.80602738
100MP0002277_abnormal_respiratory_mucosa0.80340735
101MP0002139_abnormal_hepatobiliary_system0.79835725
102MP0005165_increased_susceptibility_to0.78045950
103MP0002332_abnormal_exercise_endurance0.77961279
104MP0002429_abnormal_blood_cell0.77522498
105MP0009765_abnormal_xenobiotic_induced0.76482706
106MP0001545_abnormal_hematopoietic_system0.74567686
107MP0005397_hematopoietic_system_phenotyp0.74567686
108MP0001243_abnormal_dermal_layer0.74396639
109MP0002396_abnormal_hematopoietic_system0.73505483
110MP0002398_abnormal_bone_marrow0.73384091
111MP0003136_yellow_coat_color0.73271575
112MP0000490_abnormal_crypts_of0.72134824
113MP0010368_abnormal_lymphatic_system0.71862328
114MP0003045_fibrosis0.71524156
115MP0000647_abnormal_sebaceous_gland0.71306644
116MP0000689_abnormal_spleen_morphology0.71195739
117MP0002136_abnormal_kidney_physiology0.70005276
118MP0003795_abnormal_bone_structure0.68376690
119MP0008874_decreased_physiological_sensi0.65670607
120MP0004808_abnormal_hematopoietic_stem0.63999189
121MP0003221_abnormal_cardiomyocyte_apopto0.60412277
122MP0005319_abnormal_enzyme/_coenzyme0.58558344
123MP0000609_abnormal_liver_physiology0.54414764
124MP0005076_abnormal_cell_differentiation0.51645704
125MP0002877_abnormal_melanocyte_morpholog0.48848295

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.94076883
2Eczematoid dermatitis (HP:0000976)5.61555414
3Recurrent bacterial skin infections (HP:0005406)5.38330406
4Axonal loss (HP:0003447)4.88950363
5Abnormality of macrophages (HP:0004311)4.84811242
6Recurrent gram-negative bacterial infections (HP:0005420)4.76585152
7Vacuolated lymphocytes (HP:0001922)4.67361247
8Gastrointestinal infarctions (HP:0005244)3.92349444
9Systemic lupus erythematosus (HP:0002725)3.89833222
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.85889199
11Increased cerebral lipofuscin (HP:0011813)3.81364162
12Meningitis (HP:0001287)3.63924744
13Parakeratosis (HP:0001036)3.62906911
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.58467872
15T lymphocytopenia (HP:0005403)3.50590055
16Myositis (HP:0100614)3.47166643
17Elevated erythrocyte sedimentation rate (HP:0003565)3.44956533
18Stomatitis (HP:0010280)3.44879578
19Orchitis (HP:0100796)3.44659864
20Encephalitis (HP:0002383)3.41877529
21Recurrent skin infections (HP:0001581)3.40106696
22Abnormality of T cell number (HP:0011839)3.36542733
23Mediastinal lymphadenopathy (HP:0100721)3.31265682
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.28955885
25Increased IgE level (HP:0003212)3.20371477
26Hepatosplenomegaly (HP:0001433)3.09091746
27Optic neuritis (HP:0100653)3.09070567
28Retrobulbar optic neuritis (HP:0100654)3.09070567
29Osteolytic defects of the phalanges of the hand (HP:0009771)3.08971817
30Osteolytic defects of the hand bones (HP:0009699)3.08971817
31Increased IgM level (HP:0003496)3.08631040
32Autoimmune thrombocytopenia (HP:0001973)3.07296282
33Myocardial infarction (HP:0001658)3.05232737
34Thick nail (HP:0001805)3.02265629
35Gingivitis (HP:0000230)2.93081452
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.93013797
37Abnormality of liposaccharide metabolism (HP:0010968)2.88154811
38Abnormality of glycosphingolipid metabolism (HP:0004343)2.88154811
39Abnormality of glycolipid metabolism (HP:0010969)2.88154811
40Chronic obstructive pulmonary disease (HP:0006510)2.87782957
41Obstructive lung disease (HP:0006536)2.87782957
42Chronic mucocutaneous candidiasis (HP:0002728)2.87224056
43Recurrent cutaneous fungal infections (HP:0011370)2.87224056
44Pustule (HP:0200039)2.84665776
45Anorexia (HP:0002039)2.84124859
46Arterial thrombosis (HP:0004420)2.81906670
47Interstitial pulmonary disease (HP:0006530)2.76372545
48Chest pain (HP:0100749)2.74860783
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.68478320
50Neurofibrillary tangles (HP:0002185)2.68406555
51Dysostosis multiplex (HP:0000943)2.66892729
52Disinhibition (HP:0000734)2.62981983
53Episodic fever (HP:0001954)2.60486143
54Spontaneous hematomas (HP:0007420)2.52197717
55Recurrent fungal infections (HP:0002841)2.52195728
56Abnormality of T cells (HP:0002843)2.51395379
57Congenital ichthyosiform erythroderma (HP:0007431)2.50050474
58Glomerulonephritis (HP:0000099)2.43689819
59Abnormality of the pleura (HP:0002103)2.43381987
60Vasculitis (HP:0002633)2.41045496
61Premature rupture of membranes (HP:0001788)2.39744453
62Inflammation of the large intestine (HP:0002037)2.38354547
63Prostate neoplasm (HP:0100787)2.37577524
64Vertebral compression fractures (HP:0002953)2.35565149
65Loss of speech (HP:0002371)2.34260317
66Cellulitis (HP:0100658)2.33754719
67Urticaria (HP:0001025)2.33367333
68Hypochromic anemia (HP:0001931)2.31780542
69Prolonged bleeding time (HP:0003010)2.31023301
70Purpura (HP:0000979)2.31014945
71Amyloidosis (HP:0011034)2.27601910
72Basal ganglia calcification (HP:0002135)2.26509047
73Gastrointestinal inflammation (HP:0004386)2.26121870
74Prolonged neonatal jaundice (HP:0006579)2.24654228
75Gingival bleeding (HP:0000225)2.22908732
76Epistaxis (HP:0000421)2.22821791
77Recurrent pneumonia (HP:0006532)2.22398429
78Abnormality of the vasculature of the conjunctiva (HP:0008054)2.21859349
79Hypochromic microcytic anemia (HP:0004840)2.20642984
80Lymphopenia (HP:0001888)2.20340618
81Peritonitis (HP:0002586)2.19452444
82Poor head control (HP:0002421)2.19045399
83Premature loss of primary teeth (HP:0006323)2.18165815
84Recurrent bronchitis (HP:0002837)2.18131001
85Granulocytopenia (HP:0001913)2.17359060
86Glomerulopathy (HP:0100820)2.16632880
87Abnormality of cells of the lymphoid lineage (HP:0012140)2.12494356
88Abnormality of the peritoneum (HP:0002585)2.11282894
89Joint hemorrhage (HP:0005261)2.10625465
90Increased serum ferritin (HP:0003281)2.08460976
91Polyneuropathy (HP:0001271)2.08236217
92Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07424816
93Abnormality of the pericardium (HP:0001697)2.06969327
94Colitis (HP:0002583)2.06095116
95Osteomyelitis (HP:0002754)2.05868418
96Acne (HP:0001061)2.05149899
97Slow saccadic eye movements (HP:0000514)2.05111833
98Abnormality of the endocardium (HP:0004306)2.04034002
99Pulmonary infiltrates (HP:0002113)2.03824448
100Leukocytosis (HP:0001974)2.02418710
101Gastrointestinal stroma tumor (HP:0100723)2.01565653
102Vertigo (HP:0002321)2.00529799
103Hematochezia (HP:0002573)1.99657434
104Periodontitis (HP:0000704)1.97752600
105Keratitis (HP:0000491)1.97022070
106Abnormality of complement system (HP:0005339)1.96468674
107Recurrent viral infections (HP:0004429)1.95795165
108Joint swelling (HP:0001386)1.95368939
109Skin ulcer (HP:0200042)1.95322921
110* Peripheral demyelination (HP:0011096)1.94731759
111Mucopolysacchariduria (HP:0008155)1.93853866
112Urinary glycosaminoglycan excretion (HP:0003541)1.93853866
113Nephritis (HP:0000123)1.93767439
114Nasal polyposis (HP:0100582)1.91691843
115Petechiae (HP:0000967)1.91051784
116Autoimmune hemolytic anemia (HP:0001890)1.89491595
117Keratoconjunctivitis sicca (HP:0001097)1.88502502
118Anhidrosis (HP:0000970)1.87633329
119White forelock (HP:0002211)1.87028421
120Arthralgia (HP:0002829)1.86601088
121Gangrene (HP:0100758)1.85779000
122Conjunctival telangiectasia (HP:0000524)1.85407787
123Abnormality of iron homeostasis (HP:0011031)1.83072769
124Hypergammaglobulinemia (HP:0010702)1.83000407
125Tetraparesis (HP:0002273)1.82551365
126Bone pain (HP:0002653)1.81607691
127Sepsis (HP:0100806)1.80314322
128Pathologic fracture (HP:0002756)1.79135991
129Patchy hypopigmentation of hair (HP:0011365)1.78067791
130* Segmental peripheral demyelination/remyelination (HP:0003481)1.78013775
131Esophageal varix (HP:0002040)1.77450949
132Pulmonary embolism (HP:0002204)1.77126219
133Erythroderma (HP:0001019)1.76081108
134Stridor (HP:0010307)1.75287481
135Vascular calcification (HP:0004934)1.74327347
136Chronic otitis media (HP:0000389)1.73369596
137Recurrent lower respiratory tract infections (HP:0002783)1.72964623
138Eosinophilia (HP:0001880)1.71578140
139Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71367055
140Abnormality of polysaccharide metabolism (HP:0011012)1.71367055
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71367055
142Hemoptysis (HP:0002105)1.70679067
143Keratoconjunctivitis (HP:0001096)1.70581809

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.06200758
2PBK4.05753095
3BLK3.35978882
4EPHB13.19347239
5TBK12.80352532
6MST42.60945229
7IRAK42.34099284
8IRAK32.26280088
9PIM22.19484795
10IKBKB2.13613201
11PRPF4B2.08974211
12TAOK12.08211119
13TYK21.97765942
14IKBKE1.92184483
15TRPM71.89013171
16FES1.82323773
17STK391.77177069
18MET1.76293553
19RIPK41.75048413
20GRK61.74551189
21ERN11.67690343
22TAOK21.62554546
23SIK31.54519386
24TGFBR21.54297306
25KIT1.49969582
26EPHA21.49943272
27TESK21.46902502
28TNK21.46596993
29MAPKAPK51.42477540
30CLK11.40287508
31BMX1.39887629
32MAP4K11.36672519
33MST1R1.35351511
34PKN11.33999179
35MAP3K11.32246753
36JAK31.31744186
37TXK1.31665142
38CSK1.28748675
39STK101.27583131
40LIMK11.25615780
41NME21.23928187
42ABL21.22414642
43CHUK1.21182473
44NEK91.20630060
45MAP2K21.20042307
46FGR1.17188305
47IRAK21.14739866
48KDR1.14730979
49MAP3K31.12557779
50TESK11.11558268
51BMPR21.05484404
52JAK11.04960989
53BMPR1B1.02668481
54BCR1.00805413
55TEC0.99826550
56TIE10.99713429
57KSR20.99422813
58CDC42BPA0.95199975
59PIM10.92186182
60OXSR10.89166920
61CSF1R0.88368103
62EIF2AK20.81474163
63HCK0.81472474
64EPHA30.81287233
65STK40.80704880
66NEK60.80518363
67ZAP700.78700931
68LCK0.77663853
69BTK0.77253990
70LRRK20.76639086
71MAP3K50.76508950
72ITK0.76156175
73ABL10.76124763
74LYN0.73414310
75FGFR30.72462269
76PDK10.71315760
77PDK20.70984161
78TRIB30.68862467
79RPS6KA40.68537162
80MARK20.67644114
81MARK30.67543336
82GSK3A0.67261819
83PRKCD0.66863811
84SMG10.66793422
85PDPK10.65265659
86FGFR40.65251136
87MAP3K20.64705554
88PRKCQ0.63174701
89STK30.62833700
90MATK0.61884645
91MAPKAPK20.61690865
92NUAK10.60334618
93ERBB40.60125677
94PAK40.60036319
95FYN0.58710112
96NLK0.58620689
97SIK10.58549627
98PTK60.58378697
99MAP2K30.57975126
100TAOK30.57960997
101MAP3K60.57141779
102EIF2AK30.57085553
103JAK20.55655747
104PRKD20.53764030
105SIK20.52960020
106MAP3K110.51454160
107RPS6KA50.51442055
108MOS0.51342018
109EGFR0.51059540
110HIPK20.50793964
111SYK0.49814125
112RIPK10.49671499
113MAP2K60.49127289
114DMPK0.47995571
115IRAK10.47850427
116CSNK1A1L0.47688285
117ERBB30.47596346
118DYRK1B0.45254236
119DYRK30.44801963
120GRK70.44497136
121PRKD10.43854786
122MAP3K130.43273292
123DDR20.41787166
124ACVR1B0.41292354
125CDK190.40299544
126DAPK30.40060094
127RPS6KC10.39949983
128RPS6KL10.39949983
129PIK3CG0.37537126
130MAPK70.37267771
131PRKG20.36857035
132CDK60.36610354
133SGK30.36556421
134PDGFRB0.36279751
135YES10.35895459
136KSR10.31767182
137RPS6KA60.31489950
138STK380.29498751
139STK240.28691539
140MAPK120.28425970
141MAP3K80.28265200

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.03639842
2Graft-versus-host disease_Homo sapiens_hsa053322.78815881
3Leishmaniasis_Homo sapiens_hsa051402.74433757
4Malaria_Homo sapiens_hsa051442.49174756
5Steroid biosynthesis_Homo sapiens_hsa001002.32790130
6Rheumatoid arthritis_Homo sapiens_hsa053232.27796034
7Pertussis_Homo sapiens_hsa051332.20016262
8Legionellosis_Homo sapiens_hsa051342.15797821
9* Lysosome_Homo sapiens_hsa041422.13194802
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.11084826
11Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11004764
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99676357
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.93606071
14Allograft rejection_Homo sapiens_hsa053301.89785754
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87300136
16Phagosome_Homo sapiens_hsa041451.85127898
17Osteoclast differentiation_Homo sapiens_hsa043801.84674554
18Salmonella infection_Homo sapiens_hsa051321.80321931
19Tuberculosis_Homo sapiens_hsa051521.68998536
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.61257401
21Asthma_Homo sapiens_hsa053101.57407293
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54099071
23Other glycan degradation_Homo sapiens_hsa005111.53108444
24TNF signaling pathway_Homo sapiens_hsa046681.51243891
25Hematopoietic cell lineage_Homo sapiens_hsa046401.50855352
26Complement and coagulation cascades_Homo sapiens_hsa046101.46600046
27Acute myeloid leukemia_Homo sapiens_hsa052211.41260412
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.39326089
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38238113
30Histidine metabolism_Homo sapiens_hsa003401.38089990
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.38084461
32Measles_Homo sapiens_hsa051621.36972427
33Fatty acid elongation_Homo sapiens_hsa000621.36862311
34Shigellosis_Homo sapiens_hsa051311.36071162
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.35741068
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.35665476
37Toxoplasmosis_Homo sapiens_hsa051451.28188734
38Ether lipid metabolism_Homo sapiens_hsa005651.26872601
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25550840
40Sphingolipid metabolism_Homo sapiens_hsa006001.21749084
41African trypanosomiasis_Homo sapiens_hsa051431.19168390
42Apoptosis_Homo sapiens_hsa042101.17797589
43Influenza A_Homo sapiens_hsa051641.16832946
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09831112
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07287268
46Autoimmune thyroid disease_Homo sapiens_hsa053201.05115146
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.04500607
48Amoebiasis_Homo sapiens_hsa051461.00272405
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.98829093
50Chemokine signaling pathway_Homo sapiens_hsa040620.98363751
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97902743
52Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95834383
53B cell receptor signaling pathway_Homo sapiens_hsa046620.93415631
54Viral myocarditis_Homo sapiens_hsa054160.92634648
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90528835
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89272337
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89152092
58Mineral absorption_Homo sapiens_hsa049780.88388101
59Protein export_Homo sapiens_hsa030600.85879692
60Hepatitis C_Homo sapiens_hsa051600.84134070
61Antigen processing and presentation_Homo sapiens_hsa046120.83909346
62Pancreatic cancer_Homo sapiens_hsa052120.82987424
63Non-small cell lung cancer_Homo sapiens_hsa052230.82362254
64Arachidonic acid metabolism_Homo sapiens_hsa005900.81320647
65VEGF signaling pathway_Homo sapiens_hsa043700.80747217
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80676515
67Herpes simplex infection_Homo sapiens_hsa051680.80286241
68Prolactin signaling pathway_Homo sapiens_hsa049170.79920861
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78486276
70Glutathione metabolism_Homo sapiens_hsa004800.78257765
71Epstein-Barr virus infection_Homo sapiens_hsa051690.77877267
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77377715
73Chronic myeloid leukemia_Homo sapiens_hsa052200.76144546
74Type I diabetes mellitus_Homo sapiens_hsa049400.75792242
75Folate biosynthesis_Homo sapiens_hsa007900.75258852
76Vitamin digestion and absorption_Homo sapiens_hsa049770.74369802
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74270478
78Sulfur metabolism_Homo sapiens_hsa009200.73503291
79Chemical carcinogenesis_Homo sapiens_hsa052040.72672060
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71366342
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.70395087
82Prion diseases_Homo sapiens_hsa050200.69214017
83Caffeine metabolism_Homo sapiens_hsa002320.67530177
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.63751415
85Hepatitis B_Homo sapiens_hsa051610.62943741
86Retinol metabolism_Homo sapiens_hsa008300.61579153
87ECM-receptor interaction_Homo sapiens_hsa045120.61186787
88Notch signaling pathway_Homo sapiens_hsa043300.59831741
89Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56703159
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56443732
91Linoleic acid metabolism_Homo sapiens_hsa005910.56022972
92Viral carcinogenesis_Homo sapiens_hsa052030.54454632
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.53827006
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.53659094
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53307040
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53187156
97FoxO signaling pathway_Homo sapiens_hsa040680.53155202
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52003990
99HTLV-I infection_Homo sapiens_hsa051660.51833142
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49015061
101HIF-1 signaling pathway_Homo sapiens_hsa040660.47799008
102Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47701359
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47646718
104Small cell lung cancer_Homo sapiens_hsa052220.46099999
105Endocytosis_Homo sapiens_hsa041440.45572610
106Bladder cancer_Homo sapiens_hsa052190.44890087
107Platelet activation_Homo sapiens_hsa046110.43354514
108Primary immunodeficiency_Homo sapiens_hsa053400.42577361
109Insulin resistance_Homo sapiens_hsa049310.42501847
110Proteoglycans in cancer_Homo sapiens_hsa052050.42046762
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.39984510
112Vibrio cholerae infection_Homo sapiens_hsa051100.39927743
113Endometrial cancer_Homo sapiens_hsa052130.37494255
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37451754
115Dorso-ventral axis formation_Homo sapiens_hsa043200.36352940
116Adherens junction_Homo sapiens_hsa045200.35870150
117Collecting duct acid secretion_Homo sapiens_hsa049660.34606248
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34291245
119Focal adhesion_Homo sapiens_hsa045100.33543521
120Arginine and proline metabolism_Homo sapiens_hsa003300.32029395
121Prostate cancer_Homo sapiens_hsa052150.31925388
122Type II diabetes mellitus_Homo sapiens_hsa049300.31540534
123T cell receptor signaling pathway_Homo sapiens_hsa046600.30984074
124Renal cell carcinoma_Homo sapiens_hsa052110.30925753
125MAPK signaling pathway_Homo sapiens_hsa040100.29663122
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29454827
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29099568
128Choline metabolism in cancer_Homo sapiens_hsa052310.27478066
129GnRH signaling pathway_Homo sapiens_hsa049120.26799712
130Rap1 signaling pathway_Homo sapiens_hsa040150.24104425
131mTOR signaling pathway_Homo sapiens_hsa041500.23790458
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23340969
133ErbB signaling pathway_Homo sapiens_hsa040120.22653530

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