LIN52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.88782848
2water-soluble vitamin biosynthetic process (GO:0042364)5.19587568
3NADH metabolic process (GO:0006734)4.79327305
4synaptic vesicle exocytosis (GO:0016079)4.44219147
5transferrin transport (GO:0033572)4.29186871
6nonmotile primary cilium assembly (GO:0035058)4.27652624
7monoubiquitinated protein deubiquitination (GO:0035520)4.24511426
8protein deneddylation (GO:0000338)4.18768673
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.14636685
10chaperone-mediated protein transport (GO:0072321)4.12419086
11succinate metabolic process (GO:0006105)4.10530930
12cullin deneddylation (GO:0010388)4.06970024
13negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.04804252
14ferric iron transport (GO:0015682)3.97071680
15trivalent inorganic cation transport (GO:0072512)3.97071680
16DNA deamination (GO:0045006)3.93927925
17regulation of synaptic vesicle exocytosis (GO:2000300)3.81521533
18somite development (GO:0061053)3.77517951
19GMP metabolic process (GO:0046037)3.75323795
20neurotransmitter-gated ion channel clustering (GO:0072578)3.74451332
21energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.74199323
22ATP hydrolysis coupled proton transport (GO:0015991)3.74199323
23tricarboxylic acid cycle (GO:0006099)3.73131097
24purine nucleobase biosynthetic process (GO:0009113)3.71566229
25tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70215664
26RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70215664
27indolalkylamine metabolic process (GO:0006586)3.70169352
28positive regulation of mitochondrial fission (GO:0090141)3.66899021
29oxaloacetate metabolic process (GO:0006107)3.65848031
30regulation of synaptic vesicle transport (GO:1902803)3.51753373
31negative regulation of membrane potential (GO:0045837)3.48212069
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.47783699
33gamma-aminobutyric acid transport (GO:0015812)3.47518737
34retinal rod cell development (GO:0046548)3.46281457
35protein-cofactor linkage (GO:0018065)3.45200063
36response to misfolded protein (GO:0051788)3.42388862
37nucleobase biosynthetic process (GO:0046112)3.41171032
38striatum development (GO:0021756)3.39712035
39magnesium ion transport (GO:0015693)3.39317600
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.35526906
41negative regulation of transcription regulatory region DNA binding (GO:2000678)3.35294944
42protein polyglutamylation (GO:0018095)3.33659555
43sulfation (GO:0051923)3.30284919
44histone H2A acetylation (GO:0043968)3.30179934
45maturation of 5.8S rRNA (GO:0000460)3.29435597
46intraciliary transport (GO:0042073)3.28575327
47protein complex biogenesis (GO:0070271)3.27702805
48glutamate secretion (GO:0014047)3.27183343
49neuron cell-cell adhesion (GO:0007158)3.18445605
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16717634
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.16717634
52NADH dehydrogenase complex assembly (GO:0010257)3.16717634
53kidney morphogenesis (GO:0060993)3.15266660
54positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.13068729
55mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.13068729
56replication fork processing (GO:0031297)3.08666098
57serotonin metabolic process (GO:0042428)3.08515712
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07637055
59neurotransmitter secretion (GO:0007269)3.07237696
60regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.04980916
61regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.04980916
62regulation of mesoderm development (GO:2000380)3.02484618
63positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.01565430
64primary amino compound metabolic process (GO:1901160)3.01238962
65cell proliferation in forebrain (GO:0021846)3.01090264
66DNA double-strand break processing (GO:0000729)3.00612375
67base-excision repair, AP site formation (GO:0006285)3.00564128
68vocalization behavior (GO:0071625)2.99359076
69protein localization to synapse (GO:0035418)2.97602123
70adaptation of signaling pathway (GO:0023058)2.96867964
71mitochondrial respiratory chain complex assembly (GO:0033108)2.96629744
72negative regulation of DNA-templated transcription, elongation (GO:0032785)2.95874409
73fucose catabolic process (GO:0019317)2.94923093
74L-fucose metabolic process (GO:0042354)2.94923093
75L-fucose catabolic process (GO:0042355)2.94923093
76protein neddylation (GO:0045116)2.94282031
77platelet dense granule organization (GO:0060155)2.93937127
78protein K6-linked ubiquitination (GO:0085020)2.90556694
79negative regulation of systemic arterial blood pressure (GO:0003085)2.90265278
80positive regulation of synapse maturation (GO:0090129)2.88503368
817-methylguanosine RNA capping (GO:0009452)2.88086504
82RNA capping (GO:0036260)2.88086504
83indole-containing compound metabolic process (GO:0042430)2.87030827
84amino acid salvage (GO:0043102)2.87012589
85L-methionine salvage (GO:0071267)2.87012589
86L-methionine biosynthetic process (GO:0071265)2.87012589
87establishment of protein localization to mitochondrial membrane (GO:0090151)2.86610775
88regulation of neurotransmitter uptake (GO:0051580)2.86433972
89lactate metabolic process (GO:0006089)2.85686664
90indole-containing compound catabolic process (GO:0042436)2.84827521
91indolalkylamine catabolic process (GO:0046218)2.84827521
92tryptophan catabolic process (GO:0006569)2.84827521
93pseudouridine synthesis (GO:0001522)2.84342477
94kynurenine metabolic process (GO:0070189)2.84215779
95purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.84151759
963-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.84151759
97regulation of cilium movement (GO:0003352)2.82535107
987-methylguanosine mRNA capping (GO:0006370)2.82439186
99mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.82104648
100regulation of mitochondrial fission (GO:0090140)2.81270111
101long-term synaptic potentiation (GO:0060291)2.78874263
102gamma-aminobutyric acid signaling pathway (GO:0007214)2.78842890
103neuron-neuron synaptic transmission (GO:0007270)2.78841473
104nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78283961
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75954133
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75331571
107protein prenylation (GO:0018342)2.74976271
108prenylation (GO:0097354)2.74976271
109neurotransmitter uptake (GO:0001504)2.74755980
110epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74055269
111regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73833255
112detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.73336822
113membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.73267427
114startle response (GO:0001964)2.73053731
115ATP synthesis coupled proton transport (GO:0015986)2.72264298
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.72264298
117response to histamine (GO:0034776)2.72157693
118preassembly of GPI anchor in ER membrane (GO:0016254)2.70439453
119membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69552014
120epithelial cilium movement (GO:0003351)2.69394934
121regulation of acyl-CoA biosynthetic process (GO:0050812)2.69334274
122regulation of neurotransmitter transport (GO:0051588)2.67947486
123transmission of nerve impulse (GO:0019226)2.67909627
124negative regulation of telomere maintenance (GO:0032205)2.67666786
125detection of light stimulus involved in sensory perception (GO:0050962)2.67412468
126detection of light stimulus involved in visual perception (GO:0050908)2.67412468
127termination of RNA polymerase III transcription (GO:0006386)2.67335700
128transcription elongation from RNA polymerase III promoter (GO:0006385)2.67335700
129cytochrome complex assembly (GO:0017004)2.67243891
130mitochondrial fission (GO:0000266)2.67151687
131synaptic transmission, glutamatergic (GO:0035249)2.66716893
132phagosome maturation (GO:0090382)2.66515515
133respiratory chain complex IV assembly (GO:0008535)2.65796586
134spinal cord motor neuron differentiation (GO:0021522)2.65569198
135mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.65258026
136retinal ganglion cell axon guidance (GO:0031290)2.64715092
137protein import into peroxisome matrix (GO:0016558)2.64397723
138regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.63979372
139guanosine-containing compound biosynthetic process (GO:1901070)2.63419878
140regulation of cofactor metabolic process (GO:0051193)2.62211228
141regulation of coenzyme metabolic process (GO:0051196)2.62211228
142synaptic vesicle transport (GO:0048489)2.61796963
143establishment of synaptic vesicle localization (GO:0097480)2.61796963
144regulation of neurotransmitter secretion (GO:0046928)2.61666059
145positive regulation of fatty acid transport (GO:2000193)2.61560836
146presynaptic membrane assembly (GO:0097105)2.61179850
147protein K48-linked deubiquitination (GO:0071108)2.61074165
148regulation of synapse structural plasticity (GO:0051823)2.60399123
149positive regulation of oligodendrocyte differentiation (GO:0048714)2.60200380
150melanosome transport (GO:0032402)2.59097234
151inositol phosphate catabolic process (GO:0071545)2.58992873
152intracellular protein transmembrane import (GO:0044743)2.58732618
153positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.57868174
154proteasome assembly (GO:0043248)2.57839190
155establishment of melanosome localization (GO:0032401)2.57790469
156postsynaptic membrane organization (GO:0001941)2.57193907
157piRNA metabolic process (GO:0034587)2.56036127
158negative regulation of dendrite morphogenesis (GO:0050774)2.55767150
159misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.55688747
160regulation of meiosis I (GO:0060631)2.55428732
161mannosylation (GO:0097502)2.55407609
162retinal cone cell development (GO:0046549)2.53762028
163negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.53403552
164dentate gyrus development (GO:0021542)2.53266188
165prostate gland growth (GO:0060736)2.53029917
166regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.52884097
167regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52832523
168negative regulation of mast cell activation (GO:0033004)2.52808297
169rRNA catabolic process (GO:0016075)2.52397953
170membrane repolarization during action potential (GO:0086011)2.52122803
171pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.50962959
172viral protein processing (GO:0019082)2.50938231
173negative regulation of appetite (GO:0032099)2.50646073
174negative regulation of response to food (GO:0032096)2.50646073
175synaptic transmission, cholinergic (GO:0007271)2.50384170
176neurotransmitter transport (GO:0006836)2.50166990
177RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.48694127
178limb development (GO:0060173)2.46607845
179appendage development (GO:0048736)2.46607845
180tryptophan metabolic process (GO:0006568)2.45202523
181positive regulation of meiosis (GO:0045836)2.44772904
182regulation of DNA endoreduplication (GO:0032875)2.44579999
183embryonic epithelial tube formation (GO:0001838)2.43386198
184photoreceptor cell development (GO:0042461)2.43180246
185positive regulation of potassium ion transmembrane transport (GO:1901381)2.43104001
186presynaptic membrane organization (GO:0097090)2.42693386
187response to pheromone (GO:0019236)2.41615768

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.76646725
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70803610
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.31600997
4ZNF274_21170338_ChIP-Seq_K562_Hela3.31218007
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95090373
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87819270
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.86346697
8PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.85088264
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.79666030
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74107669
11GBX2_23144817_ChIP-Seq_PC3_Human2.69387032
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.65923626
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61174316
14TAF15_26573619_Chip-Seq_HEK293_Human2.56618118
15EZH2_22144423_ChIP-Seq_EOC_Human2.52262934
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45095521
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43201021
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.34843196
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28880702
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.26140168
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.24120797
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21329209
23SRF_21415370_ChIP-Seq_HL-1_Mouse2.20416683
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.13909614
25YY1_21170310_ChIP-Seq_MESCs_Mouse2.07642267
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06366489
27VDR_23849224_ChIP-Seq_CD4+_Human1.89846258
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.87878378
29IGF1R_20145208_ChIP-Seq_DFB_Human1.82710804
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82080365
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77858256
32* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74806689
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72605143
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71005775
35REST_21632747_ChIP-Seq_MESCs_Mouse1.69755750
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69601647
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69321256
38FUS_26573619_Chip-Seq_HEK293_Human1.67780281
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.67351497
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65883510
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65776080
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64704732
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.64089523
44FOXP3_21729870_ChIP-Seq_TREG_Human1.63209894
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.61696086
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59612094
47FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.58295537
48* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57879917
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55856586
50E2F7_22180533_ChIP-Seq_HELA_Human1.55170233
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54712286
52VDR_22108803_ChIP-Seq_LS180_Human1.54280592
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53378886
54CBP_20019798_ChIP-Seq_JUKART_Human1.51508190
55IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51508190
56GABP_19822575_ChIP-Seq_HepG2_Human1.49600090
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48924836
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.48762020
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44334442
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44213161
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43196892
62FLI1_27457419_Chip-Seq_LIVER_Mouse1.41941706
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.40015483
64BCAT_22108803_ChIP-Seq_LS180_Human1.39887782
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39835538
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.38423295
67TP53_22573176_ChIP-Seq_HFKS_Human1.37083871
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36661839
69EWS_26573619_Chip-Seq_HEK293_Human1.36390709
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.35587955
71CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.34782599
72RNF2_27304074_Chip-Seq_NSC_Mouse1.33955813
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33375994
74E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31188030
75EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28807031
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26146362
77JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25027618
78STAT3_23295773_ChIP-Seq_U87_Human1.24918893
79DCP1A_22483619_ChIP-Seq_HELA_Human1.24414754
80SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24301468
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23882112
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22621187
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22487243
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22044796
85GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21975016
86* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.21260557
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18873302
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.18873302
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17852446
90NCOR_22424771_ChIP-Seq_293T_Human1.17683559
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17483758
92ER_23166858_ChIP-Seq_MCF-7_Human1.17012806
93GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16586605
94TCF4_23295773_ChIP-Seq_U87_Human1.15473921
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15195322
96REST_19997604_ChIP-ChIP_NEURONS_Mouse1.13641097
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.12864082
98ELK1_19687146_ChIP-ChIP_HELA_Human1.12862278
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12808396
100AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12724709
101P300_19829295_ChIP-Seq_ESCs_Human1.12576615
102SMAD4_21799915_ChIP-Seq_A2780_Human1.11973590
103HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11705274
104SOX2_19829295_ChIP-Seq_ESCs_Human1.09902705
105NANOG_19829295_ChIP-Seq_ESCs_Human1.09902705
106KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08589681
107HTT_18923047_ChIP-ChIP_STHdh_Human1.08554979
108* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08030775
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.07786503
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05912306
111CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05637549
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05584124
113MYC_18555785_ChIP-Seq_MESCs_Mouse1.05454618
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04545097
115CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04179898
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.03658200
117JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02510558
118MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01489752
119POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01449497
120TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01449497
121SOX9_26525672_Chip-Seq_HEART_Mouse1.01072033
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.01030931
123NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99479183
124GATA3_21878914_ChIP-Seq_MCF-7_Human0.96762381
125* FLI1_21867929_ChIP-Seq_TH2_Mouse0.96683972
126KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96634542
127FOXA1_21572438_ChIP-Seq_LNCaP_Human0.96437442
128TCF4_22108803_ChIP-Seq_LS180_Human0.96067303
129XRN2_22483619_ChIP-Seq_HELA_Human0.95470223
130CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93697864
131STAT3_18555785_Chip-Seq_ESCs_Mouse0.92452047
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92048457
133JUN_21703547_ChIP-Seq_K562_Human0.91138700
134BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89482971
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87903271
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87701657
137NOTCH1_21737748_ChIP-Seq_TLL_Human0.87643520
138IRF1_19129219_ChIP-ChIP_H3396_Human0.87526337
139RARB_27405468_Chip-Seq_BRAIN_Mouse0.87218506
140AR_25329375_ChIP-Seq_VCAP_Human0.86026990
141TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85437774
142* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84845628
143SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84204085
144SALL4_22934838_ChIP-ChIP_CD34+_Human0.83827159
145RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83729931
146SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82460160
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80519640
148MYC_18940864_ChIP-ChIP_HL60_Human0.80456934
149FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.80210201
150CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80183505
151PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79579110
152* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78754838
153NFE2_27457419_Chip-Seq_LIVER_Mouse0.78399987
154SOX2_18555785_Chip-Seq_ESCs_Mouse0.78032880
155NANOG_18555785_Chip-Seq_ESCs_Mouse0.77619341

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.51327873
2MP0005646_abnormal_pituitary_gland3.18825750
3MP0008877_abnormal_DNA_methylation2.99599434
4MP0009046_muscle_twitch2.98979770
5MP0004859_abnormal_synaptic_plasticity2.90445990
6MP0001984_abnormal_olfaction2.84314352
7MP0003635_abnormal_synaptic_transmissio2.54698093
8MP0002102_abnormal_ear_morphology2.52631687
9MP0009745_abnormal_behavioral_response2.46713535
10MP0001529_abnormal_vocalization2.45891697
11MP0003787_abnormal_imprinting2.32159019
12MP0002064_seizures2.28386183
13MP0001986_abnormal_taste_sensitivity2.23903558
14MP0002063_abnormal_learning/memory/cond2.15684040
15MP0002736_abnormal_nociception_after2.12079703
16MP0001188_hyperpigmentation2.11319152
17MP0002572_abnormal_emotion/affect_behav2.07895463
18MP0003011_delayed_dark_adaptation2.06433716
19MP0001968_abnormal_touch/_nociception2.06360816
20MP0002272_abnormal_nervous_system2.04110769
21MP0002734_abnormal_mechanical_nocicepti2.03952642
22MP0003122_maternal_imprinting1.99562051
23MP0004133_heterotaxia1.99497775
24MP0003879_abnormal_hair_cell1.96571056
25MP0006292_abnormal_olfactory_placode1.95343029
26MP0005645_abnormal_hypothalamus_physiol1.91103694
27MP0001501_abnormal_sleep_pattern1.89804848
28MP0002638_abnormal_pupillary_reflex1.86682989
29MP0005551_abnormal_eye_electrophysiolog1.82287224
30MP0004885_abnormal_endolymph1.80057861
31MP0002938_white_spotting1.77904781
32MP0000049_abnormal_middle_ear1.75169320
33MP0003121_genomic_imprinting1.74750953
34MP0001502_abnormal_circadian_rhythm1.73299915
35MP0002822_catalepsy1.72405515
36MP0004147_increased_porphyrin_level1.71685288
37MP0003646_muscle_fatigue1.69582559
38MP0005499_abnormal_olfactory_system1.68264588
39MP0005394_taste/olfaction_phenotype1.68264588
40MP0008260_abnormal_autophagy1.67053476
41MP0001485_abnormal_pinna_reflex1.66421088
42MP0004270_analgesia1.65242537
43MP0008789_abnormal_olfactory_epithelium1.63106877
44MP0002160_abnormal_reproductive_system1.60136877
45MP0001486_abnormal_startle_reflex1.59918625
46MP0003283_abnormal_digestive_organ1.58283051
47MP0002653_abnormal_ependyma_morphology1.57515861
48MP0003890_abnormal_embryonic-extraembry1.53338637
49MP0002735_abnormal_chemical_nociception1.53229776
50MP0002067_abnormal_sensory_capabilities1.50728477
51MP0003195_calcinosis1.49715035
52MP0002876_abnormal_thyroid_physiology1.46162172
53MP0004145_abnormal_muscle_electrophysio1.44295661
54MP0001905_abnormal_dopamine_level1.44118614
55MP0005389_reproductive_system_phenotype1.43836631
56MP0010094_abnormal_chromosome_stability1.40278091
57MP0002557_abnormal_social/conspecific_i1.39218291
58MP0002132_abnormal_respiratory_system1.36478708
59MP0006072_abnormal_retinal_apoptosis1.34838392
60MP0008872_abnormal_physiological_respon1.34675802
61MP0004043_abnormal_pH_regulation1.32203470
62MP0003123_paternal_imprinting1.31790264
63MP0003718_maternal_effect1.31013630
64MP0000537_abnormal_urethra_morphology1.30802554
65MP0002234_abnormal_pharynx_morphology1.30044941
66MP0004742_abnormal_vestibular_system1.28702504
67MP0008775_abnormal_heart_ventricle1.28698372
68MP0008875_abnormal_xenobiotic_pharmacok1.28545836
69MP0008058_abnormal_DNA_repair1.26709255
70MP0003938_abnormal_ear_development1.26589510
71MP0001970_abnormal_pain_threshold1.25942079
72MP0000569_abnormal_digit_pigmentation1.25526798
73MP0003136_yellow_coat_color1.22202142
74MP0003937_abnormal_limbs/digits/tail_de1.22064875
75MP0006276_abnormal_autonomic_nervous1.21900692
76MP0006036_abnormal_mitochondrial_physio1.21235468
77MP0005171_absent_coat_pigmentation1.20401046
78MP0005253_abnormal_eye_physiology1.19931422
79MP0006035_abnormal_mitochondrial_morpho1.18763067
80MP0004142_abnormal_muscle_tone1.18727327
81MP0008569_lethality_at_weaning1.18101100
82MP0002733_abnormal_thermal_nociception1.16975361
83MP0004130_abnormal_muscle_cell1.15541170
84MP0001440_abnormal_grooming_behavior1.14471645
85MP0005670_abnormal_white_adipose1.10332332
86MP0002184_abnormal_innervation1.10316978
87MP0005423_abnormal_somatic_nervous1.07997995
88MP0003119_abnormal_digestive_system1.07431929
89MP0002928_abnormal_bile_duct1.05500420
90MP0002751_abnormal_autonomic_nervous1.05432936
91MP0003567_abnormal_fetal_cardiomyocyte1.04302128
92MP0005084_abnormal_gallbladder_morpholo1.03567679
93MP0003693_abnormal_embryo_hatching1.03550179
94MP0000631_abnormal_neuroendocrine_gland1.02805783
95MP0003698_abnormal_male_reproductive1.02150471
96MP0009697_abnormal_copulation0.99992762
97MP0002090_abnormal_vision0.99803082
98MP0001293_anophthalmia0.99560387
99MP0001764_abnormal_homeostasis0.98952096
100MP0005386_behavior/neurological_phenoty0.98284442
101MP0004924_abnormal_behavior0.98284442
102MP0001963_abnormal_hearing_physiology0.97403309
103MP0005379_endocrine/exocrine_gland_phen0.96994638
104MP0001929_abnormal_gametogenesis0.96474311
105MP0002882_abnormal_neuron_morphology0.95068139
106MP0000955_abnormal_spinal_cord0.94497994
107MP0001919_abnormal_reproductive_system0.93869115
108MP0002066_abnormal_motor_capabilities/c0.93780989
109MP0005367_renal/urinary_system_phenotyp0.93613221
110MP0000516_abnormal_urinary_system0.93613221
111MP0005195_abnormal_posterior_eye0.92890536
112MP0008057_abnormal_DNA_replication0.92667398
113MP0004215_abnormal_myocardial_fiber0.91681902
114MP0004811_abnormal_neuron_physiology0.90380449
115MP0000013_abnormal_adipose_tissue0.87041318
116MP0008995_early_reproductive_senescence0.84961652
117MP0002277_abnormal_respiratory_mucosa0.82733851
118MP0002069_abnormal_eating/drinking_beha0.82113876
119MP0003111_abnormal_nucleus_morphology0.81593193
120MP0002210_abnormal_sex_determination0.81580138
121MP0003077_abnormal_cell_cycle0.81524063
122MP0002163_abnormal_gland_morphology0.81095214
123MP0002138_abnormal_hepatobiliary_system0.80992181
124MP0005174_abnormal_tail_pigmentation0.79967406
125MP0000778_abnormal_nervous_system0.79018318
126MP0002229_neurodegeneration0.78327354
127MP0003786_premature_aging0.77372361
128MP0000427_abnormal_hair_cycle0.76786889
129MP0002282_abnormal_trachea_morphology0.76451990
130MP0002837_dystrophic_cardiac_calcinosis0.76339409
131MP0010386_abnormal_urinary_bladder0.76009631
132MP0000653_abnormal_sex_gland0.75727400
133MP0003656_abnormal_erythrocyte_physiolo0.75089037
134MP0000026_abnormal_inner_ear0.74880043
135MP0008007_abnormal_cellular_replicative0.74663774
136MP0003329_amyloid_beta_deposits0.74279468
137MP0002752_abnormal_somatic_nervous0.73841724
138MP0004085_abnormal_heartbeat0.71904429
139MP0000372_irregular_coat_pigmentation0.70866790
140MP0003183_abnormal_peptide_metabolism0.70257909
141MP0001270_distended_abdomen0.69883338
142MP0002152_abnormal_brain_morphology0.69844428

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.74396677
2Gait imbalance (HP:0002141)4.57270197
3Congenital primary aphakia (HP:0007707)4.54200222
4Cutaneous melanoma (HP:0012056)4.51269535
5Medial flaring of the eyebrow (HP:0010747)4.42239471
6Nephrogenic diabetes insipidus (HP:0009806)4.40794854
7Epileptic encephalopathy (HP:0200134)4.07242790
8Hyperventilation (HP:0002883)3.84436569
9Abnormal hair whorl (HP:0010721)3.84347412
10Atonic seizures (HP:0010819)3.71458293
11Febrile seizures (HP:0002373)3.65544802
12Poor coordination (HP:0002370)3.54877740
13Abnormal mitochondria in muscle tissue (HP:0008316)3.54749208
14Acute necrotizing encephalopathy (HP:0006965)3.35555702
15Pancreatic fibrosis (HP:0100732)3.35501785
16Nephronophthisis (HP:0000090)3.26239803
17Abnormality of the labia minora (HP:0012880)3.24959926
18Hepatocellular necrosis (HP:0001404)3.11772551
19Genital tract atresia (HP:0001827)3.11557331
20Vaginal atresia (HP:0000148)3.10491108
21Poor suck (HP:0002033)3.08302650
22Hyperglycinemia (HP:0002154)3.00394740
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.99508563
24Abnormality of alanine metabolism (HP:0010916)2.99508563
25Hyperalaninemia (HP:0003348)2.99508563
26Congenital, generalized hypertrichosis (HP:0004540)2.96819962
27Abnormality of glycolysis (HP:0004366)2.92545001
28Increased serum pyruvate (HP:0003542)2.92545001
29Increased CSF lactate (HP:0002490)2.91334667
30Acute encephalopathy (HP:0006846)2.88515440
31Oligomenorrhea (HP:0000876)2.88207580
32Mitochondrial inheritance (HP:0001427)2.83245977
33True hermaphroditism (HP:0010459)2.82667245
34Absence seizures (HP:0002121)2.80917779
35Pendular nystagmus (HP:0012043)2.72626099
36Broad foot (HP:0001769)2.71138707
37Progressive macrocephaly (HP:0004481)2.70520272
38Failure to thrive in infancy (HP:0001531)2.68455249
39Meningioma (HP:0002858)2.67572557
40Abnormality of the renal medulla (HP:0100957)2.64560449
41Polyphagia (HP:0002591)2.63082223
42Stenosis of the external auditory canal (HP:0000402)2.62352047
43Abnormality of the renal collecting system (HP:0004742)2.61939138
44Neuroendocrine neoplasm (HP:0100634)2.61671475
45Protruding tongue (HP:0010808)2.55947023
46Visual hallucinations (HP:0002367)2.55469930
47Pheochromocytoma (HP:0002666)2.55154198
48Aplasia/Hypoplasia of the tibia (HP:0005772)2.51787921
49Specific learning disability (HP:0001328)2.48255590
50Pancreatic cysts (HP:0001737)2.48179888
51Progressive cerebellar ataxia (HP:0002073)2.48155016
52Aplasia/Hypoplasia of the lens (HP:0008063)2.47547482
53Abnormality of the proximal phalanges of the hand (HP:0009834)2.47123044
54Hepatic necrosis (HP:0002605)2.45270473
55Abnormality of midbrain morphology (HP:0002418)2.44470084
56Molar tooth sign on MRI (HP:0002419)2.44470084
57Short tibia (HP:0005736)2.40901823
58Abolished electroretinogram (ERG) (HP:0000550)2.40862696
59Type II lissencephaly (HP:0007260)2.39888717
60Dialeptic seizures (HP:0011146)2.39839318
61Birth length less than 3rd percentile (HP:0003561)2.37488866
62Sclerocornea (HP:0000647)2.31332780
63Myokymia (HP:0002411)2.29836737
643-Methylglutaconic aciduria (HP:0003535)2.29748289
65Lactic acidosis (HP:0003128)2.27495436
66Small hand (HP:0200055)2.25361680
67Unsteady gait (HP:0002317)2.24401072
68Decreased testicular size (HP:0008734)2.23793722
69Abnormality of the renal cortex (HP:0011035)2.23321109
70Aplasia/hypoplasia of the uterus (HP:0008684)2.23274863
71Type 2 muscle fiber atrophy (HP:0003554)2.23089571
72Absent thumb (HP:0009777)2.19414837
73Generalized tonic-clonic seizures (HP:0002069)2.19243120
74Ectopic kidney (HP:0000086)2.17164329
75Microvesicular hepatic steatosis (HP:0001414)2.16180645
76Methylmalonic aciduria (HP:0012120)2.16106235
77Short 1st metacarpal (HP:0010034)2.15858142
78Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.15858142
79Abnormality of the middle phalanges of the toes (HP:0010183)2.15776640
80Abnormal eating behavior (HP:0100738)2.15135841
81Carpal bone hypoplasia (HP:0001498)2.14907225
82Hypoplasia of the uterus (HP:0000013)2.14375336
83Increased serum lactate (HP:0002151)2.12879880
84Congenital sensorineural hearing impairment (HP:0008527)2.12742261
85Cystic liver disease (HP:0006706)2.10713508
86Morphological abnormality of the middle ear (HP:0008609)2.10634348
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.10587193
88Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.08653741
89Congenital stationary night blindness (HP:0007642)2.08239558
90Cerebral hypomyelination (HP:0006808)2.07858453
91Hypothermia (HP:0002045)2.06250076
92Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05632115
93Truncal ataxia (HP:0002078)2.04708636
94Rhinitis (HP:0012384)2.03630063
95Postaxial hand polydactyly (HP:0001162)2.03597098
96Abnormality of the anterior horn cell (HP:0006802)2.01544450
97Degeneration of anterior horn cells (HP:0002398)2.01544450
98Chronic hepatic failure (HP:0100626)2.01520143
99Attenuation of retinal blood vessels (HP:0007843)2.01295126
100Chorioretinal atrophy (HP:0000533)2.01156883
101Genetic anticipation (HP:0003743)2.00889392
102CNS demyelination (HP:0007305)2.00447907
103Focal seizures (HP:0007359)1.99551655
104Aplasia/Hypoplasia of the hallux (HP:0008362)1.98434063
105Abnormality of the phalanges of the 5th finger (HP:0004213)1.97086457
106Abnormality of glycine metabolism (HP:0010895)1.96257763
107Abnormality of serine family amino acid metabolism (HP:0010894)1.96257763
108Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96196550
109Short hallux (HP:0010109)1.96156659
110Leukodystrophy (HP:0002415)1.95579199
111Male pseudohermaphroditism (HP:0000037)1.94963566
112Symphalangism affecting the phalanges of the hand (HP:0009773)1.93896954
113Aplasia/Hypoplasia of the patella (HP:0006498)1.93744862
114Abnormality of the heme biosynthetic pathway (HP:0010472)1.93520331
115Left ventricular hypertrophy (HP:0001712)1.93241068
116Anencephaly (HP:0002323)1.92116805
117Gaze-evoked nystagmus (HP:0000640)1.91644500
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.91344423
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.91297476
120Increased corneal curvature (HP:0100692)1.90926304
121Keratoconus (HP:0000563)1.90926304
122Emotional lability (HP:0000712)1.90834588
123Aplasia/Hypoplasia of the spleen (HP:0010451)1.90405292
124Abnormality of vitamin B metabolism (HP:0004340)1.90297798
125Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89997463
126Respiratory failure (HP:0002878)1.89982038
127Facial cleft (HP:0002006)1.89160714
128Median cleft lip (HP:0000161)1.87649778
129Abnormality of the vitamin B12 metabolism (HP:0004341)1.87355195
130Furrowed tongue (HP:0000221)1.87234193
131Abnormality of the 1st metacarpal (HP:0010009)1.85344710
132Broad-based gait (HP:0002136)1.85211909
133Postaxial foot polydactyly (HP:0001830)1.84966193
134Abnormal rod and cone electroretinograms (HP:0008323)1.84411767
135Muscle fiber atrophy (HP:0100295)1.83598138
136Patellar aplasia (HP:0006443)1.83319703
137CNS hypomyelination (HP:0003429)1.83053991
138IgG deficiency (HP:0004315)1.82594390
139Impaired smooth pursuit (HP:0007772)1.81868341
140Renal cortical cysts (HP:0000803)1.81617217
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81445591
142Optic disc pallor (HP:0000543)1.80412196
143Papillary thyroid carcinoma (HP:0002895)1.78464894
144Concave nail (HP:0001598)1.77413800
145Methylmalonic acidemia (HP:0002912)1.77075849
146Limb dystonia (HP:0002451)1.76486842
147Exercise intolerance (HP:0003546)1.75615385
148Humeroradial synostosis (HP:0003041)1.75595676
149Synostosis involving the elbow (HP:0003938)1.75595676
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.75509493
151Absent/shortened dynein arms (HP:0200106)1.75509493
152Delusions (HP:0000746)1.74774557
153Abnormality of the fovea (HP:0000493)1.74604441
154Thyroiditis (HP:0100646)1.74455024
155Asplenia (HP:0001746)1.74099765
156Septo-optic dysplasia (HP:0100842)1.73908528
157Abnormality of ocular smooth pursuit (HP:0000617)1.73180880
158Epileptiform EEG discharges (HP:0011182)1.72688792
159Central scotoma (HP:0000603)1.71652586
160Asthma (HP:0002099)1.71236074
161Split foot (HP:0001839)1.70423865
162Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70271307
163Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70271307
164Hypoplasia of the fovea (HP:0007750)1.70089929
165Aplasia/Hypoplasia of the fovea (HP:0008060)1.70089929
166Polydipsia (HP:0001959)1.69111275
167Abnormal drinking behavior (HP:0030082)1.69111275
168Type I transferrin isoform profile (HP:0003642)1.68939641
169Hemiparesis (HP:0001269)1.68846246
170Duplicated collecting system (HP:0000081)1.68833901
171Infertility (HP:0000789)1.66949557
172Retinitis pigmentosa (HP:0000510)1.65165697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.75680099
2CASK4.19697384
3TSSK63.12171600
4PDK42.92680190
5PDK32.92680190
6TLK12.84135138
7CCNB12.77125626
8BUB12.57424719
9STK162.51469054
10AKT32.51142181
11MAP2K72.45460039
12MAP3K122.43922314
13NUAK12.39235241
14MAP4K22.28735907
15CDK82.25567660
16PLK22.09349558
17TAOK32.02668493
18PDK21.93535010
19ACVR1B1.84623460
20CDK191.84288091
21ARAF1.83728700
22EIF2AK11.80268897
23BCKDK1.79788630
24DAPK11.78878348
25MAP3K41.78284981
26PRPF4B1.72304881
27NEK11.70503436
28WNK41.69432774
29SIK31.68558825
30VRK11.64837359
31SGK21.62316604
32INSRR1.58840852
33TXK1.58522970
34MKNK21.49278513
35DYRK21.43045810
36NTRK31.39765435
37BRAF1.38036130
38EPHA41.37114898
39CAMKK21.36989373
40FGFR21.35772579
41TAOK21.35398545
42BRSK11.33052666
43SGK4941.32985250
44SGK2231.32985250
45TNIK1.31194401
46PLK41.30906702
47PLK31.30766670
48CDC71.29933586
49VRK21.26487760
50DAPK21.26217278
51STK391.23552269
52MARK11.22371285
53TRIM281.20693349
54CSNK1G31.18538213
55CSNK1G21.18231777
56PNCK1.16389658
57WEE11.15091111
58MINK11.12537016
59ADRBK11.12134744
60MKNK11.11418597
61EIF2AK31.10451282
62CSNK1G11.05261258
63PINK11.04403289
64SRPK11.03815411
65PRKCG0.97313133
66NTRK20.97168664
67MAPK130.94940979
68PRKD30.94914089
69CSNK1A1L0.94098995
70OXSR10.92044024
71YES10.89524978
72BRSK20.84560149
73BMPR20.84274649
74NME10.83892423
75SGK30.81000748
76WNK30.80995076
77NEK60.80022857
78GRK50.79559820
79MUSK0.79184717
80MST40.77464572
81PIK3CA0.74655562
82IKBKB0.72085415
83PIM20.71145005
84MAP2K40.68992389
85KIT0.67631173
86MAPK70.67441859
87TIE10.64814996
88TGFBR10.64254341
89CDK30.64078035
90CSNK1A10.60952357
91PHKG20.58954696
92PHKG10.58954696
93GRK70.57773517
94RPS6KB10.56814441
95TAF10.56657531
96PAK30.56562858
97PLK10.55866998
98MAP3K90.55791029
99ADRBK20.54673639
100RPS6KA50.53277231
101RIPK40.52850759
102EPHB20.51564127
103MAPKAPK50.51271567
104ERBB30.50732800
105AURKA0.50646161
106CDK50.50474992
107PKN10.49521042
108CDK180.48639389
109ATR0.48034623
110MAPKAPK30.47563709
111RPS6KA60.47488472
112GRK10.46080676
113MAP3K130.45659340
114MAPK150.44846410
115PRKCQ0.44814061
116CSNK1D0.44685758
117DYRK30.44047396
118PRKCE0.44040200
119SGK10.43910584
120TESK20.43439253
121ERBB40.43151020
122TEC0.41812408
123BCR0.40058710
124CAMK2A0.39800995
125PASK0.39689085
126STK30.38655025
127BMPR1B0.38438266
128OBSCN0.38315435
129PRKCI0.38071356
130STK110.38071160
131CDK150.36937843
132CDK140.36775886
133STK240.36549810
134CHUK0.35134887
135PRKCA0.35116641
136STK38L0.34984961
137CAMK2B0.34895831
138CSNK2A10.34170321
139ATM0.33502318
140LMTK20.28893266
141CHEK20.28136883
142MOS0.27084105
143CAMKK10.26343610
144PRKACA0.26035303
145EIF2AK20.25675655
146ZAK0.25196695
147RPS6KC10.25169633

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049663.97617147
2Synaptic vesicle cycle_Homo sapiens_hsa047213.85872323
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.66263963
4Nicotine addiction_Homo sapiens_hsa050333.22634621
5Vitamin B6 metabolism_Homo sapiens_hsa007503.21804214
6Proteasome_Homo sapiens_hsa030502.70845472
7Sulfur metabolism_Homo sapiens_hsa009202.40585045
8RNA polymerase_Homo sapiens_hsa030202.35867225
9Oxidative phosphorylation_Homo sapiens_hsa001902.25299502
10Vibrio cholerae infection_Homo sapiens_hsa051102.13566639
11GABAergic synapse_Homo sapiens_hsa047272.10430460
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.06658094
13Circadian rhythm_Homo sapiens_hsa047102.02816221
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90370623
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.86643113
16Olfactory transduction_Homo sapiens_hsa047401.84844144
17Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82316170
18Linoleic acid metabolism_Homo sapiens_hsa005911.81079781
19Morphine addiction_Homo sapiens_hsa050321.79514723
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.67366620
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.66890649
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.66329663
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63682179
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63422336
25Tryptophan metabolism_Homo sapiens_hsa003801.59599092
26Nitrogen metabolism_Homo sapiens_hsa009101.59152089
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58417656
28Parkinsons disease_Homo sapiens_hsa050121.56785046
29Selenocompound metabolism_Homo sapiens_hsa004501.56132870
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.56083062
31Pyruvate metabolism_Homo sapiens_hsa006201.54567450
32Circadian entrainment_Homo sapiens_hsa047131.52001636
33DNA replication_Homo sapiens_hsa030301.51593198
34Basal transcription factors_Homo sapiens_hsa030221.50954015
35Phototransduction_Homo sapiens_hsa047441.42153792
36Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.40998017
37Amphetamine addiction_Homo sapiens_hsa050311.40768022
38Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38245220
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.37966386
40Regulation of autophagy_Homo sapiens_hsa041401.33510413
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33344124
42Biosynthesis of amino acids_Homo sapiens_hsa012301.32244517
43Huntingtons disease_Homo sapiens_hsa050161.29408211
44Mismatch repair_Homo sapiens_hsa034301.28095940
45Rheumatoid arthritis_Homo sapiens_hsa053231.24903553
46Purine metabolism_Homo sapiens_hsa002301.22800132
47Carbon metabolism_Homo sapiens_hsa012001.21507641
48Caffeine metabolism_Homo sapiens_hsa002321.21005748
49Peroxisome_Homo sapiens_hsa041461.19827405
50Ribosome_Homo sapiens_hsa030101.18683407
51Retinol metabolism_Homo sapiens_hsa008301.17036371
52Taste transduction_Homo sapiens_hsa047421.15948058
53Ether lipid metabolism_Homo sapiens_hsa005651.15862313
54Insulin secretion_Homo sapiens_hsa049111.13687489
55Pyrimidine metabolism_Homo sapiens_hsa002401.10669624
56Chemical carcinogenesis_Homo sapiens_hsa052041.09968382
57Glutamatergic synapse_Homo sapiens_hsa047241.07901489
58Spliceosome_Homo sapiens_hsa030401.07453840
59Base excision repair_Homo sapiens_hsa034101.06956237
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06547382
61Fructose and mannose metabolism_Homo sapiens_hsa000511.06384527
62Cell cycle_Homo sapiens_hsa041101.05716852
63Phagosome_Homo sapiens_hsa041451.04837680
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04813988
65Nucleotide excision repair_Homo sapiens_hsa034201.04065512
66Dopaminergic synapse_Homo sapiens_hsa047281.03365576
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.01579204
68RNA degradation_Homo sapiens_hsa030180.99800922
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98539758
70Glycerolipid metabolism_Homo sapiens_hsa005610.98305655
71Homologous recombination_Homo sapiens_hsa034400.97519179
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96281757
73Propanoate metabolism_Homo sapiens_hsa006400.96180971
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.96026991
75One carbon pool by folate_Homo sapiens_hsa006700.95264014
76Alzheimers disease_Homo sapiens_hsa050100.93670809
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92737949
78Long-term potentiation_Homo sapiens_hsa047200.92700791
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92434903
80Type I diabetes mellitus_Homo sapiens_hsa049400.92156815
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.91786443
82Oocyte meiosis_Homo sapiens_hsa041140.91715682
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91045652
84RNA transport_Homo sapiens_hsa030130.89910574
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.89141152
86Cocaine addiction_Homo sapiens_hsa050300.86813166
87Butanoate metabolism_Homo sapiens_hsa006500.82821636
88Primary immunodeficiency_Homo sapiens_hsa053400.82463947
89Fatty acid elongation_Homo sapiens_hsa000620.81936735
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81908950
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81695807
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79612759
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79294144
94Serotonergic synapse_Homo sapiens_hsa047260.78707778
95Pentose phosphate pathway_Homo sapiens_hsa000300.76954588
96Fanconi anemia pathway_Homo sapiens_hsa034600.69814972
97Fat digestion and absorption_Homo sapiens_hsa049750.68689606
98Protein export_Homo sapiens_hsa030600.67540710
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.67248546
100Arachidonic acid metabolism_Homo sapiens_hsa005900.65187967
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64689953
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64425057
103Basal cell carcinoma_Homo sapiens_hsa052170.63299842
104Non-homologous end-joining_Homo sapiens_hsa034500.62027609
105Vitamin digestion and absorption_Homo sapiens_hsa049770.59007004
106Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57270125
107Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55958227
108Calcium signaling pathway_Homo sapiens_hsa040200.55023156
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53237064
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51996944
111Folate biosynthesis_Homo sapiens_hsa007900.49980597
112mRNA surveillance pathway_Homo sapiens_hsa030150.49257713
113Glucagon signaling pathway_Homo sapiens_hsa049220.48144515
114Epstein-Barr virus infection_Homo sapiens_hsa051690.47969902
115beta-Alanine metabolism_Homo sapiens_hsa004100.46758778
116p53 signaling pathway_Homo sapiens_hsa041150.45266593
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44782094
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44602172
119Metabolic pathways_Homo sapiens_hsa011000.44577346
120Histidine metabolism_Homo sapiens_hsa003400.44550032
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43912287
122Salivary secretion_Homo sapiens_hsa049700.42099514
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39212288
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38923166
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38557594
126Alcoholism_Homo sapiens_hsa050340.38200733
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.37444789
128Asthma_Homo sapiens_hsa053100.37105347
129Long-term depression_Homo sapiens_hsa047300.35001244
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34581295
131Cholinergic synapse_Homo sapiens_hsa047250.33617091
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32926381
133Legionellosis_Homo sapiens_hsa051340.30627493
134Gastric acid secretion_Homo sapiens_hsa049710.28970661
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27697862
136Oxytocin signaling pathway_Homo sapiens_hsa049210.27517857
137Fatty acid biosynthesis_Homo sapiens_hsa000610.24985977
138Renin secretion_Homo sapiens_hsa049240.24081843
139Cardiac muscle contraction_Homo sapiens_hsa042600.24043466
140Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23635241
141Fatty acid metabolism_Homo sapiens_hsa012120.20175593
142N-Glycan biosynthesis_Homo sapiens_hsa005100.17933221
143Sulfur relay system_Homo sapiens_hsa041220.17822221

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