LHX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1post-embryonic morphogenesis (GO:0009886)9.05642722
2neuron projection extension involved in neuron projection guidance (GO:1902284)8.00145594
3axon extension involved in axon guidance (GO:0048846)8.00145594
4neurofilament cytoskeleton organization (GO:0060052)7.96384912
5peptidyl-arginine omega-N-methylation (GO:0035247)7.47318674
6negative regulation of phosphoprotein phosphatase activity (GO:0032515)7.12667866
7regulation of chemokine-mediated signaling pathway (GO:0070099)6.78467617
8adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.76753499
9peptidyl-arginine methylation (GO:0018216)6.68012324
10peptidyl-arginine N-methylation (GO:0035246)6.68012324
11cellular response to ATP (GO:0071318)6.61640646
12histone arginine methylation (GO:0034969)6.39973586
13response to parathyroid hormone (GO:0071107)6.30518018
14behavioral response to nicotine (GO:0035095)6.18570861
15negative regulation of translational initiation (GO:0045947)5.82529527
16* motor neuron axon guidance (GO:0008045)5.72857394
17detection of light stimulus involved in visual perception (GO:0050908)5.60926947
18detection of light stimulus involved in sensory perception (GO:0050962)5.60926947
19retinal rod cell development (GO:0046548)5.50776041
20body morphogenesis (GO:0010171)5.43691452
21protein maturation by protein folding (GO:0022417)5.42700396
22response to pheromone (GO:0019236)5.42375667
23negative regulation of axon guidance (GO:1902668)5.10453602
24negative regulation of astrocyte differentiation (GO:0048712)5.03390956
25pre-miRNA processing (GO:0031054)5.00489721
26cardiac right ventricle morphogenesis (GO:0003215)4.98171917
27mating behavior (GO:0007617)4.88153325
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.82789913
29diaphragm development (GO:0060539)4.81968884
30neuronal action potential propagation (GO:0019227)4.81719206
31retinal ganglion cell axon guidance (GO:0031290)4.79551608
32negative regulation of leukocyte chemotaxis (GO:0002689)4.78171698
33negative regulation of multicellular organism growth (GO:0040015)4.77715394
34skeletal muscle organ development (GO:0060538)4.65795938
35chemosensory behavior (GO:0007635)4.53940285
36sarcoplasmic reticulum calcium ion transport (GO:0070296)4.35864683
37cellular response to prostaglandin stimulus (GO:0071379)4.35698269
38nucleobase catabolic process (GO:0046113)4.32298960
39negative regulation of calcium ion transport into cytosol (GO:0010523)4.30996607
40GMP metabolic process (GO:0046037)4.30234795
41adrenergic receptor signaling pathway (GO:0071875)4.27624051
42protein localization to synapse (GO:0035418)4.20779275
43positive regulation of uterine smooth muscle contraction (GO:0070474)4.17197574
44synaptic transmission, cholinergic (GO:0007271)4.16891052
45positive regulation of cAMP-mediated signaling (GO:0043950)4.16659704
46viral mRNA export from host cell nucleus (GO:0046784)4.16274528
47tachykinin receptor signaling pathway (GO:0007217)4.14274732
48peptidyl-arginine modification (GO:0018195)4.10017105
49neuromuscular synaptic transmission (GO:0007274)4.09649042
50urinary tract smooth muscle contraction (GO:0014848)4.08634255
51ectodermal placode formation (GO:0060788)3.95166992
52auditory receptor cell differentiation (GO:0042491)3.94340698
53negative regulation of glial cell differentiation (GO:0045686)3.93094318
54calcium-mediated signaling using intracellular calcium source (GO:0035584)3.89530957
55respiratory system process (GO:0003016)3.86719330
56L-glutamate transport (GO:0015813)3.86704923
57peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.84766452
58ribosomal small subunit biogenesis (GO:0042274)3.83981373
59negative regulation of heart rate (GO:0010459)3.81207056
60viral transcription (GO:0019083)3.80883009
61nerve development (GO:0021675)3.79549882
62translational termination (GO:0006415)3.78889463
63* neuron fate specification (GO:0048665)3.69394194
64acidic amino acid transport (GO:0015800)3.67802256
65positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.66901007
66cellular potassium ion homeostasis (GO:0030007)3.64908782
67regulation of mitotic spindle checkpoint (GO:1903504)3.63477700
68regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.63477700
69regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.62517107
70photoreceptor cell development (GO:0042461)3.62346091
71negative regulation of vascular permeability (GO:0043116)3.62314505
72hyperosmotic salinity response (GO:0042538)3.61599534
73sleep (GO:0030431)3.55486848
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55146926
75positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.52590768
76regulation of protein heterodimerization activity (GO:0043497)3.50473350
77negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.50057765
78synaptic vesicle exocytosis (GO:0016079)3.49062568
79neuromuscular process controlling posture (GO:0050884)3.48311432
80cellular response to glucagon stimulus (GO:0071377)3.42838419
81eye photoreceptor cell development (GO:0042462)3.42209674
82retina layer formation (GO:0010842)3.41955978
83outer ear morphogenesis (GO:0042473)3.41500639
84neuronal stem cell maintenance (GO:0097150)3.40537724
85response to prostaglandin E (GO:0034695)3.37338359
86regulation of cardioblast proliferation (GO:0003264)3.36215100
87regulation of secondary heart field cardioblast proliferation (GO:0003266)3.36215100
88regulation of axon guidance (GO:1902667)3.34640089
89negative regulation of microtubule polymerization (GO:0031115)3.30837385
90innervation (GO:0060384)3.29400001
91single strand break repair (GO:0000012)3.28353979
92atrial septum morphogenesis (GO:0060413)3.28253190
93inner ear receptor cell differentiation (GO:0060113)3.28211754
94retinal cone cell development (GO:0046549)3.27573127
95mitochondrial fusion (GO:0008053)3.24328771
96cAMP biosynthetic process (GO:0006171)3.24194853
97regulation of uterine smooth muscle contraction (GO:0070472)3.23731268
98pyrimidine nucleotide catabolic process (GO:0006244)3.23557576
99calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.21214467
100pyrimidine nucleobase catabolic process (GO:0006208)3.20384990
101layer formation in cerebral cortex (GO:0021819)3.19417741
102protein localization to kinetochore (GO:0034501)3.19209856
103regulation of catecholamine metabolic process (GO:0042069)3.19170136
104regulation of dopamine metabolic process (GO:0042053)3.19170136
105cellular response to electrical stimulus (GO:0071257)3.17988227
106nodal signaling pathway (GO:0038092)3.17186370
107positive regulation of receptor biosynthetic process (GO:0010870)3.16688785
108IMP biosynthetic process (GO:0006188)3.13615444
109negative regulation of smooth muscle cell migration (GO:0014912)3.13235936
110membrane hyperpolarization (GO:0060081)3.11652051
111translational elongation (GO:0006414)3.11157854
112visual perception (GO:0007601)3.10872076
113sensory perception of light stimulus (GO:0050953)3.08592935
114negative chemotaxis (GO:0050919)3.08089305
115negative regulation of gliogenesis (GO:0014014)3.07897058
116positive regulation of dendritic spine morphogenesis (GO:0061003)3.06192584
117positive regulation of cell cycle checkpoint (GO:1901978)3.05199461
118nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.05024901
119cellular protein complex disassembly (GO:0043624)3.02579740
120intra-S DNA damage checkpoint (GO:0031573)3.00644281
121spliceosomal snRNP assembly (GO:0000387)2.93945185
122potassium ion homeostasis (GO:0055075)2.93027281
123activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.92988831
124pyrimidine ribonucleoside catabolic process (GO:0046133)2.92687043
125protein localization to chromosome, centromeric region (GO:0071459)2.91965638
126protein targeting to ER (GO:0045047)2.91380407
127cotranslational protein targeting to membrane (GO:0006613)2.91076324
128regulation of mononuclear cell migration (GO:0071675)2.91037096
129G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90710871
130SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.90200957
131response to glucagon (GO:0033762)2.89319466
132response to dietary excess (GO:0002021)2.88956072
133viral life cycle (GO:0019058)2.87019792
134regulation of axon regeneration (GO:0048679)2.85297008
135regulation of neuron projection regeneration (GO:0070570)2.85297008
136genetic imprinting (GO:0071514)2.85021946
137retina development in camera-type eye (GO:0060041)2.82102091
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.81858263
139regulation of DNA damage checkpoint (GO:2000001)2.80871761
140dopamine receptor signaling pathway (GO:0007212)2.80562105
141endocardial cushion morphogenesis (GO:0003203)2.80326827
142hair cell differentiation (GO:0035315)2.79594540
143establishment of protein localization to endoplasmic reticulum (GO:0072599)2.78093037
144establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.77761378
145mitochondrion transport along microtubule (GO:0047497)2.77761378
146protein complex disassembly (GO:0043241)2.77438668
147neuroblast proliferation (GO:0007405)2.76472942
148muscle cell cellular homeostasis (GO:0046716)2.75267327
149regulation of action potential (GO:0098900)2.74473697
150homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.74220418
151cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.73976321
152photoreceptor cell maintenance (GO:0045494)2.73876093
153regulation of spindle checkpoint (GO:0090231)2.72955162
154regulation of centriole replication (GO:0046599)2.72735584
155protein localization to endoplasmic reticulum (GO:0070972)2.71128195
156translational initiation (GO:0006413)2.70992355
157positive regulation of gastrulation (GO:2000543)2.70899563
158cranial nerve structural organization (GO:0021604)2.70755505
159protein neddylation (GO:0045116)2.70567539
160rRNA catabolic process (GO:0016075)2.69798886
161axon regeneration (GO:0031103)2.69530735
162regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.69279747
163histone H3-K9 methylation (GO:0051567)2.68996241
164regulation of feeding behavior (GO:0060259)2.68652796
165negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.68651016
166macromolecular complex disassembly (GO:0032984)2.67731172
167response to vitamin E (GO:0033197)2.67565797
168myoblast differentiation (GO:0045445)2.67323689
169peristalsis (GO:0030432)2.66412914
170response to redox state (GO:0051775)2.66296317
171C4-dicarboxylate transport (GO:0015740)2.65208305
172cranial nerve morphogenesis (GO:0021602)2.64884136
173ATP synthesis coupled proton transport (GO:0015986)2.64863247
174energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64863247
175deoxyribose phosphate biosynthetic process (GO:0046385)2.63839461
1762-deoxyribonucleotide biosynthetic process (GO:0009265)2.63839461
177synapse assembly (GO:0007416)2.62408679
178DNA unwinding involved in DNA replication (GO:0006268)2.62142749
179axon extension (GO:0048675)2.59811494
180negative regulation of axon extension (GO:0030517)2.57336054
181synaptic vesicle endocytosis (GO:0048488)2.54595952
182cranial nerve development (GO:0021545)2.52831096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.78461107
2EZH2_22144423_ChIP-Seq_EOC_Human4.42901078
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.27205042
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.21300514
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.02344329
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.50402741
7GBX2_23144817_ChIP-Seq_PC3_Human3.37627831
8GATA1_22025678_ChIP-Seq_K562_Human3.29286695
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.18257610
10E2F7_22180533_ChIP-Seq_HELA_Human2.78262278
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.70165285
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67762653
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54158801
14* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.52174288
15TAF15_26573619_Chip-Seq_HEK293_Human2.50720326
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41694979
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.38432898
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.21778929
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.10038850
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.09568270
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.07039597
22* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.03925524
23* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01976768
24PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.00467798
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94950814
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92191475
27RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92191475
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90337743
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89987053
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87562752
31* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86814076
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81418694
33WDR5_24793694_ChIP-Seq_LNCAP_Human1.78167624
34REST_21632747_ChIP-Seq_MESCs_Mouse1.77344063
35CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.76833999
36* ERG_21242973_ChIP-ChIP_JURKAT_Human1.76653819
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.75990554
38* RING1B_27294783_Chip-Seq_ESCs_Mouse1.75437316
39PKCTHETA_26484144_Chip-Seq_BREAST_Human1.70578156
40* RNF2_27304074_Chip-Seq_ESCs_Mouse1.70074681
41* CBX2_27304074_Chip-Seq_ESCs_Mouse1.68651233
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67599019
43RNF2_27304074_Chip-Seq_NSC_Mouse1.65547664
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60519793
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60017232
46* REST_18959480_ChIP-ChIP_MESCs_Mouse1.59560747
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56878558
48* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56694002
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52196418
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52175381
51DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50815468
52OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.48948620
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48289318
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46920075
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.46540214
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45493281
57AR_21909140_ChIP-Seq_LNCAP_Human1.44766110
58XRN2_22483619_ChIP-Seq_HELA_Human1.43817174
59GATA1_26923725_Chip-Seq_HPCs_Mouse1.43503131
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.42526153
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40720751
62VDR_22108803_ChIP-Seq_LS180_Human1.40250218
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40092230
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39038820
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.38967766
66P300_19829295_ChIP-Seq_ESCs_Human1.38313988
67* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37522893
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.37285376
69KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37139105
70CTCF_27219007_Chip-Seq_Bcells_Human1.36316711
71KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35763588
72KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35763588
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35763588
74EWS_26573619_Chip-Seq_HEK293_Human1.35100464
75MYC_18555785_ChIP-Seq_MESCs_Mouse1.32843266
76POU3F2_20337985_ChIP-ChIP_501MEL_Human1.31246924
77SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29787524
78* RING1B_27294783_Chip-Seq_NPCs_Mouse1.29420428
79ETV1_20927104_ChIP-Seq_GIST48_Human1.28411530
80HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28387026
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26992057
82FUS_26573619_Chip-Seq_HEK293_Human1.26453869
83* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25163428
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.24086683
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.23009634
86* SMC4_20622854_ChIP-Seq_HELA_Human1.21826134
87SOX3_22085726_ChIP-Seq_NPCs_Mouse1.21731547
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21248148
89* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21186852
90* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20559719
91TBL1_22424771_ChIP-Seq_293T_Human1.20175015
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18889204
93THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18237409
94* KDM2B_26808549_Chip-Seq_K562_Human1.18010335
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15579124
96DROSHA_22980978_ChIP-Seq_HELA_Human1.15556773
97RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15070490
98CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13992586
99ELK4_26923725_Chip-Seq_MESODERM_Mouse1.13835201
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11546267
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.09636430
102CBP_21632823_ChIP-Seq_H3396_Human1.09160216
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08578653
104PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08135003
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07323679
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06764716
107POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.06761993
108FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.06252779
109ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06022719
110YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05914908
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04812744
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04674435
113ISL1_27105846_Chip-Seq_CPCs_Mouse1.03249297
114SA1_27219007_Chip-Seq_Bcells_Human1.03139539
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02927816
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02927816
117KDM2B_26808549_Chip-Seq_JURKAT_Human1.02575696
118KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02038829
119IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01001793
120SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00627119
121CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.99973624
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98566822
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98525678
124TCF4_18268006_ChIP-ChIP_LS174T_Human0.98267270
125ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97724398
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.97613201
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.97360970
128BCAT_22108803_ChIP-Seq_LS180_Human0.96991959
129TOP2B_26459242_ChIP-Seq_MCF-7_Human0.96767067
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96668801
131NFYB_21822215_ChIP-Seq_K562_Human0.96209755
132AR_25329375_ChIP-Seq_VCAP_Human0.96139837
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94785352
134EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94386471
135TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94197463
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93458019
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93120445
138TAL1_26923725_Chip-Seq_HPCs_Mouse0.92988422
139MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92641091
140E2F4_17652178_ChIP-ChIP_JURKAT_Human0.91562785
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91528815
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91001650
143SMAD4_21799915_ChIP-Seq_A2780_Human0.90824013
144* NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90543317
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89261760
146SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.89137887
147HTT_18923047_ChIP-ChIP_STHdh_Human0.88735166
148MYC_22102868_ChIP-Seq_BL_Human0.88450209
149POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87630628
150TP53_16413492_ChIP-PET_HCT116_Human0.87485806
151TTF2_22483619_ChIP-Seq_HELA_Human0.87192693
152SOX9_26525672_Chip-Seq_HEART_Mouse0.87004074
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86920061
154MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.86869438
155* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86671138
156SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.85277580
157HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.85164980
158TCF3_18692474_ChIP-Seq_MESCs_Mouse0.84455356
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.83691387
160AR_19668381_ChIP-Seq_PC3_Human0.83505997
161PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83016978
162OCT4_19829295_ChIP-Seq_ESCs_Human0.82727212

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001986_abnormal_taste_sensitivity6.24883516
2MP0010386_abnormal_urinary_bladder4.73106981
3MP0003011_delayed_dark_adaptation4.64645581
4MP0008789_abnormal_olfactory_epithelium4.38234925
5MP0005394_taste/olfaction_phenotype3.74177206
6MP0005499_abnormal_olfactory_system3.74177206
7MP0003950_abnormal_plasma_membrane3.69793369
8MP0005551_abnormal_eye_electrophysiolog3.62606309
9MP0002638_abnormal_pupillary_reflex3.40522660
10MP0005248_abnormal_Harderian_gland3.36784876
11MP0005423_abnormal_somatic_nervous3.04377799
12MP0006072_abnormal_retinal_apoptosis2.81979171
13MP0005253_abnormal_eye_physiology2.77635697
14MP0010030_abnormal_orbit_morphology2.76181758
15MP0002184_abnormal_innervation2.55269237
16MP0000566_synostosis2.53870303
17MP0003879_abnormal_hair_cell2.46566409
18MP0001502_abnormal_circadian_rhythm1.99355245
19MP0003880_abnormal_central_pattern1.92025609
20MP0003567_abnormal_fetal_cardiomyocyte1.90526378
21MP0000569_abnormal_digit_pigmentation1.82031022
22* MP0002752_abnormal_somatic_nervous1.77470245
23MP0002234_abnormal_pharynx_morphology1.73105673
24MP0001529_abnormal_vocalization1.73077705
25MP0005195_abnormal_posterior_eye1.72734153
26MP0004133_heterotaxia1.69726816
27MP0001485_abnormal_pinna_reflex1.65050778
28MP0002751_abnormal_autonomic_nervous1.64954830
29MP0000534_abnormal_ureter_morphology1.64356610
30MP0002233_abnormal_nose_morphology1.55452952
31MP0000026_abnormal_inner_ear1.53655799
32MP0004924_abnormal_behavior1.51673074
33MP0005386_behavior/neurological_phenoty1.51673074
34MP0003942_abnormal_urinary_system1.50661979
35* MP0000955_abnormal_spinal_cord1.44137925
36MP0000778_abnormal_nervous_system1.43873035
37MP0006292_abnormal_olfactory_placode1.40287412
38MP0005197_abnormal_uvea_morphology1.38867777
39MP0005391_vision/eye_phenotype1.38317807
40MP0002009_preneoplasia1.37849460
41MP0003635_abnormal_synaptic_transmissio1.37136248
42MP0004858_abnormal_nervous_system1.35240827
43MP0006276_abnormal_autonomic_nervous1.33733548
44MP0004270_analgesia1.33199171
45* MP0002882_abnormal_neuron_morphology1.32292766
46MP0003119_abnormal_digestive_system1.30483382
47MP0001346_abnormal_lacrimal_gland1.30172580
48MP0000003_abnormal_adipose_tissue1.27575806
49MP0004142_abnormal_muscle_tone1.26905682
50MP0008995_early_reproductive_senescence1.26012104
51MP0003938_abnormal_ear_development1.25539218
52MP0001963_abnormal_hearing_physiology1.25044635
53MP0004130_abnormal_muscle_cell1.20905909
54MP0005187_abnormal_penis_morphology1.20895818
55MP0005645_abnormal_hypothalamus_physiol1.19667346
56MP0001486_abnormal_startle_reflex1.18520522
57MP0003787_abnormal_imprinting1.17400878
58MP0003121_genomic_imprinting1.15364519
59MP0004859_abnormal_synaptic_plasticity1.13318189
60MP0003890_abnormal_embryonic-extraembry1.12836348
61MP0004233_abnormal_muscle_weight1.11907472
62MP0004742_abnormal_vestibular_system1.11485776
63MP0002272_abnormal_nervous_system1.10034393
64MP0003123_paternal_imprinting1.09066358
65MP0008877_abnormal_DNA_methylation1.08059879
66MP0002063_abnormal_learning/memory/cond1.06460741
67MP0002229_neurodegeneration1.06330651
68MP0001177_atelectasis1.05871535
69MP0003861_abnormal_nervous_system1.04272806
70MP0008872_abnormal_physiological_respon1.04062565
71MP0003315_abnormal_perineum_morphology1.03220394
72MP0004811_abnormal_neuron_physiology1.03153655
73MP0001984_abnormal_olfaction1.01806337
74MP0001968_abnormal_touch/_nociception1.00882232
75MP0001324_abnormal_eye_pigmentation0.99742157
76MP0003122_maternal_imprinting0.99372925
77MP0004145_abnormal_muscle_electrophysio0.98578068
78MP0009046_muscle_twitch0.97476976
79MP0002909_abnormal_adrenal_gland0.97316066
80* MP0000631_abnormal_neuroendocrine_gland0.96713907
81MP0002067_abnormal_sensory_capabilities0.96553166
82MP0004782_abnormal_surfactant_physiolog0.94982585
83MP0008775_abnormal_heart_ventricle0.94743622
84MP0002735_abnormal_chemical_nociception0.93445928
85MP0009115_abnormal_fat_cell0.92857578
86MP0001286_abnormal_eye_development0.90727117
87MP0003868_abnormal_feces_composition0.90419994
88MP0002734_abnormal_mechanical_nocicepti0.89146211
89MP0005670_abnormal_white_adipose0.87369681
90MP0002090_abnormal_vision0.87067888
91MP0008057_abnormal_DNA_replication0.84827755
92MP0000428_abnormal_craniofacial_morphol0.84571088
93MP0001188_hyperpigmentation0.84306462
94MP0001970_abnormal_pain_threshold0.80017918
95MP0003111_abnormal_nucleus_morphology0.78923281
96MP0003385_abnormal_body_wall0.78808240
97MP0002822_catalepsy0.78145502
98MP0008961_abnormal_basal_metabolism0.77887591
99MP0002108_abnormal_muscle_morphology0.77600483
100MP0005448_abnormal_energy_balance0.77174856
101MP0004036_abnormal_muscle_relaxation0.75833860
102MP0005220_abnormal_exocrine_pancreas0.75535095
103MP0003077_abnormal_cell_cycle0.74841993
104* MP0002081_perinatal_lethality0.73443922
105* MP0002152_abnormal_brain_morphology0.73363514
106MP0005334_abnormal_fat_pad0.72929130
107MP0000427_abnormal_hair_cycle0.72708274
108MP0002733_abnormal_thermal_nociception0.72518884
109MP0005646_abnormal_pituitary_gland0.72019875
110MP0003959_abnormal_lean_body0.71951025
111MP0000538_abnormal_urinary_bladder0.71588392
112MP0004197_abnormal_fetal_growth/weight/0.71262246
113MP0003943_abnormal_hepatobiliary_system0.71099264
114MP0003878_abnormal_ear_physiology0.69995896
115MP0005377_hearing/vestibular/ear_phenot0.69995896
116MP0001764_abnormal_homeostasis0.68313261
117MP0003137_abnormal_impulse_conducting0.68010177
118MP0010094_abnormal_chromosome_stability0.67752604
119MP0002736_abnormal_nociception_after0.67104768
120MP0000049_abnormal_middle_ear0.66162548
121MP0000350_abnormal_cell_proliferation0.65624043
122MP0002064_seizures0.65267062
123MP0003283_abnormal_digestive_organ0.63638665
124MP0002085_abnormal_embryonic_tissue0.63591576
125MP0002177_abnormal_outer_ear0.62660887
126MP0002697_abnormal_eye_size0.62609242
127MP0009672_abnormal_birth_weight0.61527404
128MP0009250_abnormal_appendicular_skeleto0.60377413
129MP0001293_anophthalmia0.59557693
130MP0002572_abnormal_emotion/affect_behav0.59555378
131MP0005375_adipose_tissue_phenotype0.59498722
132MP0001944_abnormal_pancreas_morphology0.59482785
133MP0002066_abnormal_motor_capabilities/c0.59050720
134MP0002557_abnormal_social/conspecific_i0.58041242
135MP0000470_abnormal_stomach_morphology0.57249648
136MP0001915_intracranial_hemorrhage0.57038036
137MP0002084_abnormal_developmental_patter0.56521670
138MP0002970_abnormal_white_adipose0.56409563
139MP0009745_abnormal_behavioral_response0.56337959
140MP0009053_abnormal_anal_canal0.55808489
141MP0002102_abnormal_ear_morphology0.53917097
142MP0002092_abnormal_eye_morphology0.51222524

Predicted human phenotypes

RankGene SetZ-score
1Septate vagina (HP:0001153)7.59067655
2Rectal fistula (HP:0100590)6.55838644
3Rectovaginal fistula (HP:0000143)6.55838644
4Congenital stationary night blindness (HP:0007642)6.00622118
5Intestinal fistula (HP:0100819)5.93999364
6Polar cataract (HP:0010696)5.78207779
7Intestinal atresia (HP:0011100)5.74911500
8Vaginal fistula (HP:0004320)5.65951469
9Depressed nasal tip (HP:0000437)5.51376091
10Menstrual irregularities (HP:0000858)5.48011950
11Hyperthyroidism (HP:0000836)5.29541925
12Chorioretinal atrophy (HP:0000533)5.20657195
13Severe visual impairment (HP:0001141)5.04980090
14Bicornuate uterus (HP:0000813)4.96738045
15Annular pancreas (HP:0001734)4.95001871
16Abnormality of the phalanges of the 2nd finger (HP:0009541)4.92172972
17Constricted visual fields (HP:0001133)4.81710837
18Aplasia/Hypoplasia of the sacrum (HP:0008517)4.79326619
19Enlarged penis (HP:0000040)4.49312207
20Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.31683581
21Esophageal atresia (HP:0002032)4.29244701
22Anal stenosis (HP:0002025)4.27643414
23Papillary thyroid carcinoma (HP:0002895)4.23164203
24Pigmentary retinal degeneration (HP:0001146)4.22369717
25Central scotoma (HP:0000603)3.91913664
26Keratoconus (HP:0000563)3.91542129
27Increased corneal curvature (HP:0100692)3.91542129
28Bony spicule pigmentary retinopathy (HP:0007737)3.84059327
29Decreased central vision (HP:0007663)3.63748987
30Pendular nystagmus (HP:0012043)3.50847733
31Asplenia (HP:0001746)3.50332696
32Agitation (HP:0000713)3.44103655
33Abnormality of macular pigmentation (HP:0008002)3.40249176
34Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.37239433
35Abnormal rod and cone electroretinograms (HP:0008323)3.34078177
36Abnormality of the vocal cords (HP:0008777)3.18022158
37Growth hormone excess (HP:0000845)3.16752524
38Aplasia/Hypoplasia of the spleen (HP:0010451)3.12802431
39Hepatoblastoma (HP:0002884)3.10858517
40Abnormality of the 2nd finger (HP:0004100)3.09389336
41Lower limb asymmetry (HP:0100559)3.07244950
42Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.03462353
43Cerebral hypomyelination (HP:0006808)3.02629348
44Scotoma (HP:0000575)3.02142987
45Abnormality of cells of the erythroid lineage (HP:0012130)3.00043080
46Vertebral arch anomaly (HP:0008438)2.89328886
47Abdominal situs inversus (HP:0003363)2.82382783
48Abnormality of abdominal situs (HP:0011620)2.82382783
49Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.78276567
50* Septo-optic dysplasia (HP:0100842)2.70342822
51Dyschromatopsia (HP:0007641)2.67017421
52Bifid scrotum (HP:0000048)2.66889935
53Truncal obesity (HP:0001956)2.64435642
54Horseshoe kidney (HP:0000085)2.61627004
55Absent rod-and cone-mediated responses on ERG (HP:0007688)2.60642252
56Abnormality of the labia majora (HP:0012881)2.60417326
57Testicular neoplasm (HP:0010788)2.54811616
58Abnormality of the phalanges of the 5th finger (HP:0004213)2.53536418
59Optic disc pallor (HP:0000543)2.53328489
60Germ cell neoplasia (HP:0100728)2.52079209
61Gastrointestinal atresia (HP:0002589)2.49455330
62Abnormal number of incisors (HP:0011064)2.49305740
63Thyroid carcinoma (HP:0002890)2.43600206
64Hypoplastic labia majora (HP:0000059)2.40514848
65Restlessness (HP:0000711)2.39641277
66Macroorchidism (HP:0000053)2.36156887
67Abnormal number of erythroid precursors (HP:0012131)2.32939164
68Shoulder girdle muscle weakness (HP:0003547)2.32244907
69Posterior subcapsular cataract (HP:0007787)2.31211213
70Cone-rod dystrophy (HP:0000548)2.30481677
71Retinal dysplasia (HP:0007973)2.27582456
72Astrocytoma (HP:0009592)2.27405311
73Abnormality of the astrocytes (HP:0100707)2.27405311
74Hyperphosphatemia (HP:0002905)2.27265285
75Oligodactyly (HP:0012165)2.26627137
76Short palpebral fissure (HP:0012745)2.24788070
77Renal dysplasia (HP:0000110)2.23284887
78Abnormality of calcium-phosphate metabolism (HP:0100530)2.20563612
79Hypercortisolism (HP:0001578)2.20561239
80Neoplasm of the adrenal cortex (HP:0100641)2.17796533
81Abnormal hair whorl (HP:0010721)2.13816055
82Abolished electroretinogram (ERG) (HP:0000550)2.13098211
83Labial hypoplasia (HP:0000066)2.12058056
84Ulnar claw (HP:0001178)2.08371283
85Colon cancer (HP:0003003)2.06391376
86Insidious onset (HP:0003587)2.03789666
87Termporal pattern (HP:0011008)2.03789666
88Rimmed vacuoles (HP:0003805)2.02667540
89Morphological abnormality of the middle ear (HP:0008609)1.98276812
90Abnormality of incisor morphology (HP:0011063)1.97889118
91Anophthalmia (HP:0000528)1.97479074
92Oral leukoplakia (HP:0002745)1.96647085
93Lip pit (HP:0100267)1.95623613
94Horizontal nystagmus (HP:0000666)1.93516370
95Anal atresia (HP:0002023)1.92059410
96Preauricular pit (HP:0004467)1.90933159
97Periauricular skin pits (HP:0100277)1.90933159
98Intellectual disability, moderate (HP:0002342)1.90141386
99Degeneration of anterior horn cells (HP:0002398)1.89235343
100Abnormality of the anterior horn cell (HP:0006802)1.89235343
101High anterior hairline (HP:0009890)1.88934287
102Subcapsular cataract (HP:0000523)1.88518598
103Abnormality of the phalanges of the hallux (HP:0010057)1.88328893
104Ventricular fibrillation (HP:0001663)1.86230645
105Impaired vibration sensation in the lower limbs (HP:0002166)1.86076349
106Hyperpituitarism (HP:0010514)1.86076184
107Urinary urgency (HP:0000012)1.86027161
108Medulloblastoma (HP:0002885)1.85086158
109Type II diabetes mellitus (HP:0005978)1.83544388
110Birth length less than 3rd percentile (HP:0003561)1.82492541
111Hypoplastic female external genitalia (HP:0012815)1.82279146
112Pelvic girdle muscle weakness (HP:0003749)1.81924439
113Photophobia (HP:0000613)1.81385564
114Type II lissencephaly (HP:0007260)1.80743735
115Recurrent bacterial skin infections (HP:0005406)1.80491189
116Vitreoretinal degeneration (HP:0000655)1.79955452
117Reticulocytopenia (HP:0001896)1.75209893
118Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.74636081
119Short 1st metacarpal (HP:0010034)1.74636081
120Attenuation of retinal blood vessels (HP:0007843)1.74479130
121Postnatal microcephaly (HP:0005484)1.74317453
122Vesicoureteral reflux (HP:0000076)1.73912166
123Embryonal neoplasm (HP:0002898)1.72869344
124Hyperparathyroidism (HP:0000843)1.72216084
125Flattened epiphyses (HP:0003071)1.70998127
1262-3 toe syndactyly (HP:0004691)1.70325982
127Abnormality of the 1st metacarpal (HP:0010009)1.70242144
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.69719977
129Aplasia/Hypoplasia of the sternum (HP:0006714)1.69602825
130Absence seizures (HP:0002121)1.69596036
131Renal hypoplasia (HP:0000089)1.69165139
132Abnormality of the nasal septum (HP:0000419)1.68934170
133Oligodactyly (hands) (HP:0001180)1.68706137
134Midline defect of the nose (HP:0004122)1.67905087
135Abnormality of the hip-girdle musculature (HP:0001445)1.67845503
136Abnormality of the musculature of the pelvis (HP:0001469)1.67845503
137Hepatocellular carcinoma (HP:0001402)1.67726426
138Wide nasal bridge (HP:0000431)1.67008675
139* Abnormality of the septum pellucidum (HP:0007375)1.66083570
140Depression (HP:0000716)1.65717194
141Stenosis of the external auditory canal (HP:0000402)1.64077586
142Supernumerary spleens (HP:0009799)1.63486656
143Subacute progressive viral hepatitis (HP:0006572)1.63427611
144Chronic hepatic failure (HP:0100626)1.62740869
145Short phalanx of the thumb (HP:0009660)1.62550974
146Incomplete penetrance (HP:0003829)1.62051615
147Anterior segment dysgenesis (HP:0007700)1.60302968
148Urinary bladder sphincter dysfunction (HP:0002839)1.58317158
149Truncal ataxia (HP:0002078)1.58055852
150Enlarged epiphyses (HP:0010580)1.57861404
151Fetal akinesia sequence (HP:0001989)1.57731487
152Skin pits (HP:0100276)1.57174843
153Myokymia (HP:0002411)1.56986389
154Abnormal auditory evoked potentials (HP:0006958)1.55995638
155Long eyelashes (HP:0000527)1.55195612
156Striae distensae (HP:0001065)1.53086724
157Abnormality of the corticospinal tract (HP:0002492)1.52756572
158Deep palmar crease (HP:0006191)1.52550305
159Delusions (HP:0000746)1.52024404
160* Absent septum pellucidum (HP:0001331)1.51061966
161Sandal gap (HP:0001852)1.48855814
162Facial asymmetry (HP:0000324)1.47842791
163Poor suck (HP:0002033)1.47658909
164Broad distal phalanx of finger (HP:0009836)1.47497178
165CNS hypomyelination (HP:0003429)1.47488330
166Thickened calvaria (HP:0002684)1.45545432
167Personality changes (HP:0000751)1.43657995
168Degeneration of the lateral corticospinal tracts (HP:0002314)1.41233174
169Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.41233174
170Goiter (HP:0000853)1.40541781
171Nephronophthisis (HP:0000090)1.36240845
172Sclerocornea (HP:0000647)1.36070516
173Broad face (HP:0000283)1.35218538
17411 pairs of ribs (HP:0000878)1.33793680
175Poikiloderma (HP:0001029)1.33493383
176Retinitis pigmentosa (HP:0000510)1.31377677
177Optic atrophy (HP:0000648)1.30259423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.28012040
2CDC74.74095034
3MARK14.68568464
4ICK4.43185728
5ZAK4.13601438
6MKNK13.89881923
7NEK12.78258047
8SRPK12.50733604
9ERBB32.29527058
10AKT32.20351179
11PNCK2.20281866
12EIF2AK22.05836826
13PASK1.96485528
14DYRK31.93887536
15SGK4941.90417862
16SGK2231.90417862
17PLK21.75294194
18CSNK1G31.73382626
19CLK11.73154361
20PLK31.64247006
21CSNK1A1L1.62888047
22CASK1.62704443
23NTRK21.62561516
24EPHA41.62161726
25BMX1.58660611
26TNK21.58001939
27TAOK11.57400173
28SGK21.56819181
29MINK11.52284339
30DYRK21.51767985
31MKNK21.48956582
32TSSK61.46790354
33MAP2K71.37662598
34TLK11.35156278
35TTK1.34947302
36LIMK11.34349733
37TAF11.30058166
38CSNK1G21.25478403
39PHKG11.25142332
40PHKG21.25142332
41CAMK1G1.24414402
42PAK31.23884158
43BRD41.23879998
44EPHB21.23538890
45ALK1.22307208
46CAMKK21.21506132
47EIF2AK11.21289333
48ATR1.15402130
49DYRK1A1.15120482
50MTOR1.14694104
51MAPK151.14458682
52CSNK1E1.10798751
53PRKCG1.10536892
54LMTK21.08791433
55NTRK31.06730075
56GRK71.06481582
57VRK11.05339392
58FER1.02853999
59CAMK1D1.01770096
60BCR1.00938343
61PRKAA11.00933488
62CHEK11.00207723
63DYRK1B0.99120453
64BRAF0.98415071
65CAMKK10.97561778
66PIM20.93937967
67MAP3K60.90189192
68ERBB20.88685284
69ACVR1B0.88164301
70CSNK1G10.87643086
71DAPK10.87349104
72DAPK20.85491883
73SGK30.83692516
74TESK20.82540190
75ROCK20.82430406
76PAK40.82286342
77PLK10.81874747
78MAP4K20.80067242
79IRAK20.78159251
80PRKCE0.77747737
81ILK0.76229475
82CDK30.75715836
83CDK20.74693020
84MAPK130.73496935
85CSNK2A20.73138624
86MAPK90.73089520
87PRKCZ0.72979215
88AURKA0.72595031
89ADRBK10.72075722
90PIM10.71381901
91DDR20.71223765
92MARK20.70266218
93PIK3CA0.70158735
94TYK20.69675520
95PKN10.69361644
96CDK10.67692480
97TGFBR10.67280840
98PLK40.66201875
99PRKCB0.66008763
100PRKD30.63973168
101EIF2AK30.63915789
102GRK10.63532629
103TESK10.63244751
104PRKCI0.62774774
105MAPK80.61825006
106BUB10.61429648
107CDK140.60845493
108MAP3K40.60624132
109CDK50.60424183
110GSK3B0.59812183
111PRKDC0.59797733
112YES10.57782250
113KDR0.56717092
114BRSK20.55886353
115CHEK20.55508658
116AKT10.55274768
117PAK60.54899476
118RPS6KA50.54533087
119RPS6KA30.53780305
120FES0.53615582
121CAMK40.53405361
122RPS6KB10.52291936
123CSNK1D0.52221073
124MELK0.51223960
125SIK20.50863893
126MAPK100.50339014
127CDK180.49910943
128FGFR10.49907547
129STK40.49778578
130CDK150.49610790
131WEE10.49205979
132MAPK140.49006710
133SGK10.48655750
134ATM0.48464553
135CDK70.48062912
136AURKB0.48054209
137PRKACB0.46785073
138PBK0.46646946
139WNK30.45081093
140RPS6KA60.44866797
141RPS6KC10.44174913
142RPS6KL10.44174913
143CDK11A0.42960565
144MAP3K100.42722724
145LRRK20.42705215
146RPS6KA20.42002666
147MARK30.40902509
148STK110.40854189
149CSNK1A10.40291042
150WNK40.40191192
151BRSK10.35922251
152IRAK40.35396340

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.08701462
2Nicotine addiction_Homo sapiens_hsa050334.03349305
3Ribosome_Homo sapiens_hsa030103.63850863
4Synaptic vesicle cycle_Homo sapiens_hsa047213.37385647
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.82311376
6Cholinergic synapse_Homo sapiens_hsa047252.71043985
7Oxidative phosphorylation_Homo sapiens_hsa001902.62820474
8Spliceosome_Homo sapiens_hsa030402.59414996
9GABAergic synapse_Homo sapiens_hsa047272.53865592
10Parkinsons disease_Homo sapiens_hsa050122.31902429
11Mismatch repair_Homo sapiens_hsa034302.29616078
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.23261971
13Morphine addiction_Homo sapiens_hsa050322.07986510
14Alzheimers disease_Homo sapiens_hsa050101.97397377
15Basal transcription factors_Homo sapiens_hsa030221.90391149
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.87897147
17Cocaine addiction_Homo sapiens_hsa050301.85259402
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84399178
19Circadian entrainment_Homo sapiens_hsa047131.82643872
20RNA polymerase_Homo sapiens_hsa030201.81138627
21DNA replication_Homo sapiens_hsa030301.79064526
22Huntingtons disease_Homo sapiens_hsa050161.69930988
23Axon guidance_Homo sapiens_hsa043601.68299538
24Proteasome_Homo sapiens_hsa030501.66027084
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.57684415
26Insulin secretion_Homo sapiens_hsa049111.52091258
27Fatty acid biosynthesis_Homo sapiens_hsa000611.46888731
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45794037
29Cell cycle_Homo sapiens_hsa041101.44542233
30Lysine degradation_Homo sapiens_hsa003101.42942821
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40272050
32Notch signaling pathway_Homo sapiens_hsa043301.34853895
33Oocyte meiosis_Homo sapiens_hsa041141.31353893
34mRNA surveillance pathway_Homo sapiens_hsa030151.30188421
35Circadian rhythm_Homo sapiens_hsa047101.26869129
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25607028
37Vibrio cholerae infection_Homo sapiens_hsa051101.25443353
38Olfactory transduction_Homo sapiens_hsa047401.25393424
39Glutamatergic synapse_Homo sapiens_hsa047241.22161006
40Non-small cell lung cancer_Homo sapiens_hsa052231.21176052
41Protein export_Homo sapiens_hsa030601.16906819
42Dopaminergic synapse_Homo sapiens_hsa047281.15658107
43Hedgehog signaling pathway_Homo sapiens_hsa043401.14862576
44Sulfur relay system_Homo sapiens_hsa041221.14734686
45Pyruvate metabolism_Homo sapiens_hsa006201.13124372
46Endometrial cancer_Homo sapiens_hsa052131.11923480
47Basal cell carcinoma_Homo sapiens_hsa052171.11664728
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11288502
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11253239
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09038667
51Homologous recombination_Homo sapiens_hsa034401.08286194
52Inositol phosphate metabolism_Homo sapiens_hsa005621.05953352
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05713553
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05682620
55Ovarian steroidogenesis_Homo sapiens_hsa049131.05452384
56Steroid biosynthesis_Homo sapiens_hsa001001.04187307
57Retinol metabolism_Homo sapiens_hsa008301.02019306
58RNA transport_Homo sapiens_hsa030130.99627616
59Thyroid cancer_Homo sapiens_hsa052160.99360610
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95442601
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93638623
62Biosynthesis of amino acids_Homo sapiens_hsa012300.93568474
63Butanoate metabolism_Homo sapiens_hsa006500.93414134
64Folate biosynthesis_Homo sapiens_hsa007900.92790522
65Wnt signaling pathway_Homo sapiens_hsa043100.91494432
66Pyrimidine metabolism_Homo sapiens_hsa002400.91468080
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91106926
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90614553
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88439656
70Dilated cardiomyopathy_Homo sapiens_hsa054140.87939087
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86626733
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.85936976
73Adherens junction_Homo sapiens_hsa045200.83692908
74Renin secretion_Homo sapiens_hsa049240.82501629
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82493016
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82240876
77Colorectal cancer_Homo sapiens_hsa052100.81809008
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80481307
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78447270
80Salivary secretion_Homo sapiens_hsa049700.77865342
81Long-term potentiation_Homo sapiens_hsa047200.77136015
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73863204
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.72698601
84Glucagon signaling pathway_Homo sapiens_hsa049220.72440402
85RNA degradation_Homo sapiens_hsa030180.71260665
86Oxytocin signaling pathway_Homo sapiens_hsa049210.70312423
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70176560
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69076916
89Arginine and proline metabolism_Homo sapiens_hsa003300.68885676
90p53 signaling pathway_Homo sapiens_hsa041150.68246587
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68203590
92Bile secretion_Homo sapiens_hsa049760.67741095
93Estrogen signaling pathway_Homo sapiens_hsa049150.66324442
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66271918
95Hippo signaling pathway_Homo sapiens_hsa043900.66176180
96Serotonergic synapse_Homo sapiens_hsa047260.65839514
97Long-term depression_Homo sapiens_hsa047300.65022305
98Purine metabolism_Homo sapiens_hsa002300.64525719
99Systemic lupus erythematosus_Homo sapiens_hsa053220.63036185
100Prion diseases_Homo sapiens_hsa050200.62969077
101Melanogenesis_Homo sapiens_hsa049160.62964694
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62567065
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58170529
104Calcium signaling pathway_Homo sapiens_hsa040200.57955803
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55797050
106Fatty acid degradation_Homo sapiens_hsa000710.55771324
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.54245966
108Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54125793
109Fanconi anemia pathway_Homo sapiens_hsa034600.52622819
110MicroRNAs in cancer_Homo sapiens_hsa052060.52317261
111Carbon metabolism_Homo sapiens_hsa012000.51550842
112Small cell lung cancer_Homo sapiens_hsa052220.51432372
113Alcoholism_Homo sapiens_hsa050340.50791600
114One carbon pool by folate_Homo sapiens_hsa006700.50704112
115FoxO signaling pathway_Homo sapiens_hsa040680.50093630
116Cardiac muscle contraction_Homo sapiens_hsa042600.50004999
117GnRH signaling pathway_Homo sapiens_hsa049120.49754422
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49752296
119Base excision repair_Homo sapiens_hsa034100.48871073
120Taste transduction_Homo sapiens_hsa047420.47887649
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45459893
122Thyroid hormone synthesis_Homo sapiens_hsa049180.44191842
123Gap junction_Homo sapiens_hsa045400.43588009
124Vitamin B6 metabolism_Homo sapiens_hsa007500.42204518
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41990793
126Amphetamine addiction_Homo sapiens_hsa050310.40562007
127Tight junction_Homo sapiens_hsa045300.40204342
128Gastric acid secretion_Homo sapiens_hsa049710.40147023
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39122291
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38907829
131ErbB signaling pathway_Homo sapiens_hsa040120.38803520
132Tyrosine metabolism_Homo sapiens_hsa003500.38470779
133Type II diabetes mellitus_Homo sapiens_hsa049300.37981696
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.36699278
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36583155
136Pancreatic secretion_Homo sapiens_hsa049720.34478660
137Choline metabolism in cancer_Homo sapiens_hsa052310.34443360
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34124104
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25737892
140Insulin signaling pathway_Homo sapiens_hsa049100.24708635
141Nucleotide excision repair_Homo sapiens_hsa034200.24677833
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24132408

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