LETM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.88476932
2sperm motility (GO:0030317)7.33810485
3fusion of sperm to egg plasma membrane (GO:0007342)6.81269114
4acrosome reaction (GO:0007340)6.73548579
5axonemal dynein complex assembly (GO:0070286)6.67844407
6motile cilium assembly (GO:0044458)6.14967460
7multicellular organism reproduction (GO:0032504)6.03672664
8acrosome assembly (GO:0001675)5.97254026
9epithelial cilium movement (GO:0003351)5.95185627
10plasma membrane fusion (GO:0045026)5.53419469
11regulation of cilium movement (GO:0003352)5.48592099
12sperm-egg recognition (GO:0035036)5.34326924
13cilium movement (GO:0003341)5.24498161
14piRNA metabolic process (GO:0034587)4.97529873
15spermatid development (GO:0007286)4.97050236
16behavioral response to nicotine (GO:0035095)4.91027390
17cell-cell recognition (GO:0009988)4.81392929
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.79030174
19cell wall macromolecule catabolic process (GO:0016998)4.76563979
20cell wall macromolecule metabolic process (GO:0044036)4.76563979
21reproduction (GO:0000003)4.66981667
22binding of sperm to zona pellucida (GO:0007339)4.63351528
23single fertilization (GO:0007338)4.38478051
24negative regulation of inclusion body assembly (GO:0090084)4.33602732
25DNA deamination (GO:0045006)4.23805694
26male meiosis (GO:0007140)4.10799220
27microtubule depolymerization (GO:0007019)4.00079999
28calcium ion-dependent exocytosis (GO:0017156)3.89216197
29cellular ketone body metabolic process (GO:0046950)3.87250549
30sperm capacitation (GO:0048240)3.82357563
31DNA methylation involved in gamete generation (GO:0043046)3.81177119
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.69319535
33protein localization to cilium (GO:0061512)3.63988134
34gamma-aminobutyric acid transport (GO:0015812)3.61453350
35axoneme assembly (GO:0035082)3.58326204
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.57944405
37NADH dehydrogenase complex assembly (GO:0010257)3.57944405
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57944405
39ketone body metabolic process (GO:1902224)3.49329566
40ventricular system development (GO:0021591)3.47939568
41fucose catabolic process (GO:0019317)3.47700121
42L-fucose metabolic process (GO:0042354)3.47700121
43L-fucose catabolic process (GO:0042355)3.47700121
44negative regulation of telomere maintenance (GO:0032205)3.47478016
45protein complex biogenesis (GO:0070271)3.44458096
46single strand break repair (GO:0000012)3.42052166
47fertilization (GO:0009566)3.41690021
48adaptation of signaling pathway (GO:0023058)3.35339480
49neural tube formation (GO:0001841)3.35186753
50spermatogenesis (GO:0007283)3.33314956
51male gamete generation (GO:0048232)3.31839700
52synaptonemal complex organization (GO:0070193)3.27556885
53indolalkylamine metabolic process (GO:0006586)3.26266729
54intraciliary transport (GO:0042073)3.24936855
55protein polyglutamylation (GO:0018095)3.22607279
56protein-cofactor linkage (GO:0018065)3.21001894
57male meiosis I (GO:0007141)3.14030509
58respiratory chain complex IV assembly (GO:0008535)3.13368143
59mitochondrial respiratory chain complex assembly (GO:0033108)3.12903767
60indole-containing compound catabolic process (GO:0042436)3.12843822
61indolalkylamine catabolic process (GO:0046218)3.12843822
62tryptophan catabolic process (GO:0006569)3.12843822
63cilium assembly (GO:0042384)3.12572668
64ionotropic glutamate receptor signaling pathway (GO:0035235)3.12373817
65kynurenine metabolic process (GO:0070189)3.11576193
66cilium organization (GO:0044782)3.10746940
67negative regulation of mast cell activation (GO:0033004)3.09154247
68gamete generation (GO:0007276)3.07622398
69preassembly of GPI anchor in ER membrane (GO:0016254)3.06468741
70regulation of microtubule-based movement (GO:0060632)3.05560377
71protein K11-linked deubiquitination (GO:0035871)3.02716049
72synaptic transmission, cholinergic (GO:0007271)2.99941376
73seminiferous tubule development (GO:0072520)2.95602050
74synaptonemal complex assembly (GO:0007130)2.90279554
75cell recognition (GO:0008037)2.89996461
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87901382
77left/right pattern formation (GO:0060972)2.87587476
78glutamate receptor signaling pathway (GO:0007215)2.86939733
79organic cation transport (GO:0015695)2.86407354
80platelet dense granule organization (GO:0060155)2.83961856
81calcium ion import (GO:0070509)2.82674092
82membrane depolarization during action potential (GO:0086010)2.82630399
83water-soluble vitamin biosynthetic process (GO:0042364)2.80471897
84presynaptic membrane organization (GO:0097090)2.80418919
85synaptic transmission, glutamatergic (GO:0035249)2.79292579
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.77512991
87photoreceptor cell maintenance (GO:0045494)2.76782679
88replication fork processing (GO:0031297)2.76126605
89centriole replication (GO:0007099)2.74887954
90startle response (GO:0001964)2.72482523
91presynaptic membrane assembly (GO:0097105)2.72452977
92negative regulation of transcription regulatory region DNA binding (GO:2000678)2.72383197
93behavioral response to ethanol (GO:0048149)2.71322365
94cytochrome complex assembly (GO:0017004)2.71284275
95tryptophan metabolic process (GO:0006568)2.70914480
96rhodopsin mediated signaling pathway (GO:0016056)2.70863923
97cellular component assembly involved in morphogenesis (GO:0010927)2.69914206
98photoreceptor cell development (GO:0042461)2.68610686
99transmission of nerve impulse (GO:0019226)2.68576589
100glycerophospholipid catabolic process (GO:0046475)2.68434794
101response to pheromone (GO:0019236)2.67867475
102neuron cell-cell adhesion (GO:0007158)2.67691898
103regulation of regulatory T cell differentiation (GO:0045589)2.66458728
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.63963452
105regulation of inclusion body assembly (GO:0090083)2.63154978
106germ cell development (GO:0007281)2.62997368
107indole-containing compound metabolic process (GO:0042430)2.61466944
108negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60541139
109ubiquinone biosynthetic process (GO:0006744)2.59930487
110pyrimidine nucleobase catabolic process (GO:0006208)2.59115747
111cellular process involved in reproduction in multicellular organism (GO:0022412)2.58224180
112negative regulation of neurotransmitter transport (GO:0051589)2.57228053
113rRNA catabolic process (GO:0016075)2.57037707
114cornea development in camera-type eye (GO:0061303)2.56563313
115recombinational repair (GO:0000725)2.54432635
116regulation of telomere maintenance (GO:0032204)2.54335797
117serotonin metabolic process (GO:0042428)2.54178062
118regulation of nuclear cell cycle DNA replication (GO:0033262)2.53915327
119regulation of hexokinase activity (GO:1903299)2.53748269
120regulation of glucokinase activity (GO:0033131)2.53748269
121retinal cone cell development (GO:0046549)2.53549024
122regulation of action potential (GO:0098900)2.53415376
123double-strand break repair via homologous recombination (GO:0000724)2.52955660
124negative regulation of neurotransmitter secretion (GO:0046929)2.52946982
125regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.51839239
126C-terminal protein amino acid modification (GO:0018410)2.50988230
127dopamine transport (GO:0015872)2.50725693
128detection of mechanical stimulus involved in sensory perception (GO:0050974)2.50508910
129regulation of neurotransmitter uptake (GO:0051580)2.50213322
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50148791
131neuron-neuron synaptic transmission (GO:0007270)2.49194104
132primary amino compound metabolic process (GO:1901160)2.48537822
133ubiquinone metabolic process (GO:0006743)2.46837161
134somite development (GO:0061053)2.46690180
135RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45805008
136DNA double-strand break processing (GO:0000729)2.45495370
137C-terminal protein lipidation (GO:0006501)2.45460395
138GPI anchor metabolic process (GO:0006505)2.45183362
139membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44984639
140protein localization to synapse (GO:0035418)2.43907497
141kidney morphogenesis (GO:0060993)2.42437539
142protein K6-linked ubiquitination (GO:0085020)2.42068414
143RNA destabilization (GO:0050779)2.42065332
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.41545328
145reciprocal DNA recombination (GO:0035825)2.41416166
146reciprocal meiotic recombination (GO:0007131)2.41416166
147microtubule polymerization or depolymerization (GO:0031109)2.39627252
148cilium morphogenesis (GO:0060271)2.39435534
149meiotic cell cycle (GO:0051321)2.39395705
150multicellular organismal reproductive process (GO:0048609)2.38866893
151cerebellar Purkinje cell differentiation (GO:0021702)2.38527353
152detection of light stimulus involved in visual perception (GO:0050908)2.37626538
153detection of light stimulus involved in sensory perception (GO:0050962)2.37626538
154spermatid nucleus differentiation (GO:0007289)2.34339956
155centriole assembly (GO:0098534)2.34193701
156postsynaptic membrane organization (GO:0001941)2.33225925
157microtubule severing (GO:0051013)2.26870745
158regulation of protein kinase A signaling (GO:0010738)2.26343933
159regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.25503591
160polyol catabolic process (GO:0046174)2.24332960
161GTP biosynthetic process (GO:0006183)2.22137387
162urinary tract smooth muscle contraction (GO:0014848)2.21130491
163mannosylation (GO:0097502)2.21091060
164positive regulation of CREB transcription factor activity (GO:0032793)2.20732536
165gamma-aminobutyric acid signaling pathway (GO:0007214)2.20249776
166negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.19958878
167protein-chromophore linkage (GO:0018298)2.18471916
168regulation of short-term neuronal synaptic plasticity (GO:0048172)2.17620291
169positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.17102735
170long-chain fatty acid biosynthetic process (GO:0042759)2.17040844
171chromosome organization involved in meiosis (GO:0070192)2.14903515
172nonmotile primary cilium assembly (GO:0035058)2.13453411
173mitochondrion degradation (GO:0000422)2.13204419

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99954357
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.59234764
3GBX2_23144817_ChIP-Seq_PC3_Human3.42871304
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45264452
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.45119593
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.37911221
7TAF15_26573619_Chip-Seq_HEK293_Human2.36617208
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35592891
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31123111
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.30836033
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.24750992
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21421067
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.15279845
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95292956
15GABP_17652178_ChIP-ChIP_JURKAT_Human1.91408774
16CBX2_27304074_Chip-Seq_ESCs_Mouse1.88867526
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.85847850
18VDR_22108803_ChIP-Seq_LS180_Human1.79325052
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.76751627
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74588699
21CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73110959
22P300_19829295_ChIP-Seq_ESCs_Human1.69573252
23* REST_21632747_ChIP-Seq_MESCs_Mouse1.69467969
24SUZ12_27294783_Chip-Seq_NPCs_Mouse1.66135369
25RNF2_27304074_Chip-Seq_NSC_Mouse1.63055988
26TP53_22573176_ChIP-Seq_HFKS_Human1.59935472
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58273856
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57282498
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57081888
30ZNF274_21170338_ChIP-Seq_K562_Hela1.57024039
31MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56354727
32SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56335908
33SMAD4_21799915_ChIP-Seq_A2780_Human1.55361187
34SMAD_19615063_ChIP-ChIP_OVARY_Human1.55078149
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.54904010
36IGF1R_20145208_ChIP-Seq_DFB_Human1.54459313
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53527416
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52854602
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52800381
40IRF1_19129219_ChIP-ChIP_H3396_Human1.52198964
41PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51901457
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51138589
43FUS_26573619_Chip-Seq_HEK293_Human1.49603149
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49589854
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49460224
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.48452885
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.48345194
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.48301822
49BCAT_22108803_ChIP-Seq_LS180_Human1.46252467
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43565203
51ER_23166858_ChIP-Seq_MCF-7_Human1.43543568
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43333923
53EZH2_27294783_Chip-Seq_NPCs_Mouse1.40389310
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.39229341
55EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39108329
56SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38037810
57EST1_17652178_ChIP-ChIP_JURKAT_Human1.37359976
58P53_22387025_ChIP-Seq_ESCs_Mouse1.35667872
59EZH2_27294783_Chip-Seq_ESCs_Mouse1.35638009
60MYC_18940864_ChIP-ChIP_HL60_Human1.35077529
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34989055
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34989055
63IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34363375
64SOX2_19829295_ChIP-Seq_ESCs_Human1.33672365
65NANOG_19829295_ChIP-Seq_ESCs_Human1.33672365
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32184169
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32116236
68SUZ12_18555785_Chip-Seq_ESCs_Mouse1.32012247
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30257001
70MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29148353
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.28738299
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.28506418
73KDM2B_26808549_Chip-Seq_REH_Human1.28038387
74GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27610283
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.27345551
76* FOXA1_25329375_ChIP-Seq_VCAP_Human1.27116660
77* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27116660
78STAT3_18555785_Chip-Seq_ESCs_Mouse1.26219648
79* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.24907462
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.24819908
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24366053
82P300_18555785_Chip-Seq_ESCs_Mouse1.24193837
83RNF2_27304074_Chip-Seq_ESCs_Mouse1.23971899
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23784609
85TCF4_22108803_ChIP-Seq_LS180_Human1.23270419
86MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23141551
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.22301370
88PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21237030
89SMAD4_21741376_ChIP-Seq_EPCs_Human1.20691714
90SCL_19346495_ChIP-Seq_HPC-7_Human1.20357058
91RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19883651
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19807789
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.19746286
94SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19396767
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.18877811
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18695039
97SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16985495
98KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16979361
99RUNX2_22187159_ChIP-Seq_PCA_Human1.15930085
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.15158796
101SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14689351
102NMYC_18555785_Chip-Seq_ESCs_Mouse1.14386790
103DROSHA_22980978_ChIP-Seq_HELA_Human1.14260731
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.13976189
105MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13804181
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13667740
107ELK1_19687146_ChIP-ChIP_HELA_Human1.13554751
108JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13191964
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13046986
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12736463
111NCOR_22424771_ChIP-Seq_293T_Human1.12097729
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.10924110
113CBP_20019798_ChIP-Seq_JUKART_Human1.10924110
114TCF4_23295773_ChIP-Seq_U87_Human1.10635025
115* AR_25329375_ChIP-Seq_VCAP_Human1.09019553
116EWS_26573619_Chip-Seq_HEK293_Human1.08927454
117* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08902403
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08787348
119* AR_20517297_ChIP-Seq_VCAP_Human1.08631429
120PU1_27457419_Chip-Seq_LIVER_Mouse1.08080623
121LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07888273
122EED_16625203_ChIP-ChIP_MESCs_Mouse1.07763583
123FLI1_21867929_ChIP-Seq_TH2_Mouse1.07225150
124* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06815192
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.06446047
126CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06311772
127VDR_23849224_ChIP-Seq_CD4+_Human1.05788498
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05742289
129HOXB7_26014856_ChIP-Seq_BT474_Human1.05186890
130CTCF_18555785_Chip-Seq_ESCs_Mouse1.04905651
131CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04592779
132OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04585864
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.04532122
134KLF4_18555785_Chip-Seq_ESCs_Mouse1.03989392
135TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03641224
136JUN_21703547_ChIP-Seq_K562_Human1.03206055
137PIAS1_25552417_ChIP-Seq_VCAP_Human1.03174764
138STAT3_23295773_ChIP-Seq_U87_Human1.03020039
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01053049
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97028658
141AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96582608
142CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96096462
143CDX2_22108803_ChIP-Seq_LS180_Human0.92259892

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.43896694
2MP0003880_abnormal_central_pattern3.11326337
3MP0006292_abnormal_olfactory_placode2.65146140
4MP0002736_abnormal_nociception_after2.65014118
5MP0005409_darkened_coat_color2.60123261
6MP0001968_abnormal_touch/_nociception2.59447537
7MP0003698_abnormal_male_reproductive2.58070982
8MP0004859_abnormal_synaptic_plasticity2.47661811
9MP0001188_hyperpigmentation2.43931424
10MP0000569_abnormal_digit_pigmentation2.42524424
11MP0009046_muscle_twitch2.42474047
12MP0008877_abnormal_DNA_methylation2.39207558
13MP0001929_abnormal_gametogenesis2.16999469
14MP0005646_abnormal_pituitary_gland2.15903216
15MP0009745_abnormal_behavioral_response2.11837778
16MP0003195_calcinosis2.11442050
17MP0002735_abnormal_chemical_nociception2.09864897
18MP0002272_abnormal_nervous_system2.08840605
19MP0003635_abnormal_synaptic_transmissio2.06812236
20MP0004147_increased_porphyrin_level2.06620113
21MP0003787_abnormal_imprinting2.02955578
22MP0002837_dystrophic_cardiac_calcinosis1.99908137
23MP0004885_abnormal_endolymph1.97548034
24MP0002638_abnormal_pupillary_reflex1.95473425
25MP0005645_abnormal_hypothalamus_physiol1.95048180
26MP0001486_abnormal_startle_reflex1.85063750
27MP0001502_abnormal_circadian_rhythm1.83525440
28MP0002064_seizures1.78904377
29MP0003646_muscle_fatigue1.77639339
30MP0008875_abnormal_xenobiotic_pharmacok1.74567984
31MP0008872_abnormal_physiological_respon1.72003965
32MP0000427_abnormal_hair_cycle1.71954308
33MP0002653_abnormal_ependyma_morphology1.70706880
34MP0006276_abnormal_autonomic_nervous1.69437712
35MP0005551_abnormal_eye_electrophysiolog1.69249735
36MP0005423_abnormal_somatic_nervous1.68529019
37MP0001984_abnormal_olfaction1.65126843
38MP0004270_analgesia1.64940705
39MP0001501_abnormal_sleep_pattern1.60488171
40MP0002063_abnormal_learning/memory/cond1.58689257
41MP0008569_lethality_at_weaning1.57888309
42MP0002938_white_spotting1.56642056
43MP0000015_abnormal_ear_pigmentation1.54667706
44MP0002734_abnormal_mechanical_nocicepti1.52980930
45MP0002067_abnormal_sensory_capabilities1.52357707
46MP0002928_abnormal_bile_duct1.50170133
47MP0002572_abnormal_emotion/affect_behav1.49505534
48MP0001986_abnormal_taste_sensitivity1.46039939
49MP0003136_yellow_coat_color1.45501336
50MP0005671_abnormal_response_to1.43448243
51MP0002210_abnormal_sex_determination1.42729859
52MP0001485_abnormal_pinna_reflex1.42181514
53MP0004043_abnormal_pH_regulation1.40874467
54MP0002102_abnormal_ear_morphology1.38604401
55MP0004142_abnormal_muscle_tone1.36854942
56MP0000372_irregular_coat_pigmentation1.30060764
57MP0002161_abnormal_fertility/fecundity1.29050495
58MP0001905_abnormal_dopamine_level1.27172522
59MP0005084_abnormal_gallbladder_morpholo1.26205596
60MP0001440_abnormal_grooming_behavior1.25926721
61MP0005174_abnormal_tail_pigmentation1.24505747
62MP0005389_reproductive_system_phenotype1.24084825
63MP0005075_abnormal_melanosome_morpholog1.23646298
64MP0002822_catalepsy1.22044577
65MP0003718_maternal_effect1.21363458
66MP0004742_abnormal_vestibular_system1.20749104
67MP0004133_heterotaxia1.20288951
68MP0001529_abnormal_vocalization1.20196036
69MP0008789_abnormal_olfactory_epithelium1.17574464
70MP0002876_abnormal_thyroid_physiology1.15896771
71MP0010386_abnormal_urinary_bladder1.15437610
72MP0004145_abnormal_muscle_electrophysio1.11628308
73MP0001970_abnormal_pain_threshold1.10374833
74MP0008995_early_reproductive_senescence1.10062276
75MP0005171_absent_coat_pigmentation1.07109419
76MP0003121_genomic_imprinting1.04944427
77MP0001764_abnormal_homeostasis1.04084437
78MP0005670_abnormal_white_adipose1.03727353
79MP0000778_abnormal_nervous_system1.02925494
80MP0002557_abnormal_social/conspecific_i1.01548310
81MP0008058_abnormal_DNA_repair0.99761853
82MP0002733_abnormal_thermal_nociception0.99736431
83MP0002184_abnormal_innervation0.98981838
84MP0001145_abnormal_male_reproductive0.98089720
85MP0002277_abnormal_respiratory_mucosa0.98061182
86MP0000653_abnormal_sex_gland0.97806512
87MP0000955_abnormal_spinal_cord0.96766597
88MP0005253_abnormal_eye_physiology0.94538650
89MP0000920_abnormal_myelination0.92573751
90MP0003943_abnormal_hepatobiliary_system0.92213386
91MP0006072_abnormal_retinal_apoptosis0.91919476
92MP0000631_abnormal_neuroendocrine_gland0.90918176
93MP0002751_abnormal_autonomic_nervous0.90686887
94MP0002095_abnormal_skin_pigmentation0.89823821
95MP0003950_abnormal_plasma_membrane0.89747601
96MP0001919_abnormal_reproductive_system0.89723855
97MP0005377_hearing/vestibular/ear_phenot0.89212883
98MP0003878_abnormal_ear_physiology0.89212883
99MP0003122_maternal_imprinting0.87517710
100MP0005386_behavior/neurological_phenoty0.87239281
101MP0004924_abnormal_behavior0.87239281
102MP0002163_abnormal_gland_morphology0.86969359
103MP0002229_neurodegeneration0.85985643
104MP0002882_abnormal_neuron_morphology0.84943060
105MP0003763_abnormal_thymus_physiology0.84777486
106MP0002160_abnormal_reproductive_system0.84658038
107MP0002752_abnormal_somatic_nervous0.83542089
108MP0001835_abnormal_antigen_presentation0.83082012
109MP0003937_abnormal_limbs/digits/tail_de0.80810448
110MP0001293_anophthalmia0.80699638
111MP0003633_abnormal_nervous_system0.80526160
112MP0008775_abnormal_heart_ventricle0.80013889
113MP0002132_abnormal_respiratory_system0.79383658
114MP0001963_abnormal_hearing_physiology0.79194673
115MP0004134_abnormal_chest_morphology0.77933554
116MP0003119_abnormal_digestive_system0.77019832
117MP0000383_abnormal_hair_follicle0.76684755
118MP0003567_abnormal_fetal_cardiomyocyte0.76451673
119MP0004215_abnormal_myocardial_fiber0.75220378
120MP0003879_abnormal_hair_cell0.73950327
121MP0002066_abnormal_motor_capabilities/c0.73345587
122MP0004811_abnormal_neuron_physiology0.71604942
123MP0004381_abnormal_hair_follicle0.71312142
124MP0002009_preneoplasia0.71113564
125MP0001324_abnormal_eye_pigmentation0.70367501
126MP0003183_abnormal_peptide_metabolism0.67773518
127MP0003724_increased_susceptibility_to0.66260218
128MP0005379_endocrine/exocrine_gland_phen0.64770747
129MP0003631_nervous_system_phenotype0.63072184
130MP0000026_abnormal_inner_ear0.61891927
131MP0004808_abnormal_hematopoietic_stem0.61604417
132MP0009785_altered_susceptibility_to0.60965719
133MP0002234_abnormal_pharynx_morphology0.58196158
134MP0003011_delayed_dark_adaptation0.55644100
135MP0001851_eye_inflammation0.55262987
136MP0005195_abnormal_posterior_eye0.54317689

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.18916675
2Absent/shortened dynein arms (HP:0200106)8.18916675
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.35244414
4Abnormal respiratory epithelium morphology (HP:0012253)6.36358118
5Abnormal respiratory motile cilium morphology (HP:0005938)6.36358118
6Abnormal respiratory motile cilium physiology (HP:0012261)5.85432232
7Abnormal ciliary motility (HP:0012262)5.35239651
8Rhinitis (HP:0012384)4.59620594
9Focal motor seizures (HP:0011153)3.69269675
10Infertility (HP:0000789)3.38797191
11Progressive inability to walk (HP:0002505)3.26599556
12Nephronophthisis (HP:0000090)3.22233530
13Type II lissencephaly (HP:0007260)3.18833778
14Medial flaring of the eyebrow (HP:0010747)3.17130947
15Nasal polyposis (HP:0100582)3.08940483
16Febrile seizures (HP:0002373)3.07811598
17Chronic bronchitis (HP:0004469)2.94134943
18Molar tooth sign on MRI (HP:0002419)2.92411717
19Abnormality of midbrain morphology (HP:0002418)2.92411717
20True hermaphroditism (HP:0010459)2.91272669
21Abnormality of the renal cortex (HP:0011035)2.90458364
22Recurrent sinusitis (HP:0011108)2.84883581
23Bronchiectasis (HP:0002110)2.82097807
24Bronchitis (HP:0012387)2.74099683
25Abnormality of the renal medulla (HP:0100957)2.63124002
26Chronic sinusitis (HP:0011109)2.61456273
27Recurrent bronchitis (HP:0002837)2.60742842
28Cystic liver disease (HP:0006706)2.60729855
29Congenital stationary night blindness (HP:0007642)2.59899826
30Abnormality of alanine metabolism (HP:0010916)2.58139012
31Hyperalaninemia (HP:0003348)2.58139012
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58139012
33Pancreatic fibrosis (HP:0100732)2.57947242
34Tubulointerstitial nephritis (HP:0001970)2.53019374
35Epileptic encephalopathy (HP:0200134)2.52808064
36Mitochondrial inheritance (HP:0001427)2.50931196
37Abolished electroretinogram (ERG) (HP:0000550)2.50532036
38Gait imbalance (HP:0002141)2.50158948
39Acute necrotizing encephalopathy (HP:0006965)2.49025755
40Retinal dysplasia (HP:0007973)2.47618044
41Large for gestational age (HP:0001520)2.46239422
42Hypothermia (HP:0002045)2.45389179
43Type 2 muscle fiber atrophy (HP:0003554)2.45286077
44Atonic seizures (HP:0010819)2.43885609
45Sclerocornea (HP:0000647)2.43261890
46Congenital primary aphakia (HP:0007707)2.42485121
47Increased CSF lactate (HP:0002490)2.39468696
48Hepatocellular necrosis (HP:0001404)2.38871029
49Hyperventilation (HP:0002883)2.38582306
50Cerebellar dysplasia (HP:0007033)2.37442748
51Abnormality of the nasal mucosa (HP:0000433)2.36837668
52Pendular nystagmus (HP:0012043)2.35027645
53Gaze-evoked nystagmus (HP:0000640)2.34799229
54Nephrogenic diabetes insipidus (HP:0009806)2.32721679
55Decreased central vision (HP:0007663)2.31931188
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.30923573
57Tubular atrophy (HP:0000092)2.29957394
58Progressive cerebellar ataxia (HP:0002073)2.29231592
59Congenital, generalized hypertrichosis (HP:0004540)2.27920685
60Lissencephaly (HP:0001339)2.27740290
61Anencephaly (HP:0002323)2.27701951
62Inability to walk (HP:0002540)2.27484434
63Poor coordination (HP:0002370)2.27452929
64Bony spicule pigmentary retinopathy (HP:0007737)2.26469749
65Nonprogressive disorder (HP:0003680)2.24091604
66Abnormality of the pons (HP:0007361)2.20066631
67Increased corneal curvature (HP:0100692)2.19983656
68Keratoconus (HP:0000563)2.19983656
69Progressive macrocephaly (HP:0004481)2.19761697
70Hepatic necrosis (HP:0002605)2.17429330
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.17152440
72Postaxial foot polydactyly (HP:0001830)2.15600822
73Oligodactyly (hands) (HP:0001180)2.14074217
74Aplasia/Hypoplasia of the lens (HP:0008063)2.12107847
75Abnormal hair whorl (HP:0010721)2.11754403
76Abnormal mitochondria in muscle tissue (HP:0008316)2.10272030
77Lipid accumulation in hepatocytes (HP:0006561)2.09707491
78Chronic hepatic failure (HP:0100626)2.08821860
79Concave nail (HP:0001598)2.08319912
80Chorioretinal atrophy (HP:0000533)2.07492601
81Recurrent otitis media (HP:0000403)2.07197232
82Aplastic anemia (HP:0001915)2.06710713
83Focal seizures (HP:0007359)2.06661629
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06153661
85Furrowed tongue (HP:0000221)2.06098453
86Acute encephalopathy (HP:0006846)2.06009115
87Polyuria (HP:0000103)2.02813875
88Abnormality of DNA repair (HP:0003254)2.00149410
89Severe muscular hypotonia (HP:0006829)1.99723309
90Short tibia (HP:0005736)1.99107292
91Hypoplasia of the pons (HP:0012110)1.97988127
92Optic nerve hypoplasia (HP:0000609)1.96942827
93Weak cry (HP:0001612)1.93827107
94Methylmalonic acidemia (HP:0002912)1.93581988
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90990370
96Aplasia/Hypoplasia of the patella (HP:0006498)1.88822899
97Retrobulbar optic neuritis (HP:0100654)1.88748424
98Optic neuritis (HP:0100653)1.88748424
99Optic disc pallor (HP:0000543)1.88535747
100Aplasia/Hypoplasia of the spleen (HP:0010451)1.88022484
101Patellar aplasia (HP:0006443)1.87911208
102Severe visual impairment (HP:0001141)1.87877217
103Gonadotropin excess (HP:0000837)1.87395820
104Genital tract atresia (HP:0001827)1.86795672
105Hemiparesis (HP:0001269)1.85959060
106Aplasia/hypoplasia of the uterus (HP:0008684)1.84582046
107Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82537523
108Abnormal protein N-linked glycosylation (HP:0012347)1.82537523
109Abnormal protein glycosylation (HP:0012346)1.82537523
110Abnormal glycosylation (HP:0012345)1.82537523
111Vaginal atresia (HP:0000148)1.81479310
112Muscle fiber atrophy (HP:0100295)1.81262966
113Bile duct proliferation (HP:0001408)1.81181542
114Abnormal biliary tract physiology (HP:0012439)1.81181542
115Pancreatic cysts (HP:0001737)1.80668743
116Renal cortical cysts (HP:0000803)1.79997907
117Abnormal rod and cone electroretinograms (HP:0008323)1.79975129
118Increased hepatocellular lipid droplets (HP:0006565)1.76860758
119Pachygyria (HP:0001302)1.76180855
120Clubbing of toes (HP:0100760)1.75340565
121Congenital sensorineural hearing impairment (HP:0008527)1.74952798
122Protruding tongue (HP:0010808)1.74326022
123Fair hair (HP:0002286)1.74221887
124Small hand (HP:0200055)1.74195015
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.73684551
126Supernumerary spleens (HP:0009799)1.73010109
127Astigmatism (HP:0000483)1.72252426
128Fatigable weakness (HP:0003473)1.70288867
129Abnormality of the neuromuscular junction (HP:0003398)1.70288867
130Choroideremia (HP:0001139)1.69770230
131Median cleft lip (HP:0000161)1.67396381
132Postaxial hand polydactyly (HP:0001162)1.66094231
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.66083861
134Congenital hepatic fibrosis (HP:0002612)1.63915841
135Abnormality of the preputium (HP:0100587)1.63729847
136Abnormality of macular pigmentation (HP:0008002)1.63119572
137Abnormality of molar morphology (HP:0011070)1.62427832
138Abnormality of molar (HP:0011077)1.62427832
139Meckel diverticulum (HP:0002245)1.61184114
140Abnormal drinking behavior (HP:0030082)1.59670508
141Polydipsia (HP:0001959)1.59670508
142Absent frontal sinuses (HP:0002688)1.59359738
143Abnormality of the dental root (HP:0006486)1.58221319
144Taurodontia (HP:0000679)1.58221319
145Abnormality of permanent molar morphology (HP:0011071)1.58221319
146Attenuation of retinal blood vessels (HP:0007843)1.57633541
147Broad-based gait (HP:0002136)1.57303704
148Enlarged kidneys (HP:0000105)1.57229212
149Abnormality of incisor morphology (HP:0011063)1.57119215
150Abnormality of the ileum (HP:0001549)1.56008177
151Anomalous pulmonary venous return (HP:0010772)1.54461148
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.54380891
153Abnormality of renal resorption (HP:0011038)1.53892559
154Chronic otitis media (HP:0000389)1.53678851
155Renal Fanconi syndrome (HP:0001994)1.52947938
156Male pseudohermaphroditism (HP:0000037)1.52777247
157Chromosomal breakage induced by crosslinking agents (HP:0003221)1.51712063
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.50599792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.95773376
2MUSK4.37206276
3TNIK4.13246022
4PDK43.49161722
5PDK33.49161722
6MKNK22.81213310
7CASK2.62402282
8MAP4K22.58825212
9PDK22.31897852
10GRK12.27465210
11GRK72.22148092
12MAP2K72.21284986
13MAPKAPK52.21053276
14NTRK21.94243701
15TAOK31.89428226
16NTRK31.86587288
17MAPK131.86046574
18ADRBK21.83320404
19MKNK11.77915370
20SIK31.74444249
21TLK11.70189331
22ACVR1B1.69005840
23MAP3K121.62705196
24NEK61.60518242
25TXK1.59581922
26STK391.54046711
27PINK11.51473186
28FGFR21.47499875
29PAK31.43744570
30DYRK21.40507457
31FES1.37062660
32TRIM281.36913995
33PRPF4B1.34721245
34PRKD31.31747336
35TNK21.26518861
36STK161.19114104
37BCKDK1.12955859
38YES11.11222388
39TEC1.10608260
40BMPR21.09727768
41CLK11.09684959
42DYRK1A1.08986892
43PLK21.07948710
44WEE11.07099262
45CDK31.05915087
46MAP3K141.04491745
47PTK2B1.04431530
48MAP2K61.02107763
49WNK11.02046588
50CDK191.00284142
51INSRR0.97615296
52VRK10.97500054
53DAPK20.95576330
54RIPK40.95471905
55MAPK150.95021422
56WNK40.94030143
57EIF2AK30.93266106
58CAMK10.92158575
59SRPK10.90411109
60NME10.90106980
61PHKG20.87939771
62PHKG10.87939771
63EPHA40.86588878
64TYRO30.85790462
65BRSK20.84992604
66STK38L0.83960149
67BUB10.82968180
68ERBB30.82481873
69MAP3K60.82063300
70ICK0.81475058
71KIT0.81078534
72PRKCI0.79327156
73MARK20.77689275
74TRPM70.77648267
75PNCK0.74929873
76IKBKE0.74283837
77CSNK1G10.72319346
78CAMK2A0.72189040
79SYK0.71939500
80ZAP700.71738426
81CAMK2B0.70055517
82FLT30.69811923
83EPHA30.69743854
84BMPR1B0.69677570
85BCR0.68856767
86BTK0.66978216
87PLK40.65930451
88PLK30.65309639
89CCNB10.64865985
90WNK30.64370254
91NUAK10.64089189
92SGK20.63995079
93TESK10.63834162
94OXSR10.61864305
95MINK10.60311508
96PDK10.59789873
97NEK20.58921897
98ZAK0.58637898
99ITK0.58152251
100CAMKK20.57241617
101PKN10.56973554
102PIK3CA0.56169803
103PRKCG0.56151524
104IRAK10.56009137
105STK30.55908374
106SIK20.55545905
107SGK2230.55178299
108SGK4940.55178299
109TGFBR10.54631807
110MST40.54593391
111MARK10.53009048
112CSNK1A10.52653633
113CSNK1G20.52065960
114TIE10.51269140
115MAP3K130.51022000
116IRAK40.50760815
117MAP4K10.48827273
118STK380.48535022
119MAP2K40.48111589
120PLK10.47858445
121FGFR40.47034124
122PRKACA0.45671285
123MAP3K40.45527767
124CAMK2D0.45287858
125FGFR30.44997112
126STK110.44868265
127NLK0.43991896
128CSNK1G30.43206260
129VRK20.43167648
130PRKCE0.42790645
131ADRBK10.42765485
132UHMK10.42510350
133PRKCQ0.42301980
134LYN0.40502844
135PRKCH0.40083979
136CAMK2G0.39999280
137HCK0.39736882
138IKBKB0.37477665
139CSNK1A1L0.36540483
140MARK30.34563952
141PRKG10.33050593
142LIMK10.33034573
143CHEK20.32317960
144RPS6KA50.31325579
145EIF2AK20.30989153
146PRKCZ0.30286216
147GRK50.30200327

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57972805
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72461215
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28522456
4Circadian entrainment_Homo sapiens_hsa047132.20554538
5Nitrogen metabolism_Homo sapiens_hsa009102.19577592
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.17119351
7Morphine addiction_Homo sapiens_hsa050322.15466119
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.11724796
9Homologous recombination_Homo sapiens_hsa034402.11431644
10Butanoate metabolism_Homo sapiens_hsa006502.09853521
11Taste transduction_Homo sapiens_hsa047422.08711655
12Glutamatergic synapse_Homo sapiens_hsa047242.05204194
13Selenocompound metabolism_Homo sapiens_hsa004501.99938949
14Phototransduction_Homo sapiens_hsa047441.98456960
15RNA polymerase_Homo sapiens_hsa030201.95982211
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93953344
17Fanconi anemia pathway_Homo sapiens_hsa034601.86308643
18Olfactory transduction_Homo sapiens_hsa047401.83726707
19Serotonergic synapse_Homo sapiens_hsa047261.79944863
20Basal transcription factors_Homo sapiens_hsa030221.79329262
21Amphetamine addiction_Homo sapiens_hsa050311.77945665
22GABAergic synapse_Homo sapiens_hsa047271.75713966
23Calcium signaling pathway_Homo sapiens_hsa040201.66097508
24Synaptic vesicle cycle_Homo sapiens_hsa047211.64110635
25Primary immunodeficiency_Homo sapiens_hsa053401.59296464
26Long-term potentiation_Homo sapiens_hsa047201.54320316
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.53206942
28Circadian rhythm_Homo sapiens_hsa047101.52577194
29Renin secretion_Homo sapiens_hsa049241.48851040
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48597344
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42730194
32Salivary secretion_Homo sapiens_hsa049701.41966898
33Proteasome_Homo sapiens_hsa030501.33644557
34Caffeine metabolism_Homo sapiens_hsa002321.31913895
35Tryptophan metabolism_Homo sapiens_hsa003801.31198968
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.27319422
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21990348
38Dopaminergic synapse_Homo sapiens_hsa047281.21635255
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.20447824
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.20273362
41Cardiac muscle contraction_Homo sapiens_hsa042601.19883223
42Propanoate metabolism_Homo sapiens_hsa006401.18783702
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18084060
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17859390
45Long-term depression_Homo sapiens_hsa047301.17392121
46Cocaine addiction_Homo sapiens_hsa050301.13046378
47Sphingolipid metabolism_Homo sapiens_hsa006001.12666850
48Insulin secretion_Homo sapiens_hsa049111.12612968
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11468158
50Autoimmune thyroid disease_Homo sapiens_hsa053201.10789689
51Peroxisome_Homo sapiens_hsa041461.08924184
52Ether lipid metabolism_Homo sapiens_hsa005651.08745518
53Huntingtons disease_Homo sapiens_hsa050161.07994277
54cAMP signaling pathway_Homo sapiens_hsa040241.06541355
55Non-homologous end-joining_Homo sapiens_hsa034501.01348100
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00084876
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00055392
58Inositol phosphate metabolism_Homo sapiens_hsa005621.00013945
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.96790007
60Oxytocin signaling pathway_Homo sapiens_hsa049210.95829264
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94892609
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.94313593
63Purine metabolism_Homo sapiens_hsa002300.93515281
64Rheumatoid arthritis_Homo sapiens_hsa053230.92866390
65Cholinergic synapse_Homo sapiens_hsa047250.91688869
66Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91352448
67Gastric acid secretion_Homo sapiens_hsa049710.90322481
68Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90126117
69Allograft rejection_Homo sapiens_hsa053300.89852200
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89146047
71Chemical carcinogenesis_Homo sapiens_hsa052040.87039339
72Linoleic acid metabolism_Homo sapiens_hsa005910.86870177
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86657942
74Collecting duct acid secretion_Homo sapiens_hsa049660.86051418
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84456168
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83787726
77Oxidative phosphorylation_Homo sapiens_hsa001900.82396166
78Dorso-ventral axis formation_Homo sapiens_hsa043200.81957819
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81784226
80Alzheimers disease_Homo sapiens_hsa050100.81690715
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80817882
82RNA degradation_Homo sapiens_hsa030180.80756159
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.79801278
84Arachidonic acid metabolism_Homo sapiens_hsa005900.78210136
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.77246350
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77080191
87Axon guidance_Homo sapiens_hsa043600.76981807
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76365650
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74957968
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74952180
91Hematopoietic cell lineage_Homo sapiens_hsa046400.74468956
92Protein export_Homo sapiens_hsa030600.74193937
93Pyrimidine metabolism_Homo sapiens_hsa002400.72940062
94Parkinsons disease_Homo sapiens_hsa050120.70773515
95African trypanosomiasis_Homo sapiens_hsa051430.70633460
96Sulfur metabolism_Homo sapiens_hsa009200.68627565
97Glycerolipid metabolism_Homo sapiens_hsa005610.68403595
98Measles_Homo sapiens_hsa051620.68003561
99One carbon pool by folate_Homo sapiens_hsa006700.67786499
100MAPK signaling pathway_Homo sapiens_hsa040100.67778549
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67455591
102Ovarian steroidogenesis_Homo sapiens_hsa049130.66458403
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65815144
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65090934
105cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64352994
106Ras signaling pathway_Homo sapiens_hsa040140.63311418
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.63158679
108Graft-versus-host disease_Homo sapiens_hsa053320.60624095
109Metabolic pathways_Homo sapiens_hsa011000.60220796
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59980349
111Retinol metabolism_Homo sapiens_hsa008300.57281254
112T cell receptor signaling pathway_Homo sapiens_hsa046600.56559917
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56324776
114Malaria_Homo sapiens_hsa051440.54739933
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54682235
116Wnt signaling pathway_Homo sapiens_hsa043100.53607836
117Glucagon signaling pathway_Homo sapiens_hsa049220.53450291
118beta-Alanine metabolism_Homo sapiens_hsa004100.53325403
119Regulation of autophagy_Homo sapiens_hsa041400.52240055
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50789195
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50079568
122Nucleotide excision repair_Homo sapiens_hsa034200.50059935
123Type I diabetes mellitus_Homo sapiens_hsa049400.49606698
124Hedgehog signaling pathway_Homo sapiens_hsa043400.48970273
125Pancreatic secretion_Homo sapiens_hsa049720.48216204
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.48065009
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.47174226
128Asthma_Homo sapiens_hsa053100.46376773
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45367430
130ABC transporters_Homo sapiens_hsa020100.45101902
131Steroid biosynthesis_Homo sapiens_hsa001000.44516619
132Alcoholism_Homo sapiens_hsa050340.43269885
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40338718
134Mineral absorption_Homo sapiens_hsa049780.40201934
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.38982321
136Sulfur relay system_Homo sapiens_hsa041220.38137866
137RNA transport_Homo sapiens_hsa030130.38105393
138Fatty acid elongation_Homo sapiens_hsa000620.37968872
139Fatty acid biosynthesis_Homo sapiens_hsa000610.37169277
140Folate biosynthesis_Homo sapiens_hsa007900.36706704
141Fat digestion and absorption_Homo sapiens_hsa049750.35986248
142p53 signaling pathway_Homo sapiens_hsa041150.33983689
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.27325872
144Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25268445

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