LINC00176

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein kinase C signaling (GO:0090037)5.31682201
2cellular response to interleukin-15 (GO:0071350)5.18732318
3CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.04416870
4response to interleukin-15 (GO:0070672)4.89391708
5GDP-mannose metabolic process (GO:0019673)4.43895557
6positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.39368211
7B cell receptor signaling pathway (GO:0050853)4.26084993
8protein carboxylation (GO:0018214)4.19510098
9peptidyl-glutamic acid carboxylation (GO:0017187)4.19510098
10B cell homeostasis (GO:0001782)4.18227606
11thymic T cell selection (GO:0045061)3.93715159
12negative regulation of cell killing (GO:0031342)3.89062803
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.89062803
14positive thymic T cell selection (GO:0045059)3.84272377
15very-low-density lipoprotein particle assembly (GO:0034379)3.82994781
16proline biosynthetic process (GO:0006561)3.82868006
17regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.80048900
18T-helper 1 type immune response (GO:0042088)3.79814023
19regulation of cholesterol homeostasis (GO:2000188)3.79156775
20negative thymic T cell selection (GO:0045060)3.76962184
21proline metabolic process (GO:0006560)3.70855454
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.70779614
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.70253107
24positive regulation of humoral immune response (GO:0002922)3.68504404
25negative regulation of myeloid cell apoptotic process (GO:0033033)3.67962837
26positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.67334851
27plasma lipoprotein particle assembly (GO:0034377)3.65949129
28response to muramyl dipeptide (GO:0032495)3.64109659
29positive regulation of gamma-delta T cell activation (GO:0046645)3.63028626
30T cell lineage commitment (GO:0002360)3.62345026
31myeloid dendritic cell differentiation (GO:0043011)3.60006936
32negative T cell selection (GO:0043383)3.57750164
33regulation of B cell receptor signaling pathway (GO:0050855)3.52478759
34antigen processing and presentation of endogenous antigen (GO:0019883)3.48968432
35low-density lipoprotein particle clearance (GO:0034383)3.47697466
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.34802388
37B cell proliferation (GO:0042100)3.25872743
38regulation of interferon-gamma biosynthetic process (GO:0045072)3.24201401
39intestinal cholesterol absorption (GO:0030299)3.18145831
40DNA strand renaturation (GO:0000733)3.17366256
41activation of MAPKKK activity (GO:0000185)3.14179251
42immunoglobulin mediated immune response (GO:0016064)3.13520022
43protein-lipid complex assembly (GO:0065005)3.10395109
44interferon-gamma production (GO:0032609)3.10137480
45T cell costimulation (GO:0031295)3.07887148
46myeloid dendritic cell activation (GO:0001773)3.06887321
47mannose metabolic process (GO:0006013)3.06383045
48plasma lipoprotein particle clearance (GO:0034381)3.04213557
49lymphocyte costimulation (GO:0031294)3.02323281
50regulation of type I interferon-mediated signaling pathway (GO:0060338)3.01973020
51tolerance induction (GO:0002507)3.00255240
52cellular response to ATP (GO:0071318)3.00205948
53negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.00085509
54regulation of T cell mediated cytotoxicity (GO:0001914)2.99614858
55regulation of gamma-delta T cell activation (GO:0046643)2.96992336
56regulation of defense response to virus by host (GO:0050691)2.95004868
57diacylglycerol metabolic process (GO:0046339)2.94922297
58plasma lipoprotein particle organization (GO:0071827)2.94033357
59high-density lipoprotein particle remodeling (GO:0034375)2.93372095
60germinal center formation (GO:0002467)2.93350837
61positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92405747
62phosphate ion homeostasis (GO:0055062)2.91858946
63trivalent inorganic anion homeostasis (GO:0072506)2.91858946
64regulation of protein kinase C signaling (GO:0090036)2.90072613
65positive regulation of defense response to virus by host (GO:0002230)2.89964897
66cellular response to virus (GO:0098586)2.89785512
67response to type I interferon (GO:0034340)2.86847054
68negative regulation of viral release from host cell (GO:1902187)2.85127364
69lung epithelium development (GO:0060428)2.84969163
70low-density lipoprotein particle remodeling (GO:0034374)2.84548246
71negative regulation of T cell mediated immunity (GO:0002710)2.83983203
72cellular zinc ion homeostasis (GO:0006882)2.83114562
73plasma lipoprotein particle remodeling (GO:0034369)2.82825551
74protein-lipid complex remodeling (GO:0034368)2.82825551
75macromolecular complex remodeling (GO:0034367)2.82825551
76intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.82323928
77tumor necrosis factor-mediated signaling pathway (GO:0033209)2.81701159
78positive regulation of B cell proliferation (GO:0030890)2.81290016
79regulation of B cell proliferation (GO:0030888)2.79305708
80G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77471875
81positive T cell selection (GO:0043368)2.77449533
82regulation of monocyte differentiation (GO:0045655)2.76570274
83T cell migration (GO:0072678)2.76317026
84oligosaccharide catabolic process (GO:0009313)2.76073747
85reverse cholesterol transport (GO:0043691)2.75267744
86negative regulation of fibrinolysis (GO:0051918)2.73193257
87lymphocyte homeostasis (GO:0002260)2.71700833
88regulation of alpha-beta T cell proliferation (GO:0046640)2.70079486
89purine ribonucleotide transport (GO:0015868)2.68450411
90protein-lipid complex subunit organization (GO:0071825)2.68089696
91T cell selection (GO:0045058)2.66104461
92cellular response to type I interferon (GO:0071357)2.65805996
93type I interferon signaling pathway (GO:0060337)2.65805996
94production of molecular mediator of immune response (GO:0002440)2.64737224
95DNA deamination (GO:0045006)2.60792724
96negative regulation of innate immune response (GO:0045824)2.60052111
97histone H3-K36 demethylation (GO:0070544)2.58115833
98cytidine metabolic process (GO:0046087)2.55731192
99cytidine catabolic process (GO:0006216)2.55731192
100cytidine deamination (GO:0009972)2.55731192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.63662188
2VDR_21846776_ChIP-Seq_THP-1_Human3.59796508
3TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse3.35333149
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.33186608
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.90211245
6LXR_22292898_ChIP-Seq_THP-1_Human2.83143369
7MAF_26560356_Chip-Seq_TH1_Human2.50587990
8MAF_26560356_Chip-Seq_TH2_Human2.37820161
9P68_20966046_ChIP-Seq_HELA_Human2.32171093
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.24160962
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16622397
12E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.14393563
13TCF7_22412390_ChIP-Seq_EML_Mouse2.06037563
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03658755
15UTX_26944678_Chip-Seq_JUKART_Human1.97043963
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.94936452
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.92218553
18ZNF263_19887448_ChIP-Seq_K562_Human1.91442418
19KDM2B_26808549_Chip-Seq_DND41_Human1.88627475
20CIITA_25753668_ChIP-Seq_RAJI_Human1.88109679
21VDR_24763502_ChIP-Seq_THP-1_Human1.87519870
22BCL6_27268052_Chip-Seq_Bcells_Human1.85247322
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.82940715
24BCOR_27268052_Chip-Seq_Bcells_Human1.82283774
25RACK7_27058665_Chip-Seq_MCF-7_Human1.80289587
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76337737
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.73216373
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71151012
29STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69806590
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.64098053
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60394872
32SMC4_20622854_ChIP-Seq_HELA_Human1.58717723
33E2F1_20622854_ChIP-Seq_HELA_Human1.57237925
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.56709549
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55226371
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50877931
37CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50328397
38TP53_22127205_ChIP-Seq_IMR90_Human1.48838899
39TP63_17297297_ChIP-ChIP_HaCaT_Human1.48728428
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47348044
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46432066
42PHF8_20622854_ChIP-Seq_HELA_Human1.46112409
43RARB_24833708_ChIP-Seq_LIVER_Mouse1.45969418
44SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44685018
45ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.42824014
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42796168
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42558231
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.39008503
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.38968199
50MYB_26560356_Chip-Seq_TH1_Human1.38509740
51HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38320030
52RARA_24833708_ChIP-Seq_LIVER_Mouse1.37541077
53XRN2_22483619_ChIP-Seq_HELA_Human1.36520000
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.34865162
55MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.34533393
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.30591363
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30325222
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30075763
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29891509
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.29701789
61CREB1_26743006_Chip-Seq_LNCaP_Human1.25694329
62PU.1_20513432_ChIP-Seq_Bcells_Mouse1.25463240
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24446903
64RXR_22158963_ChIP-Seq_LIVER_Mouse1.23744151
65RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23193701
66EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23190525
67SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22487988
68KDM2B_26808549_Chip-Seq_JURKAT_Human1.21730868
69CTCF_21964334_ChIP-Seq_BJAB-B_Human1.19837014
70PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19004257
71CTCF_27219007_Chip-Seq_Bcells_Human1.18864204
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.18245204
73NCOR1_26117541_ChIP-Seq_K562_Human1.18131172
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17831352
75CTCF_21964334_Chip-Seq_Bcells_Human1.16736348
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16710539
77RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15373420
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.14961514
79ETS1_21867929_ChIP-Seq_TH2_Mouse1.14883549
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13867907
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13447100
82FOXP1_21924763_ChIP-Seq_HESCs_Human1.12893289
83ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12449002
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.11089720
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10885717
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09662209
87DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08990781
88CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08075477
89RUNX1_27514584_Chip-Seq_MCF-7_Human1.07215419
90MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06983640
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06674001
92EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05651631
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05627513
94SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05596933
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.05437744
96ATF3_27146783_Chip-Seq_COLON_Human1.05188842
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04399810
98IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04260687
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02547537
100P300_27268052_Chip-Seq_Bcells_Human1.02209726

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000685_abnormal_immune_system4.65949629
2MP0005671_abnormal_response_to3.97513917
3MP0005645_abnormal_hypothalamus_physiol3.62674649
4MP0003763_abnormal_thymus_physiology3.05478597
5MP0004381_abnormal_hair_follicle3.03439681
6MP0001800_abnormal_humoral_immune2.68071673
7MP0005387_immune_system_phenotype2.60104116
8MP0001790_abnormal_immune_system2.60104116
9MP0005360_urolithiasis2.58501604
10MP0003136_yellow_coat_color2.52605562
11MP0005174_abnormal_tail_pigmentation2.38935848
12MP0003172_abnormal_lysosome_physiology2.26977237
13MP0005000_abnormal_immune_tolerance2.26111113
14MP0003436_decreased_susceptibility_to2.25359375
15MP0001986_abnormal_taste_sensitivity2.22573579
16MP0001835_abnormal_antigen_presentation2.15002625
17MP0005423_abnormal_somatic_nervous2.10996089
18MP0002166_altered_tumor_susceptibility2.05778474
19MP0002723_abnormal_immune_serum2.04866801
20MP0002933_joint_inflammation1.98197156
21MP0009333_abnormal_splenocyte_physiolog1.96074192
22MP0002398_abnormal_bone_marrow1.94623725
23MP0005409_darkened_coat_color1.86373889
24MP0005076_abnormal_cell_differentiation1.84789186
25MP0000013_abnormal_adipose_tissue1.83871482
26MP0000003_abnormal_adipose_tissue1.83759110
27MP0005171_absent_coat_pigmentation1.81726006
28MP0002452_abnormal_antigen_presenting1.78383984
29MP0002420_abnormal_adaptive_immunity1.78055178
30MP0001819_abnormal_immune_cell1.75638076
31MP0003111_abnormal_nucleus_morphology1.68633553
32MP0000716_abnormal_immune_system1.68460437
33MP0000703_abnormal_thymus_morphology1.68101138
34MP0001873_stomach_inflammation1.65395982
35MP0005025_abnormal_response_to1.62373390
36MP0001348_abnormal_lacrimal_gland1.61717409
37MP0005451_abnormal_body_composition1.59583143
38MP0004947_skin_inflammation1.59031046
39MP0002429_abnormal_blood_cell1.53686874
40MP0002722_abnormal_immune_system1.50055065
41MP0008875_abnormal_xenobiotic_pharmacok1.48424667
42MP0002089_abnormal_postnatal_growth/wei1.48117230
43MP0000015_abnormal_ear_pigmentation1.45811441
44MP0000371_diluted_coat_color1.43870693
45MP0000689_abnormal_spleen_morphology1.42636867
46MP0009840_abnormal_foam_cell1.42353544
47MP0002139_abnormal_hepatobiliary_system1.33880989
48MP0003183_abnormal_peptide_metabolism1.32553401
49MP0001188_hyperpigmentation1.32377188
50MP0005167_abnormal_blood-brain_barrier1.28090008
51MP0010329_abnormal_lipoprotein_level1.27716864
52MP0003879_abnormal_hair_cell1.27411013
53MP0003303_peritoneal_inflammation1.27344368
54MP0002160_abnormal_reproductive_system1.26087940
55MP0002006_tumorigenesis1.22865609
56MP0005058_abnormal_lysosome_morphology1.21822572
57MP0001661_extended_life_span1.21020142
58MP0005365_abnormal_bile_salt1.18422454
59MP0010155_abnormal_intestine_physiology1.16983773
60MP0001270_distended_abdomen1.16590347
61MP0002138_abnormal_hepatobiliary_system1.13227704
62MP0000609_abnormal_liver_physiology1.10090311
63MP0002405_respiratory_system_inflammati1.09551445
64MP0001502_abnormal_circadian_rhythm1.08497091
65MP0009785_altered_susceptibility_to1.05039858
66MP0002019_abnormal_tumor_incidence0.99330323
67MP0010094_abnormal_chromosome_stability0.99290827
68MP0001845_abnormal_inflammatory_respons0.98454831
69MP0002419_abnormal_innate_immunity0.97477169
70MP0005220_abnormal_exocrine_pancreas0.89267728
71MP0005083_abnormal_biliary_tract0.84632329
72MP0005332_abnormal_amino_acid0.84397683
73MP0002136_abnormal_kidney_physiology0.83859425
74MP0002075_abnormal_coat/hair_pigmentati0.80767054
75MP0003045_fibrosis0.78931743
76MP0005464_abnormal_platelet_physiology0.78811243
77MP0002998_abnormal_bone_remodeling0.76705608
78MP0008469_abnormal_protein_level0.75811237
79MP0005499_abnormal_olfactory_system0.75649731
80MP0005394_taste/olfaction_phenotype0.75649731
81MP0002118_abnormal_lipid_homeostasis0.74945774
82MP0005084_abnormal_gallbladder_morpholo0.74255177
83MP0003866_abnormal_defecation0.73844826
84MP0009046_muscle_twitch0.72770181
85MP0005623_abnormal_meninges_morphology0.72288531
86MP0005310_abnormal_salivary_gland0.71539835
87MP0001756_abnormal_urination0.71420517
88MP0005375_adipose_tissue_phenotype0.71381995
89MP0009643_abnormal_urine_homeostasis0.70575613
90MP0003077_abnormal_cell_cycle0.68898245
91MP0001765_abnormal_ion_homeostasis0.68238442
92MP0001919_abnormal_reproductive_system0.67252575
93MP0003656_abnormal_erythrocyte_physiolo0.67143569
94MP0005330_cardiomyopathy0.66909845
95MP0002148_abnormal_hypersensitivity_rea0.66557853
96MP0005389_reproductive_system_phenotype0.65098808
97MP0001666_abnormal_nutrient_absorption0.63676305
98MP0003453_abnormal_keratinocyte_physiol0.62264612
99MP0000858_altered_metastatic_potential0.61431207
100MP0000747_muscle_weakness0.60540633

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)5.42755805
2Hemorrhage of the eye (HP:0011885)4.64444830
3Joint hemorrhage (HP:0005261)4.60765721
4Recurrent sinusitis (HP:0011108)4.22813586
5IgA deficiency (HP:0002720)4.14041195
6Deep venous thrombosis (HP:0002625)4.09178098
7Squamous cell carcinoma (HP:0002860)4.00584287
8Prolonged partial thromboplastin time (HP:0003645)3.91113249
9Emphysema (HP:0002097)3.73494997
10Poikiloderma (HP:0001029)3.64320955
11Vaginal fistula (HP:0004320)3.50222756
12Conical tooth (HP:0000698)3.47642314
13IgG deficiency (HP:0004315)3.37854110
14Basal cell carcinoma (HP:0002671)3.26995128
15Small epiphyses (HP:0010585)3.19170841
16Recurrent bronchitis (HP:0002837)3.18888854
17Facial hemangioma (HP:0000329)3.17642668
18Vasculitis (HP:0002633)3.16872239
19Lymphopenia (HP:0001888)3.09728207
20Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.09696474
21Agammaglobulinemia (HP:0004432)3.03377225
22IgM deficiency (HP:0002850)3.02704104
23Intestinal fistula (HP:0100819)2.99623986
24Colitis (HP:0002583)2.95011475
25Abnormality of cells of the lymphoid lineage (HP:0012140)2.93759355
26Meningitis (HP:0001287)2.92353490
27Abnormality of the intrinsic pathway (HP:0010989)2.87019403
28Rectovaginal fistula (HP:0000143)2.81531843
29Rectal fistula (HP:0100590)2.81531843
30Capillary hemangiomas (HP:0005306)2.79507033
31Annular pancreas (HP:0001734)2.56454463
32Ulnar bowing (HP:0003031)2.56311165
33Testicular atrophy (HP:0000029)2.53146874
34Restrictive lung disease (HP:0002091)2.51807453
35Thin bony cortex (HP:0002753)2.48371428
36Abnormality of T cell physiology (HP:0011840)2.40122392
37Optic neuritis (HP:0100653)2.36668845
38Retrobulbar optic neuritis (HP:0100654)2.36668845
39Pustule (HP:0200039)2.36264590
40Abnormality of the common coagulation pathway (HP:0010990)2.34301142
41Flattened epiphyses (HP:0003071)2.29574210
42Panhypogammaglobulinemia (HP:0003139)2.27364807
43Recurrent fungal infections (HP:0002841)2.19998135
44Chronic diarrhea (HP:0002028)2.18291606
45Gastrointestinal infarctions (HP:0005244)2.14187428
46Mediastinal lymphadenopathy (HP:0100721)2.13852040
47Anteriorly placed anus (HP:0001545)2.12911472
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.12860024
49Abnormality of T cells (HP:0002843)2.11486574
50Hypobetalipoproteinemia (HP:0003563)2.08045663
51Gastrointestinal inflammation (HP:0004386)2.07296090
52Xanthomatosis (HP:0000991)2.06956728
53Short chin (HP:0000331)2.06326001
54Inflammation of the large intestine (HP:0002037)2.04539955
55Patellar aplasia (HP:0006443)2.04009711
56Hypophosphatemic rickets (HP:0004912)2.03761257
57Recurrent cutaneous fungal infections (HP:0011370)2.02409137
58Chronic mucocutaneous candidiasis (HP:0002728)2.02409137
59Recurrent otitis media (HP:0000403)2.02274122
60Severe combined immunodeficiency (HP:0004430)2.01549199
61Facial diplegia (HP:0001349)2.00232955
62Hyperacusis (HP:0010780)1.98834847
63Hypochromic anemia (HP:0001931)1.98636332
64Recurrent viral infections (HP:0004429)1.98122305
65Akinesia (HP:0002304)1.97607708
66Rib fusion (HP:0000902)1.94771953
67Pulmonary infiltrates (HP:0002113)1.93950405
68Abnormality of the pleura (HP:0002103)1.91999132
69B lymphocytopenia (HP:0010976)1.88794967
70Abnormality of the fingertips (HP:0001211)1.88083098
71Lymphoma (HP:0002665)1.87953090
72Orchitis (HP:0100796)1.86615758
73Abnormal delayed hypersensitivity skin test (HP:0002963)1.85817147
74Attenuation of retinal blood vessels (HP:0007843)1.82121292
75Leukopenia (HP:0001882)1.81432992
76Pigmentary retinal degeneration (HP:0001146)1.80283260
77Self-mutilation (HP:0000742)1.79915317
78Cellulitis (HP:0100658)1.78404053
79Abnormality of eosinophils (HP:0001879)1.77621407
80Aplasia/Hypoplasia of the patella (HP:0006498)1.76140137
81Mesangial abnormality (HP:0001966)1.73294204
82Recurrent pneumonia (HP:0006532)1.72106007
83Purpura (HP:0000979)1.69260546
84Easy fatigability (HP:0003388)1.69148685
85Nonimmune hydrops fetalis (HP:0001790)1.68916580
86Hypertensive crisis (HP:0100735)1.67341276
87Dry hair (HP:0011359)1.66108424
88Recurrent lower respiratory tract infections (HP:0002783)1.65276100
89Hypotrichosis (HP:0001006)1.64530654
90Epiphyseal dysplasia (HP:0002656)1.64146738
91Irregular epiphyses (HP:0010582)1.63560758
92Pulmonary embolism (HP:0002204)1.63242886
93Arterial thrombosis (HP:0004420)1.62562225
94Hypercholesterolemia (HP:0003124)1.62155705
95Myopathic facies (HP:0002058)1.62013545
96Absent epiphyses (HP:0010577)1.61063823
97Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.61063823
98Abnormality of male internal genitalia (HP:0000022)1.60739518
99Asymmetry of the thorax (HP:0001555)1.59961512
100Arthralgia (HP:0002829)1.59923986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.09633775
2TRIB33.78855086
3FGFR43.67917058
4SIK23.65031594
5MAP4K13.16775813
6MAP3K142.51878591
7CDK122.45209071
8SMG12.43232289
9ERN12.40951102
10EEF2K2.33353596
11ICK2.32910279
12WNK42.29631010
13SIK12.19577688
14TXK2.08393267
15MAPK152.06230344
16TBK12.05343355
17RIPK42.04947366
18ZAK1.96869426
19MAP3K131.92675772
20IKBKE1.82023526
21FGFR31.78491159
22MAPK111.59022634
23MARK31.54853795
24MAP3K101.44438285
25PRPF4B1.42271343
26GRK61.37089806
27IKBKB1.30753573
28SYK1.25016662
29KDR1.21567413
30TESK21.21162435
31TAOK31.18162229
32PDPK11.13743094
33BLK1.12325933
34PKN21.12097143
35IRAK41.11066401
36NEK21.07420903
37TYRO31.06139330
38MAPKAPK31.04276280
39VRK11.02444292
40MAP2K21.02429245
41JAK11.01557566
42CDC42BPA0.97918451
43CHUK0.97130060
44PDK10.94575088
45CSF1R0.93992762
46RPS6KA50.93305781
47BTK0.92567212
48MAP3K90.92102159
49CDK40.86946986
50PRKCQ0.86057411
51ARAF0.85570143
52MAPK120.84944387
53DAPK30.82737332
54WNK10.81353133
55NEK90.78954566
56KIT0.78503432
57SIK30.77110413
58DYRK1B0.76272796
59MATK0.76078434
60LYN0.69231448
61CSK0.68871894
62RET0.67454412
63PRKD20.66508511
64MAP2K60.63665489
65LCK0.61980879
66MARK20.60735616
67MUSK0.60636829
68MTOR0.59773690
69BRD40.57022416
70CDK70.56031604
71JAK30.55117646
72MELK0.50235898
73PIM20.47715889
74RPS6KB20.47604759
75FGFR20.47421025
76AURKA0.46635095
77KSR20.45124725
78FES0.44507037
79ZAP700.44047583
80PRKAA10.42718117
81RPS6KA20.42325072
82PKN10.42218432
83PIM10.42045923
84TNK20.42015083
85PTK60.41819834
86MAPK70.41512186
87HIPK20.41011560
88ITK0.40600223
89PDGFRA0.38225933
90MAP3K70.36067348
91SGK2230.35546514
92SGK4940.35546514
93MAPKAPK20.33108692
94HCK0.33097518
95AKT20.31389854
96MAPK30.30576084
97MAPK80.29694055
98MAP3K10.27645213
99CAMKK10.27224742
100CSNK1D0.26527566

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.58597136
2Primary immunodeficiency_Homo sapiens_hsa053404.01189975
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.82513385
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30372388
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.08299976
6Allograft rejection_Homo sapiens_hsa053302.84505283
7Alcoholism_Homo sapiens_hsa050342.73061552
8Autoimmune thyroid disease_Homo sapiens_hsa053202.66941575
9Graft-versus-host disease_Homo sapiens_hsa053322.33739450
10Sulfur relay system_Homo sapiens_hsa041222.32269800
11Asthma_Homo sapiens_hsa053102.19478370
12Other glycan degradation_Homo sapiens_hsa005112.09665367
13B cell receptor signaling pathway_Homo sapiens_hsa046621.99707765
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.95741594
15Type I diabetes mellitus_Homo sapiens_hsa049401.90482270
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.89422675
17Fructose and mannose metabolism_Homo sapiens_hsa000511.86365078
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.72634696
19Viral carcinogenesis_Homo sapiens_hsa052031.54730782
20Viral myocarditis_Homo sapiens_hsa054161.46487002
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.41319669
22Herpes simplex infection_Homo sapiens_hsa051681.35152183
23T cell receptor signaling pathway_Homo sapiens_hsa046601.30372246
24Leishmaniasis_Homo sapiens_hsa051401.26398910
25Phenylalanine metabolism_Homo sapiens_hsa003601.23061628
26Staphylococcus aureus infection_Homo sapiens_hsa051501.20114622
27Vitamin digestion and absorption_Homo sapiens_hsa049771.16946036
28Influenza A_Homo sapiens_hsa051641.12250973
29Antigen processing and presentation_Homo sapiens_hsa046121.04704214
30Measles_Homo sapiens_hsa051621.02677169
31Apoptosis_Homo sapiens_hsa042101.01455310
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00191540
33RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99380796
34Non-small cell lung cancer_Homo sapiens_hsa052230.94070074
35Toxoplasmosis_Homo sapiens_hsa051450.93050072
36Epstein-Barr virus infection_Homo sapiens_hsa051690.90725927
37Hepatitis B_Homo sapiens_hsa051610.90474892
38Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89147049
39ABC transporters_Homo sapiens_hsa020100.88358525
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83605039
41Hematopoietic cell lineage_Homo sapiens_hsa046400.82850754
42Sphingolipid metabolism_Homo sapiens_hsa006000.82497644
43Lysine degradation_Homo sapiens_hsa003100.79500950
44Hepatitis C_Homo sapiens_hsa051600.77680640
45Arginine biosynthesis_Homo sapiens_hsa002200.77024254
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.76835808
47Acute myeloid leukemia_Homo sapiens_hsa052210.75398041
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74419974
49Complement and coagulation cascades_Homo sapiens_hsa046100.72437146
50Insulin resistance_Homo sapiens_hsa049310.70514052
51HTLV-I infection_Homo sapiens_hsa051660.70403979
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.69964353
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68321151
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67306653
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67064235
56VEGF signaling pathway_Homo sapiens_hsa043700.65768754
57TNF signaling pathway_Homo sapiens_hsa046680.65054758
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.64077295
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59797910
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.59571793
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59158069
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54632509
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53943748
64N-Glycan biosynthesis_Homo sapiens_hsa005100.53204814
65Fat digestion and absorption_Homo sapiens_hsa049750.52541357
66Circadian rhythm_Homo sapiens_hsa047100.51986042
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51563195
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49420217
69One carbon pool by folate_Homo sapiens_hsa006700.49395768
70Tuberculosis_Homo sapiens_hsa051520.49052210
71mTOR signaling pathway_Homo sapiens_hsa041500.48886608
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48686467
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48444088
74Biosynthesis of amino acids_Homo sapiens_hsa012300.48229442
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44951257
76Osteoclast differentiation_Homo sapiens_hsa043800.44532883
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43890424
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40379719
79Small cell lung cancer_Homo sapiens_hsa052220.40107582
80MAPK signaling pathway_Homo sapiens_hsa040100.39295124
81Prostate cancer_Homo sapiens_hsa052150.38204911
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.37707260
83Endometrial cancer_Homo sapiens_hsa052130.36057193
84Chronic myeloid leukemia_Homo sapiens_hsa052200.35922808
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.34572280
86Inositol phosphate metabolism_Homo sapiens_hsa005620.31838907
87Bladder cancer_Homo sapiens_hsa052190.31492212
88PPAR signaling pathway_Homo sapiens_hsa033200.31310975
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.29630320
90Base excision repair_Homo sapiens_hsa034100.27040044
91Prolactin signaling pathway_Homo sapiens_hsa049170.27028958
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22432082
93p53 signaling pathway_Homo sapiens_hsa041150.21172252
94Fatty acid metabolism_Homo sapiens_hsa012120.21043647
95Glycerolipid metabolism_Homo sapiens_hsa005610.20762814
96Arginine and proline metabolism_Homo sapiens_hsa003300.20389042
97Insulin signaling pathway_Homo sapiens_hsa049100.19829597
98Chemokine signaling pathway_Homo sapiens_hsa040620.19233843
99FoxO signaling pathway_Homo sapiens_hsa040680.18793715
100HIF-1 signaling pathway_Homo sapiens_hsa040660.18063433

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