LINGO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.29215287
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.86922563
3negative regulation of cell killing (GO:0031342)5.77630690
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.77630690
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.65934038
6synaptic vesicle maturation (GO:0016188)5.64854031
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.60150355
8positive regulation by symbiont of host defense response (GO:0052509)5.42718978
9modulation by symbiont of host defense response (GO:0052031)5.42718978
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.42718978
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.42718978
12positive regulation by organism of defense response of other organism involved in symbiotic interact5.42718978
13modulation by symbiont of host immune response (GO:0052553)5.42718978
14locomotory exploration behavior (GO:0035641)5.36106338
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.31724823
16vocalization behavior (GO:0071625)5.20927690
17synaptic vesicle exocytosis (GO:0016079)5.20129233
18neutrophil activation involved in immune response (GO:0002283)5.16629504
19regulation of synapse structural plasticity (GO:0051823)5.05557087
20detection of other organism (GO:0098543)5.01807014
21regulation of B cell receptor signaling pathway (GO:0050855)4.96803447
22antigen processing and presentation of endogenous antigen (GO:0019883)4.88172740
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86103122
24protein localization to synapse (GO:0035418)4.83931380
25detection of bacterium (GO:0016045)4.82088483
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.81843761
27macrophage activation involved in immune response (GO:0002281)4.78713199
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.77851666
29negative regulation of cytosolic calcium ion concentration (GO:0051481)4.69973471
30response to peptidoglycan (GO:0032494)4.69238232
31regulation of synaptic vesicle exocytosis (GO:2000300)4.63885214
32prepulse inhibition (GO:0060134)4.59706639
33regulation of glutamate receptor signaling pathway (GO:1900449)4.56867932
34cellular potassium ion homeostasis (GO:0030007)4.53953963
35regulation of gamma-delta T cell activation (GO:0046643)4.50416019
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.47325565
37ionotropic glutamate receptor signaling pathway (GO:0035235)4.46361217
38sodium ion export (GO:0071436)4.43765592
39positive regulation of B cell differentiation (GO:0045579)4.37540332
40cellular extravasation (GO:0045123)4.36729226
41regulation of long-term neuronal synaptic plasticity (GO:0048169)4.34205477
42synaptic vesicle docking involved in exocytosis (GO:0016081)4.30546037
43glutamate receptor signaling pathway (GO:0007215)4.29299165
44antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29258990
45leukocyte aggregation (GO:0070486)4.25911024
46positive regulation of synapse maturation (GO:0090129)4.24169372
47regulation of neuronal synaptic plasticity (GO:0048168)4.23754758
48neurotransmitter-gated ion channel clustering (GO:0072578)4.22078472
49detection of external biotic stimulus (GO:0098581)4.22003227
50neurotransmitter secretion (GO:0007269)4.21640463
51regulation of gamma-delta T cell differentiation (GO:0045586)4.19112474
52G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.18132959
53neuron-neuron synaptic transmission (GO:0007270)4.16517472
54B cell receptor signaling pathway (GO:0050853)4.15784449
55exploration behavior (GO:0035640)4.15119290
56synaptic transmission, glutamatergic (GO:0035249)4.14599523
57regulation of synaptic vesicle transport (GO:1902803)4.11635245
58neutrophil activation (GO:0042119)4.11614355
59respiratory burst (GO:0045730)4.08965621
60striatum development (GO:0021756)4.08708706
61glutamate secretion (GO:0014047)4.08304015
62regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.06809548
63negative regulation of interleukin-12 production (GO:0032695)4.06257600
64immunoglobulin mediated immune response (GO:0016064)4.04494718
65negative regulation of lymphocyte mediated immunity (GO:0002707)4.01493480
66regulation of mast cell degranulation (GO:0043304)4.00247356
67regulation of B cell differentiation (GO:0045577)3.99592691
68gamma-aminobutyric acid signaling pathway (GO:0007214)3.97612267
69neuronal action potential propagation (GO:0019227)3.93844849
70long-term memory (GO:0007616)3.91961596
71synaptic transmission, dopaminergic (GO:0001963)3.90176887
72detection of molecule of bacterial origin (GO:0032490)3.90039835
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89538451
74response to muramyl dipeptide (GO:0032495)3.88525387
75dendritic spine morphogenesis (GO:0060997)3.88311878
76regulation of excitatory postsynaptic membrane potential (GO:0060079)3.88222842
77positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.87814870
78regulation of interferon-beta biosynthetic process (GO:0045357)3.86883463
79negative regulation of erythrocyte differentiation (GO:0045647)3.86308804
80response to interleukin-15 (GO:0070672)3.83962604
81layer formation in cerebral cortex (GO:0021819)3.79954462
82response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.78878040
83response to host immune response (GO:0052572)3.78878040
84regulation of myeloid leukocyte mediated immunity (GO:0002886)3.76327378
85positive regulation of membrane potential (GO:0045838)3.73905876
86behavioral response to cocaine (GO:0048148)3.73770251
87regulation of dendritic spine morphogenesis (GO:0061001)3.73387998
88detection of biotic stimulus (GO:0009595)3.72831772
89myeloid cell activation involved in immune response (GO:0002275)3.72790241
90neuromuscular process controlling balance (GO:0050885)3.71466822
91positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.71230944
92positive thymic T cell selection (GO:0045059)3.70782219
93regulation of mast cell activation involved in immune response (GO:0033006)3.69417700
94granulocyte activation (GO:0036230)3.69408353
95regulation of postsynaptic membrane potential (GO:0060078)3.68826013
96negative regulation of leukocyte mediated immunity (GO:0002704)3.68001457
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.67846059
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.67023095
99negative thymic T cell selection (GO:0045060)3.64782285
100auditory behavior (GO:0031223)3.63225769
101regulation of leukocyte degranulation (GO:0043300)3.62921370
102microglial cell activation (GO:0001774)3.62793439
103membrane depolarization during action potential (GO:0086010)3.62136118
104positive regulation of mast cell activation (GO:0033005)3.62018575
105cell communication by electrical coupling (GO:0010644)3.61495038
106negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.61457133
107defense response to protozoan (GO:0042832)3.61170046
108negative regulation of T cell mediated immunity (GO:0002710)3.60723007
109macrophage activation (GO:0042116)3.60293914
110regulation of synaptic transmission, glutamatergic (GO:0051966)3.59551567
111membrane hyperpolarization (GO:0060081)3.57188497
112behavioral defense response (GO:0002209)3.56364083
113behavioral fear response (GO:0001662)3.56364083
114gamma-aminobutyric acid transport (GO:0015812)3.55950226
115neuron cell-cell adhesion (GO:0007158)3.54282576
116regulation of voltage-gated calcium channel activity (GO:1901385)3.53659241
117leukocyte migration involved in inflammatory response (GO:0002523)3.53262828
118mating behavior (GO:0007617)3.52356013
119positive regulation of synaptic transmission, GABAergic (GO:0032230)3.51686443
120germinal center formation (GO:0002467)3.51524024
121negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.51295796
122neutrophil mediated immunity (GO:0002446)3.50740704
123long-term synaptic potentiation (GO:0060291)3.50652254
124transmission of nerve impulse (GO:0019226)3.49562235
125regulation of synaptic plasticity (GO:0048167)3.49253039
126negative T cell selection (GO:0043383)3.48688978
127response to host (GO:0075136)3.46834398
128response to host defenses (GO:0052200)3.46834398
129response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.46834398
130response to auditory stimulus (GO:0010996)3.44678400
131positive regulation of neurotransmitter transport (GO:0051590)3.44298559
132response to histamine (GO:0034776)3.41886355
133neurotransmitter transport (GO:0006836)3.37950097
134dopamine receptor signaling pathway (GO:0007212)3.37854638
135activation of protein kinase A activity (GO:0034199)3.37714505
136potassium ion homeostasis (GO:0055075)3.37524136
137negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.37407609
138regulation of mast cell activation (GO:0033003)3.37168105
139positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.36571418
140adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.35484546
141regulation of neurotransmitter secretion (GO:0046928)3.33919832
142cerebellar Purkinje cell differentiation (GO:0021702)3.33589838
143cellular response to interleukin-15 (GO:0071350)3.32676253
144positive regulation of mast cell degranulation (GO:0043306)3.32381080
145positive regulation of mast cell activation involved in immune response (GO:0033008)3.32381080
146production of molecular mediator involved in inflammatory response (GO:0002532)3.31612809
147response to protozoan (GO:0001562)3.31435335
148membrane depolarization (GO:0051899)3.28893088
149regulation of neurotransmitter transport (GO:0051588)3.26583051
150synaptic vesicle endocytosis (GO:0048488)3.26149158
151response to amphetamine (GO:0001975)3.25801574
152leukocyte degranulation (GO:0043299)3.25504472
153fear response (GO:0042596)3.24856878
154response to pheromone (GO:0019236)3.24778990
155cellular sodium ion homeostasis (GO:0006883)3.24335275
156regulation of synapse maturation (GO:0090128)3.22065601
157regulation of regulated secretory pathway (GO:1903305)3.20203794
158T cell selection (GO:0045058)3.19977762
159learning (GO:0007612)3.19075978
160positive regulation of neurotransmitter secretion (GO:0001956)3.16072310
161positive T cell selection (GO:0043368)3.15729024
162negative regulation of phagocytosis (GO:0050765)3.15659343
163regulation of vesicle fusion (GO:0031338)3.15450901
164negative regulation of interleukin-6 production (GO:0032715)3.15437716
165visual learning (GO:0008542)3.15381023
166positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14742998
167innervation (GO:0060384)3.14372109
168regulation of neurotransmitter levels (GO:0001505)3.13394158
169myeloid leukocyte mediated immunity (GO:0002444)3.12640905
170neuromuscular process controlling posture (GO:0050884)3.12305973
171regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.12247709
172regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.12247709
173long term synaptic depression (GO:0060292)3.10359572
174B cell mediated immunity (GO:0019724)3.10055701
175negative regulation of T-helper cell differentiation (GO:0045623)3.09887817
176negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.09887817
177positive regulation of dendritic spine morphogenesis (GO:0061003)3.09800791
178positive regulation of granulocyte differentiation (GO:0030854)3.09619535
179regulation of female receptivity (GO:0045924)3.09527476
180regulation of glutamate secretion (GO:0014048)3.08422767
181G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08008563
182regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07720156
183regulation of neurotransmitter uptake (GO:0051580)3.07077872
184synapse assembly (GO:0007416)3.04988861
185thymic T cell selection (GO:0045061)2.99506498
186T cell migration (GO:0072678)2.98756317
187regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.97873489
188interferon-gamma-mediated signaling pathway (GO:0060333)2.96741298
189type I interferon signaling pathway (GO:0060337)2.95410761
190cellular response to type I interferon (GO:0071357)2.95410761
191regulation of T-helper 2 cell differentiation (GO:0045628)2.94902771
192response to type I interferon (GO:0034340)2.94265457
193tolerance induction (GO:0002507)2.92447443
194regulation of antigen processing and presentation (GO:0002577)2.92014650
195positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.84821558
196activated T cell proliferation (GO:0050798)2.83662082
197regulation of alpha-beta T cell proliferation (GO:0046640)2.82307166
198antigen processing and presentation via MHC class Ib (GO:0002475)2.82090627
199negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80662938
200positive regulation of regulated secretory pathway (GO:1903307)2.80361931

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.41035832
2EZH2_22144423_ChIP-Seq_EOC_Human5.27760024
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.05955448
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.72295591
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67487065
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.49073023
7VDR_21846776_ChIP-Seq_THP-1_Human3.48533790
8* RARB_27405468_Chip-Seq_BRAIN_Mouse3.26352900
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18137474
10GBX2_23144817_ChIP-Seq_PC3_Human3.17294595
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15392208
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09232120
13JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06992237
14MYC_22102868_ChIP-Seq_BL_Human2.98434478
15VDR_24763502_ChIP-Seq_THP-1_Human2.98170245
16DROSHA_22980978_ChIP-Seq_HELA_Human2.89964338
17SCL_19346495_ChIP-Seq_HPC-7_Human2.87424561
18REST_21632747_ChIP-Seq_MESCs_Mouse2.83687481
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.83029904
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.82745252
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79835773
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77459125
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77459125
24SPI1_23547873_ChIP-Seq_NB4_Human2.68025371
25RUNX_20019798_ChIP-Seq_JUKART_Human2.65059489
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.64364933
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64095653
28* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.61705260
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60786360
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59277212
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.55655649
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55263053
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.53671354
34MYB_21317192_ChIP-Seq_ERMYB_Mouse2.53380125
35MAF_26560356_Chip-Seq_TH1_Human2.51127576
36* SPI1_23127762_ChIP-Seq_K562_Human2.50519618
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46313462
38* EZH2_27294783_Chip-Seq_ESCs_Mouse2.45632905
39SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44978529
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.41687036
41* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40899500
42UTX_26944678_Chip-Seq_JUKART_Human2.37011459
43REST_18959480_ChIP-ChIP_MESCs_Mouse2.36619123
44MYB_26560356_Chip-Seq_TH2_Human2.34522516
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33606856
46RUNX1_22412390_ChIP-Seq_EML_Mouse2.33049079
47IKZF1_21737484_ChIP-ChIP_HCT116_Human2.31456033
48TCF7_22412390_ChIP-Seq_EML_Mouse2.31080704
49KDM2B_26808549_Chip-Seq_SUP-B15_Human2.30876524
50RNF2_27304074_Chip-Seq_ESCs_Mouse2.29670206
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.29420098
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.25345382
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.21945695
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20720790
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.17190238
56EED_16625203_ChIP-ChIP_MESCs_Mouse2.13513748
57BRD4_27068464_Chip-Seq_AML-cells_Mouse2.11353519
58MYB_26560356_Chip-Seq_TH1_Human2.09491489
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05124967
60KDM2B_26808549_Chip-Seq_DND41_Human2.04978041
61STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03069539
62* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.02253469
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98911124
64AR_21572438_ChIP-Seq_LNCaP_Human1.98572845
65MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.97584635
66MAF_26560356_Chip-Seq_TH2_Human1.94099517
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.86721653
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.83713846
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74066522
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.73896090
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.71412235
72GATA3_27048872_Chip-Seq_THYMUS_Human1.67942057
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67674804
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.64222989
75VDR_24787735_ChIP-Seq_THP-1_Human1.63778870
76LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62255375
77SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61161669
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60222970
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58817237
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58067598
81THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58009681
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55190935
83LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53912547
84* LXR_22292898_ChIP-Seq_THP-1_Human1.52278443
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51575848
86GATA1_19941826_ChIP-Seq_K562_Human1.51063788
87SMAD4_21799915_ChIP-Seq_A2780_Human1.49484921
88Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.49226134
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.44037783
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43326229
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42192637
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41167712
93RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38977845
94GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37672505
95DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37539510
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.36607522
97KDM2B_26808549_Chip-Seq_JURKAT_Human1.36353345
98P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36045224
99KDM2B_26808549_Chip-Seq_K562_Human1.34806901
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34606410
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34592737
102GATA1_22025678_ChIP-Seq_K562_Human1.34306031
103* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33907792
104PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33519288
105AR_19668381_ChIP-Seq_PC3_Human1.33138453
106GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32128824
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30337031
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29867401
109* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28686564
110ELF1_17652178_ChIP-ChIP_JURKAT_Human1.28201749
111* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27852355
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26754149
113SOX2_21211035_ChIP-Seq_LN229_Gbm1.25796502
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24595062
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24464668
116BCL6_27268052_Chip-Seq_Bcells_Human1.24407576
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24314832
118STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24199115
119WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23728167
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23031667
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22703352
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22604933
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22357750
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.22093298
125ZNF274_21170338_ChIP-Seq_K562_Hela1.21946102
126EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.21531441
127RING1B_27294783_Chip-Seq_NPCs_Mouse1.21269071
128PU_27001747_Chip-Seq_BMDM_Mouse1.20747598
129BCOR_27268052_Chip-Seq_Bcells_Human1.19091713
130* GATA3_26560356_Chip-Seq_TH2_Human1.18245820
131VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17517888
132* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16272241
133SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15309839
134TAF15_26573619_Chip-Seq_HEK293_Human1.14857483
135RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14670284
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14604772
137STAT3_23295773_ChIP-Seq_U87_Human1.14395030
138RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14338580
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13628033
140ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13504616
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12916914
142CIITA_25753668_ChIP-Seq_RAJI_Human1.12837481
143VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12631656
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12218805
145AR_25329375_ChIP-Seq_VCAP_Human1.11667977
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09755578
147* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09433492
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09270239
149* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08910565
150SMAD3_21741376_ChIP-Seq_HESCs_Human1.08005631
151NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07949094
152CTCF_27219007_Chip-Seq_Bcells_Human1.05998726
153CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04725374
154GATA2_19941826_ChIP-Seq_K562_Human1.03983495
155ELF1_20517297_ChIP-Seq_JURKAT_Human1.03648589
156NCOR1_26117541_ChIP-Seq_K562_Human1.03009314
157SMAD_19615063_ChIP-ChIP_OVARY_Human1.02907104
158P300_19829295_ChIP-Seq_ESCs_Human1.02747833
159YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01870975
160TCF4_23295773_ChIP-Seq_U87_Human1.01799843
161CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99696731
162CBX2_27304074_Chip-Seq_ESCs_Mouse0.99539111
163ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99421421
164PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98256538
165SA1_27219007_Chip-Seq_ERYTHROID_Human0.97542884
166SMAD4_21741376_ChIP-Seq_HESCs_Human0.97145961
167NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97040873
168TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96776350
169SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96726059
170ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96338637
171MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95514556
172BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95414942
173AHR_22903824_ChIP-Seq_MCF-7_Human0.94553469
174TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94075371
175P68_20966046_ChIP-Seq_HELA_Human0.93920340
176DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93179346
177PIAS1_25552417_ChIP-Seq_VCAP_Human0.92837872
178SPI1_20517297_ChIP-Seq_HL60_Human0.92455444
179ARNT_22903824_ChIP-Seq_MCF-7_Human0.92277744
180SMAD3_21741376_ChIP-Seq_ESCs_Human0.91764577
181RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.89560348
182ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88931216
183TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88857119
184OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87129831
185RNF2_27304074_Chip-Seq_NSC_Mouse0.86750378
186SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86469752
187CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86466114
188PRDM14_20953172_ChIP-Seq_ESCs_Human0.86152333
189* TET1_21490601_ChIP-Seq_MESCs_Mouse0.85978558
190RUNX2_22187159_ChIP-Seq_PCA_Human0.82633006
191NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82182650
192SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81926344
193* KLF4_19829295_ChIP-Seq_ESCs_Human0.80850056
194TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79656488
195UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78358322

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.31307361
2MP0002822_catalepsy5.12889407
3MP0003880_abnormal_central_pattern4.18601938
4MP0003635_abnormal_synaptic_transmissio4.14682547
5MP0003436_decreased_susceptibility_to4.08643055
6MP0003724_increased_susceptibility_to4.07946953
7MP0001835_abnormal_antigen_presentation3.75545256
8MP0003303_peritoneal_inflammation3.61234806
9MP0009745_abnormal_behavioral_response3.54863045
10MP0002063_abnormal_learning/memory/cond3.40601860
11MP0004270_analgesia3.30736489
12MP0002419_abnormal_innate_immunity3.16459024
13MP0002064_seizures3.09340587
14MP0009046_muscle_twitch3.07291484
15MP0001800_abnormal_humoral_immune3.00543376
16MP0000685_abnormal_immune_system2.87142481
17MP0005671_abnormal_response_to2.86956477
18MP0005387_immune_system_phenotype2.86854184
19MP0001790_abnormal_immune_system2.86854184
20MP0005025_abnormal_response_to2.86339875
21MP0005000_abnormal_immune_tolerance2.78915888
22MP0002572_abnormal_emotion/affect_behav2.71188641
23MP0001486_abnormal_startle_reflex2.68725896
24MP0005423_abnormal_somatic_nervous2.67445539
25MP0002420_abnormal_adaptive_immunity2.64951723
26MP0002272_abnormal_nervous_system2.64902239
27MP0002723_abnormal_immune_serum2.64496261
28MP0001819_abnormal_immune_cell2.61939683
29MP0002452_abnormal_antigen_presenting2.59109104
30MP0003763_abnormal_thymus_physiology2.47804967
31MP0001968_abnormal_touch/_nociception2.47720296
32MP0009785_altered_susceptibility_to2.47631405
33MP0009278_abnormal_bone_marrow2.46503760
34MP0005551_abnormal_eye_electrophysiolog2.36034057
35MP0008260_abnormal_autophagy2.35080829
36MP0002396_abnormal_hematopoietic_system2.34075629
37MP0002734_abnormal_mechanical_nocicepti2.30771548
38MP0003300_gastrointestinal_ulcer2.30154062
39MP0005464_abnormal_platelet_physiology2.28074381
40MP0002148_abnormal_hypersensitivity_rea2.19416943
41MP0003191_abnormal_cellular_cholesterol2.18760071
42MP0003172_abnormal_lysosome_physiology2.17413099
43MP0006082_CNS_inflammation2.15336786
44MP0002398_abnormal_bone_marrow2.13538618
45MP0002405_respiratory_system_inflammati2.09481291
46MP0008569_lethality_at_weaning2.09050826
47MP0001501_abnormal_sleep_pattern2.06583878
48MP0001984_abnormal_olfaction2.06495866
49MP0000716_abnormal_immune_system2.03311129
50MP0002909_abnormal_adrenal_gland2.01146183
51MP0001533_abnormal_skeleton_physiology1.87993175
52MP0005397_hematopoietic_system_phenotyp1.85928805
53MP0001545_abnormal_hematopoietic_system1.85928805
54MP0002067_abnormal_sensory_capabilities1.85917879
55MP0001529_abnormal_vocalization1.82508446
56MP0001440_abnormal_grooming_behavior1.82472630
57MP0002132_abnormal_respiratory_system1.81279137
58MP0000465_gastrointestinal_hemorrhage1.80114129
59MP0001502_abnormal_circadian_rhythm1.79835527
60MP0000689_abnormal_spleen_morphology1.78719042
61MP0004924_abnormal_behavior1.76756667
62MP0005386_behavior/neurological_phenoty1.76756667
63MP0002736_abnormal_nociception_after1.76383453
64MP0002722_abnormal_immune_system1.74020486
65MP0010155_abnormal_intestine_physiology1.73831878
66MP0002184_abnormal_innervation1.71923295
67MP0005310_abnormal_salivary_gland1.71432612
68MP0001970_abnormal_pain_threshold1.70982288
69MP0004947_skin_inflammation1.70813162
70MP0001845_abnormal_inflammatory_respons1.69937424
71MP0005451_abnormal_body_composition1.67827925
72MP0009333_abnormal_splenocyte_physiolog1.66871858
73MP0004811_abnormal_neuron_physiology1.64134032
74MP0002557_abnormal_social/conspecific_i1.63919001
75MP0002090_abnormal_vision1.62555256
76MP0002429_abnormal_blood_cell1.62275437
77MP0002733_abnormal_thermal_nociception1.60298919
78MP0000703_abnormal_thymus_morphology1.58800657
79MP0003866_abnormal_defecation1.57740350
80MP0003828_pulmonary_edema1.56075447
81MP0003879_abnormal_hair_cell1.54517573
82MP0000751_myopathy1.52600005
83MP0003329_amyloid_beta_deposits1.51512827
84MP0002735_abnormal_chemical_nociception1.49371197
85MP0004381_abnormal_hair_follicle1.47964518
86MP0004885_abnormal_endolymph1.47417543
87MP0003183_abnormal_peptide_metabolism1.45484727
88MP0005646_abnormal_pituitary_gland1.44914354
89MP0002882_abnormal_neuron_morphology1.44828732
90MP0006072_abnormal_retinal_apoptosis1.43180897
91MP0009780_abnormal_chondrocyte_physiolo1.40413737
92MP0000955_abnormal_spinal_cord1.40001316
93MP0000778_abnormal_nervous_system1.38369609
94MP0008469_abnormal_protein_level1.37934400
95MP0004145_abnormal_muscle_electrophysio1.37926930
96MP0001851_eye_inflammation1.36065595
97MP0002066_abnormal_motor_capabilities/c1.35991729
98MP0003633_abnormal_nervous_system1.33658082
99MP0004233_abnormal_muscle_weight1.31238479
100MP0009764_decreased_sensitivity_to1.30013324
101MP0004858_abnormal_nervous_system1.28737993
102MP0004142_abnormal_muscle_tone1.28418027
103MP0001188_hyperpigmentation1.22684028
104MP0005058_abnormal_lysosome_morphology1.20020226
105MP0004215_abnormal_myocardial_fiber1.19652277
106MP0002229_neurodegeneration1.18743541
107MP0004883_abnormal_blood_vessel1.18060656
108MP0004510_myositis1.17322235
109MP0002998_abnormal_bone_remodeling1.16600790
110MP0002166_altered_tumor_susceptibility1.15406640
111MP0004808_abnormal_hematopoietic_stem1.15189999
112MP0005253_abnormal_eye_physiology1.14755322
113MP0008961_abnormal_basal_metabolism1.14272694
114MP0000013_abnormal_adipose_tissue1.12114894
115MP0005075_abnormal_melanosome_morpholog1.11394327
116MP0004085_abnormal_heartbeat1.11376172
117MP0003137_abnormal_impulse_conducting1.09393815
118MP0003631_nervous_system_phenotype1.08127965
119MP0008872_abnormal_physiological_respon1.06637145
120MP0002277_abnormal_respiratory_mucosa1.05569799
121MP0002638_abnormal_pupillary_reflex1.04652874
122MP0002152_abnormal_brain_morphology1.04505484
123MP0001873_stomach_inflammation1.02674183
124MP0003075_altered_response_to1.00318661
125MP0000858_altered_metastatic_potential0.99804460
126MP0001853_heart_inflammation0.97463701
127MP0002069_abnormal_eating/drinking_beha0.96508809
128MP0001986_abnormal_taste_sensitivity0.95879165
129MP0005394_taste/olfaction_phenotype0.95504097
130MP0005499_abnormal_olfactory_system0.95504097
131MP0001905_abnormal_dopamine_level0.95403655
132MP0008874_decreased_physiological_sensi0.95080184
133MP0005409_darkened_coat_color0.93035635
134MP0002752_abnormal_somatic_nervous0.92160869
135MP0003787_abnormal_imprinting0.91865782
136MP0001177_atelectasis0.91567443
137MP0006276_abnormal_autonomic_nervous0.91384782
138MP0003656_abnormal_erythrocyte_physiolo0.89107138
139MP0001663_abnormal_digestive_system0.88098754
140MP0000631_abnormal_neuroendocrine_gland0.86158799
141MP0005166_decreased_susceptibility_to0.85124347
142MP0005164_abnormal_response_to0.83059322
143MP0003634_abnormal_glial_cell0.82831581
144MP0000015_abnormal_ear_pigmentation0.82544383
145MP0005535_abnormal_body_temperature0.80924339
146MP0008004_abnormal_stomach_pH0.80836395
147MP0005195_abnormal_posterior_eye0.80641666
148MP0004036_abnormal_muscle_relaxation0.78690268
149MP0005645_abnormal_hypothalamus_physiol0.78448082
150MP0009763_increased_sensitivity_to0.77301374
151MP0000490_abnormal_crypts_of0.77288823
152MP0000343_altered_response_to0.76752201
153MP0002009_preneoplasia0.74593969
154MP0009765_abnormal_xenobiotic_induced0.74374801
155MP0002006_tumorigenesis0.72838324
156MP0002837_dystrophic_cardiac_calcinosis0.72585299
157MP0005620_abnormal_muscle_contractility0.71959920
158MP0000920_abnormal_myelination0.71606709
159MP0003690_abnormal_glial_cell0.71400571
160MP0005167_abnormal_blood-brain_barrier0.71345957
161MP0003632_abnormal_nervous_system0.71320834
162MP0003646_muscle_fatigue0.70912842
163MP0003283_abnormal_digestive_organ0.69927507
164MP0003045_fibrosis0.69807040
165MP0005390_skeleton_phenotype0.66709286
166MP0010386_abnormal_urinary_bladder0.66554228
167MP0006292_abnormal_olfactory_placode0.64610674
168MP0002138_abnormal_hepatobiliary_system0.64576181
169MP0004742_abnormal_vestibular_system0.64305158
170MP0002019_abnormal_tumor_incidence0.64153040
171MP0002933_joint_inflammation0.63702463
172MP0002234_abnormal_pharynx_morphology0.62729698
173MP0001963_abnormal_hearing_physiology0.62448584
174MP0009840_abnormal_foam_cell0.62145260
175MP0004130_abnormal_muscle_cell0.60468638
176MP0003448_altered_tumor_morphology0.60096153
177MP0000604_amyloidosis0.59239579
178MP0004043_abnormal_pH_regulation0.58991646
179MP0000747_muscle_weakness0.58579062
180MP0000249_abnormal_blood_vessel0.57367801
181MP0003221_abnormal_cardiomyocyte_apopto0.57202842
182MP0003795_abnormal_bone_structure0.56915992
183MP0005076_abnormal_cell_differentiation0.56504854
184MP0004484_altered_response_of0.54986346
185MP0000569_abnormal_digit_pigmentation0.54762582
186MP0010234_abnormal_vibrissa_follicle0.53659067
187MP0002332_abnormal_exercise_endurance0.53272242
188MP0002089_abnormal_postnatal_growth/wei0.52465954
189MP0000749_muscle_degeneration0.52046968
190MP0002693_abnormal_pancreas_physiology0.50874948
191MP0003091_abnormal_cell_migration0.46863021
192MP0005381_digestive/alimentary_phenotyp0.46465854

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.63260174
2Focal motor seizures (HP:0011153)7.15597728
3Eczematoid dermatitis (HP:0000976)6.56603563
4Recurrent bacterial skin infections (HP:0005406)6.05002779
5Recurrent abscess formation (HP:0002722)6.00497317
6Myositis (HP:0100614)5.43144642
7Focal seizures (HP:0007359)5.27657231
8Stomatitis (HP:0010280)5.05038772
9Visual hallucinations (HP:0002367)5.02922878
10Abnormality of macrophages (HP:0004311)4.96386797
11Orchitis (HP:0100796)4.88126405
12Elevated erythrocyte sedimentation rate (HP:0003565)4.74503976
13Recurrent gram-negative bacterial infections (HP:0005420)4.70920960
14Epileptic encephalopathy (HP:0200134)4.64438192
15Mediastinal lymphadenopathy (HP:0100721)4.57155411
16Febrile seizures (HP:0002373)4.52396194
17Optic neuritis (HP:0100653)4.51517912
18Retrobulbar optic neuritis (HP:0100654)4.51517912
19Recurrent fungal infections (HP:0002841)4.45578247
20Action tremor (HP:0002345)4.43369677
21Progressive cerebellar ataxia (HP:0002073)4.38896214
22Congenital stationary night blindness (HP:0007642)4.29722976
23Meningitis (HP:0001287)4.29003649
24Abnormal delayed hypersensitivity skin test (HP:0002963)4.25300953
25Chronic obstructive pulmonary disease (HP:0006510)4.23578988
26Obstructive lung disease (HP:0006536)4.23578988
27Central scotoma (HP:0000603)4.20506862
28Absence seizures (HP:0002121)4.12630540
29Recurrent skin infections (HP:0001581)4.11963769
30Recurrent cutaneous fungal infections (HP:0011370)4.06299928
31Chronic mucocutaneous candidiasis (HP:0002728)4.06299928
32Dysdiadochokinesis (HP:0002075)3.91922039
33Hypochromic microcytic anemia (HP:0004840)3.79993007
34Cellulitis (HP:0100658)3.76729917
35Dialeptic seizures (HP:0011146)3.72521815
36Gastrointestinal infarctions (HP:0005244)3.70816020
37Encephalitis (HP:0002383)3.65644928
38Generalized tonic-clonic seizures (HP:0002069)3.64365395
39Atonic seizures (HP:0010819)3.62817656
40Increased IgE level (HP:0003212)3.61871947
41Panhypogammaglobulinemia (HP:0003139)3.61767283
42Depression (HP:0000716)3.53423794
43Gaze-evoked nystagmus (HP:0000640)3.52311069
44Urticaria (HP:0001025)3.49316033
45Spontaneous hematomas (HP:0007420)3.47411266
46Prolonged bleeding time (HP:0003010)3.42181152
47Gingivitis (HP:0000230)3.39896147
48Anxiety (HP:0000739)3.39415087
49Broad-based gait (HP:0002136)3.38090757
50Poor eye contact (HP:0000817)3.37637959
51Vasculitis (HP:0002633)3.37084043
52Dysmetric saccades (HP:0000641)3.29580298
53Ankle clonus (HP:0011448)3.28094892
54Hypochromic anemia (HP:0001931)3.25176772
55Agammaglobulinemia (HP:0004432)3.23882369
56Recurrent viral infections (HP:0004429)3.23304905
57Dysmetria (HP:0001310)3.22781166
58Keratoconjunctivitis sicca (HP:0001097)3.20009999
59Scanning speech (HP:0002168)3.17223992
60Annular pancreas (HP:0001734)3.16581422
61Inflammation of the large intestine (HP:0002037)3.13079613
62Abnormality of macular pigmentation (HP:0008002)3.12467567
63Chest pain (HP:0100749)3.10314832
64Torticollis (HP:0000473)3.10228551
65Abnormal social behavior (HP:0012433)3.09778983
66Impaired social interactions (HP:0000735)3.09778983
67Gastrointestinal inflammation (HP:0004386)3.07047720
68Impaired vibration sensation in the lower limbs (HP:0002166)3.07041564
69Abnormality of the lower motor neuron (HP:0002366)3.06531840
70Postural instability (HP:0002172)3.01245666
71Episodic fever (HP:0001954)2.98476928
72Scotoma (HP:0000575)2.97896284
73Keratoconjunctivitis (HP:0001096)2.95600105
74Ventricular fibrillation (HP:0001663)2.94262050
75Supranuclear gaze palsy (HP:0000605)2.93795916
76Truncal ataxia (HP:0002078)2.93008808
77Colitis (HP:0002583)2.90564495
78Pustule (HP:0200039)2.89156011
79Genetic anticipation (HP:0003743)2.87947197
80Prolonged QT interval (HP:0001657)2.87941947
81Urinary bladder sphincter dysfunction (HP:0002839)2.86172155
82Mutism (HP:0002300)2.84095346
83Hemoptysis (HP:0002105)2.83455760
84Osteomyelitis (HP:0002754)2.80855075
85Pulmonary infiltrates (HP:0002113)2.77356765
86Hemiparesis (HP:0001269)2.76829651
87Impaired smooth pursuit (HP:0007772)2.75374928
88Epistaxis (HP:0000421)2.75264714
89Granulocytopenia (HP:0001913)2.74454530
90Focal dystonia (HP:0004373)2.73466154
91Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.72473712
92Hemiplegia (HP:0002301)2.71628463
93Leukocytosis (HP:0001974)2.71335584
94T lymphocytopenia (HP:0005403)2.70571490
95Abnormality of T cells (HP:0002843)2.66311485
96Abnormal EKG (HP:0003115)2.63847549
97Intention tremor (HP:0002080)2.55829897
98Gingival bleeding (HP:0000225)2.55187907
99Abnormality of T cell number (HP:0011839)2.54918619
100Resting tremor (HP:0002322)2.54304528
101Craniofacial dystonia (HP:0012179)2.53981974
102Arterial thrombosis (HP:0004420)2.52884974
103Lymphopenia (HP:0001888)2.52249457
104IgM deficiency (HP:0002850)2.51751190
105Sepsis (HP:0100806)2.51065825
106Stereotypic behavior (HP:0000733)2.47835460
107Abnormality of T cell physiology (HP:0011840)2.47643662
108Amblyopia (HP:0000646)2.47120699
109Viral hepatitis (HP:0006562)2.46446889
110Abnormal eating behavior (HP:0100738)2.46044244
111Pointed chin (HP:0000307)2.44909365
112Petechiae (HP:0000967)2.44526920
113Microcytic anemia (HP:0001935)2.44020734
114Abnormality of ocular smooth pursuit (HP:0000617)2.41902456
115Anorexia (HP:0002039)2.41881306
116Pulmonary embolism (HP:0002204)2.41247650
117Urinary urgency (HP:0000012)2.38962514
118Bradykinesia (HP:0002067)2.38127876
119Spastic gait (HP:0002064)2.37370496
120Amyloidosis (HP:0011034)2.33520831
121Exercise-induced myalgia (HP:0003738)2.31442358
122Abnormality of cells of the lymphoid lineage (HP:0012140)2.30132359
123Peritonitis (HP:0002586)2.29500881
124Abnormal rod and cone electroretinograms (HP:0008323)2.24476809
125Drooling (HP:0002307)2.22009882
126Excessive salivation (HP:0003781)2.22009882
127Increased cerebral lipofuscin (HP:0011813)2.21678966
128Severe visual impairment (HP:0001141)2.20626279
129Epileptiform EEG discharges (HP:0011182)2.20145593
130Verrucae (HP:0200043)2.19904442
131Papilloma (HP:0012740)2.19904442
132Status epilepticus (HP:0002133)2.19684072
133Incomplete penetrance (HP:0003829)2.18247083
134Bony spicule pigmentary retinopathy (HP:0007737)2.17794960
135Abnormality of the peritoneum (HP:0002585)2.17327205
136Abnormality of the pleura (HP:0002103)2.13667567
137Hyperventilation (HP:0002883)2.11175823
138Impaired vibratory sensation (HP:0002495)2.10888009
139Slow saccadic eye movements (HP:0000514)2.10792220
140Gastrointestinal stroma tumor (HP:0100723)2.09678031
141Fetal akinesia sequence (HP:0001989)2.08889625
142Abnormality of the fingertips (HP:0001211)2.08880321
143EEG with generalized epileptiform discharges (HP:0011198)2.08752283
144Bundle branch block (HP:0011710)2.06510179
145Hepatosplenomegaly (HP:0001433)2.06285995
146Recurrent sinusitis (HP:0011108)2.04673995
147Skin ulcer (HP:0200042)2.03971257
148Autoimmune thrombocytopenia (HP:0001973)2.03906336
149Abnormality of the heme biosynthetic pathway (HP:0010472)2.02820580
150Loss of speech (HP:0002371)2.02045249
151Lower limb amyotrophy (HP:0007210)2.02017711
152Primary atrial arrhythmia (HP:0001692)2.01953625
153Atrial fibrillation (HP:0005110)2.01860122
154Ankyloglossia (HP:0010296)1.99463383
155Papilledema (HP:0001085)1.99058444
156Chronic otitis media (HP:0000389)1.98698540
157Fatigue (HP:0012378)1.97824573
158Hypergammaglobulinemia (HP:0010702)1.97062330
159Skin rash (HP:0000988)1.94570240
160Increased IgM level (HP:0003496)1.94390394
161Abnormality of saccadic eye movements (HP:0000570)1.94295403
162Recurrent pneumonia (HP:0006532)1.94083775
163Clonus (HP:0002169)1.94068176
164Gangrene (HP:0100758)1.93416137
165Increased serum ferritin (HP:0003281)1.93111170
166Eosinophilia (HP:0001880)1.92833505
167Lower limb muscle weakness (HP:0007340)1.92167466
168Insomnia (HP:0100785)1.91430555
169Premature loss of primary teeth (HP:0006323)1.90938918
170Abnormality of binocular vision (HP:0011514)1.90847648
171Diplopia (HP:0000651)1.90847648
172Acute hepatic failure (HP:0006554)1.90062250
173Abnormality of iron homeostasis (HP:0011031)1.89973644
174Glomerulopathy (HP:0100820)1.89329536
175Syncope (HP:0001279)1.88713930
176Increased neuronal autofluorescent lipopigment (HP:0002074)1.88641007
177Megalencephaly (HP:0001355)1.88141770
178Abnormality of the endocardium (HP:0004306)1.88081307
179Decreased central vision (HP:0007663)1.87590373
180Supraventricular tachycardia (HP:0004755)1.87287606
181Recurrent bronchitis (HP:0002837)1.86879943
182Progressive inability to walk (HP:0002505)1.86725584
183Hypsarrhythmia (HP:0002521)1.86365665
184Recurrent lower respiratory tract infections (HP:0002783)1.85476725
185Purpura (HP:0000979)1.83782913
186Vertigo (HP:0002321)1.83228717
187Restrictive lung disease (HP:0002091)1.82536177
188Generalized myoclonic seizures (HP:0002123)1.82268316
189Supraventricular arrhythmia (HP:0005115)1.80097813
190Absent speech (HP:0001344)1.79626627
191Gait ataxia (HP:0002066)1.76516636
192Pheochromocytoma (HP:0002666)1.75027891
193Neurofibrillary tangles (HP:0002185)1.74649713
194Limb dystonia (HP:0002451)1.74251504
195Lower limb asymmetry (HP:0100559)1.73416842
196Upper limb amyotrophy (HP:0009129)1.72688204
197Distal upper limb amyotrophy (HP:0007149)1.72688204
198Tetraplegia (HP:0002445)1.71179008
199Cerebral inclusion bodies (HP:0100314)1.71123194
200Rigidity (HP:0002063)1.68285151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.04568819
2NTRK33.98582695
3MAP4K13.96066115
4MAP3K93.55815784
5ERN13.27571789
6MAP2K33.13005604
7IRAK43.01815514
8BLK3.00364624
9MINK12.57924732
10MARK12.50717136
11GRK62.50199642
12DAPK22.46112973
13MAP3K42.44270196
14PAK62.35983364
15KSR22.35805187
16TYK22.34849945
17CAMKK12.22521745
18PRKD32.19877547
19CSK2.07426375
20BTK2.04168073
21RIPK41.99905486
22NTRK21.99112666
23SYK1.85623943
24KSR11.81857910
25ZAP701.81479254
26MAP2K71.77654901
27PINK11.76313043
28MAP3K131.76234186
29MAP3K111.69300109
30HCK1.68844884
31JAK31.64427998
32STK381.61971142
33TAOK31.60568060
34IKBKE1.59807327
35MAP3K141.58637856
36CAMKK21.58378767
37KIT1.57296104
38PRPF4B1.57206825
39CDK51.57117630
40NTRK11.53412816
41ARAF1.52578355
42TXK1.50034683
43TNIK1.50021552
44EPHB11.45047638
45SIK21.43697376
46FES1.42569309
47MAP3K31.41352266
48DAPK11.39487727
49MAP2K41.37588352
50NEK11.35212892
51FGR1.34219666
52CSF1R1.33802210
53LYN1.33642656
54TBK11.32935729
55PHKG11.31703381
56PHKG21.31703381
57ITK1.25911638
58JAK21.23873909
59LCK1.20658179
60TAOK11.19526153
61PRKCG1.16868404
62RIPK11.16511322
63TRIB31.12950398
64SGK4941.09556048
65SGK2231.09556048
66TYRO31.09014199
67JAK11.07047725
68TEC1.06939641
69SMG11.05731083
70RAF11.03324530
71MARK21.03083554
72IRAK21.02546197
73CAMK10.99612293
74SIK30.97753316
75IKBKB0.94603897
76PLK20.94282512
77CDK180.93748451
78MARK30.93597322
79IRAK10.93583345
80CAMK2A0.93289671
81GRK50.93140401
82CDK150.93102914
83SGK20.92923310
84MAP3K20.92246435
85MAPK130.92204887
86MAPK120.91311557
87STK110.88806105
88CDK140.88204882
89CAMK2B0.86559011
90PRKCH0.86379779
91SGK30.85867057
92STK100.85840105
93UHMK10.84098025
94SGK10.84021731
95TESK20.81811554
96CDK11A0.81543751
97DYRK1A0.81328959
98PTK60.77419484
99TGFBR20.77152638
100LMTK20.75464905
101MATK0.74198648
102BMPR20.73618960
103TNK20.71862545
104ALK0.71518130
105CDK120.71340490
106MAP3K70.69335066
107PDK10.68089595
108RET0.67270767
109PIM10.67059905
110YES10.65545366
111LRRK20.64916112
112CAMK2D0.64351967
113RPS6KA30.63467499
114MAP3K60.62900035
115CAMK40.61932972
116PAK30.61927156
117PTK2B0.61740785
118HIPK20.61461919
119PRKCQ0.61438589
120DMPK0.61313769
121PDPK10.60763232
122NEK60.60309783
123CDK190.58706629
124PRKCZ0.56602335
125MAP3K120.56462975
126DYRK1B0.56436859
127MAPK70.55142362
128WNK10.54619699
129CASK0.54568536
130CAMK1D0.54251743
131NME10.53381249
132MAP3K10.51799233
133FYN0.51598069
134MAPK100.51443634
135CAMK2G0.50711778
136PIK3CG0.50280376
137GRK70.50204016
138RPS6KL10.49628152
139RPS6KC10.49628152
140MAP2K60.49607054
141CDC42BPA0.48500276
142FGFR30.48180614
143PNCK0.47351432
144MAP3K100.46530803
145CDK40.45804570
146SCYL20.45344122
147PRKCE0.44155106
148MAP2K10.42967032
149BRAF0.42614821
150CSNK1G20.42411380
151RPS6KA60.41919399
152PRKCB0.41033136
153LATS20.40164256
154PRKACA0.37671100
155DAPK30.36976482
156TAOK20.36327304
157PRKD20.35468003
158ICK0.35445829
159PRKCA0.34839500
160MAPK80.33782909
161FGFR40.33044354
162PRKACG0.32874194
163BRSK10.32312178
164MAP3K50.32151854
165SIK10.30734630
166NLK0.30233545
167MAPK110.28352519
168PRKD10.28014346

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.83082443
2GABAergic synapse_Homo sapiens_hsa047273.06087431
3Synaptic vesicle cycle_Homo sapiens_hsa047213.05899160
4Olfactory transduction_Homo sapiens_hsa047403.05819432
5Leishmaniasis_Homo sapiens_hsa051403.02199549
6Morphine addiction_Homo sapiens_hsa050322.92740274
7Osteoclast differentiation_Homo sapiens_hsa043802.89112320
8Circadian entrainment_Homo sapiens_hsa047132.89017645
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81453466
10Staphylococcus aureus infection_Homo sapiens_hsa051502.63993350
11B cell receptor signaling pathway_Homo sapiens_hsa046622.60275360
12Glutamatergic synapse_Homo sapiens_hsa047242.59778750
13Long-term potentiation_Homo sapiens_hsa047202.48311650
14Allograft rejection_Homo sapiens_hsa053302.40587445
15Primary immunodeficiency_Homo sapiens_hsa053402.38827626
16Amphetamine addiction_Homo sapiens_hsa050312.35210101
17Graft-versus-host disease_Homo sapiens_hsa053322.31970800
18Autoimmune thyroid disease_Homo sapiens_hsa053202.21130591
19Dopaminergic synapse_Homo sapiens_hsa047282.20131495
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.18013863
21Salivary secretion_Homo sapiens_hsa049702.17077992
22Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.14530417
23Tuberculosis_Homo sapiens_hsa051522.13642963
24Cholinergic synapse_Homo sapiens_hsa047252.11639570
25Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.04875186
26Acute myeloid leukemia_Homo sapiens_hsa052211.97102702
27Phototransduction_Homo sapiens_hsa047441.95726545
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93701633
29Insulin secretion_Homo sapiens_hsa049111.92187122
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91457766
31Renin secretion_Homo sapiens_hsa049241.86393453
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84904413
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.83342790
34Oxytocin signaling pathway_Homo sapiens_hsa049211.82952403
35Cocaine addiction_Homo sapiens_hsa050301.82882706
36Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.79606511
37Gastric acid secretion_Homo sapiens_hsa049711.73825191
38NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72377921
39Calcium signaling pathway_Homo sapiens_hsa040201.68920206
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.65481682
41Serotonergic synapse_Homo sapiens_hsa047261.62247704
42Long-term depression_Homo sapiens_hsa047301.62124155
43T cell receptor signaling pathway_Homo sapiens_hsa046601.61996548
44Taste transduction_Homo sapiens_hsa047421.61621440
45Asthma_Homo sapiens_hsa053101.60808322
46Antigen processing and presentation_Homo sapiens_hsa046121.60270802
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.59578614
48Malaria_Homo sapiens_hsa051441.59155739
49Hematopoietic cell lineage_Homo sapiens_hsa046401.58402471
50Toxoplasmosis_Homo sapiens_hsa051451.54476705
51Measles_Homo sapiens_hsa051621.54250706
52Other glycan degradation_Homo sapiens_hsa005111.49954813
53Influenza A_Homo sapiens_hsa051641.43763373
54Viral myocarditis_Homo sapiens_hsa054161.41868828
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39454697
56Gap junction_Homo sapiens_hsa045401.39040883
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37305594
58cAMP signaling pathway_Homo sapiens_hsa040241.35973546
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35620730
60GnRH signaling pathway_Homo sapiens_hsa049121.34633313
61Herpes simplex infection_Homo sapiens_hsa051681.33893728
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28336303
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.27800809
64Phagosome_Homo sapiens_hsa041451.24882664
65Cardiac muscle contraction_Homo sapiens_hsa042601.24862376
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24434288
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22061375
68Legionellosis_Homo sapiens_hsa051341.20257615
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19358923
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18928779
71TNF signaling pathway_Homo sapiens_hsa046681.16392170
72Leukocyte transendothelial migration_Homo sapiens_hsa046701.14715637
73Type II diabetes mellitus_Homo sapiens_hsa049301.13340882
74Hepatitis B_Homo sapiens_hsa051611.12010258
75Phosphatidylinositol signaling system_Homo sapiens_hsa040701.11009316
76Dilated cardiomyopathy_Homo sapiens_hsa054141.08425127
77Circadian rhythm_Homo sapiens_hsa047101.07753177
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05329872
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05183532
80Vascular smooth muscle contraction_Homo sapiens_hsa042701.02228754
81Chronic myeloid leukemia_Homo sapiens_hsa052200.99194095
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99107382
83Rheumatoid arthritis_Homo sapiens_hsa053230.98187812
84Estrogen signaling pathway_Homo sapiens_hsa049150.97478746
85Glioma_Homo sapiens_hsa052140.95273092
86Pancreatic cancer_Homo sapiens_hsa052120.94966348
87Collecting duct acid secretion_Homo sapiens_hsa049660.93917182
88Nitrogen metabolism_Homo sapiens_hsa009100.93816371
89Hepatitis C_Homo sapiens_hsa051600.93448361
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.90873025
91Pertussis_Homo sapiens_hsa051330.90618052
92Notch signaling pathway_Homo sapiens_hsa043300.89123774
93Apoptosis_Homo sapiens_hsa042100.87314066
94Pancreatic secretion_Homo sapiens_hsa049720.85293800
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.83836518
96Melanogenesis_Homo sapiens_hsa049160.81963716
97Prolactin signaling pathway_Homo sapiens_hsa049170.80852243
98Axon guidance_Homo sapiens_hsa043600.80784949
99Shigellosis_Homo sapiens_hsa051310.80731388
100Epstein-Barr virus infection_Homo sapiens_hsa051690.80293356
101Lysosome_Homo sapiens_hsa041420.78743388
102Oocyte meiosis_Homo sapiens_hsa041140.78058780
103ErbB signaling pathway_Homo sapiens_hsa040120.77347117
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.76812623
105Salmonella infection_Homo sapiens_hsa051320.75631932
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73482577
107Thyroid hormone synthesis_Homo sapiens_hsa049180.73046695
108Viral carcinogenesis_Homo sapiens_hsa052030.72259990
109Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70658506
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69427428
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68462867
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67861276
113FoxO signaling pathway_Homo sapiens_hsa040680.66788911
114MAPK signaling pathway_Homo sapiens_hsa040100.66740743
115Alcoholism_Homo sapiens_hsa050340.66605160
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66026947
117Choline metabolism in cancer_Homo sapiens_hsa052310.65485484
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64931783
119mTOR signaling pathway_Homo sapiens_hsa041500.64921845
120HTLV-I infection_Homo sapiens_hsa051660.63575094
121Regulation of autophagy_Homo sapiens_hsa041400.61634322
122Adipocytokine signaling pathway_Homo sapiens_hsa049200.60433693
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59225441
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58691843
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57945938
126Glucagon signaling pathway_Homo sapiens_hsa049220.57046927
127Bile secretion_Homo sapiens_hsa049760.56515126
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55688590
129Dorso-ventral axis formation_Homo sapiens_hsa043200.55007063
130VEGF signaling pathway_Homo sapiens_hsa043700.54609847
131Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54378944
132Rap1 signaling pathway_Homo sapiens_hsa040150.54101890
133Colorectal cancer_Homo sapiens_hsa052100.53308837
134Inositol phosphate metabolism_Homo sapiens_hsa005620.52181585
135Vibrio cholerae infection_Homo sapiens_hsa051100.52083403
136Non-small cell lung cancer_Homo sapiens_hsa052230.50864304
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50622768
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.49318852
139Systemic lupus erythematosus_Homo sapiens_hsa053220.47192555
140Ras signaling pathway_Homo sapiens_hsa040140.46983817
141Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46854704
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46168583
143Neurotrophin signaling pathway_Homo sapiens_hsa047220.46156366
144Insulin resistance_Homo sapiens_hsa049310.45730939
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44315997
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43126652
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42904757
148Amoebiasis_Homo sapiens_hsa051460.41187194
149Endocytosis_Homo sapiens_hsa041440.40288067
150Sphingolipid signaling pathway_Homo sapiens_hsa040710.40205151
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.38420531
152Renal cell carcinoma_Homo sapiens_hsa052110.36121426
153Chemokine signaling pathway_Homo sapiens_hsa040620.35045345
154Endometrial cancer_Homo sapiens_hsa052130.34582356
155Insulin signaling pathway_Homo sapiens_hsa049100.34265378
156Type I diabetes mellitus_Homo sapiens_hsa049400.32186766
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32065250
158Ovarian steroidogenesis_Homo sapiens_hsa049130.31861733
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27923965
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24802711
161Prion diseases_Homo sapiens_hsa050200.24380326
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.23681155
163Wnt signaling pathway_Homo sapiens_hsa043100.23207445
164Mineral absorption_Homo sapiens_hsa049780.21546759
165African trypanosomiasis_Homo sapiens_hsa051430.20708485
166Platelet activation_Homo sapiens_hsa046110.20675198
167HIF-1 signaling pathway_Homo sapiens_hsa040660.19114545

Most similar genes based on co-expression Upload to Enrichr

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