LIFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.68300821
2L-phenylalanine catabolic process (GO:0006559)6.68300821
3L-phenylalanine metabolic process (GO:0006558)6.34636817
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.34636817
5aromatic amino acid family catabolic process (GO:0009074)5.94458566
6indole-containing compound catabolic process (GO:0042436)5.29468072
7indolalkylamine catabolic process (GO:0046218)5.29468072
8tryptophan catabolic process (GO:0006569)5.29468072
9bile acid biosynthetic process (GO:0006699)5.21870016
10kynurenine metabolic process (GO:0070189)5.20608436
11regulation of protein activation cascade (GO:2000257)5.12116489
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.11557097
13tryptophan metabolic process (GO:0006568)4.99740140
14complement activation, alternative pathway (GO:0006957)4.98642480
15peptidyl-glutamic acid carboxylation (GO:0017187)4.95932212
16protein carboxylation (GO:0018214)4.95932212
17alpha-linolenic acid metabolic process (GO:0036109)4.94234875
18regulation of complement activation (GO:0030449)4.87376511
19sulfur amino acid catabolic process (GO:0000098)4.84822473
20glyoxylate metabolic process (GO:0046487)4.81525975
21high-density lipoprotein particle remodeling (GO:0034375)4.81042149
22urea metabolic process (GO:0019627)4.74744047
23urea cycle (GO:0000050)4.74744047
24negative regulation of fibrinolysis (GO:0051918)4.67128577
25regulation of fibrinolysis (GO:0051917)4.58554946
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.46778785
27cysteine metabolic process (GO:0006534)4.40536222
28bile acid metabolic process (GO:0008206)4.40375397
29coenzyme catabolic process (GO:0009109)4.36639384
30homocysteine metabolic process (GO:0050667)4.33349344
31reverse cholesterol transport (GO:0043691)4.32964982
32nitrogen cycle metabolic process (GO:0071941)4.32611349
33retina vasculature morphogenesis in camera-type eye (GO:0061299)4.23602579
34aromatic amino acid family metabolic process (GO:0009072)4.22710309
35tyrosine metabolic process (GO:0006570)4.18523526
36lysine catabolic process (GO:0006554)4.14963724
37lysine metabolic process (GO:0006553)4.14963724
38serine family amino acid catabolic process (GO:0009071)4.11150745
39protein-lipid complex remodeling (GO:0034368)4.08781365
40macromolecular complex remodeling (GO:0034367)4.08781365
41plasma lipoprotein particle remodeling (GO:0034369)4.08781365
42negative regulation of protein activation cascade (GO:2000258)4.04732745
43alpha-amino acid catabolic process (GO:1901606)3.99078123
44regulation of cholesterol esterification (GO:0010872)3.98095675
45amino-acid betaine metabolic process (GO:0006577)3.89059934
46phospholipid efflux (GO:0033700)3.88164284
47regulation of triglyceride catabolic process (GO:0010896)3.85478579
48acylglycerol homeostasis (GO:0055090)3.84380143
49triglyceride homeostasis (GO:0070328)3.84380143
50cellular modified amino acid catabolic process (GO:0042219)3.82434256
51dicarboxylic acid biosynthetic process (GO:0043650)3.81967898
52bile acid and bile salt transport (GO:0015721)3.81310181
53cellular amino acid catabolic process (GO:0009063)3.72233509
54cholesterol efflux (GO:0033344)3.71204722
55plasma lipoprotein particle clearance (GO:0034381)3.67408090
56indolalkylamine metabolic process (GO:0006586)3.67316126
57fibrinolysis (GO:0042730)3.67295883
58cellular ketone body metabolic process (GO:0046950)3.66562426
59cellular biogenic amine catabolic process (GO:0042402)3.63189001
60amine catabolic process (GO:0009310)3.63189001
61glutamate metabolic process (GO:0006536)3.60427188
62low-density lipoprotein particle remodeling (GO:0034374)3.59651981
63benzene-containing compound metabolic process (GO:0042537)3.53742691
64cellular glucuronidation (GO:0052695)3.49867311
65negative regulation of sterol transport (GO:0032372)3.49438112
66negative regulation of cholesterol transport (GO:0032375)3.49438112
67phospholipid homeostasis (GO:0055091)3.49100501
68acetyl-CoA metabolic process (GO:0006084)3.47886729
69positive regulation of fatty acid beta-oxidation (GO:0032000)3.46016458
70cofactor catabolic process (GO:0051187)3.42924552
71negative regulation of complement activation (GO:0045916)3.42173089
72paraxial mesoderm development (GO:0048339)3.38978361
73vascular endothelial growth factor signaling pathway (GO:0038084)3.38773555
74regulation of cholesterol biosynthetic process (GO:0045540)3.38720876
75complement activation, classical pathway (GO:0006958)3.38526291
76positive regulation of lipid catabolic process (GO:0050996)3.38315025
77imidazole-containing compound metabolic process (GO:0052803)3.36521161
78complement activation (GO:0006956)3.36007786
79morphogenesis of an epithelial sheet (GO:0002011)3.33108988
80arginine metabolic process (GO:0006525)3.32289846
81carboxylic acid catabolic process (GO:0046395)3.29195414
82organic acid catabolic process (GO:0016054)3.29195414
83plasma lipoprotein particle assembly (GO:0034377)3.28681053
84embryonic retina morphogenesis in camera-type eye (GO:0060059)3.27143172
85protein activation cascade (GO:0072376)3.25671018
86drug catabolic process (GO:0042737)3.25234483
87ethanol oxidation (GO:0006069)3.24335775
88midgut development (GO:0007494)3.24235876
89short-chain fatty acid metabolic process (GO:0046459)3.23951570
90presynaptic membrane assembly (GO:0097105)3.23913707
91intestinal cholesterol absorption (GO:0030299)3.23713532
92regulation of cholesterol metabolic process (GO:0090181)3.21655894
93regulation of cholesterol homeostasis (GO:2000188)3.21570698
94fatty acid beta-oxidation (GO:0006635)3.20013453
95cytolysis (GO:0019835)3.18499371
96regulation of bile acid biosynthetic process (GO:0070857)3.17786753
97opsonization (GO:0008228)3.16155799
98ketone body metabolic process (GO:1902224)3.14168846
99fatty acid oxidation (GO:0019395)3.13514233
100monocarboxylic acid catabolic process (GO:0072329)3.13375056
101cholesterol homeostasis (GO:0042632)3.12875558
102aspartate family amino acid catabolic process (GO:0009068)3.11981953
103uronic acid metabolic process (GO:0006063)3.11800311
104glucuronate metabolic process (GO:0019585)3.11800311
105glycine metabolic process (GO:0006544)3.11380752
106regulation of relaxation of muscle (GO:1901077)3.11373919
107lipid oxidation (GO:0034440)3.10089304
108plasma lipoprotein particle organization (GO:0071827)3.10035824
109notochord development (GO:0030903)3.08676924
110regulation of cell communication by electrical coupling (GO:0010649)3.04304631
111embryonic foregut morphogenesis (GO:0048617)3.04263804
112Notch signaling involved in heart development (GO:0061314)3.02976931
113regulation of transforming growth factor beta2 production (GO:0032909)3.01461515
114lymphangiogenesis (GO:0001946)2.90647483
115heart valve formation (GO:0003188)2.90111119
116presynaptic membrane organization (GO:0097090)2.89982340
117regulation of cardioblast differentiation (GO:0051890)2.89012585
118negative regulation of vascular permeability (GO:0043116)2.88693836
119endocardial cushion morphogenesis (GO:0003203)2.85363263
120apical protein localization (GO:0045176)2.83704694
121cell surface receptor signaling pathway involved in heart development (GO:0061311)2.82530719
122regulation of axon extension involved in axon guidance (GO:0048841)2.80228291
123cGMP-mediated signaling (GO:0019934)2.79969782
124dorsal/ventral axis specification (GO:0009950)2.73849359
125positive regulation of vascular permeability (GO:0043117)2.71072799
126endothelium development (GO:0003158)2.69213463
127cell communication by electrical coupling (GO:0010644)2.68973400
128cell migration involved in sprouting angiogenesis (GO:0002042)2.67316319
129surfactant homeostasis (GO:0043129)2.65569443
130establishment of nucleus localization (GO:0040023)2.65108610
131cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.64771646
132regulation of cardiac muscle cell contraction (GO:0086004)2.64123438
133mesenchyme morphogenesis (GO:0072132)2.63343035
134cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.63180239
135cytoskeletal anchoring at plasma membrane (GO:0007016)2.58879851
136lymph vessel development (GO:0001945)2.58470087
137negative regulation of hormone biosynthetic process (GO:0032353)2.55148870
138regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.52987249
139membrane assembly (GO:0071709)2.51921483
140astrocyte development (GO:0014002)2.51905017
141cardiac myofibril assembly (GO:0055003)2.50528595
142chemical homeostasis within a tissue (GO:0048875)2.48572891
143regulation of axon guidance (GO:1902667)2.48140924
144hippo signaling (GO:0035329)2.45804621
145coronary vasculature morphogenesis (GO:0060977)2.45020856
146peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.44351113
147postsynaptic membrane organization (GO:0001941)2.42366953
148cardiac epithelial to mesenchymal transition (GO:0060317)2.42065538
149asymmetric protein localization (GO:0008105)2.41915952
150peripheral nervous system axon ensheathment (GO:0032292)2.41818277
151myelination in peripheral nervous system (GO:0022011)2.41818277
152positive regulation of p38MAPK cascade (GO:1900745)2.41633177
153polarized epithelial cell differentiation (GO:0030859)2.41583116
154regulation of vasculogenesis (GO:2001212)2.39211004
155regulation of actin filament-based movement (GO:1903115)2.35962864
156establishment of apical/basal cell polarity (GO:0035089)2.35537487
157neuromuscular junction development (GO:0007528)2.35197421
158pericardium development (GO:0060039)2.35017147
159endothelial cell differentiation (GO:0045446)2.33230540
160regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.32561583
161positive regulation of vasculogenesis (GO:2001214)2.28782611
162regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.28276202
163atrial cardiac muscle cell action potential (GO:0086014)2.27502683
164neuron recognition (GO:0008038)2.26991818
165regulation of vascular permeability (GO:0043114)2.26361210
166positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.26267760
167branching involved in salivary gland morphogenesis (GO:0060445)2.26130859
168establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25827831
169cell migration involved in gastrulation (GO:0042074)2.24596334
170epithelial tube branching involved in lung morphogenesis (GO:0060441)2.23502481
171central nervous system myelination (GO:0022010)2.22800008
172axon ensheathment in central nervous system (GO:0032291)2.22800008
173SMAD protein signal transduction (GO:0060395)2.22620739
174axonal fasciculation (GO:0007413)2.22137939
175cellular sodium ion homeostasis (GO:0006883)2.21134930
176ectodermal placode formation (GO:0060788)2.19800780
177regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.18089827
178vasculogenesis (GO:0001570)2.17436935
179nucleus localization (GO:0051647)2.16106309
180negative regulation of hormone metabolic process (GO:0032351)2.16040071
181gastrulation with mouth forming second (GO:0001702)2.15673329
182artery development (GO:0060840)2.15040738
183lateral sprouting from an epithelium (GO:0060601)2.13488542
184negative regulation of chondrocyte differentiation (GO:0032331)2.12422675
185blood vessel morphogenesis (GO:0048514)2.11997267
186anterior/posterior axis specification, embryo (GO:0008595)2.11941750
187cellular response to cholesterol (GO:0071397)2.11757314
188heart morphogenesis (GO:0003007)2.11516395
189positive regulation of astrocyte differentiation (GO:0048711)2.11296884
190establishment of monopolar cell polarity (GO:0061162)2.11169331
191establishment or maintenance of monopolar cell polarity (GO:0061339)2.11169331
192cardiac muscle hypertrophy (GO:0003300)2.11070254
193glomerular visceral epithelial cell development (GO:0072015)2.10010447
194otic vesicle formation (GO:0030916)2.08911238
195positive regulation of cardiac muscle hypertrophy (GO:0010613)2.08497693
196positive regulation of muscle hypertrophy (GO:0014742)2.08497693
197layer formation in cerebral cortex (GO:0021819)2.07763999
198regulation of p38MAPK cascade (GO:1900744)2.07482264
199response to BMP (GO:0071772)2.06792011
200cellular response to BMP stimulus (GO:0071773)2.06792011

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.37542534
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.01256970
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.94943667
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.88539216
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.63206246
6* FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.85666052
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.63432043
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.57333978
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.11993280
10EZH2_22144423_ChIP-Seq_EOC_Human2.47629481
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.17592667
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15142130
13SALL1_21062744_ChIP-ChIP_HESCs_Human1.90338167
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.72278169
15CLOCK_20551151_ChIP-Seq_293T_Human1.70783089
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70740513
17RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69559513
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.66675175
19YAP1_20516196_ChIP-Seq_MESCs_Mouse1.62163904
20* FOXA2_19822575_ChIP-Seq_HepG2_Human1.61863337
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59413021
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58109149
23ISL1_27105846_Chip-Seq_CPCs_Mouse1.56731755
24TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.56356621
25* SMAD3_21741376_ChIP-Seq_EPCs_Human1.54528105
26WT1_19549856_ChIP-ChIP_CCG9911_Human1.52188000
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.51777891
28CTNNB1_20460455_ChIP-Seq_HCT116_Human1.51698721
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.48999160
30FUS_26573619_Chip-Seq_HEK293_Human1.47575302
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.46602544
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44597550
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.44135038
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.43451318
35GBX2_23144817_ChIP-Seq_PC3_Human1.43348176
36* SMAD3_21741376_ChIP-Seq_HESCs_Human1.42645838
37TAF15_26573619_Chip-Seq_HEK293_Human1.42632333
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42196329
39* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41162524
40* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41162524
41TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40165935
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.39302278
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39096518
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.38212105
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37658906
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36904751
47* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.36412921
48* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35741119
49ESR1_20079471_ChIP-ChIP_T-47D_Human1.35673647
50* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35480921
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33304962
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27284047
53TCF4_18268006_ChIP-ChIP_LS174T_Human1.26682505
54GATA1_22025678_ChIP-Seq_K562_Human1.25757568
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24189595
56* PIAS1_25552417_ChIP-Seq_VCAP_Human1.24167174
57BCAT_22108803_ChIP-Seq_LS180_Human1.23689106
58* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23091525
59WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22188425
60HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21998047
61* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21983622
62TP53_16413492_ChIP-PET_HCT116_Human1.20721469
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20206319
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.19935354
65AHR_22903824_ChIP-Seq_MCF-7_Human1.18669493
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17922971
67* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17865283
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.17810902
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.17573167
70* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16502274
71* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16434014
72SOX9_26525672_Chip-Seq_HEART_Mouse1.16273238
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16154092
74WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.15901077
75* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15219135
76ESR1_21235772_ChIP-Seq_MCF-7_Human1.14002308
77* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13847232
78HTT_18923047_ChIP-ChIP_STHdh_Human1.13679612
79* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11830478
80TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09895896
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.09515132
82* RNF2_27304074_Chip-Seq_NSC_Mouse1.09221066
83CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08124300
84* HNF4A_19822575_ChIP-Seq_HepG2_Human1.08076041
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.07836410
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07404303
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.06593254
88CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03788127
89ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03610927
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03342671
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.03267116
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.02643526
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02545645
94SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01978366
95EED_16625203_ChIP-ChIP_MESCs_Mouse1.00810682
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00546663
97CJUN_26792858_Chip-Seq_BT549_Human0.97126273
98* EP300_21415370_ChIP-Seq_HL-1_Mouse0.96850931
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95967225
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95412092
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94878292
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94402552
103NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92362554
104* SMAD4_21799915_ChIP-Seq_A2780_Human0.90975910
105P300_19829295_ChIP-Seq_ESCs_Human0.87939572
106AR_21572438_ChIP-Seq_LNCaP_Human0.84642655
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84320193
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84202935
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84121801
110ERG_21242973_ChIP-ChIP_JURKAT_Human0.83935488
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83081333
112AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83003566
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81822841
114* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81649901
115TP63_23658742_ChIP-Seq_EP156T_Human0.81420603
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.80843051
117RNF2_18974828_ChIP-Seq_MESCs_Mouse0.80603442
118EZH2_18974828_ChIP-Seq_MESCs_Mouse0.80603442
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.80380038
120SOX2_27498859_Chip-Seq_STOMACH_Mouse0.79188852
121* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78285327
122MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78265221
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.77761966
124SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.77741541
125SOX2_20726797_ChIP-Seq_SW620_Human0.77493767
126* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77429828
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.76177974
128SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.75437182
129ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75193977
130* TP53_18474530_ChIP-ChIP_U2OS_Human0.74971454
131* SMAD4_21741376_ChIP-Seq_HESCs_Human0.73885715
132GATA4_25053715_ChIP-Seq_YYC3_Human0.73366349
133FOXO3_23340844_ChIP-Seq_DLD1_Human0.72871258
134Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72812765
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.72362174
136* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71586814
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.70698872
138ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.70458310
139FOXM1_26456572_ChIP-Seq_MCF-7_Human0.70435146
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.70408809
141CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.70317198
142* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69292713
143* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.69292387
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.68589608
145STAT3_23295773_ChIP-Seq_U87_Human0.68034914
146TOP2B_26459242_ChIP-Seq_MCF-7_Human0.67826054
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.67753289
148* TCF4_22108803_ChIP-Seq_LS180_Human0.67210454
149FOXA1_25552417_ChIP-Seq_VCAP_Human0.66714680
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.66709289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.20909229
2MP0005360_urolithiasis6.33229003
3MP0005085_abnormal_gallbladder_physiolo5.79162507
4MP0005365_abnormal_bile_salt5.49463206
5MP0008875_abnormal_xenobiotic_pharmacok4.06913095
6MP0003806_abnormal_nucleotide_metabolis3.92761486
7MP0003252_abnormal_bile_duct3.67702494
8MP0005083_abnormal_biliary_tract3.48759042
9MP0010329_abnormal_lipoprotein_level3.06328696
10MP0003195_calcinosis2.82380727
11MP0005332_abnormal_amino_acid2.59279969
12MP0001666_abnormal_nutrient_absorption2.50685932
13MP0003941_abnormal_skin_development2.41439671
14MP0001879_abnormal_lymphatic_vessel2.37868226
15MP0000537_abnormal_urethra_morphology2.34413898
16MP0009840_abnormal_foam_cell2.15295758
17MP0002118_abnormal_lipid_homeostasis1.95559582
18MP0000778_abnormal_nervous_system1.91566319
19MP0003890_abnormal_embryonic-extraembry1.88253223
20MP0003868_abnormal_feces_composition1.86832089
21MP0003136_yellow_coat_color1.85529369
22MP0003385_abnormal_body_wall1.84161898
23MP0002138_abnormal_hepatobiliary_system1.83629553
24MP0009697_abnormal_copulation1.83531279
25MP0005623_abnormal_meninges_morphology1.81226010
26MP0004272_abnormal_basement_membrane1.79595011
27MP0004019_abnormal_vitamin_homeostasis1.77133505
28MP0000609_abnormal_liver_physiology1.74810067
29MP0002837_dystrophic_cardiac_calcinosis1.74768449
30MP0004859_abnormal_synaptic_plasticity1.73557172
31MP0003191_abnormal_cellular_cholesterol1.66161221
32MP0005187_abnormal_penis_morphology1.61369893
33MP0001958_emphysema1.58794056
34MP0000534_abnormal_ureter_morphology1.57914196
35MP0003937_abnormal_limbs/digits/tail_de1.55252304
36MP0003705_abnormal_hypodermis_morpholog1.54873360
37MP0006138_congestive_heart_failure1.53924163
38MP0002697_abnormal_eye_size1.53161335
39MP0000751_myopathy1.51603836
40MP0002876_abnormal_thyroid_physiology1.48957312
41MP0010030_abnormal_orbit_morphology1.48892291
42MP0005319_abnormal_enzyme/_coenzyme1.48264622
43MP0005423_abnormal_somatic_nervous1.47836148
44MP0004084_abnormal_cardiac_muscle1.44643947
45MP0002735_abnormal_chemical_nociception1.43000316
46MP0002254_reproductive_system_inflammat1.42677999
47MP0010368_abnormal_lymphatic_system1.40059949
48MP0000013_abnormal_adipose_tissue1.36164319
49MP0003935_abnormal_craniofacial_develop1.32546885
50MP0000462_abnormal_digestive_system1.29734036
51MP0004215_abnormal_myocardial_fiber1.27738885
52MP0003950_abnormal_plasma_membrane1.26632886
53MP0003119_abnormal_digestive_system1.26365826
54MP0005584_abnormal_enzyme/coenzyme_acti1.26124374
55MP0000428_abnormal_craniofacial_morphol1.25583522
56MP0005171_absent_coat_pigmentation1.24667006
57MP0002638_abnormal_pupillary_reflex1.18597205
58MP0009250_abnormal_appendicular_skeleto1.16319296
59MP0001764_abnormal_homeostasis1.15312443
60MP0002233_abnormal_nose_morphology1.15288489
61MP0006054_spinal_hemorrhage1.14405265
62MP0002009_preneoplasia1.12336194
63MP0002084_abnormal_developmental_patter1.11136496
64MP0001486_abnormal_startle_reflex1.10870288
65MP0000604_amyloidosis1.10320986
66MP0009643_abnormal_urine_homeostasis1.09951364
67MP0004858_abnormal_nervous_system1.05971163
68MP0000733_abnormal_muscle_development1.05855163
69MP0000762_abnormal_tongue_morphology1.05153152
70MP0005409_darkened_coat_color1.04700900
71MP0010352_gastrointestinal_tract_polyps1.02253139
72MP0003115_abnormal_respiratory_system1.00977555
73MP0001984_abnormal_olfaction0.99870443
74MP0005595_abnormal_vascular_smooth0.99029064
75MP0002127_abnormal_cardiovascular_syste0.98760254
76MP0003011_delayed_dark_adaptation0.98636701
77MP0003091_abnormal_cell_migration0.98197723
78MP0001661_extended_life_span0.98049509
79MP0002925_abnormal_cardiovascular_devel0.97898416
80MP0005084_abnormal_gallbladder_morpholo0.97723459
81MP0010630_abnormal_cardiac_muscle0.97339478
82MP0004036_abnormal_muscle_relaxation0.96881465
83MP0001915_intracranial_hemorrhage0.95493499
84MP0008438_abnormal_cutaneous_collagen0.93757967
85MP0004130_abnormal_muscle_cell0.93405979
86* MP0003634_abnormal_glial_cell0.93156808
87MP0004087_abnormal_muscle_fiber0.93067517
88* MP0000955_abnormal_spinal_cord0.93063048
89MP0000003_abnormal_adipose_tissue0.91892689
90MP0000598_abnormal_liver_morphology0.91771173
91MP0005647_abnormal_sex_gland0.91139329
92MP0009384_cardiac_valve_regurgitation0.90986483
93MP0002928_abnormal_bile_duct0.90776215
94MP0002088_abnormal_embryonic_growth/wei0.90329441
95MP0002184_abnormal_innervation0.89735420
96MP0003984_embryonic_growth_retardation0.89033059
97MP0009053_abnormal_anal_canal0.88455954
98MP0003880_abnormal_central_pattern0.88326005
99MP0003656_abnormal_erythrocyte_physiolo0.88071427
100MP0003755_abnormal_palate_morphology0.87924277
101MP0002734_abnormal_mechanical_nocicepti0.87874288
102MP0000427_abnormal_hair_cycle0.87253379
103MP0002932_abnormal_joint_morphology0.86863033
104MP0001756_abnormal_urination0.86684859
105MP0003635_abnormal_synaptic_transmissio0.86465390
106MP0009780_abnormal_chondrocyte_physiolo0.85987678
107MP0004885_abnormal_endolymph0.85854206
108MP0000049_abnormal_middle_ear0.85403387
109MP0005620_abnormal_muscle_contractility0.85332636
110MP0003861_abnormal_nervous_system0.85291022
111MP0004085_abnormal_heartbeat0.85070074
112MP0002092_abnormal_eye_morphology0.84613785
113MP0002128_abnormal_blood_circulation0.84593983
114MP0000767_abnormal_smooth_muscle0.84524298
115MP0005220_abnormal_exocrine_pancreas0.84332317
116MP0000747_muscle_weakness0.84302691
117MP0004145_abnormal_muscle_electrophysio0.83559652
118MP0005167_abnormal_blood-brain_barrier0.83097405
119MP0009703_decreased_birth_body0.82938915
120* MP0002078_abnormal_glucose_homeostasis0.82531101
121MP0001286_abnormal_eye_development0.81755261
122MP0003566_abnormal_cell_adhesion0.81713928
123MP0005670_abnormal_white_adipose0.81138156
124MP0000432_abnormal_head_morphology0.80257228
125MP0002168_other_aberrant_phenotype0.80187698
126MP0002249_abnormal_larynx_morphology0.79821690
127MP0001672_abnormal_embryogenesis/_devel0.79533172
128MP0005380_embryogenesis_phenotype0.79533172
129MP0002152_abnormal_brain_morphology0.79159404
130MP0003329_amyloid_beta_deposits0.78693044
131MP0005367_renal/urinary_system_phenotyp0.78136592
132MP0000516_abnormal_urinary_system0.78136592
133MP0002133_abnormal_respiratory_system0.77510318
134MP0005388_respiratory_system_phenotype0.77510318
135MP0000749_muscle_degeneration0.76855483
136MP0004484_altered_response_of0.76731387
137MP0000579_abnormal_nail_morphology0.76351663
138MP0002736_abnormal_nociception_after0.75874875
139MP0005535_abnormal_body_temperature0.74526009
140MP0009764_decreased_sensitivity_to0.74507257
141MP0001968_abnormal_touch/_nociception0.70015435
142MP0005379_endocrine/exocrine_gland_phen0.69678837
143MP0006276_abnormal_autonomic_nervous0.68291772
144MP0005503_abnormal_tendon_morphology0.67771318
145MP0005451_abnormal_body_composition0.66037512
146MP0009642_abnormal_blood_homeostasis0.65786696
147MP0005376_homeostasis/metabolism_phenot0.64665807
148MP0005408_hypopigmentation0.64600930
149MP0003690_abnormal_glial_cell0.64402710
150MP0009763_increased_sensitivity_to0.64224473
151MP0005636_abnormal_mineral_homeostasis0.64220453
152MP0000639_abnormal_adrenal_gland0.63420013
153MP0001346_abnormal_lacrimal_gland0.63199195
154MP0002896_abnormal_bone_mineralization0.62715983
155MP0002295_abnormal_pulmonary_circulatio0.59336436
156MP0004883_abnormal_blood_vessel0.58930726
157MP0005334_abnormal_fat_pad0.57196603
158MP0004270_analgesia0.56350222
159MP0003186_abnormal_redox_activity0.56039972
160MP0009379_abnormal_foot_pigmentation0.55892188
161MP0005448_abnormal_energy_balance0.55857025
162MP0003045_fibrosis0.55112022
163MP0003279_aneurysm0.53372291
164MP0005275_abnormal_skin_tensile0.52906039
165MP0000538_abnormal_urinary_bladder0.51788962
166MP0001177_atelectasis0.50928394
167MP0002971_abnormal_brown_adipose0.50921841
168MP0000230_abnormal_systemic_arterial0.48266246
169MP0002060_abnormal_skin_morphology0.47580410
170MP0002108_abnormal_muscle_morphology0.47373343
171MP0005666_abnormal_adipose_tissue0.46965275
172MP0005395_other_phenotype0.46363110
173MP0008469_abnormal_protein_level0.46317450
174MP0009765_abnormal_xenobiotic_induced0.45256593
175MP0005248_abnormal_Harderian_gland0.43743566
176MP0001299_abnormal_eye_distance/0.43409828
177MP0003724_increased_susceptibility_to0.42919167
178MP0003942_abnormal_urinary_system0.42433133
179MP0002796_impaired_skin_barrier0.41568236
180MP0001986_abnormal_taste_sensitivity0.40733633
181MP0001348_abnormal_lacrimal_gland0.40138752
182MP0002269_muscular_atrophy0.39438258

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.79201836
2Deep venous thrombosis (HP:0002625)6.56350756
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.35024001
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.74610875
5Prolonged partial thromboplastin time (HP:0003645)5.74486310
6Xanthomatosis (HP:0000991)5.56691117
7Complement deficiency (HP:0004431)5.31836837
8Hypobetalipoproteinemia (HP:0003563)4.83575226
9Hyperlipoproteinemia (HP:0010980)4.43610445
10Epidermoid cyst (HP:0200040)4.05646707
11Abnormality of the common coagulation pathway (HP:0010990)4.05542462
12Hyperammonemia (HP:0001987)4.04517373
13Joint hemorrhage (HP:0005261)4.01688877
14Hypolipoproteinemia (HP:0010981)4.00813663
15Abnormality of methionine metabolism (HP:0010901)3.96318058
16Hypoalphalipoproteinemia (HP:0003233)3.91141856
17Hypoglycemic coma (HP:0001325)3.86791053
18Ketosis (HP:0001946)3.86635040
19Abnormality of sulfur amino acid metabolism (HP:0004339)3.85475561
20Abnormality of complement system (HP:0005339)3.82855672
21Abnormality of aspartate family amino acid metabolism (HP:0010899)3.82704895
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.71974825
23Hyperglycinemia (HP:0002154)3.71869310
24Fat malabsorption (HP:0002630)3.68965872
25Abnormality of the intrinsic pathway (HP:0010989)3.67604859
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.59572247
27Hyperglycinuria (HP:0003108)3.41410946
28Conjugated hyperbilirubinemia (HP:0002908)3.41038739
29Abnormality of glycine metabolism (HP:0010895)3.33363119
30Abnormality of serine family amino acid metabolism (HP:0010894)3.33363119
31Ketoacidosis (HP:0001993)3.00522505
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.96475802
33Skin nodule (HP:0200036)2.92696408
34Arterial tortuosity (HP:0005116)2.91871741
35Spontaneous abortion (HP:0005268)2.87532868
36Cutaneous syndactyly (HP:0012725)2.86828656
37Vascular tortuosity (HP:0004948)2.86032118
38Abnormality of fatty-acid metabolism (HP:0004359)2.85902981
39Hypercholesterolemia (HP:0003124)2.81275120
40Myocardial infarction (HP:0001658)2.78486786
41Hyperbilirubinemia (HP:0002904)2.77662009
42Delayed CNS myelination (HP:0002188)2.76195037
43Aplasia involving bones of the upper limbs (HP:0009823)2.71676900
44Aplasia of the phalanges of the hand (HP:0009802)2.71676900
45Aplasia involving bones of the extremities (HP:0009825)2.71676900
46Systemic lupus erythematosus (HP:0002725)2.70192665
47Absent eyelashes (HP:0000561)2.68056259
48Steatorrhea (HP:0002570)2.66637690
49Abnormality of pyrimidine metabolism (HP:0004353)2.65307699
50Hypoglycemic seizures (HP:0002173)2.61637340
51Abnormality of serum amino acid levels (HP:0003112)2.56677663
52Hepatocellular carcinoma (HP:0001402)2.55308118
53Abnormality of nucleobase metabolism (HP:0010932)2.52732090
54Hypoplasia of the iris (HP:0007676)2.51754329
55Hypophosphatemic rickets (HP:0004912)2.49842716
56Gout (HP:0001997)2.48155353
57Abnormality of purine metabolism (HP:0004352)2.46444285
58Wide anterior fontanel (HP:0000260)2.45838449
59Hypochromic microcytic anemia (HP:0004840)2.45798825
60Glomerulonephritis (HP:0000099)2.41549849
61Mitral stenosis (HP:0001718)2.36877400
62Neonatal short-limb short stature (HP:0008921)2.34896892
63Absent eyebrow (HP:0002223)2.27155167
64Vertebral arch anomaly (HP:0008438)2.23486964
65Aortic dissection (HP:0002647)2.23091810
66Hyperinsulinemic hypoglycemia (HP:0000825)2.22797968
67Limited hip movement (HP:0008800)2.22408844
68Metabolic acidosis (HP:0001942)2.21250884
69Coronal craniosynostosis (HP:0004440)2.20529598
70Midline defect of the nose (HP:0004122)2.20371783
71Shallow orbits (HP:0000586)2.19877225
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19613707
73Short 4th metacarpal (HP:0010044)2.19613707
74Neonatal onset (HP:0003623)2.19102136
75Vascular calcification (HP:0004934)2.18801960
76Premature rupture of membranes (HP:0001788)2.17989504
77Action tremor (HP:0002345)2.13031086
78Enlarged kidneys (HP:0000105)2.12067122
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.11494518
80Dicarboxylic aciduria (HP:0003215)2.11494518
81Abnormal gallbladder morphology (HP:0012437)2.10172686
82Hyperglycemia (HP:0003074)2.09950066
83Rickets (HP:0002748)2.09092178
84Bell-shaped thorax (HP:0001591)2.09075002
85Cardiovascular calcification (HP:0011915)2.07595002
86Myelomeningocele (HP:0002475)2.07191464
87Papillary thyroid carcinoma (HP:0002895)2.07176618
88Morphological abnormality of the middle ear (HP:0008609)2.06843678
89Lethargy (HP:0001254)2.06072347
90Irritability (HP:0000737)2.05479883
91Esophageal varix (HP:0002040)2.01542909
92Preaxial foot polydactyly (HP:0001841)2.01056289
93Sensorimotor neuropathy (HP:0007141)1.99398823
94Abnormality of proline metabolism (HP:0010907)1.98454438
95Hydroxyprolinuria (HP:0003080)1.98454438
96Overgrowth (HP:0001548)1.97266913
97Aortic aneurysm (HP:0004942)1.97249040
98Proximal tubulopathy (HP:0000114)1.97203103
99Ulnar bowing (HP:0003031)1.96977716
100Hepatoblastoma (HP:0002884)1.96674839
101Cerebral aneurysm (HP:0004944)1.96193026
102Amyloidosis (HP:0011034)1.94767753
103Acanthocytosis (HP:0001927)1.93730515
104Protrusio acetabuli (HP:0003179)1.92069452
105Cholelithiasis (HP:0001081)1.91912802
106Bilateral microphthalmos (HP:0007633)1.88660099
107Pancreatitis (HP:0001733)1.87717239
108Abnormality of the 4th metacarpal (HP:0010012)1.85747966
109Missing ribs (HP:0000921)1.85458721
110Turricephaly (HP:0000262)1.84378265
111Pulmonic stenosis (HP:0001642)1.84132489
112Difficulty running (HP:0009046)1.83074684
113Soft skin (HP:0000977)1.82308249
114Late onset (HP:0003584)1.81569523
115Symptomatic seizures (HP:0011145)1.81128265
116Nephritis (HP:0000123)1.81089532
117Hammertoe (HP:0001765)1.80450472
118Mitral valve prolapse (HP:0001634)1.80044100
119Abnormality of the lacrimal duct (HP:0011481)1.78490496
120Abnormal cartilage morphology (HP:0002763)1.78395381
121Generalized aminoaciduria (HP:0002909)1.78149463
122Malnutrition (HP:0004395)1.77802304
123Right ventricular cardiomyopathy (HP:0011663)1.77635086
124Mild short stature (HP:0003502)1.77522191
125Cerebral edema (HP:0002181)1.77408388
126Alacrima (HP:0000522)1.76632297
127Absent hair (HP:0002298)1.75117695
128Renal hypoplasia (HP:0000089)1.75057699
129Abnormality of the pubic bones (HP:0003172)1.74811423
130Exercise-induced muscle cramps (HP:0003710)1.74614886
131Decreased lacrimation (HP:0000633)1.74336919
132Omphalocele (HP:0001539)1.73230120
133Cerebellar dysplasia (HP:0007033)1.72965547
134Bronchomalacia (HP:0002780)1.72904416
135Fibular hypoplasia (HP:0003038)1.72047879
136Abnormal auditory evoked potentials (HP:0006958)1.71813780
137Clitoromegaly (HP:0000057)1.71233488
138Thickened helices (HP:0000391)1.71103178
139Protuberant abdomen (HP:0001538)1.70739104
140Calcaneovalgus deformity (HP:0001848)1.70268914
141Cortical dysplasia (HP:0002539)1.69577897
142Choanal stenosis (HP:0000452)1.68888301
143Opisthotonus (HP:0002179)1.68699939
144Cutaneous finger syndactyly (HP:0010554)1.66663005
145Menorrhagia (HP:0000132)1.66191809
146Periauricular skin pits (HP:0100277)1.66167792
147Preauricular pit (HP:0004467)1.66167792
148Aplasia/Hypoplasia of the sternum (HP:0006714)1.65615446
149Pigmentary retinal degeneration (HP:0001146)1.65072547
150Renal cortical cysts (HP:0000803)1.64890870
151Spastic diplegia (HP:0001264)1.64699047
152Hyporeflexia of lower limbs (HP:0002600)1.63166663
153Bifid tongue (HP:0010297)1.63137915
154Wormian bones (HP:0002645)1.62810677
155Atrophic scars (HP:0001075)1.62673648
156Megalencephaly (HP:0001355)1.62361270
157Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62053491
158Scanning speech (HP:0002168)1.61057663
159Blue irides (HP:0000635)1.60467566
160Vertebral clefting (HP:0008428)1.59109323
161Pheochromocytoma (HP:0002666)1.58717915
162Tracheomalacia (HP:0002779)1.58597603
163Anophthalmia (HP:0000528)1.57450861
164Ectopic anus (HP:0004397)1.57183566
165Hypoplastic ischia (HP:0003175)1.56354456
166* Abnormality of the ischium (HP:0003174)1.56354456
167Aqueductal stenosis (HP:0002410)1.56234614
168Visceral angiomatosis (HP:0100761)1.56078253
169Hyperventilation (HP:0002883)1.55269502
170Congenital malformation of the right heart (HP:0011723)1.54926426
171Double outlet right ventricle (HP:0001719)1.54926426
172Abnormality of dentin (HP:0010299)1.51395760
173Bladder diverticulum (HP:0000015)1.51352460
174Arnold-Chiari malformation (HP:0002308)1.50739327
175Abnormality of the middle phalanges of the toes (HP:0010183)1.50179212
176Hemangiomatosis (HP:0007461)1.48928195
177Abnormality of the distal phalanx of the thumb (HP:0009617)1.48776976
178Anal stenosis (HP:0002025)1.48582646
179Volvulus (HP:0002580)1.47182781
180Vitreoretinal degeneration (HP:0000655)1.46619494
181Distal arthrogryposis (HP:0005684)1.45757145
182Neoplasm of the heart (HP:0100544)1.45606949
183Split foot (HP:0001839)1.45288981
184Abnormality of the left ventricular outflow tract (HP:0011103)1.45246999
185Subaortic stenosis (HP:0001682)1.45246999
186Cubitus valgus (HP:0002967)1.45183014
187Aplasia/Hypoplasia of the fibula (HP:0006492)1.43524943
188Shawl scrotum (HP:0000049)1.42978827
189Hemiparesis (HP:0001269)1.42777788
190Long clavicles (HP:0000890)1.42488387
191Broad metatarsal (HP:0001783)1.42087730
192Abnormality of the calf musculature (HP:0001430)1.41876136
193Abnormal pancreas size (HP:0012094)1.41583123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.82412875
2SIK13.45246342
3FGFR43.12460771
4INSRR2.89723104
5FRK2.70243900
6TNIK2.63273754
7MARK12.55122774
8FGFR22.48853152
9OBSCN2.41862938
10ERN12.32282852
11FER2.27777257
12EPHA32.00069812
13PNCK1.96672109
14BCR1.95603099
15CASK1.92577479
16ERBB41.85208811
17NTRK21.83784820
18SGK21.76413745
19STK391.73950921
20NTRK11.73362923
21SGK4941.64158883
22SGK2231.64158883
23PBK1.61737346
24PRKD31.60579531
25DAPK21.60068036
26STK38L1.52997720
27MAPK151.51892610
28MAP2K41.50291744
29NEK91.44854349
30SGK31.44630784
31FGFR31.43423091
32RIPK11.39029231
33MAP3K21.29650110
34TIE11.28186005
35TYK21.26425316
36EPHB11.25933205
37BRD41.25227826
38PDGFRB1.24821325
39TTN1.16632875
40JAK11.16627935
41LATS11.15770824
42LMTK21.15177159
43TAOK31.13988113
44EPHB21.11526817
45MAP2K11.11416666
46CAMK1D1.10872248
47ERBB31.09327264
48MINK11.07808042
49MST1R1.05589191
50PIK3CG1.02179116
51PTK61.00577807
52TYRO30.99862025
53MAPK110.98595278
54AKT30.97065063
55JAK20.97058110
56NTRK30.97014977
57PAK30.95835285
58MAP3K70.95076455
59EEF2K0.94979156
60MKNK20.94878158
61PKN20.94852580
62TSSK60.93391124
63FLT30.93024498
64RET0.92778859
65BMPR1B0.92447164
66NEK60.90311893
67PRKAA20.87912339
68MAP3K140.87729715
69MET0.87353184
70PRKCH0.87174199
71DMPK0.85752918
72PAK60.84523736
73ROCK20.83824961
74PINK10.83481867
75ICK0.82027639
76WNK30.81668726
77EPHA40.79530480
78WEE10.79209014
79LATS20.78332587
80ACVR1B0.77499496
81ERBB20.76325975
82PDGFRA0.76310768
83PTK20.76284684
84WNK40.75022997
85DDR20.74214751
86PRKAA10.74099669
87PHKG20.74043265
88PHKG10.74043265
89KSR10.72575544
90GSK3A0.72234659
91PRKCZ0.71761392
92TGFBR20.70325851
93KSR20.68753206
94YES10.68022989
95MAP3K100.67553413
96CAMK2B0.67415297
97PRKCG0.67007042
98PRKACG0.65877543
99MOS0.64179644
100MKNK10.63892919
101TRIB30.63204353
102PAK20.62451989
103* MAPK100.62220135
104CDC42BPA0.62026467
105CAMK2G0.61764552
106NLK0.61092307
107PLK20.59371223
108CAMK2D0.57975824
109SIK30.57677058
110IGF1R0.57588404
111OXSR10.57562147
112KDR0.57439594
113RPS6KA20.57290728
114PDK20.56525431
115FGFR10.55431951
116RPS6KB10.53383255
117PRKCE0.52785577
118PDPK10.52474468
119CAMK1G0.51321634
120PKN10.50886386
121CAMK2A0.50812056
122IRAK10.50776822
123MAPK120.50771945
124CAMK40.50695207
125CDK50.50681444
126STK30.50646659
127MAP3K30.49982382
128ADRBK10.49842712
129PLK40.49518279
130BRSK20.49491941
131MELK0.48228255
132PIK3CA0.47994031
133SCYL20.47260517
134GRK50.47199546
135CSNK1G20.47173708
136CSNK1G10.46940499
137UHMK10.46390929
138MAPK130.45243271
139MAP2K70.45111368
140ROCK10.44326449
141MAPK70.43362301
142NEK20.43317265
143TGFBR10.43019687
144MAP3K10.40872978
145MAP3K40.39921610
146MAPKAPK30.39843416
147PRKACB0.39738564
148MATK0.38975265
149PRKD10.38548889
150PDK30.34307046
151PDK40.34307046
152MTOR0.34015311

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.27240754
2Nitrogen metabolism_Homo sapiens_hsa009103.61776809
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27805129
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.90838020
5Arginine biosynthesis_Homo sapiens_hsa002202.79655486
6Complement and coagulation cascades_Homo sapiens_hsa046102.79104991
7Fatty acid degradation_Homo sapiens_hsa000712.67889103
8Tryptophan metabolism_Homo sapiens_hsa003802.64980758
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.59453073
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49713229
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.46701041
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19862058
13Propanoate metabolism_Homo sapiens_hsa006402.09364914
14Fatty acid metabolism_Homo sapiens_hsa012122.06286789
15Peroxisome_Homo sapiens_hsa041462.05515756
16Adherens junction_Homo sapiens_hsa045202.05456372
17Butanoate metabolism_Homo sapiens_hsa006502.03165674
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.94941759
19PPAR signaling pathway_Homo sapiens_hsa033201.94739143
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85096895
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83568245
22Hippo signaling pathway_Homo sapiens_hsa043901.79504906
23Focal adhesion_Homo sapiens_hsa045101.74549431
24Dilated cardiomyopathy_Homo sapiens_hsa054141.73845143
25Sulfur metabolism_Homo sapiens_hsa009201.73357421
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.70438395
27Histidine metabolism_Homo sapiens_hsa003401.69408832
28Basal cell carcinoma_Homo sapiens_hsa052171.69083735
29Chemical carcinogenesis_Homo sapiens_hsa052041.66596553
30TGF-beta signaling pathway_Homo sapiens_hsa043501.65025978
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63085818
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.62787457
33Caffeine metabolism_Homo sapiens_hsa002321.61708272
34Staphylococcus aureus infection_Homo sapiens_hsa051501.59346459
35beta-Alanine metabolism_Homo sapiens_hsa004101.56555778
36Bile secretion_Homo sapiens_hsa049761.56418892
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56276129
38Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54822982
39Hedgehog signaling pathway_Homo sapiens_hsa043401.50129088
40Axon guidance_Homo sapiens_hsa043601.48214457
41Nicotine addiction_Homo sapiens_hsa050331.45763279
42Phenylalanine metabolism_Homo sapiens_hsa003601.44897908
43Circadian entrainment_Homo sapiens_hsa047131.44011447
44Retinol metabolism_Homo sapiens_hsa008301.43440854
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.42566003
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.41839287
47Fatty acid elongation_Homo sapiens_hsa000621.41770712
48Tight junction_Homo sapiens_hsa045301.38373547
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.37637719
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37199401
51Pyruvate metabolism_Homo sapiens_hsa006201.36591834
52Steroid biosynthesis_Homo sapiens_hsa001001.35205201
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.34349520
54Tyrosine metabolism_Homo sapiens_hsa003501.32849469
55Melanogenesis_Homo sapiens_hsa049161.31039897
56* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30518691
57Long-term potentiation_Homo sapiens_hsa047201.29854520
58Glutamatergic synapse_Homo sapiens_hsa047241.28840049
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28574901
60Selenocompound metabolism_Homo sapiens_hsa004501.28215366
61ABC transporters_Homo sapiens_hsa020101.27656189
62Starch and sucrose metabolism_Homo sapiens_hsa005001.24597528
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22832546
64Gap junction_Homo sapiens_hsa045401.22663882
65Fatty acid biosynthesis_Homo sapiens_hsa000611.21828594
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.20096531
67Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19266225
68Renin secretion_Homo sapiens_hsa049241.18237293
69Fat digestion and absorption_Homo sapiens_hsa049751.16465386
70Wnt signaling pathway_Homo sapiens_hsa043101.16078797
71Gastric acid secretion_Homo sapiens_hsa049711.14564717
72Proteoglycans in cancer_Homo sapiens_hsa052051.13309319
73Circadian rhythm_Homo sapiens_hsa047101.11189426
74cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10709420
75cAMP signaling pathway_Homo sapiens_hsa040241.09291520
76MicroRNAs in cancer_Homo sapiens_hsa052061.06844233
77Cyanoamino acid metabolism_Homo sapiens_hsa004601.03685804
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03510759
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03282060
80GABAergic synapse_Homo sapiens_hsa047271.02179077
81Morphine addiction_Homo sapiens_hsa050321.01096564
82Vascular smooth muscle contraction_Homo sapiens_hsa042701.00754797
83Glioma_Homo sapiens_hsa052141.00455063
84Dopaminergic synapse_Homo sapiens_hsa047280.97624213
85Rap1 signaling pathway_Homo sapiens_hsa040150.97065239
86Amphetamine addiction_Homo sapiens_hsa050310.96708651
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96687295
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96366208
89Small cell lung cancer_Homo sapiens_hsa052220.95578531
90AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94799529
91Estrogen signaling pathway_Homo sapiens_hsa049150.94616047
92Endometrial cancer_Homo sapiens_hsa052130.93621228
93Oxytocin signaling pathway_Homo sapiens_hsa049210.90783100
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.90187377
95Cholinergic synapse_Homo sapiens_hsa047250.90145204
96Arginine and proline metabolism_Homo sapiens_hsa003300.89909749
97Colorectal cancer_Homo sapiens_hsa052100.88244495
98Carbon metabolism_Homo sapiens_hsa012000.88120428
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.87336232
100Renal cell carcinoma_Homo sapiens_hsa052110.86390269
101ErbB signaling pathway_Homo sapiens_hsa040120.85771066
102Folate biosynthesis_Homo sapiens_hsa007900.84491619
103Pathways in cancer_Homo sapiens_hsa052000.83958139
104Biosynthesis of amino acids_Homo sapiens_hsa012300.83373784
105Salivary secretion_Homo sapiens_hsa049700.80494926
106Glycerolipid metabolism_Homo sapiens_hsa005610.80403301
107Vitamin digestion and absorption_Homo sapiens_hsa049770.79122204
108Long-term depression_Homo sapiens_hsa047300.77274367
109Cocaine addiction_Homo sapiens_hsa050300.76379671
110Calcium signaling pathway_Homo sapiens_hsa040200.75645073
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.75452022
112Lysine degradation_Homo sapiens_hsa003100.74569761
113Choline metabolism in cancer_Homo sapiens_hsa052310.73087184
114Vitamin B6 metabolism_Homo sapiens_hsa007500.70095608
115GnRH signaling pathway_Homo sapiens_hsa049120.69749488
116Ras signaling pathway_Homo sapiens_hsa040140.63824295
117Taste transduction_Homo sapiens_hsa047420.63047399
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61467180
119Oocyte meiosis_Homo sapiens_hsa041140.61133975
120Prion diseases_Homo sapiens_hsa050200.60772413
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59663759
122Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58498833
123Alcoholism_Homo sapiens_hsa050340.57542736
124Prostate cancer_Homo sapiens_hsa052150.57253175
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56048323
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55111987
127Chronic myeloid leukemia_Homo sapiens_hsa052200.54409874
128Melanoma_Homo sapiens_hsa052180.54018129
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52678533
130Inositol phosphate metabolism_Homo sapiens_hsa005620.51749035
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46419789
132Insulin resistance_Homo sapiens_hsa049310.44504099
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.39214880
134Metabolic pathways_Homo sapiens_hsa011000.33689461
135Glutathione metabolism_Homo sapiens_hsa004800.32245719
136Glucagon signaling pathway_Homo sapiens_hsa049220.30872980
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24407744
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22339678
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.20050698
140Sulfur relay system_Homo sapiens_hsa041220.19572946
141One carbon pool by folate_Homo sapiens_hsa006700.18538069
142Insulin signaling pathway_Homo sapiens_hsa049100.14454786
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13970875
144Protein digestion and absorption_Homo sapiens_hsa049740.13011644
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.11379893
146Renin-angiotensin system_Homo sapiens_hsa046140.10460942
147Linoleic acid metabolism_Homo sapiens_hsa005910.09191666
148AMPK signaling pathway_Homo sapiens_hsa041520.08940168
149Pentose phosphate pathway_Homo sapiens_hsa000300.08464899
150Galactose metabolism_Homo sapiens_hsa000520.08215855
151Thyroid hormone synthesis_Homo sapiens_hsa049180.07923851
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07161218
153Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06320956
154Fructose and mannose metabolism_Homo sapiens_hsa000510.05359962
155Insulin secretion_Homo sapiens_hsa049110.03155920
156Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.02202124
157Type II diabetes mellitus_Homo sapiens_hsa049300.01234925
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.00794796
159Regulation of autophagy_Homo sapiens_hsa041400.00140485
160Ovarian steroidogenesis_Homo sapiens_hsa049130.00078190
161Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0586256
162African trypanosomiasis_Homo sapiens_hsa05143-0.0580882
163Pancreatic secretion_Homo sapiens_hsa04972-0.0498802
164Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0485801
165Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532-0.0480219
166Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0395220
167ECM-receptor interaction_Homo sapiens_hsa04512-0.0027441
168Amoebiasis_Homo sapiens_hsa05146-0.0003115

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