LILRA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1production of molecular mediator involved in inflammatory response (GO:0002532)6.90084333
2positive regulation of macrophage cytokine production (GO:0060907)6.22052365
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.98690707
4negative regulation of cell killing (GO:0031342)5.98690707
5positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.54238223
6positive regulation of gamma-delta T cell activation (GO:0046645)5.48832573
7T-helper 1 type immune response (GO:0042088)5.38108952
8positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610815.24068784
9regulation of interferon-beta biosynthetic process (GO:0045357)5.16413712
10leukocyte aggregation (GO:0070486)5.07176707
11response to peptidoglycan (GO:0032494)5.05177972
12negative regulation of interleukin-12 production (GO:0032695)5.00524193
13detection of bacterium (GO:0016045)4.99383731
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.90135288
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.87257239
16positive regulation of monocyte chemotaxis (GO:0090026)4.84467463
17leukocyte migration involved in inflammatory response (GO:0002523)4.81117881
18negative regulation of interleukin-17 production (GO:0032700)4.66001833
19G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.65498837
20low-density lipoprotein particle remodeling (GO:0034374)4.59254719
21antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.40880722
22positive regulation of cellular amide metabolic process (GO:0034250)4.39272752
23detection of external biotic stimulus (GO:0098581)4.32174845
24neutrophil activation (GO:0042119)4.24718124
25regulation of cholesterol esterification (GO:0010872)4.21190461
26regulation of macrophage cytokine production (GO:0010935)4.18561032
27positive regulation of B cell differentiation (GO:0045579)4.18538521
28regulation of B cell receptor signaling pathway (GO:0050855)4.15423836
29cellular extravasation (GO:0045123)4.08598218
30negative regulation of lymphocyte mediated immunity (GO:0002707)4.08376735
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05991665
32detection of molecule of bacterial origin (GO:0032490)4.05905214
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.05883948
34regulation of gamma-delta T cell activation (GO:0046643)4.02169249
35antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99560951
36respiratory burst (GO:0045730)3.99184101
37plasma lipoprotein particle clearance (GO:0034381)3.97578843
38granulocyte activation (GO:0036230)3.94913988
39detection of biotic stimulus (GO:0009595)3.87989939
40cellular response to type I interferon (GO:0071357)3.87014942
41type I interferon signaling pathway (GO:0060337)3.87014942
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.86662415
43response to host immune response (GO:0052572)3.85921149
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.85921149
45response to type I interferon (GO:0034340)3.85386851
46regulation of T cell tolerance induction (GO:0002664)3.83740519
47complement activation, alternative pathway (GO:0006957)3.78095870
48regulation of interleukin-12 biosynthetic process (GO:0045075)3.77386762
49negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.76874905
50phospholipid efflux (GO:0033700)3.74832410
51negative regulation of T cell mediated immunity (GO:0002710)3.74581878
52myeloid cell activation involved in immune response (GO:0002275)3.71885161
53regulation of mast cell degranulation (GO:0043304)3.69038512
54macrophage activation (GO:0042116)3.67600307
55regulation of macrophage chemotaxis (GO:0010758)3.67223688
56positive regulation of triglyceride lipase activity (GO:0061365)3.67121918
57positive regulation of lipoprotein lipase activity (GO:0051006)3.67121918
58positive regulation of mast cell activation (GO:0033005)3.66202821
59regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.64852242
60microglial cell activation (GO:0001774)3.63311650
61regulation of interleukin-8 biosynthetic process (GO:0045414)3.62854504
62neutrophil mediated immunity (GO:0002446)3.58340960
63regulation of mast cell activation (GO:0033003)3.58178186
64negative regulation of leukocyte mediated immunity (GO:0002704)3.57167057
65positive regulation of interferon-alpha production (GO:0032727)3.55620444
66high-density lipoprotein particle remodeling (GO:0034375)3.54404123
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.51931485
68regulation of monocyte chemotaxis (GO:0090025)3.51665441
69I-kappaB phosphorylation (GO:0007252)3.48707728
70detection of other organism (GO:0098543)3.48343598
71response to interleukin-15 (GO:0070672)3.45448105
72interferon-gamma-mediated signaling pathway (GO:0060333)3.44599806
73regulation of mast cell activation involved in immune response (GO:0033006)3.44487918
74antigen processing and presentation of endogenous antigen (GO:0019883)3.44307872
75defense response to protozoan (GO:0042832)3.44030469
76response to host (GO:0075136)3.41673765
77response to host defenses (GO:0052200)3.41673765
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.41673765
79pinocytosis (GO:0006907)3.39922439
80macrophage activation involved in immune response (GO:0002281)3.38997313
81regulation of mononuclear cell migration (GO:0071675)3.38527722
82regulation of dendritic cell antigen processing and presentation (GO:0002604)3.36884961
83B cell mediated immunity (GO:0019724)3.35141728
84positive regulation by symbiont of host defense response (GO:0052509)3.34234840
85modulation by symbiont of host defense response (GO:0052031)3.34234840
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.34234840
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.34234840
88positive regulation by organism of defense response of other organism involved in symbiotic interact3.34234840
89modulation by symbiont of host immune response (GO:0052553)3.34234840
90regulation of myeloid leukocyte mediated immunity (GO:0002886)3.33660742
91regulation of interferon-alpha production (GO:0032647)3.29986425
92positive regulation of smooth muscle cell migration (GO:0014911)3.27271774
93reverse cholesterol transport (GO:0043691)3.27201022
94negative regulation of cytokine production involved in immune response (GO:0002719)3.27175600
95positive regulation of mast cell degranulation (GO:0043306)3.23819216
96positive regulation of mast cell activation involved in immune response (GO:0033008)3.23819216
97macroautophagy (GO:0016236)3.21346906
98regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.21157427
99germinal center formation (GO:0002467)3.20700836
100plasma lipoprotein particle remodeling (GO:0034369)3.19853156
101protein-lipid complex remodeling (GO:0034368)3.19853156
102macromolecular complex remodeling (GO:0034367)3.19853156
103cellular response to interleukin-15 (GO:0071350)3.19742238
104regulation of interleukin-17 production (GO:0032660)3.17753505
105leukocyte degranulation (GO:0043299)3.17494579
106immunoglobulin mediated immune response (GO:0016064)3.17256419
107transcytosis (GO:0045056)3.16840951
108regulation of antigen processing and presentation (GO:0002577)3.15646823
109eosinophil chemotaxis (GO:0048245)3.15556977
110myeloid leukocyte mediated immunity (GO:0002444)3.15348418
111cellular response to ethanol (GO:0071361)3.13775532
112negative regulation of interleukin-6 production (GO:0032715)3.13519455
113regulation of T cell mediated cytotoxicity (GO:0001914)3.13058602
114negative regulation of innate immune response (GO:0045824)3.12826834
115positive regulation of antigen processing and presentation (GO:0002579)3.12016747
116response to muramyl dipeptide (GO:0032495)3.11668851
117negative regulation of sterol transport (GO:0032372)3.11589956
118negative regulation of cholesterol transport (GO:0032375)3.11589956
119positive regulation of cholesterol efflux (GO:0010875)3.11346116
120response to protozoan (GO:0001562)3.10815282
121regulation of gamma-delta T cell differentiation (GO:0045586)3.10682196
122interferon-gamma production (GO:0032609)3.09999939
123neutrophil activation involved in immune response (GO:0002283)3.09827505
124regulation of leukocyte degranulation (GO:0043300)3.09501925
125negative regulation of interleukin-1 production (GO:0032692)3.07659027
126antigen processing and presentation via MHC class Ib (GO:0002475)3.07114223
127regulation of T-helper 2 cell differentiation (GO:0045628)3.06734618
128negative regulation of alpha-beta T cell activation (GO:0046636)3.05503275
129regulation of neutrophil chemotaxis (GO:0090022)3.03586999
130regulation of neutrophil migration (GO:1902622)3.03586999
131cholesterol efflux (GO:0033344)3.01987081
132regulation of platelet activation (GO:0010543)3.01474511
133regulation of cholesterol storage (GO:0010885)3.01365730
134purinergic nucleotide receptor signaling pathway (GO:0035590)3.01146498
135negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.00625344
136negative regulation of T-helper cell differentiation (GO:0045623)3.00625344
137L-phenylalanine catabolic process (GO:0006559)3.00425141
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.00425141
139negative regulation of type 2 immune response (GO:0002829)2.99843575
140regulation of B cell differentiation (GO:0045577)2.99428397
141positive regulation of neutrophil chemotaxis (GO:0090023)2.99350021
142positive regulation of neutrophil migration (GO:1902624)2.99350021
143positive regulation of interleukin-1 beta secretion (GO:0050718)2.97758675
144lipopolysaccharide-mediated signaling pathway (GO:0031663)2.97478074
145regulation of MHC class II biosynthetic process (GO:0045346)2.96756817
146neutrophil chemotaxis (GO:0030593)2.96320020
147positive regulation of type 2 immune response (GO:0002830)2.96281624
148protein carboxylation (GO:0018214)2.95628451
149peptidyl-glutamic acid carboxylation (GO:0017187)2.95628451
150positive regulation of T cell mediated cytotoxicity (GO:0001916)2.95465666
151G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.95154327
152positive regulation of hemostasis (GO:1900048)2.94991577
153positive regulation of blood coagulation (GO:0030194)2.94991577
154positive regulation of cholesterol transport (GO:0032376)2.91888813
155positive regulation of sterol transport (GO:0032373)2.91888813
156alpha-linolenic acid metabolic process (GO:0036109)2.91766677
157regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91758812
158negative regulation of interleukin-1 beta production (GO:0032691)2.90947071
159myeloid leukocyte activation (GO:0002274)2.90514884
160lipoxygenase pathway (GO:0019372)2.89679602
161neutrophil migration (GO:1990266)2.88752298
162complement activation (GO:0006956)2.87351796
163positive regulation of coagulation (GO:0050820)2.84374178
164aromatic amino acid family catabolic process (GO:0009074)2.84162182
165import into cell (GO:0098657)2.84009202
166negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.83645003
167regulation of protein activation cascade (GO:2000257)2.81002176
168intestinal epithelial cell development (GO:0060576)2.79316870
169regulation of triglyceride catabolic process (GO:0010896)2.79147625
170plasma lipoprotein particle assembly (GO:0034377)2.77690009
171regulation of cholesterol metabolic process (GO:0090181)2.77426944
172positive regulation of granulocyte chemotaxis (GO:0071624)2.77153163
173bile acid biosynthetic process (GO:0006699)2.76745447
174regulation of tolerance induction (GO:0002643)2.75578956
175indolalkylamine catabolic process (GO:0046218)2.74533560

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.00517524
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.79809298
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.67633283
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.23743708
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.81225338
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58499198
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.53894034
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.18487576
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.16473490
10EGR1_23403033_ChIP-Seq_LIVER_Mouse3.14194832
11LXR_22158963_ChIP-Seq_LIVER_Mouse3.04059980
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.91159806
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72855574
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.43433419
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36944312
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.28609721
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.26616346
18VDR_21846776_ChIP-Seq_THP-1_Human2.21838510
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15911447
20MYB_26560356_Chip-Seq_TH2_Human2.14952708
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.14070182
22E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.11435653
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06734400
24STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03493344
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91521238
26MYB_21317192_ChIP-Seq_ERMYB_Mouse1.89908991
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.88558333
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.82284395
29UTX_26944678_Chip-Seq_JUKART_Human1.80905329
30CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80267526
31EGR1_19032775_ChIP-ChIP_M12_Human1.78351040
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77713244
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.76647278
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.73733369
35GATA3_27048872_Chip-Seq_THYMUS_Human1.72515383
36RUNX_20019798_ChIP-Seq_JUKART_Human1.69349443
37GATA1_22025678_ChIP-Seq_K562_Human1.66212967
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65278656
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.64974459
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62457896
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60556347
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60216008
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56292636
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50537942
45MAF_26560356_Chip-Seq_TH2_Human1.48653579
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.46740433
47VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.46643446
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45937663
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44256733
50CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42369751
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41221560
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40586036
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.31748976
54SPI1_23127762_ChIP-Seq_K562_Human1.31593371
55ESR2_21235772_ChIP-Seq_MCF-7_Human1.31331864
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28223872
57VDR_24787735_ChIP-Seq_THP-1_Human1.27204544
58SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24102324
59TCF7_22412390_ChIP-Seq_EML_Mouse1.23867751
60BCAT_22108803_ChIP-Seq_LS180_Human1.23700458
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23612685
62PU_27001747_Chip-Seq_BMDM_Mouse1.21240627
63* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21029678
64KDM2B_26808549_Chip-Seq_DND41_Human1.20640695
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19323007
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18798010
67VDR_24763502_ChIP-Seq_THP-1_Human1.18661083
68BCL6_27268052_Chip-Seq_Bcells_Human1.17597637
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17540868
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17540868
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17122953
72CDX2_20551321_ChIP-Seq_CACO-2_Human1.14953786
73MYC_22102868_ChIP-Seq_BL_Human1.14947042
74ESR1_21235772_ChIP-Seq_MCF-7_Human1.14183099
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13890694
76GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12635341
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12503074
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11861976
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.10763969
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10025337
81CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07034434
82TP53_18474530_ChIP-ChIP_U2OS_Human1.04750782
83SCL_19346495_ChIP-Seq_HPC-7_Human1.04664225
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04604597
85GATA2_19941826_ChIP-Seq_K562_Human1.04085228
86* SPI1_23547873_ChIP-Seq_NB4_Human1.02930581
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.02806494
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02398113
89BCOR_27268052_Chip-Seq_Bcells_Human1.02163215
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01876601
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01697520
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00652708
93SOX2_20726797_ChIP-Seq_SW620_Human0.99979564
94GATA1_19941826_ChIP-Seq_K562_Human0.98711600
95RUNX1_22412390_ChIP-Seq_EML_Mouse0.97924861
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96828869
97CLOCK_20551151_ChIP-Seq_293T_Human0.94876043
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.94709655
99NOTCH1_21737748_ChIP-Seq_TLL_Human0.94703892
100FOXA2_19822575_ChIP-Seq_HepG2_Human0.92998367
101PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92913288
102SMRT_27268052_Chip-Seq_Bcells_Human0.92785001
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91871423
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90123834
105STAT1_20625510_ChIP-Seq_HELA_Human0.89423201
106MAF_26560356_Chip-Seq_TH1_Human0.89282282
107RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88906115
108SPI1_20517297_ChIP-Seq_HL60_Human0.87921830
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87432794
110RXR_22108803_ChIP-Seq_LS180_Human0.86896400
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.86198246
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85613356
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84403511
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.83961241
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.83311820
116SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81316631
117P300_27268052_Chip-Seq_Bcells_Human0.80665194
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79991707
119PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79689191
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79528160
121STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79251071
122CJUN_26792858_Chip-Seq_BT549_Human0.78591738
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77994406
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.77508741
125TRIM28_21343339_ChIP-Seq_HEK293_Human0.76496502
126SMAD_19615063_ChIP-ChIP_OVARY_Human0.74583181
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.74227749
128CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74016152
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.73007179
130PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72902253
131RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72868107
132ELF1_17652178_ChIP-ChIP_JURKAT_Human0.72766426
133MYB_26560356_Chip-Seq_TH1_Human0.72524898
134KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72306815
135KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72306815
136KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72306815
137GATA3_26560356_Chip-Seq_TH2_Human0.71249916
138KDM2B_26808549_Chip-Seq_JURKAT_Human0.71221985
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.70677921
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.69748079
141GATA3_26560356_Chip-Seq_TH1_Human0.69638267
142GATA1_19941827_ChIP-Seq_MEL_Mouse0.69403169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.08649690
2MP0009840_abnormal_foam_cell4.63880253
3MP0003191_abnormal_cellular_cholesterol4.10933938
4MP0003724_increased_susceptibility_to3.14619354
5MP0002139_abnormal_hepatobiliary_system2.99817595
6MP0005085_abnormal_gallbladder_physiolo2.99715387
7MP0006082_CNS_inflammation2.91931572
8MP0003690_abnormal_glial_cell2.86413148
9MP0005058_abnormal_lysosome_morphology2.75904227
10MP0003075_altered_response_to2.72414563
11MP0005360_urolithiasis2.56025928
12MP0002148_abnormal_hypersensitivity_rea2.48962418
13MP0002419_abnormal_innate_immunity2.37426880
14MP0003252_abnormal_bile_duct2.24918632
15MP0009764_decreased_sensitivity_to2.18645938
16MP0002132_abnormal_respiratory_system2.16181751
17MP0000604_amyloidosis2.05002859
18MP0003436_decreased_susceptibility_to2.02437077
19MP0001790_abnormal_immune_system1.99186820
20MP0005387_immune_system_phenotype1.99186820
21MP0005000_abnormal_immune_tolerance1.98737545
22MP0005025_abnormal_response_to1.97419301
23MP0003172_abnormal_lysosome_physiology1.94234433
24MP0000465_gastrointestinal_hemorrhage1.93039295
25MP0000685_abnormal_immune_system1.90913662
26MP0003045_fibrosis1.89338754
27MP0004510_myositis1.88369660
28MP0008875_abnormal_xenobiotic_pharmacok1.82648362
29MP0004130_abnormal_muscle_cell1.80166297
30MP0004883_abnormal_blood_vessel1.73105841
31MP0010329_abnormal_lipoprotein_level1.69961867
32MP0002398_abnormal_bone_marrow1.69699789
33MP0005365_abnormal_bile_salt1.66064175
34MP0005166_decreased_susceptibility_to1.63916893
35MP0009785_altered_susceptibility_to1.63823900
36MP0003183_abnormal_peptide_metabolism1.63199909
37MP0001853_heart_inflammation1.62621747
38MP0003763_abnormal_thymus_physiology1.57050444
39MP0005464_abnormal_platelet_physiology1.55573031
40MP0003828_pulmonary_edema1.54707819
41MP0002452_abnormal_antigen_presenting1.54443274
42MP0002405_respiratory_system_inflammati1.54393593
43MP0000343_altered_response_to1.51707537
44MP0001533_abnormal_skeleton_physiology1.51302627
45MP0001800_abnormal_humoral_immune1.47535988
46MP0002138_abnormal_hepatobiliary_system1.42512599
47MP0002723_abnormal_immune_serum1.42318091
48MP0005310_abnormal_salivary_gland1.41470637
49MP0003329_amyloid_beta_deposits1.41030846
50MP0002722_abnormal_immune_system1.39188537
51MP0002429_abnormal_blood_cell1.35341817
52MP0008469_abnormal_protein_level1.34695063
53MP0010368_abnormal_lymphatic_system1.29858624
54MP0005164_abnormal_response_to1.28053649
55MP0003866_abnormal_defecation1.27829048
56MP0005174_abnormal_tail_pigmentation1.27423101
57MP0009333_abnormal_splenocyte_physiolog1.27406222
58MP0005671_abnormal_response_to1.26835669
59MP0005397_hematopoietic_system_phenotyp1.26105335
60MP0001545_abnormal_hematopoietic_system1.26105335
61MP0000609_abnormal_liver_physiology1.24667131
62MP0004019_abnormal_vitamin_homeostasis1.19774307
63MP0001845_abnormal_inflammatory_respons1.16575595
64MP0008260_abnormal_autophagy1.15977031
65MP0003300_gastrointestinal_ulcer1.15077785
66MP0002420_abnormal_adaptive_immunity1.14493684
67MP0001819_abnormal_immune_cell1.14469868
68MP0008004_abnormal_stomach_pH1.12298276
69MP0004782_abnormal_surfactant_physiolog1.12026457
70MP0005334_abnormal_fat_pad1.11909405
71MP0004147_increased_porphyrin_level1.11298372
72MP0002998_abnormal_bone_remodeling1.10634294
73MP0002118_abnormal_lipid_homeostasis1.10423908
74MP0003303_peritoneal_inflammation1.07943868
75MP0005409_darkened_coat_color1.06480696
76MP0000015_abnormal_ear_pigmentation1.05028931
77MP0000703_abnormal_thymus_morphology1.05017943
78MP0002090_abnormal_vision1.02872926
79MP0002653_abnormal_ependyma_morphology1.01572381
80MP0003279_aneurysm1.00506364
81MP0001986_abnormal_taste_sensitivity1.00019598
82MP0001663_abnormal_digestive_system0.99453989
83MP0003448_altered_tumor_morphology0.99351402
84MP0005584_abnormal_enzyme/coenzyme_acti0.96432425
85MP0001851_eye_inflammation0.96149969
86MP0009763_increased_sensitivity_to0.95497747
87MP0003705_abnormal_hypodermis_morpholog0.95184583
88MP0005319_abnormal_enzyme/_coenzyme0.94531342
89MP0002168_other_aberrant_phenotype0.94161887
90MP0005076_abnormal_cell_differentiation0.92563027
91MP0001873_stomach_inflammation0.90901498
92MP0009115_abnormal_fat_cell0.90540805
93MP0005390_skeleton_phenotype0.90402514
94MP0004381_abnormal_hair_follicle0.89508325
95MP0000920_abnormal_myelination0.87600035
96MP0009765_abnormal_xenobiotic_induced0.86892115
97MP0001666_abnormal_nutrient_absorption0.86778438
98MP0005167_abnormal_blood-brain_barrier0.85821113
99MP0002295_abnormal_pulmonary_circulatio0.85470565
100MP0009278_abnormal_bone_marrow0.84399831
101MP0002396_abnormal_hematopoietic_system0.84076142
102MP0002332_abnormal_exercise_endurance0.82822011
103MP0005332_abnormal_amino_acid0.82599333
104MP0000716_abnormal_immune_system0.81330136
105MP0004947_skin_inflammation0.80767308
106MP0001727_abnormal_embryo_implantation0.79746987
107MP0003638_abnormal_response/metabolism_0.79357293
108MP0005451_abnormal_body_composition0.79200611
109MP0005083_abnormal_biliary_tract0.77668447
110MP0002971_abnormal_brown_adipose0.75367558
111MP0003806_abnormal_nucleotide_metabolis0.74565077
112MP0000733_abnormal_muscle_development0.74361789
113MP0000858_altered_metastatic_potential0.74118794
114MP0002277_abnormal_respiratory_mucosa0.72653561
115MP0000689_abnormal_spleen_morphology0.72569953
116MP0005084_abnormal_gallbladder_morpholo0.71877972
117MP0003656_abnormal_erythrocyte_physiolo0.71671072
118MP0000371_diluted_coat_color0.71185640
119MP0008438_abnormal_cutaneous_collagen0.69713393
120MP0002933_joint_inflammation0.69638333
121MP0005646_abnormal_pituitary_gland0.69150983
122MP0003632_abnormal_nervous_system0.68456241
123MP0000249_abnormal_blood_vessel0.67775054
124MP0010155_abnormal_intestine_physiology0.67648075
125MP0003646_muscle_fatigue0.64762336
126MP0000490_abnormal_crypts_of0.62719678
127MP0005075_abnormal_melanosome_morpholog0.62699559
128MP0002693_abnormal_pancreas_physiology0.61522343
129MP0008874_decreased_physiological_sensi0.59172390
130MP0002928_abnormal_bile_duct0.56825223
131MP0003795_abnormal_bone_structure0.55090589
132MP0002254_reproductive_system_inflammat0.54872685
133MP0003878_abnormal_ear_physiology0.53227557
134MP0005377_hearing/vestibular/ear_phenot0.53227557
135MP0001501_abnormal_sleep_pattern0.53112950
136MP0002166_altered_tumor_susceptibility0.52741451
137MP0003195_calcinosis0.52697505
138MP0005381_digestive/alimentary_phenotyp0.50841544

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.44706373
2Complement deficiency (HP:0004431)6.76597321
3Glomerulonephritis (HP:0000099)6.70829952
4Eczematoid dermatitis (HP:0000976)6.08665819
5Stomatitis (HP:0010280)5.86896830
6Abnormality of complement system (HP:0005339)5.51058419
7Myocardial infarction (HP:0001658)4.98229494
8Elevated erythrocyte sedimentation rate (HP:0003565)4.96452097
9Recurrent abscess formation (HP:0002722)4.70026793
10Recurrent bacterial skin infections (HP:0005406)4.25415662
11Gastrointestinal infarctions (HP:0005244)4.22332281
12Recurrent gram-negative bacterial infections (HP:0005420)4.21759070
13Xanthomatosis (HP:0000991)4.01779145
14Orchitis (HP:0100796)3.96456790
15Retrobulbar optic neuritis (HP:0100654)3.96258701
16Optic neuritis (HP:0100653)3.96258701
17Obstructive lung disease (HP:0006536)3.94047972
18Chronic obstructive pulmonary disease (HP:0006510)3.94047972
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.90020777
20Joint hemorrhage (HP:0005261)3.83641960
21Vacuolated lymphocytes (HP:0001922)3.73098213
22Nephritis (HP:0000123)3.72541658
23Cerebral palsy (HP:0100021)3.62456890
24Neurofibrillary tangles (HP:0002185)3.60857052
25Vasculitis (HP:0002633)3.58505619
26Deep venous thrombosis (HP:0002625)3.46737138
27Arterial thrombosis (HP:0004420)3.45425516
28Urticaria (HP:0001025)3.40809266
29Hemoptysis (HP:0002105)3.36446532
30Osteolytic defects of the hand bones (HP:0009699)3.29749467
31Osteolytic defects of the phalanges of the hand (HP:0009771)3.29749467
32Episodic fever (HP:0001954)3.27489286
33Polycythemia (HP:0001901)3.24094706
34Prolonged partial thromboplastin time (HP:0003645)3.24025322
35Myositis (HP:0100614)3.20900508
36Leukocytosis (HP:0001974)3.16638601
37Hypochromic microcytic anemia (HP:0004840)3.16289230
38Esophageal varix (HP:0002040)3.07129225
39Hypochromic anemia (HP:0001931)3.05106636
40Increased IgE level (HP:0003212)3.02008371
41Spontaneous hematomas (HP:0007420)3.00814386
42Abnormality of liposaccharide metabolism (HP:0010968)3.00363591
43Abnormality of glycosphingolipid metabolism (HP:0004343)3.00363591
44Abnormality of glycolipid metabolism (HP:0010969)3.00363591
45Abnormality of lateral ventricle (HP:0030047)2.98956437
46Recurrent skin infections (HP:0001581)2.98550942
47Cerebral hemorrhage (HP:0001342)2.97396841
48Prolonged bleeding time (HP:0003010)2.92334755
49Increased IgM level (HP:0003496)2.89348252
50T lymphocytopenia (HP:0005403)2.89244117
51Dysostosis multiplex (HP:0000943)2.88235610
52Abnormality of T cell number (HP:0011839)2.88008525
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.84279987
54Abnormal glucose tolerance (HP:0001952)2.78356888
55Cerebral inclusion bodies (HP:0100314)2.76696983
56Abnormality of the pleura (HP:0002103)2.73025157
57Intrahepatic cholestasis (HP:0001406)2.72017958
58Thrombophlebitis (HP:0004418)2.69347452
59Testicular atrophy (HP:0000029)2.65674858
60Mediastinal lymphadenopathy (HP:0100721)2.65077551
61Colitis (HP:0002583)2.64552796
62Hypercholesterolemia (HP:0003124)2.63078748
63Peritonitis (HP:0002586)2.61419214
64Keratoconjunctivitis sicca (HP:0001097)2.60448884
65Recurrent viral infections (HP:0004429)2.60405857
66Abnormality of macrophages (HP:0004311)2.58284953
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.56606567
68Petechiae (HP:0000967)2.56460473
69Abnormal platelet function (HP:0011869)2.54314481
70Impaired platelet aggregation (HP:0003540)2.54314481
71Thick nail (HP:0001805)2.51118839
72Abnormality of the vasculature of the conjunctiva (HP:0008054)2.50287945
73Fetal akinesia sequence (HP:0001989)2.49975337
74Abnormality of T cells (HP:0002843)2.48583386
75Cellulitis (HP:0100658)2.48253101
76Axonal loss (HP:0003447)2.47910631
77Periodontitis (HP:0000704)2.46960999
78Fatigue (HP:0012378)2.45069756
79Pustule (HP:0200039)2.44997368
80Disproportionate tall stature (HP:0001519)2.44173797
81Autoimmune thrombocytopenia (HP:0001973)2.42882570
82Conjunctival telangiectasia (HP:0000524)2.42566661
83Mesangial abnormality (HP:0001966)2.40980883
84Granulocytopenia (HP:0001913)2.40520773
85Chronic otitis media (HP:0000389)2.36531791
86Hepatocellular carcinoma (HP:0001402)2.35269084
87Pulmonary embolism (HP:0002204)2.34624479
88Keratoconjunctivitis (HP:0001096)2.32302060
89Increased serum ferritin (HP:0003281)2.30288602
90Keratitis (HP:0000491)2.29814053
91Eosinophilia (HP:0001880)2.28527800
92Osteomyelitis (HP:0002754)2.28303134
93Epistaxis (HP:0000421)2.28180131
94Increased neuronal autofluorescent lipopigment (HP:0002074)2.26926191
95Increased cerebral lipofuscin (HP:0011813)2.26528074
96Vertigo (HP:0002321)2.26423529
97Sepsis (HP:0100806)2.23204904
98Polyneuropathy (HP:0001271)2.22609893
99Recurrent cutaneous fungal infections (HP:0011370)2.20116439
100Chronic mucocutaneous candidiasis (HP:0002728)2.20116439
101Loss of speech (HP:0002371)2.19431956
102Adactyly (HP:0009776)2.18815899
103Abnormality of the pericardium (HP:0001697)2.18523987
104Abnormality of iron homeostasis (HP:0011031)2.18311120
105Encephalitis (HP:0002383)2.17725518
106Hypergammaglobulinemia (HP:0010702)2.17148285
107Pulmonary infiltrates (HP:0002113)2.16162424
108Mucopolysacchariduria (HP:0008155)2.15612326
109Urinary glycosaminoglycan excretion (HP:0003541)2.15612326
110Thrombocytosis (HP:0001894)2.15568100
111Abnormality of the endocardium (HP:0004306)2.14389886
112Acne (HP:0001061)2.13556357
113Abnormality of glutamine family amino acid metabolism (HP:0010902)2.12878791
114Abnormality of T cell physiology (HP:0011840)2.12172223
115Disinhibition (HP:0000734)2.11707571
116Anorexia (HP:0002039)2.10629474
117Hematochezia (HP:0002573)2.10103156
118Amaurosis fugax (HP:0100576)2.09084292
119Hyperlipoproteinemia (HP:0010980)2.07862597
120Arterial tortuosity (HP:0005116)2.07486980
121Lymphopenia (HP:0001888)2.06944743
122Gingivitis (HP:0000230)2.06763208
123Purpura (HP:0000979)2.06100187
124Abnormality of the common coagulation pathway (HP:0010990)2.05920396
125Inflammation of the large intestine (HP:0002037)2.04932505
126Gastrointestinal inflammation (HP:0004386)2.04699391
127Arthropathy (HP:0003040)2.04205527
128Agnosia (HP:0010524)2.03812895
129Hepatosplenomegaly (HP:0001433)2.03054152
130Microcytic anemia (HP:0001935)2.02872122
131Abnormality of eosinophils (HP:0001879)2.01888079
132Amyloidosis (HP:0011034)1.99508189
133Glomerulopathy (HP:0100820)1.99307938
134Stomach cancer (HP:0012126)1.97349252
135Epidermoid cyst (HP:0200040)1.97271160
136Late onset (HP:0003584)1.95562746
137Abnormality of transition element cation homeostasis (HP:0011030)1.95232791
138Recurrent fungal infections (HP:0002841)1.95203750
139Hypoalphalipoproteinemia (HP:0003233)1.95200215
140Abnormality of polysaccharide metabolism (HP:0011012)1.94575929
141Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94575929
142Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94575929
143Recurrent pneumonia (HP:0006532)1.93989250
144Abnormality of cells of the lymphoid lineage (HP:0012140)1.93479610
145Abnormality of secondary sexual hair (HP:0009888)1.91895877
146Abnormality of the axillary hair (HP:0100134)1.91895877
147Hemorrhage of the eye (HP:0011885)1.91259661
148Hypobetalipoproteinemia (HP:0003563)1.87872159
149Prostate neoplasm (HP:0100787)1.87726069
150Abnormality of the peritoneum (HP:0002585)1.84397163
151Premature loss of primary teeth (HP:0006323)1.84354234
152Meningitis (HP:0001287)1.83730698
153Cheilitis (HP:0100825)1.83014545
154Chest pain (HP:0100749)1.82614735
155Gingival bleeding (HP:0000225)1.82347035
156Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82060421
157Gangrene (HP:0100758)1.81487566
158Panhypogammaglobulinemia (HP:0003139)1.79684292
159Hyperammonemia (HP:0001987)1.79474881
160Recurrent bronchitis (HP:0002837)1.79176426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR26.76817937
2GRK74.47061957
3SIK23.21391803
4STK103.01185465
5BLK2.95487875
6ZAP702.89298378
7MOS2.71040497
8RIPK42.49662750
9IRAK42.42379847
10TNK22.32575327
11GRK62.21025759
12YES12.15155874
13NEK92.11431844
14GRK52.11367188
15MAP3K142.09217015
16MAP4K12.08740309
17TAOK12.06229698
18EPHB12.05137793
19BTK1.98704565
20MAP3K111.90051997
21MAP3K31.83498515
22CDK91.78937957
23MAPKAPK51.73922988
24TYK21.68841413
25ERN11.63869680
26HCK1.59444334
27BMPR21.46573842
28TAOK31.33582110
29CDK61.33526560
30ADRBK21.33352142
31EIF2AK21.30307097
32TEC1.24880579
33CSK1.24678264
34SYK1.23627795
35ITK1.20750474
36JAK21.20024385
37LCK1.19567264
38PRPF4B1.19369975
39IKBKB1.17357691
40IRAK11.16341734
41MARK31.12775234
42MAP3K101.10713981
43JAK11.09826418
44TBK11.09507952
45SIK31.07584659
46MAP3K11.07365325
47MAP3K131.03562506
48TAOK20.99107372
49PKN10.95817187
50LYN0.95717522
51KIT0.91442426
52TXK0.91142723
53ABL10.90773179
54CSF1R0.88381733
55JAK30.88246182
56CAMK1D0.86960702
57IRAK20.86566870
58PRKD20.86352449
59FES0.84132862
60FGFR40.83821126
61MAPK110.80835883
62TTN0.79247833
63MAPK120.74731089
64EGFR0.74531489
65MARK20.73917124
66MAPK150.73456329
67IGF1R0.71907591
68IKBKE0.69665756
69CHUK0.68806552
70MAP2K40.68780535
71KSR20.68588233
72MAP2K60.68479071
73ACVR1B0.68321160
74PTK60.68299141
75CAMKK20.67959510
76MAP3K60.65450033
77IRAK30.64954888
78PTK2B0.64695197
79STK110.64287944
80PDK10.64259226
81MAPKAPK20.62780018
82MAP3K50.62478306
83PDPK10.61600016
84PRKCD0.61538326
85PRKCQ0.61536769
86FRK0.59743931
87TESK20.59009960
88MAP2K20.57953144
89CDC42BPA0.57900229
90ADRBK10.55299085
91PIK3CG0.53513836
92INSR0.53474958
93HIPK20.53414021
94PRKD10.53374900
95CDK190.52108536
96RPS6KA60.51230739
97FYN0.50338391
98ABL20.50322704
99PINK10.49386860
100PDGFRB0.47872020
101TLK10.46512351
102DYRK30.46395432
103MAPK70.45879560
104MAPK40.45586446
105RPS6KC10.44943323
106RPS6KL10.44943323
107DYRK1B0.44403417
108GSK3A0.44267693
109MAP3K70.42709777
110KDR0.41286325
111CLK10.40909996
112DAPK20.39479952
113TRPM70.38296049
114GRK10.37912388
115PAK40.36676079
116SCYL20.35700035
117PRKCZ0.35347084
118SRC0.34782099
119STK40.33457561
120MAP3K120.33099386
121MINK10.32734924
122NLK0.32379446
123SGK30.32342434
124EPHA30.32212100
125NEK20.31089692
126PIM10.31048251
127MAP2K30.30635452
128CAMKK10.29056936
129PRKACB0.29028364
130PRKACG0.28276552
131PRKAA20.27208400
132SIK10.26509372
133PBK0.25461539
134OXSR10.25204912
135MAP3K20.24716811
136MATK0.24466339
137LRRK20.23128294
138FGR0.20602345
139MST1R0.20032297
140PAK60.18948098
141FGFR30.18413864

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.26176994
2Complement and coagulation cascades_Homo sapiens_hsa046103.66270523
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.10662844
4Nitrogen metabolism_Homo sapiens_hsa009102.86866236
5Leishmaniasis_Homo sapiens_hsa051402.44798200
6Caffeine metabolism_Homo sapiens_hsa002322.38821255
7Pertussis_Homo sapiens_hsa051332.25970226
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10327951
9Asthma_Homo sapiens_hsa053101.97438072
10Arginine biosynthesis_Homo sapiens_hsa002201.96851168
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.85591053
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84629632
13Legionellosis_Homo sapiens_hsa051341.83964049
14Prion diseases_Homo sapiens_hsa050201.83676515
15Malaria_Homo sapiens_hsa051441.80816754
16Tuberculosis_Homo sapiens_hsa051521.76842366
17Lysosome_Homo sapiens_hsa041421.76012299
18Fatty acid degradation_Homo sapiens_hsa000711.70627513
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69019837
20Other glycan degradation_Homo sapiens_hsa005111.63024017
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.53238225
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51554412
23Tryptophan metabolism_Homo sapiens_hsa003801.50572451
24Fatty acid metabolism_Homo sapiens_hsa012121.48213397
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46345391
26TNF signaling pathway_Homo sapiens_hsa046681.46142643
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.43984858
28Phagosome_Homo sapiens_hsa041451.43889424
29PPAR signaling pathway_Homo sapiens_hsa033201.42256520
30Viral myocarditis_Homo sapiens_hsa054161.42181723
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.39049647
32Rheumatoid arthritis_Homo sapiens_hsa053231.36329733
33Herpes simplex infection_Homo sapiens_hsa051681.34010501
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33141709
35Retinol metabolism_Homo sapiens_hsa008301.29676775
36B cell receptor signaling pathway_Homo sapiens_hsa046621.28434756
37Salmonella infection_Homo sapiens_hsa051321.26766798
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26153072
39* Osteoclast differentiation_Homo sapiens_hsa043801.26133454
40Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24954368
41Peroxisome_Homo sapiens_hsa041461.20902414
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.19644212
43Acute myeloid leukemia_Homo sapiens_hsa052211.18851414
44African trypanosomiasis_Homo sapiens_hsa051431.12970751
45Butanoate metabolism_Homo sapiens_hsa006501.12576290
46Chemical carcinogenesis_Homo sapiens_hsa052041.09960317
47Histidine metabolism_Homo sapiens_hsa003401.09080119
48Antigen processing and presentation_Homo sapiens_hsa046121.05975127
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05584649
50Allograft rejection_Homo sapiens_hsa053301.04968821
51Toxoplasmosis_Homo sapiens_hsa051451.02974432
52Bile secretion_Homo sapiens_hsa049761.00903129
53Hepatitis C_Homo sapiens_hsa051600.99273561
54Graft-versus-host disease_Homo sapiens_hsa053320.98386571
55Fatty acid elongation_Homo sapiens_hsa000620.98095542
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.98087820
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.94558084
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93815586
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90309366
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89621512
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88108002
62beta-Alanine metabolism_Homo sapiens_hsa004100.87484373
63Platelet activation_Homo sapiens_hsa046110.87282594
64Steroid hormone biosynthesis_Homo sapiens_hsa001400.87010142
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84003664
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82412874
67Measles_Homo sapiens_hsa051620.81383011
68ABC transporters_Homo sapiens_hsa020100.81252479
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81038800
70Shigellosis_Homo sapiens_hsa051310.80706070
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79006675
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77800426
73Starch and sucrose metabolism_Homo sapiens_hsa005000.74317990
74Influenza A_Homo sapiens_hsa051640.72505708
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70858775
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.68687526
77Chemokine signaling pathway_Homo sapiens_hsa040620.68686916
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68530826
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67401442
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67353929
81Collecting duct acid secretion_Homo sapiens_hsa049660.64345072
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63592730
83Dorso-ventral axis formation_Homo sapiens_hsa043200.62457080
84Amoebiasis_Homo sapiens_hsa051460.61998098
85Prolactin signaling pathway_Homo sapiens_hsa049170.61861134
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60468138
87VEGF signaling pathway_Homo sapiens_hsa043700.60264206
88Type II diabetes mellitus_Homo sapiens_hsa049300.59019583
89Fat digestion and absorption_Homo sapiens_hsa049750.58415349
90Phenylalanine metabolism_Homo sapiens_hsa003600.57764134
91Epstein-Barr virus infection_Homo sapiens_hsa051690.57496728
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57436840
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57427453
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.57413191
95Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.56311800
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.53800130
97Non-small cell lung cancer_Homo sapiens_hsa052230.53460331
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53037745
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52831719
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49010214
101Regulation of autophagy_Homo sapiens_hsa041400.48634229
102FoxO signaling pathway_Homo sapiens_hsa040680.47150062
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.43464411
104Type I diabetes mellitus_Homo sapiens_hsa049400.43363329
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43032171
106Apoptosis_Homo sapiens_hsa042100.42863229
107Ether lipid metabolism_Homo sapiens_hsa005650.41737943
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.40991936
109Steroid biosynthesis_Homo sapiens_hsa001000.40942495
110Autoimmune thyroid disease_Homo sapiens_hsa053200.40594660
111Primary immunodeficiency_Homo sapiens_hsa053400.40582425
112Propanoate metabolism_Homo sapiens_hsa006400.40509651
113MAPK signaling pathway_Homo sapiens_hsa040100.40417522
114AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39589640
115Viral carcinogenesis_Homo sapiens_hsa052030.39527583
116Pancreatic cancer_Homo sapiens_hsa052120.39399678
117Hematopoietic cell lineage_Homo sapiens_hsa046400.37973008
118Arachidonic acid metabolism_Homo sapiens_hsa005900.37060744
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36000469
120Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35639064
121Renin secretion_Homo sapiens_hsa049240.35237084
122T cell receptor signaling pathway_Homo sapiens_hsa046600.34522907
123Vitamin digestion and absorption_Homo sapiens_hsa049770.34146605
124Renal cell carcinoma_Homo sapiens_hsa052110.33719165
125HTLV-I infection_Homo sapiens_hsa051660.33619370
126Tyrosine metabolism_Homo sapiens_hsa003500.33557321
127Leukocyte transendothelial migration_Homo sapiens_hsa046700.32898532
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32451899
129Notch signaling pathway_Homo sapiens_hsa043300.31558477
130Endocytosis_Homo sapiens_hsa041440.31468245
131Hepatitis B_Homo sapiens_hsa051610.31318608
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31257880
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.30936595
134Chronic myeloid leukemia_Homo sapiens_hsa052200.30205676
135Fatty acid biosynthesis_Homo sapiens_hsa000610.30159444
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29811099
137Insulin resistance_Homo sapiens_hsa049310.29240879
138GnRH signaling pathway_Homo sapiens_hsa049120.29202019
139HIF-1 signaling pathway_Homo sapiens_hsa040660.29074074
140Systemic lupus erythematosus_Homo sapiens_hsa053220.26189827
141Rap1 signaling pathway_Homo sapiens_hsa040150.25694766
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25282239
143Pentose phosphate pathway_Homo sapiens_hsa000300.24812806
144Renin-angiotensin system_Homo sapiens_hsa046140.24021939
145Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23328860
146Choline metabolism in cancer_Homo sapiens_hsa052310.22086124
147Jak-STAT signaling pathway_Homo sapiens_hsa046300.21648801
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.21373476
149Arginine and proline metabolism_Homo sapiens_hsa003300.20961775
150Morphine addiction_Homo sapiens_hsa050320.16640832

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