LINC00675

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of guanylate cyclase activity (GO:0031282)6.75272566
2intestinal absorption (GO:0050892)6.35595721
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)6.05485702
4cellular glucuronidation (GO:0052695)5.87338252
5angiotensin maturation (GO:0002003)5.77221623
6sulfate transmembrane transport (GO:1902358)5.73702476
7uronic acid metabolic process (GO:0006063)5.65515591
8glucuronate metabolic process (GO:0019585)5.65515591
9flavonoid metabolic process (GO:0009812)5.12405959
10epoxygenase P450 pathway (GO:0019373)5.11885272
11positive regulation of guanylate cyclase activity (GO:0031284)4.94712898
12bile acid and bile salt transport (GO:0015721)4.93425231
13renal system process involved in regulation of blood volume (GO:0001977)4.89420792
14positive regulation of respiratory burst (GO:0060267)4.87954896
15oligosaccharide biosynthetic process (GO:0009312)4.82194423
16regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.77953063
17endocrine process (GO:0050886)4.77953063
18regulation of systemic arterial blood pressure by hormone (GO:0001990)4.77953063
19receptor guanylyl cyclase signaling pathway (GO:0007168)4.77104943
20ethanol oxidation (GO:0006069)4.74774046
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.71162925
22calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.70345924
23sulfate transport (GO:0008272)4.65778624
24O-glycan processing (GO:0016266)4.47509757
25maintenance of gastrointestinal epithelium (GO:0030277)4.46184066
26NADH metabolic process (GO:0006734)4.45255871
27sperm capacitation (GO:0048240)4.27581074
28fat-soluble vitamin biosynthetic process (GO:0042362)4.24489816
29regulation of vitamin metabolic process (GO:0030656)4.20727771
30regulation of systemic arterial blood pressure (GO:0003073)4.13928065
31regulation of cGMP biosynthetic process (GO:0030826)4.10170839
32nucleoside diphosphate biosynthetic process (GO:0009133)4.04949825
33glomerular filtration (GO:0003094)4.02057562
34regulation of bile acid biosynthetic process (GO:0070857)3.99187677
35ethanol metabolic process (GO:0006067)3.98090520
36glucocorticoid biosynthetic process (GO:0006704)3.89114446
37positive regulation of pseudopodium assembly (GO:0031274)3.87064178
38regulation of cellular extravasation (GO:0002691)3.85532885
39desmosome organization (GO:0002934)3.84709341
40drug metabolic process (GO:0017144)3.83487816
41transcytosis (GO:0045056)3.82791722
42diacylglycerol metabolic process (GO:0046339)3.74207206
43regulation of respiratory burst (GO:0060263)3.67875538
44antimicrobial humoral response (GO:0019730)3.67759730
45digestive system process (GO:0022600)3.64995166
46renal filtration (GO:0097205)3.63754328
47cGMP-mediated signaling (GO:0019934)3.63585295
48digestion (GO:0007586)3.61191234
49bicarbonate transport (GO:0015701)3.60850133
50renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.56555969
51positive regulation of fatty acid beta-oxidation (GO:0032000)3.56305360
52antibacterial humoral response (GO:0019731)3.54177251
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.53198611
54receptor recycling (GO:0001881)3.52988617
55lipoprotein transport (GO:0042953)3.51348389
56excretion (GO:0007588)3.48785764
57regulation of cholesterol homeostasis (GO:2000188)3.47380724
58intestinal epithelial cell development (GO:0060576)3.45841957
59regulation of pseudopodium assembly (GO:0031272)3.44084331
60sodium ion homeostasis (GO:0055078)3.41276068
61phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.33934393
62regulation of cGMP metabolic process (GO:0030823)3.33651289
633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.30760351
64purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.30760351
65cellular response to pH (GO:0071467)3.29050878
66sulfur compound transport (GO:0072348)3.28237706
67hormone catabolic process (GO:0042447)3.27343022
68vitamin transmembrane transport (GO:0035461)3.23752021
69drug transmembrane transport (GO:0006855)3.23301795
70epithelial structure maintenance (GO:0010669)3.20382467
71urea cycle (GO:0000050)3.16986206
72phenylpropanoid metabolic process (GO:0009698)3.16700014
73multicellular organismal water homeostasis (GO:0050891)3.10446062
74sphingomyelin metabolic process (GO:0006684)3.05076988
75auditory receptor cell differentiation (GO:0042491)3.03293158
76urea metabolic process (GO:0019627)3.02841654
77positive regulation of glycoprotein metabolic process (GO:1903020)2.98728376
78drug transport (GO:0015893)2.97977094
79UDP-N-acetylglucosamine metabolic process (GO:0006047)2.97036968
80thrombin receptor signaling pathway (GO:0070493)2.96550127
81actin filament depolymerization (GO:0030042)2.94207981
82cGMP biosynthetic process (GO:0006182)2.93195083
83positive regulation of glycoprotein biosynthetic process (GO:0010560)2.92589950
84positive regulation of fatty acid oxidation (GO:0046321)2.90478256
85sexual reproduction (GO:0019953)2.90349454
86GDP-mannose metabolic process (GO:0019673)2.89863109
87drug catabolic process (GO:0042737)2.86668160
88positive regulation of lipid catabolic process (GO:0050996)2.86667805
89positive regulation of cGMP biosynthetic process (GO:0030828)2.85100946
90positive regulation of Cdc42 GTPase activity (GO:0043089)2.84758610
91amino-acid betaine transport (GO:0015838)2.84607581
92carnitine transport (GO:0015879)2.84607581
93COPII vesicle coating (GO:0048208)2.83628163
94regulation of protein glycosylation (GO:0060049)2.83468757
95vitamin transport (GO:0051180)2.82171433
96labyrinthine layer development (GO:0060711)2.82078930
97exogenous drug catabolic process (GO:0042738)2.81450612
98nucleotide-sugar biosynthetic process (GO:0009226)2.80919377
99fructose metabolic process (GO:0006000)2.78140218
100monovalent inorganic cation homeostasis (GO:0055067)2.76245327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.17529780
2SOX2_27498859_Chip-Seq_STOMACH_Mouse3.33284706
3GATA4_25053715_ChIP-Seq_YYC3_Human2.93341338
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88521719
5GATA6_25053715_ChIP-Seq_YYC3_Human2.80744361
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.79157876
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.72214489
8SOX2_20726797_ChIP-Seq_SW620_Human2.68080560
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.58786130
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.45058031
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.32657311
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.31120132
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.21604685
14FOXO3_23340844_ChIP-Seq_DLD1_Human2.21555923
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.15282133
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.15233105
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.13356537
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.12605732
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.12287545
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.07698486
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.07150357
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.02723356
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.92596709
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86313913
25AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.82866758
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.82421718
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.81769820
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78501746
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78152127
30KLF5_25053715_ChIP-Seq_YYC3_Human1.76713521
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75440962
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73928434
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67671141
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62439064
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.60207995
36FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.58468211
37RUNX1_27514584_Chip-Seq_MCF-7_Human1.58355862
38CDX2_22108803_ChIP-Seq_LS180_Human1.57726324
39PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.57472761
40ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.55630070
41KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48626154
42P63_26484246_Chip-Seq_KERATINOCYTES_Human1.47824854
43KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47756562
44FOXA1_25552417_ChIP-Seq_VCAP_Human1.44051245
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42142617
46RACK7_27058665_Chip-Seq_MCF-7_Human1.39735112
47DROSHA_22980978_ChIP-Seq_HELA_Human1.38525513
48ZNF217_24962896_ChIP-Seq_MCF-7_Human1.38175024
49LXR_22292898_ChIP-Seq_THP-1_Human1.35198085
50GATA3_24758297_ChIP-Seq_MCF-7_Human1.31302357
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30845143
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.28696257
53CEBPB_22108803_ChIP-Seq_LS180_Human1.26210043
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26144621
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.24932291
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24394884
57HNF4A_19822575_ChIP-Seq_HepG2_Human1.17663691
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.13075409
59BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12555074
60THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11904722
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07942602
62TP63_22573176_ChIP-Seq_HFKS_Human1.04334208
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04074092
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02659655
65RXR_22108803_ChIP-Seq_LS180_Human1.01936660
66GATA2_19941826_ChIP-Seq_K562_Human0.98968088
67SA1_27219007_Chip-Seq_Bcells_Human0.98929590
68CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98609285
69NANOG_20526341_ChIP-Seq_ESCs_Human0.97479263
70AHR_22903824_ChIP-Seq_MCF-7_Human0.95891808
71GATA1_19941826_ChIP-Seq_K562_Human0.95478960
72JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.94130348
73ZNF263_19887448_ChIP-Seq_K562_Human0.92782370
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92066809
75STAT1_20625510_ChIP-Seq_HELA_Human0.90906431
76CTCF_27219007_Chip-Seq_Bcells_Human0.90879697
77CLOCK_20551151_ChIP-Seq_293T_Human0.90592362
78AR_21909140_ChIP-Seq_LNCAP_Human0.90573066
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88517570
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88054217
81FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87713142
82TP63_23658742_ChIP-Seq_EP156T_Human0.86856824
83CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86708447
84PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85946485
85SRY_22984422_ChIP-ChIP_TESTIS_Rat0.85548340
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.84488875
87RAD21_21589869_ChIP-Seq_MESCs_Mouse0.83898849
88FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83604959
89BCL6_27268052_Chip-Seq_Bcells_Human0.82829245
90CREB1_26743006_Chip-Seq_LNCaP_Human0.82114111
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81113876
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79876133
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78678935
94TET1_21451524_ChIP-Seq_MESCs_Mouse0.77539997
95CTCF_20526341_ChIP-Seq_ESCs_Human0.77512742
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.77318515
97HNFA_21074721_ChIP-Seq_CACO-2_Human0.76776755
98CJUN_26792858_Chip-Seq_BT549_Human0.76078913
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75785202
100SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75522534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.74906848
2MP0002139_abnormal_hepatobiliary_system5.59956960
3MP0005360_urolithiasis4.40715587
4MP0008004_abnormal_stomach_pH3.82738480
5MP0005085_abnormal_gallbladder_physiolo3.76119400
6MP0004264_abnormal_extraembryonic_tissu3.55948447
7MP0005365_abnormal_bile_salt3.42338433
8MP0001664_abnormal_digestion3.26157649
9MP0004043_abnormal_pH_regulation3.15637597
10MP0001666_abnormal_nutrient_absorption3.12918313
11MP0010352_gastrointestinal_tract_polyps2.98137202
12MP0003866_abnormal_defecation2.80623630
13MP0010155_abnormal_intestine_physiology2.66538604
14MP0009379_abnormal_foot_pigmentation2.55976824
15MP0003868_abnormal_feces_composition2.52711442
16MP0003183_abnormal_peptide_metabolism2.45490561
17MP0001765_abnormal_ion_homeostasis2.29105091
18MP0000490_abnormal_crypts_of2.26741392
19MP0004019_abnormal_vitamin_homeostasis2.14852954
20MP0001873_stomach_inflammation2.08477668
21MP0001663_abnormal_digestive_system2.06309344
22MP0000477_abnormal_intestine_morphology2.06110231
23MP0004147_increased_porphyrin_level2.02585850
24MP0005670_abnormal_white_adipose2.02124890
25MP0002796_impaired_skin_barrier2.00116173
26MP0005381_digestive/alimentary_phenotyp1.89560887
27MP0002138_abnormal_hepatobiliary_system1.81163080
28MP0005409_darkened_coat_color1.73820448
29MP0005636_abnormal_mineral_homeostasis1.73222838
30MP0000462_abnormal_digestive_system1.62744678
31MP0003252_abnormal_bile_duct1.55744262
32MP0009643_abnormal_urine_homeostasis1.51152625
33MP0005166_decreased_susceptibility_to1.49725204
34MP0005451_abnormal_body_composition1.48122113
35MP0000678_abnormal_parathyroid_gland1.47998771
36MP0004782_abnormal_surfactant_physiolog1.43292026
37MP0009840_abnormal_foam_cell1.39122077
38MP0003879_abnormal_hair_cell1.38145334
39MP0005501_abnormal_skin_physiology1.32847877
40MP0003806_abnormal_nucleotide_metabolis1.29361384
41MP0002876_abnormal_thyroid_physiology1.28591668
42MP0000566_synostosis1.28508931
43MP0002098_abnormal_vibrissa_morphology1.27404636
44MP0001756_abnormal_urination1.24599891
45MP0000465_gastrointestinal_hemorrhage1.22635168
46MP0008875_abnormal_xenobiotic_pharmacok1.21482787
47MP0010329_abnormal_lipoprotein_level1.20862745
48MP0000470_abnormal_stomach_morphology1.20150780
49MP0002136_abnormal_kidney_physiology1.18043966
50MP0002009_preneoplasia1.15585591
51MP0005310_abnormal_salivary_gland1.13827168
52MP0005332_abnormal_amino_acid1.13590549
53MP0000537_abnormal_urethra_morphology1.12274160
54MP0000230_abnormal_systemic_arterial1.08491871
55MP0001188_hyperpigmentation1.08222929
56MP0010678_abnormal_skin_adnexa1.02622896
57MP0005666_abnormal_adipose_tissue0.99739944
58MP0009780_abnormal_chondrocyte_physiolo0.98958819
59MP0002118_abnormal_lipid_homeostasis0.98874198
60MP0002166_altered_tumor_susceptibility0.98169547
61MP0001764_abnormal_homeostasis0.92795478
62MP0002971_abnormal_brown_adipose0.89317136
63MP0001849_ear_inflammation0.88303610
64MP0005165_increased_susceptibility_to0.86506261
65MP0000467_abnormal_esophagus_morphology0.86264514
66MP0009115_abnormal_fat_cell0.84591094
67MP0005319_abnormal_enzyme/_coenzyme0.83329949
68MP0001485_abnormal_pinna_reflex0.82311826
69MP0001501_abnormal_sleep_pattern0.82163500
70MP0000538_abnormal_urinary_bladder0.77836432
71MP0003724_increased_susceptibility_to0.77791863
72MP0000609_abnormal_liver_physiology0.77783853
73MP0004858_abnormal_nervous_system0.76602116
74MP0005448_abnormal_energy_balance0.75791816
75MP0005367_renal/urinary_system_phenotyp0.75577516
76MP0000516_abnormal_urinary_system0.75577516
77MP0003300_gastrointestinal_ulcer0.74506827
78MP0003283_abnormal_digestive_organ0.73934209
79MP0001216_abnormal_epidermal_layer0.69816005
80MP0003453_abnormal_keratinocyte_physiol0.68735339
81MP0005584_abnormal_enzyme/coenzyme_acti0.68260519
82MP0008872_abnormal_physiological_respon0.67351159
83MP0001845_abnormal_inflammatory_respons0.62637301
84MP0002006_tumorigenesis0.62077625
85MP0003953_abnormal_hormone_level0.60980971
86MP0004947_skin_inflammation0.58309084
87MP0002896_abnormal_bone_mineralization0.58080104
88MP0009642_abnormal_blood_homeostasis0.56545098
89MP0000377_abnormal_hair_follicle0.54270181
90MP0009785_altered_susceptibility_to0.53638910
91MP0003315_abnormal_perineum_morphology0.53197661
92MP0002132_abnormal_respiratory_system0.51490590
93MP0005535_abnormal_body_temperature0.51191474
94MP0004484_altered_response_of0.51167470
95MP0003045_fibrosis0.48688334
96MP0002078_abnormal_glucose_homeostasis0.48510555
97MP0005275_abnormal_skin_tensile0.48322768
98MP0000681_abnormal_thyroid_gland0.46789021
99MP0003303_peritoneal_inflammation0.46274185
100MP0003693_abnormal_embryo_hatching0.45267131

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)9.21623370
2Decreased circulating renin level (HP:0003351)6.84767425
3Metabolic alkalosis (HP:0200114)6.61198667
4Abnormality of renin-angiotensin system (HP:0000847)6.31507706
5Abnormality of glutamine family amino acid metabolism (HP:0010902)5.60472479
6Abnormality of chloride homeostasis (HP:0011422)4.96312080
7Alkalosis (HP:0001948)4.80754190
8Malnutrition (HP:0004395)4.70214958
9Hyperaldosteronism (HP:0000859)4.65369351
10Flat acetabular roof (HP:0003180)4.55050243
11Abnormality of the vitamin B12 metabolism (HP:0004341)4.53181062
12Right ventricular cardiomyopathy (HP:0011663)4.46331672
13Abnormality of vitamin B metabolism (HP:0004340)4.35527873
14Ileus (HP:0002595)3.96175739
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.93484446
16Hyponatremia (HP:0002902)3.87122697
17Abnormality of vitamin metabolism (HP:0100508)3.75999336
18Abdominal distention (HP:0003270)3.67240926
19Intrahepatic cholestasis (HP:0001406)3.51943406
20Hydroxyprolinuria (HP:0003080)3.44542839
21Abnormality of proline metabolism (HP:0010907)3.44542839
22Hypokalemia (HP:0002900)3.40773426
23Hyperkalemia (HP:0002153)3.40242618
24Abnormality of potassium homeostasis (HP:0011042)3.33156344
25Fat malabsorption (HP:0002630)3.26929290
26Congenital sensorineural hearing impairment (HP:0008527)3.26373015
27Chronic diarrhea (HP:0002028)3.17858012
28Villous atrophy (HP:0011473)3.16260457
29Abnormality of small intestinal villus morphology (HP:0011472)3.16260457
30Hemorrhage of the eye (HP:0011885)3.08860040
31Flattened epiphyses (HP:0003071)2.93270373
32Conjugated hyperbilirubinemia (HP:0002908)2.93176156
33Abnormality of sodium homeostasis (HP:0010931)2.91006569
34Abnormal tarsal ossification (HP:0008369)2.86447143
35Abnormality of the distal phalanx of the thumb (HP:0009617)2.83726347
36Hyperparathyroidism (HP:0000843)2.80611006
37Widely patent fontanelles and sutures (HP:0004492)2.78121565
38Adrenal overactivity (HP:0002717)2.70694501
39Dehydration (HP:0001944)2.67308533
40Focal segmental glomerulosclerosis (HP:0000097)2.65313682
41Neonatal short-limb short stature (HP:0008921)2.64974188
42Pili torti (HP:0003777)2.64961838
43Hypotension (HP:0002615)2.58873459
44Hyperammonemia (HP:0001987)2.54091358
45Thin bony cortex (HP:0002753)2.52827017
46Abnormal biliary tract morphology (HP:0012440)2.48701248
47Syncope (HP:0001279)2.48580171
48Acanthocytosis (HP:0001927)2.47457069
49Chronic bronchitis (HP:0004469)2.46981133
50Eczematoid dermatitis (HP:0000976)2.45067480
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40947060
52Dicarboxylic aciduria (HP:0003215)2.40947060
53Megaloblastic anemia (HP:0001889)2.38490997
54Systemic lupus erythematosus (HP:0002725)2.37070598
55Abnormality of the nasal mucosa (HP:0000433)2.35454528
56Increased purine levels (HP:0004368)2.34771002
57Hyperuricemia (HP:0002149)2.34771002
58Ventricular fibrillation (HP:0001663)2.33587190
59Glomerulosclerosis (HP:0000096)2.28031857
60Pigmentary retinal degeneration (HP:0001146)2.25632490
61Visceral angiomatosis (HP:0100761)2.24768060
62Flat capital femoral epiphysis (HP:0003370)2.18324985
63Glycosuria (HP:0003076)2.18075276
64Abnormality of urine glucose concentration (HP:0011016)2.18075276
65Confusion (HP:0001289)2.11552768
66Abnormality of carpal bone ossification (HP:0006257)2.10527754
67Wide cranial sutures (HP:0010537)2.08516196
68Renal tubular acidosis (HP:0001947)2.06100436
69Abnormal hair laboratory examination (HP:0003328)2.04880448
70Renal salt wasting (HP:0000127)2.01990357
71Symptomatic seizures (HP:0011145)2.01534274
72Spinal cord compression (HP:0002176)1.99187359
73Hypobetalipoproteinemia (HP:0003563)1.97525851
74Curly hair (HP:0002212)1.97419592
75Cone-rod dystrophy (HP:0000548)1.92445075
76Nasal polyposis (HP:0100582)1.91520009
77Hemangiomatosis (HP:0007461)1.91326836
78Metabolic acidosis (HP:0001942)1.90958535
79Abnormality of purine metabolism (HP:0004352)1.90498408
80Growth hormone excess (HP:0000845)1.87674355
81Palpitations (HP:0001962)1.87548057
82Hyperphosphatemia (HP:0002905)1.87523020
83Gout (HP:0001997)1.87300980
84Protuberant abdomen (HP:0001538)1.86873691
85Proximal tubulopathy (HP:0000114)1.86712328
86Late onset (HP:0003584)1.84938265
87Subcapsular cataract (HP:0000523)1.84749628
88Ankle clonus (HP:0011448)1.79978567
89Cerebral palsy (HP:0100021)1.77864196
90Abnormality of the costochondral junction (HP:0000919)1.76726846
91Nephrolithiasis (HP:0000787)1.75719000
92Abnormal hand bone ossification (HP:0010660)1.75668210
93Abnormality of nucleobase metabolism (HP:0010932)1.73983337
94Abnormal foot bone ossification (HP:0010675)1.71724667
95Xanthomatosis (HP:0000991)1.71295417
96Amelogenesis imperfecta (HP:0000705)1.70647069
97Enlarged epiphyses (HP:0010580)1.69792976
98Abnormality of the 1st metacarpal (HP:0010009)1.68517991
99Vertebral clefting (HP:0008428)1.68307989
100Abnormal ossification of hand bones (HP:0005921)1.64342713

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.03791817
2EPHA25.26865898
3ACVR1B5.08199857
4PIK3CA4.63054261
5RIPK14.41220979
6LMTK23.51331428
7ERN12.92804659
8STK392.78924745
9PRKG22.65241757
10MAP3K102.55139182
11EPHA32.26498534
12MET2.25404272
13EPHB22.16612280
14MAP3K21.79267683
15OXSR11.75742498
16MYLK1.65093605
17PTK61.60564461
18FGFR41.48322785
19TESK11.47482006
20MST41.36047805
21EPHB11.34062037
22STK241.30858626
23MAP3K121.27478116
24PIK3CG1.23075456
25FGFR31.10761202
26MAP3K11.05062539
27NEK11.03869170
28FER0.99941495
29PDPK10.98328041
30DDR20.93358586
31MAP2K20.92661854
32AKT30.88362811
33TAOK10.85392756
34DYRK1B0.84221645
35PIM20.82210939
36WNK40.81633771
37PINK10.80281536
38NLK0.76371342
39TESK20.75772434
40INSRR0.70832504
41PRKAA20.69138268
42PDK10.66342356
43ERBB20.66302996
44MATK0.65237749
45MAPK150.64850298
46PRPF4B0.63229328
47CAMK2D0.61740593
48DMPK0.59993913
49MAPK110.58401247
50GRK60.58373407
51CDC42BPA0.56652500
52IRAK10.54320377
53TNIK0.52562554
54STK380.52430826
55MAP3K30.52176308
56LATS10.51395482
57MAP2K60.50888721
58PTK20.50056365
59PDK20.48883444
60STK38L0.47587209
61NME10.46927235
62TRIB30.46752996
63PAK40.44232648
64RPS6KA20.42847399
65TYK20.42378942
66KSR20.39889866
67NEK60.38890028
68ZAP700.37836260
69PRKACG0.35407790
70PLK40.35357205
71RET0.34410160
72RIPK40.33142917
73PRKCA0.32322823
74ABL20.31822724
75MAPKAPK20.31381585
76SGK2230.30721656
77SGK4940.30721656
78MAP2K10.29817195
79CSNK1A10.29470431
80SRC0.29319637
81MAPKAPK30.29259741
82SMG10.29196921
83PRKCI0.28551624
84EEF2K0.24866958
85RPS6KB10.23520548
86DAPK30.21749912
87GRK10.20309179
88SGK30.19754536
89PRKCZ0.17185045
90CSK0.16439525
91JAK20.15935789
92ROCK10.15798678
93TBK10.15678252
94LRRK20.14163218
95IRAK30.13344705
96PRKCD0.11767127
97MAP3K110.11450551
98TYRO30.11301447
99SGK20.11166728
100CASK0.11155115

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004603.92030731
2Sulfur metabolism_Homo sapiens_hsa009203.91331221
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.28711700
4Fat digestion and absorption_Homo sapiens_hsa049753.23175929
5Nitrogen metabolism_Homo sapiens_hsa009102.91518796
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88062054
7Caffeine metabolism_Homo sapiens_hsa002322.78889361
8Mineral absorption_Homo sapiens_hsa049782.74590143
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.65173883
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.63319437
11Vitamin digestion and absorption_Homo sapiens_hsa049772.43771321
12Renin-angiotensin system_Homo sapiens_hsa046142.17918248
13Histidine metabolism_Homo sapiens_hsa003402.17915131
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16517107
15Chemical carcinogenesis_Homo sapiens_hsa052042.15112399
16Retinol metabolism_Homo sapiens_hsa008302.13580230
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.11642658
18Arginine biosynthesis_Homo sapiens_hsa002202.06547986
19Starch and sucrose metabolism_Homo sapiens_hsa005002.05026817
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.98747517
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.96503903
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.93778420
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82986757
24Bile secretion_Homo sapiens_hsa049761.74336454
25Fatty acid degradation_Homo sapiens_hsa000711.71956514
26PPAR signaling pathway_Homo sapiens_hsa033201.65907867
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49953793
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.48509735
29Fructose and mannose metabolism_Homo sapiens_hsa000511.48344571
30Protein digestion and absorption_Homo sapiens_hsa049741.48265227
31Pancreatic secretion_Homo sapiens_hsa049721.40891659
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36821421
33Linoleic acid metabolism_Homo sapiens_hsa005911.32447815
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.27473946
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19610836
36Arachidonic acid metabolism_Homo sapiens_hsa005901.17402135
37Arginine and proline metabolism_Homo sapiens_hsa003301.09448043
38Galactose metabolism_Homo sapiens_hsa000521.08808648
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04964183
40Glycerolipid metabolism_Homo sapiens_hsa005611.03863187
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98916183
42Phenylalanine metabolism_Homo sapiens_hsa003600.97357699
43Tryptophan metabolism_Homo sapiens_hsa003800.96375376
44Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92432892
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.92001781
46Glutathione metabolism_Homo sapiens_hsa004800.86063567
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84276509
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80684250
49Sulfur relay system_Homo sapiens_hsa041220.78262909
50Butanoate metabolism_Homo sapiens_hsa006500.74072044
51Tight junction_Homo sapiens_hsa045300.73174935
52Tyrosine metabolism_Homo sapiens_hsa003500.69995520
53Fatty acid metabolism_Homo sapiens_hsa012120.68041096
54Ether lipid metabolism_Homo sapiens_hsa005650.66885368
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60670549
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.60614211
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.60029870
58Sphingolipid metabolism_Homo sapiens_hsa006000.59462204
59Fatty acid biosynthesis_Homo sapiens_hsa000610.57962884
60Collecting duct acid secretion_Homo sapiens_hsa049660.57942213
61Propanoate metabolism_Homo sapiens_hsa006400.57324520
62Peroxisome_Homo sapiens_hsa041460.56968918
63Renin secretion_Homo sapiens_hsa049240.55553659
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53136343
65Glycerophospholipid metabolism_Homo sapiens_hsa005640.51710637
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.51226137
67Hepatitis C_Homo sapiens_hsa051600.50202231
68Other glycan degradation_Homo sapiens_hsa005110.46268332
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.44130197
70Asthma_Homo sapiens_hsa053100.37992824
71Gastric acid secretion_Homo sapiens_hsa049710.37768548
72Insulin resistance_Homo sapiens_hsa049310.34487367
73Carbon metabolism_Homo sapiens_hsa012000.28703600
74Pyruvate metabolism_Homo sapiens_hsa006200.28509774
75Thyroid hormone synthesis_Homo sapiens_hsa049180.28224078
76Metabolic pathways_Homo sapiens_hsa011000.26376680
77Folate biosynthesis_Homo sapiens_hsa007900.24713031
78ABC transporters_Homo sapiens_hsa020100.20208592
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.17118643
80Vibrio cholerae infection_Homo sapiens_hsa051100.16071577
81Allograft rejection_Homo sapiens_hsa053300.14493225
82Salivary secretion_Homo sapiens_hsa049700.13002958
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.12068312
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.12040530
85Autoimmune thyroid disease_Homo sapiens_hsa053200.12011805
86Inositol phosphate metabolism_Homo sapiens_hsa005620.11899132
87beta-Alanine metabolism_Homo sapiens_hsa004100.11656963
88Type I diabetes mellitus_Homo sapiens_hsa049400.11623069
89Glucagon signaling pathway_Homo sapiens_hsa049220.11261072
90Insulin secretion_Homo sapiens_hsa049110.09520376
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.09213032
92Cocaine addiction_Homo sapiens_hsa050300.07816470
93Graft-versus-host disease_Homo sapiens_hsa053320.06920982
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.06307168
95Staphylococcus aureus infection_Homo sapiens_hsa051500.04734181
96Pertussis_Homo sapiens_hsa051330.03732653
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03624245
98Adherens junction_Homo sapiens_hsa045200.01649776
99AMPK signaling pathway_Homo sapiens_hsa041520.01392393
100Choline metabolism in cancer_Homo sapiens_hsa052310.01390333

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