LINC00493

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.15781052
2ATP synthesis coupled proton transport (GO:0015986)7.17796497
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.17796497
4viral transcription (GO:0019083)6.74544916
5translational termination (GO:0006415)6.58143754
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.29046827
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.96471591
8respiratory electron transport chain (GO:0022904)5.95883178
9cotranslational protein targeting to membrane (GO:0006613)5.93782854
10protein targeting to ER (GO:0045047)5.89213243
11ribosomal small subunit assembly (GO:0000028)5.87042207
12electron transport chain (GO:0022900)5.85443437
13establishment of protein localization to endoplasmic reticulum (GO:0072599)5.67956764
14establishment of protein localization to mitochondrial membrane (GO:0090151)5.67760677
15protein localization to endoplasmic reticulum (GO:0070972)5.56063019
16chaperone-mediated protein transport (GO:0072321)5.50749591
17ribosomal small subunit biogenesis (GO:0042274)5.47023023
18translational elongation (GO:0006414)5.45937434
19maturation of SSU-rRNA (GO:0030490)5.09595260
20protein complex biogenesis (GO:0070271)5.08148888
21cellular protein complex disassembly (GO:0043624)4.97322545
22viral life cycle (GO:0019058)4.95945484
23mitochondrial respiratory chain complex assembly (GO:0033108)4.77244535
24protein neddylation (GO:0045116)4.76196972
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.75073308
26translational initiation (GO:0006413)4.64468626
27mitochondrial respiratory chain complex I assembly (GO:0032981)4.60792616
28NADH dehydrogenase complex assembly (GO:0010257)4.60792616
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.60792616
30ribosomal large subunit biogenesis (GO:0042273)4.46561905
31translation (GO:0006412)4.21965462
32proteasome assembly (GO:0043248)4.14650799
33hydrogen ion transmembrane transport (GO:1902600)4.12860577
34protein complex disassembly (GO:0043241)4.11153002
35regulation of mitochondrial translation (GO:0070129)4.07143037
36ATP biosynthetic process (GO:0006754)4.00647617
37macromolecular complex disassembly (GO:0032984)3.95804814
38protein targeting to membrane (GO:0006612)3.81965702
39purine nucleoside triphosphate biosynthetic process (GO:0009145)3.79592023
40purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.78573467
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.72937993
42proton transport (GO:0015992)3.70150425
43termination of RNA polymerase III transcription (GO:0006386)3.67840202
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.67840202
45respiratory chain complex IV assembly (GO:0008535)3.65259322
46hydrogen transport (GO:0006818)3.63928473
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.58130753
48nuclear-transcribed mRNA catabolic process (GO:0000956)3.55255287
49cytochrome complex assembly (GO:0017004)3.53797366
50rRNA modification (GO:0000154)3.45440823
51sequestering of actin monomers (GO:0042989)3.36263827
52inner mitochondrial membrane organization (GO:0007007)3.33758569
53mRNA catabolic process (GO:0006402)3.32281810
54protein targeting to mitochondrion (GO:0006626)3.30485671
55intracellular protein transmembrane import (GO:0044743)3.29336414
56ribonucleoside triphosphate biosynthetic process (GO:0009201)3.28645306
57behavioral response to nicotine (GO:0035095)3.24074938
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22437526
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22437526
60epithelial cilium movement (GO:0003351)3.22361307
61cullin deneddylation (GO:0010388)3.21630441
62cellular component biogenesis (GO:0044085)3.21082075
63establishment of protein localization to mitochondrion (GO:0072655)3.19443961
64protein-cofactor linkage (GO:0018065)3.15011376
65platelet dense granule organization (GO:0060155)3.12303137
66protein localization to mitochondrion (GO:0070585)3.11761194
67GTP biosynthetic process (GO:0006183)3.08671991
68nucleoside triphosphate biosynthetic process (GO:0009142)3.07385138
69oxidative phosphorylation (GO:0006119)3.06710130
70negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05595420
71spliceosomal snRNP assembly (GO:0000387)3.02346453
72water-soluble vitamin biosynthetic process (GO:0042364)3.00986666
73RNA catabolic process (GO:0006401)2.98025424
74DNA damage response, detection of DNA damage (GO:0042769)2.97932996
75mitochondrial transport (GO:0006839)2.96604823
76aerobic respiration (GO:0009060)2.94173588
77chromatin remodeling at centromere (GO:0031055)2.92733890
78protein deneddylation (GO:0000338)2.92357679
79CENP-A containing nucleosome assembly (GO:0034080)2.83532376
80regulation of oxidative phosphorylation (GO:0002082)2.80547642
81purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.80176278
82purine nucleoside monophosphate biosynthetic process (GO:0009127)2.80176278
83ribonucleoprotein complex biogenesis (GO:0022613)2.79413595
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78963652
85rRNA methylation (GO:0031167)2.78025074
86pseudouridine synthesis (GO:0001522)2.76220521
87protein targeting (GO:0006605)2.76123400
88regulation of cellular amino acid metabolic process (GO:0006521)2.75616192
89regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74498525
90intraciliary transport (GO:0042073)2.72787182
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72535932
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67446696
93negative regulation of ligase activity (GO:0051352)2.65199314
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.65199314
95establishment of protein localization to membrane (GO:0090150)2.64701671
96organelle disassembly (GO:1903008)2.62718645
97peptidyl-histidine modification (GO:0018202)2.62497880
98rRNA processing (GO:0006364)2.62247766
99spliceosomal complex assembly (GO:0000245)2.61655194
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.59727348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.79447579
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.65558224
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.64198305
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.29951981
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.98136125
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.35615118
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.30195386
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91369221
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.91159547
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76300384
11ELK1_19687146_ChIP-ChIP_HELA_Human2.71448546
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61007584
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.57143554
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.52100382
15VDR_22108803_ChIP-Seq_LS180_Human2.38715950
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36085446
17VDR_23849224_ChIP-Seq_CD4+_Human2.35174164
18ZNF274_21170338_ChIP-Seq_K562_Hela2.05088217
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.03255303
20FUS_26573619_Chip-Seq_HEK293_Human1.97375323
21FOXP3_21729870_ChIP-Seq_TREG_Human1.96825965
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.94429584
23MYC_18940864_ChIP-ChIP_HL60_Human1.93028513
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91629870
25EWS_26573619_Chip-Seq_HEK293_Human1.83565368
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80491225
27IGF1R_20145208_ChIP-Seq_DFB_Human1.75767266
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62353402
29TTF2_22483619_ChIP-Seq_HELA_Human1.61198922
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.55078409
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54579787
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.52339567
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52215260
34PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47425138
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44355955
36XRN2_22483619_ChIP-Seq_HELA_Human1.42861403
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42644707
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38576237
39DCP1A_22483619_ChIP-Seq_HELA_Human1.37952214
40P300_19829295_ChIP-Seq_ESCs_Human1.37430286
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37409062
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35319813
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34597364
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.34219578
45ELK1_22589737_ChIP-Seq_MCF10A_Human1.33874791
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31141044
47E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30762973
48MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30597462
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30221246
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28638980
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28535627
52GBX2_23144817_ChIP-Seq_PC3_Human1.28517511
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27640957
54GABP_19822575_ChIP-Seq_HepG2_Human1.23912343
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.23881380
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23705301
57EZH2_22144423_ChIP-Seq_EOC_Human1.19589851
58TAF15_26573619_Chip-Seq_HEK293_Human1.18284386
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17070870
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.16315921
61CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16169651
62TP53_22573176_ChIP-Seq_HFKS_Human1.16005579
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15199224
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14845465
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.14793632
66SOX2_16153702_ChIP-ChIP_HESCs_Human1.13691846
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13338058
68ER_23166858_ChIP-Seq_MCF-7_Human1.11394936
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10511493
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09431224
71CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05826788
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04757246
73HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03948095
74HTT_18923047_ChIP-ChIP_STHdh_Human1.02496472
75SOX2_19829295_ChIP-Seq_ESCs_Human0.97876219
76NANOG_19829295_ChIP-Seq_ESCs_Human0.97876219
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95849702
78NANOG_16153702_ChIP-ChIP_HESCs_Human0.95662743
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.95532914
80FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95532914
81IRF1_19129219_ChIP-ChIP_H3396_Human0.92636252
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91436867
83AR_20517297_ChIP-Seq_VCAP_Human0.91416578
84ERG_20517297_ChIP-Seq_VCAP_Human0.90891041
85NCOR_22424771_ChIP-Seq_293T_Human0.87234901
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.86592937
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.84998769
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.83997269
89CBP_20019798_ChIP-Seq_JUKART_Human0.83117485
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83117485
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.82273769
92NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81624237
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81041656
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.80269595
95CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.79813348
96TP63_19390658_ChIP-ChIP_HaCaT_Human0.79648353
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.79426514
98CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79292093
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.78603220
100RNF2_27304074_Chip-Seq_NSC_Mouse0.78481788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.66316082
2MP0002837_dystrophic_cardiac_calcinosis3.77608420
3MP0003136_yellow_coat_color3.57318391
4MP0003806_abnormal_nucleotide_metabolis3.07968796
5MP0006292_abnormal_olfactory_placode2.76195195
6MP0006072_abnormal_retinal_apoptosis2.66915517
7MP0002938_white_spotting2.57002212
8MP0000372_irregular_coat_pigmentation2.36804576
9MP0001529_abnormal_vocalization2.05456091
10MP0002277_abnormal_respiratory_mucosa1.98889327
11MP0006036_abnormal_mitochondrial_physio1.98183228
12MP0003186_abnormal_redox_activity1.95686667
13MP0003011_delayed_dark_adaptation1.93800457
14MP0003880_abnormal_central_pattern1.87662833
15MP0002638_abnormal_pupillary_reflex1.82701309
16MP0001984_abnormal_olfaction1.80130828
17MP0002102_abnormal_ear_morphology1.75236427
18MP0008058_abnormal_DNA_repair1.71915644
19MP0001905_abnormal_dopamine_level1.67972471
20MP0003195_calcinosis1.63522424
21MP0005084_abnormal_gallbladder_morpholo1.63057909
22MP0004142_abnormal_muscle_tone1.62917688
23MP0010030_abnormal_orbit_morphology1.59195343
24MP0005253_abnormal_eye_physiology1.55605714
25MP0005646_abnormal_pituitary_gland1.54631715
26MP0003718_maternal_effect1.54107258
27MP0000566_synostosis1.53006802
28MP0008789_abnormal_olfactory_epithelium1.49409748
29MP0004215_abnormal_myocardial_fiber1.49115883
30MP0002234_abnormal_pharynx_morphology1.48532224
31MP0000631_abnormal_neuroendocrine_gland1.45615085
32MP0004133_heterotaxia1.45504172
33MP0002736_abnormal_nociception_after1.42958651
34MP0003315_abnormal_perineum_morphology1.41937671
35MP0001293_anophthalmia1.41566856
36MP0008995_early_reproductive_senescence1.41488073
37MP0008875_abnormal_xenobiotic_pharmacok1.41263774
38MP0005551_abnormal_eye_electrophysiolog1.39958645
39MP0004145_abnormal_muscle_electrophysio1.38488927
40MP0000749_muscle_degeneration1.38088042
41MP0010386_abnormal_urinary_bladder1.35885165
42MP0008877_abnormal_DNA_methylation1.35740369
43MP0006035_abnormal_mitochondrial_morpho1.34969233
44MP0001968_abnormal_touch/_nociception1.34508764
45MP0009697_abnormal_copulation1.32891467
46MP0001485_abnormal_pinna_reflex1.26208828
47MP0002160_abnormal_reproductive_system1.25989077
48MP0005075_abnormal_melanosome_morpholog1.22122389
49MP0002653_abnormal_ependyma_morphology1.21481239
50MP0003938_abnormal_ear_development1.16710671
51MP0006276_abnormal_autonomic_nervous1.14409721
52MP0005408_hypopigmentation1.13934175
53MP0001764_abnormal_homeostasis1.10858532
54MP0002272_abnormal_nervous_system1.06459731
55MP0002163_abnormal_gland_morphology1.05382780
56MP0000049_abnormal_middle_ear1.05303883
57MP0005394_taste/olfaction_phenotype1.04055544
58MP0005499_abnormal_olfactory_system1.04055544
59MP0002282_abnormal_trachea_morphology1.01018706
60MP0009745_abnormal_behavioral_response1.00297034
61MP0003646_muscle_fatigue1.00047340
62MP0003693_abnormal_embryo_hatching0.99607202
63MP0002233_abnormal_nose_morphology0.98955514
64MP0009046_muscle_twitch0.96333051
65MP0002095_abnormal_skin_pigmentation0.95766445
66MP0005389_reproductive_system_phenotype0.94186678
67MP0002876_abnormal_thyroid_physiology0.92643265
68MP0005187_abnormal_penis_morphology0.92452138
69MP0003137_abnormal_impulse_conducting0.91304144
70MP0005410_abnormal_fertilization0.91037241
71MP0004147_increased_porphyrin_level0.90521639
72MP0005332_abnormal_amino_acid0.86255310
73MP0000026_abnormal_inner_ear0.86023724
74MP0005391_vision/eye_phenotype0.85178052
75MP0003283_abnormal_digestive_organ0.84890823
76MP0004084_abnormal_cardiac_muscle0.84564888
77MP0002751_abnormal_autonomic_nervous0.83904123
78MP0003937_abnormal_limbs/digits/tail_de0.83249239
79MP0008872_abnormal_physiological_respon0.83185947
80MP0003567_abnormal_fetal_cardiomyocyte0.83184136
81MP0005195_abnormal_posterior_eye0.83019746
82MP0001188_hyperpigmentation0.82223872
83MP0005379_endocrine/exocrine_gland_phen0.82111792
84MP0003787_abnormal_imprinting0.81911252
85MP0002210_abnormal_sex_determination0.81349521
86MP0003890_abnormal_embryonic-extraembry0.79239986
87MP0001929_abnormal_gametogenesis0.78902067
88MP0002090_abnormal_vision0.77681301
89MP0003121_genomic_imprinting0.77660933
90MP0002132_abnormal_respiratory_system0.77599020
91MP0005645_abnormal_hypothalamus_physiol0.76767104
92MP0003122_maternal_imprinting0.75686111
93MP0001286_abnormal_eye_development0.74901360
94MP0002752_abnormal_somatic_nervous0.74616223
95MP0002735_abnormal_chemical_nociception0.74241516
96MP0005174_abnormal_tail_pigmentation0.72522929
97MP0001919_abnormal_reproductive_system0.72491646
98MP0000653_abnormal_sex_gland0.72156988
99MP0001324_abnormal_eye_pigmentation0.71229756
100MP0003786_premature_aging0.71073134

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.53929727
2Mitochondrial inheritance (HP:0001427)4.98583528
3Abnormal mitochondria in muscle tissue (HP:0008316)4.96871475
4Increased hepatocellular lipid droplets (HP:0006565)4.89974491
5Acute encephalopathy (HP:0006846)4.79538136
6Lipid accumulation in hepatocytes (HP:0006561)4.76427848
7Progressive macrocephaly (HP:0004481)4.68489786
8Increased CSF lactate (HP:0002490)4.30344485
9Renal Fanconi syndrome (HP:0001994)4.17547470
10Hepatocellular necrosis (HP:0001404)4.09420434
11Abnormal number of erythroid precursors (HP:0012131)4.06131208
12Abnormality of cells of the erythroid lineage (HP:0012130)4.04881757
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.91374845
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.91374845
15Hepatic necrosis (HP:0002605)3.88319001
16Macrocytic anemia (HP:0001972)3.56210107
173-Methylglutaconic aciduria (HP:0003535)3.49395546
18Reticulocytopenia (HP:0001896)3.47078474
19Increased intramyocellular lipid droplets (HP:0012240)3.43299330
20Cerebral edema (HP:0002181)3.40073121
21Exertional dyspnea (HP:0002875)3.23780109
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.21829965
23Pancreatic cysts (HP:0001737)3.20110209
24Congenital, generalized hypertrichosis (HP:0004540)3.17695382
25Increased muscle lipid content (HP:0009058)3.04737800
26Pancreatic fibrosis (HP:0100732)2.98932359
27True hermaphroditism (HP:0010459)2.86876594
28Molar tooth sign on MRI (HP:0002419)2.77588764
29Abnormality of midbrain morphology (HP:0002418)2.77588764
30Optic disc pallor (HP:0000543)2.75326213
31Abnormality of renal resorption (HP:0011038)2.74034785
32Exercise intolerance (HP:0003546)2.73241061
33Lactic acidosis (HP:0003128)2.72031099
34Respiratory failure (HP:0002878)2.69689325
35Type I transferrin isoform profile (HP:0003642)2.56814378
36Glycosuria (HP:0003076)2.56281841
37Abnormality of urine glucose concentration (HP:0011016)2.56281841
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52901426
39Methylmalonic acidemia (HP:0002912)2.52653591
40Respiratory difficulties (HP:0002880)2.52071685
41Medial flaring of the eyebrow (HP:0010747)2.50503414
42Increased serum lactate (HP:0002151)2.49979640
43Reduced antithrombin III activity (HP:0001976)2.46919245
44Nephronophthisis (HP:0000090)2.45884609
45Hypothermia (HP:0002045)2.42529976
46Abnormal ciliary motility (HP:0012262)2.39389245
47Leukodystrophy (HP:0002415)2.36927199
48Pallor (HP:0000980)2.35989056
49Lethargy (HP:0001254)2.34761691
50Generalized aminoaciduria (HP:0002909)2.31231107
51Hyperglycinemia (HP:0002154)2.29696709
52Aplastic anemia (HP:0001915)2.29666743
53Hyperphosphaturia (HP:0003109)2.29481638
54Abnormal respiratory motile cilium physiology (HP:0012261)2.26290939
55Septo-optic dysplasia (HP:0100842)2.19446382
56Abnormal respiratory motile cilium morphology (HP:0005938)2.11836681
57Abnormal respiratory epithelium morphology (HP:0012253)2.11836681
58Methylmalonic aciduria (HP:0012120)2.07947334
59Male pseudohermaphroditism (HP:0000037)2.04313008
60Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03357670
61Abnormal protein glycosylation (HP:0012346)2.02282022
62Abnormal glycosylation (HP:0012345)2.02282022
63Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02282022
64Abnormal protein N-linked glycosylation (HP:0012347)2.02282022
65Sclerocornea (HP:0000647)1.97267269
66Colon cancer (HP:0003003)1.97032085
67Oral leukoplakia (HP:0002745)1.93074641
68Type II lissencephaly (HP:0007260)1.92925589
69Abnormality of the renal medulla (HP:0100957)1.92920814
70Absent thumb (HP:0009777)1.91211799
71X-linked dominant inheritance (HP:0001423)1.91109014
72Concave nail (HP:0001598)1.90110020
73Congenital primary aphakia (HP:0007707)1.87499516
74Rhinitis (HP:0012384)1.87488789
75Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83730138
76Gait imbalance (HP:0002141)1.83721756
77CNS demyelination (HP:0007305)1.80795538
78Abnormality of the labia minora (HP:0012880)1.78290376
79Abnormality of methionine metabolism (HP:0010901)1.77821096
80Cystic liver disease (HP:0006706)1.77478096
81Absent/shortened dynein arms (HP:0200106)1.76882202
82Dynein arm defect of respiratory motile cilia (HP:0012255)1.76882202
83Anencephaly (HP:0002323)1.75527918
84Abnormality of the renal cortex (HP:0011035)1.71598928
85Hyperglycinuria (HP:0003108)1.69709309
86Nephrogenic diabetes insipidus (HP:0009806)1.69526356
87Stenosis of the external auditory canal (HP:0000402)1.68220034
88Hypoplasia of the pons (HP:0012110)1.66373412
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.66065253
90Anophthalmia (HP:0000528)1.65836153
91Abnormality of serum amino acid levels (HP:0003112)1.64872122
92Aplasia/hypoplasia of the uterus (HP:0008684)1.64694771
93Abnormality of the ileum (HP:0001549)1.64320107
94Abnormal urine phosphate concentration (HP:0012599)1.63179242
95Optic nerve hypoplasia (HP:0000609)1.63164963
96Muscle hypertrophy of the lower extremities (HP:0008968)1.62422823
97Meckel diverticulum (HP:0002245)1.62395152
98Triphalangeal thumb (HP:0001199)1.62282356
99Absent septum pellucidum (HP:0001331)1.61445883
100Abnormality of the pons (HP:0007361)1.61129480

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.65418282
2PINK13.58473429
3TLK13.02296403
4ZAK2.94951395
5STK162.55957432
6VRK12.49883653
7BUB12.22343868
8BMPR1B2.19902324
9MAP4K22.17848587
10OBSCN2.08627871
11WNK32.05106060
12NME11.90365076
13NUAK11.85904803
14SRPK11.68178359
15DYRK21.62833302
16MST41.60670682
17GRK11.57794347
18BCKDK1.56719514
19ADRBK21.56494760
20TNIK1.55495215
21FRK1.50983266
22CDC71.50054764
23NME21.49257105
24TAF11.40124835
25EIF2AK31.38964977
26DYRK31.30016393
27MAP3K121.29913676
28INSRR1.29148699
29MUSK1.28368970
30MAP2K71.26879243
31CDK191.25805156
32WEE11.24787047
33MARK31.23297287
34MAPK151.22804265
35PLK31.15800213
36PBK1.13914156
37CASK1.13313996
38CCNB11.12596645
39PNCK1.07723514
40NEK11.07628998
41CSNK1G11.06954888
42CSNK1G31.04516567
43PASK1.01031184
44CSNK1G21.00315412
45STK38L0.94702176
46PHKG20.94428974
47PHKG10.94428974
48TIE10.93007494
49DAPK30.92845977
50FGFR20.91369704
51MAP3K40.90375574
52PIK3CA0.88351474
53OXSR10.86167319
54RPS6KA50.84719871
55MYLK0.84364911
56PLK40.84074934
57NEK20.82159822
58TRIM280.81833275
59MKNK10.80139457
60TAOK30.78601793
61PRKCG0.76555137
62MAPK130.76479087
63PLK10.75640312
64AURKB0.75018561
65TGFBR10.72981168
66CDK30.69266269
67CSNK1A1L0.68815942
68MKNK20.68237678
69CSNK2A20.67426833
70BRSK20.66083439
71CSNK2A10.62462488
72PRKCE0.61888105
73CDK80.61062325
74ADRBK10.53536268
75ERBB30.53190838
76EPHB20.52548467
77ARAF0.50765461
78MAPKAPK30.50383247
79WNK40.48101886
80PAK30.47239471
81PRKACA0.43278970
82PRKG10.43187616
83CSNK1A10.42563676
84PRKCQ0.40822723
85MAPKAPK50.40528084
86UHMK10.40416872
87TTK0.40369728
88ABL20.39767625
89AURKA0.38667104
90CHEK20.38173657
91GRK50.35932694
92STK40.35171400
93ILK0.34537896
94GRK70.32939061
95NLK0.32109115
96PRKACB0.31184874
97CAMK2A0.31090312
98PKN10.30934224
99ATM0.29860886
100STK30.29738137

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.50719469
2Oxidative phosphorylation_Homo sapiens_hsa001905.22649755
3Parkinsons disease_Homo sapiens_hsa050124.45099224
4Proteasome_Homo sapiens_hsa030503.38642337
5Huntingtons disease_Homo sapiens_hsa050163.08897816
6Alzheimers disease_Homo sapiens_hsa050103.01743294
7Protein export_Homo sapiens_hsa030602.96944251
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.74114705
9RNA polymerase_Homo sapiens_hsa030202.68551922
10Cardiac muscle contraction_Homo sapiens_hsa042602.64321385
11Homologous recombination_Homo sapiens_hsa034401.78911559
12Mismatch repair_Homo sapiens_hsa034301.67845058
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61933806
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46048052
15Basal transcription factors_Homo sapiens_hsa030221.45707197
16Spliceosome_Homo sapiens_hsa030401.37947741
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36732609
18RNA degradation_Homo sapiens_hsa030181.35572635
19Propanoate metabolism_Homo sapiens_hsa006401.32980028
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.28572375
21DNA replication_Homo sapiens_hsa030301.28555852
22Fanconi anemia pathway_Homo sapiens_hsa034601.26655457
23Nucleotide excision repair_Homo sapiens_hsa034201.26367840
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25931692
25Folate biosynthesis_Homo sapiens_hsa007901.24543533
26Pyrimidine metabolism_Homo sapiens_hsa002401.20904055
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17545523
28Butanoate metabolism_Homo sapiens_hsa006501.11154175
29Glutathione metabolism_Homo sapiens_hsa004801.09760558
30Purine metabolism_Homo sapiens_hsa002301.09638235
31Phototransduction_Homo sapiens_hsa047441.08509081
32Chemical carcinogenesis_Homo sapiens_hsa052041.06656620
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05613945
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04797655
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00274352
36Nitrogen metabolism_Homo sapiens_hsa009100.98685150
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98344170
38Pyruvate metabolism_Homo sapiens_hsa006200.93371062
39Peroxisome_Homo sapiens_hsa041460.92456570
40Tryptophan metabolism_Homo sapiens_hsa003800.91282250
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91170582
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90371337
43One carbon pool by folate_Homo sapiens_hsa006700.87927050
44Base excision repair_Homo sapiens_hsa034100.87177630
45RNA transport_Homo sapiens_hsa030130.85537718
46Metabolic pathways_Homo sapiens_hsa011000.82345352
47Collecting duct acid secretion_Homo sapiens_hsa049660.81665379
48Fatty acid elongation_Homo sapiens_hsa000620.79529016
49Regulation of autophagy_Homo sapiens_hsa041400.75728483
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74123936
51Sulfur relay system_Homo sapiens_hsa041220.71129837
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70879278
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70531537
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66959934
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66464391
56Caffeine metabolism_Homo sapiens_hsa002320.65879207
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.65147612
58Linoleic acid metabolism_Homo sapiens_hsa005910.64941880
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62655319
60beta-Alanine metabolism_Homo sapiens_hsa004100.61813491
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.61174772
62Retinol metabolism_Homo sapiens_hsa008300.61011740
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.60349346
64Nicotine addiction_Homo sapiens_hsa050330.59801338
65Tyrosine metabolism_Homo sapiens_hsa003500.59016395
66Olfactory transduction_Homo sapiens_hsa047400.58090908
67Systemic lupus erythematosus_Homo sapiens_hsa053220.57383415
68Selenocompound metabolism_Homo sapiens_hsa004500.53732951
69Mineral absorption_Homo sapiens_hsa049780.53238868
70Sulfur metabolism_Homo sapiens_hsa009200.51439459
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49690987
72Vitamin digestion and absorption_Homo sapiens_hsa049770.48993386
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46467678
74Non-homologous end-joining_Homo sapiens_hsa034500.45464071
75Fatty acid degradation_Homo sapiens_hsa000710.43375033
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41388313
77Arachidonic acid metabolism_Homo sapiens_hsa005900.40898435
78Taste transduction_Homo sapiens_hsa047420.40493548
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40489651
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.40060794
81Asthma_Homo sapiens_hsa053100.38350744
82Circadian rhythm_Homo sapiens_hsa047100.37530844
83Hedgehog signaling pathway_Homo sapiens_hsa043400.34848708
84Arginine and proline metabolism_Homo sapiens_hsa003300.33336100
85Basal cell carcinoma_Homo sapiens_hsa052170.32521930
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32101602
87Phenylalanine metabolism_Homo sapiens_hsa003600.31784191
88Steroid biosynthesis_Homo sapiens_hsa001000.29887829
89Histidine metabolism_Homo sapiens_hsa003400.29842392
90Rheumatoid arthritis_Homo sapiens_hsa053230.24636735
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24384935
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23574213
93Type I diabetes mellitus_Homo sapiens_hsa049400.23508578
94Alcoholism_Homo sapiens_hsa050340.22885601
95Carbon metabolism_Homo sapiens_hsa012000.22442494
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.21715274
97Oocyte meiosis_Homo sapiens_hsa041140.21410701
98Fat digestion and absorption_Homo sapiens_hsa049750.19829687
99GABAergic synapse_Homo sapiens_hsa047270.19149147
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.18092546

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »