LGALS7B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. Differential and in situ hybridization studies indicate that this lectin is specifically expressed in keratinocytes and found mainly in stratified squamous epithelium. A duplicate copy of this gene (GeneID:3963) is found adjacent to, but on the opposite strand on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epidermal cell differentiation (GO:0009913)8.99705365
2peptide cross-linking (GO:0018149)8.81835010
3water homeostasis (GO:0030104)8.65227608
4intermediate filament organization (GO:0045109)8.44895609
5epidermis development (GO:0008544)8.04084938
6hemidesmosome assembly (GO:0031581)7.53524108
7long-chain fatty acid biosynthetic process (GO:0042759)7.20796175
8linoleic acid metabolic process (GO:0043651)6.83163333
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.64805817
10fatty acid elongation (GO:0030497)6.43410504
11intermediate filament cytoskeleton organization (GO:0045104)5.99398277
12lipoxygenase pathway (GO:0019372)5.93832782
13phosphatidylserine acyl-chain remodeling (GO:0036150)5.86757585
14phosphatidylinositol acyl-chain remodeling (GO:0036149)5.84009505
15intermediate filament-based process (GO:0045103)5.80428990
16skin morphogenesis (GO:0043589)4.79097573
17hair follicle morphogenesis (GO:0031069)4.71316621
18detection of bacterium (GO:0016045)4.68178729
19phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.67884121
20phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.48429176
21keratinocyte development (GO:0003334)4.39315578
22detection of other organism (GO:0098543)4.23153573
23phosphatidylcholine acyl-chain remodeling (GO:0036151)4.20349583
24ectoderm development (GO:0007398)4.02955572
25positive regulation of epidermal cell differentiation (GO:0045606)3.96841770
26establishment of tissue polarity (GO:0007164)3.94738640
27establishment of planar polarity (GO:0001736)3.94738640
28epithelial cell differentiation involved in prostate gland development (GO:0060742)3.86818347
29negative regulation of interferon-gamma production (GO:0032689)3.84515519
30negative regulation of keratinocyte proliferation (GO:0010839)3.82936980
31epithelium development (GO:0060429)3.81950365
32positive regulation of epidermis development (GO:0045684)3.77111356
33phosphatidylserine metabolic process (GO:0006658)3.76890040
34surfactant homeostasis (GO:0043129)3.75459312
35positive regulation of keratinocyte differentiation (GO:0045618)3.70606586
36retinol metabolic process (GO:0042572)3.66257669
37gap junction assembly (GO:0016264)3.62690268
38regulation of keratinocyte differentiation (GO:0045616)3.61812342
39regulation of natural killer cell differentiation (GO:0032823)3.49263586
40lateral sprouting from an epithelium (GO:0060601)3.42139473
41polarized epithelial cell differentiation (GO:0030859)3.37572273
42response to phenylpropanoid (GO:0080184)3.33419393
43ceramide biosynthetic process (GO:0046513)3.29255099
44defense response to fungus (GO:0050832)3.27950399
45chemical homeostasis within a tissue (GO:0048875)3.25623949
46hair cycle process (GO:0022405)3.24267799
47molting cycle process (GO:0022404)3.24267799
48long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.15924712
49very long-chain fatty acid metabolic process (GO:0000038)3.12641176
50phospholipid catabolic process (GO:0009395)3.11590002
51positive regulation of monocyte chemotaxis (GO:0090026)3.11243874
52long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.08640258
53regulation of keratinocyte proliferation (GO:0010837)3.08489451
54alditol phosphate metabolic process (GO:0052646)3.01909365
55keratinization (GO:0031424)21.1646864
56skin development (GO:0043588)2.99100004
57regulation of epidermis development (GO:0045682)2.98180182
58regulation of epidermal cell differentiation (GO:0045604)2.85273202
59positive regulation of chemokine secretion (GO:0090197)2.80211721
60negative regulation of interleukin-17 production (GO:0032700)2.77000643
61regulation of chemokine secretion (GO:0090196)2.76820688
62regulation of transforming growth factor beta1 production (GO:0032908)2.72769490
63hair cell differentiation (GO:0035315)2.69540278
64cell-substrate junction assembly (GO:0007044)2.69262500
65fatty-acyl-CoA biosynthetic process (GO:0046949)2.67174300
66one-carbon compound transport (GO:0019755)2.66120845
67primary alcohol metabolic process (GO:0034308)2.65724990
68planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60525201
69positive regulation of cellular amide metabolic process (GO:0034250)2.59709677
70epithelial cell differentiation (GO:0030855)2.56545497
71fibrinolysis (GO:0042730)2.54571245
72phosphatidylglycerol metabolic process (GO:0046471)2.51701509
73epithelial cell proliferation (GO:0050673)2.49345976
74regulation of neuron projection regeneration (GO:0070570)2.49076261
75regulation of axon regeneration (GO:0048679)2.49076261
76epithelial cell-cell adhesion (GO:0090136)2.47105407
77regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46315349
78ventricular cardiac muscle cell action potential (GO:0086005)2.46035768
79phospholipid efflux (GO:0033700)2.44150463
80unsaturated fatty acid biosynthetic process (GO:0006636)2.42812812
81primary alcohol catabolic process (GO:0034310)2.42063635
82sphingolipid biosynthetic process (GO:0030148)2.41636956
83positive regulation of cholesterol efflux (GO:0010875)2.40888009
84polyol transport (GO:0015791)2.38140246
85fatty-acyl-CoA metabolic process (GO:0035337)2.38062666
86regulation of monocyte chemotaxis (GO:0090025)2.34890050
87cellular response to antibiotic (GO:0071236)2.33942802
88sequestering of metal ion (GO:0051238)2.32108698
89cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.31893028
90atrioventricular valve morphogenesis (GO:0003181)2.29062011
91detection of external biotic stimulus (GO:0098581)2.28883127
92regulation of T cell chemotaxis (GO:0010819)2.27798398
93establishment of skin barrier (GO:0061436)18.8670236
94regulation of water loss via skin (GO:0033561)16.2387924
95desmosome organization (GO:0002934)14.0839659
96hair cycle (GO:0042633)12.2204252
97molting cycle (GO:0042303)12.2204252
98keratinocyte differentiation (GO:0030216)11.2766401
99multicellular organismal water homeostasis (GO:0050891)10.4389835
100keratinocyte proliferation (GO:0043616)10.1899838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.80716558
2* P63_26484246_Chip-Seq_KERATINOCYTES_Human4.28704899
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36697994
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.79697950
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.74969333
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.66879308
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.53467939
8SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.33968838
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.33968838
10ZNF263_19887448_ChIP-Seq_K562_Human2.17081556
11* TP63_23658742_ChIP-Seq_EP156T_Human2.00177770
12TP63_17297297_ChIP-ChIP_HaCaT_Human14.7510665
13TP63_22573176_ChIP-Seq_HFKS_Human1.93045207
14ESR2_21235772_ChIP-Seq_MCF-7_Human1.89298377
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.84234012
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.79035727
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73344526
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.66628268
19RXR_22108803_ChIP-Seq_LS180_Human1.63741517
20GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.52000955
21HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48913237
22BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.47900353
23KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47407778
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.40041662
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33236761
26EGR1_19032775_ChIP-ChIP_M12_Human1.29300535
27UBF1/2_26484160_Chip-Seq_HMECs_Human1.29177197
28RACK7_27058665_Chip-Seq_MCF-7_Human1.28717412
29GATA6_21074721_ChIP-Seq_CACO-2_Human1.28202031
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.27034305
31ATF3_27146783_Chip-Seq_COLON_Human1.26263236
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24342033
33KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22561454
34KLF5_25053715_ChIP-Seq_YYC3_Human1.21349410
35ERG_20517297_ChIP-Seq_VCAP_Human1.21321089
36RUNX1_27514584_Chip-Seq_MCF-7_Human1.19723623
37GATA3_24758297_ChIP-Seq_MCF-7_Human1.19346563
38SOX2_20726797_ChIP-Seq_SW620_Human1.17422461
39CTCF_27219007_Chip-Seq_Bcells_Human1.12259098
40BCOR_27268052_Chip-Seq_Bcells_Human1.08306653
41UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08226240
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08121637
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.07024898
44ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.06366948
45P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.03440691
46E2F1_20622854_ChIP-Seq_HELA_Human1.01477066
47TCF4_18268006_ChIP-ChIP_LS174T_Human0.99840323
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99316039
49LXR_22292898_ChIP-Seq_THP-1_Human0.98729501
50SMC4_20622854_ChIP-Seq_HELA_Human0.98656347
51* CTCF_20526341_ChIP-Seq_ESCs_Human0.97888695
52SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.97285328
53SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96288389
54DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93300567
55CLOCK_20551151_ChIP-Seq_293T_Human0.92489403
56FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.92055051
57ELK3_25401928_ChIP-Seq_HUVEC_Human0.89372603
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87297201
59FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86702699
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85588823
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84647693
62YY1_22570637_ChIP-Seq_MALME-3M_Human0.84618158
63CJUN_26792858_Chip-Seq_BT549_Human0.83575196
64AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82823282
65AR_21572438_ChIP-Seq_LNCaP_Human0.81835108
66SA1_27219007_Chip-Seq_ERYTHROID_Human0.81719090
67TP53_18474530_ChIP-ChIP_U2OS_Human0.81711471
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80999869
69P53_21459846_ChIP-Seq_SAOS-2_Human0.80986920
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80522523
71BCL6_27268052_Chip-Seq_Bcells_Human0.79683196
72* GATA4_25053715_ChIP-Seq_YYC3_Human0.79298967
73GATA6_25053715_ChIP-Seq_YYC3_Human0.79163838
74PPARA_22158963_ChIP-Seq_LIVER_Mouse0.79072645
75JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77039349
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76344840
77PPAR_26484153_Chip-Seq_NCI-H1993_Human0.76141571
78TBX20_22328084_ChIP-Seq_HEART_Mouse0.75636517
79TBX20_22080862_ChIP-Seq_HEART_Mouse0.75636517
80AHR_22903824_ChIP-Seq_MCF-7_Human0.75486655
81HNFA_21074721_ChIP-Seq_CACO-2_Human0.73065363
82CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.72705114
83RBPJ_21746931_ChIP-Seq_IB4_Human0.72070409
84TP53_16413492_ChIP-PET_HCT116_Human0.70753270
85P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70745905
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.70632505
87NRF2_20460467_ChIP-Seq_MEFs_Mouse0.70632505
88P68_20966046_ChIP-Seq_HELA_Human0.69938915
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68344630
90CEBPB_22108803_ChIP-Seq_LS180_Human0.65847286
91SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65101828
92SMAD4_21741376_ChIP-Seq_ESCs_Human0.64803705
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.64391049
94TAF2_19829295_ChIP-Seq_ESCs_Human0.61280398
95JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.59735109
96PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.59623110
97BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59333499
98KDM2B_26808549_Chip-Seq_K562_Human0.58291472
99FOXH1_21741376_ChIP-Seq_ESCs_Human0.57856698
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.57261273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier8.30357903
2MP0005275_abnormal_skin_tensile6.98284603
3MP0010234_abnormal_vibrissa_follicle6.10392581
4MP0009379_abnormal_foot_pigmentation5.03440144
5MP0000579_abnormal_nail_morphology4.92872753
6MP0005501_abnormal_skin_physiology4.64133642
7MP0004381_abnormal_hair_follicle4.08803980
8MP0001216_abnormal_epidermal_layer3.11185771
9MP0003453_abnormal_keratinocyte_physiol3.08679917
10MP0010678_abnormal_skin_adnexa2.80711507
11MP0002060_abnormal_skin_morphology2.73681109
12MP0002098_abnormal_vibrissa_morphology2.73662434
13MP0001188_hyperpigmentation2.69641778
14MP0003941_abnormal_skin_development2.63667820
15MP0010771_integument_phenotype2.63583774
16MP0002095_abnormal_skin_pigmentation2.62537185
17MP0004947_skin_inflammation2.57729574
18MP0000647_abnormal_sebaceous_gland2.48749452
19MP0000383_abnormal_hair_follicle2.47133457
20MP0000377_abnormal_hair_follicle2.44482892
21MP0000015_abnormal_ear_pigmentation2.40800760
22MP0003705_abnormal_hypodermis_morpholog2.24725895
23MP0005174_abnormal_tail_pigmentation2.13433639
24MP0005409_darkened_coat_color2.12832918
25MP0000566_synostosis2.01927007
26MP0000467_abnormal_esophagus_morphology2.00557591
27MP0005075_abnormal_melanosome_morpholog1.85388355
28MP0003011_delayed_dark_adaptation1.76594446
29MP0009931_abnormal_skin_appearance1.69447507
30MP0000367_abnormal_coat/_hair1.50826972
31MP0003191_abnormal_cellular_cholesterol1.46800496
32MP0004885_abnormal_endolymph1.40385338
33MP0000762_abnormal_tongue_morphology1.37426680
34MP0000427_abnormal_hair_cycle1.37017237
35MP0003878_abnormal_ear_physiology1.30421307
36MP0005377_hearing/vestibular/ear_phenot1.30421307
37MP0004782_abnormal_surfactant_physiolog1.28808928
38MP0003566_abnormal_cell_adhesion1.21497255
39MP0005171_absent_coat_pigmentation1.20546182
40MP0001243_abnormal_dermal_layer1.14330303
41MP0001191_abnormal_skin_condition1.12046803
42MP0002177_abnormal_outer_ear1.02916805
43MP0000372_irregular_coat_pigmentation1.00511063
44MP0000465_gastrointestinal_hemorrhage0.91253515
45MP0004264_abnormal_extraembryonic_tissu0.82475808
46MP0001851_eye_inflammation0.79882921
47MP0009053_abnormal_anal_canal0.73254071
48MP0005408_hypopigmentation0.72661817
49MP0005023_abnormal_wound_healing0.69494719
50MP0010030_abnormal_orbit_morphology0.68397242
51MP0001784_abnormal_fluid_regulation0.66682776
52MP0002877_abnormal_melanocyte_morpholog0.66615826
53MP0010352_gastrointestinal_tract_polyps0.64629738
54MP0005257_abnormal_intraocular_pressure0.63735179
55MP0001186_pigmentation_phenotype0.63029406
56MP0000569_abnormal_digit_pigmentation0.61868729
57MP0002234_abnormal_pharynx_morphology0.60227917
58MP0000371_diluted_coat_color0.55314835
59MP0003300_gastrointestinal_ulcer0.50351784
60MP0003763_abnormal_thymus_physiology0.46511839
61MP0009780_abnormal_chondrocyte_physiolo0.45679750
62MP0004043_abnormal_pH_regulation0.44467603
63MP0001984_abnormal_olfaction0.43012541
64MP0003136_yellow_coat_color0.42862402
65MP0002075_abnormal_coat/hair_pigmentati0.41900906
66MP0004185_abnormal_adipocyte_glucose0.40929148
67MP0001340_abnormal_eyelid_morphology0.40490350
68MP0002282_abnormal_trachea_morphology0.34798140
69MP0002111_abnormal_tail_morphology0.33457715
70MP0003950_abnormal_plasma_membrane0.33257440
71MP0002009_preneoplasia0.32602817
72MP0009333_abnormal_splenocyte_physiolog0.32530545
73MP0000627_abnormal_mammary_gland0.32328116
74MP0003638_abnormal_response/metabolism_0.31775690
75MP0005647_abnormal_sex_gland0.29931612
76MP0008789_abnormal_olfactory_epithelium0.29618381
77MP0003315_abnormal_perineum_morphology0.27715479
78MP0008438_abnormal_cutaneous_collagen0.26912232
79MP0004272_abnormal_basement_membrane0.26094888
80MP0002006_tumorigenesis0.24872983
81MP0008004_abnormal_stomach_pH0.24558462
82MP0005394_taste/olfaction_phenotype0.24111584
83MP0005499_abnormal_olfactory_system0.24111584
84MP0001849_ear_inflammation0.24040593
85MP0005248_abnormal_Harderian_gland0.22655849
86MP0002166_altered_tumor_susceptibility0.21794150
87MP0008260_abnormal_autophagy0.20804921
88MP0005388_respiratory_system_phenotype0.20593992
89MP0002133_abnormal_respiratory_system0.20593992
90MP0003755_abnormal_palate_morphology0.19709960
91MP0000685_abnormal_immune_system0.18681773
92MP0001958_emphysema0.17582670
93MP0005193_abnormal_anterior_eye0.17343297
94MP0005197_abnormal_uvea_morphology0.17233125
95MP0000462_abnormal_digestive_system0.16225357
96MP0004019_abnormal_vitamin_homeostasis0.14432509
97MP0001177_atelectasis0.12307299
98MP0005503_abnormal_tendon_morphology0.11933312
99MP0002233_abnormal_nose_morphology0.11002708
100MP0005508_abnormal_skeleton_morphology0.10782156

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)9.52798376
2Palmoplantar hyperkeratosis (HP:0000972)9.23689454
3Increased IgE level (HP:0003212)9.05909033
4Palmar hyperkeratosis (HP:0010765)8.78558307
5Erythroderma (HP:0001019)8.30607208
6Plantar hyperkeratosis (HP:0007556)7.98454924
7Congenital ichthyosiform erythroderma (HP:0007431)7.35758059
8Erythema (HP:0010783)7.03870675
9Hypotrichosis (HP:0001006)6.81147469
10Onycholysis (HP:0001806)6.51520830
11Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.46976901
12Conjunctival hamartoma (HP:0100780)6.21164343
13Thick nail (HP:0001805)6.14785714
14Alopecia of scalp (HP:0002293)6.08262538
15Oral leukoplakia (HP:0002745)5.41704588
16Woolly hair (HP:0002224)5.36979037
17Abnormality of secondary sexual hair (HP:0009888)5.24580815
18Abnormality of the axillary hair (HP:0100134)5.24580815
19Fragile nails (HP:0001808)5.12526875
20Parakeratosis (HP:0001036)4.85088696
21Corneal erosion (HP:0200020)4.68882543
22Pili torti (HP:0003777)4.62617331
23Palmoplantar keratoderma (HP:0000982)4.27081141
24Hamartoma of the eye (HP:0010568)4.15909199
25Abnormal blistering of the skin (HP:0008066)4.10567189
26Nail dystrophy (HP:0008404)4.02315795
27Right ventricular cardiomyopathy (HP:0011663)4.01438947
28Abnormal hair laboratory examination (HP:0003328)3.81062797
29Gangrene (HP:0100758)3.77772775
30Sparse eyelashes (HP:0000653)3.48144416
31Absent eyelashes (HP:0000561)3.46840818
32Hypohidrosis (HP:0000966)3.45956304
33Milia (HP:0001056)3.38050309
34Eczematoid dermatitis (HP:0000976)3.37749131
35Sparse scalp hair (HP:0002209)3.25395229
36Ectropion (HP:0000656)3.24938601
37Abnormality of the salivary glands (HP:0010286)3.03596619
38Lip pit (HP:0100267)2.98098373
39Ridged nail (HP:0001807)2.91439948
40Follicular hyperkeratosis (HP:0007502)2.90189298
41Absent hair (HP:0002298)2.80688404
42Brittle hair (HP:0002299)2.67317520
43Pruritus (HP:0000989)2.60809590
44Slow-growing hair (HP:0002217)2.58884880
45Abnormality of hair growth rate (HP:0011363)2.58884880
46Natal tooth (HP:0000695)2.48314760
47Melanocytic nevus (HP:0000995)2.45245182
48Blepharitis (HP:0000498)2.38988494
49Hypergammaglobulinemia (HP:0010702)2.32779424
50Hyperhidrosis (HP:0000975)2.31359440
51Advanced eruption of teeth (HP:0006288)2.21166747
52Dry hair (HP:0011359)2.10305329
53Hamartoma (HP:0010566)2.07595079
54Furrowed tongue (HP:0000221)2.07343035
55Pustule (HP:0200039)2.06153068
56Lack of skin elasticity (HP:0100679)2.02985145
57Acanthosis nigricans (HP:0000956)2.02341091
58Skin ulcer (HP:0200042)1.94418525
59Hypoplastic labia majora (HP:0000059)1.94192620
60Dehydration (HP:0001944)1.92401310
61Amniotic constriction ring (HP:0009775)1.84479288
62Abnormality of placental membranes (HP:0011409)1.84479288
63Laryngomalacia (HP:0001601)1.83553810
64Selective tooth agenesis (HP:0001592)1.83218070
65Conical tooth (HP:0000698)1.77599601
66Anonychia (HP:0001798)1.77573970
67Abnormality of the labia majora (HP:0012881)1.76148661
68Xerostomia (HP:0000217)1.75636647
69Abnormality of the neuromuscular junction (HP:0003398)1.75336176
70Fatigable weakness (HP:0003473)1.75336176
71Fine hair (HP:0002213)1.71647053
72Split foot (HP:0001839)1.70273000
73Nasolacrimal duct obstruction (HP:0000579)1.67575115
74Dry skin (HP:0000958)1.65468856
75Abnormality of permanent molar morphology (HP:0011071)1.63233861
76Abnormality of the dental root (HP:0006486)1.63233861
77Taurodontia (HP:0000679)1.63233861
78Urticaria (HP:0001025)1.62992628
79Curly hair (HP:0002212)1.60084182
80Verrucae (HP:0200043)1.56979923
81Papilloma (HP:0012740)1.56979923
82Multifactorial inheritance (HP:0001426)1.56846378
83Septate vagina (HP:0001153)1.54412641
84Ventricular tachycardia (HP:0004756)1.54203531
85Duplicated collecting system (HP:0000081)1.54181417
86Abnormality of molar morphology (HP:0011070)1.52792022
87Abnormality of molar (HP:0011077)1.52792022
88Recurrent corneal erosions (HP:0000495)1.50194819
89Carious teeth (HP:0000670)1.49779651
90Abnormality of the fingernails (HP:0001231)1.49716518
91Atrophic scars (HP:0001075)1.45590057
92Neonatal death (HP:0003811)1.44259405
93Abnormality of the dental pulp (HP:0006479)1.43122693
94Autoamputation (HP:0001218)1.42340164
95Popliteal pterygium (HP:0009756)1.40375210
96Aplasia involving bones of the extremities (HP:0009825)1.39720788
97Aplasia involving bones of the upper limbs (HP:0009823)1.39720788
98Aplasia of the phalanges of the hand (HP:0009802)1.39720788
99Oligodontia (HP:0000677)1.38373432
100Corneal dystrophy (HP:0001131)1.36996323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.63199593
2TGFBR14.61121068
3MAP3K64.53132616
4MAPKAPK34.51493824
5EEF2K4.25101843
6STK243.63149099
7FGFR13.28674434
8FER3.20248224
9MAP3K22.51814292
10FGFR32.48701224
11RIPK12.41214707
12MST1R2.22632598
13TRPM72.09801974
14MAP3K31.81716403
15PRPF4B1.81531413
16EPHA31.74884154
17RPS6KB21.69566254
18EPHB21.64853307
19PIK3CG1.61962728
20LATS11.59452375
21MAPKAPK51.56554676
22EPHB11.29429586
23MAP2K61.27934515
24ERN11.20422954
25MET1.20234138
26SGK4941.19749690
27SGK2231.19749690
28MAP3K11.16778452
29MAP3K121.16622114
30PIM21.09475303
31MAPK70.98332171
32MAPK120.94845257
33ABL20.94538609
34MAP3K90.90497445
35PTK20.90324059
36SIK10.89200991
37GRK60.87757010
38PBK0.87361887
39LATS20.85981715
40IRAK10.85366054
41MARK20.84086638
42IKBKB0.82981844
43PRKD20.82183726
44RPS6KB10.79203203
45TGFBR20.77325221
46FGFR40.75843258
47PTK60.72391501
48KSR20.72117618
49TRIB30.69082851
50MAPKAPK20.68158786
51STK30.68123259
52GSK3A0.67130546
53FGFR20.65914907
54STK38L0.63716382
55ADRBK10.62279146
56MAP3K70.61747560
57SMG10.60739252
58PDGFRA0.60613526
59TAOK10.58123997
60MYLK0.57435104
61CDK60.57379753
62LMTK20.56274574
63LRRK20.55194745
64MAP2K40.51830189
65RET0.51308323
66NLK0.49896877
67ILK0.49854864
68MTOR0.48782992
69SGK30.48738941
70PRKAA20.47743869
71ERBB30.46476386
72SGK20.45079723
73CDK120.41307534
74ICK0.39661420
75RPS6KA20.38589725
76PDGFRB0.37443376
77JAK30.36359209
78NEK60.36294563
79KIT0.35637025
80NME20.35560624
81EPHA40.34598543
82PAK40.30029317
83SGK10.29668919
84PRKCE0.29243346
85HCK0.25121577
86MAPK110.24745957
87ERBB20.24470844
88EIF2AK30.24142997
89BMX0.23251613
90PDK20.23139483
91IKBKE0.22855880
92ARAF0.22558188
93MOS0.21902981
94MINK10.21898549
95MAP2K10.21637202
96MST40.21469808
97WNK10.21423374
98ABL10.20156605
99RPS6KA10.18731497
100MAPK90.17804334

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005926.69529986
2Linoleic acid metabolism_Homo sapiens_hsa005914.77009213
3Ether lipid metabolism_Homo sapiens_hsa005653.45943235
4Fatty acid elongation_Homo sapiens_hsa000623.29457298
5Arachidonic acid metabolism_Homo sapiens_hsa005903.16305867
6Sphingolipid metabolism_Homo sapiens_hsa006002.71500305
7GnRH signaling pathway_Homo sapiens_hsa049122.36225355
8Histidine metabolism_Homo sapiens_hsa003402.28731907
9Phototransduction_Homo sapiens_hsa047442.23948345
10Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.93907558
11VEGF signaling pathway_Homo sapiens_hsa043701.91266369
12Ovarian steroidogenesis_Homo sapiens_hsa049131.80295383
13Staphylococcus aureus infection_Homo sapiens_hsa051501.68121213
14Vascular smooth muscle contraction_Homo sapiens_hsa042701.58697969
15Long-term depression_Homo sapiens_hsa047301.50362486
16Glycerophospholipid metabolism_Homo sapiens_hsa005641.42972778
17ECM-receptor interaction_Homo sapiens_hsa045121.41965677
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40523329
19Renin secretion_Homo sapiens_hsa049241.35397694
20Vitamin digestion and absorption_Homo sapiens_hsa049771.26375501
21Retinol metabolism_Homo sapiens_hsa008301.24074269
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20826048
23Phenylalanine metabolism_Homo sapiens_hsa003601.20233213
24Amoebiasis_Homo sapiens_hsa051461.13066019
25Ras signaling pathway_Homo sapiens_hsa040141.10445767
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09566317
27Glioma_Homo sapiens_hsa052141.07352393
28Serotonergic synapse_Homo sapiens_hsa047261.06007932
29Circadian rhythm_Homo sapiens_hsa047101.04555177
30Choline metabolism in cancer_Homo sapiens_hsa052311.02830413
31Dorso-ventral axis formation_Homo sapiens_hsa043201.02220715
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01848047
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98547875
34Melanogenesis_Homo sapiens_hsa049160.97983096
35Fatty acid biosynthesis_Homo sapiens_hsa000610.97075511
36Tyrosine metabolism_Homo sapiens_hsa003500.92648685
37Pertussis_Homo sapiens_hsa051330.90370457
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89401731
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.89349781
40Fat digestion and absorption_Homo sapiens_hsa049750.87377714
41Sphingolipid signaling pathway_Homo sapiens_hsa040710.87285813
42beta-Alanine metabolism_Homo sapiens_hsa004100.79331023
43Long-term potentiation_Homo sapiens_hsa047200.77674555
44p53 signaling pathway_Homo sapiens_hsa041150.76783675
45Platelet activation_Homo sapiens_hsa046110.71884292
46Acute myeloid leukemia_Homo sapiens_hsa052210.71387357
47PPAR signaling pathway_Homo sapiens_hsa033200.69574439
48Oxytocin signaling pathway_Homo sapiens_hsa049210.68375773
49Steroid biosynthesis_Homo sapiens_hsa001000.68229725
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.67836346
51Gastric acid secretion_Homo sapiens_hsa049710.67516944
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66922816
53Adherens junction_Homo sapiens_hsa045200.63427252
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62880424
55Neurotrophin signaling pathway_Homo sapiens_hsa047220.62379950
56Estrogen signaling pathway_Homo sapiens_hsa049150.62133906
57Inositol phosphate metabolism_Homo sapiens_hsa005620.59457038
58MicroRNAs in cancer_Homo sapiens_hsa052060.58775176
59Thyroid cancer_Homo sapiens_hsa052160.56615984
60Salivary secretion_Homo sapiens_hsa049700.55297406
61Bladder cancer_Homo sapiens_hsa052190.53824935
62Notch signaling pathway_Homo sapiens_hsa043300.53607465
63Endocytosis_Homo sapiens_hsa041440.52355218
64Axon guidance_Homo sapiens_hsa043600.50697658
65Insulin signaling pathway_Homo sapiens_hsa049100.49598380
66Glycerolipid metabolism_Homo sapiens_hsa005610.49364981
67Glutamatergic synapse_Homo sapiens_hsa047240.48417522
68Tuberculosis_Homo sapiens_hsa051520.47606010
69Pancreatic secretion_Homo sapiens_hsa049720.47016754
70Toxoplasmosis_Homo sapiens_hsa051450.46991077
71Aldosterone synthesis and secretion_Homo sapiens_hsa049250.46981065
72Lysosome_Homo sapiens_hsa041420.45806654
73Proteoglycans in cancer_Homo sapiens_hsa052050.44142022
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43564657
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42350238
76Focal adhesion_Homo sapiens_hsa045100.42292857
77Rap1 signaling pathway_Homo sapiens_hsa040150.41757928
78Small cell lung cancer_Homo sapiens_hsa052220.41628499
79Tight junction_Homo sapiens_hsa045300.41411137
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40605537
81Protein digestion and absorption_Homo sapiens_hsa049740.40440660
82ErbB signaling pathway_Homo sapiens_hsa040120.36463883
83Hepatitis C_Homo sapiens_hsa051600.32692726
84Glucagon signaling pathway_Homo sapiens_hsa049220.32373757
85Fatty acid metabolism_Homo sapiens_hsa012120.32325838
86Circadian entrainment_Homo sapiens_hsa047130.31700757
87ABC transporters_Homo sapiens_hsa020100.30737153
88Fatty acid degradation_Homo sapiens_hsa000710.29236066
89MAPK signaling pathway_Homo sapiens_hsa040100.27538165
90Amphetamine addiction_Homo sapiens_hsa050310.25302810
91Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24939106
92Renin-angiotensin system_Homo sapiens_hsa046140.24317589
93Pathways in cancer_Homo sapiens_hsa052000.23600115
94Renal cell carcinoma_Homo sapiens_hsa052110.22173706
95Central carbon metabolism in cancer_Homo sapiens_hsa052300.22005228
96Olfactory transduction_Homo sapiens_hsa047400.20947034
97Calcium signaling pathway_Homo sapiens_hsa040200.20897241
98Salmonella infection_Homo sapiens_hsa051320.20825468
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.19074567
100Arginine biosynthesis_Homo sapiens_hsa002200.18500334

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