LHX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sensory perception of smell (GO:0007608)6.14501902
2cerebral cortex neuron differentiation (GO:0021895)5.67118108
3cell proliferation in forebrain (GO:0021846)5.30297487
4behavioral response to nicotine (GO:0035095)5.22896668
5layer formation in cerebral cortex (GO:0021819)5.16866092
6negative regulation of astrocyte differentiation (GO:0048712)5.09212435
7substrate-independent telencephalic tangential migration (GO:0021826)5.06217566
8substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.06217566
9* olfactory bulb development (GO:0021772)4.92845664
10regulation of chromatin binding (GO:0035561)4.68061397
11presynaptic membrane organization (GO:0097090)4.56237774
12neuron cell-cell adhesion (GO:0007158)4.29183728
13negative regulation of oligodendrocyte differentiation (GO:0048715)4.26173139
14cerebral cortex radially oriented cell migration (GO:0021799)4.24929588
15dendritic spine morphogenesis (GO:0060997)4.22319358
16central nervous system projection neuron axonogenesis (GO:0021952)4.21592551
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.20254995
18locomotory exploration behavior (GO:0035641)4.18873817
19axonal fasciculation (GO:0007413)4.18100003
20cell migration in hindbrain (GO:0021535)4.12852119
21synaptic vesicle maturation (GO:0016188)4.11219295
22establishment of mitochondrion localization (GO:0051654)4.10989566
23neuron recognition (GO:0008038)4.06406055
24protein localization to synapse (GO:0035418)4.01064066
25transmission of nerve impulse (GO:0019226)3.95609146
26positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.90147193
27mitochondrion transport along microtubule (GO:0047497)3.87196796
28establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.87196796
29dendrite morphogenesis (GO:0048813)3.85043384
30glutamate secretion (GO:0014047)3.83668047
31lateral sprouting from an epithelium (GO:0060601)3.83526081
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.78441743
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.72329862
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71609143
35hippocampus development (GO:0021766)3.70358744
36vocalization behavior (GO:0071625)3.67796440
37regulation of glutamate receptor signaling pathway (GO:1900449)3.67408635
38tongue development (GO:0043586)3.66110172
39regulation of short-term neuronal synaptic plasticity (GO:0048172)3.64773535
40protein localization to cilium (GO:0061512)3.61030785
41mechanosensory behavior (GO:0007638)3.60848531
42synaptic vesicle exocytosis (GO:0016079)3.59193636
43sensory perception of chemical stimulus (GO:0007606)3.56970099
44retinal ganglion cell axon guidance (GO:0031290)3.56933216
45negative regulation of glial cell differentiation (GO:0045686)3.54345000
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.52532201
47forebrain neuron differentiation (GO:0021879)3.50212459
48postsynaptic membrane organization (GO:0001941)3.49341704
49central nervous system neuron axonogenesis (GO:0021955)3.46918377
50regulation of synapse structural plasticity (GO:0051823)3.41479463
51behavioral response to cocaine (GO:0048148)3.40174523
52ephrin receptor signaling pathway (GO:0048013)3.39120273
53neuronal ion channel clustering (GO:0045161)3.39105612
54regulation of female receptivity (GO:0045924)3.37427276
55regulation of oligodendrocyte differentiation (GO:0048713)3.37250982
56L-amino acid import (GO:0043092)3.36845505
57neuron fate determination (GO:0048664)3.35220800
58spinal cord association neuron differentiation (GO:0021527)3.34640078
59positive regulation of oligodendrocyte differentiation (GO:0048714)3.32200184
60protein polyglutamylation (GO:0018095)3.31851239
61pyrimidine nucleobase catabolic process (GO:0006208)3.29760582
62short-term memory (GO:0007614)3.29735284
63exploration behavior (GO:0035640)3.28838871
64adult walking behavior (GO:0007628)3.27442017
65cranial nerve morphogenesis (GO:0021602)3.26627755
66neurotransmitter-gated ion channel clustering (GO:0072578)3.25182770
67forebrain cell migration (GO:0021885)3.18013815
68nonmotile primary cilium assembly (GO:0035058)3.16259462
69regulation of astrocyte differentiation (GO:0048710)3.15572686
70neuroblast proliferation (GO:0007405)3.13213607
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13004127
72positive regulation of synapse assembly (GO:0051965)3.12576056
73ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.11787839
74regulation of neuronal synaptic plasticity (GO:0048168)3.11591225
75dendrite development (GO:0016358)3.11014751
76ovulation cycle (GO:0042698)3.10226576
77ionotropic glutamate receptor signaling pathway (GO:0035235)3.08340193
78glial cell proliferation (GO:0014009)3.08076810
79spinal cord development (GO:0021510)3.07629612
80central nervous system myelination (GO:0022010)3.07441709
81axon ensheathment in central nervous system (GO:0032291)3.07441709
82glutamate receptor signaling pathway (GO:0007215)3.06006378
83intraciliary transport (GO:0042073)3.05037693
84regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03582533
85planar cell polarity pathway involved in neural tube closure (GO:0090179)3.02139064
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.01515448
87somite development (GO:0061053)3.01334810
88camera-type eye morphogenesis (GO:0048593)3.00092372
89positive regulation of neuroblast proliferation (GO:0002052)2.98477057
90cerebral cortex cell migration (GO:0021795)2.98056599
91ganglion development (GO:0061548)2.97072219
92regulation of microtubule-based movement (GO:0060632)2.96046950
93cerebellar Purkinje cell differentiation (GO:0021702)2.95125510
94epithelial cilium movement (GO:0003351)2.94554057
95axonemal dynein complex assembly (GO:0070286)2.94008753
96synaptic vesicle endocytosis (GO:0048488)2.93516593
97microtubule severing (GO:0051013)2.93242908
98positive regulation of dendritic spine morphogenesis (GO:0061003)2.93186340
99negative regulation of gliogenesis (GO:0014014)2.92547543
100female mating behavior (GO:0060180)2.91841133
101* axon extension (GO:0048675)2.91214882
102G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.90529424
103presynaptic membrane assembly (GO:0097105)2.90404046
104neuromuscular synaptic transmission (GO:0007274)2.90008795
105limb bud formation (GO:0060174)2.89713923
106regulation of synaptic vesicle exocytosis (GO:2000300)2.89088165
107positive regulation of synapse maturation (GO:0090129)2.88889611
108specification of organ identity (GO:0010092)2.88145471
109regulation of cilium movement (GO:0003352)2.86924257
110telencephalon cell migration (GO:0022029)2.85490771
111regulation of dendritic spine morphogenesis (GO:0061001)2.84823194
112behavioral fear response (GO:0001662)2.84821208
113behavioral defense response (GO:0002209)2.84821208
114synaptic transmission, cholinergic (GO:0007271)2.84318448
115adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.82147885
116negative regulation of microtubule polymerization (GO:0031115)2.82147848
117regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.82076566
118regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.81744560
119protein insertion into membrane (GO:0051205)2.81104734
120calcium-mediated signaling using intracellular calcium source (GO:0035584)2.80345346
121dendritic spine organization (GO:0097061)2.79756504
122synaptic transmission, glutamatergic (GO:0035249)2.78078893
123axon extension involved in axon guidance (GO:0048846)2.75349427
124neuron projection extension involved in neuron projection guidance (GO:1902284)2.75349427
125auditory behavior (GO:0031223)2.73929361
126dentate gyrus development (GO:0021542)2.71161030
127cilium movement (GO:0003341)2.71144549
128cellular potassium ion homeostasis (GO:0030007)2.71068596
129keratinocyte development (GO:0003334)2.70674908
130amino acid import (GO:0043090)2.70403496
131social behavior (GO:0035176)2.69875673
132intraspecies interaction between organisms (GO:0051703)2.69875673
133neurotransmitter secretion (GO:0007269)2.68353365
134response to auditory stimulus (GO:0010996)2.67633211
135positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.67252928
136long-term synaptic potentiation (GO:0060291)2.66837717
137positive regulation of dendritic spine development (GO:0060999)2.66789660
138neuron migration (GO:0001764)2.66505002
139regulation of synaptic plasticity (GO:0048167)2.63935456
140negative regulation of response to food (GO:0032096)2.63056774
141negative regulation of appetite (GO:0032099)2.63056774
142axonogenesis (GO:0007409)2.62777922
143fear response (GO:0042596)2.62184932
144proline transport (GO:0015824)2.59710483
145brain morphogenesis (GO:0048854)2.56873586
146microtubule bundle formation (GO:0001578)2.56572730
147synapse assembly (GO:0007416)2.56529638
148negative regulation of catenin import into nucleus (GO:0035414)2.56030170
149nucleobase catabolic process (GO:0046113)2.55691349
150cerebellar granule cell differentiation (GO:0021707)2.55538353
151mating behavior (GO:0007617)2.55365005
152response to pheromone (GO:0019236)2.54795375
153* neuron projection extension (GO:1990138)2.54777746
154appendage development (GO:0048736)2.53552156
155limb development (GO:0060173)2.53552156
156membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.53338687
157neuron projection morphogenesis (GO:0048812)2.52326103
158positive regulation of neural precursor cell proliferation (GO:2000179)2.50903503
159prepulse inhibition (GO:0060134)2.50822571

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.33959240
2* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.19218261
3* RNF2_18974828_ChIP-Seq_MESCs_Mouse3.02443946
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse3.02443946
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.91876521
6* EZH2_27304074_Chip-Seq_ESCs_Mouse2.83193226
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.79776201
8* EED_16625203_ChIP-ChIP_MESCs_Mouse2.77519473
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76798291
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74133477
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69483193
12* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.67940599
13* RNF2_27304074_Chip-Seq_ESCs_Mouse2.62742407
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53967786
15* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.49203711
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47550833
17* EZH2_27294783_Chip-Seq_ESCs_Mouse2.42548783
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28030779
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27737461
20* CBX2_27304074_Chip-Seq_ESCs_Mouse2.21345705
21* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.12953772
22* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.09372270
23* RING1B_27294783_Chip-Seq_ESCs_Mouse2.07248170
24GBX2_23144817_ChIP-Seq_PC3_Human2.00214974
25DROSHA_22980978_ChIP-Seq_HELA_Human1.92152140
26* RING1B_27294783_Chip-Seq_NPCs_Mouse1.88876194
27* REST_21632747_ChIP-Seq_MESCs_Mouse1.88394051
28TAF15_26573619_Chip-Seq_HEK293_Human1.79276911
29RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.78558310
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73072820
31AR_21572438_ChIP-Seq_LNCaP_Human1.71732878
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.70205005
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.65724681
34* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64052593
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.60759570
36IGF1R_20145208_ChIP-Seq_DFB_Human1.59712017
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59241973
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.58560395
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54914692
40ZNF274_21170338_ChIP-Seq_K562_Hela1.50709409
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44288576
42* RNF2_27304074_Chip-Seq_NSC_Mouse1.42323941
43* TP53_20018659_ChIP-ChIP_R1E_Mouse1.40681155
44IRF1_19129219_ChIP-ChIP_H3396_Human1.40464712
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.38648575
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37941421
47* ERG_21242973_ChIP-ChIP_JURKAT_Human1.37665952
48* REST_18959480_ChIP-ChIP_MESCs_Mouse1.36637007
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32822728
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26711607
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26103941
52* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23970719
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23820321
54AHR_22903824_ChIP-Seq_MCF-7_Human1.23100739
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23073002
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22346908
57* KDM2B_26808549_Chip-Seq_K562_Human1.22220550
58TP53_18474530_ChIP-ChIP_U2OS_Human1.22162165
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.21968605
60* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21585015
61VDR_22108803_ChIP-Seq_LS180_Human1.21459192
62* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20626110
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20343380
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19562198
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14885389
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14885389
67KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13830207
68E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13683013
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.11775450
70P300_19829295_ChIP-Seq_ESCs_Human1.11772476
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10919317
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10806383
73ARNT_22903824_ChIP-Seq_MCF-7_Human1.10459062
74WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10448323
75SMAD4_21799915_ChIP-Seq_A2780_Human1.10182084
76P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09866912
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09017397
78* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08790326
79* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07997584
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07965798
81* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06897202
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06644538
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04396111
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03370508
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03322900
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02818364
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01944469
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.01570916
89FUS_26573619_Chip-Seq_HEK293_Human1.00269595
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98975368
91NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98041344
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97145496
93SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96376801
94* SOX2_21211035_ChIP-Seq_LN229_Gbm0.95469336
95AR_19668381_ChIP-Seq_PC3_Human0.95358089
96* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95039656
97WDR5_24793694_ChIP-Seq_LNCAP_Human0.95028113
98* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93847698
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.93647704
100BCAT_22108803_ChIP-Seq_LS180_Human0.92839255
101FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92225406
102* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91586068
103AR_25329375_ChIP-Seq_VCAP_Human0.91106770
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90989008
105ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90702327
106SMAD4_21741376_ChIP-Seq_HESCs_Human0.90695753
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.90077215
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.89715415
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88222607
110PRDM14_20953172_ChIP-Seq_ESCs_Human0.88211146
111WT1_19549856_ChIP-ChIP_CCG9911_Human0.87041708
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.87023700
113* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86686336
114NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85663282
115ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84292852
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.84221411
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.84175127
118DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83641513
119LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83043359
120SOX9_26525672_Chip-Seq_HEART_Mouse0.82807487
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.82787904
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.82770373
123CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.82654269
124CTCF_27219007_Chip-Seq_Bcells_Human0.82436543
125KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82316875
126RUNX2_22187159_ChIP-Seq_PCA_Human0.81897343
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81787674
128SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81316988
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80827213
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.80370136
131* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80055006

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008789_abnormal_olfactory_epithelium5.57009345
2MP0005394_taste/olfaction_phenotype5.18176448
3MP0005499_abnormal_olfactory_system5.18176448
4MP0001984_abnormal_olfaction4.22140559
5MP0004859_abnormal_synaptic_plasticity3.93062095
6MP0000778_abnormal_nervous_system3.17437429
7MP0005645_abnormal_hypothalamus_physiol2.59846221
8MP0003122_maternal_imprinting2.55775394
9MP0002102_abnormal_ear_morphology2.51869185
10MP0003123_paternal_imprinting2.50323866
11MP0003880_abnormal_central_pattern2.46595895
12MP0003635_abnormal_synaptic_transmissio2.45010442
13MP0009379_abnormal_foot_pigmentation2.41251670
14MP0004270_analgesia2.27339599
15MP0003121_genomic_imprinting2.27052685
16MP0002184_abnormal_innervation2.23676726
17MP0000049_abnormal_middle_ear2.16904497
18MP0002063_abnormal_learning/memory/cond2.13627210
19MP0004858_abnormal_nervous_system2.02299921
20MP0002249_abnormal_larynx_morphology1.98537738
21MP0002233_abnormal_nose_morphology1.96490161
22MP0001486_abnormal_startle_reflex1.96333608
23MP0003787_abnormal_imprinting1.92269574
24MP0006292_abnormal_olfactory_placode1.85601156
25MP0005187_abnormal_penis_morphology1.68307493
26MP0009745_abnormal_behavioral_response1.66454707
27MP0002557_abnormal_social/conspecific_i1.64618821
28MP0004885_abnormal_endolymph1.63550552
29* MP0002882_abnormal_neuron_morphology1.59252589
30MP0002822_catalepsy1.59135852
31MP0002572_abnormal_emotion/affect_behav1.57411438
32MP0008877_abnormal_DNA_methylation1.53998169
33MP0002064_seizures1.52563521
34MP0000537_abnormal_urethra_morphology1.52457103
35MP0001485_abnormal_pinna_reflex1.52369508
36MP0001529_abnormal_vocalization1.51127682
37MP0002734_abnormal_mechanical_nocicepti1.50269280
38MP0010234_abnormal_vibrissa_follicle1.49496275
39MP0009780_abnormal_chondrocyte_physiolo1.48150120
40MP0004142_abnormal_muscle_tone1.45834529
41MP0004811_abnormal_neuron_physiology1.45694481
42MP0003890_abnormal_embryonic-extraembry1.45005585
43MP0002653_abnormal_ependyma_morphology1.41152297
44MP0010030_abnormal_orbit_morphology1.38528959
45MP0005423_abnormal_somatic_nervous1.38173189
46MP0002638_abnormal_pupillary_reflex1.36214054
47* MP0002152_abnormal_brain_morphology1.35921037
48* MP0002752_abnormal_somatic_nervous1.35060103
49MP0000631_abnormal_neuroendocrine_gland1.35054247
50MP0005646_abnormal_pituitary_gland1.33076092
51* MP0003861_abnormal_nervous_system1.31317310
52MP0005623_abnormal_meninges_morphology1.29967088
53MP0000647_abnormal_sebaceous_gland1.27832924
54MP0004133_heterotaxia1.26751834
55MP0002272_abnormal_nervous_system1.24463216
56MP0002163_abnormal_gland_morphology1.23453571
57MP0002234_abnormal_pharynx_morphology1.21627984
58MP0005248_abnormal_Harderian_gland1.21604398
59MP0009250_abnormal_appendicular_skeleto1.20264999
60* MP0000955_abnormal_spinal_cord1.17758475
61MP0008569_lethality_at_weaning1.16753666
62MP0000579_abnormal_nail_morphology1.16393372
63MP0003938_abnormal_ear_development1.16193988
64MP0002938_white_spotting1.15499906
65MP0003755_abnormal_palate_morphology1.15444017
66MP0001968_abnormal_touch/_nociception1.15241655
67MP0000026_abnormal_inner_ear1.13579035
68MP0002067_abnormal_sensory_capabilities1.12310841
69MP0004145_abnormal_muscle_electrophysio1.11376124
70MP0009053_abnormal_anal_canal1.11346662
71MP0009046_muscle_twitch1.07940505
72MP0003879_abnormal_hair_cell1.06817382
73MP0003942_abnormal_urinary_system1.01249197
74MP0000678_abnormal_parathyroid_gland1.00688585
75* MP0001293_anophthalmia1.00307722
76MP0002282_abnormal_trachea_morphology0.97744488
77MP0003705_abnormal_hypodermis_morpholog0.97716893
78MP0000762_abnormal_tongue_morphology0.92473527
79MP0005386_behavior/neurological_phenoty0.92420003
80MP0004924_abnormal_behavior0.92420003
81MP0000566_synostosis0.92268153
82MP0002116_abnormal_craniofacial_bone0.91760213
83MP0001905_abnormal_dopamine_level0.89783650
84MP0001346_abnormal_lacrimal_gland0.89525940
85MP0001340_abnormal_eyelid_morphology0.89416660
86MP0003315_abnormal_perineum_morphology0.88707653
87MP0003329_amyloid_beta_deposits0.88260475
88MP0002098_abnormal_vibrissa_morphology0.88255337
89MP0003646_muscle_fatigue0.88139318
90MP0006276_abnormal_autonomic_nervous0.87903663
91MP0005551_abnormal_eye_electrophysiolog0.87771560
92MP0003878_abnormal_ear_physiology0.87514502
93MP0005377_hearing/vestibular/ear_phenot0.87514502
94MP0005367_renal/urinary_system_phenotyp0.86018305
95MP0000516_abnormal_urinary_system0.86018305
96MP0003634_abnormal_glial_cell0.85724053
97MP0002160_abnormal_reproductive_system0.84763333
98MP0006072_abnormal_retinal_apoptosis0.84128317
99MP0003136_yellow_coat_color0.83838762
100* MP0002081_perinatal_lethality0.83791416
101MP0000534_abnormal_ureter_morphology0.82681988
102MP0000428_abnormal_craniofacial_morphol0.82667749
103MP0005253_abnormal_eye_physiology0.80102269
104MP0001502_abnormal_circadian_rhythm0.79197054
105MP0002736_abnormal_nociception_after0.78761864
106MP0002896_abnormal_bone_mineralization0.78512925
107MP0001849_ear_inflammation0.77732291
108MP0001919_abnormal_reproductive_system0.77430403
109* MP0001286_abnormal_eye_development0.77399297
110MP0002066_abnormal_motor_capabilities/c0.76306893
111MP0003385_abnormal_body_wall0.74633173
112MP0001440_abnormal_grooming_behavior0.74612098
113MP0002229_neurodegeneration0.74570628
114MP0001299_abnormal_eye_distance/0.73767571
115MP0002735_abnormal_chemical_nociception0.73534420
116MP0002177_abnormal_outer_ear0.73366732
117MP0002009_preneoplasia0.72446289
118MP0002733_abnormal_thermal_nociception0.71906611
119MP0001970_abnormal_pain_threshold0.71808479
120MP0001963_abnormal_hearing_physiology0.71347525
121MP0003119_abnormal_digestive_system0.70280304
122* MP0005391_vision/eye_phenotype0.70223747
123MP0004742_abnormal_vestibular_system0.70037923
124MP0001501_abnormal_sleep_pattern0.69145919
125MP0010678_abnormal_skin_adnexa0.68539755
126MP0003935_abnormal_craniofacial_develop0.67759025
127MP0005379_endocrine/exocrine_gland_phen0.67684450
128MP0001188_hyperpigmentation0.67278463
129MP0003937_abnormal_limbs/digits/tail_de0.67246720
130MP0005389_reproductive_system_phenotype0.67218291
131* MP0005195_abnormal_posterior_eye0.66693152
132MP0003011_delayed_dark_adaptation0.65413591
133MP0003633_abnormal_nervous_system0.64347847

Predicted human phenotypes

RankGene SetZ-score
1Anosmia (HP:0000458)4.74333919
2Focal motor seizures (HP:0011153)4.11169093
3Fragile nails (HP:0001808)3.75232324
4Megalencephaly (HP:0001355)3.71692454
5Myokymia (HP:0002411)3.45644065
6Rib fusion (HP:0000902)3.35943818
7Nephronophthisis (HP:0000090)3.32386254
8Focal seizures (HP:0007359)3.25900846
9Palpebral edema (HP:0100540)3.17308002
10Pelvic girdle muscle weakness (HP:0003749)3.06831599
11Visual hallucinations (HP:0002367)2.89963637
12Molar tooth sign on MRI (HP:0002419)2.85635286
13Abnormality of midbrain morphology (HP:0002418)2.85635286
14Pancreatic fibrosis (HP:0100732)2.83600725
15Abnormality of the musculature of the pelvis (HP:0001469)2.82013912
16Abnormality of the hip-girdle musculature (HP:0001445)2.82013912
17Obstructive sleep apnea (HP:0002870)2.80560078
18Reticulocytopenia (HP:0001896)2.78855508
19True hermaphroditism (HP:0010459)2.78646033
20Erectile abnormalities (HP:0100639)2.75901963
21Epileptic encephalopathy (HP:0200134)2.74521150
22Absence seizures (HP:0002121)2.73347107
23Abnormal respiratory motile cilium physiology (HP:0012261)2.73129793
24Aplasia involving bones of the extremities (HP:0009825)2.70865829
25Aplasia involving bones of the upper limbs (HP:0009823)2.70865829
26Aplasia of the phalanges of the hand (HP:0009802)2.70865829
27Adrenal hypoplasia (HP:0000835)2.70426917
28Febrile seizures (HP:0002373)2.69726612
29Polyphagia (HP:0002591)2.66840325
30Aplasia/Hypoplasia of the sternum (HP:0006714)2.63952046
31Down-sloping shoulders (HP:0200021)2.63593089
32Septo-optic dysplasia (HP:0100842)2.62839982
33Pachygyria (HP:0001302)2.61686881
34Abnormality of the labia minora (HP:0012880)2.61077639
35Abnormal ciliary motility (HP:0012262)2.60305362
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60079158
37Coronal craniosynostosis (HP:0004440)2.55956059
38Abnormality of the renal medulla (HP:0100957)2.52525217
39Agitation (HP:0000713)2.49038487
40Deep palmar crease (HP:0006191)2.47526601
41Abnormality of the aortic arch (HP:0012303)2.41700573
42Atonic seizures (HP:0010819)2.41645022
43Hyperventilation (HP:0002883)2.38185381
44Exotropia (HP:0000577)2.36744908
45Abnormality of the 4th metacarpal (HP:0010012)2.36650371
46Retinal dysplasia (HP:0007973)2.34943152
47Dialeptic seizures (HP:0011146)2.34860553
48Lissencephaly (HP:0001339)2.34567195
49Supranuclear gaze palsy (HP:0000605)2.31512079
50Action tremor (HP:0002345)2.28742884
51Gait imbalance (HP:0002141)2.28256788
52Abnormal eating behavior (HP:0100738)2.27542618
53Excessive salivation (HP:0003781)2.27504704
54Drooling (HP:0002307)2.27504704
55Sclerocornea (HP:0000647)2.27319014
56Inappropriate behavior (HP:0000719)2.27073384
57Aplasia/Hypoplasia of the breasts (HP:0010311)2.26739850
58Absent/shortened dynein arms (HP:0200106)2.25920645
59Dynein arm defect of respiratory motile cilia (HP:0012255)2.25920645
60Abnormality of the metopic suture (HP:0005556)2.24918503
61Bronchomalacia (HP:0002780)2.23764413
62Abnormality of the middle phalanges of the toes (HP:0010183)2.23381856
63Limb dystonia (HP:0002451)2.22161312
64Pancreatic cysts (HP:0001737)2.21817011
65Postaxial foot polydactyly (HP:0001830)2.20773488
66Genetic anticipation (HP:0003743)2.19951213
67Generalized tonic-clonic seizures (HP:0002069)2.18335060
68Oligodactyly (hands) (HP:0001180)2.18251583
69Breast aplasia (HP:0100783)2.13725544
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.13006385
71Short 4th metacarpal (HP:0010044)2.13006385
72Apathy (HP:0000741)2.12020041
73Growth hormone deficiency (HP:0000824)2.10693456
74Insomnia (HP:0100785)2.09983310
75Stereotypic behavior (HP:0000733)2.09720257
76Sex reversal (HP:0012245)2.09590844
77Abnormal sex determination (HP:0012244)2.09590844
78Mixed hearing impairment (HP:0000410)2.09568283
79Amblyopia (HP:0000646)2.09091057
80Anencephaly (HP:0002323)2.08769643
81Broad-based gait (HP:0002136)2.08628535
82Abnormality of the corticospinal tract (HP:0002492)2.07928238
83Sleep apnea (HP:0010535)2.05625255
84Hypoplasia of the brainstem (HP:0002365)2.05389165
85Aplasia/Hypoplasia of the brainstem (HP:0007362)2.05389165
86Abnormal respiratory epithelium morphology (HP:0012253)2.05264712
87Abnormal respiratory motile cilium morphology (HP:0005938)2.05264712
88Hemiparesis (HP:0001269)2.04449653
89Poor coordination (HP:0002370)2.04308326
90Vaginal atresia (HP:0000148)2.04262024
91Diastasis recti (HP:0001540)2.03862706
92Abnormality of the diencephalon (HP:0010662)2.03096799
93Genital tract atresia (HP:0001827)2.03037256
94Neoplasm of the adrenal cortex (HP:0100641)2.02386668
95Humeroradial synostosis (HP:0003041)2.02202947
96Synostosis involving the elbow (HP:0003938)2.02202947
97Ectopic kidney (HP:0000086)2.01809471
98Narrow forehead (HP:0000341)2.00114242
99Cutaneous finger syndactyly (HP:0010554)1.98610935
100Anophthalmia (HP:0000528)1.98441388
101Postaxial hand polydactyly (HP:0001162)1.98394300
102Abnormality of cells of the erythroid lineage (HP:0012130)1.98226990
103Chronic hepatic failure (HP:0100626)1.96498633
104Optic nerve hypoplasia (HP:0000609)1.93941366
105Abnormality of salivation (HP:0100755)1.93135202
106Abnormality of macular pigmentation (HP:0008002)1.93028867
107Hyperglycinemia (HP:0002154)1.91184941
108Concave nail (HP:0001598)1.90584272
109Abnormality of the antihelix (HP:0009738)1.90252710
110Impulsivity (HP:0100710)1.89378756
111Cystic liver disease (HP:0006706)1.89019872
112Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88609105
113Aqueductal stenosis (HP:0002410)1.88453745
114Aplasia/Hypoplasia of the tongue (HP:0010295)1.87770627
115Hyperthyroidism (HP:0000836)1.87547919
116Diminished motivation (HP:0000745)1.86922493
117Progressive cerebellar ataxia (HP:0002073)1.86776483
118Termporal pattern (HP:0011008)1.85147614
119Insidious onset (HP:0003587)1.85147614
120Ankyloglossia (HP:0010296)1.85079310
121Renal dysplasia (HP:0000110)1.85041927
122Split foot (HP:0001839)1.83010074
123Shawl scrotum (HP:0000049)1.82971132
124Aplasia/Hypoplasia of the spleen (HP:0010451)1.82948680
125Pendular nystagmus (HP:0012043)1.82359056
126Asplenia (HP:0001746)1.82287615
127Abnormality of the lower motor neuron (HP:0002366)1.81776111
128Periorbital edema (HP:0100539)1.80425830
129Specific learning disability (HP:0001328)1.80012839
130Shallow orbits (HP:0000586)1.79980033
131Abnormal rod and cone electroretinograms (HP:0008323)1.79485582
132Type II lissencephaly (HP:0007260)1.79389887
133Cerebral inclusion bodies (HP:0100314)1.78918521
134Spastic tetraplegia (HP:0002510)1.78866977
135Rhinitis (HP:0012384)1.78796152
136Impaired vibration sensation in the lower limbs (HP:0002166)1.78764229
137High anterior hairline (HP:0009890)1.78542813
138Abnormal social behavior (HP:0012433)1.78440361
139Impaired social interactions (HP:0000735)1.78440361
140Hamartoma (HP:0010566)1.78347101
141Medial flaring of the eyebrow (HP:0010747)1.78274158
142Abnormal number of incisors (HP:0011064)1.77874374
14311 pairs of ribs (HP:0000878)1.77769340
144Bony spicule pigmentary retinopathy (HP:0007737)1.77754385
145Preaxial hand polydactyly (HP:0001177)1.77100912
146Mutism (HP:0002300)1.77063407
147Tubular atrophy (HP:0000092)1.76937400
148Depression (HP:0000716)1.75927818
149Congenital primary aphakia (HP:0007707)1.75342050
150Status epilepticus (HP:0002133)1.75125950
151Hepatoblastoma (HP:0002884)1.74990730
152Poor suck (HP:0002033)1.74938870
153Hypodontia (HP:0000668)1.74483169
154Facial edema (HP:0000282)1.74391779
155Midline defect of the nose (HP:0004122)1.72208132
156Neurofibrillary tangles (HP:0002185)1.71960603
157Oligodactyly (HP:0012165)1.71857969
158Nephrogenic diabetes insipidus (HP:0009806)1.71454936
159Intellectual disability, moderate (HP:0002342)1.71348219
160Poor eye contact (HP:0000817)1.70339113
161Thickened helices (HP:0000391)1.70114736
162Aplasia/Hypoplasia of the lens (HP:0008063)1.69028786
163Cutaneous syndactyly (HP:0012725)1.68407594
164Mask-like facies (HP:0000298)1.68285415
165Decreased testicular size (HP:0008734)1.65772627
166Autism (HP:0000717)1.65144312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.85027632
2MARK13.72610476
3ERBB33.58412497
4EPHA43.34251292
5PHKG13.03358436
6PHKG23.03358436
7DAPK22.68625126
8SIK22.53129064
9NTRK22.52576755
10NTRK32.41331419
11MAP3K42.24604463
12MAP2K72.21694179
13CASK2.11327601
14PLK22.00398146
15MAPK131.95801037
16WNK41.86149970
17MAP3K91.85587976
18MAP4K21.79384833
19TRIB31.78459928
20WNK31.69159916
21PRKD31.68010020
22MINK11.63352318
23MAPK151.62214551
24STK161.58067069
25KSR11.57524732
26CAMKK21.51043201
27MAP3K101.46970143
28PINK11.43537171
29EEF2K1.42749845
30CSNK1G21.41492818
31PAK61.41011795
32DYRK21.40158134
33BMPR21.39832975
34TYRO31.34741834
35TNIK1.26524817
36DMPK1.24670313
37MAP3K61.23672468
38MAP2K41.23524922
39TRIM281.23255061
40MAP3K111.14297387
41CAMK11.13116445
42PLK41.10732224
43CAMK1G1.10189516
44CDK51.08161765
45STK111.08040719
46PRKCG1.03693416
47DYRK1A1.02392691
48CSNK1A1L0.97549068
49PAK30.95700694
50BRAF0.95457681
51CAMK1D0.95144671
52SGK4940.93451559
53SGK2230.93451559
54NTRK10.93034382
55CDK30.92485066
56CAMK40.89522814
57CAMKK10.88823725
58SGK20.84429502
59CDK140.84090929
60FGFR20.84055690
61DAPK10.81896036
62STK380.81658238
63CDK180.81292186
64CDK150.80765341
65LATS10.78477714
66CDK190.78313842
67BRSK10.77420517
68KSR20.76936823
69CDK11A0.74307039
70CAMK2A0.74268187
71PRKCH0.73961475
72MAP3K20.73704884
73FER0.73151477
74CAMK2B0.72622576
75NEK20.72069123
76LATS20.71491155
77UHMK10.71453685
78CSNK1G30.71291422
79NUAK10.70851631
80DYRK1B0.70493952
81PRKCZ0.68983856
82MAPKAPK30.68276101
83STK390.67526162
84MARK20.63900241
85ZAK0.63480043
86ICK0.61874402
87MKNK20.61174062
88ERBB20.59502522
89CAMK2D0.58950505
90ADRBK20.58695215
91CSNK1G10.58579141
92AURKA0.58560747
93GRK10.57913600
94MKNK10.57035613
95CSNK1E0.55729381
96PIK3CA0.55357673
97PNCK0.54713923
98CDC70.54579520
99ILK0.54521272
100CAMK2G0.54041509
101DYRK30.53794175
102BCR0.52782127
103WNK10.52554743
104PRKACA0.51613442
105OXSR10.51255890
106SGK30.51135719
107CDK60.48959208
108INSRR0.47490315
109RET0.47461841
110RPS6KA20.47092707
111PRPF4B0.46818689
112BMPR1B0.44959915
113PLK10.42817595
114LMTK20.42348214
115RIPK10.42100862
116CCNB10.42008855
117TAOK10.40188863
118CDK90.39711556
119RPS6KA30.39695979
120RPS6KA60.39572155
121CSNK1A10.39280046
122PRKCE0.39139006
123PRKG10.37839066
124FYN0.37690086
125AKT10.37582685
126ACVR1B0.37219568
127GRK50.36510098
128FRK0.36477444
129HIPK20.35925485
130LIMK10.35693523
131PRKDC0.35631067
132SGK10.35093963
133ROCK10.34237124
134PKN10.33945090
135IRAK20.32092343
136MAPK90.31960732
137PTK2B0.31166186
138ROCK20.29361376
139RPS6KA10.29048459

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047404.95677603
2Nitrogen metabolism_Homo sapiens_hsa009103.76824353
3Cardiac muscle contraction_Homo sapiens_hsa042602.48457390
4Nicotine addiction_Homo sapiens_hsa050332.36709127
5Glutamatergic synapse_Homo sapiens_hsa047242.32370670
6Circadian entrainment_Homo sapiens_hsa047132.25157256
7Ribosome_Homo sapiens_hsa030102.21873492
8Synaptic vesicle cycle_Homo sapiens_hsa047212.12063317
9Oxidative phosphorylation_Homo sapiens_hsa001902.11740889
10Phototransduction_Homo sapiens_hsa047442.06415999
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02975574
12Morphine addiction_Homo sapiens_hsa050322.02382477
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.01352832
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.00554378
15Dopaminergic synapse_Homo sapiens_hsa047281.99222101
16Axon guidance_Homo sapiens_hsa043601.99056726
17GABAergic synapse_Homo sapiens_hsa047271.98675961
18Parkinsons disease_Homo sapiens_hsa050121.87738814
19Long-term potentiation_Homo sapiens_hsa047201.85441326
20Amphetamine addiction_Homo sapiens_hsa050311.82152098
21Gastric acid secretion_Homo sapiens_hsa049711.80340306
22Cholinergic synapse_Homo sapiens_hsa047251.78245543
23Salivary secretion_Homo sapiens_hsa049701.72033127
24Steroid biosynthesis_Homo sapiens_hsa001001.63131913
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.60960944
26Melanogenesis_Homo sapiens_hsa049161.58391490
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.56630012
28Insulin secretion_Homo sapiens_hsa049111.53442361
29Taste transduction_Homo sapiens_hsa047421.49469952
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48467717
31Glioma_Homo sapiens_hsa052141.47603659
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45473396
33Huntingtons disease_Homo sapiens_hsa050161.44407638
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39569329
35Basal cell carcinoma_Homo sapiens_hsa052171.38203574
36Alzheimers disease_Homo sapiens_hsa050101.38154090
37Renin secretion_Homo sapiens_hsa049241.32120073
38Dorso-ventral axis formation_Homo sapiens_hsa043201.31961893
39Oxytocin signaling pathway_Homo sapiens_hsa049211.31569724
40Serotonergic synapse_Homo sapiens_hsa047261.31436103
41GnRH signaling pathway_Homo sapiens_hsa049121.30718824
42cAMP signaling pathway_Homo sapiens_hsa040241.26091187
43Cocaine addiction_Homo sapiens_hsa050301.14957402
44Calcium signaling pathway_Homo sapiens_hsa040201.13050638
45Gap junction_Homo sapiens_hsa045401.12032733
46Alcoholism_Homo sapiens_hsa050341.11537716
47Estrogen signaling pathway_Homo sapiens_hsa049151.11302253
48Long-term depression_Homo sapiens_hsa047301.10103966
49ErbB signaling pathway_Homo sapiens_hsa040121.09611192
50Linoleic acid metabolism_Homo sapiens_hsa005911.06743169
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06573258
52Wnt signaling pathway_Homo sapiens_hsa043101.06404839
53Hedgehog signaling pathway_Homo sapiens_hsa043401.05405637
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03032248
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00464816
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.99277212
57Butanoate metabolism_Homo sapiens_hsa006500.97850248
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97780460
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.93670400
60Colorectal cancer_Homo sapiens_hsa052100.93486597
61Notch signaling pathway_Homo sapiens_hsa043300.93459163
62Hippo signaling pathway_Homo sapiens_hsa043900.91473786
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91176854
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91051916
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89429047
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88925328
67Endometrial cancer_Homo sapiens_hsa052130.87574458
68Ether lipid metabolism_Homo sapiens_hsa005650.86285486
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83804228
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83100961
71Fanconi anemia pathway_Homo sapiens_hsa034600.81771264
72Collecting duct acid secretion_Homo sapiens_hsa049660.79268731
73Ras signaling pathway_Homo sapiens_hsa040140.79104387
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79095108
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79022013
76Rap1 signaling pathway_Homo sapiens_hsa040150.75487985
77Oocyte meiosis_Homo sapiens_hsa041140.75345964
78Glucagon signaling pathway_Homo sapiens_hsa049220.74871125
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73347913
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73065013
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72354180
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.71203551
83Fatty acid biosynthesis_Homo sapiens_hsa000610.70704424
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.69463916
85Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69307867
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68805770
87Type II diabetes mellitus_Homo sapiens_hsa049300.68650253
88Tight junction_Homo sapiens_hsa045300.68061606
89VEGF signaling pathway_Homo sapiens_hsa043700.66188019
90Insulin signaling pathway_Homo sapiens_hsa049100.65998414
91Basal transcription factors_Homo sapiens_hsa030220.64336199
92MAPK signaling pathway_Homo sapiens_hsa040100.62620405
93Regulation of autophagy_Homo sapiens_hsa041400.61940262
94Chronic myeloid leukemia_Homo sapiens_hsa052200.61736710
95Ovarian steroidogenesis_Homo sapiens_hsa049130.61398800
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60700957
97Renal cell carcinoma_Homo sapiens_hsa052110.60551421
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60382153
99Protein export_Homo sapiens_hsa030600.58900398
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55782880
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54618239
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51727689
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51317747
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.50831034
105TGF-beta signaling pathway_Homo sapiens_hsa043500.50542531
106Choline metabolism in cancer_Homo sapiens_hsa052310.50533181
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49553580
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.48582133
109Sulfur relay system_Homo sapiens_hsa041220.48115916
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48097472
111Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46547237
112FoxO signaling pathway_Homo sapiens_hsa040680.46448010
113Tryptophan metabolism_Homo sapiens_hsa003800.46330210
114Bile secretion_Homo sapiens_hsa049760.45874402
115Non-small cell lung cancer_Homo sapiens_hsa052230.45247062
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45203888
117mTOR signaling pathway_Homo sapiens_hsa041500.44622265
118Pancreatic secretion_Homo sapiens_hsa049720.44368985
119Melanoma_Homo sapiens_hsa052180.43813873
120Adherens junction_Homo sapiens_hsa045200.43506772
121Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43366060
122Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42455900
123Dilated cardiomyopathy_Homo sapiens_hsa054140.42036920
124Circadian rhythm_Homo sapiens_hsa047100.41519152
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41345405
126Vitamin B6 metabolism_Homo sapiens_hsa007500.40989528
127Glycerolipid metabolism_Homo sapiens_hsa005610.40749779
128Arginine and proline metabolism_Homo sapiens_hsa003300.40733272
129Proteoglycans in cancer_Homo sapiens_hsa052050.40676506
130Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40190754
131Pancreatic cancer_Homo sapiens_hsa052120.40071697
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38840435
133Thyroid hormone synthesis_Homo sapiens_hsa049180.38716951
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38333198
135Peroxisome_Homo sapiens_hsa041460.37689241

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