LHFPL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.64819004
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.64819004
3positive regulation by organism of defense response of other organism involved in symbiotic interact5.64819004
4modulation by symbiont of host immune response (GO:0052553)5.64819004
5positive regulation by symbiont of host defense response (GO:0052509)5.64819004
6modulation by symbiont of host defense response (GO:0052031)5.64819004
7oligosaccharide catabolic process (GO:0009313)5.26518407
8negative regulation of interleukin-12 production (GO:0032695)4.82134281
9regulation of interferon-beta biosynthetic process (GO:0045357)4.75442424
10response to peptidoglycan (GO:0032494)4.69855865
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.65960732
12low-density lipoprotein particle clearance (GO:0034383)4.34793614
13macrophage activation involved in immune response (GO:0002281)4.26544069
14ceramide catabolic process (GO:0046514)4.22835594
15keratan sulfate catabolic process (GO:0042340)4.14498458
16amino sugar catabolic process (GO:0046348)4.03315718
17detection of molecule of bacterial origin (GO:0032490)3.81558493
18microglial cell activation (GO:0001774)3.74891205
19substrate-dependent cell migration (GO:0006929)3.73164044
20lipopolysaccharide-mediated signaling pathway (GO:0031663)3.67942115
21positive regulation of monocyte chemotaxis (GO:0090026)3.67461475
22apoptotic cell clearance (GO:0043277)3.65305681
23positive regulation of leukocyte degranulation (GO:0043302)3.65140831
24membrane lipid catabolic process (GO:0046466)3.63717737
25N-acetylneuraminate metabolic process (GO:0006054)3.61065157
26positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.59494346
27cell adhesion mediated by integrin (GO:0033627)3.57831967
28T-helper 1 type immune response (GO:0042088)3.57718500
29protein localization to endosome (GO:0036010)3.57007197
30phagocytosis, recognition (GO:0006910)3.55123185
31regulation of vitamin D biosynthetic process (GO:0060556)3.48482191
32regulation of cholesterol storage (GO:0010885)3.39666026
33barbed-end actin filament capping (GO:0051016)3.39304562
34neutrophil activation involved in immune response (GO:0002283)3.38959843
35collagen fibril organization (GO:0030199)3.38292467
36response to host immune response (GO:0052572)3.37531387
37response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37531387
38basement membrane organization (GO:0071711)3.37133159
39collagen catabolic process (GO:0030574)3.35248606
40regulation of mononuclear cell migration (GO:0071675)3.34050274
41positive regulation of chemokine biosynthetic process (GO:0045080)3.33947732
42sphingolipid catabolic process (GO:0030149)3.33382158
43collagen metabolic process (GO:0032963)3.32940949
44positive regulation of cellular amide metabolic process (GO:0034250)3.32222234
45protein heterotrimerization (GO:0070208)3.31210453
46monocyte chemotaxis (GO:0002548)3.29433643
47axon extension involved in axon guidance (GO:0048846)3.28380240
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.28380240
49dermatan sulfate biosynthetic process (GO:0030208)3.27637011
50response to host (GO:0075136)3.26986122
51response to host defenses (GO:0052200)3.26986122
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.26986122
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23328479
54regulation of monocyte chemotaxis (GO:0090025)3.20860912
55cellular response to arsenic-containing substance (GO:0071243)3.19320380
56regulation of podosome assembly (GO:0071801)3.18851986
57pinocytosis (GO:0006907)3.15930009
58positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.15415141
59regulation of chemokine-mediated signaling pathway (GO:0070099)3.15198259
60regulation of membrane protein ectodomain proteolysis (GO:0051043)3.14800032
61multicellular organismal macromolecule metabolic process (GO:0044259)3.14569616
62regulation of mast cell degranulation (GO:0043304)3.14138844
63positive regulation of mast cell activation (GO:0033005)3.12926589
64positive regulation of cholesterol efflux (GO:0010875)3.11973180
65dermatan sulfate metabolic process (GO:0030205)3.10192356
66positive regulation of macrophage cytokine production (GO:0060907)3.09447110
67negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.08342635
68positive regulation of mast cell degranulation (GO:0043306)3.08268158
69positive regulation of mast cell activation involved in immune response (GO:0033008)3.08268158
70negative regulation of nitric oxide biosynthetic process (GO:0045019)3.07277848
71multicellular organismal catabolic process (GO:0044243)3.06946360
72L-amino acid import (GO:0043092)3.04898257
73semaphorin-plexin signaling pathway (GO:0071526)3.04884720
74cellular response to thyroid hormone stimulus (GO:0097067)3.04631933
75adenosine receptor signaling pathway (GO:0001973)3.03603701
76regulation of leukocyte degranulation (GO:0043300)3.03538899
77cellular extravasation (GO:0045123)3.02056685
78cortical actin cytoskeleton organization (GO:0030866)2.97049331
79multicellular organismal metabolic process (GO:0044236)2.96468402
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95652948
81wound healing, spreading of epidermal cells (GO:0035313)2.95352727
82negative regulation of lipid storage (GO:0010888)2.93885740
83regulation of mast cell activation involved in immune response (GO:0033006)2.93285811
84glycosphingolipid catabolic process (GO:0046479)2.91831818
85macrophage activation (GO:0042116)2.91268682
86osteoclast differentiation (GO:0030316)2.90550036
87positive regulation of interferon-alpha production (GO:0032727)2.89864451
88endodermal cell differentiation (GO:0035987)2.89260045
89immunoglobulin mediated immune response (GO:0016064)2.88465615
90amino acid import (GO:0043090)2.88018547
91response to lipoprotein particle (GO:0055094)2.87958817
92I-kappaB phosphorylation (GO:0007252)2.86529875
93regulation of vitamin metabolic process (GO:0030656)2.86370946
94regulation of cytokine secretion involved in immune response (GO:0002739)2.85350596
95hyaluronan catabolic process (GO:0030214)2.83374961
96mannose metabolic process (GO:0006013)2.83312880
97regulation of macrophage cytokine production (GO:0010935)2.83000782
98negative regulation of smooth muscle cell migration (GO:0014912)2.80922918
99germinal center formation (GO:0002467)2.80261119
100regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79670569
101glomerular filtration (GO:0003094)2.78210768
102positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78130655
103positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.78130489
104eosinophil chemotaxis (GO:0048245)2.76314571
105chondroitin sulfate catabolic process (GO:0030207)2.75844504
106vascular endothelial growth factor signaling pathway (GO:0038084)2.75256377
107extracellular matrix disassembly (GO:0022617)2.74857179
108retina vasculature morphogenesis in camera-type eye (GO:0061299)2.74574843
109detection of external biotic stimulus (GO:0098581)2.74535186
110positive regulation of bone remodeling (GO:0046852)2.73496673
111positive regulation of bone resorption (GO:0045780)2.73496673
112glial cell migration (GO:0008347)2.70939202
113peptide catabolic process (GO:0043171)2.70710744
114regulation of interferon-alpha production (GO:0032647)2.70467471
115regulation of macrophage chemotaxis (GO:0010758)2.70379789
116regulation of mast cell activation (GO:0033003)2.69933690
117regulation of chemokine biosynthetic process (GO:0045073)2.69931607
118macrophage differentiation (GO:0030225)2.69268489
119regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.69081207
120myeloid dendritic cell differentiation (GO:0043011)2.67919036
121positive regulation of gamma-delta T cell activation (GO:0046645)2.67891009
122germ cell migration (GO:0008354)2.67088596
123regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.66834970
124decidualization (GO:0046697)2.64921209
125cellular response to lipopolysaccharide (GO:0071222)2.64053114
126virion attachment to host cell (GO:0019062)2.64013395
127adhesion of symbiont to host cell (GO:0044650)2.64013395
128fat-soluble vitamin biosynthetic process (GO:0042362)2.63771305
129positive regulation of extracellular matrix organization (GO:1903055)2.63169250
130regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.60392354
131positive regulation of cholesterol transport (GO:0032376)2.60177457
132positive regulation of sterol transport (GO:0032373)2.60177457
133NIK/NF-kappaB signaling (GO:0038061)2.60024454
134negative regulation of interleukin-17 production (GO:0032700)2.59474147
135negative regulation of granulocyte differentiation (GO:0030853)2.59398894
136positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.59057136
137positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59055906
138cortical cytoskeleton organization (GO:0030865)2.58406262
139regulation of early endosome to late endosome transport (GO:2000641)2.58108840
140cellular response to molecule of bacterial origin (GO:0071219)2.57925905
141granulocyte activation (GO:0036230)2.57296657
142positive regulation of p38MAPK cascade (GO:1900745)2.56781151
143response to fluid shear stress (GO:0034405)2.56320187
144lipoprotein transport (GO:0042953)2.56027382
145regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.55016238
146stress fiber assembly (GO:0043149)2.54091444
147myeloid cell activation involved in immune response (GO:0002275)2.54087679
148positive regulation of interleukin-6 production (GO:0032755)2.53685683
149response to laminar fluid shear stress (GO:0034616)2.53629888
150interferon-gamma-mediated signaling pathway (GO:0060333)2.53538856
151negative regulation of cytokine production involved in immune response (GO:0002719)2.53216990
152positive regulation of heat generation (GO:0031652)2.53161858
153fibroblast migration (GO:0010761)2.52869477
154response to muramyl dipeptide (GO:0032495)2.52581685
155glycolipid catabolic process (GO:0019377)2.52359740
156regulation of SMAD protein import into nucleus (GO:0060390)2.51352647
157regulation of smooth muscle cell migration (GO:0014910)2.50404471
158epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49020685
159negative regulation of mast cell activation (GO:0033004)2.48521110
160positive regulation of insulin receptor signaling pathway (GO:0046628)2.47885079
161import into cell (GO:0098657)2.47173960
162renal filtration (GO:0097205)2.45961434
163positive regulation of antigen processing and presentation (GO:0002579)2.43550640
164chondrocyte proliferation (GO:0035988)2.43324602
165regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.43182511
166ovulation from ovarian follicle (GO:0001542)2.42942388
167dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42193909
168phagocytosis, engulfment (GO:0006911)2.39211794
169glycoprotein catabolic process (GO:0006516)2.38734065
170response to thyroid hormone (GO:0097066)2.38730689
171iron ion import (GO:0097286)2.38606691
172leukocyte migration involved in inflammatory response (GO:0002523)2.37985052
173positive regulation vascular endothelial growth factor production (GO:0010575)2.37921114
174platelet-derived growth factor receptor signaling pathway (GO:0048008)2.37181921
175negative regulation of phagocytosis (GO:0050765)2.34536728

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.73563211
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.70167826
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.64190538
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.44250144
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13451554
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09780132
7* IRF8_27001747_Chip-Seq_BMDM_Mouse2.98349023
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62348972
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.50611765
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.40914003
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.33881217
12STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.31602479
13CLOCK_20551151_ChIP-Seq_293T_Human2.31547743
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27509610
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.24906516
16* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.18435526
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.17887539
18VDR_24787735_ChIP-Seq_THP-1_Human2.17157364
19GATA1_22025678_ChIP-Seq_K562_Human2.15150050
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14695059
21* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.13549725
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13070305
23* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07842123
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06592889
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03564500
26* NRF2_20460467_ChIP-Seq_MEFs_Mouse2.00577164
27* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.00577164
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99749761
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.99574207
30* CJUN_26792858_Chip-Seq_BT549_Human1.92076420
31GATA2_21666600_ChIP-Seq_HMVEC_Human1.83813837
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78714010
33* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.78645002
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.76622429
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75670998
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74072211
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.64487600
38SPI1_23547873_ChIP-Seq_NB4_Human1.63508416
39* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.63346024
40SPI1_23127762_ChIP-Seq_K562_Human1.62996602
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.62962641
42MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62908555
43* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62197758
44* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.53542350
45SOX2_20726797_ChIP-Seq_SW620_Human1.52384533
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52358653
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51849621
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.51189297
49* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.50644664
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.50198535
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.48364771
52* BRD4_25478319_ChIP-Seq_HGPS_Human1.46288043
53CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44913806
54* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44020961
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43145381
56* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42419086
57VDR_24763502_ChIP-Seq_THP-1_Human1.41682255
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41670741
59TFEB_21752829_ChIP-Seq_HELA_Human1.40943151
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40578524
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39250325
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38621020
63TP53_16413492_ChIP-PET_HCT116_Human1.37552071
64P300_27058665_Chip-Seq_ZR-75-30cells_Human1.36597162
65* FOXO3_23340844_ChIP-Seq_DLD1_Human1.36346023
66VDR_21846776_ChIP-Seq_THP-1_Human1.35920421
67CDX2_20551321_ChIP-Seq_CACO-2_Human1.33414658
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32856383
69RUNX1_22412390_ChIP-Seq_EML_Mouse1.31672256
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31342506
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30944055
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30823013
73PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28266872
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27098336
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25913298
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24795434
77RXR_22108803_ChIP-Seq_LS180_Human1.24722577
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.24312343
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21405851
80CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19991001
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19625121
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19200959
83PU_27001747_Chip-Seq_BMDM_Mouse1.18939828
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18593283
85SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.17393331
86SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.17393331
87TP53_18474530_ChIP-ChIP_U2OS_Human1.15942857
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15518556
89GATA1_19941827_ChIP-Seq_MEL_Mouse1.14612553
90RUNX_20019798_ChIP-Seq_JUKART_Human1.14533185
91STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13688054
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12532173
93FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12487540
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.11176958
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10014815
96* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09001321
97GATA1_19941826_ChIP-Seq_K562_Human1.08832905
98LXR_22158963_ChIP-Seq_LIVER_Mouse1.08465133
99HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08333467
100* EP300_21415370_ChIP-Seq_HL-1_Mouse1.08021152
101MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07964300
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06058471
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04941824
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04389786
105ESR1_20079471_ChIP-ChIP_T-47D_Human1.02169428
106LXR_22292898_ChIP-Seq_THP-1_Human1.02075653
107* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01991420
108TCF7_22412390_ChIP-Seq_EML_Mouse1.01533085
109* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01006676
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00595650
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00162688
112AR_21572438_ChIP-Seq_LNCaP_Human0.98984581
113* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98920335
114CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98584459
115FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98533801
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97404480
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96964672
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95610812
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95342659
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95131668
121SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94660170
122KDM2B_26808549_Chip-Seq_DND41_Human0.91735682
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.89931052
124* GATA2_19941826_ChIP-Seq_K562_Human0.88657367
125RXR_22158963_ChIP-Seq_LIVER_Mouse0.88511027
126ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88275160
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.87872275
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.87872275
129* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.87866126
130* KDM2B_26808549_Chip-Seq_K562_Human0.87478964
131SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87108931
132UBF1/2_26484160_Chip-Seq_HMECs_Human0.86679909
133SCL_19346495_ChIP-Seq_HPC-7_Human0.84847415
134* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84325990

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.26587810
2MP0005257_abnormal_intraocular_pressure4.07565341
3MP0005058_abnormal_lysosome_morphology3.96573535
4MP0003172_abnormal_lysosome_physiology3.39089851
5MP0005275_abnormal_skin_tensile3.04675691
6MP0003705_abnormal_hypodermis_morpholog3.02583579
7MP0005503_abnormal_tendon_morphology2.77983982
8MP0004272_abnormal_basement_membrane2.66906141
9MP0000569_abnormal_digit_pigmentation2.56892455
10MP0002139_abnormal_hepatobiliary_system2.48193788
11MP0003690_abnormal_glial_cell2.40702211
12MP0001958_emphysema2.33046663
13MP0003279_aneurysm2.27799205
14MP0003303_peritoneal_inflammation2.16664060
15MP0006082_CNS_inflammation2.14823729
16MP0010368_abnormal_lymphatic_system2.11856154
17MP0009785_altered_susceptibility_to2.08651588
18MP0003191_abnormal_cellular_cholesterol2.07252082
19MP0004185_abnormal_adipocyte_glucose2.06166366
20MP0003300_gastrointestinal_ulcer2.01755836
21MP0002254_reproductive_system_inflammat1.97934908
22MP0003566_abnormal_cell_adhesion1.95301627
23MP0002877_abnormal_melanocyte_morpholog1.92526323
24MP0006054_spinal_hemorrhage1.91508965
25MP0005387_immune_system_phenotype1.90819312
26MP0001790_abnormal_immune_system1.90819312
27MP0005623_abnormal_meninges_morphology1.79607607
28MP0000685_abnormal_immune_system1.78236841
29MP0005451_abnormal_body_composition1.75887744
30MP0002998_abnormal_bone_remodeling1.73417950
31MP0005671_abnormal_response_to1.73188508
32MP0005025_abnormal_response_to1.70576098
33MP0009764_decreased_sensitivity_to1.69435201
34MP0009384_cardiac_valve_regurgitation1.68878326
35MP0003453_abnormal_keratinocyte_physiol1.67954530
36MP0005171_absent_coat_pigmentation1.67908129
37MP0004130_abnormal_muscle_cell1.66725459
38MP0001853_heart_inflammation1.61583473
39MP0001533_abnormal_skeleton_physiology1.61203321
40MP0001879_abnormal_lymphatic_vessel1.59995056
41MP0003091_abnormal_cell_migration1.55623591
42MP0002419_abnormal_innate_immunity1.54525734
43MP0005670_abnormal_white_adipose1.52595504
44MP0003329_amyloid_beta_deposits1.50704446
45MP0000343_altered_response_to1.49590792
46MP0003436_decreased_susceptibility_to1.49037782
47MP0005310_abnormal_salivary_gland1.46434828
48MP0004947_skin_inflammation1.42382849
49MP0002723_abnormal_immune_serum1.42024514
50MP0005666_abnormal_adipose_tissue1.40800670
51MP0001845_abnormal_inflammatory_respons1.38226541
52MP0008004_abnormal_stomach_pH1.37585278
53MP0000767_abnormal_smooth_muscle1.35014453
54MP0001545_abnormal_hematopoietic_system1.34014515
55MP0005397_hematopoietic_system_phenotyp1.34014515
56MP0005508_abnormal_skeleton_morphology1.33520879
57MP0005023_abnormal_wound_healing1.33277544
58MP0000733_abnormal_muscle_development1.32896002
59MP0005390_skeleton_phenotype1.30315853
60MP0002405_respiratory_system_inflammati1.28848009
61MP0002295_abnormal_pulmonary_circulatio1.28802251
62MP0009840_abnormal_foam_cell1.26311162
63MP0004134_abnormal_chest_morphology1.25654848
64MP0009278_abnormal_bone_marrow1.25301727
65MP0000604_amyloidosis1.25250330
66MP0008469_abnormal_protein_level1.24624289
67MP0003448_altered_tumor_morphology1.20723418
68MP0005167_abnormal_blood-brain_barrier1.19505004
69MP0001800_abnormal_humoral_immune1.19301104
70MP0002090_abnormal_vision1.18726502
71MP0001819_abnormal_immune_cell1.17104160
72MP0002420_abnormal_adaptive_immunity1.16559458
73MP0003656_abnormal_erythrocyte_physiolo1.16541875
74MP0000371_diluted_coat_color1.16243723
75MP0004858_abnormal_nervous_system1.16063271
76MP0005375_adipose_tissue_phenotype1.10630371
77MP0010155_abnormal_intestine_physiology1.10574632
78MP0005197_abnormal_uvea_morphology1.09776555
79MP0000920_abnormal_myelination1.08731111
80MP0002933_joint_inflammation1.08669723
81MP0003724_increased_susceptibility_to1.08536126
82MP0010307_abnormal_tumor_latency1.08485514
83MP0005164_abnormal_response_to1.05926190
84MP0003385_abnormal_body_wall1.04323491
85MP0001299_abnormal_eye_distance/1.03738151
86MP0003828_pulmonary_edema1.03383197
87MP0005165_increased_susceptibility_to1.03010661
88MP0005464_abnormal_platelet_physiology1.01342159
89MP0005076_abnormal_cell_differentiation1.00220899
90MP0001915_intracranial_hemorrhage0.99960320
91MP0008260_abnormal_autophagy0.99946112
92MP0001851_eye_inflammation0.99032633
93MP0002115_abnormal_skeleton_extremities0.98883811
94MP0003950_abnormal_plasma_membrane0.98469258
95MP0003045_fibrosis0.98041719
96MP0003634_abnormal_glial_cell0.97556939
97MP0002060_abnormal_skin_morphology0.97435293
98MP0009115_abnormal_fat_cell0.96074539
99MP0005595_abnormal_vascular_smooth0.95121054
100MP0002108_abnormal_muscle_morphology0.93714862
101MP0002113_abnormal_skeleton_development0.93613144
102MP0001835_abnormal_antigen_presentation0.93094956
103MP0009250_abnormal_appendicular_skeleto0.92686323
104MP0004510_myositis0.92590391
105MP0002896_abnormal_bone_mineralization0.92526440
106MP0003795_abnormal_bone_structure0.88972139
107MP0001849_ear_inflammation0.88946744
108MP0003806_abnormal_nucleotide_metabolis0.87004078
109MP0002133_abnormal_respiratory_system0.85279638
110MP0005388_respiratory_system_phenotype0.85279638
111MP0001614_abnormal_blood_vessel0.83770260
112MP0005000_abnormal_immune_tolerance0.83598872
113MP0009333_abnormal_splenocyte_physiolog0.83385184
114MP0001542_abnormal_bone_strength0.82638356
115MP0003075_altered_response_to0.81214668
116MP0001243_abnormal_dermal_layer0.80688614
117MP0000163_abnormal_cartilage_morphology0.78665174
118MP0005365_abnormal_bile_salt0.78228951
119MP0000003_abnormal_adipose_tissue0.77811506
120MP0002282_abnormal_trachea_morphology0.76918677
121MP0009763_increased_sensitivity_to0.76778337
122MP0002452_abnormal_antigen_presenting0.76404405
123MP0010234_abnormal_vibrissa_follicle0.75463811
124MP0004883_abnormal_blood_vessel0.74924857
125MP0003195_calcinosis0.74843970
126MP0000249_abnormal_blood_vessel0.74634263
127MP0000858_altered_metastatic_potential0.74476813
128MP0000465_gastrointestinal_hemorrhage0.74302193
129MP0002168_other_aberrant_phenotype0.73999112
130MP0001175_abnormal_lung_morphology0.72515365
131MP0000716_abnormal_immune_system0.72352221
132MP0005647_abnormal_sex_gland0.72010708
133MP0002128_abnormal_blood_circulation0.71146742
134MP0003183_abnormal_peptide_metabolism0.68692242
135MP0010352_gastrointestinal_tract_polyps0.67606646
136MP0005193_abnormal_anterior_eye0.67440445
137MP0009053_abnormal_anal_canal0.66752732
138MP0002148_abnormal_hypersensitivity_rea0.65982101
139MP0000013_abnormal_adipose_tissue0.65349041
140MP0004019_abnormal_vitamin_homeostasis0.64900067
141MP0005166_decreased_susceptibility_to0.64509204
142MP0003011_delayed_dark_adaptation0.63659741
143MP0000428_abnormal_craniofacial_morphol0.62672213

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)5.70821813
2Premature rupture of membranes (HP:0001788)4.63920183
3Increased neuronal autofluorescent lipopigment (HP:0002074)4.54330371
4Protrusio acetabuli (HP:0003179)4.50519142
5Abnormality of glycolipid metabolism (HP:0010969)4.25544124
6Abnormality of liposaccharide metabolism (HP:0010968)4.25544124
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.25544124
8Vacuolated lymphocytes (HP:0001922)4.17384972
9Cerebral aneurysm (HP:0004944)4.16115619
10Dysostosis multiplex (HP:0000943)4.11238861
11Neurofibrillary tangles (HP:0002185)4.08892611
12Aortic dissection (HP:0002647)3.92924925
13Mutism (HP:0002300)3.62859273
14Disinhibition (HP:0000734)3.61288516
15Arterial tortuosity (HP:0005116)3.51526738
16Mucopolysacchariduria (HP:0008155)3.42302544
17Urinary glycosaminoglycan excretion (HP:0003541)3.42302544
18Ankle contracture (HP:0006466)3.36241305
19Shallow orbits (HP:0000586)3.30112104
20Aortic aneurysm (HP:0004942)3.28619191
21Vascular tortuosity (HP:0004948)3.27117503
22Systemic lupus erythematosus (HP:0002725)3.25224207
23Recurrent abscess formation (HP:0002722)3.24597561
24Soft skin (HP:0000977)3.23657984
25Nuclear cataract (HP:0100018)3.23192036
26Abnormality of polysaccharide metabolism (HP:0011012)3.21402683
27Abnormality of glycosaminoglycan metabolism (HP:0004371)3.21402683
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.21402683
29Broad metatarsal (HP:0001783)3.11511946
30Axonal loss (HP:0003447)3.08536986
31Spondylolisthesis (HP:0003302)3.04861385
32Cerebral inclusion bodies (HP:0100314)3.04553431
33Autoimmune thrombocytopenia (HP:0001973)3.03119470
34Vertebral compression fractures (HP:0002953)2.94897973
35Cervical subluxation (HP:0003308)2.90374286
36Mediastinal lymphadenopathy (HP:0100721)2.90035858
37Mitral valve prolapse (HP:0001634)2.84230270
38Abnormality of macrophages (HP:0004311)2.78559169
39Dilatation of the ascending aorta (HP:0005111)2.69955058
40Complement deficiency (HP:0004431)2.64593094
41Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.64046932
42Myocardial infarction (HP:0001658)2.63106880
43Agnosia (HP:0010524)2.62650223
44Eczematoid dermatitis (HP:0000976)2.58910927
45Striae distensae (HP:0001065)2.56351581
46Metaphyseal irregularity (HP:0003025)2.54022665
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.52335315
48Recurrent gram-negative bacterial infections (HP:0005420)2.51963986
49Recurrent bacterial skin infections (HP:0005406)2.50550144
50Hematochezia (HP:0002573)2.49635246
51Blue sclerae (HP:0000592)2.46202618
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.45993380
53Osteolytic defects of the hand bones (HP:0009699)2.45993380
54Purpura (HP:0000979)2.45794565
55Loss of speech (HP:0002371)2.45075369
56Bladder diverticulum (HP:0000015)2.43705313
57Peritonitis (HP:0002586)2.38330678
58Disproportionate tall stature (HP:0001519)2.37298601
59Abnormality of the periventricular white matter (HP:0002518)2.34577465
60Atrophic scars (HP:0001075)2.31912625
61Ovoid vertebral bodies (HP:0003300)2.31241396
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.23149417
63Abnormality of the lumbar spine (HP:0100712)2.22164426
64Orchitis (HP:0100796)2.20168527
65Follicular hyperkeratosis (HP:0007502)2.19849071
66Tetraparesis (HP:0002273)2.19336256
67Genu recurvatum (HP:0002816)2.18893072
68Abnormality of complement system (HP:0005339)2.18881071
69Dementia (HP:0000726)2.13793569
70Spontaneous hematomas (HP:0007420)2.12312368
71Glomerulonephritis (HP:0000099)2.11624827
72Peripheral demyelination (HP:0011096)2.10382806
73Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.09947530
74Progressive neurologic deterioration (HP:0002344)2.09858260
75J-shaped sella turcica (HP:0002680)2.08489279
76Fragile skin (HP:0001030)2.07518258
77Broad ribs (HP:0000885)2.07379943
78Global brain atrophy (HP:0002283)2.04267505
79Amyloidosis (HP:0011034)2.04227273
80Abnormality of the frontal sinuses (HP:0002687)2.03998825
81Gingivitis (HP:0000230)2.03559477
82Increased CSF protein (HP:0002922)2.03276584
83Increased serum ferritin (HP:0003281)2.00684710
84Pathologic fracture (HP:0002756)2.00298903
85Slender build (HP:0001533)2.00165316
86Personality changes (HP:0000751)1.99119775
87Bone cyst (HP:0012062)1.98810842
88Hepatosplenomegaly (HP:0001433)1.98153952
89Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97586486
90Neuronal loss in central nervous system (HP:0002529)1.97547624
91Asymmetry of the thorax (HP:0001555)1.97192306
92Joint laxity (HP:0001388)1.97103332
93Wormian bones (HP:0002645)1.96792602
94Hyperextensible skin (HP:0000974)1.95575891
95Optic neuritis (HP:0100653)1.94821392
96Retrobulbar optic neuritis (HP:0100654)1.94821392
97Xanthomatosis (HP:0000991)1.93846406
98Conjunctival telangiectasia (HP:0000524)1.92386132
99Cardiomegaly (HP:0001640)1.92130826
100Esophageal varix (HP:0002040)1.91696493
101Aneurysm (HP:0002617)1.90145152
102Recurrent skin infections (HP:0001581)1.88454248
103Ulnar bowing (HP:0003031)1.87575106
104Progressive visual loss (HP:0000529)1.87373970
105Coarse hair (HP:0002208)1.85188282
106Spinal rigidity (HP:0003306)1.84403226
107Pulmonary infiltrates (HP:0002113)1.84214208
108Nonimmune hydrops fetalis (HP:0001790)1.84140931
109Short 4th metacarpal (HP:0010044)1.83721941
110Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83721941
111Abnormality of the peritoneum (HP:0002585)1.83315106
112Skin nodule (HP:0200036)1.82937573
113Thick nail (HP:0001805)1.80590375
114Thin bony cortex (HP:0002753)1.80275292
115Camptodactyly of toe (HP:0001836)1.78978743
116Nephritis (HP:0000123)1.78771097
117Abnormality of the acetabulum (HP:0003170)1.78764617
118Asymmetric septal hypertrophy (HP:0001670)1.78024364
119Inappropriate behavior (HP:0000719)1.77678816
120Basal ganglia calcification (HP:0002135)1.77602297
121Protuberant abdomen (HP:0001538)1.77414109
122Myositis (HP:0100614)1.77294895
123Type 1 muscle fiber predominance (HP:0003803)1.77256487
124Biconcave vertebral bodies (HP:0004586)1.76986692
125Thoracic kyphosis (HP:0002942)1.76376791
126Prolonged neonatal jaundice (HP:0006579)1.75949603
127Malnutrition (HP:0004395)1.75736389
128Upper motor neuron abnormality (HP:0002127)1.75702550
129Bone pain (HP:0002653)1.73581692
130Apathy (HP:0000741)1.73439168
131Syringomyelia (HP:0003396)1.72244833
132Spinal cord lesions (HP:0100561)1.72244833
133Diminished motivation (HP:0000745)1.72231875
134Petechiae (HP:0000967)1.70617183
135Deviation of the hallux (HP:0010051)1.70464033
136Polyneuropathy (HP:0001271)1.69412430
137Femoral bowing (HP:0002980)1.69130139
138Retinal atrophy (HP:0001105)1.68822222
139Beaking of vertebral bodies (HP:0004568)1.67837994
140Turricephaly (HP:0000262)1.66854709
141Chronic obstructive pulmonary disease (HP:0006510)1.66067161
142Obstructive lung disease (HP:0006536)1.66067161
143Esophageal neoplasm (HP:0100751)1.61695283
144Neoplasm of head and neck (HP:0012288)1.61695283
145Premature loss of primary teeth (HP:0006323)1.60735047
146Mucosal telangiectasiae (HP:0100579)1.60609766
147Multiple enchondromatosis (HP:0005701)1.58104709
148Nausea (HP:0002018)1.57937883
149Abnormality of iron homeostasis (HP:0011031)1.56819851

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR23.94274446
2TRIB33.69813495
3CAMK1D3.24713642
4NME23.19761756
5GRK73.15606020
6ACVR1B2.89702486
7KIT2.83337548
8MAP3K142.68449286
9DDR22.60241885
10CAMK1G2.46944633
11PKN22.37806492
12ERN12.36301141
13PDGFRA2.35623244
14EPHB12.30065209
15PAK42.19594653
16TTN2.06763013
17FES2.02448349
18RIPK12.01287900
19SIK12.00001126
20PRPF4B1.96524747
21NEK91.92046136
22PTK61.88974106
23TBK11.76406050
24PDGFRB1.76306854
25CDC42BPA1.69702035
26CSF1R1.69117572
27SCYL21.62876131
28PDK21.62472863
29LATS11.52493159
30CAMKK21.49274098
31MAP3K131.42979579
32KDR1.34854470
33TYRO31.32485834
34JAK11.32261154
35PAK21.31051385
36EPHB21.24605853
37CSK1.23451053
38EPHA31.21261920
39ABL21.21170843
40CDK61.18881470
41MAP2K31.18408162
42MAP3K111.17604723
43ZAP701.17603399
44TRPM71.17469171
45STK241.16015196
46RIPK41.14777805
47BMX1.12421282
48TYK21.09657621
49PTK21.03453420
50FGR1.01703984
51PBK0.97976764
52BMPR20.96610474
53ADRBK20.94236571
54KSR20.93544776
55STK30.93083743
56IKBKE0.92692961
57RET0.91460896
58TAOK10.90603077
59LRRK20.89628839
60MOS0.89311803
61IRAK40.88473629
62PTK2B0.87961508
63TIE10.87915234
64MAP3K10.87535972
65CAMKK10.87494651
66HCK0.85874255
67IRAK20.83401752
68IRAK30.82901067
69MET0.82610626
70INSR0.78614087
71ERBB40.78491664
72MAP3K30.78222680
73CHUK0.78150424
74LATS20.78075270
75STK100.76264051
76MAP3K20.75940407
77MATK0.74306120
78PRKCH0.72246472
79FRK0.72223946
80IGF1R0.71074140
81JAK20.70778345
82MAP3K50.70685706
83PIK3CA0.69604383
84SRC0.68806539
85GSK3A0.67215123
86DMPK0.66484301
87CDK90.66068073
88ICK0.64762116
89NUAK10.64693960
90IRAK10.64419917
91STK38L0.63744125
92RPS6KA40.63471166
93ABL10.63422717
94FGFR30.63228321
95EGFR0.62630139
96LMTK20.62227175
97TGFBR10.62024735
98JAK30.62010519
99MAPK70.61948449
100MST1R0.61540684
101LYN0.59240301
102PDPK10.57255049
103FER0.57132396
104LCK0.56548700
105TESK10.56179224
106FYN0.55718422
107ARAF0.55058815
108TAOK20.53906021
109MAP2K10.53547167
110SYK0.52952345
111RPS6KA20.51756500
112MARK30.51202280
113MTOR0.51144673
114FGFR20.51139013
115ITK0.48263800
116MAP4K10.47609273
117MELK0.46401639
118LIMK10.45948675
119BMPR1B0.45522033
120TESK20.45485705
121RPS6KL10.44810880
122RPS6KC10.44810880
123ILK0.44522016
124IKBKB0.44442470
125BLK0.42495666
126PRKG20.42159493
127PIM20.41823090
128ROCK10.41669235
129PRKAA20.41625264
130NTRK10.41168898
131KSR10.40303763
132FGFR10.40270688
133ERBB20.39882919
134ERBB30.39357882
135PDK10.39002855
136MAP3K80.38813308
137SGK30.37336694
138FGFR40.37202037
139MAPK120.35510527
140MAPK40.34429716

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.68569160
2Lysosome_Homo sapiens_hsa041423.29710764
3Other glycan degradation_Homo sapiens_hsa005112.74246074
4Staphylococcus aureus infection_Homo sapiens_hsa051502.16836909
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.14771653
6ECM-receptor interaction_Homo sapiens_hsa045121.95883625
7Osteoclast differentiation_Homo sapiens_hsa043801.95549003
8Malaria_Homo sapiens_hsa051441.90649481
9Phagosome_Homo sapiens_hsa041451.84224970
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81327019
11Leishmaniasis_Homo sapiens_hsa051401.79417482
12Asthma_Homo sapiens_hsa053101.75119428
13Focal adhesion_Homo sapiens_hsa045101.73759483
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69304795
15Allograft rejection_Homo sapiens_hsa053301.67583690
16Tuberculosis_Homo sapiens_hsa051521.56085383
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.55599762
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.54606195
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54309981
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52553680
21Graft-versus-host disease_Homo sapiens_hsa053321.51240829
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.46713144
23Amoebiasis_Homo sapiens_hsa051461.45343478
24Chronic myeloid leukemia_Homo sapiens_hsa052201.44496842
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43595453
26Proteoglycans in cancer_Homo sapiens_hsa052051.41121404
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36101855
28Autoimmune thyroid disease_Homo sapiens_hsa053201.32156477
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.30675887
30Rheumatoid arthritis_Homo sapiens_hsa053231.29848996
31Pancreatic cancer_Homo sapiens_hsa052121.29278941
32Adherens junction_Homo sapiens_hsa045201.28164616
33Pertussis_Homo sapiens_hsa051331.27943729
34Toxoplasmosis_Homo sapiens_hsa051451.25377028
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20933641
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.20169268
37Viral myocarditis_Homo sapiens_hsa054161.12441391
38Small cell lung cancer_Homo sapiens_hsa052221.08984131
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08429234
40B cell receptor signaling pathway_Homo sapiens_hsa046621.06307908
41Salmonella infection_Homo sapiens_hsa051321.03944900
42Type I diabetes mellitus_Homo sapiens_hsa049401.03209539
43Platelet activation_Homo sapiens_hsa046111.03053212
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02524307
45Protein digestion and absorption_Homo sapiens_hsa049741.02386214
46Shigellosis_Homo sapiens_hsa051311.00186995
47TNF signaling pathway_Homo sapiens_hsa046680.98046426
48Renal cell carcinoma_Homo sapiens_hsa052110.97762984
49PPAR signaling pathway_Homo sapiens_hsa033200.97394636
50Glioma_Homo sapiens_hsa052140.96800851
51Apoptosis_Homo sapiens_hsa042100.95432243
52Melanoma_Homo sapiens_hsa052180.95001242
53Galactose metabolism_Homo sapiens_hsa000520.94682583
54Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94045517
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92472372
56Sphingolipid metabolism_Homo sapiens_hsa006000.92318617
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92163916
58MicroRNAs in cancer_Homo sapiens_hsa052060.92106718
59Colorectal cancer_Homo sapiens_hsa052100.91649779
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90576534
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.90388762
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89679700
63Mineral absorption_Homo sapiens_hsa049780.89650847
64Renin-angiotensin system_Homo sapiens_hsa046140.89428895
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.88016766
66Prostate cancer_Homo sapiens_hsa052150.85952442
67Caffeine metabolism_Homo sapiens_hsa002320.84675484
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.82226236
69Complement and coagulation cascades_Homo sapiens_hsa046100.81043180
70African trypanosomiasis_Homo sapiens_hsa051430.81024476
71Endocytosis_Homo sapiens_hsa041440.80667013
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.80402675
73TGF-beta signaling pathway_Homo sapiens_hsa043500.80120987
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.79411019
75Prion diseases_Homo sapiens_hsa050200.78309341
76Hepatitis B_Homo sapiens_hsa051610.78035820
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77358807
78Legionellosis_Homo sapiens_hsa051340.76605160
79Herpes simplex infection_Homo sapiens_hsa051680.74550666
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73711910
81mTOR signaling pathway_Homo sapiens_hsa041500.73200216
82HIF-1 signaling pathway_Homo sapiens_hsa040660.73154368
83VEGF signaling pathway_Homo sapiens_hsa043700.70976336
84Insulin resistance_Homo sapiens_hsa049310.70585792
85Endometrial cancer_Homo sapiens_hsa052130.69146549
86Choline metabolism in cancer_Homo sapiens_hsa052310.66660522
87Rap1 signaling pathway_Homo sapiens_hsa040150.66549762
88Chemokine signaling pathway_Homo sapiens_hsa040620.66266480
89Collecting duct acid secretion_Homo sapiens_hsa049660.66128020
90Measles_Homo sapiens_hsa051620.65310949
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.65256004
92Antigen processing and presentation_Homo sapiens_hsa046120.63546659
93Acute myeloid leukemia_Homo sapiens_hsa052210.62547150
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.61947457
95Type II diabetes mellitus_Homo sapiens_hsa049300.61020186
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.60518958
97Notch signaling pathway_Homo sapiens_hsa043300.59830408
98Non-small cell lung cancer_Homo sapiens_hsa052230.58843239
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58579120
100Pathways in cancer_Homo sapiens_hsa052000.56630756
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55221850
102Axon guidance_Homo sapiens_hsa043600.54864023
103Prolactin signaling pathway_Homo sapiens_hsa049170.53798585
104Vibrio cholerae infection_Homo sapiens_hsa051100.52943144
105Steroid biosynthesis_Homo sapiens_hsa001000.52594026
106Ras signaling pathway_Homo sapiens_hsa040140.52022886
107Influenza A_Homo sapiens_hsa051640.50866548
108Hepatitis C_Homo sapiens_hsa051600.50655912
109Hematopoietic cell lineage_Homo sapiens_hsa046400.49763186
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49111066
111Bladder cancer_Homo sapiens_hsa052190.48987228
112Sulfur metabolism_Homo sapiens_hsa009200.48904391
113Glycerolipid metabolism_Homo sapiens_hsa005610.47440228
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47127797
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.43802598
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39647155
117Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37737131
118T cell receptor signaling pathway_Homo sapiens_hsa046600.33200856
119HTLV-I infection_Homo sapiens_hsa051660.32118552
120Epstein-Barr virus infection_Homo sapiens_hsa051690.30103692
121Fructose and mannose metabolism_Homo sapiens_hsa000510.29969764
122GnRH signaling pathway_Homo sapiens_hsa049120.29962697
123Viral carcinogenesis_Homo sapiens_hsa052030.26175532
124Systemic lupus erythematosus_Homo sapiens_hsa053220.25392467

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