LGALS8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.13816981
2L-phenylalanine catabolic process (GO:0006559)6.13816981
3L-phenylalanine metabolic process (GO:0006558)5.88358725
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.88358725
5aromatic amino acid family catabolic process (GO:0009074)5.62410771
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.34709123
7tryptophan catabolic process (GO:0006569)5.19374109
8indole-containing compound catabolic process (GO:0042436)5.19374109
9indolalkylamine catabolic process (GO:0046218)5.19374109
10tryptophan metabolic process (GO:0006568)4.97732239
11kynurenine metabolic process (GO:0070189)4.96024551
12urea cycle (GO:0000050)4.89396776
13urea metabolic process (GO:0019627)4.89396776
14bile acid biosynthetic process (GO:0006699)4.88863387
15peptidyl-glutamic acid carboxylation (GO:0017187)4.85916175
16protein carboxylation (GO:0018214)4.85916175
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82308732
18complement activation, alternative pathway (GO:0006957)4.82244782
19regulation of protein activation cascade (GO:2000257)4.79179855
20alpha-linolenic acid metabolic process (GO:0036109)4.78789276
21positive regulation of gamma-delta T cell activation (GO:0046645)4.77545336
22high-density lipoprotein particle remodeling (GO:0034375)4.58260026
23glyoxylate metabolic process (GO:0046487)4.58056594
24regulation of complement activation (GO:0030449)4.54775384
25nitrogen cycle metabolic process (GO:0071941)4.48634038
26negative regulation of fibrinolysis (GO:0051918)4.47650321
27sulfur amino acid catabolic process (GO:0000098)4.47514550
28cysteine metabolic process (GO:0006534)4.45557685
29regulation of triglyceride catabolic process (GO:0010896)4.33533972
30regulation of fibrinolysis (GO:0051917)4.25538793
31phospholipid efflux (GO:0033700)4.25139685
32homocysteine metabolic process (GO:0050667)4.22489035
33aromatic amino acid family metabolic process (GO:0009072)4.19952727
34bile acid metabolic process (GO:0008206)4.18663041
35amino-acid betaine metabolic process (GO:0006577)4.16036064
36regulation of cholesterol esterification (GO:0010872)4.14876996
37reverse cholesterol transport (GO:0043691)4.12159676
38plasma lipoprotein particle clearance (GO:0034381)4.05507536
39tyrosine metabolic process (GO:0006570)4.03801856
40plasma lipoprotein particle remodeling (GO:0034369)4.03418900
41protein-lipid complex remodeling (GO:0034368)4.03418900
42macromolecular complex remodeling (GO:0034367)4.03418900
43serine family amino acid catabolic process (GO:0009071)4.02957634
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95537247
45cholesterol efflux (GO:0033344)3.85552152
46bile acid and bile salt transport (GO:0015721)3.82266282
47negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.78371966
48negative regulation of cell killing (GO:0031342)3.78371966
49acylglycerol homeostasis (GO:0055090)3.76612203
50triglyceride homeostasis (GO:0070328)3.76612203
51lysine catabolic process (GO:0006554)3.76609481
52lysine metabolic process (GO:0006553)3.76609481
53indolalkylamine metabolic process (GO:0006586)3.76509596
54regulation of gamma-delta T cell differentiation (GO:0045586)3.73346472
55negative regulation of cholesterol transport (GO:0032375)3.71655115
56negative regulation of sterol transport (GO:0032372)3.71655115
57regulation of gamma-delta T cell activation (GO:0046643)3.70895349
58neutrophil activation involved in immune response (GO:0002283)3.68659018
59alpha-amino acid catabolic process (GO:1901606)3.66803097
60coenzyme catabolic process (GO:0009109)3.63398116
61cofactor catabolic process (GO:0051187)3.58387137
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.58333587
63phospholipid homeostasis (GO:0055091)3.53034025
64cellular glucuronidation (GO:0052695)3.52850152
65fibrinolysis (GO:0042730)3.50997405
66cellular biogenic amine catabolic process (GO:0042402)3.50421960
67amine catabolic process (GO:0009310)3.50421960
68antigen processing and presentation of endogenous antigen (GO:0019883)3.49237320
69benzene-containing compound metabolic process (GO:0042537)3.49162035
70positive regulation of lipoprotein lipase activity (GO:0051006)3.48678080
71positive regulation of triglyceride lipase activity (GO:0061365)3.48678080
72regulation of B cell receptor signaling pathway (GO:0050855)3.48313549
73plasma lipoprotein particle assembly (GO:0034377)3.47593550
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.47315773
75aldehyde catabolic process (GO:0046185)3.43915027
76low-density lipoprotein particle remodeling (GO:0034374)3.42066674
77complement activation, classical pathway (GO:0006958)3.41316795
78complement activation (GO:0006956)3.38963579
79positive regulation of lipid catabolic process (GO:0050996)3.38354713
80cellular amino acid catabolic process (GO:0009063)3.37504989
81acute-phase response (GO:0006953)3.36255581
82arginine metabolic process (GO:0006525)3.35039234
83opsonization (GO:0008228)3.34158751
84NAD biosynthetic process (GO:0009435)3.32118882
85positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.32073381
86drug catabolic process (GO:0042737)3.29633680
87protein activation cascade (GO:0072376)3.29454506
88pyridine nucleotide biosynthetic process (GO:0019363)3.28377544
89nicotinamide nucleotide biosynthetic process (GO:0019359)3.28377544
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27191372
91cellular ketone body metabolic process (GO:0046950)3.25524733
92positive regulation of granulocyte differentiation (GO:0030854)3.23925676
93cholesterol homeostasis (GO:0042632)3.23815720
94uronic acid metabolic process (GO:0006063)3.23210693
95glucuronate metabolic process (GO:0019585)3.23210693
96urate metabolic process (GO:0046415)3.22116768
97protein-lipid complex assembly (GO:0065005)3.22036125
98dicarboxylic acid biosynthetic process (GO:0043650)3.21387875
99sterol homeostasis (GO:0055092)3.20102879
100plasma lipoprotein particle organization (GO:0071827)3.19644133
101ethanol oxidation (GO:0006069)3.19570895
102negative T cell selection (GO:0043383)3.19256979
103tolerance induction (GO:0002507)3.19251136
104cellular modified amino acid catabolic process (GO:0042219)3.18704736
105very-low-density lipoprotein particle assembly (GO:0034379)3.17882566
106carnitine metabolic process (GO:0009437)3.16228507
107serine family amino acid metabolic process (GO:0009069)3.15693505
108negative thymic T cell selection (GO:0045060)3.15097278
109regulation of cholesterol homeostasis (GO:2000188)3.13107126
110glycine metabolic process (GO:0006544)3.12866205
111negative regulation of erythrocyte differentiation (GO:0045647)3.12775502
112lipoprotein metabolic process (GO:0042157)3.12308202
113carboxylic acid catabolic process (GO:0046395)3.10837398
114organic acid catabolic process (GO:0016054)3.10837398
115glutamate metabolic process (GO:0006536)3.10691786
116cellular extravasation (GO:0045123)3.08373962
117regulation of regulatory T cell differentiation (GO:0045589)3.07554114
118response to interleukin-15 (GO:0070672)3.06838600
119valine metabolic process (GO:0006573)3.06761838
120protein-lipid complex subunit organization (GO:0071825)3.06607526
121regulation of tolerance induction (GO:0002643)2.98217526
122detection of other organism (GO:0098543)2.97169711
123response to peptidoglycan (GO:0032494)2.88574798
124definitive hemopoiesis (GO:0060216)2.82941858
125detection of bacterium (GO:0016045)2.81249848
126positive regulation of B cell differentiation (GO:0045579)2.81172984
127positive regulation of tolerance induction (GO:0002645)2.79060561
128negative regulation of T cell mediated immunity (GO:0002710)2.77959429
129immunoglobulin mediated immune response (GO:0016064)2.76054513
130regulation of T cell tolerance induction (GO:0002664)2.75994856
131T cell migration (GO:0072678)2.73477795
132neutrophil activation (GO:0042119)2.72654013
133regulation of mast cell degranulation (GO:0043304)2.70458616
134negative regulation of lymphocyte mediated immunity (GO:0002707)2.69109887
135positive thymic T cell selection (GO:0045059)2.68047962
136granulocyte activation (GO:0036230)2.62775433
137positive regulation of mast cell activation (GO:0033005)2.62300824
138detection of external biotic stimulus (GO:0098581)2.60161427
139modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.58301726
140positive regulation by organism of defense response of other organism involved in symbiotic interact2.58301726
141modulation by symbiont of host immune response (GO:0052553)2.58301726
142positive regulation by symbiont of host defense response (GO:0052509)2.58301726
143modulation by symbiont of host defense response (GO:0052031)2.58301726
144modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.58301726
145negative regulation of interleukin-12 production (GO:0032695)2.58241891
146cellular response to ethanol (GO:0071361)2.56978752
147regulation of mast cell activation involved in immune response (GO:0033006)2.56641602
148positive T cell selection (GO:0043368)2.54266633
149detection of molecule of bacterial origin (GO:0032490)2.52991772
150hypotonic response (GO:0006971)2.52288314
151regulation of hypersensitivity (GO:0002883)2.51348343
152regulation of granulocyte differentiation (GO:0030852)2.51055790
153myeloid cell activation involved in immune response (GO:0002275)2.50894818
154leukocyte aggregation (GO:0070486)2.50866241
155B cell receptor signaling pathway (GO:0050853)2.50793533
156T cell selection (GO:0045058)2.50206130
157regulation of myeloid leukocyte mediated immunity (GO:0002886)2.49603068
158response to type I interferon (GO:0034340)2.47251364
159cellular response to interleukin-15 (GO:0071350)2.47018421
160negative regulation of leukocyte mediated immunity (GO:0002704)2.46663803
161regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.45303723
162regulation of macrophage chemotaxis (GO:0010758)2.45162375
163negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.44754449
164negative regulation of T-helper cell differentiation (GO:0045623)2.44754449
165germinal center formation (GO:0002467)2.44450327
166type I interferon signaling pathway (GO:0060337)2.44397315
167cellular response to type I interferon (GO:0071357)2.44397315
168regulation of alpha-beta T cell proliferation (GO:0046640)2.42879075
169negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.42313386
170regulation of germinal center formation (GO:0002634)2.42004593
171regulation of mast cell activation (GO:0033003)2.41942032
172thymic T cell selection (GO:0045061)2.41345315
173regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.40938549
174positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40542246
175response to muramyl dipeptide (GO:0032495)2.40293387
176pinocytosis (GO:0006907)2.39222920
177negative regulation of humoral immune response (GO:0002921)2.39074967
178positive regulation of macrophage differentiation (GO:0045651)2.37968947
179lipopolysaccharide-mediated signaling pathway (GO:0031663)2.37529873
180regulation of leukocyte degranulation (GO:0043300)2.37384277
181macrophage activation involved in immune response (GO:0002281)2.37143292
182mast cell activation (GO:0045576)2.35929909
183regulation of B cell differentiation (GO:0045577)2.35502148
184cellular response to thyroid hormone stimulus (GO:0097067)2.34425209
185negative regulation of cytokine production involved in immune response (GO:0002719)2.33936288
186positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.32420012
187Arp2/3 complex-mediated actin nucleation (GO:0034314)2.31040891
188leukocyte degranulation (GO:0043299)2.30948139
189positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.30210033
190negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.29895432
191interferon-gamma-mediated signaling pathway (GO:0060333)2.28855445
192positive regulation of mast cell degranulation (GO:0043306)2.28474270
193positive regulation of mast cell activation involved in immune response (GO:0033008)2.28474270
194negative regulation of granulocyte differentiation (GO:0030853)2.26492332
195negative regulation of complement activation (GO:0045916)2.26000649
196hepatocyte apoptotic process (GO:0097284)2.25813119
197negative regulation of innate immune response (GO:0045824)2.25625022
198JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.25376704
199negative regulation of adaptive immune response (GO:0002820)2.25351025
200regulation of natural killer cell mediated immunity (GO:0002715)2.25267356

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.10265527
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.52343532
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.66881273
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.63676829
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.14734975
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.16563592
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.08511877
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.06398550
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.91183759
10* IRF8_22096565_ChIP-ChIP_GC-B_Human3.84289267
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.11019655
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.94643397
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.73133466
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.42029735
15SCL_19346495_ChIP-Seq_HPC-7_Human2.38894234
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.19103045
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.16386882
18GATA1_22025678_ChIP-Seq_K562_Human2.11902805
19TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08894314
20MYB_26560356_Chip-Seq_TH2_Human2.07591954
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.02791840
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.97126599
23* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95904053
24* IRF8_27001747_Chip-Seq_BMDM_Mouse1.90902513
25SPI1_23127762_ChIP-Seq_K562_Human1.90328678
26* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77297771
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74278284
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74191537
29MYB_26560356_Chip-Seq_TH1_Human1.70182955
30VDR_24763502_ChIP-Seq_THP-1_Human1.65330515
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.64175257
32HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.59538264
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.58288782
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.57885483
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.54014287
36* GATA3_27048872_Chip-Seq_THYMUS_Human1.51448947
37* MAF_26560356_Chip-Seq_TH1_Human1.51126035
38SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50456055
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50382612
40THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48065684
41SPI1_23547873_ChIP-Seq_NB4_Human1.47618920
42* ESR1_20079471_ChIP-ChIP_T-47D_Human1.47233618
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44725734
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44459610
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43752079
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39938759
47CLOCK_20551151_ChIP-Seq_293T_Human1.36434101
48UTX_26944678_Chip-Seq_JUKART_Human1.30933654
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29665964
50GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29294481
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28744849
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24646618
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23958238
54* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23660621
55* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.20912980
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19359197
57TCF7_22412390_ChIP-Seq_EML_Mouse1.18310852
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17394642
59HTT_18923047_ChIP-ChIP_STHdh_Human1.12161963
60* HNF4A_19822575_ChIP-Seq_HepG2_Human1.11065798
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.09319981
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09021199
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08296648
64RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06827598
65VDR_21846776_ChIP-Seq_THP-1_Human1.05262241
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02939692
67NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02939692
68KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02216410
69PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00748056
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00577323
71BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97779116
72GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96197447
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.93862173
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92473783
75ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92211759
76* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91435513
77KAP1_22055183_ChIP-Seq_ESCs_Mouse0.91372387
78TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89453391
79MAF_26560356_Chip-Seq_TH2_Human0.88302192
80TP63_17297297_ChIP-ChIP_HaCaT_Human0.87509574
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87370887
82* GATA4_25053715_ChIP-Seq_YYC3_Human0.86633271
83* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85997818
84* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85762378
85* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85762378
86CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84976720
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84420868
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84325046
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82191991
90ESR2_21235772_ChIP-Seq_MCF-7_Human0.81966128
91SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81856678
92STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80885136
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80418217
94PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79719911
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.78499437
96PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.78188372
97PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77841513
98EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.77825886
99* SOX2_20726797_ChIP-Seq_SW620_Human0.77692323
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76240390
101PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75728768
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.75601485
103PU_27001747_Chip-Seq_BMDM_Mouse0.75374094
104STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.73750033
105PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.73627788
106EGR1_19032775_ChIP-ChIP_M12_Human0.73133272
107* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72829520
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.72343790
109GATA2_19941826_ChIP-Seq_K562_Human0.72134460
110VDR_24787735_ChIP-Seq_THP-1_Human0.72042371
111RARA_24833708_ChIP-Seq_LIVER_Mouse0.71836581
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.68929158
113CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.68454125
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.67947388
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.64077135
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.63957997
117RUNX_20019798_ChIP-Seq_JUKART_Human0.63858966
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63415697
119STAT1_17558387_ChIP-Seq_HELA_Human0.62765685
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.62248080
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62189464
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.62168676
123SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.62115110
124CJUN_26792858_Chip-Seq_BT549_Human0.61694429
125* GATA3_26560356_Chip-Seq_TH2_Human0.61682152
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61584554
127BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.61508959
128* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.60978317
129GATA1_19941826_ChIP-Seq_K562_Human0.60846293
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.60228087
131ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.59961694
132BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59331426
133AR_20517297_ChIP-Seq_VCAP_Human0.59130190
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.58801114
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.57861841
136* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57490607
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.57248250
138* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.57029736

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.56068123
2MP0005360_urolithiasis6.07901369
3MP0005085_abnormal_gallbladder_physiolo5.01711546
4MP0005365_abnormal_bile_salt4.92944703
5MP0008875_abnormal_xenobiotic_pharmacok4.12095924
6MP0009840_abnormal_foam_cell3.47202478
7MP0003806_abnormal_nucleotide_metabolis3.22691141
8MP0003252_abnormal_bile_duct3.13376055
9MP0010329_abnormal_lipoprotein_level3.00542849
10MP0003191_abnormal_cellular_cholesterol2.67630317
11MP0003195_calcinosis2.57107709
12MP0005083_abnormal_biliary_tract2.49575352
13MP0003763_abnormal_thymus_physiology2.46316659
14MP0005332_abnormal_amino_acid2.45170512
15MP0000465_gastrointestinal_hemorrhage2.31362414
16MP0001666_abnormal_nutrient_absorption2.07266868
17MP0000609_abnormal_liver_physiology2.05280308
18MP0004019_abnormal_vitamin_homeostasis1.97030129
19MP0002420_abnormal_adaptive_immunity1.91177873
20MP0002118_abnormal_lipid_homeostasis1.89228138
21MP0002138_abnormal_hepatobiliary_system1.83658220
22MP0003724_increased_susceptibility_to1.83616594
23MP0005058_abnormal_lysosome_morphology1.83174474
24MP0005319_abnormal_enzyme/_coenzyme1.79739505
25MP0003828_pulmonary_edema1.76124112
26MP0002405_respiratory_system_inflammati1.73946459
27MP0001835_abnormal_antigen_presentation1.61423969
28MP0009764_decreased_sensitivity_to1.60520826
29MP0001764_abnormal_homeostasis1.57287564
30MP0003436_decreased_susceptibility_to1.56670529
31MP0003656_abnormal_erythrocyte_physiolo1.53482161
32MP0002398_abnormal_bone_marrow1.53336743
33MP0003868_abnormal_feces_composition1.51898516
34MP0006082_CNS_inflammation1.51759089
35MP0005584_abnormal_enzyme/coenzyme_acti1.51249240
36MP0009697_abnormal_copulation1.48687500
37MP0000716_abnormal_immune_system1.48016658
38MP0009785_altered_susceptibility_to1.47546379
39MP0002132_abnormal_respiratory_system1.46804870
40MP0008469_abnormal_protein_level1.45152027
41MP0000604_amyloidosis1.43351394
42MP0008004_abnormal_stomach_pH1.42844332
43MP0003866_abnormal_defecation1.42826261
44MP0009333_abnormal_splenocyte_physiolog1.40764829
45MP0001851_eye_inflammation1.38987953
46MP0001545_abnormal_hematopoietic_system1.37102205
47MP0005397_hematopoietic_system_phenotyp1.37102205
48MP0009643_abnormal_urine_homeostasis1.36609402
49MP0003186_abnormal_redox_activity1.35972035
50MP0000689_abnormal_spleen_morphology1.34291264
51MP0001873_stomach_inflammation1.32267315
52MP0000858_altered_metastatic_potential1.30242948
53MP0005409_darkened_coat_color1.28260474
54MP0002722_abnormal_immune_system1.25691698
55MP0003011_delayed_dark_adaptation1.25153406
56MP0005464_abnormal_platelet_physiology1.24877796
57MP0002419_abnormal_innate_immunity1.23243517
58MP0009763_increased_sensitivity_to1.22262798
59MP0000598_abnormal_liver_morphology1.19273594
60MP0002429_abnormal_blood_cell1.18535191
61MP0002396_abnormal_hematopoietic_system1.15027626
62MP0004381_abnormal_hair_follicle1.13895445
63MP0002254_reproductive_system_inflammat1.11809606
64MP0004883_abnormal_blood_vessel1.11484822
65MP0002933_joint_inflammation1.10389118
66MP0005451_abnormal_body_composition1.08003706
67MP0005025_abnormal_response_to1.07871920
68MP0000703_abnormal_thymus_morphology1.04803344
69MP0003045_fibrosis1.04287373
70MP0004130_abnormal_muscle_cell1.04228258
71MP0002009_preneoplasia1.01525218
72MP0005670_abnormal_white_adipose1.01511617
73MP0009278_abnormal_bone_marrow1.01120894
74MP0002006_tumorigenesis0.99336017
75MP0005636_abnormal_mineral_homeostasis0.98730364
76MP0001845_abnormal_inflammatory_respons0.97669419
77MP0003690_abnormal_glial_cell0.96791743
78MP0004808_abnormal_hematopoietic_stem0.96641874
79MP0005647_abnormal_sex_gland0.96040218
80MP0001790_abnormal_immune_system0.94268427
81MP0005387_immune_system_phenotype0.94268427
82MP0001533_abnormal_skeleton_physiology0.93676184
83MP0004510_myositis0.92812665
84MP0009642_abnormal_blood_homeostasis0.92647382
85MP0010368_abnormal_lymphatic_system0.92113810
86MP0000685_abnormal_immune_system0.91787583
87MP0001756_abnormal_urination0.90994234
88MP0005165_increased_susceptibility_to0.89918841
89MP0003300_gastrointestinal_ulcer0.89015713
90MP0005310_abnormal_salivary_gland0.86767221
91MP0004947_skin_inflammation0.85527506
92MP0005666_abnormal_adipose_tissue0.85405848
93MP0003453_abnormal_keratinocyte_physiol0.84797442
94MP0003172_abnormal_lysosome_physiology0.84233430
95MP0003448_altered_tumor_morphology0.83994251
96MP0005408_hypopigmentation0.83896751
97MP0008438_abnormal_cutaneous_collagen0.83561887
98MP0005000_abnormal_immune_tolerance0.83113879
99MP0002876_abnormal_thyroid_physiology0.81850910
100MP0003705_abnormal_hypodermis_morpholog0.81287477
101MP0001800_abnormal_humoral_immune0.81219036
102MP0004484_altered_response_of0.80589305
103MP0002148_abnormal_hypersensitivity_rea0.80336124
104MP0002723_abnormal_immune_serum0.78073828
105MP0009765_abnormal_xenobiotic_induced0.77758663
106MP0001853_heart_inflammation0.77548478
107MP0005166_decreased_susceptibility_to0.77262944
108MP0002136_abnormal_kidney_physiology0.76987338
109MP0003950_abnormal_plasma_membrane0.75736869
110MP0002166_altered_tumor_susceptibility0.75605425
111MP0005334_abnormal_fat_pad0.75601172
112MP0008260_abnormal_autophagy0.75541422
113MP0003075_altered_response_to0.73625553
114MP0002971_abnormal_brown_adipose0.72104041
115MP0005671_abnormal_response_to0.71963356
116MP0001661_extended_life_span0.71896932
117MP0002452_abnormal_antigen_presenting0.71819287
118MP0003303_peritoneal_inflammation0.71566952
119MP0002078_abnormal_glucose_homeostasis0.70805188
120MP0006036_abnormal_mitochondrial_physio0.69738495
121MP0005376_homeostasis/metabolism_phenot0.68627649
122MP0005410_abnormal_fertilization0.68616860
123MP0001542_abnormal_bone_strength0.67974963
124MP0000249_abnormal_blood_vessel0.66446735
125MP0005535_abnormal_body_temperature0.66181843
126MP0005164_abnormal_response_to0.63660625
127MP0004782_abnormal_surfactant_physiolog0.62235396
128MP0010155_abnormal_intestine_physiology0.58797106
129MP0000343_altered_response_to0.56881903
130MP0005023_abnormal_wound_healing0.56405079
131MP0009115_abnormal_fat_cell0.56282130
132MP0002998_abnormal_bone_remodeling0.54802642
133MP0008873_increased_physiological_sensi0.54211403
134MP0002168_other_aberrant_phenotype0.53703670
135MP0003183_abnormal_peptide_metabolism0.53681309
136MP0005084_abnormal_gallbladder_morpholo0.50689856
137MP0001819_abnormal_immune_cell0.48982705
138MP0002060_abnormal_skin_morphology0.48950370

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.16002041
2Deep venous thrombosis (HP:0002625)5.75485376
3Intrahepatic cholestasis (HP:0001406)5.62875480
4Xanthomatosis (HP:0000991)5.55391207
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.41605880
6Prolonged partial thromboplastin time (HP:0003645)5.32467248
7Complement deficiency (HP:0004431)5.02450927
8Hyperlipoproteinemia (HP:0010980)4.85925984
9Hypobetalipoproteinemia (HP:0003563)4.77015372
10Prolonged bleeding time (HP:0003010)4.43119752
11Joint hemorrhage (HP:0005261)4.37167361
12Abnormality of the common coagulation pathway (HP:0010990)3.94917452
13Abnormality of glutamine family amino acid metabolism (HP:0010902)3.90461551
14Hypolipoproteinemia (HP:0010981)3.85561837
15Epidermoid cyst (HP:0200040)3.84173918
16Elevated erythrocyte sedimentation rate (HP:0003565)3.77618660
17Abnormality of complement system (HP:0005339)3.76431038
18Hyperammonemia (HP:0001987)3.73809213
19Systemic lupus erythematosus (HP:0002725)3.72722961
20Myositis (HP:0100614)3.69903571
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.67410933
22Hyperglycinemia (HP:0002154)3.67248581
23Hypoalphalipoproteinemia (HP:0003233)3.64817723
24Recurrent gram-negative bacterial infections (HP:0005420)3.56402286
25Recurrent abscess formation (HP:0002722)3.52245264
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.50939692
27Fat malabsorption (HP:0002630)3.47390977
28Hypercholesterolemia (HP:0003124)3.41330282
29Ketosis (HP:0001946)3.38981679
30Abnormality of methionine metabolism (HP:0010901)3.37814136
31Myocardial infarction (HP:0001658)3.37008479
32Abnormality of macrophages (HP:0004311)3.36971442
33Stomatitis (HP:0010280)3.34134876
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.33598228
35Abnormality of the intrinsic pathway (HP:0010989)3.32765350
36Pustule (HP:0200039)3.27367037
37Hyperglycinuria (HP:0003108)3.22908100
38Abnormality of glycine metabolism (HP:0010895)3.20913908
39Abnormality of serine family amino acid metabolism (HP:0010894)3.20913908
40Conjugated hyperbilirubinemia (HP:0002908)3.20749392
41T lymphocytopenia (HP:0005403)3.16990626
42Abnormality of fatty-acid metabolism (HP:0004359)3.16290060
43Hypoglycemic coma (HP:0001325)3.14727991
44Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.13562423
45Recurrent fungal infections (HP:0002841)3.11805317
46Abnormality of T cell number (HP:0011839)3.04123367
47Autoimmune hemolytic anemia (HP:0001890)3.03475394
48Orchitis (HP:0100796)3.02909073
49Increased IgE level (HP:0003212)3.02333779
50Spontaneous abortion (HP:0005268)2.98621267
51Spontaneous hematomas (HP:0007420)2.92806506
52Retrobulbar optic neuritis (HP:0100654)2.87449177
53Optic neuritis (HP:0100653)2.87449177
54Glomerulonephritis (HP:0000099)2.87145512
55Abnormality of pyrimidine metabolism (HP:0004353)2.85919676
56Gastrointestinal infarctions (HP:0005244)2.85422369
57Petechiae (HP:0000967)2.80292617
58Abnormality of nucleobase metabolism (HP:0010932)2.78314166
59Dysostosis multiplex (HP:0000943)2.77307048
60Mitral stenosis (HP:0001718)2.77139028
61Gingival bleeding (HP:0000225)2.74587337
62Abnormality of purine metabolism (HP:0004352)2.74511411
63Chronic obstructive pulmonary disease (HP:0006510)2.69901722
64Obstructive lung disease (HP:0006536)2.69901722
65Keratoconjunctivitis sicca (HP:0001097)2.67947259
66Abnormal delayed hypersensitivity skin test (HP:0002963)2.67098002
67Hyperbilirubinemia (HP:0002904)2.65613076
68Recurrent skin infections (HP:0001581)2.64847698
69Steatorrhea (HP:0002570)2.64236708
70Vasculitis (HP:0002633)2.62604583
71Abnormality of serum amino acid levels (HP:0003112)2.60083503
72Mediastinal lymphadenopathy (HP:0100721)2.55280227
73Skin nodule (HP:0200036)2.53197955
74Vascular calcification (HP:0004934)2.52554785
75Abnormality of liposaccharide metabolism (HP:0010968)2.51534112
76Abnormality of glycosphingolipid metabolism (HP:0004343)2.51534112
77Abnormality of glycolipid metabolism (HP:0010969)2.51534112
78Meningitis (HP:0001287)2.51164028
79Abnormality of T cells (HP:0002843)2.49404056
80Recurrent viral infections (HP:0004429)2.48469243
81Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45939264
82Arterial thrombosis (HP:0004420)2.44743916
83Gingivitis (HP:0000230)2.44109901
84Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41543235
85Dicarboxylic aciduria (HP:0003215)2.41543235
86Axonal loss (HP:0003447)2.40910602
87Abnormal platelet volume (HP:0011876)2.40674397
88Pulmonary infiltrates (HP:0002113)2.39904217
89Gout (HP:0001997)2.38651379
90Chronic diarrhea (HP:0002028)2.38402277
91Cardiovascular calcification (HP:0011915)2.37780871
92Papilledema (HP:0001085)2.37050220
93Keratoconjunctivitis (HP:0001096)2.34644532
94Chronic mucocutaneous candidiasis (HP:0002728)2.33164420
95Recurrent cutaneous fungal infections (HP:0011370)2.33164420
96Impaired platelet aggregation (HP:0003540)2.32209738
97Abnormal platelet function (HP:0011869)2.32209738
98Abnormality of proline metabolism (HP:0010907)2.31723434
99Hydroxyprolinuria (HP:0003080)2.31723434
100Recurrent bronchitis (HP:0002837)2.30908338
101Ketoacidosis (HP:0001993)2.29784467
102Inflammation of the large intestine (HP:0002037)2.26473954
103Hepatocellular carcinoma (HP:0001402)2.24274058
104Leukocytosis (HP:0001974)2.24030360
105Autoimmune thrombocytopenia (HP:0001973)2.22792113
106Metabolic acidosis (HP:0001942)2.22192020
107Amyloidosis (HP:0011034)2.20284397
108Increased mean platelet volume (HP:0011877)2.19531634
109Abnormality of iron homeostasis (HP:0011031)2.19113297
110Sensorimotor neuropathy (HP:0007141)2.18753917
111Granulocytopenia (HP:0001913)2.17896637
112Abnormality of T cell physiology (HP:0011840)2.17730129
113Nephritis (HP:0000123)2.16858917
114Acanthocytosis (HP:0001927)2.15734810
115Menorrhagia (HP:0000132)2.15390308
116Chest pain (HP:0100749)2.14483268
117Vacuolated lymphocytes (HP:0001922)2.13514211
118Lethargy (HP:0001254)2.13242148
119Gangrene (HP:0100758)2.11160084
120Mucopolysacchariduria (HP:0008155)2.10383396
121Urinary glycosaminoglycan excretion (HP:0003541)2.10383396
122Gastrointestinal inflammation (HP:0004386)2.09979597
123Pancreatitis (HP:0001733)2.09736840
124Abnormal gallbladder morphology (HP:0012437)2.08645328
125Hemoptysis (HP:0002105)2.08324543
126Irritability (HP:0000737)2.07990688
127Hemorrhage of the eye (HP:0011885)2.07866141
128Generalized aminoaciduria (HP:0002909)2.07262250
129Nausea (HP:0002018)2.06728785
130Esophageal varix (HP:0002040)2.06565607
131Abnormality of transition element cation homeostasis (HP:0011030)2.06140342
132Thrombophlebitis (HP:0004418)2.05823632
133Panhypogammaglobulinemia (HP:0003139)2.05513294
134Eczematoid dermatitis (HP:0000976)2.05491863
135Interstitial pulmonary disease (HP:0006530)2.03339982
136Colitis (HP:0002583)2.03017988
137Opisthotonus (HP:0002179)2.02337270
138Cholelithiasis (HP:0001081)2.01387848
139Abnormality of mucopolysaccharide metabolism (HP:0011020)2.00413606
140Abnormality of polysaccharide metabolism (HP:0011012)2.00413606
141Abnormality of glycosaminoglycan metabolism (HP:0004371)2.00413606
142Delayed CNS myelination (HP:0002188)1.99581707
143Recurrent sinusitis (HP:0011108)1.99560114
144Encephalitis (HP:0002383)1.99530401
145Abnormality of the prostate (HP:0008775)1.99460162
146Tetraparesis (HP:0002273)1.99162772
147Recurrent bacterial skin infections (HP:0005406)1.98184388
148Purpura (HP:0000979)1.94714223
149Eosinophilia (HP:0001880)1.94333973
150Abnormality of B cell number (HP:0010975)1.92150855
151Joint swelling (HP:0001386)1.91989925
152Agammaglobulinemia (HP:0004432)1.91797399
153Hypergammaglobulinemia (HP:0010702)1.89921482
154Neonatal onset (HP:0003623)1.89663121
155Malnutrition (HP:0004395)1.89638885
156Proximal tubulopathy (HP:0000114)1.88661378
157Episodic fever (HP:0001954)1.88373142
158Hyperglycemia (HP:0003074)1.86549009
159Increased serum ferritin (HP:0003281)1.85945379
160Hypoglycemic seizures (HP:0002173)1.85808062
161Increased IgM level (HP:0003496)1.85507180
162Upper motor neuron abnormality (HP:0002127)1.84708825
163Epistaxis (HP:0000421)1.84475659
164Cellulitis (HP:0100658)1.84015716
165Urticaria (HP:0001025)1.83805687
166Spastic diplegia (HP:0001264)1.83431586
167Osteomyelitis (HP:0002754)1.83422787
168Elevated hepatic transaminases (HP:0002910)1.77341525
169Polycythemia (HP:0001901)1.76891175
170Abnormal enzyme/coenzyme activity (HP:0012379)1.75924804
171Alopecia of scalp (HP:0002293)1.75537543
172Abnormal gallbladder physiology (HP:0012438)1.74585029
173Cholecystitis (HP:0001082)1.74585029
174Pulmonary embolism (HP:0002204)1.74461499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.58549583
2FGFR43.76834148
3BCKDK3.35735875
4TYK23.02131460
5TAOK33.01069995
6TBK12.48452783
7NEK92.41439884
8SIK12.40888033
9MAP3K142.26560406
10MST1R2.16112483
11IRAK32.14198844
12JAK12.11771614
13EPHB12.06767865
14EPHA31.99447900
15TGFBR21.94905128
16KIT1.86589316
17PDK21.85085250
18FRK1.76268794
19PIK3CG1.74539526
20FES1.74490761
21GRK61.68368522
22IKBKE1.66623017
23PRPF4B1.61598804
24BMPR21.59319745
25PDK31.56128065
26PDK41.56128065
27FLT31.50730488
28JAK31.45472618
29MAP4K11.44568063
30PIM21.42486470
31ERBB41.38486278
32INSRR1.31537658
33SIK31.27179055
34JAK21.25876451
35IRAK41.23871291
36IRAK11.23587334
37FGFR31.19131693
38HIPK21.18567704
39ZAP701.17753988
40MAP2K31.14209662
41MAPK111.13684676
42MAPKAPK31.12807871
43BLK1.10720802
44TNK21.10116075
45PTK61.09736716
46KDR1.08595844
47ABL21.05222599
48MAPK151.05169511
49CSK0.97840121
50IKBKB0.94807060
51CSF1R0.94714393
52MAP3K60.92117950
53MAP3K70.89233744
54STK380.87328716
55MAP3K30.87239582
56CAMK1D0.87219457
57MST40.86754874
58MAP3K130.83716712
59PRKAA20.82549135
60PIK3CA0.81097850
61PINK10.80903782
62TXK0.79543782
63SCYL20.79360512
64KSR20.79008885
65MATK0.78220773
66MAP3K120.76654713
67MAPK70.73028325
68TRIB30.72806281
69TIE10.70026504
70MAPK40.69550846
71ARAF0.68934275
72GRK70.67595657
73RET0.67559801
74RIPK40.66634118
75BTK0.66402428
76MARK20.66260952
77MAP2K10.65918105
78PDGFRB0.65572038
79MAP4K20.65358105
80CHUK0.63391709
81SYK0.63154076
82SGK30.62815926
83CAMKK20.62205335
84CDC42BPA0.61592965
85CAMKK10.61459092
86CDK120.60902014
87MAP2K40.60544258
88STK30.60048123
89MAP2K60.59484786
90TESK20.59244921
91NUAK10.58411972
92PTK2B0.57438502
93ITK0.57091849
94YES10.57085032
95WNK10.56996439
96GSK3A0.56569677
97DYRK1B0.56382348
98IGF1R0.56117363
99PRKCQ0.55919873
100MYLK0.55834361
101MAP3K10.55758537
102PDPK10.55679710
103NEK60.54240976
104TRPM70.54119673
105IRAK20.54064777
106MAP3K20.53282622
107SIK20.52996330
108FGR0.52064038
109MAPK120.51968474
110LYN0.51575023
111TEC0.51527335
112HCK0.51235309
113AKT30.50533433
114LCK0.49464060
115PDK10.48595242
116FYN0.48354519
117GRK50.46615393
118PKN20.46317429
119MARK30.44083009
120LATS10.44069676
121MAP2K20.43963190
122CAMK2G0.42987091
123PRKACG0.42379001
124PRKD20.42218921
125MET0.41369661
126PRKAA10.41070444
127MAP3K50.40635043
128PRKCD0.40418555
129SGK20.39484753
130PRKG20.39016253
131ABL10.38908526
132STK100.38510263
133NLK0.38024752
134PIM10.36581021
135RIPK10.36239475
136ERBB20.36150679
137TTN0.35774369
138CDK60.35763538
139FER0.35707587

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.19563555
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07195296
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.03359903
4Complement and coagulation cascades_Homo sapiens_hsa046102.89088991
5Nitrogen metabolism_Homo sapiens_hsa009102.88189106
6Arginine biosynthesis_Homo sapiens_hsa002202.78563816
7Tryptophan metabolism_Homo sapiens_hsa003802.50264956
8Fatty acid degradation_Homo sapiens_hsa000712.47869583
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.38769606
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.38322093
11Staphylococcus aureus infection_Homo sapiens_hsa051502.35483085
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26106924
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.18843843
14Caffeine metabolism_Homo sapiens_hsa002322.17136732
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16083551
16Peroxisome_Homo sapiens_hsa041462.07122481
17PPAR signaling pathway_Homo sapiens_hsa033201.95078889
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91620736
19Hematopoietic cell lineage_Homo sapiens_hsa046401.90548095
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.90520370
21Allograft rejection_Homo sapiens_hsa053301.84275517
22Graft-versus-host disease_Homo sapiens_hsa053321.82136709
23Propanoate metabolism_Homo sapiens_hsa006401.80734028
24Primary immunodeficiency_Homo sapiens_hsa053401.79916293
25Histidine metabolism_Homo sapiens_hsa003401.79484443
26Chemical carcinogenesis_Homo sapiens_hsa052041.78281715
27B cell receptor signaling pathway_Homo sapiens_hsa046621.77033607
28Butanoate metabolism_Homo sapiens_hsa006501.73475019
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.73404467
30Fatty acid metabolism_Homo sapiens_hsa012121.72907965
31T cell receptor signaling pathway_Homo sapiens_hsa046601.71488639
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.70920985
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.69550345
34Autoimmune thyroid disease_Homo sapiens_hsa053201.68591744
35Platelet activation_Homo sapiens_hsa046111.60918534
36Vitamin B6 metabolism_Homo sapiens_hsa007501.60240304
37beta-Alanine metabolism_Homo sapiens_hsa004101.53200874
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53005725
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52073870
40Retinol metabolism_Homo sapiens_hsa008301.51335840
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.47396381
42Asthma_Homo sapiens_hsa053101.46729206
43Folate biosynthesis_Homo sapiens_hsa007901.43840529
44Acute myeloid leukemia_Homo sapiens_hsa052211.39785390
45Starch and sucrose metabolism_Homo sapiens_hsa005001.36748663
46ABC transporters_Homo sapiens_hsa020101.34473238
47Sulfur metabolism_Homo sapiens_hsa009201.33744207
48Phenylalanine metabolism_Homo sapiens_hsa003601.31943178
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31884384
50Bile secretion_Homo sapiens_hsa049761.31766746
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29502001
52Selenocompound metabolism_Homo sapiens_hsa004501.29426719
53TNF signaling pathway_Homo sapiens_hsa046681.28118768
54Pyruvate metabolism_Homo sapiens_hsa006201.27535730
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27419678
56Type I diabetes mellitus_Homo sapiens_hsa049401.24827200
57Chemokine signaling pathway_Homo sapiens_hsa040621.24266200
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23291813
59Toxoplasmosis_Homo sapiens_hsa051451.20063704
60Tyrosine metabolism_Homo sapiens_hsa003501.19878045
61Fatty acid elongation_Homo sapiens_hsa000621.14561288
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13720846
63Vitamin digestion and absorption_Homo sapiens_hsa049771.09752933
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08546030
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08433412
66Fat digestion and absorption_Homo sapiens_hsa049751.07726206
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.07141076
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04488578
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01424201
70Carbon metabolism_Homo sapiens_hsa012001.01162544
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00689195
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.99037270
73Steroid biosynthesis_Homo sapiens_hsa001000.98620716
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92143621
75Pancreatic cancer_Homo sapiens_hsa052120.89135151
76Non-small cell lung cancer_Homo sapiens_hsa052230.87471087
77Sulfur relay system_Homo sapiens_hsa041220.87056573
78Biosynthesis of amino acids_Homo sapiens_hsa012300.85921907
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85799638
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.85106489
81Herpes simplex infection_Homo sapiens_hsa051680.84383715
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84125038
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83029160
84Dorso-ventral axis formation_Homo sapiens_hsa043200.82297459
85Pentose phosphate pathway_Homo sapiens_hsa000300.82034812
86Hepatitis B_Homo sapiens_hsa051610.81791774
87Glycerolipid metabolism_Homo sapiens_hsa005610.81082180
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80177185
89Arachidonic acid metabolism_Homo sapiens_hsa005900.80125205
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79465702
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74502875
92Arginine and proline metabolism_Homo sapiens_hsa003300.73013555
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.72492970
94VEGF signaling pathway_Homo sapiens_hsa043700.69856756
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69555790
96Viral myocarditis_Homo sapiens_hsa054160.68084127
97Prolactin signaling pathway_Homo sapiens_hsa049170.67597274
98Chronic myeloid leukemia_Homo sapiens_hsa052200.66569216
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65341058
100Amoebiasis_Homo sapiens_hsa051460.64757780
101Glutathione metabolism_Homo sapiens_hsa004800.64152446
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.63814662
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63617905
104Salmonella infection_Homo sapiens_hsa051320.62593472
105Lysosome_Homo sapiens_hsa041420.61979456
106Renin secretion_Homo sapiens_hsa049240.59817056
107Renal cell carcinoma_Homo sapiens_hsa052110.59743613
108Apoptosis_Homo sapiens_hsa042100.58230332
109Choline metabolism in cancer_Homo sapiens_hsa052310.57643667
110Endocytosis_Homo sapiens_hsa041440.56868512
111Glycosaminoglycan degradation_Homo sapiens_hsa005310.55697818
112Lysine degradation_Homo sapiens_hsa003100.53249624
113Inositol phosphate metabolism_Homo sapiens_hsa005620.52685435
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.51344305
115Fructose and mannose metabolism_Homo sapiens_hsa000510.51262137
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50636445
117Sphingolipid metabolism_Homo sapiens_hsa006000.50124860
118FoxO signaling pathway_Homo sapiens_hsa040680.49413479
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48737401
120Prion diseases_Homo sapiens_hsa050200.48709068
121Fatty acid biosynthesis_Homo sapiens_hsa000610.48434742
122Pancreatic secretion_Homo sapiens_hsa049720.47159804
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45755946
124Shigellosis_Homo sapiens_hsa051310.45166330
125mTOR signaling pathway_Homo sapiens_hsa041500.45058029
126Galactose metabolism_Homo sapiens_hsa000520.44133711
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.41697448
128Metabolic pathways_Homo sapiens_hsa011000.40408258
129Malaria_Homo sapiens_hsa051440.38939927
130Pertussis_Homo sapiens_hsa051330.38317534
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38304461
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.37666869
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.35215477
134Insulin resistance_Homo sapiens_hsa049310.33816900
135Legionellosis_Homo sapiens_hsa051340.33142262
136Leishmaniasis_Homo sapiens_hsa051400.32158218
137Regulation of autophagy_Homo sapiens_hsa041400.30804625
138alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27407729
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.23088876
140Hepatitis C_Homo sapiens_hsa051600.19261591
141Other glycan degradation_Homo sapiens_hsa005110.19116684
142African trypanosomiasis_Homo sapiens_hsa051430.18565074
143Intestinal immune network for IgA production_Homo sapiens_hsa046720.18078463
144Linoleic acid metabolism_Homo sapiens_hsa005910.17383687
145Phagosome_Homo sapiens_hsa041450.17370832
146Rheumatoid arthritis_Homo sapiens_hsa053230.16262241
147Tuberculosis_Homo sapiens_hsa051520.16130721
148One carbon pool by folate_Homo sapiens_hsa006700.15449773
149Measles_Homo sapiens_hsa051620.14171812
150Osteoclast differentiation_Homo sapiens_hsa043800.13797806
151Renin-angiotensin system_Homo sapiens_hsa046140.13618901
152Influenza A_Homo sapiens_hsa051640.11941427
153Antigen processing and presentation_Homo sapiens_hsa046120.10274995
154NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09941912

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