LINC00238

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spermatid development (GO:0007286)9.46309931
2sperm capacitation (GO:0048240)8.45155870
3multicellular organism reproduction (GO:0032504)8.23281774
4plasma membrane fusion (GO:0045026)8.22614164
5sperm-egg recognition (GO:0035036)7.99433671
6binding of sperm to zona pellucida (GO:0007339)7.84513548
7chromosome condensation (GO:0030261)7.50013622
8microtubule depolymerization (GO:0007019)7.41984731
9DNA packaging (GO:0006323)7.29527745
10response to pheromone (GO:0019236)7.22099300
11reproduction (GO:0000003)7.13054226
12axonemal dynein complex assembly (GO:0070286)6.99642570
13spermatid nucleus differentiation (GO:0007289)6.91995398
14calcium ion-dependent exocytosis (GO:0017156)6.74716123
15cell-cell recognition (GO:0009988)6.72927047
16phosphatidylethanolamine biosynthetic process (GO:0006646)6.67804663
17single strand break repair (GO:0000012)6.52755382
18negative regulation of inclusion body assembly (GO:0090084)6.50345514
19phosphatidylethanolamine metabolic process (GO:0046337)6.17459763
20protein polyglutamylation (GO:0018095)6.11449789
21motile cilium assembly (GO:0044458)6.11408751
22regulation of phosphoprotein phosphatase activity (GO:0043666)6.09933266
23rRNA methylation (GO:0031167)5.95327353
24microtubule polymerization or depolymerization (GO:0031109)5.94930629
25spermatogenesis (GO:0007283)5.81863799
26protein targeting to Golgi (GO:0000042)5.80370488
27male gamete generation (GO:0048232)5.79674419
28cilium or flagellum-dependent cell motility (GO:0001539)5.74039449
29single fertilization (GO:0007338)5.59673559
30establishment of protein localization to Golgi (GO:0072600)5.57751657
31microtubule severing (GO:0051013)5.38699212
32retrograde transport, vesicle recycling within Golgi (GO:0000301)5.37552709
33germ cell development (GO:0007281)5.32779861
34gamete generation (GO:0007276)5.32292780
35organic cation transport (GO:0015695)5.26875354
36sexual reproduction (GO:0019953)5.14673423
37epithelial cilium movement (GO:0003351)5.03549445
38male meiosis (GO:0007140)4.98714392
39centriole assembly (GO:0098534)4.98200535
40centriole replication (GO:0007099)4.96242852
41polyamine biosynthetic process (GO:0006596)4.94810397
42rRNA modification (GO:0000154)4.91647494
43regulation of cilium movement (GO:0003352)4.90957498
44positive regulation of Rab GTPase activity (GO:0032851)4.89773826
45regulation of Rab GTPase activity (GO:0032313)4.89773826
46cellular process involved in reproduction in multicellular organism (GO:0022412)4.86824143
47protein-DNA complex disassembly (GO:0032986)4.82979859
48nucleosome disassembly (GO:0006337)4.82979859
49cellular ketone body metabolic process (GO:0046950)4.78063119
50regulation of transcription involved in cell fate commitment (GO:0060850)4.73169320
51coenzyme catabolic process (GO:0009109)4.68596104
52regulation of inclusion body assembly (GO:0090083)4.61289674
53response to acidic pH (GO:0010447)4.59007088
54fertilization (GO:0009566)4.41841922
55cilium movement (GO:0003341)4.29134341
56multicellular organismal reproductive process (GO:0048609)4.28850378
57ketone body metabolic process (GO:1902224)4.20649001
58protein localization to Golgi apparatus (GO:0034067)4.09294388
59cell wall macromolecule metabolic process (GO:0044036)4.01101166
60cellular response to pH (GO:0071467)3.79915161
61cell wall macromolecule catabolic process (GO:0016998)3.78246631
62RNA destabilization (GO:0050779)3.75838361
63regulation of centriole replication (GO:0046599)3.69860744
64nucleus organization (GO:0006997)3.55880628
65histone H3-K9 demethylation (GO:0033169)3.55128323
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.55094266
67ventricular system development (GO:0021591)3.47321902
68chromatin silencing (GO:0006342)3.42718713
69histone exchange (GO:0043486)3.41032037
70seminiferous tubule development (GO:0072520)3.37084084
71regulation of microtubule-based movement (GO:0060632)3.36181341
72positive regulation of catecholamine secretion (GO:0033605)3.34368277
73cellular biogenic amine biosynthetic process (GO:0042401)3.27553190
74cell recognition (GO:0008037)3.25986091
75cranial nerve morphogenesis (GO:0021602)3.19057189
76amine biosynthetic process (GO:0009309)3.16317858
77musculoskeletal movement (GO:0050881)3.14818352
78multicellular organismal movement (GO:0050879)3.14818352
79regulation of ARF GTPase activity (GO:0032312)3.12768101
80antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12176822
81male sex determination (GO:0030238)3.11559907
82detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.08447263
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.08363604
84peptidyl-threonine dephosphorylation (GO:0035970)3.07568423
85multicellular organismal development (GO:0007275)2.99188046
86negative regulation of Rho protein signal transduction (GO:0035024)2.98749058
87mitochondrion degradation (GO:0000422)2.95615738
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.92650224
89membrane protein intracellular domain proteolysis (GO:0031293)2.89280224
90cerebral cortex neuron differentiation (GO:0021895)2.87455034
91protein depolymerization (GO:0051261)2.84159112
92receptor recycling (GO:0001881)2.83303240
93positive regulation of glycolytic process (GO:0045821)2.82330818
94Golgi to endosome transport (GO:0006895)2.72151682
95homeostasis of number of cells within a tissue (GO:0048873)2.71975354
96regulation of interleukin-13 production (GO:0032656)2.71206663
97DNA methylation involved in gamete generation (GO:0043046)2.70140611
98acrosome reaction (GO:0007340)12.7342790
99sperm motility (GO:0030317)12.3619203
100fusion of sperm to egg plasma membrane (GO:0007342)10.7645269

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.20793813
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.17399107
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.34138120
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82153545
5VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.81373145
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78824863
7EZH2_22144423_ChIP-Seq_EOC_Human2.66320637
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53732738
9POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.53732738
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.49548343
11IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.25730509
12CBP_20019798_ChIP-Seq_JUKART_Human2.25730509
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24004988
14FUS_26573619_Chip-Seq_HEK293_Human2.20746577
15NANOG_20526341_ChIP-Seq_ESCs_Human2.01587780
16RAC3_21632823_ChIP-Seq_H3396_Human1.94703191
17ERA_21632823_ChIP-Seq_H3396_Human1.91939783
18WDR5_24793694_ChIP-Seq_LNCAP_Human1.88969213
19ARNT_22903824_ChIP-Seq_MCF-7_Human1.88835172
20CTCF_27219007_Chip-Seq_Bcells_Human1.86860402
21ER_23166858_ChIP-Seq_MCF-7_Human1.80609691
22ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.79848741
23EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.78103967
24RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.76582688
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72948307
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70518073
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.70363491
28SMC4_20622854_ChIP-Seq_HELA_Human1.70075066
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.65157799
30AR_21572438_ChIP-Seq_LNCaP_Human1.64791787
31MYC_19829295_ChIP-Seq_ESCs_Human1.63621450
32OCT4_20526341_ChIP-Seq_ESCs_Human1.61936326
33EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.61758867
34ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52988609
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.49525268
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49403886
37ERG_20517297_ChIP-Seq_VCAP_Human1.48791690
38DROSHA_22980978_ChIP-Seq_HELA_Human1.48464458
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46644041
40TP53_18474530_ChIP-ChIP_U2OS_Human1.45628132
41CTCF_20526341_ChIP-Seq_ESCs_Human1.45412044
42BCL6_27268052_Chip-Seq_Bcells_Human1.45362204
43AR_25329375_ChIP-Seq_VCAP_Human1.45130879
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.44237977
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43873131
46PHF8_20622854_ChIP-Seq_HELA_Human1.41766782
47E2F1_20622854_ChIP-Seq_HELA_Human1.38806213
48P68_20966046_ChIP-Seq_HELA_Human1.37573750
49IGF1R_20145208_ChIP-Seq_DFB_Human1.37309190
50P300_19829295_ChIP-Seq_ESCs_Human1.34444193
51TBL1_22424771_ChIP-Seq_293T_Human1.33976984
52KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33914525
53P300_27268052_Chip-Seq_Bcells_Human1.32829072
54TDRD3_21172665_ChIP-Seq_MCF-7_Human1.32259880
55OCT1_27270436_Chip-Seq_PROSTATE_Human1.29665397
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29456059
57YY1_22570637_ChIP-Seq_MALME-3M_Human1.29321586
58TP63_22573176_ChIP-Seq_HFKS_Human1.27760163
59HNFA_21074721_ChIP-Seq_CACO-2_Human1.27756656
60LXR_22292898_ChIP-Seq_THP-1_Human1.27221065
61CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.26922230
62BCOR_27268052_Chip-Seq_Bcells_Human1.26576629
63P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.26234259
64TAF2_19829295_ChIP-Seq_ESCs_Human1.25673069
65SMAD3_21741376_ChIP-Seq_ESCs_Human1.24060412
66RUNX2_22187159_ChIP-Seq_PCA_Human1.23352083
67CBX2_22325352_ChIP-Seq_293T-Rex_Human1.22888803
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.22399464
69RBPJ_21746931_ChIP-Seq_IB4_Human1.21996088
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21442964
71AHR_22903824_ChIP-Seq_MCF-7_Human1.19327078
72SMAD4_21799915_ChIP-Seq_A2780_Human1.17887854
73NFYB_21822215_ChIP-Seq_K562_Human1.17879093
74ETV1_20927104_ChIP-Seq_GIST48_Human1.16621513
75GATA3_21878914_ChIP-Seq_MCF-7_Human1.16530184
76PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.16324995
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15748601
78NANOG_19829295_ChIP-Seq_ESCs_Human1.14889673
79SOX2_19829295_ChIP-Seq_ESCs_Human1.14889673
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12843239
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10443962
82SPI1_20517297_ChIP-Seq_HL60_Human1.10223207
83PHF8_20622853_ChIP-Seq_HELA_Human1.09933362
84GBX2_23144817_ChIP-Seq_PC3_Human1.09897001
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08495766
86ZNF274_21170338_ChIP-Seq_K562_Hela1.04588080
87STAT3_23295773_ChIP-Seq_U87_Human1.02608806
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.02346509
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.01560020
90CEBPB_22108803_ChIP-Seq_LS180_Human1.01234102
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.01082982
92GATA6_21074721_ChIP-Seq_CACO-2_Human1.00866146
93NFYA_21822215_ChIP-Seq_K562_Human1.00517881
94FOXH1_21741376_ChIP-Seq_ESCs_Human0.99781931
95SMAD4_21741376_ChIP-Seq_HESCs_Human0.99302785
96KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.99217546
97HOXB7_26014856_ChIP-Seq_BT474_Human0.98684059
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97234495
99GF1_26923725_Chip-Seq_HPCs_Mouse0.97219910
100TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94656945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.66725499
2MP0003878_abnormal_ear_physiology4.26460682
3MP0005377_hearing/vestibular/ear_phenot4.26460682
4MP0001929_abnormal_gametogenesis4.08059257
5MP0005670_abnormal_white_adipose3.94964567
6MP0002161_abnormal_fertility/fecundity2.57324227
7MP0002132_abnormal_respiratory_system2.47207230
8MP0008004_abnormal_stomach_pH2.37077099
9MP0000678_abnormal_parathyroid_gland2.17587885
10MP0001348_abnormal_lacrimal_gland2.14547051
11MP0003315_abnormal_perineum_morphology2.14184520
12MP0003718_maternal_effect2.12677367
13MP0005410_abnormal_fertilization13.0801134
14MP0002210_abnormal_sex_determination1.94154306
15MP0002822_catalepsy1.81023235
16MP0001145_abnormal_male_reproductive1.65142435
17MP0000653_abnormal_sex_gland1.54369569
18MP0002249_abnormal_larynx_morphology1.47528028
19MP0003646_muscle_fatigue1.47148710
20MP0001485_abnormal_pinna_reflex1.44767656
21MP0001905_abnormal_dopamine_level1.33990299
22MP0002160_abnormal_reproductive_system1.33748920
23MP0001984_abnormal_olfaction1.26695113
24MP0001486_abnormal_startle_reflex1.24692628
25MP0002127_abnormal_cardiovascular_syste1.22782716
26MP0005248_abnormal_Harderian_gland1.20232325
27MP0004859_abnormal_synaptic_plasticity1.18426547
28MP0009697_abnormal_copulation1.17990088
29MP0005423_abnormal_somatic_nervous1.17518510
30MP0002282_abnormal_trachea_morphology1.17118865
31MP0005395_other_phenotype1.14723352
32MP0005647_abnormal_sex_gland1.10833739
33MP0002234_abnormal_pharynx_morphology1.09799797
34MP0003879_abnormal_hair_cell1.08032881
35MP0005451_abnormal_body_composition1.07198900
36MP0003011_delayed_dark_adaptation1.03158093
37MP0002138_abnormal_hepatobiliary_system1.02873565
38MP0005379_endocrine/exocrine_gland_phen1.02594547
39MP0005360_urolithiasis1.02483041
40MP0001968_abnormal_touch/_nociception1.02051996
41MP0001963_abnormal_hearing_physiology0.97428654
42MP0000534_abnormal_ureter_morphology0.96057516
43MP0008995_early_reproductive_senescence0.92752938
44MP0000026_abnormal_inner_ear0.90323659
45MP0003045_fibrosis0.89858250
46MP0004742_abnormal_vestibular_system0.87772961
47MP0005499_abnormal_olfactory_system0.87080020
48MP0005394_taste/olfaction_phenotype0.87080020
49MP0010386_abnormal_urinary_bladder0.86772173
50MP0001765_abnormal_ion_homeostasis0.86753158
51MP0004085_abnormal_heartbeat0.85711329
52MP0002735_abnormal_chemical_nociception0.85565871
53MP0005253_abnormal_eye_physiology0.83633998
54MP0005310_abnormal_salivary_gland0.80634906
55MP0004510_myositis0.80120079
56MP0000049_abnormal_middle_ear0.75213609
57MP0005551_abnormal_eye_electrophysiolog0.75147779
58MP0010368_abnormal_lymphatic_system0.74883119
59MP0003136_yellow_coat_color0.73056628
60MP0002229_neurodegeneration0.73055141
61MP0000955_abnormal_spinal_cord0.70285648
62MP0000681_abnormal_thyroid_gland0.69811630
63MP0009115_abnormal_fat_cell0.69206163
64MP0002067_abnormal_sensory_capabilities0.67857682
65MP0009053_abnormal_anal_canal0.64589356
66MP0004484_altered_response_of0.64341561
67MP0003632_abnormal_nervous_system0.63871421
68MP0003936_abnormal_reproductive_system0.62814492
69MP0002272_abnormal_nervous_system0.62234739
70MP0001501_abnormal_sleep_pattern0.61068388
71MP0003631_nervous_system_phenotype0.60842964
72MP0004036_abnormal_muscle_relaxation0.60409362
73MP0004084_abnormal_cardiac_muscle0.60134452
74MP0000470_abnormal_stomach_morphology0.59756116
75MP0001664_abnormal_digestion0.58819281
76MP0002557_abnormal_social/conspecific_i0.58689075
77MP0001879_abnormal_lymphatic_vessel0.57330493
78MP0008569_lethality_at_weaning0.56719658
79MP0005167_abnormal_blood-brain_barrier0.56276795
80MP0001270_distended_abdomen0.54534280
81MP0002572_abnormal_emotion/affect_behav0.51791638
82MP0008877_abnormal_DNA_methylation0.51748531
83MP0001188_hyperpigmentation0.51147310
84MP0005389_reproductive_system_phenotype0.51061906
85MP0002168_other_aberrant_phenotype0.50382015
86MP0009745_abnormal_behavioral_response0.49417981
87MP0003635_abnormal_synaptic_transmissio0.46983822
88MP0000230_abnormal_systemic_arterial0.46516213
89MP0008789_abnormal_olfactory_epithelium0.46502668
90MP0001666_abnormal_nutrient_absorption0.46292467
91MP0001529_abnormal_vocalization0.45982785
92MP0005166_decreased_susceptibility_to0.43768237
93MP0003633_abnormal_nervous_system0.42628975
94MP0005391_vision/eye_phenotype0.42357353
95MP0003699_abnormal_female_reproductive0.40762778
96MP0002733_abnormal_thermal_nociception0.40432928
97MP0005083_abnormal_biliary_tract0.38969204
98MP0003077_abnormal_cell_cycle0.37805015
99MP0000538_abnormal_urinary_bladder0.37574910
100MP0005595_abnormal_vascular_smooth0.37481516

Predicted human phenotypes

RankGene SetZ-score
1Resting tremor (HP:0002322)6.72993626
2Severe visual impairment (HP:0001141)6.67978230
3Absent/shortened dynein arms (HP:0200106)6.59954248
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.59954248
5Abnormal respiratory motile cilium physiology (HP:0012261)5.51953532
6Abnormal ciliary motility (HP:0012262)5.49413517
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.42484676
8Infertility (HP:0000789)4.98466051
9Abnormal respiratory motile cilium morphology (HP:0005938)4.90304708
10Abnormal respiratory epithelium morphology (HP:0012253)4.90304708
11Tubulointerstitial nephritis (HP:0001970)4.84728522
12Bony spicule pigmentary retinopathy (HP:0007737)4.52680739
13Asymmetric septal hypertrophy (HP:0001670)4.50688564
14Postural instability (HP:0002172)4.40259545
15Attenuation of retinal blood vessels (HP:0007843)4.37582857
16Chronic hepatic failure (HP:0100626)4.21231597
17Nasal polyposis (HP:0100582)4.20077457
18Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.15666798
19Bell-shaped thorax (HP:0001591)4.11589905
20Abnormality of macular pigmentation (HP:0008002)3.80208728
21Male infertility (HP:0003251)3.77485466
22Abnormal rod and cone electroretinograms (HP:0008323)3.77293172
23Hyperkalemia (HP:0002153)3.63846432
24Abnormality of the nasal mucosa (HP:0000433)3.48906240
25Hypoplastic ischia (HP:0003175)3.37220603
26Facial shape deformation (HP:0011334)3.35737497
27Potter facies (HP:0002009)3.35737497
28Rhinitis (HP:0012384)3.32525859
29Abnormal sex determination (HP:0012244)3.28801915
30Sex reversal (HP:0012245)3.28801915
31Impulsivity (HP:0100710)3.23059894
32Aplasia/Hypoplasia of the earlobes (HP:0009906)3.08614961
33Abnormality of the ischium (HP:0003174)3.06209408
34Enlarged epiphyses (HP:0010580)2.92210957
35Hypoplasia of the thymus (HP:0000778)2.89462246
36Cone-rod dystrophy (HP:0000548)2.88259751
37Azoospermia (HP:0000027)2.86190781
38Abnormal spermatogenesis (HP:0008669)2.85040752
39Renal dysplasia (HP:0000110)2.74982115
40Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.65443245
41Hypoplasia of the uterus (HP:0000013)2.60774605
42Cerebellar dysplasia (HP:0007033)2.58495636
43Abnormal urine output (HP:0012590)2.54207999
44Occipital encephalocele (HP:0002085)2.46917015
45Hypoalphalipoproteinemia (HP:0003233)2.45062192
46Bronchiectasis (HP:0002110)2.42071251
47Chronic bronchitis (HP:0004469)2.41016587
48Flattened epiphyses (HP:0003071)2.36604483
49Polydipsia (HP:0001959)2.36274957
50Abnormal drinking behavior (HP:0030082)2.36274957
51Abnormality of dental color (HP:0011073)2.36221621
52Congenital sensorineural hearing impairment (HP:0008527)2.36181584
53Nephronophthisis (HP:0000090)2.35848726
54Progressive sensorineural hearing impairment (HP:0000408)2.32564890
55Colitis (HP:0002583)2.24988787
56Sensory axonal neuropathy (HP:0003390)2.24806855
57Abnormality of the aortic arch (HP:0012303)2.23449320
58Gonadal dysgenesis (HP:0000133)2.22561548
59Progressive cerebellar ataxia (HP:0002073)2.22311283
60Generalized aminoaciduria (HP:0002909)2.21797910
61Epiphyseal dysplasia (HP:0002656)2.20326342
62Truncal obesity (HP:0001956)2.19335616
63Tubulointerstitial abnormality (HP:0001969)2.17519599
64Double outlet right ventricle (HP:0001719)2.16631633
65Congenital malformation of the right heart (HP:0011723)2.16631633
66Renovascular hypertension (HP:0100817)2.15758609
67Abnormality of renal excretion (HP:0011036)2.15451219
68Portal hypertension (HP:0001409)2.13251113
69Type II lissencephaly (HP:0007260)2.12366458
70Male pseudohermaphroditism (HP:0000037)2.11956848
71Abnormality of the columella (HP:0009929)2.11213026
72Abnormality of potassium homeostasis (HP:0011042)2.07415412
73Optic nerve hypoplasia (HP:0000609)2.05295727
74Atonic seizures (HP:0010819)2.04906837
75Polyuria (HP:0000103)2.04079517
76Menstrual irregularities (HP:0000858)2.03854530
77Anterior segment dysgenesis (HP:0007700)2.03756504
78Abnormality of the hepatic vasculature (HP:0006707)2.01323181
79Retinal dysplasia (HP:0007973)2.00567590
80Abnormality of the costochondral junction (HP:0000919)1.99741135
81Recurrent corneal erosions (HP:0000495)1.98457670
82Stage 5 chronic kidney disease (HP:0003774)1.97096965
83Abnormality of the renal medulla (HP:0100957)1.95146127
84Aplasia/hypoplasia of the uterus (HP:0008684)1.94109980
85Unilateral renal agenesis (HP:0000122)1.93124640
86Germ cell neoplasia (HP:0100728)1.92768358
87Insulin-resistant diabetes mellitus (HP:0000831)1.92532074
88Hypophosphatemic rickets (HP:0004912)1.89117123
89Widely patent fontanelles and sutures (HP:0004492)1.87091988
90Amelogenesis imperfecta (HP:0000705)1.86715610
91Retinal atrophy (HP:0001105)1.84230111
92Photophobia (HP:0000613)1.79054227
93Bulbous nose (HP:0000414)1.78500841
94Absent epiphyses (HP:0010577)1.78350396
95Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78350396
96Recurrent pneumonia (HP:0006532)1.73621016
97Protuberant abdomen (HP:0001538)1.71515480
98Mixed hearing impairment (HP:0000410)1.68358160
99Type II diabetes mellitus (HP:0005978)1.64648719
100Increased purine levels (HP:0004368)1.64506856

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.93338816
2PINK16.48905687
3TESK14.66939534
4DDR24.25158245
5STK383.50810408
6MARK33.14585815
7INSRR2.85474341
8STK38L2.69923894
9MAPK152.46505948
10PLK22.41187391
11MAP4K22.26066256
12PNCK2.18245309
13PRKD32.12902087
14BRD42.09541138
15MST1R2.05619670
16ZAK1.96812741
17TLK11.83361385
18CAMK1G1.80517477
19LATS11.55892544
20MYLK1.47472548
21PDPK11.40693470
22NEK21.35114078
23RPS6KA51.29083654
24PDK11.25567133
25PIK3CG1.19609314
26WNK11.14877709
27PTK2B1.07715840
28LATS21.07442784
29MAP3K91.06502122
30CDK31.03475013
31CDK120.99625560
32CDK70.98408746
33SGK2230.93417982
34SGK4940.93417982
35NEK60.89503599
36AKT30.85323041
37PRKG20.84524237
38DYRK1B0.81670711
39MAP2K70.78598992
40BMPR1B0.77180982
41KSR20.74792102
42ROCK10.70625568
43BRAF0.69940321
44ARAF0.69214672
45PRKG10.69092158
46CAMK1D0.63068284
47MAP3K10.60981568
48RPS6KA10.60916863
49FRK0.60422314
50CAMK10.56791546
51RPS6KA20.55905490
52DYRK30.50614933
53OBSCN0.50428422
54PRKCQ0.47950256
55TYRO30.41255446
56SIK20.40606184
57TIE10.39024737
58MAP3K20.38698394
59MAPK10.37487654
60MTOR0.37408529
61STK390.37195116
62MAP3K80.36994793
63GSK3B0.34941666
64PKN10.34627262
65CDK140.33959051
66PRKAA20.32793593
67VRK10.32576763
68UHMK10.30079649
69WNK40.29603411
70CDK20.28912838
71CDK10.27852680
72SGK20.25710099
73CAMK40.25693960
74DYRK20.25682888
75MUSK0.24727016
76PAK10.24590529
77MET0.24325436
78RPS6KC10.21265768
79RPS6KL10.21265768
80MAP3K130.21057074
81MAPK80.20780938
82PAK20.20282106
83SGK10.19776964
84FGFR20.19356327
85CDK50.18747884
86MAP3K110.18458577
87TNIK0.18433194
88PRKCB0.18036231
89RPS6KA60.17178247
90MINK10.16399132
91CDK40.15555805
92PRKCG0.15116634
93CHEK10.14489037
94ADRBK20.14235100
95MAP2K20.13047566
96RPS6KA30.12275773
97CSNK1A1L0.11918649
98ATM0.10648851
99MAPK110.10346193
100MAPK100.09880455

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.18406859
2Fatty acid biosynthesis_Homo sapiens_hsa000615.48122474
3Olfactory transduction_Homo sapiens_hsa047403.91067999
4Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.07742410
5Butanoate metabolism_Homo sapiens_hsa006502.79099812
6Gap junction_Homo sapiens_hsa045402.51768504
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.31836105
8Hedgehog signaling pathway_Homo sapiens_hsa043402.27469050
9Arginine biosynthesis_Homo sapiens_hsa002201.99532067
10Dorso-ventral axis formation_Homo sapiens_hsa043201.96562341
11Glycerophospholipid metabolism_Homo sapiens_hsa005641.84899140
12Nitrogen metabolism_Homo sapiens_hsa009101.72497514
13Fatty acid degradation_Homo sapiens_hsa000711.69285740
14Taste transduction_Homo sapiens_hsa047421.69136786
15Phenylalanine metabolism_Homo sapiens_hsa003601.62066152
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51449898
17Systemic lupus erythematosus_Homo sapiens_hsa053221.48366328
18Alcoholism_Homo sapiens_hsa050341.37159806
19Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33580274
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.27222708
21Fatty acid metabolism_Homo sapiens_hsa012121.24777093
22Phagosome_Homo sapiens_hsa041451.18716974
23PPAR signaling pathway_Homo sapiens_hsa033201.15506644
24Type II diabetes mellitus_Homo sapiens_hsa049301.11473147
25RNA transport_Homo sapiens_hsa030131.11206302
26Oocyte meiosis_Homo sapiens_hsa041141.09787907
27Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04566079
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02430344
29Apoptosis_Homo sapiens_hsa042100.99982467
30Propanoate metabolism_Homo sapiens_hsa006400.95822356
31Synaptic vesicle cycle_Homo sapiens_hsa047210.92071303
32Arginine and proline metabolism_Homo sapiens_hsa003300.89957045
33Calcium signaling pathway_Homo sapiens_hsa040200.88850433
34Vascular smooth muscle contraction_Homo sapiens_hsa042700.86913019
35Adipocytokine signaling pathway_Homo sapiens_hsa049200.86656894
36Renin secretion_Homo sapiens_hsa049240.85999285
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85134515
38Phototransduction_Homo sapiens_hsa047440.84598693
39Salivary secretion_Homo sapiens_hsa049700.83417280
40Protein digestion and absorption_Homo sapiens_hsa049740.82739478
41Type I diabetes mellitus_Homo sapiens_hsa049400.82095758
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80877429
43Tyrosine metabolism_Homo sapiens_hsa003500.78978921
44Circadian entrainment_Homo sapiens_hsa047130.78691312
45Gastric acid secretion_Homo sapiens_hsa049710.76851388
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.76523821
47Selenocompound metabolism_Homo sapiens_hsa004500.74225067
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72460852
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71748414
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70921795
51Endocytosis_Homo sapiens_hsa041440.69658663
52Autoimmune thyroid disease_Homo sapiens_hsa053200.67957907
53Allograft rejection_Homo sapiens_hsa053300.67242070
54Inositol phosphate metabolism_Homo sapiens_hsa005620.65233105
55cAMP signaling pathway_Homo sapiens_hsa040240.64572489
56Estrogen signaling pathway_Homo sapiens_hsa049150.62501268
57Graft-versus-host disease_Homo sapiens_hsa053320.62091841
58Morphine addiction_Homo sapiens_hsa050320.61619597
59Purine metabolism_Homo sapiens_hsa002300.60104239
60Antigen processing and presentation_Homo sapiens_hsa046120.59966313
61ABC transporters_Homo sapiens_hsa020100.59598854
62Oxytocin signaling pathway_Homo sapiens_hsa049210.59455326
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58020924
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57726349
65Chemical carcinogenesis_Homo sapiens_hsa052040.55337472
66Glycerolipid metabolism_Homo sapiens_hsa005610.54980980
67Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54095746
68Basal transcription factors_Homo sapiens_hsa030220.53741248
69Retinol metabolism_Homo sapiens_hsa008300.53586869
70Nicotine addiction_Homo sapiens_hsa050330.48897993
71mRNA surveillance pathway_Homo sapiens_hsa030150.47975620
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47569624
73Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47287927
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46304454
75Glutamatergic synapse_Homo sapiens_hsa047240.43513301
76Glucagon signaling pathway_Homo sapiens_hsa049220.42879661
77Viral myocarditis_Homo sapiens_hsa054160.42255065
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41599000
79Influenza A_Homo sapiens_hsa051640.41269539
80Renin-angiotensin system_Homo sapiens_hsa046140.39926845
81MAPK signaling pathway_Homo sapiens_hsa040100.39838207
82Tight junction_Homo sapiens_hsa045300.39533857
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39369305
84Pyruvate metabolism_Homo sapiens_hsa006200.39053464
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37120688
86Bile secretion_Homo sapiens_hsa049760.36656782
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36005142
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.35819965
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35710075
90Fanconi anemia pathway_Homo sapiens_hsa034600.35335558
91Cholinergic synapse_Homo sapiens_hsa047250.35107419
92GABAergic synapse_Homo sapiens_hsa047270.34870912
93Fat digestion and absorption_Homo sapiens_hsa049750.33512175
94Circadian rhythm_Homo sapiens_hsa047100.32197423
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31307963
96Long-term potentiation_Homo sapiens_hsa047200.30738089
97VEGF signaling pathway_Homo sapiens_hsa043700.29509249
98ECM-receptor interaction_Homo sapiens_hsa045120.28905901
99Glutathione metabolism_Homo sapiens_hsa004800.27868114
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27235798

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