LGALS3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.31999775
2positive regulation by symbiont of host defense response (GO:0052509)6.13891991
3modulation by symbiont of host defense response (GO:0052031)6.13891991
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.13891991
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.13891991
6positive regulation by organism of defense response of other organism involved in symbiotic interact6.13891991
7modulation by symbiont of host immune response (GO:0052553)6.13891991
8neutrophil activation involved in immune response (GO:0002283)6.01178031
9respiratory burst (GO:0045730)4.85971927
10regulation of interferon-beta biosynthetic process (GO:0045357)4.65829583
11positive regulation of interferon-alpha production (GO:0032727)4.61770377
12macrophage activation involved in immune response (GO:0002281)4.59999552
13immunoglobulin mediated immune response (GO:0016064)4.54043871
14glycosphingolipid catabolic process (GO:0046479)4.52280293
15regulation of interferon-alpha production (GO:0032647)4.36157862
16response to peptidoglycan (GO:0032494)4.26787896
17granulocyte activation (GO:0036230)4.26740546
18glycolipid catabolic process (GO:0019377)4.17703961
19oligosaccharide catabolic process (GO:0009313)4.07413873
20hydrogen peroxide biosynthetic process (GO:0050665)4.06607215
21positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.05856943
22angiotensin maturation (GO:0002003)4.05054343
23response to host immune response (GO:0052572)4.04925936
24response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.04925936
25neutrophil activation (GO:0042119)3.99509211
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.90685692
27positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.86792286
28natural killer cell mediated immunity (GO:0002228)3.85427627
29natural killer cell mediated cytotoxicity (GO:0042267)3.85427627
30superoxide anion generation (GO:0042554)3.82023009
31myeloid cell activation involved in immune response (GO:0002275)3.77494908
32positive regulation of antigen processing and presentation (GO:0002579)3.75019117
33positive regulation of mast cell activation (GO:0033005)3.72836191
34regulation of vitamin metabolic process (GO:0030656)3.72576026
35lipopolysaccharide-mediated signaling pathway (GO:0031663)3.71234128
36positive regulation of chemokine biosynthetic process (GO:0045080)3.66308098
37production of molecular mediator involved in inflammatory response (GO:0002532)3.65712217
38regulation of cholesterol storage (GO:0010885)3.60487395
39Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58088884
40response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.57973289
41response to host (GO:0075136)3.57973289
42response to host defenses (GO:0052200)3.57973289
43adhesion of symbiont to host cell (GO:0044650)3.56400681
44virion attachment to host cell (GO:0019062)3.56400681
45barbed-end actin filament capping (GO:0051016)3.56016662
46ceramide catabolic process (GO:0046514)3.55467077
47reactive oxygen species biosynthetic process (GO:1903409)3.54378632
48low-density lipoprotein particle clearance (GO:0034383)3.49769510
49wound healing, spreading of epidermal cells (GO:0035313)3.48078310
50positive regulation of mast cell degranulation (GO:0043306)3.39490323
51positive regulation of mast cell activation involved in immune response (GO:0033008)3.39490323
52phagosome maturation (GO:0090382)3.34100912
53B cell mediated immunity (GO:0019724)3.32896730
54response to muramyl dipeptide (GO:0032495)3.29822364
55regulation of mast cell degranulation (GO:0043304)3.29405358
56positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.29134017
57positive regulation of interferon-beta production (GO:0032728)3.28783480
58regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.28073980
59microglial cell activation (GO:0001774)3.26248730
60fat-soluble vitamin biosynthetic process (GO:0042362)3.26179698
61positive regulation of monocyte chemotaxis (GO:0090026)3.25585455
62macrophage activation (GO:0042116)3.24874712
63regulation of antigen processing and presentation (GO:0002577)3.24222745
64regulation of cytokine secretion involved in immune response (GO:0002739)3.21070497
65positive regulation of leukocyte degranulation (GO:0043302)3.19643328
66lymphocyte chemotaxis (GO:0048247)3.17804006
67membrane lipid catabolic process (GO:0046466)3.16094415
68pinocytosis (GO:0006907)3.12430003
69regulation of mast cell activation (GO:0033003)3.12300872
70myeloid dendritic cell differentiation (GO:0043011)3.12112788
71adhesion of symbiont to host (GO:0044406)3.11779498
72regulation of mast cell activation involved in immune response (GO:0033006)3.08422498
73regulation of B cell receptor signaling pathway (GO:0050855)3.07788857
74sphingolipid catabolic process (GO:0030149)3.06697416
75regulation of vitamin D biosynthetic process (GO:0060556)3.05390101
76negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.05145044
77phagocytosis, recognition (GO:0006910)3.04896932
78positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.04789319
79peptide catabolic process (GO:0043171)3.04747782
80defense response to protozoan (GO:0042832)3.03260043
81regulation of interleukin-8 biosynthetic process (GO:0045414)3.02458712
82positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.99462573
83myeloid dendritic cell activation (GO:0001773)2.97430289
84cellular extravasation (GO:0045123)2.95963937
85actin nucleation (GO:0045010)2.94221917
86regulation of leukocyte degranulation (GO:0043300)2.94179299
87interferon-gamma-mediated signaling pathway (GO:0060333)2.93994486
88cellular response to type I interferon (GO:0071357)2.91940055
89type I interferon signaling pathway (GO:0060337)2.91940055
90regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.91514530
91positive regulation of cellular amide metabolic process (GO:0034250)2.91285232
92negative regulation of mast cell activation (GO:0033004)2.90497522
93response to type I interferon (GO:0034340)2.90262755
94antigen processing and presentation of endogenous antigen (GO:0019883)2.89422407
95leukocyte mediated cytotoxicity (GO:0001909)2.88795964
96antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88116839
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88116839
98myeloid leukocyte activation (GO:0002274)2.87943343
99positive regulation of Cdc42 GTPase activity (GO:0043089)2.87166468
100Golgi transport vesicle coating (GO:0048200)2.84140750
101COPI coating of Golgi vesicle (GO:0048205)2.84140750
102regulation of podosome assembly (GO:0071801)2.82988917
103regulation of chemokine biosynthetic process (GO:0045073)2.82314813
104myeloid cell homeostasis (GO:0002262)2.81882238
105positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.81473316
106cellular response to thyroid hormone stimulus (GO:0097067)2.81325225
107amino sugar catabolic process (GO:0046348)2.80392735
108positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.78792042
109cellular response to interferon-alpha (GO:0035457)2.77737615
110regulation of dendritic cell antigen processing and presentation (GO:0002604)2.76749212
111positive regulation of gamma-delta T cell activation (GO:0046645)2.76733545
112regulation of membrane protein ectodomain proteolysis (GO:0051043)2.76692198
113negative regulation of myeloid cell apoptotic process (GO:0033033)2.76391280
114positive regulation of macrophage cytokine production (GO:0060907)2.75504081
115cellular response to zinc ion (GO:0071294)2.74670536
116T-helper 1 type immune response (GO:0042088)2.74402155
117regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74394792
118positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.74306791
119regulation of monocyte chemotaxis (GO:0090025)2.74061513
120lymphocyte mediated immunity (GO:0002449)2.73714651
121leukocyte aggregation (GO:0070486)2.73565009
122positive regulation of interleukin-6 production (GO:0032755)2.71857469
123detection of molecule of bacterial origin (GO:0032490)2.70663450
124dendritic cell differentiation (GO:0097028)2.70288084
125negative regulation of interleukin-17 production (GO:0032700)2.68859103
126response to thyroid hormone (GO:0097066)2.67325596
127protein localization to endosome (GO:0036010)2.66501786
128transcytosis (GO:0045056)2.60400616
129phospholipid efflux (GO:0033700)2.56185871
130regulation of cellular extravasation (GO:0002691)2.53482219
131negative regulation of interleukin-12 production (GO:0032695)2.51649879
132negative regulation of nitric oxide biosynthetic process (GO:0045019)2.51100117
133regulation of cholesterol esterification (GO:0010872)2.50537682
134cyclooxygenase pathway (GO:0019371)2.50522023
135fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48970229
136lipoprotein transport (GO:0042953)2.48788069
137keratan sulfate catabolic process (GO:0042340)2.48573996
138apoptotic cell clearance (GO:0043277)2.47691879
139* regulation of mononuclear cell migration (GO:0071675)2.47141318
140positive regulation of pseudopodium assembly (GO:0031274)2.44971663
141regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.44559264
142NIK/NF-kappaB signaling (GO:0038061)2.42678126
143positive regulation of extracellular matrix organization (GO:1903055)2.41361694
144protein-lipid complex assembly (GO:0065005)2.37756908
145positive regulation of triglyceride lipase activity (GO:0061365)2.37375874
146positive regulation of lipoprotein lipase activity (GO:0051006)2.37375874
147negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.35870095
148negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.34128119
149detection of other organism (GO:0098543)2.32595119
150regulation of macrophage chemotaxis (GO:0010758)2.32157208
151very-low-density lipoprotein particle assembly (GO:0034379)2.31923441
152plasma lipoprotein particle assembly (GO:0034377)2.29969201
153NADH metabolic process (GO:0006734)2.29522787
154intestinal absorption (GO:0050892)2.28777990
155regulation of superoxide anion generation (GO:0032928)2.26260490
156desmosome organization (GO:0002934)2.25785827
157regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.25773603
158amyloid precursor protein catabolic process (GO:0042987)2.25357066
159bone resorption (GO:0045453)2.23179920
160pyrimidine-containing compound transmembrane transport (GO:0072531)2.22222203
161detection of bacterium (GO:0016045)2.19136739
162regulation of metalloenzyme activity (GO:0048552)2.18790798
163negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.18520928
164regulation of cholesterol homeostasis (GO:2000188)2.18228544
165epoxygenase P450 pathway (GO:0019373)2.17031904
166fibril organization (GO:0097435)2.16886791
167fructose metabolic process (GO:0006000)2.16020101
168ethanol oxidation (GO:0006069)2.15066843
169regulation of pseudopodium assembly (GO:0031272)2.13191542
170* eosinophil chemotaxis (GO:0048245)2.11505721
171regulation of extracellular matrix disassembly (GO:0010715)2.11361126
172interferon-gamma secretion (GO:0072643)2.10122672
173ethanol metabolic process (GO:0006067)2.09013990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.72292310
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.17429028
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.98195214
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.28583250
5* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.16687854
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.03366471
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.71236659
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.55494759
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.14700751
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.05930782
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.04833702
12GATA1_22025678_ChIP-Seq_K562_Human2.95417744
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.93588960
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.85722872
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60954825
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.46711541
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43988546
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40459212
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.33432783
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29124470
21ESR2_21235772_ChIP-Seq_MCF-7_Human2.28463119
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.28123697
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23030301
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22727628
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12428247
26ZNF263_19887448_ChIP-Seq_K562_Human2.04306009
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03159525
28SPI1_23547873_ChIP-Seq_NB4_Human2.01952845
29LXR_22292898_ChIP-Seq_THP-1_Human1.95671351
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.94586439
31CLOCK_20551151_ChIP-Seq_293T_Human1.89086630
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84126771
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.76081625
34CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.73412403
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.72894818
36* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.71091058
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71031405
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.68359751
39PU_27001747_Chip-Seq_BMDM_Mouse1.68222399
40VDR_24763502_ChIP-Seq_THP-1_Human1.65480851
41VDR_24787735_ChIP-Seq_THP-1_Human1.63936283
42SPI1_23127762_ChIP-Seq_K562_Human1.63365228
43* RUNX1_22412390_ChIP-Seq_EML_Mouse1.63198929
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.61186935
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59800969
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59424125
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.59268951
48PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54785407
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54152703
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51232839
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50261052
52CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43364399
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42035827
54MYB_26560356_Chip-Seq_TH2_Human1.41878303
55LXR_22158963_ChIP-Seq_LIVER_Mouse1.41363431
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40531726
57PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40397021
58MAF_26560356_Chip-Seq_TH1_Human1.36995276
59CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36670460
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34672742
61CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34478805
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34096847
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33228457
64GATA1_19941826_ChIP-Seq_K562_Human1.31745746
65SOX2_20726797_ChIP-Seq_SW620_Human1.31324247
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.31150117
67SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30762488
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26287830
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.23465757
70VDR_21846776_ChIP-Seq_THP-1_Human1.22464442
71* GATA4_25053715_ChIP-Seq_YYC3_Human1.22206674
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20997837
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.20516749
74* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19225801
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19152982
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18432243
77NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.17680629
78NRF2_20460467_ChIP-Seq_MEFs_Mouse1.17680629
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.16347844
80* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.15099730
81* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.15099730
82RUNX1_27514584_Chip-Seq_MCF-7_Human1.14115388
83MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14059242
84* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12548824
85TFEB_21752829_ChIP-Seq_HELA_Human1.12480881
86STAT1_20625510_ChIP-Seq_HELA_Human1.12253844
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11534494
88* GATA6_25053715_ChIP-Seq_YYC3_Human1.09447387
89* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09103583
90* RUNX_20019798_ChIP-Seq_JUKART_Human1.08883352
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06137562
92MYB_26560356_Chip-Seq_TH1_Human1.05953159
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05483616
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04484684
95ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04100291
96E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03673184
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01471166
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01162415
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00022003
100FOXO3_23340844_ChIP-Seq_DLD1_Human0.99278640
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.98814021
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98156232
103GATA2_19941826_ChIP-Seq_K562_Human0.98074841
104GATA3_27048872_Chip-Seq_THYMUS_Human0.96735396
105JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96505692
106* KLF5_25053715_ChIP-Seq_YYC3_Human0.95943741
107BCOR_27268052_Chip-Seq_Bcells_Human0.94704497
108GATA3_26560356_Chip-Seq_TH2_Human0.94104193
109BCL6_27268052_Chip-Seq_Bcells_Human0.94062874
110* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93578554
111UTX_26944678_Chip-Seq_JUKART_Human0.93500021
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93155970
113SMC1_22415368_ChIP-Seq_MEFs_Mouse0.92225386
114* ATF3_27146783_Chip-Seq_COLON_Human0.92166996
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91953103
116LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91313204
117* CJUN_26792858_Chip-Seq_BT549_Human0.91069916
118* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91014084
119SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90555420
120* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88357361
121CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88344363
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87874830
123TCF7_22412390_ChIP-Seq_EML_Mouse0.87854790
124* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.87749443
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.87345469
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86662364
127* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.85893306
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.84981168
129RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84254745
130IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82321113
131EGR1_19032775_ChIP-ChIP_M12_Human0.81776772
132* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.80635470
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.79796503
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.77389786
135* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76598489
136SCL_19346495_ChIP-Seq_HPC-7_Human0.75343014
137* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74807201
138KDM2B_26808549_Chip-Seq_SUP-B15_Human0.73900538
139PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.72786687
140GATA1_22383799_ChIP-Seq_G1ME_Mouse0.71719603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.15973884
2MP0001835_abnormal_antigen_presentation4.06262572
3MP0005058_abnormal_lysosome_morphology3.81836150
4MP0002139_abnormal_hepatobiliary_system3.41804260
5MP0002148_abnormal_hypersensitivity_rea3.32412442
6MP0009785_altered_susceptibility_to3.29754354
7* MP0002419_abnormal_innate_immunity3.09278791
8MP0005000_abnormal_immune_tolerance2.97415364
9* MP0005025_abnormal_response_to2.72612097
10* MP0006082_CNS_inflammation2.65145301
11MP0001790_abnormal_immune_system2.46508427
12MP0005387_immune_system_phenotype2.46508427
13* MP0002452_abnormal_antigen_presenting2.45399636
14MP0003172_abnormal_lysosome_physiology2.32738938
15MP0004510_myositis2.32671711
16MP0000685_abnormal_immune_system2.24913270
17* MP0003303_peritoneal_inflammation2.24045263
18MP0001533_abnormal_skeleton_physiology2.23625530
19MP0003724_increased_susceptibility_to2.20170853
20MP0002723_abnormal_immune_serum2.19748675
21MP0005257_abnormal_intraocular_pressure2.16494918
22MP0005671_abnormal_response_to2.10835895
23MP0004947_skin_inflammation2.05340639
24MP0003448_altered_tumor_morphology2.04105157
25MP0005464_abnormal_platelet_physiology2.02523178
26* MP0001800_abnormal_humoral_immune2.02168900
27MP0005360_urolithiasis2.01067271
28* MP0001819_abnormal_immune_cell1.99232518
29* MP0002420_abnormal_adaptive_immunity1.95295975
30MP0000343_altered_response_to1.92020928
31MP0003300_gastrointestinal_ulcer1.91172876
32MP0003191_abnormal_cellular_cholesterol1.89190475
33MP0005365_abnormal_bile_salt1.82659067
34MP0009840_abnormal_foam_cell1.81941366
35MP0005451_abnormal_body_composition1.79137231
36* MP0001845_abnormal_inflammatory_respons1.74539109
37* MP0002405_respiratory_system_inflammati1.73360324
38MP0004019_abnormal_vitamin_homeostasis1.72572468
39MP0002998_abnormal_bone_remodeling1.71453402
40MP0000604_amyloidosis1.69445307
41MP0001853_heart_inflammation1.67535774
42MP0000569_abnormal_digit_pigmentation1.65199483
43MP0005310_abnormal_salivary_gland1.64313320
44MP0003705_abnormal_hypodermis_morpholog1.63048398
45MP0009764_decreased_sensitivity_to1.62815948
46MP0002877_abnormal_melanocyte_morpholog1.62671289
47MP0003690_abnormal_glial_cell1.58790231
48MP0000858_altered_metastatic_potential1.57573501
49MP0003566_abnormal_cell_adhesion1.55392892
50MP0003075_altered_response_to1.54929680
51* MP0010155_abnormal_intestine_physiology1.54069229
52MP0008469_abnormal_protein_level1.52161700
53MP0003329_amyloid_beta_deposits1.50135738
54MP0004264_abnormal_extraembryonic_tissu1.49991952
55MP0003806_abnormal_nucleotide_metabolis1.49542795
56MP0009333_abnormal_splenocyte_physiolog1.47528179
57MP0010307_abnormal_tumor_latency1.45740029
58MP0000566_synostosis1.38510952
59MP0005085_abnormal_gallbladder_physiolo1.37793147
60MP0008438_abnormal_cutaneous_collagen1.34928522
61MP0001851_eye_inflammation1.33836978
62* MP0000716_abnormal_immune_system1.29640796
63MP0001664_abnormal_digestion1.29363820
64MP0002796_impaired_skin_barrier1.28274281
65MP0003453_abnormal_keratinocyte_physiol1.26375800
66MP0005167_abnormal_blood-brain_barrier1.26163650
67MP0005165_increased_susceptibility_to1.26067196
68MP0001666_abnormal_nutrient_absorption1.24442682
69MP0010386_abnormal_urinary_bladder1.21185876
70* MP0005166_decreased_susceptibility_to1.20312452
71MP0004782_abnormal_surfactant_physiolog1.17371145
72MP0008260_abnormal_autophagy1.17340840
73MP0005390_skeleton_phenotype1.16991440
74MP0008004_abnormal_stomach_pH1.16404160
75MP0002254_reproductive_system_inflammat1.15977383
76MP0002006_tumorigenesis1.14984245
77MP0002933_joint_inflammation1.14722873
78MP0010234_abnormal_vibrissa_follicle1.14156711
79MP0005076_abnormal_cell_differentiation1.13323892
80MP0006054_spinal_hemorrhage1.12686492
81MP0005164_abnormal_response_to1.11021890
82* MP0002398_abnormal_bone_marrow1.10813848
83MP0009278_abnormal_bone_marrow1.10713249
84MP0005174_abnormal_tail_pigmentation1.07012352
85MP0003186_abnormal_redox_activity1.06936470
86MP0005397_hematopoietic_system_phenotyp1.06153602
87MP0001545_abnormal_hematopoietic_system1.06153602
88MP0001958_emphysema1.05888378
89MP0003828_pulmonary_edema1.05289389
90MP0010678_abnormal_skin_adnexa1.04527466
91MP0000689_abnormal_spleen_morphology1.03958531
92* MP0002429_abnormal_blood_cell1.03397540
93MP0010352_gastrointestinal_tract_polyps1.02441119
94* MP0005381_digestive/alimentary_phenotyp1.00490883
95MP0009643_abnormal_urine_homeostasis0.99722211
96MP0000490_abnormal_crypts_of0.99493263
97MP0005409_darkened_coat_color0.98459675
98MP0002722_abnormal_immune_system0.95274550
99MP0008875_abnormal_xenobiotic_pharmacok0.94700286
100MP0003183_abnormal_peptide_metabolism0.93597908
101MP0002138_abnormal_hepatobiliary_system0.92172686
102MP0001849_ear_inflammation0.90557750
103MP0003795_abnormal_bone_structure0.89223746
104MP0003091_abnormal_cell_migration0.88020155
105MP0005501_abnormal_skin_physiology0.87876281
106MP0004043_abnormal_pH_regulation0.87200529
107MP0003866_abnormal_defecation0.86652928
108MP0005670_abnormal_white_adipose0.86363876
109MP0002166_altered_tumor_susceptibility0.86357251
110MP0002277_abnormal_respiratory_mucosa0.86092651
111MP0002896_abnormal_bone_mineralization0.83597681
112MP0002090_abnormal_vision0.83350592
113MP0005023_abnormal_wound_healing0.81650251
114MP0000477_abnormal_intestine_morphology0.79725272
115MP0003656_abnormal_erythrocyte_physiolo0.78453367
116MP0005275_abnormal_skin_tensile0.77299508
117MP0001542_abnormal_bone_strength0.76619367
118MP0000249_abnormal_blood_vessel0.76112651
119MP0000465_gastrointestinal_hemorrhage0.76040105
120* MP0009763_increased_sensitivity_to0.75191999
121MP0000371_diluted_coat_color0.69764459
122MP0001873_stomach_inflammation0.69182731
123MP0001216_abnormal_epidermal_layer0.68285515
124* MP0002136_abnormal_kidney_physiology0.66899384
125* MP0001663_abnormal_digestive_system0.66388284
126MP0004185_abnormal_adipocyte_glucose0.66299146
127MP0003279_aneurysm0.63962621
128MP0000015_abnormal_ear_pigmentation0.62229526
129MP0004883_abnormal_blood_vessel0.60374518

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.04570865
2Recurrent abscess formation (HP:0002722)6.82102056
3Recurrent gram-negative bacterial infections (HP:0005420)6.13353620
4Recurrent bacterial skin infections (HP:0005406)6.01556832
5Increased cerebral lipofuscin (HP:0011813)5.83787072
6Vacuolated lymphocytes (HP:0001922)5.71985974
7Abnormality of macrophages (HP:0004311)5.46942407
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.92219130
9Axonal loss (HP:0003447)4.29028704
10Disinhibition (HP:0000734)4.22845776
11Abnormality of glycolipid metabolism (HP:0010969)4.22805188
12Abnormality of liposaccharide metabolism (HP:0010968)4.22805188
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.22805188
14Mediastinal lymphadenopathy (HP:0100721)4.13453150
15Gingivitis (HP:0000230)3.94882384
16Dysostosis multiplex (HP:0000943)3.89960244
17Chronic obstructive pulmonary disease (HP:0006510)3.87642768
18Obstructive lung disease (HP:0006536)3.87642768
19Systemic lupus erythematosus (HP:0002725)3.83829728
20Malnutrition (HP:0004395)3.69908836
21Recurrent skin infections (HP:0001581)3.66521891
22Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.61416914
23Autoimmune thrombocytopenia (HP:0001973)3.56589216
24Stomatitis (HP:0010280)3.43090563
25Recurrent fungal infections (HP:0002841)3.36943532
26Elevated erythrocyte sedimentation rate (HP:0003565)3.34127797
27Urinary glycosaminoglycan excretion (HP:0003541)3.33960682
28Mucopolysacchariduria (HP:0008155)3.33960682
29Myositis (HP:0100614)3.21103538
30Hyperactive renin-angiotensin system (HP:0000841)3.15174880
31Abnormality of the nasal mucosa (HP:0000433)3.11188101
32Abnormality of polysaccharide metabolism (HP:0011012)3.09205129
33Abnormality of glycosaminoglycan metabolism (HP:0004371)3.09205129
34Abnormality of mucopolysaccharide metabolism (HP:0011020)3.09205129
35Myocardial infarction (HP:0001658)3.08015727
36Loss of speech (HP:0002371)3.05914905
37Orchitis (HP:0100796)3.05795407
38Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.00374856
39Amyloidosis (HP:0011034)3.00031426
40Basal ganglia calcification (HP:0002135)2.99986775
41Interstitial pulmonary disease (HP:0006530)2.98688924
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93786783
43Cellulitis (HP:0100658)2.85950420
44Urticaria (HP:0001025)2.84506139
45Prostate neoplasm (HP:0100787)2.83044529
46Nasal polyposis (HP:0100582)2.79372411
47Fat malabsorption (HP:0002630)2.76017305
48Neurofibrillary tangles (HP:0002185)2.74354349
49Agnosia (HP:0010524)2.73603443
50Hepatosplenomegaly (HP:0001433)2.71249866
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.70142868
52Pustule (HP:0200039)2.66213283
53Thick nail (HP:0001805)2.65806303
54Steatorrhea (HP:0002570)2.65121828
55Purpura (HP:0000979)2.57376168
56Periodontitis (HP:0000704)2.54767422
57Retrobulbar optic neuritis (HP:0100654)2.53740015
58Optic neuritis (HP:0100653)2.53740015
59Vasculitis (HP:0002633)2.53320884
60Nuclear cataract (HP:0100018)2.52351158
61Chronic mucocutaneous candidiasis (HP:0002728)2.45679459
62Recurrent cutaneous fungal infections (HP:0011370)2.45679459
63Xanthomatosis (HP:0000991)2.42100559
64Abnormality of the vasculature of the conjunctiva (HP:0008054)2.41639002
65Osteomyelitis (HP:0002754)2.40455167
66Abnormality of monocarboxylic acid metabolism (HP:0010996)2.38095249
67Recurrent pneumonia (HP:0006532)2.36815235
68Glomerulonephritis (HP:0000099)2.34739633
69Abnormality of complement system (HP:0005339)2.31679986
70Recurrent viral infections (HP:0004429)2.30683199
71Diminished motivation (HP:0000745)2.30424052
72Petechiae (HP:0000967)2.30308561
73Vertebral compression fractures (HP:0002953)2.29982813
74Abnormality of proline metabolism (HP:0010907)2.28704855
75Hydroxyprolinuria (HP:0003080)2.28704855
76Complement deficiency (HP:0004431)2.27256835
77Pathologic fracture (HP:0002756)2.25040834
78Flat acetabular roof (HP:0003180)2.21955094
79Bone pain (HP:0002653)2.21544152
80Tetraparesis (HP:0002273)2.20365795
81Abnormality of the lumbar spine (HP:0100712)2.18667803
82Apathy (HP:0000741)2.18407920
83Thin bony cortex (HP:0002753)2.16810901
84Osteolytic defects of the phalanges of the hand (HP:0009771)2.16655535
85Osteolytic defects of the hand bones (HP:0009699)2.16655535
86Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16504065
87Decreased circulating renin level (HP:0003351)2.16302691
88Upper motor neuron abnormality (HP:0002127)2.13630721
89J-shaped sella turcica (HP:0002680)2.12145803
90Poor head control (HP:0002421)2.11196771
91Nausea (HP:0002018)2.11110760
92Abdominal distention (HP:0003270)2.10019325
93Chronic diarrhea (HP:0002028)2.07489599
94Premature loss of primary teeth (HP:0006323)2.03771871
95Recurrent lower respiratory tract infections (HP:0002783)2.03505881
96Asymmetric septal hypertrophy (HP:0001670)2.03052057
97Cerebral inclusion bodies (HP:0100314)2.01844812
98Distal lower limb muscle weakness (HP:0009053)2.01243520
99Inappropriate behavior (HP:0000719)1.98626856
100Conjunctival telangiectasia (HP:0000524)1.97239393
101Cervical subluxation (HP:0003308)1.97033269
102Hemorrhage of the eye (HP:0011885)1.95571557
103Meningitis (HP:0001287)1.95495957
104Leukocytosis (HP:0001974)1.94022290
105Hypergammaglobulinemia (HP:0010702)1.93646786
106Cheilitis (HP:0100825)1.93173294
107Peripheral demyelination (HP:0011096)1.93048752
108Metaphyseal irregularity (HP:0003025)1.92986780
109Personality changes (HP:0000751)1.91898055
110Pulmonary infiltrates (HP:0002113)1.90899493
111Chronic otitis media (HP:0000389)1.89370989
112Prolonged neonatal jaundice (HP:0006579)1.89198768
113Nephritis (HP:0000123)1.88437866
114Gingival bleeding (HP:0000225)1.87477238
115Multiple lipomas (HP:0001012)1.86798610
116Hyperparathyroidism (HP:0000843)1.86410403
117Progressive neurologic deterioration (HP:0002344)1.85842650
118Hematochezia (HP:0002573)1.85587965
119Increased IgE level (HP:0003212)1.84862214
120Intrahepatic cholestasis (HP:0001406)1.84523668
121Sepsis (HP:0100806)1.84441111
122Abnormality of renin-angiotensin system (HP:0000847)1.83919964
123Polyneuropathy (HP:0001271)1.83019568
124Increased IgM level (HP:0003496)1.81846783
125Segmental peripheral demyelination/remyelination (HP:0003481)1.81796244
126Protuberant abdomen (HP:0001538)1.81283001
127Mutism (HP:0002300)1.80494431
128Hemoptysis (HP:0002105)1.80363403
129Skin nodule (HP:0200036)1.80187602
130Arterial thrombosis (HP:0004420)1.79441823
131Thoracic kyphosis (HP:0002942)1.78684297
132Bone cyst (HP:0012062)1.78615737
133Dementia (HP:0000726)1.77439442
134Abnormality of chloride homeostasis (HP:0011422)1.76460569
135Right ventricular cardiomyopathy (HP:0011663)1.76116597
136Progressive visual loss (HP:0000529)1.75932890
137Esophageal varix (HP:0002040)1.74928566
138Skin ulcer (HP:0200042)1.73951470
139Abnormality of the distal phalanges of the toes (HP:0010182)1.72986170
140Abnormality of fatty-acid metabolism (HP:0004359)1.71296765
141Neuronal loss in central nervous system (HP:0002529)1.70373762
142Increased serum ferritin (HP:0003281)1.69862150
143Albinism (HP:0001022)1.68594856
144Joint hemorrhage (HP:0005261)1.68067778
145Mucosal telangiectasiae (HP:0100579)1.67962235
146Rhinitis (HP:0012384)1.67927326
147Abnormality of the pericardium (HP:0001697)1.67451050
148Increased CSF protein (HP:0002922)1.66737458
149Abnormal respiratory epithelium morphology (HP:0012253)1.65235855
150Abnormal respiratory motile cilium morphology (HP:0005938)1.65235855
151Abnormal respiratory motile cilium physiology (HP:0012261)1.65046442
152Cardiomegaly (HP:0001640)1.64228676

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK4.41200613
2RIPK44.16567466
3BLK3.56416163
4MAP3K143.36809082
5TBK13.31789184
6MKNK23.31509952
7EPHA23.09310909
8NME22.91673079
9PIM22.71911548
10ERN12.70108862
11ACVR1B2.54678462
12IRAK32.53508316
13IRAK42.50049236
14KIT2.41902097
15TYK22.39208457
16MAP4K12.00672731
17IKBKE1.92879955
18MST1R1.92502522
19IKBKB1.87876781
20NEK91.84558316
21MST41.79041401
22BMX1.72988567
23PDK21.70246734
24LMTK21.61581346
25MKNK11.55476165
26PRPF4B1.55415670
27TRIB31.53139224
28JAK31.52831676
29JAK11.49327008
30TESK11.44932780
31CSK1.39924962
32RPS6KA41.31664000
33TRPM71.29849088
34TAOK31.28450529
35HCK1.26541266
36ZAP701.24227112
37TXK1.23383028
38SYK1.19756368
39EPHB11.18675860
40MAP3K31.17376609
41FGR1.16315739
42MYLK1.14587578
43CDC42BPA1.11800671
44MAP3K121.09946601
45EPHB21.09069563
46MAP3K111.08543899
47MAPK151.07810301
48TTN1.05794539
49LYN1.04870627
50CSF1R1.04511403
51STK101.04189038
52SCYL21.03496693
53JAK21.02889656
54MAPKAPK30.99923308
55MATK0.99228637
56CHUK0.98513915
57PIM10.97866524
58MAP2K30.96549144
59MAP3K130.96359603
60TGFBR20.95693357
61LCK0.92373618
62RIPK10.92223078
63PIK3CA0.91671347
64TESK20.88311619
65PKN20.87340254
66LRRK20.87115256
67MOS0.85838161
68ERBB30.84775087
69MARK30.83798138
70BTK0.81200061
71SIK10.79972971
72MAP3K50.77327111
73PDGFRA0.76570527
74STK40.76099790
75PTK60.73991448
76CDK60.70811688
77PRKCD0.70770902
78EGFR0.70662161
79FGFR30.68814687
80TEC0.68683622
81FES0.63708615
82PRKG20.62512427
83EPHA30.62380027
84DAPK30.61335583
85* ABL10.58871700
86ITK0.57173680
87ARAF0.56796319
88MAP3K10.56238105
89GRK70.54926763
90PAK40.54254640
91MAP2K20.53176689
92STK30.51016866
93MAPKAPK20.50422766
94YES10.50067465
95TAOK20.49785304
96PTK20.48816082
97BMPR20.48765550
98MAP2K60.48607640
99DDR20.47575577
100KSR20.47028266
101MAP3K20.46804356
102TAOK10.43520778
103PDK10.43199722
104SMG10.43056209
105* ABL20.42813274
106PDPK10.42157314
107DYRK1B0.41992809
108FER0.41582764
109SIK30.41277591
110FGFR40.40431223
111RPS6KA20.39665899
112ERBB40.39072256
113ICK0.37486952
114GRK60.37140865
115FYN0.36924310
116DMPK0.36175177
117PDGFRB0.35423120
118MAP3K100.34606323
119MAP3K60.33540606
120MAP3K80.33523204
121MET0.33306270
122STK240.32970571
123SRC0.32373906
124LIMK10.32065261
125CAMK2G0.31719306
126PRKCQ0.31209787
127EIF2AK20.30932636
128GSK3A0.25836903
129ADRBK20.25314838
130NEK60.23483598

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.22429785
2Lysosome_Homo sapiens_hsa041423.05555855
3Staphylococcus aureus infection_Homo sapiens_hsa051502.63540762
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.55225280
5Osteoclast differentiation_Homo sapiens_hsa043802.48795469
6Tuberculosis_Homo sapiens_hsa051522.47594454
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.43378778
8Phagosome_Homo sapiens_hsa041452.41307206
9Rheumatoid arthritis_Homo sapiens_hsa053232.37475834
10Pertussis_Homo sapiens_hsa051332.23160122
11Legionellosis_Homo sapiens_hsa051342.22510556
12Graft-versus-host disease_Homo sapiens_hsa053322.22299094
13Malaria_Homo sapiens_hsa051442.18763737
14Other glycan degradation_Homo sapiens_hsa005112.07393808
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.06782352
16Salmonella infection_Homo sapiens_hsa051321.95903716
17Sulfur metabolism_Homo sapiens_hsa009201.95616370
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91839335
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87042542
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.70104968
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.69329842
22PPAR signaling pathway_Homo sapiens_hsa033201.67894437
23Allograft rejection_Homo sapiens_hsa053301.65425519
24Collecting duct acid secretion_Homo sapiens_hsa049661.62046075
25Asthma_Homo sapiens_hsa053101.61010007
26Shigellosis_Homo sapiens_hsa051311.59884832
27TNF signaling pathway_Homo sapiens_hsa046681.59478375
28Measles_Homo sapiens_hsa051621.54830819
29Apoptosis_Homo sapiens_hsa042101.52889217
30Toxoplasmosis_Homo sapiens_hsa051451.52449433
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50623389
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48340117
33Fructose and mannose metabolism_Homo sapiens_hsa000511.48028516
34Influenza A_Homo sapiens_hsa051641.47453744
35Antigen processing and presentation_Homo sapiens_hsa046121.47069390
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46291427
37Fat digestion and absorption_Homo sapiens_hsa049751.46141618
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.43959346
39B cell receptor signaling pathway_Homo sapiens_hsa046621.43946275
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41830988
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.40327937
42Vitamin digestion and absorption_Homo sapiens_hsa049771.34394645
43Hematopoietic cell lineage_Homo sapiens_hsa046401.33669240
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.32405109
45Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27795011
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.25308340
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21300176
48Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20578921
49Chemokine signaling pathway_Homo sapiens_hsa040621.19176245
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.16746903
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.15960144
52Chemical carcinogenesis_Homo sapiens_hsa052041.11828742
53Viral myocarditis_Homo sapiens_hsa054161.10994497
54Jak-STAT signaling pathway_Homo sapiens_hsa046301.10217798
55Mineral absorption_Homo sapiens_hsa049781.06483601
56Glutathione metabolism_Homo sapiens_hsa004801.03076825
57Amoebiasis_Homo sapiens_hsa051461.03040040
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01456351
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99670285
60Hepatitis C_Homo sapiens_hsa051600.97571570
61Sphingolipid metabolism_Homo sapiens_hsa006000.97193597
62Hepatitis B_Homo sapiens_hsa051610.97091320
63Herpes simplex infection_Homo sapiens_hsa051680.96548303
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95910008
65Type I diabetes mellitus_Homo sapiens_hsa049400.94674201
66African trypanosomiasis_Homo sapiens_hsa051430.93926085
67Vibrio cholerae infection_Homo sapiens_hsa051100.93153041
68Starch and sucrose metabolism_Homo sapiens_hsa005000.92528861
69Fatty acid degradation_Homo sapiens_hsa000710.92201755
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89762151
71Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88367259
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88075218
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85015784
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.83798906
75Phenylalanine metabolism_Homo sapiens_hsa003600.82168053
76Protein digestion and absorption_Homo sapiens_hsa049740.80299738
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.79992528
78Acute myeloid leukemia_Homo sapiens_hsa052210.76671041
79Glycerolipid metabolism_Homo sapiens_hsa005610.74316162
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73790155
81Chronic myeloid leukemia_Homo sapiens_hsa052200.72779164
82Caffeine metabolism_Homo sapiens_hsa002320.72006389
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71961843
84Tryptophan metabolism_Homo sapiens_hsa003800.71630867
85Tyrosine metabolism_Homo sapiens_hsa003500.70452172
86Complement and coagulation cascades_Homo sapiens_hsa046100.69256472
87Platelet activation_Homo sapiens_hsa046110.68999673
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68732363
89Fatty acid elongation_Homo sapiens_hsa000620.67184229
90Renin-angiotensin system_Homo sapiens_hsa046140.66376876
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.65558247
92Steroid biosynthesis_Homo sapiens_hsa001000.65038160
93Pancreatic cancer_Homo sapiens_hsa052120.64294425
94HIF-1 signaling pathway_Homo sapiens_hsa040660.63739780
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63595790
96Retinol metabolism_Homo sapiens_hsa008300.62472011
97T cell receptor signaling pathway_Homo sapiens_hsa046600.60993991
98Endocytosis_Homo sapiens_hsa041440.59994334
99Pentose phosphate pathway_Homo sapiens_hsa000300.59403972
100Autoimmune thyroid disease_Homo sapiens_hsa053200.59129054
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59037570
102Proteoglycans in cancer_Homo sapiens_hsa052050.57250814
103Arachidonic acid metabolism_Homo sapiens_hsa005900.57151674
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.56904149
105Primary immunodeficiency_Homo sapiens_hsa053400.56809543
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56199275
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.53451827
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53344618
109Prolactin signaling pathway_Homo sapiens_hsa049170.53111585
110Arginine biosynthesis_Homo sapiens_hsa002200.50466140
111Bile secretion_Homo sapiens_hsa049760.50356750
112VEGF signaling pathway_Homo sapiens_hsa043700.47963274
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.47128216
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46879027
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42596572
116Prion diseases_Homo sapiens_hsa050200.40561246
117Viral carcinogenesis_Homo sapiens_hsa052030.39370964
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37661229
119Galactose metabolism_Homo sapiens_hsa000520.36427257
120Epstein-Barr virus infection_Homo sapiens_hsa051690.35683278
121Adherens junction_Homo sapiens_hsa045200.31420278
122Small cell lung cancer_Homo sapiens_hsa052220.30717678
123Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28208042
124Focal adhesion_Homo sapiens_hsa045100.28121854
125Histidine metabolism_Homo sapiens_hsa003400.27830458
126Renal cell carcinoma_Homo sapiens_hsa052110.27715628
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25553677
128Bladder cancer_Homo sapiens_hsa052190.23752681
129Type II diabetes mellitus_Homo sapiens_hsa049300.21852572
130Dorso-ventral axis formation_Homo sapiens_hsa043200.18258491
131Insulin resistance_Homo sapiens_hsa049310.17960369
132ECM-receptor interaction_Homo sapiens_hsa045120.17235442

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