LILRB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)6.00680453
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.00680453
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.84030960
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.84030960
5modulation by symbiont of host immune response (GO:0052553)5.84030960
6positive regulation by symbiont of host defense response (GO:0052509)5.84030960
7modulation by symbiont of host defense response (GO:0052031)5.84030960
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.84030960
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.65858867
10positive regulation of gamma-delta T cell activation (GO:0046645)5.56118125
11neutrophil activation involved in immune response (GO:0002283)5.55985065
12response to peptidoglycan (GO:0032494)5.29764365
13macrophage activation involved in immune response (GO:0002281)5.19976488
14detection of other organism (GO:0098543)5.10716711
15negative regulation of interleukin-12 production (GO:0032695)5.02610223
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.93717376
17antigen processing and presentation of endogenous antigen (GO:0019883)4.86153250
18detection of bacterium (GO:0016045)4.81738335
19leukocyte aggregation (GO:0070486)4.57164763
20detection of molecule of bacterial origin (GO:0032490)4.55397274
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.46120088
22detection of external biotic stimulus (GO:0098581)4.43337123
23cellular extravasation (GO:0045123)4.40181920
24regulation of B cell receptor signaling pathway (GO:0050855)4.35083659
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.30720758
26neutrophil activation (GO:0042119)4.28877762
27regulation of interferon-beta biosynthetic process (GO:0045357)4.28333096
28leukocyte migration involved in inflammatory response (GO:0002523)4.19926236
29immunoglobulin mediated immune response (GO:0016064)4.16881801
30respiratory burst (GO:0045730)4.07250082
31granulocyte activation (GO:0036230)4.06002612
32negative regulation of lymphocyte mediated immunity (GO:0002707)4.01166018
33regulation of gamma-delta T cell activation (GO:0046643)3.97550584
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96169447
35response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.95738268
36response to host immune response (GO:0052572)3.95738268
37detection of biotic stimulus (GO:0009595)3.92038058
38microglial cell activation (GO:0001774)3.90218882
39macrophage activation (GO:0042116)3.81585868
40myeloid cell activation involved in immune response (GO:0002275)3.76512456
41regulation of mast cell degranulation (GO:0043304)3.76125019
42type I interferon signaling pathway (GO:0060337)3.65093281
43cellular response to type I interferon (GO:0071357)3.65093281
44neutrophil mediated immunity (GO:0002446)3.62746234
45production of molecular mediator involved in inflammatory response (GO:0002532)3.61742960
46response to type I interferon (GO:0034340)3.61712474
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.60793663
48response to host (GO:0075136)3.60793663
49response to host defenses (GO:0052200)3.60793663
50negative regulation of leukocyte mediated immunity (GO:0002704)3.58402835
51negative regulation of T cell mediated immunity (GO:0002710)3.56036384
52lipopolysaccharide-mediated signaling pathway (GO:0031663)3.48891408
53regulation of mast cell activation involved in immune response (GO:0033006)3.47876547
54response to interleukin-15 (GO:0070672)3.47828902
55positive regulation of mast cell activation (GO:0033005)3.46373943
56germinal center formation (GO:0002467)3.46306285
57regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43611849
58regulation of T cell tolerance induction (GO:0002664)3.43204265
59defense response to protozoan (GO:0042832)3.41697712
60response to muramyl dipeptide (GO:0032495)3.41539362
61negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.40498124
62regulation of T-helper 2 cell differentiation (GO:0045628)3.35719166
63regulation of tolerance induction (GO:0002643)3.32923597
64interferon-gamma-mediated signaling pathway (GO:0060333)3.32768044
65regulation of leukocyte degranulation (GO:0043300)3.31950008
66regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30653064
67regulation of mast cell activation (GO:0033003)3.29844981
68negative regulation of cytokine production involved in immune response (GO:0002719)3.24163671
69B cell mediated immunity (GO:0019724)3.23533565
70regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.18329658
71cellular response to interleukin-15 (GO:0071350)3.13078167
72myeloid leukocyte mediated immunity (GO:0002444)3.12648571
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.11679681
74regulation of gamma-delta T cell differentiation (GO:0045586)3.11443272
75positive regulation of interferon-alpha production (GO:0032727)3.11045519
76leukocyte degranulation (GO:0043299)3.10439619
77regulation of interferon-alpha production (GO:0032647)3.09742191
78antigen processing and presentation via MHC class Ib (GO:0002475)3.09644719
79response to protozoan (GO:0001562)3.08155916
80positive regulation of mast cell activation involved in immune response (GO:0033008)3.06606460
81positive regulation of mast cell degranulation (GO:0043306)3.06606460
82negative regulation of erythrocyte differentiation (GO:0045647)3.06200058
83positive regulation of cellular amide metabolic process (GO:0034250)3.03805974
84neutrophil chemotaxis (GO:0030593)3.01460492
85negative regulation of interleukin-6 production (GO:0032715)2.98159591
86positive regulation of type 2 immune response (GO:0002830)2.97011075
87myeloid leukocyte activation (GO:0002274)2.95617723
88neutrophil migration (GO:1990266)2.93644220
89regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.92785729
90negative regulation of innate immune response (GO:0045824)2.92470464
91regulation of antigen processing and presentation (GO:0002577)2.92058221
92T-helper 1 type immune response (GO:0042088)2.91788438
93negative regulation of type 2 immune response (GO:0002829)2.90427425
94regulation of regulated secretory pathway (GO:1903305)2.87698261
95negative regulation of T-helper cell differentiation (GO:0045623)2.87266765
96negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.87266765
97B cell receptor signaling pathway (GO:0050853)2.87025631
98positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.86874959
99negative regulation of alpha-beta T cell activation (GO:0046636)2.86752938
100dendritic cell chemotaxis (GO:0002407)2.85516136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.55360915
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.99248479
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.65294532
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.64464964
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.56727518
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.43695934
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.42381673
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06567949
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.00148826
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.97279194
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88952295
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84317774
13SPI1_23547873_ChIP-Seq_NB4_Human2.68047053
14VDR_21846776_ChIP-Seq_THP-1_Human2.67117463
15VDR_24763502_ChIP-Seq_THP-1_Human2.65041011
16SPI1_23127762_ChIP-Seq_K562_Human2.59847533
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.57396496
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.57110038
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.45703222
20RUNX_20019798_ChIP-Seq_JUKART_Human2.41956938
21* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.38534076
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.29624205
23MAF_26560356_Chip-Seq_TH1_Human2.23914560
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.19379354
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.18711125
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.17919723
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.17711576
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.15983881
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.12176441
30SCL_19346495_ChIP-Seq_HPC-7_Human2.08738552
31MYB_26560356_Chip-Seq_TH2_Human2.06591613
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.05285788
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96421278
34UTX_26944678_Chip-Seq_JUKART_Human1.95226234
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90704450
36VDR_24787735_ChIP-Seq_THP-1_Human1.89542273
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.85768809
38MYC_22102868_ChIP-Seq_BL_Human1.83397239
39TCF7_22412390_ChIP-Seq_EML_Mouse1.82226332
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78862219
41MYB_26560356_Chip-Seq_TH1_Human1.77423699
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.77031889
43* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65958097
44KDM2B_26808549_Chip-Seq_DND41_Human1.64360546
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64168405
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.63953267
47MAF_26560356_Chip-Seq_TH2_Human1.62876559
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58048230
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52886253
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.50047576
51LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49762472
52GATA3_27048872_Chip-Seq_THYMUS_Human1.49553668
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49042061
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44576464
55* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42699430
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40516962
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38520197
58* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37078798
59PU_27001747_Chip-Seq_BMDM_Mouse1.37037513
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35786266
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.35027362
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33988815
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29792614
64* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29673686
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29339856
66SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28890671
67LXR_22292898_ChIP-Seq_THP-1_Human1.27979263
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.27937809
69* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25669543
70* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25575959
71* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19891914
72GATA3_26560356_Chip-Seq_TH2_Human1.19339266
73IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17942326
74GATA1_22025678_ChIP-Seq_K562_Human1.16671448
75GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16608670
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15807501
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14345514
78GATA1_19941826_ChIP-Seq_K562_Human1.12470066
79* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09530794
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.08785340
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08735159
82KDM2B_26808549_Chip-Seq_JURKAT_Human1.08121454
83* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04635829
84* BCL6_27268052_Chip-Seq_Bcells_Human1.02651382
85NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00623435
86BCOR_27268052_Chip-Seq_Bcells_Human0.99844485
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.99793777
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99328420
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96933276
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90022402
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89837093
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.89207215
93GATA2_19941826_ChIP-Seq_K562_Human0.86029614
94NCOR1_26117541_ChIP-Seq_K562_Human0.84347603
95CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83087334
96* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81966832
97SPI1_20517297_ChIP-Seq_HL60_Human0.80047128
98GATA1_19941827_ChIP-Seq_MEL86_Mouse0.74963936
99RACK7_27058665_Chip-Seq_MCF-7_Human0.74051373
100KDM2B_26808549_Chip-Seq_K562_Human0.73132468

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.17216474
2MP0003303_peritoneal_inflammation4.45620005
3MP0003436_decreased_susceptibility_to4.30933412
4MP0001835_abnormal_antigen_presentation3.68272037
5MP0002419_abnormal_innate_immunity3.24686940
6MP0009785_altered_susceptibility_to3.12464195
7MP0006082_CNS_inflammation3.11752418
8MP0005025_abnormal_response_to2.95283342
9MP0005671_abnormal_response_to2.91362192
10MP0005000_abnormal_immune_tolerance2.87744728
11MP0005387_immune_system_phenotype2.85974689
12MP0001790_abnormal_immune_system2.85974689
13MP0001800_abnormal_humoral_immune2.74708285
14MP0002148_abnormal_hypersensitivity_rea2.65951826
15MP0000685_abnormal_immune_system2.61931160
16MP0002723_abnormal_immune_serum2.55481406
17MP0003300_gastrointestinal_ulcer2.51608191
18* MP0002452_abnormal_antigen_presenting2.46667238
19* MP0002420_abnormal_adaptive_immunity2.38940030
20* MP0001819_abnormal_immune_cell2.37252002
21MP0001533_abnormal_skeleton_physiology2.30403707
22MP0003191_abnormal_cellular_cholesterol2.27254172
23MP0002405_respiratory_system_inflammati1.98438139
24MP0003172_abnormal_lysosome_physiology1.96197590
25MP0009278_abnormal_bone_marrow1.92594279
26MP0005464_abnormal_platelet_physiology1.89289957
27MP0004510_myositis1.89099632
28MP0001845_abnormal_inflammatory_respons1.83162499
29MP0008260_abnormal_autophagy1.82574859
30MP0010155_abnormal_intestine_physiology1.80762324
31MP0009764_decreased_sensitivity_to1.78951750
32MP0004947_skin_inflammation1.75319241
33* MP0000716_abnormal_immune_system1.73115622
34MP0005451_abnormal_body_composition1.71330499
35MP0005058_abnormal_lysosome_morphology1.71276251
36MP0003828_pulmonary_edema1.68379245
37* MP0002398_abnormal_bone_marrow1.66899143
38MP0003075_altered_response_to1.64262408
39MP0003763_abnormal_thymus_physiology1.63346572
40MP0002132_abnormal_respiratory_system1.59539723
41MP0008469_abnormal_protein_level1.57238680
42MP0009333_abnormal_splenocyte_physiolog1.48288327
43MP0005310_abnormal_salivary_gland1.44093898
44MP0003183_abnormal_peptide_metabolism1.41523211
45MP0000465_gastrointestinal_hemorrhage1.41158788
46MP0000689_abnormal_spleen_morphology1.40588089
47MP0001545_abnormal_hematopoietic_system1.40331770
48MP0005397_hematopoietic_system_phenotyp1.40331770
49MP0002277_abnormal_respiratory_mucosa1.39980224
50MP0002722_abnormal_immune_system1.38937606
51MP0000858_altered_metastatic_potential1.37472065
52MP0003690_abnormal_glial_cell1.36105075
53MP0002998_abnormal_bone_remodeling1.35564616
54* MP0002429_abnormal_blood_cell1.34513812
55MP0004883_abnormal_blood_vessel1.33185509
56MP0000343_altered_response_to1.29456912
57MP0003866_abnormal_defecation1.26828854
58MP0008004_abnormal_stomach_pH1.26132118
59MP0005164_abnormal_response_to1.17902908
60MP0005166_decreased_susceptibility_to1.17834306
61MP0001851_eye_inflammation1.17346953
62MP0003448_altered_tumor_morphology1.12831620
63MP0003806_abnormal_nucleotide_metabolis1.10680530
64MP0000703_abnormal_thymus_morphology1.10498373
65MP0001853_heart_inflammation1.05800447
66MP0000604_amyloidosis1.04516652
67MP0002396_abnormal_hematopoietic_system1.03451796
68MP0004381_abnormal_hair_follicle1.00167251
69MP0005390_skeleton_phenotype0.94373238
70MP0009763_increased_sensitivity_to0.90494717
71MP0009840_abnormal_foam_cell0.89270034
72MP0001663_abnormal_digestive_system0.84763893
73MP0003656_abnormal_erythrocyte_physiolo0.80764886
74MP0002332_abnormal_exercise_endurance0.80679810
75MP0005167_abnormal_blood-brain_barrier0.74584241
76MP0009765_abnormal_xenobiotic_induced0.73674902
77MP0004808_abnormal_hematopoietic_stem0.69524491
78MP0008874_decreased_physiological_sensi0.68564476
79MP0000490_abnormal_crypts_of0.68082308
80MP0003795_abnormal_bone_structure0.67824062
81MP0003045_fibrosis0.67495312
82MP0003453_abnormal_keratinocyte_physiol0.66445774
83MP0002138_abnormal_hepatobiliary_system0.65467078
84MP0001873_stomach_inflammation0.65127788
85MP0002933_joint_inflammation0.64252089
86MP0000249_abnormal_blood_vessel0.62190381
87MP0002166_altered_tumor_susceptibility0.61469104
88MP0006054_spinal_hemorrhage0.60523692
89MP0003221_abnormal_cardiomyocyte_apopto0.60359706
90MP0001986_abnormal_taste_sensitivity0.60320806
91MP0000920_abnormal_myelination0.59153247
92MP0003091_abnormal_cell_migration0.57379092
93MP0005319_abnormal_enzyme/_coenzyme0.57232564
94MP0002254_reproductive_system_inflammat0.57189144
95MP0004858_abnormal_nervous_system0.55253637
96MP0000015_abnormal_ear_pigmentation0.51252867
97MP0005076_abnormal_cell_differentiation0.49617430
98MP0004130_abnormal_muscle_cell0.48124107
99MP0003329_amyloid_beta_deposits0.46613215
100MP0002693_abnormal_pancreas_physiology0.46529975

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.73348512
2Recurrent abscess formation (HP:0002722)6.11089326
3Recurrent bacterial skin infections (HP:0005406)6.08544370
4Myositis (HP:0100614)6.07639729
5Orchitis (HP:0100796)5.98367084
6Abnormality of macrophages (HP:0004311)5.92077683
7Optic neuritis (HP:0100653)5.68957847
8Retrobulbar optic neuritis (HP:0100654)5.68957847
9Stomatitis (HP:0010280)5.14323790
10Recurrent gram-negative bacterial infections (HP:0005420)5.14161193
11Elevated erythrocyte sedimentation rate (HP:0003565)4.52707025
12Mediastinal lymphadenopathy (HP:0100721)4.28540395
13Gastrointestinal infarctions (HP:0005244)4.09299893
14Keratoconjunctivitis sicca (HP:0001097)4.08865206
15Chronic obstructive pulmonary disease (HP:0006510)4.07660682
16Obstructive lung disease (HP:0006536)4.07660682
17Recurrent fungal infections (HP:0002841)3.97384403
18Recurrent skin infections (HP:0001581)3.85507422
19Meningitis (HP:0001287)3.78935911
20Keratoconjunctivitis (HP:0001096)3.78640027
21Encephalitis (HP:0002383)3.62402116
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.49382377
23Gingivitis (HP:0000230)3.49281165
24Spontaneous hematomas (HP:0007420)3.48676533
25Vasculitis (HP:0002633)3.48171610
26Increased IgE level (HP:0003212)3.44359823
27Urticaria (HP:0001025)3.40982841
28Abnormality of glycolipid metabolism (HP:0010969)3.25768850
29Abnormality of liposaccharide metabolism (HP:0010968)3.25768850
30Abnormality of glycosphingolipid metabolism (HP:0004343)3.25768850
31Recurrent cutaneous fungal infections (HP:0011370)3.25179475
32Chronic mucocutaneous candidiasis (HP:0002728)3.25179475
33Episodic fever (HP:0001954)3.18086578
34Hemoptysis (HP:0002105)3.14956532
35Pulmonary infiltrates (HP:0002113)3.12607366
36Amyloidosis (HP:0011034)3.04054240
37Prolonged bleeding time (HP:0003010)3.02648822
38Chest pain (HP:0100749)3.01220043
39Hypochromic microcytic anemia (HP:0004840)3.00828355
40Cellulitis (HP:0100658)2.94281740
41Anorexia (HP:0002039)2.90827426
42Arterial thrombosis (HP:0004420)2.90153581
43Peritonitis (HP:0002586)2.87640509
44Increased cerebral lipofuscin (HP:0011813)2.87556227
45T lymphocytopenia (HP:0005403)2.80330993
46Leukocytosis (HP:0001974)2.79750646
47Gingival bleeding (HP:0000225)2.74111541
48Hypochromic anemia (HP:0001931)2.74037592
49Loss of speech (HP:0002371)2.72151736
50Pulmonary embolism (HP:0002204)2.70282939
51Increased IgM level (HP:0003496)2.69107740
52Abnormality of T cell number (HP:0011839)2.67955149
53Petechiae (HP:0000967)2.67035444
54Recurrent viral infections (HP:0004429)2.62510799
55Gangrene (HP:0100758)2.61144186
56Epistaxis (HP:0000421)2.55065431
57Inflammation of the large intestine (HP:0002037)2.47464391
58Purpura (HP:0000979)2.44779501
59Abnormality of the pleura (HP:0002103)2.43687596
60Gastrointestinal inflammation (HP:0004386)2.37274081
61Increased serum ferritin (HP:0003281)2.36141642
62Osteomyelitis (HP:0002754)2.34833626
63Disinhibition (HP:0000734)2.34499325
64Pustule (HP:0200039)2.34233259
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.28375341
66Systemic lupus erythematosus (HP:0002725)2.28111846
67Hypergammaglobulinemia (HP:0010702)2.25835666
68Abnormality of T cells (HP:0002843)2.24118869
69Sepsis (HP:0100806)2.24057360
70Hepatosplenomegaly (HP:0001433)2.23170292
71Granulocytopenia (HP:0001913)2.22061595
72Abnormality of the peritoneum (HP:0002585)2.19777742
73Abnormality of the endocardium (HP:0004306)2.19104806
74Vertigo (HP:0002321)2.18553514
75Dysostosis multiplex (HP:0000943)2.18343818
76Glomerulopathy (HP:0100820)2.16609245
77Autoimmune thrombocytopenia (HP:0001973)2.16265569
78Acne (HP:0001061)2.14241641
79Abnormality of iron homeostasis (HP:0011031)2.13155342
80Premature loss of primary teeth (HP:0006323)2.12626563
81Abnormality of the pericardium (HP:0001697)2.10796182
82Polyneuropathy (HP:0001271)2.09032572
83Lymphopenia (HP:0001888)2.07708838
84Keratitis (HP:0000491)2.07693494
85Microcytic anemia (HP:0001935)2.05579525
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.03979096
87Panhypogammaglobulinemia (HP:0003139)2.03584500
88Colitis (HP:0002583)2.00403772
89Vacuolated lymphocytes (HP:0001922)1.97668582
90Abnormality of cells of the lymphoid lineage (HP:0012140)1.94555522
91Skin ulcer (HP:0200042)1.90895194
92Eosinophilia (HP:0001880)1.89346145
93Interstitial pulmonary disease (HP:0006530)1.87991572
94Slow saccadic eye movements (HP:0000514)1.85590087
95Chronic otitis media (HP:0000389)1.84086212
96Recurrent pneumonia (HP:0006532)1.83224151
97Hematochezia (HP:0002573)1.82938601
98Abnormality of T cell physiology (HP:0011840)1.82741767
99Malnutrition (HP:0004395)1.79430749
100Arthralgia (HP:0002829)1.79135269

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.84487187
2BLK3.39795944
3MAP4K13.31260306
4IRAK43.31126555
5MAP2K33.02311504
6TYK22.95478702
7ERN12.92678120
8CSK2.86391679
9FES2.29004047
10TNK22.20410096
11PRPF4B2.20409767
12TAOK12.14115649
13EPHB12.06773093
14ZAP702.06635854
15MAP3K32.06416471
16FGR2.04134928
17MAP3K141.93018348
18GRK61.87467352
19MAP3K111.86553282
20JAK31.83166306
21TXK1.81229399
22HCK1.67466208
23BTK1.64190349
24TBK11.62929859
25IKBKE1.60895963
26SYK1.55137464
27JAK21.46211648
28MATK1.40502917
29LYN1.39010984
30SIK31.38790208
31MAP3K11.34677736
32TAOK21.34524176
33MAP3K131.32230452
34JAK11.32004139
35KSR21.19986615
36YES11.13375500
37CSF1R1.12869781
38IRAK31.11549907
39LCK1.11483068
40IRAK11.10691730
41GRK71.09336353
42MARK31.05353324
43IKBKB1.05193311
44IRAK21.03720978
45TAOK31.02261583
46KIT1.00861070
47BMPR21.00442469
48TGFBR20.98171016
49MARK20.95764629
50PRKD20.90509158
51STK100.90043613
52TESK20.85560763
53PTK60.83911191
54CDC42BPA0.83282860
55PDK10.83269608
56SIK20.82479543
57ITK0.81108459
58PDPK10.76587082
59MAP3K60.75464461
60TRIB30.71978278
61MAP3K50.70956070
62TEC0.68952997
63EPHA30.66169235
64FYN0.65004670
65MOS0.58624785
66CDK190.56924118
67MAPK70.55482199
68DYRK1B0.55174817
69MAP2K40.54452685
70MAPK120.52835181
71LRRK20.52832977
72DAPK20.51960871
73MAP3K20.50198646
74MAP3K70.50043881
75SIK10.49432197
76PTK2B0.48323991
77MAP2K60.48126063
78RIPK10.47954137
79FGFR40.47641626
80STK110.47125853
81HIPK20.46232235
82RPS6KC10.46038893
83RPS6KL10.46038893
84FGFR30.45510189
85SGK30.45253022
86SMG10.43557034
87PIM10.42006122
88PRKCQ0.41123889
89KSR10.38503669
90RPS6KA60.38097839
91MAPKAPK20.36479221
92PIK3CG0.35520604
93RAF10.34719924
94PRKG20.33735097
95DYRK30.33499414
96RET0.32389554
97STK380.31800725
98CHUK0.29431350
99PRKCZ0.28937955
100PRKCD0.28463418

Predicted pathways (KEGG)

RankGene SetZ-score
1* Osteoclast differentiation_Homo sapiens_hsa043803.10553496
2Leishmaniasis_Homo sapiens_hsa051403.07919856
3Staphylococcus aureus infection_Homo sapiens_hsa051502.99425071
4Allograft rejection_Homo sapiens_hsa053302.39725613
5Graft-versus-host disease_Homo sapiens_hsa053322.35736893
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.33899078
7Tuberculosis_Homo sapiens_hsa051522.28884306
8Malaria_Homo sapiens_hsa051442.14607883
9Autoimmune thyroid disease_Homo sapiens_hsa053202.12755955
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.10673309
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.06402281
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01368998
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.94611957
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92114698
15* B cell receptor signaling pathway_Homo sapiens_hsa046621.86444558
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.79863324
17Legionellosis_Homo sapiens_hsa051341.79578716
18Type I diabetes mellitus_Homo sapiens_hsa049401.73517051
19Primary immunodeficiency_Homo sapiens_hsa053401.68484143
20Measles_Homo sapiens_hsa051621.68268485
21Chemokine signaling pathway_Homo sapiens_hsa040621.67986430
22Hematopoietic cell lineage_Homo sapiens_hsa046401.64491939
23Antigen processing and presentation_Homo sapiens_hsa046121.59723827
24Toxoplasmosis_Homo sapiens_hsa051451.59184468
25Influenza A_Homo sapiens_hsa051641.58108023
26Other glycan degradation_Homo sapiens_hsa005111.56558240
27Acute myeloid leukemia_Homo sapiens_hsa052211.54825280
28TNF signaling pathway_Homo sapiens_hsa046681.53966182
29African trypanosomiasis_Homo sapiens_hsa051431.53439463
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.53301265
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.53300924
32Phagosome_Homo sapiens_hsa041451.51918651
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.47663135
34Viral myocarditis_Homo sapiens_hsa054161.47352827
35Asthma_Homo sapiens_hsa053101.43743459
36Rheumatoid arthritis_Homo sapiens_hsa053231.43457976
37T cell receptor signaling pathway_Homo sapiens_hsa046601.38913733
38Pertussis_Homo sapiens_hsa051331.38795257
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.38243087
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.35525496
41Herpes simplex infection_Homo sapiens_hsa051681.33815027
42Salmonella infection_Homo sapiens_hsa051321.24837883
43Lysosome_Homo sapiens_hsa041421.23605274
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12737162
45Hepatitis C_Homo sapiens_hsa051601.12208676
46Hepatitis B_Homo sapiens_hsa051611.11449957
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.09922850
48Shigellosis_Homo sapiens_hsa051311.04135072
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04060553
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01766611
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97522268
52Platelet activation_Homo sapiens_hsa046110.96364260
53Apoptosis_Homo sapiens_hsa042100.90442710
54Non-small cell lung cancer_Homo sapiens_hsa052230.89899172
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.88198762
56VEGF signaling pathway_Homo sapiens_hsa043700.88085136
57Prolactin signaling pathway_Homo sapiens_hsa049170.82186855
58Pancreatic cancer_Homo sapiens_hsa052120.81763671
59Chronic myeloid leukemia_Homo sapiens_hsa052200.77640786
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76072096
61Amoebiasis_Homo sapiens_hsa051460.75876225
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.74489875
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74180518
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.72026791
65Endocytosis_Homo sapiens_hsa041440.71959912
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.70696608
67Renal cell carcinoma_Homo sapiens_hsa052110.68605590
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66849055
69Epstein-Barr virus infection_Homo sapiens_hsa051690.65918826
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64184055
71Notch signaling pathway_Homo sapiens_hsa043300.64081450
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.59580252
73FoxO signaling pathway_Homo sapiens_hsa040680.56908065
74Type II diabetes mellitus_Homo sapiens_hsa049300.56770191
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56559120
76GnRH signaling pathway_Homo sapiens_hsa049120.51452023
77Viral carcinogenesis_Homo sapiens_hsa052030.50995799
78Dorso-ventral axis formation_Homo sapiens_hsa043200.50542438
79HIF-1 signaling pathway_Homo sapiens_hsa040660.50438479
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48116635
81Collecting duct acid secretion_Homo sapiens_hsa049660.46696194
82HTLV-I infection_Homo sapiens_hsa051660.46203542
83Insulin resistance_Homo sapiens_hsa049310.44601238
84Endometrial cancer_Homo sapiens_hsa052130.44214537
85Choline metabolism in cancer_Homo sapiens_hsa052310.43334250
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42946351
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41978010
88MAPK signaling pathway_Homo sapiens_hsa040100.41611918
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40128539
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39195101
91Bladder cancer_Homo sapiens_hsa052190.38739498
92mTOR signaling pathway_Homo sapiens_hsa041500.38595642
93Rap1 signaling pathway_Homo sapiens_hsa040150.37646454
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36649482
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35537887
96Complement and coagulation cascades_Homo sapiens_hsa046100.34621289
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34082883
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33800445
99Regulation of autophagy_Homo sapiens_hsa041400.31233021
100Colorectal cancer_Homo sapiens_hsa052100.30385202

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