LIPJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of uterine smooth muscle contraction (GO:0070474)9.52726763
2cellular zinc ion homeostasis (GO:0006882)8.37503818
3actin filament depolymerization (GO:0030042)8.29675911
4positive regulation of gamma-delta T cell activation (GO:0046645)8.09683543
5positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)7.77626726
6regulation of uterine smooth muscle contraction (GO:0070472)7.41097128
7regulation of gamma-delta T cell differentiation (GO:0045586)7.25204911
8zinc ion homeostasis (GO:0055069)6.73341024
9monoubiquitinated protein deubiquitination (GO:0035520)6.26849598
10organelle membrane fusion (GO:0090174)6.22876056
11regulation of gamma-delta T cell activation (GO:0046643)6.09185950
12lens fiber cell development (GO:0070307)5.78745510
13positive regulation of gluconeogenesis (GO:0045722)5.74401130
14basement membrane organization (GO:0071711)5.71530597
15protein K11-linked deubiquitination (GO:0035871)5.70461136
16fucosylation (GO:0036065)5.57939890
17cilium or flagellum-dependent cell motility (GO:0001539)5.52016730
18peptidyl-glutamic acid carboxylation (GO:0017187)5.51004863
19protein carboxylation (GO:0018214)5.51004863
20regulation of developmental pigmentation (GO:0048070)5.47280735
21cilium movement (GO:0003341)5.47264817
22cerebellar granule cell differentiation (GO:0021707)5.46526186
23fat-soluble vitamin biosynthetic process (GO:0042362)5.43514886
24axonemal dynein complex assembly (GO:0070286)5.42515350
25regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)5.29535350
26cell migration involved in gastrulation (GO:0042074)5.22628685
27lysosome localization (GO:0032418)5.11537956
28protein K48-linked deubiquitination (GO:0071108)5.09063285
29regulation of T cell receptor signaling pathway (GO:0050856)5.05920475
30antigen processing and presentation via MHC class Ib (GO:0002475)4.82418801
31RNA destabilization (GO:0050779)4.79910010
32cellular response to nitric oxide (GO:0071732)4.76168243
33positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.57086390
34epithelial cilium movement (GO:0003351)4.45212883
35asymmetric protein localization (GO:0008105)4.41325143
36epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39503866
37negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.35588041
38melanosome localization (GO:0032400)4.31626416
39negative regulation of DNA repair (GO:0045738)4.25057745
40pigment granule localization (GO:0051875)4.18325656
41regulation of energy homeostasis (GO:2000505)4.14988243
42endosome to melanosome transport (GO:0035646)4.09583862
43endosome to pigment granule transport (GO:0043485)4.09583862
44sex differentiation (GO:0007548)3.99837086
45cell proliferation in forebrain (GO:0021846)3.95259920
46positive regulation of intrinsic apoptotic signaling pathway (GO:2001244)3.90533014
47platelet formation (GO:0030220)3.88609190
48negative regulation of toll-like receptor signaling pathway (GO:0034122)3.87968406
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.82545617
50positive regulation of smooth muscle contraction (GO:0045987)3.70457752
51negative regulation of T cell apoptotic process (GO:0070233)3.67178553
52protein depolymerization (GO:0051261)3.66192867
53negative regulation of thymocyte apoptotic process (GO:0070244)3.64145328
54cellular response to reactive nitrogen species (GO:1902170)3.61476399
55negative regulation of skeletal muscle tissue development (GO:0048642)3.61299419
56negative regulation of macrophage differentiation (GO:0045650)3.58910319
57regulation of defense response to virus by virus (GO:0050690)3.55033207
58mitotic nuclear envelope reassembly (GO:0007084)3.51801815
59nuclear envelope reassembly (GO:0031468)3.51801815
60regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.51410427
61peptidyl-lysine dimethylation (GO:0018027)3.50786032
62CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.49969743
63peptidyl-glutamic acid modification (GO:0018200)3.49413867
64negative regulation of circadian rhythm (GO:0042754)3.43026176
65vitamin D metabolic process (GO:0042359)3.36965247
66protein neddylation (GO:0045116)3.36621149
67regulation of germinal center formation (GO:0002634)3.32483673
68regulation of toll-like receptor signaling pathway (GO:0034121)3.31410407
69imidazole-containing compound metabolic process (GO:0052803)3.25346209
70negative regulation of T cell differentiation in thymus (GO:0033085)3.23733063
71ventricular system development (GO:0021591)3.22914614
72response to nitric oxide (GO:0071731)3.22151205
73protein K63-linked deubiquitination (GO:0070536)3.20706962
74phosphorelay signal transduction system (GO:0000160)3.17318598
75ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.13381584
76B cell receptor signaling pathway (GO:0050853)3.12143693
77protein targeting to vacuole (GO:0006623)3.09347161
78protein targeting to lysosome (GO:0006622)3.09347161
79establishment of protein localization to vacuole (GO:0072666)3.09347161
80motile cilium assembly (GO:0044458)3.08508192
81negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.06051861
82melanosome organization (GO:0032438)3.04837211
83axoneme assembly (GO:0035082)3.04065865
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.98006910
85vesicle docking involved in exocytosis (GO:0006904)2.95922915
86positive regulation of muscle contraction (GO:0045933)2.94889149
87regulation of B cell apoptotic process (GO:0002902)2.94856604
88somatic stem cell division (GO:0048103)2.91940740
89protein localization to lysosome (GO:0061462)2.91687192
90protein localization to vacuole (GO:0072665)2.91687192
91pigment granule organization (GO:0048753)2.91257990
92regulation of T cell differentiation in thymus (GO:0033081)2.89603664
93purine deoxyribonucleotide catabolic process (GO:0009155)2.87887860
94interferon-gamma production (GO:0032609)2.86474274
95anterograde synaptic vesicle transport (GO:0048490)2.86255041
96histone deubiquitination (GO:0016578)2.83295475
97N-acetylglucosamine metabolic process (GO:0006044)2.82967016
98regulation of penile erection (GO:0060405)2.82383412
99activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.81798984
100tolerance induction (GO:0002507)12.1310859

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.96693704
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.37392790
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09347640
4FLI1_27457419_Chip-Seq_LIVER_Mouse2.87954515
5AR_21572438_ChIP-Seq_LNCaP_Human2.85307683
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.80810636
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.55314170
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.53211273
9VDR_22108803_ChIP-Seq_LS180_Human2.36136704
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36089471
11IRF1_19129219_ChIP-ChIP_H3396_Human2.18901009
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.14471245
13EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02644336
14FUS_26573619_Chip-Seq_HEK293_Human1.89911843
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87149577
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80746981
17TP53_16413492_ChIP-PET_HCT116_Human1.80549213
18FOXA1_27270436_Chip-Seq_PROSTATE_Human1.80308132
19FOXA1_25329375_ChIP-Seq_VCAP_Human1.80308132
20TCF4_23295773_ChIP-Seq_U87_Human1.69622859
21STAT3_23295773_ChIP-Seq_U87_Human1.64853901
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62504687
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.62032801
24FOXA1_21572438_ChIP-Seq_LNCaP_Human1.59406097
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.58837496
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58369519
27ER_23166858_ChIP-Seq_MCF-7_Human1.54068029
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.53829606
29TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52053674
30POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52053674
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.51872104
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51520910
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.49112440
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.48227560
35SCL_19346495_ChIP-Seq_HPC-7_Human1.47541346
36* CBP_21632823_ChIP-Seq_H3396_Human1.44349862
37RXR_22108803_ChIP-Seq_LS180_Human1.41217062
38NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41115297
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41102612
40SMAD4_21799915_ChIP-Seq_A2780_Human1.37474177
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35653368
42TP53_22573176_ChIP-Seq_HFKS_Human1.35614092
43ZNF274_21170338_ChIP-Seq_K562_Hela1.34344163
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33355136
45DROSHA_22980978_ChIP-Seq_HELA_Human1.30406381
46EZH2_22144423_ChIP-Seq_EOC_Human1.29063601
47TAF15_26573619_Chip-Seq_HEK293_Human1.25599590
48P300_19829295_ChIP-Seq_ESCs_Human1.25083680
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.24834276
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24779203
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23558720
52STAT1_20625510_ChIP-Seq_HELA_Human1.22947077
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.19588531
54LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18780160
55NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.18722673
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17221057
57IGF1R_20145208_ChIP-Seq_DFB_Human1.16636043
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16568678
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.14958928
60EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14561639
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13628303
62OCT1_27270436_Chip-Seq_PROSTATE_Human1.11545015
63REST_21632747_ChIP-Seq_MESCs_Mouse1.11108932
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.09691508
65OCT4_18555785_Chip-Seq_ESCs_Mouse1.09245427
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.08618506
67GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08125430
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07334618
69RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.07205745
70SMRT_27268052_Chip-Seq_Bcells_Human1.05450281
71LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05174497
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04812570
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03949111
74RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03497215
75TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03259886
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03179987
77SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02929000
78GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02620072
79AR_25329375_ChIP-Seq_VCAP_Human1.02308521
80TAF2_19829295_ChIP-Seq_ESCs_Human1.01708637
81AR_19668381_ChIP-Seq_PC3_Human1.01426905
82OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01332883
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00539248
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.00492183
85TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99116196
86BCAT_22108803_ChIP-Seq_LS180_Human0.98868869
87ERG_20517297_ChIP-Seq_VCAP_Human0.98467577
88KLF4_18555785_Chip-Seq_ESCs_Mouse0.97406047
89AR_20517297_ChIP-Seq_VCAP_Human0.96765044
90GATA1_19941826_ChIP-Seq_K562_Human0.96623042
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96611418
92CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96054573
93TP53_18474530_ChIP-ChIP_U2OS_Human0.95702193
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95250147
95STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93372959
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93104050
97SMAD3_21741376_ChIP-Seq_EPCs_Human0.92570808
98ESRRB_18555785_Chip-Seq_ESCs_Mouse0.91865659
99MYB_26560356_Chip-Seq_TH2_Human0.91430864
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91424367

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.24320743
2MP0005075_abnormal_melanosome_morpholog6.78564923
3MP0005408_hypopigmentation6.46687444
4MP0002653_abnormal_ependyma_morphology6.44056965
5MP0000371_diluted_coat_color3.75934358
6MP0005174_abnormal_tail_pigmentation3.30198594
7MP0000015_abnormal_ear_pigmentation3.17722494
8MP0000566_synostosis2.92068062
9MP0009697_abnormal_copulation2.90351244
10MP0008007_abnormal_cellular_replicative2.74679143
11MP0003890_abnormal_embryonic-extraembry2.50664191
12MP0003763_abnormal_thymus_physiology2.20199879
13MP0003172_abnormal_lysosome_physiology2.03253653
14MP0005464_abnormal_platelet_physiology1.93406105
15MP0010234_abnormal_vibrissa_follicle1.88157533
16MP0000747_muscle_weakness1.86199365
17MP0009046_muscle_twitch1.85301872
18MP0005167_abnormal_blood-brain_barrier1.76222111
19MP0003879_abnormal_hair_cell1.75565279
20MP0002075_abnormal_coat/hair_pigmentati1.72860904
21MP0001919_abnormal_reproductive_system1.69409867
22MP0006035_abnormal_mitochondrial_morpho1.66556091
23MP0001293_anophthalmia1.59731355
24MP0001324_abnormal_eye_pigmentation1.57037361
25MP0005623_abnormal_meninges_morphology1.52453227
26MP0002095_abnormal_skin_pigmentation1.46679014
27MP0003950_abnormal_plasma_membrane1.40580821
28MP0002269_muscular_atrophy1.40443708
29MP0010678_abnormal_skin_adnexa1.36098389
30MP0001485_abnormal_pinna_reflex1.36013211
31MP0003252_abnormal_bile_duct1.35467650
32MP0004484_altered_response_of1.29376526
33MP0003646_muscle_fatigue1.29352617
34MP0000383_abnormal_hair_follicle1.12414272
35MP0001186_pigmentation_phenotype1.11362895
36MP0004130_abnormal_muscle_cell1.09904830
37MP0002089_abnormal_postnatal_growth/wei1.04730439
38MP0002332_abnormal_exercise_endurance1.00916217
39MP0008875_abnormal_xenobiotic_pharmacok1.00325906
40MP0003698_abnormal_male_reproductive0.97162516
41MP0005389_reproductive_system_phenotype0.93709594
42MP0002184_abnormal_innervation0.91439722
43MP0003880_abnormal_central_pattern0.90223055
44MP0001661_extended_life_span0.89723947
45MP0003011_delayed_dark_adaptation0.88471108
46MP0003183_abnormal_peptide_metabolism0.83497300
47MP0000703_abnormal_thymus_morphology0.80784145
48MP0001486_abnormal_startle_reflex0.74213890
49MP0004145_abnormal_muscle_electrophysio0.74201040
50MP0005410_abnormal_fertilization0.73174118
51MP0000358_abnormal_cell_content/0.72769189
52MP0001501_abnormal_sleep_pattern0.71881542
53MP0003937_abnormal_limbs/digits/tail_de0.71111712
54MP0005423_abnormal_somatic_nervous0.70134547
55MP0002733_abnormal_thermal_nociception0.70004302
56MP0003119_abnormal_digestive_system0.69985002
57MP0002092_abnormal_eye_morphology0.69031521
58MP0001502_abnormal_circadian_rhythm0.68914173
59MP0006036_abnormal_mitochondrial_physio0.68529417
60MP0004133_heterotaxia0.68406058
61MP0002693_abnormal_pancreas_physiology0.67492082
62MP0002938_white_spotting0.66981545
63MP0001944_abnormal_pancreas_morphology0.66840712
64MP0001929_abnormal_gametogenesis0.66176755
65MP0002177_abnormal_outer_ear0.65479939
66MP0004036_abnormal_muscle_relaxation0.64665566
67MP0001970_abnormal_pain_threshold0.64534251
68MP0001177_atelectasis0.62844851
69MP0009745_abnormal_behavioral_response0.62515843
70MP0004742_abnormal_vestibular_system0.62448953
71MP0000750_abnormal_muscle_regeneration0.61069221
72MP0001348_abnormal_lacrimal_gland0.59604451
73MP0005058_abnormal_lysosome_morphology0.58796550
74MP0001800_abnormal_humoral_immune0.57312354
75MP0002064_seizures0.56221144
76MP0005266_abnormal_metabolism0.55710978
77MP0003959_abnormal_lean_body0.55695012
78MP0005391_vision/eye_phenotype0.55484668
79MP0004215_abnormal_myocardial_fiber0.54893431
80MP0002272_abnormal_nervous_system0.50636231
81MP0008877_abnormal_DNA_methylation0.49782443
82MP0001119_abnormal_female_reproductive0.47490561
83MP0000427_abnormal_hair_cycle0.46072300
84MP0005197_abnormal_uvea_morphology0.46031521
85MP0003633_abnormal_nervous_system0.45723106
86MP0009250_abnormal_appendicular_skeleto0.45404029
87MP0003718_maternal_effect0.44388991
88MP0006276_abnormal_autonomic_nervous0.44375769
89MP0008872_abnormal_physiological_respon0.44045082
90MP0001873_stomach_inflammation0.44042569
91MP0002136_abnormal_kidney_physiology0.43666334
92MP0002572_abnormal_emotion/affect_behav0.43628602
93MP0008995_early_reproductive_senescence0.43060021
94MP0010386_abnormal_urinary_bladder0.42916785
95MP0002452_abnormal_antigen_presenting0.42446415
96MP0002722_abnormal_immune_system0.42381393
97MP0009763_increased_sensitivity_to0.42340127
98MP0001664_abnormal_digestion0.41834160
99MP0001968_abnormal_touch/_nociception0.41702193
100MP0002210_abnormal_sex_determination0.40866507

Predicted human phenotypes

RankGene SetZ-score
1B lymphocytopenia (HP:0010976)9.28500737
2IgM deficiency (HP:0002850)9.07639192
3Abnormality of B cell number (HP:0010975)8.63560015
4Recurrent sinusitis (HP:0011108)6.53858353
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.50070119
6Oligodactyly (hands) (HP:0001180)5.55791895
7IgA deficiency (HP:0002720)4.62341700
8Gastrointestinal stroma tumor (HP:0100723)4.48185423
9Recurrent bronchitis (HP:0002837)4.45309660
10Abnormal ciliary motility (HP:0012262)4.38422185
11Fibular aplasia (HP:0002990)4.33131368
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.18238432
13Absent/shortened dynein arms (HP:0200106)4.18238432
14Abnormality of alanine metabolism (HP:0010916)4.00825086
15Hyperalaninemia (HP:0003348)4.00825086
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.00825086
17Abnormal respiratory motile cilium physiology (HP:0012261)3.99944565
18Split foot (HP:0001839)3.96598334
19Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.95603658
20IgG deficiency (HP:0004315)3.90459050
21Chronic hepatic failure (HP:0100626)3.74950817
22Bronchitis (HP:0012387)3.72106884
23Hypoplastic pelvis (HP:0008839)3.66845436
24Bronchiectasis (HP:0002110)3.63704171
25Adactyly (HP:0009776)3.62070008
26Synostosis involving the elbow (HP:0003938)3.55442131
27Humeroradial synostosis (HP:0003041)3.55442131
28Oligodactyly (HP:0012165)3.52572432
29Rhinitis (HP:0012384)3.34081302
30Albinism (HP:0001022)3.32671593
31Abnormality of T cell physiology (HP:0011840)3.16101621
32Abnormal respiratory motile cilium morphology (HP:0005938)3.12365828
33Abnormal respiratory epithelium morphology (HP:0012253)3.12365828
34Autoimmune thrombocytopenia (HP:0001973)3.05754694
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.01142316
36Posterior subcapsular cataract (HP:0007787)3.00918829
37Thin bony cortex (HP:0002753)2.97747485
38Femoral bowing (HP:0002980)2.94699323
39Autoimmune hemolytic anemia (HP:0001890)2.93861267
40Recurrent otitis media (HP:0000403)2.93307673
41Abnormality of the peritoneum (HP:0002585)2.92913829
42Abnormal finger flexion creases (HP:0006143)2.84971510
43Radial bowing (HP:0002986)2.81711305
44Nasal polyposis (HP:0100582)2.76738739
45Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.74736262
46Gonadotropin excess (HP:0000837)2.72692581
47Occipital encephalocele (HP:0002085)2.70232119
48Chronic bronchitis (HP:0004469)2.65630119
49Enlarged epiphyses (HP:0010580)2.65261976
50Neoplasm of head and neck (HP:0012288)2.58269148
51Esophageal neoplasm (HP:0100751)2.58269148
52Lymphopenia (HP:0001888)2.56467874
53Increased intramyocellular lipid droplets (HP:0012240)2.55675181
54Severe visual impairment (HP:0001141)2.52235611
55Symphalangism affecting the phalanges of the hand (HP:0009773)2.50453254
56Recurrent pneumonia (HP:0006532)2.49116582
57Delayed epiphyseal ossification (HP:0002663)2.45555005
58Mediastinal lymphadenopathy (HP:0100721)2.45075833
59Aplasia/hypoplasia of the uterus (HP:0008684)2.43006799
60Broad ribs (HP:0000885)2.35482098
61Tubular atrophy (HP:0000092)2.31432555
62Elevated erythrocyte sedimentation rate (HP:0003565)2.30981062
63Abnormal biliary tract physiology (HP:0012439)2.29973163
64Bile duct proliferation (HP:0001408)2.29973163
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.28256519
66Pancreatic fibrosis (HP:0100732)2.27249909
67True hermaphroditism (HP:0010459)2.26355472
68Generalized hypopigmentation of hair (HP:0011358)2.19643991
69Barrel-shaped chest (HP:0001552)2.19234954
70Hepatocellular necrosis (HP:0001404)2.17453913
71Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.15260222
72Type 2 muscle fiber atrophy (HP:0003554)2.13967823
73Aplasia/Hypoplasia of the fibula (HP:0006492)2.12518219
74Abnormality of the nasal mucosa (HP:0000433)2.11585872
75Increased muscle lipid content (HP:0009058)2.09246698
76Abnormal drinking behavior (HP:0030082)2.09168762
77Polydipsia (HP:0001959)2.09168762
78Abnormality of the costochondral junction (HP:0000919)2.09132819
79Molar tooth sign on MRI (HP:0002419)2.08810477
80Abnormality of midbrain morphology (HP:0002418)2.08810477
81Fair hair (HP:0002286)2.08228371
82Hypoplastic iliac wings (HP:0002866)2.06023217
83Hypoplastic nipples (HP:0002557)2.05553110
84Hemivertebrae (HP:0002937)2.03753058
85Abnormality of the pubic bones (HP:0003172)2.02581347
86Widely patent fontanelles and sutures (HP:0004492)2.02156200
87Type II lissencephaly (HP:0007260)2.02082393
88Nephronophthisis (HP:0000090)2.00691070
89Stomatitis (HP:0010280)1.97091062
90Thyroiditis (HP:0100646)1.96104015
91Pancreatic cysts (HP:0001737)1.94625778
92Severe combined immunodeficiency (HP:0004430)1.90748107
93Abnormality of the fibula (HP:0002991)1.89260274
94Poor eye contact (HP:0000817)1.88794792
95Ocular albinism (HP:0001107)1.82008058
96Emphysema (HP:0002097)1.81995046
97Abnormality of T cells (HP:0002843)1.79250670
98Ragged-red muscle fibers (HP:0003200)1.78292822
99Subcapsular cataract (HP:0000523)1.78083935
100Muscle fiber atrophy (HP:0100295)1.77097863

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.44341051
2MAP3K135.25492370
3ARAF4.95112427
4NLK4.10286007
5CSNK1G13.90199186
6PRKCI2.93270276
7MAPK112.69486695
8EPHA32.55661553
9CSNK1G32.55094935
10CSNK1A1L2.47846658
11MOS2.42078759
12CSK2.33724752
13CSNK1G22.19365847
14PTK2B2.04108912
15SGK21.86683816
16KSR21.79247346
17FRK1.59755753
18BRAF1.47102371
19BMX1.44976525
20SGK2231.33433386
21SGK4941.33433386
22TEC1.31322673
23KSR11.28170344
24ADRBK21.23669618
25FGFR21.22210814
26GRK11.21908877
27SGK31.14424638
28TYRO31.12217601
29SYK1.09161481
30ITK1.04720011
31PNCK1.02778181
32CDK41.01945775
33IKBKE1.01794496
34RAF10.99445710
35IRAK10.96881989
36MAP3K40.96589233
37DAPK20.91383293
38MAPK150.91133315
39EPHA40.89834920
40JAK30.88743456
41FGFR40.87366354
42MET0.82905594
43ZAK0.79662097
44MAP2K70.76568661
45DYRK1A0.76425381
46RET0.76395813
47NTRK20.73945510
48BTK0.73217519
49STK30.72759307
50WNK40.71618819
51MAPK130.71571300
52LATS10.70089007
53OBSCN0.68886922
54PRKCG0.61355066
55CSF1R0.60563070
56ADRBK10.58240033
57MUSK0.54787690
58LCK0.53314745
59HCK0.53227764
60PDGFRB0.52563774
61MAPK100.52108612
62UHMK10.51593293
63INSRR0.51346692
64MAP2K40.50378966
65TBK10.50040826
66TNK20.50002533
67ATR0.46542391
68NEK60.43334905
69PIK3CA0.42933818
70TXK0.42145196
71PAK10.41028453
72PRKCA0.40165528
73MAP3K10.38697513
74MAP2K10.38558139
75STK390.37391997
76PIK3CG0.36953292
77FGR0.32598278
78CHEK20.32155455
79PRKCE0.31308809
80PHKG20.30286940
81PHKG10.30286940
82MAPK90.28734455
83FGFR30.28593425
84MAPK80.28296367
85PDK10.27428627
86PRKCZ0.27037735
87MAPK70.23466472
88PDPK10.21669900
89OXSR10.21458913
90NUAK10.19574169
91MAPK30.19549651
92CSNK1D0.18684321
93RPS6KA50.18521658
94CAMK40.18222927
95CSNK1A10.17887678
96GSK3B0.17391823
97GSK3A0.17181631
98INSR0.17106308
99PINK10.16684030
100CDK10.16097402

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053408.02891556
2T cell receptor signaling pathway_Homo sapiens_hsa046603.43436959
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.09561397
4Caffeine metabolism_Homo sapiens_hsa002322.58850826
5Linoleic acid metabolism_Homo sapiens_hsa005912.37560728
6Nicotine addiction_Homo sapiens_hsa050332.35435764
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.27575567
8Regulation of autophagy_Homo sapiens_hsa041402.22179197
9Nitrogen metabolism_Homo sapiens_hsa009102.06710004
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.04169823
11Steroid biosynthesis_Homo sapiens_hsa001002.00128810
12Basal transcription factors_Homo sapiens_hsa030221.88093400
13Selenocompound metabolism_Homo sapiens_hsa004501.86823923
14Fatty acid biosynthesis_Homo sapiens_hsa000611.81991360
15GABAergic synapse_Homo sapiens_hsa047271.79084186
16One carbon pool by folate_Homo sapiens_hsa006701.50626415
17Morphine addiction_Homo sapiens_hsa050321.46821619
18Dorso-ventral axis formation_Homo sapiens_hsa043201.45889304
19Hedgehog signaling pathway_Homo sapiens_hsa043401.40632275
20Systemic lupus erythematosus_Homo sapiens_hsa053221.40350315
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39360524
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38514610
23ABC transporters_Homo sapiens_hsa020101.22533722
24B cell receptor signaling pathway_Homo sapiens_hsa046621.18685337
25Basal cell carcinoma_Homo sapiens_hsa052171.18626946
26Glycerolipid metabolism_Homo sapiens_hsa005611.16404583
27Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16391835
28Oxytocin signaling pathway_Homo sapiens_hsa049211.13787305
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10952917
30Ether lipid metabolism_Homo sapiens_hsa005651.10847393
31Alcoholism_Homo sapiens_hsa050340.99804529
32Taste transduction_Homo sapiens_hsa047420.98828111
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98035260
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92489315
35NF-kappa B signaling pathway_Homo sapiens_hsa040640.91005542
36Vascular smooth muscle contraction_Homo sapiens_hsa042700.90537484
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86489504
38p53 signaling pathway_Homo sapiens_hsa041150.85372255
39Huntingtons disease_Homo sapiens_hsa050160.82413478
40Prion diseases_Homo sapiens_hsa050200.78847104
41Calcium signaling pathway_Homo sapiens_hsa040200.74228509
42HTLV-I infection_Homo sapiens_hsa051660.70940048
43VEGF signaling pathway_Homo sapiens_hsa043700.70347864
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69585772
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67362759
46Choline metabolism in cancer_Homo sapiens_hsa052310.66610833
47Hematopoietic cell lineage_Homo sapiens_hsa046400.65834801
48Proteasome_Homo sapiens_hsa030500.65197013
49Lysosome_Homo sapiens_hsa041420.64657462
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.64197431
51Olfactory transduction_Homo sapiens_hsa047400.60765049
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.60604815
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57473693
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56287079
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56070731
56Arachidonic acid metabolism_Homo sapiens_hsa005900.55966230
57FoxO signaling pathway_Homo sapiens_hsa040680.55716538
58Phototransduction_Homo sapiens_hsa047440.54651628
59Viral carcinogenesis_Homo sapiens_hsa052030.54322611
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52949483
61Ovarian steroidogenesis_Homo sapiens_hsa049130.52274633
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.51987773
63Glutamatergic synapse_Homo sapiens_hsa047240.51286239
64Axon guidance_Homo sapiens_hsa043600.50918148
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50082059
66Serotonergic synapse_Homo sapiens_hsa047260.49015679
67Long-term depression_Homo sapiens_hsa047300.47939143
68Cholinergic synapse_Homo sapiens_hsa047250.47286038
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45798522
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.45368850
71Chemokine signaling pathway_Homo sapiens_hsa040620.45218959
72Base excision repair_Homo sapiens_hsa034100.44775395
73Colorectal cancer_Homo sapiens_hsa052100.43919944
74Purine metabolism_Homo sapiens_hsa002300.43460827
75MAPK signaling pathway_Homo sapiens_hsa040100.42464751
76Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41525707
77Arginine and proline metabolism_Homo sapiens_hsa003300.41293106
78Circadian entrainment_Homo sapiens_hsa047130.40527649
79Fructose and mannose metabolism_Homo sapiens_hsa000510.40037478
80Hippo signaling pathway_Homo sapiens_hsa043900.38660669
81Alzheimers disease_Homo sapiens_hsa050100.36693220
82Bile secretion_Homo sapiens_hsa049760.36462250
83Histidine metabolism_Homo sapiens_hsa003400.36267599
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35269578
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34986184
86ErbB signaling pathway_Homo sapiens_hsa040120.34259509
87Melanogenesis_Homo sapiens_hsa049160.34228035
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.33697382
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33399372
90Gastric acid secretion_Homo sapiens_hsa049710.32281359
91Hepatitis B_Homo sapiens_hsa051610.31894945
92cAMP signaling pathway_Homo sapiens_hsa040240.30992126
93Sulfur metabolism_Homo sapiens_hsa009200.26727437
94Arginine biosynthesis_Homo sapiens_hsa002200.26515180
95Osteoclast differentiation_Homo sapiens_hsa043800.25008412
96Oxidative phosphorylation_Homo sapiens_hsa001900.24833302
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23628654
98Platelet activation_Homo sapiens_hsa046110.23418299
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.21934837
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21128641

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