LIN28B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* pre-miRNA processing (GO:0031054)5.40013317
2nuclear pore organization (GO:0006999)5.36730706
3nuclear pore complex assembly (GO:0051292)5.15459338
4regulation of posttranscriptional gene silencing (GO:0060147)4.81079784
5regulation of gene silencing by miRNA (GO:0060964)4.81079784
6regulation of gene silencing by RNA (GO:0060966)4.81079784
7DNA unwinding involved in DNA replication (GO:0006268)4.75213498
8DNA replication-dependent nucleosome assembly (GO:0006335)4.53774646
9DNA replication-dependent nucleosome organization (GO:0034723)4.53774646
10mitotic sister chromatid cohesion (GO:0007064)4.51909544
11paraxial mesoderm development (GO:0048339)4.45670413
12mitotic metaphase plate congression (GO:0007080)4.36294646
13kinetochore organization (GO:0051383)4.35825170
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.35523455
15protein localization to kinetochore (GO:0034501)4.04132612
16kinetochore assembly (GO:0051382)4.00187882
17metaphase plate congression (GO:0051310)3.97999897
18mitotic nuclear envelope disassembly (GO:0007077)3.91616170
19regulation of centriole replication (GO:0046599)3.90894311
20DNA replication initiation (GO:0006270)3.90124344
21L-serine metabolic process (GO:0006563)3.80014851
22pore complex assembly (GO:0046931)3.77771132
23regulation of sister chromatid cohesion (GO:0007063)3.75351555
24chromatin remodeling at centromere (GO:0031055)3.73031261
25heterochromatin organization (GO:0070828)3.69855548
26mitotic sister chromatid segregation (GO:0000070)3.69335861
27membrane disassembly (GO:0030397)3.67501962
28nuclear envelope disassembly (GO:0051081)3.67501962
29regulation of centrosome cycle (GO:0046605)3.66553385
30CENP-A containing nucleosome assembly (GO:0034080)3.65758510
31DNA replication-independent nucleosome assembly (GO:0006336)3.63877374
32DNA replication-independent nucleosome organization (GO:0034724)3.63877374
33histone exchange (GO:0043486)3.63478564
34ribosome assembly (GO:0042255)3.61212859
35regulation of histone H3-K9 methylation (GO:0051570)3.59615433
36DNA replication checkpoint (GO:0000076)3.58502947
37mitotic chromosome condensation (GO:0007076)3.55932248
38negative regulation of chromosome segregation (GO:0051985)3.55287677
39sister chromatid segregation (GO:0000819)3.55026328
40negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.52707517
41negative regulation of sister chromatid segregation (GO:0033046)3.52707517
42negative regulation of mitotic sister chromatid separation (GO:2000816)3.52707517
43negative regulation of mitotic sister chromatid segregation (GO:0033048)3.52707517
44negative regulation of histone methylation (GO:0031061)3.52175853
45DNA strand elongation involved in DNA replication (GO:0006271)3.50514901
46regulation of helicase activity (GO:0051095)3.49465549
47spindle checkpoint (GO:0031577)3.49196663
48spindle assembly checkpoint (GO:0071173)3.47994505
49regulation of mitotic metaphase/anaphase transition (GO:0030071)3.47796341
50positive regulation of chromosome segregation (GO:0051984)3.46459232
51regulation of chromosome segregation (GO:0051983)3.46011743
52protein localization to chromosome, centromeric region (GO:0071459)3.45080940
53mitotic spindle assembly checkpoint (GO:0007094)3.44961386
54IMP biosynthetic process (GO:0006188)3.44953655
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.44899124
56positive regulation of SMAD protein import into nucleus (GO:0060391)3.44865110
57attachment of spindle microtubules to kinetochore (GO:0008608)3.43074072
58mitotic spindle checkpoint (GO:0071174)3.42408687
59nucleobase biosynthetic process (GO:0046112)3.42005804
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.41874200
61establishment of chromosome localization (GO:0051303)3.41595832
62peptidyl-arginine omega-N-methylation (GO:0035247)3.39930957
63regulation of spindle organization (GO:0090224)3.38891025
64DNA topological change (GO:0006265)3.38730530
65regulation of sister chromatid segregation (GO:0033045)3.38439401
66regulation of mitotic sister chromatid separation (GO:0010965)3.38439401
67regulation of mitotic sister chromatid segregation (GO:0033047)3.38439401
68microtubule depolymerization (GO:0007019)3.37516012
69chromatin assembly or disassembly (GO:0006333)3.35723918
70non-recombinational repair (GO:0000726)3.35589162
71double-strand break repair via nonhomologous end joining (GO:0006303)3.35589162
72establishment of viral latency (GO:0019043)3.35310146
73establishment of integrated proviral latency (GO:0075713)3.34791590
74DNA strand elongation (GO:0022616)3.32369469
75positive regulation of mitotic sister chromatid separation (GO:1901970)3.31096136
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31096136
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31096136
78DNA geometric change (GO:0032392)3.30757157
79DNA duplex unwinding (GO:0032508)3.30298294
80DNA ligation (GO:0006266)3.29419498
81chromatin assembly (GO:0031497)3.25825224
82regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25105073
83ATP-dependent chromatin remodeling (GO:0043044)3.22788776
84regulation of centrosome duplication (GO:0010824)3.21083286
85purine nucleobase biosynthetic process (GO:0009113)3.20597838
86regulation of RNA export from nucleus (GO:0046831)3.20138491
87meiotic chromosome segregation (GO:0045132)3.19158748
88somatic diversification of immune receptors via somatic mutation (GO:0002566)3.17111827
89negative regulation of DNA repair (GO:0045738)3.14232973
90histone arginine methylation (GO:0034969)3.11922058
91DNA double-strand break processing (GO:0000729)3.08354102
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07267851
93regulation of mitotic spindle checkpoint (GO:1903504)3.07267851
94negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.05489737
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.04674255
96DNA strand renaturation (GO:0000733)3.03285153
97regulation of gene silencing (GO:0060968)3.02213631
98peptidyl-arginine N-methylation (GO:0035246)3.02145085
99peptidyl-arginine methylation (GO:0018216)3.02145085
100negative regulation of DNA-dependent DNA replication (GO:2000104)3.01480620
101mitotic G2/M transition checkpoint (GO:0044818)3.01139437
102folic acid-containing compound biosynthetic process (GO:0009396)3.00126735
103regulation of mitotic spindle organization (GO:0060236)2.99825877
104DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.97896728
105DNA damage response, detection of DNA damage (GO:0042769)2.97428590
106protein K6-linked ubiquitination (GO:0085020)2.96859205
107IMP metabolic process (GO:0046040)2.96495515
108negative regulation of DNA recombination (GO:0045910)2.96368287
109telomere maintenance via semi-conservative replication (GO:0032201)2.96268897
110negative regulation of translation, ncRNA-mediated (GO:0040033)2.93089594
111regulation of translation, ncRNA-mediated (GO:0045974)2.93089594
112negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93089594
113mRNA transport (GO:0051028)2.93087123
114protein localization to chromosome (GO:0034502)2.91881722
115intra-S DNA damage checkpoint (GO:0031573)2.91205988
116chromosome segregation (GO:0007059)2.90162033
117mitotic recombination (GO:0006312)2.88958142
118protein complex localization (GO:0031503)2.88376118
119somatic hypermutation of immunoglobulin genes (GO:0016446)2.87208576
120negative regulation of mitosis (GO:0045839)2.86421276
121formation of translation preinitiation complex (GO:0001731)2.74635162
122telomere maintenance via recombination (GO:0000722)2.74609903
123negative regulation of RNA splicing (GO:0033119)2.71238762
124negative regulation of mRNA processing (GO:0050686)2.68155500
125replication fork processing (GO:0031297)2.67690627
126nucleosome disassembly (GO:0006337)2.64830657
127protein-DNA complex disassembly (GO:0032986)2.64830657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.50493234
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.60894451
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.17524152
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56956284
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07542711
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03736797
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.79937373
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.76508461
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74140190
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.47842696
11AR_21909140_ChIP-Seq_LNCAP_Human2.45604062
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35802139
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.26300820
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.25256804
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.24590978
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.22858694
17MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.21531870
18XRN2_22483619_ChIP-Seq_HELA_Human2.15413021
19EST1_17652178_ChIP-ChIP_JURKAT_Human2.14048133
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.08009559
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07380249
22MYCN_18555785_ChIP-Seq_MESCs_Mouse2.01291353
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.01140616
24E2F7_22180533_ChIP-Seq_HELA_Human10.4971640
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.99791570
26POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93339761
27* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.90847937
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.90605025
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.88388467
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.87660544
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.86091619
32* TTF2_22483619_ChIP-Seq_HELA_Human1.82906553
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79191468
34ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.66703851
35POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.63688060
36NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60546846
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60147524
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60147524
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60147524
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58529335
41VDR_23849224_ChIP-Seq_CD4+_Human1.57895038
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.57622367
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56376562
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55139311
45HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53848385
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52117510
47JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49697115
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46036587
49EWS_26573619_Chip-Seq_HEK293_Human1.45932754
50FOXP3_21729870_ChIP-Seq_TREG_Human1.43870399
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43477421
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43113097
53CIITA_25753668_ChIP-Seq_RAJI_Human1.42693937
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.42454168
55KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.42172679
56TCF3_18692474_ChIP-Seq_MEFs_Mouse1.40957379
57ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40311639
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37554060
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36180316
60* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.35940314
61NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35783535
62NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34684860
63SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32554198
64GABP_19822575_ChIP-Seq_HepG2_Human1.30261911
65KDM5A_27292631_Chip-Seq_BREAST_Human1.29983164
66NANOG_21062744_ChIP-ChIP_HESCs_Human1.29378614
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.29373557
68ELK1_19687146_ChIP-ChIP_HELA_Human1.29317088
69* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29148982
70CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25791204
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25648875
72* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23186030
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21755855
74NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21368753
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20626312
76DCP1A_22483619_ChIP-Seq_HELA_Human1.18869961
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13561328
78MYC_18940864_ChIP-ChIP_HL60_Human1.12793348
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.10451010
80MYC_22102868_ChIP-Seq_BL_Human1.08288811
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07266174
82SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.05762382
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04689335
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04292830
85VDR_22108803_ChIP-Seq_LS180_Human1.03833598
86IRF1_19129219_ChIP-ChIP_H3396_Human1.03436592
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03400538
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.00477796
89YY1_21170310_ChIP-Seq_MESCs_Mouse0.99597065
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98972631
91POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98630593
92ZNF274_21170338_ChIP-Seq_K562_Hela0.98507713
93SOX17_20123909_ChIP-Seq_XEN_Mouse0.98342646
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.97816009
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.96129692
96POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93330128
97SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92693235
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92061021
99IGF1R_20145208_ChIP-Seq_DFB_Human0.89991658
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89543774
101PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88838378
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88618881
103HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88246277
104TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.87896390
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87172294
106FUS_26573619_Chip-Seq_HEK293_Human0.86744599
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86270123
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.85918781
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85838501
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80994420
111PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80439025
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80194188
113TBX3_20139965_ChIP-Seq_ESCs_Mouse0.80092344
114TBX3_20139965_ChIP-Seq_MESCs_Mouse0.79399284
115P300_19829295_ChIP-Seq_ESCs_Human0.79253414

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.04036532
2MP0003111_abnormal_nucleus_morphology3.77738963
3MP0003693_abnormal_embryo_hatching3.76637844
4MP0008057_abnormal_DNA_replication3.49890244
5MP0004957_abnormal_blastocyst_morpholog3.41911325
6MP0003123_paternal_imprinting3.41123669
7MP0003077_abnormal_cell_cycle3.31867560
8MP0008877_abnormal_DNA_methylation2.96440111
9MP0003121_genomic_imprinting2.84274600
10MP0008058_abnormal_DNA_repair2.82455130
11MP0010030_abnormal_orbit_morphology2.78506828
12MP0003890_abnormal_embryonic-extraembry2.67704548
13MP0006292_abnormal_olfactory_placode2.64166951
14MP0008932_abnormal_embryonic_tissue2.39524486
15MP0000537_abnormal_urethra_morphology2.26583547
16MP0001730_embryonic_growth_arrest2.23367389
17MP0003122_maternal_imprinting2.18597519
18MP0008007_abnormal_cellular_replicative2.11130310
19MP0001293_anophthalmia2.10764513
20MP0000350_abnormal_cell_proliferation2.05978997
21MP0002084_abnormal_developmental_patter2.02197382
22MP0005380_embryogenesis_phenotype1.95808695
23MP0001672_abnormal_embryogenesis/_devel1.95808695
24MP0002085_abnormal_embryonic_tissue1.92019666
25MP0009053_abnormal_anal_canal1.89462255
26MP0003119_abnormal_digestive_system1.89127832
27MP0003937_abnormal_limbs/digits/tail_de1.85335368
28MP0001697_abnormal_embryo_size1.83873625
29MP0002653_abnormal_ependyma_morphology1.79658788
30MP0004197_abnormal_fetal_growth/weight/1.76410166
31MP0010307_abnormal_tumor_latency1.70298482
32MP0003941_abnormal_skin_development1.69644801
33MP0003984_embryonic_growth_retardation1.69605608
34MP0010352_gastrointestinal_tract_polyps1.68283294
35MP0001188_hyperpigmentation1.67307060
36MP0002088_abnormal_embryonic_growth/wei1.65750555
37MP0009672_abnormal_birth_weight1.64456552
38MP0003136_yellow_coat_color1.61207559
39MP0002254_reproductive_system_inflammat1.59560602
40MP0003567_abnormal_fetal_cardiomyocyte1.57558299
41MP0003315_abnormal_perineum_morphology1.55137959
42MP0000566_synostosis1.52687537
43MP0004133_heterotaxia1.52544397
44MP0005076_abnormal_cell_differentiation1.50738943
45MP0002086_abnormal_extraembryonic_tissu1.44847150
46MP0002080_prenatal_lethality1.40478002
47MP0002210_abnormal_sex_determination1.36112078
48MP0005084_abnormal_gallbladder_morpholo1.34552815
49MP0002938_white_spotting1.33724434
50MP0001286_abnormal_eye_development1.33079952
51MP0003861_abnormal_nervous_system1.31497031
52MP0003786_premature_aging1.30189857
53MP0002697_abnormal_eye_size1.30145358
54MP0009703_decreased_birth_body1.27126765
55MP0002102_abnormal_ear_morphology1.25702329
56MP0002249_abnormal_larynx_morphology1.23993805
57MP0003938_abnormal_ear_development1.21398771
58MP0002111_abnormal_tail_morphology1.20389419
59MP0001299_abnormal_eye_distance/1.19359462
60MP0008789_abnormal_olfactory_epithelium1.17547288
61MP0000428_abnormal_craniofacial_morphol1.16858366
62MP0000049_abnormal_middle_ear1.15902095
63MP0001145_abnormal_male_reproductive1.15664264
64MP0006072_abnormal_retinal_apoptosis1.13126221
65MP0002092_abnormal_eye_morphology1.09212051
66MP0003718_maternal_effect1.08357781
67MP0009697_abnormal_copulation1.07283993
68MP0003935_abnormal_craniofacial_develop1.07132473
69MP0003385_abnormal_body_wall1.06717367
70MP0001929_abnormal_gametogenesis1.06648350
71MP0003283_abnormal_digestive_organ1.06462318
72MP0005394_taste/olfaction_phenotype1.06426168
73MP0005499_abnormal_olfactory_system1.06426168
74MP0000432_abnormal_head_morphology1.05170783
75MP0000653_abnormal_sex_gland1.03689258
76MP0002160_abnormal_reproductive_system1.02041886
77MP0000313_abnormal_cell_death0.99718035
78MP0003787_abnormal_imprinting0.98865282
79MP0002233_abnormal_nose_morphology0.97646339
80MP0005248_abnormal_Harderian_gland0.97048521
81MP0002932_abnormal_joint_morphology0.95789412
82MP0008995_early_reproductive_senescence0.95338485
83MP0003755_abnormal_palate_morphology0.94824077
84MP0003115_abnormal_respiratory_system0.93988817
85MP0005377_hearing/vestibular/ear_phenot0.92219659
86MP0003878_abnormal_ear_physiology0.92219659
87MP0001346_abnormal_lacrimal_gland0.89140593
88MP0002116_abnormal_craniofacial_bone0.87363186
89MP0004233_abnormal_muscle_weight0.85759526
90MP0002751_abnormal_autonomic_nervous0.85444519
91MP0002114_abnormal_axial_skeleton0.83439637
92MP0001529_abnormal_vocalization0.78656761
93MP0003698_abnormal_male_reproductive0.78240062
94MP0000647_abnormal_sebaceous_gland0.77763227
95MP0006276_abnormal_autonomic_nervous0.76763207
96MP0005187_abnormal_penis_morphology0.76234273
97MP0000516_abnormal_urinary_system0.74825567
98MP0005367_renal/urinary_system_phenotyp0.74825567
99MP0002081_perinatal_lethality0.73568600
100MP0006035_abnormal_mitochondrial_morpho0.73334606
101MP0001119_abnormal_female_reproductive0.71988449
102MP0002925_abnormal_cardiovascular_devel0.69901624
103MP0000778_abnormal_nervous_system0.69255801
104MP0001915_intracranial_hemorrhage0.68282972
105MP0001177_atelectasis0.67251409
106MP0000955_abnormal_spinal_cord0.66798283
107MP0000490_abnormal_crypts_of0.66434320
108MP0003942_abnormal_urinary_system0.65501391
109MP0002184_abnormal_innervation0.65465720
110MP0003880_abnormal_central_pattern0.65355324
111MP0005391_vision/eye_phenotype0.65238851
112MP0002282_abnormal_trachea_morphology0.65141865
113MP0003705_abnormal_hypodermis_morpholog0.64693775
114MP0000579_abnormal_nail_morphology0.64170202
115MP0002152_abnormal_brain_morphology0.63836820
116MP0005389_reproductive_system_phenotype0.62827966
117MP0002019_abnormal_tumor_incidence0.62034518
118MP0000631_abnormal_neuroendocrine_gland0.61368914

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.14206725
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.05271424
3Medulloblastoma (HP:0002885)3.81910877
4Abnormality of the labia minora (HP:0012880)3.60391804
5Hepatoblastoma (HP:0002884)3.58339245
6Cortical dysplasia (HP:0002539)3.57400269
7Colon cancer (HP:0003003)3.50111219
8Ependymoma (HP:0002888)3.49572218
9Birth length less than 3rd percentile (HP:0003561)3.25360743
10Supernumerary spleens (HP:0009799)3.23084083
11Ectopic kidney (HP:0000086)3.15652342
12Abnormal lung lobation (HP:0002101)2.97443386
13Rhabdomyosarcoma (HP:0002859)2.95480858
14Abnormal number of incisors (HP:0011064)2.94583978
15Increased nuchal translucency (HP:0010880)2.93849911
16Abnormality of chromosome stability (HP:0003220)2.87002498
17Septo-optic dysplasia (HP:0100842)2.84011705
18Absent radius (HP:0003974)2.83799215
19Meckel diverticulum (HP:0002245)2.83356873
20Patellar aplasia (HP:0006443)2.75962504
21Volvulus (HP:0002580)2.75000857
22Short 4th metacarpal (HP:0010044)2.73227908
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.73227908
24Abnormality of the astrocytes (HP:0100707)2.72526209
25Astrocytoma (HP:0009592)2.72526209
26Aplasia/Hypoplasia of the uvula (HP:0010293)2.71100210
27Abnormality of the ileum (HP:0001549)2.68048298
28Aplasia involving forearm bones (HP:0009822)2.67408474
29Absent forearm bone (HP:0003953)2.67408474
30High anterior hairline (HP:0009890)2.66624855
31Neoplasm of striated muscle (HP:0009728)2.63052280
32Renal duplication (HP:0000075)2.60596985
33Nephroblastoma (Wilms tumor) (HP:0002667)2.60245081
34Aplasia/Hypoplasia of the patella (HP:0006498)2.59165189
35Reticulocytopenia (HP:0001896)2.52825474
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.51932379
37Selective tooth agenesis (HP:0001592)2.48353719
38Carpal bone hypoplasia (HP:0001498)2.46620640
39Small intestinal stenosis (HP:0012848)2.46116010
40Duodenal stenosis (HP:0100867)2.46116010
41Embryonal renal neoplasm (HP:0011794)2.45072234
42Glioma (HP:0009733)2.44581373
43Abnormality of the preputium (HP:0100587)2.42945472
44Impulsivity (HP:0100710)2.41280724
45Facial hemangioma (HP:0000329)2.38331570
46Hyperglycinemia (HP:0002154)2.37318370
47Neoplasm of the oral cavity (HP:0100649)2.36156687
48Abnormality of abdominal situs (HP:0011620)2.35511547
49Abdominal situs inversus (HP:0003363)2.35511547
50Breast hypoplasia (HP:0003187)2.34308234
51Rib fusion (HP:0000902)2.33967216
52Pancreatic islet-cell hyperplasia (HP:0004510)2.30240376
53Horseshoe kidney (HP:0000085)2.29594262
54Proximal placement of thumb (HP:0009623)2.28079326
55Stenosis of the external auditory canal (HP:0000402)2.27276209
56Abnormality of the carotid arteries (HP:0005344)2.24979314
57Esophageal atresia (HP:0002032)2.24664152
58Supernumerary ribs (HP:0005815)2.24557877
59Absent thumb (HP:0009777)2.23646236
60Atresia of the external auditory canal (HP:0000413)2.21679853
61Agnosia (HP:0010524)2.20531012
62Abnormality of the duodenum (HP:0002246)2.20455505
63Oligodactyly (HP:0012165)2.20114339
64Spastic diplegia (HP:0001264)2.18661776
65Deviation of the thumb (HP:0009603)2.18093017
66Supernumerary bones of the axial skeleton (HP:0009144)2.16440801
67Myelomeningocele (HP:0002475)2.15986941
68Intestinal atresia (HP:0011100)2.15492022
69Abnormality of cochlea (HP:0000375)2.13021765
70Duplicated collecting system (HP:0000081)2.10921239
71Biliary tract neoplasm (HP:0100574)2.08385698
72Multiple enchondromatosis (HP:0005701)2.08056624
73Rectovaginal fistula (HP:0000143)2.07941822
74Rectal fistula (HP:0100590)2.07941822
75Tracheoesophageal fistula (HP:0002575)2.05757943
76Oral leukoplakia (HP:0002745)2.02404487
77Aplasia/hypoplasia of the humerus (HP:0006507)2.01288203
78Absent septum pellucidum (HP:0001331)2.00756611
79Breast aplasia (HP:0100783)2.00587210
80Abnormality of the septum pellucidum (HP:0007375)2.00346927
81Duplication of thumb phalanx (HP:0009942)2.00288653
82Choanal stenosis (HP:0000452)1.98497360
83Shoulder girdle muscle weakness (HP:0003547)1.97708015
84Diastasis recti (HP:0001540)1.97095737
85Short thumb (HP:0009778)1.96510487
86Sloping forehead (HP:0000340)1.96292102
87Anal stenosis (HP:0002025)1.96241636
88Skull defect (HP:0001362)1.96110722
89Facial cleft (HP:0002006)1.94656128
90Triphalangeal thumb (HP:0001199)1.94497405
91Neoplasm of the pancreas (HP:0002894)1.93804602
92Abnormality of the 4th metacarpal (HP:0010012)1.93639272
93Long eyelashes (HP:0000527)1.89554795
94Irregular epiphyses (HP:0010582)1.89039056
95Gastrointestinal carcinoma (HP:0002672)1.88402720
96Malignant gastrointestinal tract tumors (HP:0006749)1.88402720
97Abnormality of the diencephalon (HP:0010662)1.88394223
98Partial duplication of thumb phalanx (HP:0009944)1.87923718
99Pelvic girdle muscle weakness (HP:0003749)1.86710497
100Embryonal neoplasm (HP:0002898)1.84829669
101Neoplasm of the adrenal cortex (HP:0100641)1.84774732
102Intestinal fistula (HP:0100819)1.84724490
103Vaginal fistula (HP:0004320)1.83550962
104Aplasia/Hypoplasia of the breasts (HP:0010311)1.83510581
105Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83427881
106Cafe-au-lait spot (HP:0000957)1.83356063
107Shawl scrotum (HP:0000049)1.82796626
108Short humerus (HP:0005792)1.81801913
109Trigonocephaly (HP:0000243)1.81716327
110Anophthalmia (HP:0000528)1.79573166
111Abnormality of the renal collecting system (HP:0004742)1.79459346
112Bilateral microphthalmos (HP:0007633)1.77650563
113Myelodysplasia (HP:0002863)1.77364556
114Degeneration of anterior horn cells (HP:0002398)1.77117241
115Abnormality of the anterior horn cell (HP:0006802)1.77117241
116Overlapping toe (HP:0001845)1.76657814
117Gastrointestinal atresia (HP:0002589)1.76489473
118Bifid tongue (HP:0010297)1.76357897
119Papillary thyroid carcinoma (HP:0002895)1.76158454
120Homocystinuria (HP:0002156)1.75864694
121Abnormality of homocysteine metabolism (HP:0010919)1.75864694
122Missing ribs (HP:0000921)1.74736163
123Bicornuate uterus (HP:0000813)1.74699805
124Absent eyebrow (HP:0002223)1.74372036
125Renovascular hypertension (HP:0100817)1.72915074
126Broad thumb (HP:0011304)1.72869241
127Abnormal hair whorl (HP:0010721)1.71539841
128Preaxial foot polydactyly (HP:0001841)1.68264561
129Maternal diabetes (HP:0009800)1.67671570
130Neoplasm of the colon (HP:0100273)1.66792130
131Cutaneous syndactyly (HP:0012725)1.66335882
132Omphalocele (HP:0001539)1.65933334
133Abnormality of serine family amino acid metabolism (HP:0010894)1.65845463
134Abnormality of glycine metabolism (HP:0010895)1.65845463
135Abnormality of serum amino acid levels (HP:0003112)1.65827875
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.65433480
137Hypoplastic female external genitalia (HP:0012815)1.64756409
138Hemivertebrae (HP:0002937)1.64694878
139Osteomalacia (HP:0002749)1.63245382
140Hyperglycinuria (HP:0003108)1.62966914
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61415732
142Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.61382247
143Dandy-Walker malformation (HP:0001305)1.59765610
144Cutaneous finger syndactyly (HP:0010554)1.59153233
145Renal hypoplasia (HP:0000089)1.57660006
146Macrocytic anemia (HP:0001972)1.56782367

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.45777969
2WEE13.42127222
3BUB13.30659538
4CDK123.14546354
5SRPK12.91593440
6MKNK12.84713947
7TSSK62.77629365
8NEK22.70602565
9TAF12.69352455
10TTK2.62440064
11PNCK2.44140447
12EIF2AK12.31823558
13PLK42.18333090
14PLK32.15003147
15TNIK2.12743317
16LATS22.11870226
17MKNK22.09888795
18NEK12.07230667
19LATS12.03290285
20BRD41.96066632
21PLK11.93920059
22ATR1.78217532
23ACVR1B1.78158761
24TRIM281.68707501
25CHEK21.67358097
26CDK71.63236364
27CHEK11.57410799
28VRK21.56434953
29DYRK31.50530192
30PASK1.49363518
31AURKB1.49081241
32ATM1.31720088
33STK38L1.31444022
34TLK11.30319419
35VRK11.27579044
36ALK1.20483588
37BRSK21.17570208
38RPS6KB21.16908746
39AURKA1.14704192
40NUAK11.14412576
41MAP3K81.14096517
42CDK41.12825418
43CDK21.09984243
44CDK191.09084358
45PAK41.08278103
46CASK1.07561066
47WNK31.07118101
48FGFR21.06056309
49BMPR1B1.04138039
50EPHA21.00981984
51CDK10.97001820
52CDK60.95853126
53STK240.95710550
54MAP3K100.95434032
55STK30.92264153
56KSR10.91768588
57FGFR10.90051245
58STK40.87882386
59BRSK10.87256080
60STK160.84567141
61EPHB20.83199520
62CSNK1E0.80809406
63NME10.78836494
64TGFBR10.77066891
65EIF2AK30.76408035
66BCR0.75612659
67MELK0.74288595
68RPS6KA40.71337749
69CSNK2A20.69787000
70MTOR0.69729670
71EEF2K0.69183242
72NTRK20.67474726
73CCNB10.65269809
74PRKDC0.63361942
75TYRO30.63033634
76CDK80.62615623
77EPHA40.61904327
78ZAK0.61567730
79CSNK1D0.61452160
80MAP3K90.60687178
81CSNK1G20.57358559
82MAP3K40.56255274
83MAP2K70.56005339
84MINK10.55787840
85AKT30.55104737
86TIE10.54119865
87AKT20.53586813
88BRAF0.52683848
89SMG10.52379607
90CSNK2A10.52166439
91DYRK20.51999734
92ERBB30.48830556
93MAPK140.47404264
94STK100.46591526
95GSK3B0.44770607
96CDK180.43923951
97CAMK1D0.43703351
98PLK20.43098646
99MAPK100.41956695
100CSNK1G30.41251266
101CDK150.41200373
102TESK20.40831806
103PDK40.40354283
104PDK30.40354283
105PBK0.40185267
106AKT10.39617901
107CDK30.39578563
108CDK11A0.39084649
109FLT30.38103975
110CDK140.36918779
111PAK10.36604654
112DYRK1A0.36532295
113ERBB40.36324000
114PRKCG0.36311180
115CSNK1A1L0.36118649
116ICK0.35835658
117OBSCN0.35822072
118CSNK1G10.35667479
119NLK0.34304447
120RPS6KA50.33477418
121MST40.32786652
122CDK90.31434297
123ERBB20.30554395
124EIF2AK20.29183337
125RPS6KB10.28450446
126MAP3K60.25789221
127CAMK1G0.25722342
128PRKCI0.25528984
129PIM10.24869405
130UHMK10.24105376
131CLK10.24032341

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.31972171
2Mismatch repair_Homo sapiens_hsa034304.14422201
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.86305242
4Spliceosome_Homo sapiens_hsa030403.75684882
5RNA transport_Homo sapiens_hsa030133.73093689
6Cell cycle_Homo sapiens_hsa041103.42050299
7Homologous recombination_Homo sapiens_hsa034402.87492649
8mRNA surveillance pathway_Homo sapiens_hsa030152.69540763
9RNA polymerase_Homo sapiens_hsa030202.68994311
10Nucleotide excision repair_Homo sapiens_hsa034202.68969417
11Fanconi anemia pathway_Homo sapiens_hsa034602.66887130
12Base excision repair_Homo sapiens_hsa034102.49726776
13One carbon pool by folate_Homo sapiens_hsa006702.45779764
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45688479
15RNA degradation_Homo sapiens_hsa030182.28784201
16Basal transcription factors_Homo sapiens_hsa030222.26794275
17Non-homologous end-joining_Homo sapiens_hsa034502.23976285
18Steroid biosynthesis_Homo sapiens_hsa001002.02746325
19Proteasome_Homo sapiens_hsa030501.99255881
20Basal cell carcinoma_Homo sapiens_hsa052171.93605268
21Pyrimidine metabolism_Homo sapiens_hsa002401.88478664
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.86524364
23Oocyte meiosis_Homo sapiens_hsa041141.84868153
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.79446278
25Ribosome_Homo sapiens_hsa030101.78573284
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.70158808
27Systemic lupus erythematosus_Homo sapiens_hsa053221.67004015
28Hedgehog signaling pathway_Homo sapiens_hsa043401.53235057
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50629943
30Pyruvate metabolism_Homo sapiens_hsa006201.49898811
31p53 signaling pathway_Homo sapiens_hsa041151.49651259
32Hippo signaling pathway_Homo sapiens_hsa043901.49615181
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.39897282
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36365318
35Protein export_Homo sapiens_hsa030601.33232381
36Propanoate metabolism_Homo sapiens_hsa006401.30271871
37MicroRNAs in cancer_Homo sapiens_hsa052061.24567449
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15118501
39Purine metabolism_Homo sapiens_hsa002301.09463197
40TGF-beta signaling pathway_Homo sapiens_hsa043501.06560993
41Parkinsons disease_Homo sapiens_hsa050121.05575237
42Epstein-Barr virus infection_Homo sapiens_hsa051691.03784051
43Alcoholism_Homo sapiens_hsa050341.03698588
44Viral carcinogenesis_Homo sapiens_hsa052031.01751114
45Wnt signaling pathway_Homo sapiens_hsa043100.99468942
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98755722
47Thyroid cancer_Homo sapiens_hsa052160.92485456
48HTLV-I infection_Homo sapiens_hsa051660.90633437
49Oxidative phosphorylation_Homo sapiens_hsa001900.85468467
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.84695669
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84507594
52Adherens junction_Homo sapiens_hsa045200.83224585
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81944620
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81710646
55Notch signaling pathway_Homo sapiens_hsa043300.81259883
56Herpes simplex infection_Homo sapiens_hsa051680.75907570
57Colorectal cancer_Homo sapiens_hsa052100.74165084
58Lysine degradation_Homo sapiens_hsa003100.72037211
59Tight junction_Homo sapiens_hsa045300.66615457
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65837508
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65021333
62Biosynthesis of amino acids_Homo sapiens_hsa012300.63112111
63mTOR signaling pathway_Homo sapiens_hsa041500.61311061
64Fatty acid elongation_Homo sapiens_hsa000620.61038578
65Arginine and proline metabolism_Homo sapiens_hsa003300.60914050
66Selenocompound metabolism_Homo sapiens_hsa004500.60077654
67Pathways in cancer_Homo sapiens_hsa052000.59940082
68Melanogenesis_Homo sapiens_hsa049160.56801318
69Fat digestion and absorption_Homo sapiens_hsa049750.56765987
70Fatty acid metabolism_Homo sapiens_hsa012120.55556686
71Vitamin digestion and absorption_Homo sapiens_hsa049770.53727568
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.52716034
73Folate biosynthesis_Homo sapiens_hsa007900.51520564
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48184532
75Metabolic pathways_Homo sapiens_hsa011000.47333526
76Sulfur relay system_Homo sapiens_hsa041220.46722907
77Vitamin B6 metabolism_Homo sapiens_hsa007500.46275164
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44783682
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42728441
80Prostate cancer_Homo sapiens_hsa052150.41276265
81Small cell lung cancer_Homo sapiens_hsa052220.40669469
82Melanoma_Homo sapiens_hsa052180.40426801
83Antigen processing and presentation_Homo sapiens_hsa046120.36494148
84Alzheimers disease_Homo sapiens_hsa050100.35319823
85Glutathione metabolism_Homo sapiens_hsa004800.34980885
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34840210
87Bladder cancer_Homo sapiens_hsa052190.34778560
88Arginine biosynthesis_Homo sapiens_hsa002200.33891999
89Olfactory transduction_Homo sapiens_hsa047400.33191965
90HIF-1 signaling pathway_Homo sapiens_hsa040660.33100300
91Proteoglycans in cancer_Homo sapiens_hsa052050.31962135
92Endometrial cancer_Homo sapiens_hsa052130.31653275
93Renal cell carcinoma_Homo sapiens_hsa052110.30241843
94Axon guidance_Homo sapiens_hsa043600.30159056
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30093345
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.29209536
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28930402
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28573964
99FoxO signaling pathway_Homo sapiens_hsa040680.28302297
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28251347
101Chronic myeloid leukemia_Homo sapiens_hsa052200.27703935
102Cardiac muscle contraction_Homo sapiens_hsa042600.27285706
103Viral myocarditis_Homo sapiens_hsa054160.26318057
104Fatty acid degradation_Homo sapiens_hsa000710.25715608
105Thyroid hormone synthesis_Homo sapiens_hsa049180.24193437
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24088910
107Dorso-ventral axis formation_Homo sapiens_hsa043200.23833044
108Fatty acid biosynthesis_Homo sapiens_hsa000610.23757565
109N-Glycan biosynthesis_Homo sapiens_hsa005100.23210623
110Phototransduction_Homo sapiens_hsa047440.22178389
111Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20451083
112Butanoate metabolism_Homo sapiens_hsa006500.20268624
113Pentose phosphate pathway_Homo sapiens_hsa000300.19375886
114Huntingtons disease_Homo sapiens_hsa050160.19160620
115Non-small cell lung cancer_Homo sapiens_hsa052230.18053333
116Glucagon signaling pathway_Homo sapiens_hsa049220.17213119
117Retinol metabolism_Homo sapiens_hsa008300.16680962
118Taste transduction_Homo sapiens_hsa047420.16365500
119Legionellosis_Homo sapiens_hsa051340.14926528
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14926062
121Gap junction_Homo sapiens_hsa045400.14872916
122Rap1 signaling pathway_Homo sapiens_hsa040150.14358524
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12950677
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.12945988
125Peroxisome_Homo sapiens_hsa041460.12892931
126Estrogen signaling pathway_Homo sapiens_hsa049150.12598049
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.12155246
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10457444
129Hepatitis B_Homo sapiens_hsa051610.10253982
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10180831
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.08752987
132Long-term potentiation_Homo sapiens_hsa047200.08412944
133ErbB signaling pathway_Homo sapiens_hsa040120.08373834
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.08315773
135MAPK signaling pathway_Homo sapiens_hsa040100.08079113
136AMPK signaling pathway_Homo sapiens_hsa041520.06887132
137Apoptosis_Homo sapiens_hsa042100.06686016
138Glioma_Homo sapiens_hsa052140.04876650
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.03838675
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.03237454
141Nicotine addiction_Homo sapiens_hsa050330.02694182
142Carbon metabolism_Homo sapiens_hsa012000.02448850
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.00078028
144Influenza A_Homo sapiens_hsa05164-0.0008901

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