LEO1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)4.60524146
2nucleobase biosynthetic process (GO:0046112)4.50971074
3purine nucleobase biosynthetic process (GO:0009113)4.47644490
4formation of translation preinitiation complex (GO:0001731)4.39566873
5ribosome assembly (GO:0042255)4.27290995
6ribosome biogenesis (GO:0042254)4.20683730
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.99192060
8DNA replication initiation (GO:0006270)3.96166884
9regulation of centriole replication (GO:0046599)3.94067404
10metaphase plate congression (GO:0051310)3.86479006
11DNA replication checkpoint (GO:0000076)3.86420947
12replication fork processing (GO:0031297)3.81150155
13proteasome assembly (GO:0043248)3.79910467
14protein localization to kinetochore (GO:0034501)3.76346289
15nuclear pore organization (GO:0006999)3.75281932
16maturation of SSU-rRNA (GO:0030490)3.74268845
17mitotic nuclear envelope disassembly (GO:0007077)3.71388057
18DNA strand elongation involved in DNA replication (GO:0006271)3.71203602
19spliceosomal snRNP assembly (GO:0000387)3.70983882
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.68633090
21DNA unwinding involved in DNA replication (GO:0006268)3.66098856
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64536864
23cullin deneddylation (GO:0010388)3.62712988
24ribonucleoprotein complex biogenesis (GO:0022613)3.62553094
25DNA replication-dependent nucleosome organization (GO:0034723)3.62473604
26DNA replication-dependent nucleosome assembly (GO:0006335)3.62473604
27viral mRNA export from host cell nucleus (GO:0046784)3.62429896
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.58909189
29CENP-A containing nucleosome assembly (GO:0034080)3.58706645
30DNA damage response, detection of DNA damage (GO:0042769)3.57387813
31positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.56868247
327-methylguanosine mRNA capping (GO:0006370)3.53453135
33regulation of spindle organization (GO:0090224)3.52282454
34chromatin remodeling at centromere (GO:0031055)3.51984196
35DNA strand elongation (GO:0022616)3.50968906
36RNA capping (GO:0036260)3.49410697
377-methylguanosine RNA capping (GO:0009452)3.49410697
38nuclear envelope disassembly (GO:0051081)3.44264364
39membrane disassembly (GO:0030397)3.44264364
40attachment of spindle microtubules to kinetochore (GO:0008608)3.41501692
41kinetochore organization (GO:0051383)3.39445859
42negative regulation of ligase activity (GO:0051352)3.38731186
43negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38731186
44establishment of chromosome localization (GO:0051303)3.38043193
45rRNA processing (GO:0006364)3.37662774
46negative regulation of chromosome segregation (GO:0051985)3.35752330
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.35589291
48negative regulation of sister chromatid segregation (GO:0033046)3.35589291
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.35589291
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.35589291
51telomere maintenance via semi-conservative replication (GO:0032201)3.30680089
52protein deneddylation (GO:0000338)3.30275524
53mitotic spindle assembly checkpoint (GO:0007094)3.29463031
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.29388712
55negative regulation of DNA-dependent DNA replication (GO:2000104)3.29354694
56establishment of integrated proviral latency (GO:0075713)3.28928942
57spindle checkpoint (GO:0031577)3.28052139
58rRNA metabolic process (GO:0016072)3.27499496
59spindle assembly checkpoint (GO:0071173)3.27366357
60rRNA modification (GO:0000154)3.26890969
61energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26297225
62ATP synthesis coupled proton transport (GO:0015986)3.26297225
63DNA replication-independent nucleosome organization (GO:0034724)3.26247416
64DNA replication-independent nucleosome assembly (GO:0006336)3.26247416
65DNA double-strand break processing (GO:0000729)3.25089547
66ribosomal large subunit biogenesis (GO:0042273)3.25041751
67mitotic sister chromatid segregation (GO:0000070)3.24978080
68IMP biosynthetic process (GO:0006188)3.23744601
69mitotic spindle checkpoint (GO:0071174)3.23727597
70transcription elongation from RNA polymerase I promoter (GO:0006362)3.23494335
71maturation of 5.8S rRNA (GO:0000460)3.22605279
72transcription-coupled nucleotide-excision repair (GO:0006283)3.21985001
73positive regulation of chromosome segregation (GO:0051984)3.21734910
74histone exchange (GO:0043486)3.20656789
75nuclear pore complex assembly (GO:0051292)3.19519580
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.18269681
77resolution of meiotic recombination intermediates (GO:0000712)3.17579602
78protein-cofactor linkage (GO:0018065)3.16964758
79transcription elongation from RNA polymerase III promoter (GO:0006385)3.16795776
80termination of RNA polymerase III transcription (GO:0006386)3.16795776
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16487077
82spliceosomal complex assembly (GO:0000245)3.15730365
83chaperone-mediated protein transport (GO:0072321)3.14468552
84termination of RNA polymerase I transcription (GO:0006363)3.13362381
85regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13227025
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12129862
87kinetochore assembly (GO:0051382)3.11134260
88telomere maintenance via recombination (GO:0000722)3.10770422
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.10720098
90DNA deamination (GO:0045006)3.10485959
91establishment of protein localization to mitochondrial membrane (GO:0090151)3.09859449
92protein localization to chromosome, centromeric region (GO:0071459)3.09304343
93regulation of mitotic sister chromatid separation (GO:0010965)3.08088023
94regulation of mitotic sister chromatid segregation (GO:0033047)3.08088023
95regulation of sister chromatid segregation (GO:0033045)3.08088023
96somatic hypermutation of immunoglobulin genes (GO:0016446)3.06143977
97somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06143977
98folic acid-containing compound biosynthetic process (GO:0009396)3.04873581
99regulation of chromosome segregation (GO:0051983)3.04361681
100mitotic recombination (GO:0006312)3.04119761
101DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04036911
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.04008077
103cell cycle G1/S phase transition (GO:0044843)3.03787147
104G1/S transition of mitotic cell cycle (GO:0000082)3.03787147
105regulation of centrosome cycle (GO:0046605)3.03346927
106RNA splicing, via transesterification reactions (GO:0000375)3.02529572
107regulation of mitotic spindle checkpoint (GO:1903504)3.01201487
108regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.01201487
109transcription from RNA polymerase I promoter (GO:0006360)3.00714861
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.00580741
111signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.00580741
112positive regulation of ligase activity (GO:0051351)3.00232535
113signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00119924
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00119924
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00119924
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.99959375
117signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99959375
118mitochondrial respiratory chain complex assembly (GO:0033108)2.96934674
119ubiquinone biosynthetic process (GO:0006744)2.95734111
120protein complex biogenesis (GO:0070271)2.92656739
121centriole replication (GO:0007099)2.90625437
122ubiquinone metabolic process (GO:0006743)2.87714895
123exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85552369
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83185430
125organelle disassembly (GO:1903008)2.82783640
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82690029
127mitochondrial respiratory chain complex I assembly (GO:0032981)2.82690029
128NADH dehydrogenase complex assembly (GO:0010257)2.82690029
129response to pheromone (GO:0019236)2.81987390
130mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.79822559
131regulation of DNA endoreduplication (GO:0032875)2.76945872
132transcription initiation from RNA polymerase I promoter (GO:0006361)2.75919265
133regulation of mitochondrial translation (GO:0070129)2.71684343
134DNA catabolic process, exonucleolytic (GO:0000738)2.71609325
135mitotic sister chromatid cohesion (GO:0007064)2.70645880
136water-soluble vitamin biosynthetic process (GO:0042364)2.68865077
137DNA ligation (GO:0006266)2.68718073
138histone mRNA metabolic process (GO:0008334)2.68570265
139respiratory electron transport chain (GO:0022904)2.67914247
140pseudouridine synthesis (GO:0001522)2.67145372
141electron transport chain (GO:0022900)2.65798592
142regulation of cellular amino acid metabolic process (GO:0006521)2.63826526
143rRNA methylation (GO:0031167)2.63537090
144behavioral response to nicotine (GO:0035095)2.62945558
145respiratory chain complex IV assembly (GO:0008535)2.62804388
146negative regulation of DNA recombination (GO:0045910)2.61951290
147regulation of nuclear cell cycle DNA replication (GO:0033262)2.60515234
148ribosomal small subunit assembly (GO:0000028)2.59789585
149protein K6-linked ubiquitination (GO:0085020)2.59475127
150DNA-templated transcription, termination (GO:0006353)2.58862119
151RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58529690
152L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.58244270
153cellular component biogenesis (GO:0044085)2.56084343
154regulation of centrosome duplication (GO:0010824)2.56053301
155hindbrain development (GO:0030902)2.51939243
156postreplication repair (GO:0006301)2.51467018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.87254954
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51932312
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95120084
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.55479964
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51613692
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.43452620
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.42655800
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.37329681
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.36183430
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33753188
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.20663416
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.14662158
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.05887902
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95710365
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.93046300
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91554303
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.81895358
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72441335
19ZNF274_21170338_ChIP-Seq_K562_Hela2.64849232
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.57817545
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55500836
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.53418925
23XRN2_22483619_ChIP-Seq_HELA_Human2.47686553
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.43903162
25VDR_23849224_ChIP-Seq_CD4+_Human2.41365651
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.35606624
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.25738684
28DCP1A_22483619_ChIP-Seq_HELA_Human2.20133122
29* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.19431735
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18232924
31AR_21909140_ChIP-Seq_LNCAP_Human2.17958433
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16927790
33FOXP3_21729870_ChIP-Seq_TREG_Human2.13054087
34VDR_22108803_ChIP-Seq_LS180_Human2.13036466
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10688623
36EWS_26573619_Chip-Seq_HEK293_Human2.10083697
37GABP_19822575_ChIP-Seq_HepG2_Human2.07655062
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07576469
39MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03961876
40TTF2_22483619_ChIP-Seq_HELA_Human1.98520511
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95627678
42FUS_26573619_Chip-Seq_HEK293_Human1.91050159
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.90875883
44ELK1_19687146_ChIP-ChIP_HELA_Human1.86841164
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83724985
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81851790
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.80913432
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79970350
49SALL1_21062744_ChIP-ChIP_HESCs_Human1.76464636
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.69471371
51TAF15_26573619_Chip-Seq_HEK293_Human1.67214904
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65854100
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61620401
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60699995
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.60110095
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57498073
57CIITA_25753668_ChIP-Seq_RAJI_Human1.57316262
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.56571802
59* SRF_21415370_ChIP-Seq_HL-1_Mouse1.56477311
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55561719
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54053277
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.52974330
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52140902
64IGF1R_20145208_ChIP-Seq_DFB_Human1.50866955
65IRF1_19129219_ChIP-ChIP_H3396_Human1.50700330
66KDM5A_27292631_Chip-Seq_BREAST_Human1.49731810
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46134547
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46132395
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.45141173
70* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44279096
71MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43979497
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41209028
73GBX2_23144817_ChIP-Seq_PC3_Human1.40492418
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38689503
75POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38430891
76* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33405011
77HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30195032
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28523595
79P300_19829295_ChIP-Seq_ESCs_Human1.28388381
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26564282
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.25880219
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24921772
83CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23674805
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22706637
85PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20263528
86* ER_23166858_ChIP-Seq_MCF-7_Human1.19748738
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.18262721
88KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16104715
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15172733
90NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14812630
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14145830
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.13723107
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12037096
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10754439
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08283353
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06888742
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.06171593
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05628556
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05626686
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05224454
101SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05061591
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04712020
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04463983
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04288346
105TFEB_21752829_ChIP-Seq_HELA_Human1.04081588
106STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02535179
107KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98942698
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98942698
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98942698
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98857764
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97768606
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96980511
113SOX17_20123909_ChIP-Seq_XEN_Mouse0.96962185
114MYC_18940864_ChIP-ChIP_HL60_Human0.95855418
115* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95578894
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94951904
117SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93608838
118PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93022058
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92654723
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92309837
121NOTCH1_21737748_ChIP-Seq_TLL_Human0.91375003
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90900320
123CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90341778
124* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.89685671
125BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89581353
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.89527688
127TP53_22573176_ChIP-Seq_HFKS_Human0.88486945
128RNF2_27304074_Chip-Seq_NSC_Mouse0.88084350
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86796003
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.84653431
131CBP_20019798_ChIP-Seq_JUKART_Human0.83956745
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83956745
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.83618048
134SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.82865398
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.82604293
136* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82504355
137SOX2_16153702_ChIP-ChIP_HESCs_Human0.81837175
138EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81432631
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81351021

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.38938115
2MP0004957_abnormal_blastocyst_morpholog4.33714299
3MP0010094_abnormal_chromosome_stability4.25508274
4MP0003111_abnormal_nucleus_morphology4.20616604
5MP0003077_abnormal_cell_cycle3.80340806
6MP0008058_abnormal_DNA_repair3.47762940
7MP0003123_paternal_imprinting3.41474524
8MP0008057_abnormal_DNA_replication3.38821443
9MP0008932_abnormal_embryonic_tissue2.96151526
10MP0008007_abnormal_cellular_replicative2.93497433
11MP0008877_abnormal_DNA_methylation2.92488459
12MP0001730_embryonic_growth_arrest2.45886909
13MP0000569_abnormal_digit_pigmentation2.12189232
14MP0003121_genomic_imprinting2.12031386
15MP0000350_abnormal_cell_proliferation2.08912062
16MP0003718_maternal_effect2.00686937
17MP0006292_abnormal_olfactory_placode1.82577713
18MP0002736_abnormal_nociception_after1.82248351
19MP0010030_abnormal_orbit_morphology1.78384744
20MP0003786_premature_aging1.78162613
21MP0001672_abnormal_embryogenesis/_devel1.77656684
22MP0005380_embryogenesis_phenotype1.77656684
23MP0003195_calcinosis1.75930166
24MP0001697_abnormal_embryo_size1.75448304
25MP0002085_abnormal_embryonic_tissue1.64863857
26MP0005408_hypopigmentation1.59393250
27MP0003890_abnormal_embryonic-extraembry1.59064711
28MP0002084_abnormal_developmental_patter1.59002295
29MP0004133_heterotaxia1.55901164
30MP0003806_abnormal_nucleotide_metabolis1.55429076
31MP0002080_prenatal_lethality1.54836658
32MP0002102_abnormal_ear_morphology1.54133173
33MP0003984_embryonic_growth_retardation1.53956576
34MP0001968_abnormal_touch/_nociception1.53739143
35MP0002088_abnormal_embryonic_growth/wei1.50310616
36MP0001986_abnormal_taste_sensitivity1.45607495
37MP0000372_irregular_coat_pigmentation1.44579410
38MP0005187_abnormal_penis_morphology1.44264675
39MP0000427_abnormal_hair_cycle1.44170004
40MP0002653_abnormal_ependyma_morphology1.43389142
41MP0010307_abnormal_tumor_latency1.41835190
42MP0002234_abnormal_pharynx_morphology1.38492479
43MP0004197_abnormal_fetal_growth/weight/1.37651681
44MP0001293_anophthalmia1.37536328
45MP0002938_white_spotting1.36609440
46MP0001529_abnormal_vocalization1.33827058
47MP0003315_abnormal_perineum_morphology1.29460310
48MP0002735_abnormal_chemical_nociception1.28820385
49MP0002210_abnormal_sex_determination1.27147563
50MP0006072_abnormal_retinal_apoptosis1.26329286
51MP0008789_abnormal_olfactory_epithelium1.25129376
52MP0003119_abnormal_digestive_system1.22979148
53MP0003937_abnormal_limbs/digits/tail_de1.22574766
54MP0003122_maternal_imprinting1.20830096
55MP0002086_abnormal_extraembryonic_tissu1.20259379
56MP0010352_gastrointestinal_tract_polyps1.17412904
57MP0003567_abnormal_fetal_cardiomyocyte1.17304655
58MP0002396_abnormal_hematopoietic_system1.15799722
59MP0000313_abnormal_cell_death1.15344002
60MP0001324_abnormal_eye_pigmentation1.11696767
61MP0001666_abnormal_nutrient_absorption1.09598493
62MP0001929_abnormal_gametogenesis1.09107153
63MP0000631_abnormal_neuroendocrine_gland1.08912092
64MP0001145_abnormal_male_reproductive1.06453802
65MP0003186_abnormal_redox_activity1.05714335
66MP0001919_abnormal_reproductive_system1.05710498
67MP0009379_abnormal_foot_pigmentation1.05535461
68MP0003011_delayed_dark_adaptation1.05307231
69MP0008995_early_reproductive_senescence1.03879323
70MP0002160_abnormal_reproductive_system1.03860757
71MP0000358_abnormal_cell_content/1.00614105
72MP0003941_abnormal_skin_development1.00075333
73MP0004142_abnormal_muscle_tone0.96196841
74MP0000428_abnormal_craniofacial_morphol0.95770081
75MP0008872_abnormal_physiological_respon0.95609087
76MP0002734_abnormal_mechanical_nocicepti0.95339177
77MP0000653_abnormal_sex_gland0.94927669
78MP0005084_abnormal_gallbladder_morpholo0.94552661
79MP0003221_abnormal_cardiomyocyte_apopto0.94409408
80MP0002638_abnormal_pupillary_reflex0.94202629
81MP0009046_muscle_twitch0.94048219
82MP0002697_abnormal_eye_size0.93571861
83MP0000647_abnormal_sebaceous_gland0.92806288
84MP0002751_abnormal_autonomic_nervous0.91200949
85MP0003868_abnormal_feces_composition0.89814687
86MP0003950_abnormal_plasma_membrane0.88472614
87MP0002019_abnormal_tumor_incidence0.87633500
88MP0009672_abnormal_birth_weight0.86586460
89MP0000537_abnormal_urethra_morphology0.85934726
90MP0002111_abnormal_tail_morphology0.85783116
91MP0000566_synostosis0.85501786
92MP0003880_abnormal_central_pattern0.85360586
93MP0002557_abnormal_social/conspecific_i0.84532013
94MP0000778_abnormal_nervous_system0.84451587
95MP0003787_abnormal_imprinting0.84343898
96MP0005499_abnormal_olfactory_system0.84331487
97MP0005394_taste/olfaction_phenotype0.84331487
98MP0006035_abnormal_mitochondrial_morpho0.83824337
99MP0008875_abnormal_xenobiotic_pharmacok0.83678698
100MP0009697_abnormal_copulation0.83657157
101MP0001286_abnormal_eye_development0.83165292
102MP0005384_cellular_phenotype0.82871463
103MP0005389_reproductive_system_phenotype0.82431851
104MP0004924_abnormal_behavior0.81744137
105MP0005386_behavior/neurological_phenoty0.81744137
106MP0005085_abnormal_gallbladder_physiolo0.81093448
107MP0005646_abnormal_pituitary_gland0.80567890
108MP0000049_abnormal_middle_ear0.80488655
109MP0003861_abnormal_nervous_system0.79976219
110MP0003755_abnormal_palate_morphology0.79676623
111MP0005195_abnormal_posterior_eye0.79503791
112MP0002184_abnormal_innervation0.78224304
113MP0009703_decreased_birth_body0.76666452
114MP0003938_abnormal_ear_development0.75839550
115MP0001485_abnormal_pinna_reflex0.75693132
116MP0003942_abnormal_urinary_system0.75166670
117MP0004233_abnormal_muscle_weight0.74225107
118MP0001905_abnormal_dopamine_level0.74197669
119MP0002277_abnormal_respiratory_mucosa0.73192263
120MP0008260_abnormal_autophagy0.73140081
121MP0003698_abnormal_male_reproductive0.73046829
122MP0005391_vision/eye_phenotype0.72596423
123MP0005076_abnormal_cell_differentiation0.72093127
124MP0002114_abnormal_axial_skeleton0.70294811
125MP0005253_abnormal_eye_physiology0.69920104
126MP0000490_abnormal_crypts_of0.68933294
127MP0009333_abnormal_splenocyte_physiolog0.68518646
128MP0001849_ear_inflammation0.68264191
129MP0005621_abnormal_cell_physiology0.67088091
130MP0002127_abnormal_cardiovascular_syste0.66329997
131MP0003136_yellow_coat_color0.65913428
132MP0004145_abnormal_muscle_electrophysio0.65316392
133MP0005367_renal/urinary_system_phenotyp0.64863943
134MP0000516_abnormal_urinary_system0.64863943
135MP0000750_abnormal_muscle_regeneration0.64464718
136MP0002161_abnormal_fertility/fecundity0.62534764
137MP0000432_abnormal_head_morphology0.61362370
138MP0005551_abnormal_eye_electrophysiolog0.60868928
139MP0002233_abnormal_nose_morphology0.59711578
140MP0001119_abnormal_female_reproductive0.59711101
141MP0001727_abnormal_embryo_implantation0.57927714

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.91478322
2Cerebral hypomyelination (HP:0006808)4.49080045
3Breast hypoplasia (HP:0003187)4.03139823
4Abnormality of the labia minora (HP:0012880)3.76894299
5Degeneration of anterior horn cells (HP:0002398)3.60565857
6Abnormality of the anterior horn cell (HP:0006802)3.60565857
7Patellar aplasia (HP:0006443)3.59655022
8Carpal bone hypoplasia (HP:0001498)3.59123441
9Aplasia/Hypoplasia of the patella (HP:0006498)3.39091290
10Ependymoma (HP:0002888)3.28802373
11Medulloblastoma (HP:0002885)3.23527196
12Increased hepatocellular lipid droplets (HP:0006565)3.11982041
13Acute necrotizing encephalopathy (HP:0006965)3.10805623
14Acute encephalopathy (HP:0006846)3.10636781
15Colon cancer (HP:0003003)3.02857614
16Impulsivity (HP:0100710)2.94946227
17Rough bone trabeculation (HP:0100670)2.84905704
18Supernumerary spleens (HP:0009799)2.84065303
19Lipid accumulation in hepatocytes (HP:0006561)2.83556085
20Abnormal mitochondria in muscle tissue (HP:0008316)2.80090879
21Absent radius (HP:0003974)2.76270060
22Oral leukoplakia (HP:0002745)2.70960998
23CNS hypomyelination (HP:0003429)2.67482988
24Meckel diverticulum (HP:0002245)2.65045443
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.63280351
26Progressive macrocephaly (HP:0004481)2.62907112
27Increased CSF lactate (HP:0002490)2.62746398
28Selective tooth agenesis (HP:0001592)2.61219232
29Abnormality of the ileum (HP:0001549)2.57504601
30Mitochondrial inheritance (HP:0001427)2.54762652
31Aplasia involving forearm bones (HP:0009822)2.54401479
32Absent forearm bone (HP:0003953)2.54401479
33Hyperglycinemia (HP:0002154)2.53923455
34Abnormality of alanine metabolism (HP:0010916)2.52266284
35Hyperalaninemia (HP:0003348)2.52266284
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52266284
37Abnormality of the preputium (HP:0100587)2.51574731
38Horseshoe kidney (HP:0000085)2.46488585
39Abnormality of glycolysis (HP:0004366)2.44449463
40Increased serum pyruvate (HP:0003542)2.44449463
41Facial cleft (HP:0002006)2.43675559
42Trismus (HP:0000211)2.43543736
43True hermaphroditism (HP:0010459)2.40047769
44Abnormal lung lobation (HP:0002101)2.39238367
45Stenosis of the external auditory canal (HP:0000402)2.38844818
46Congenital stationary night blindness (HP:0007642)2.35024882
47Premature ovarian failure (HP:0008209)2.32887500
48Rhabdomyosarcoma (HP:0002859)2.32233984
49Pendular nystagmus (HP:0012043)2.30105322
50Abnormality of chromosome stability (HP:0003220)2.28259038
51Astrocytoma (HP:0009592)2.27072569
52Abnormality of the astrocytes (HP:0100707)2.27072569
53Chromsome breakage (HP:0040012)2.25332883
54Renal cortical cysts (HP:0000803)2.24386202
55Hypoplastic pelvis (HP:0008839)2.22667171
56Glioma (HP:0009733)2.21303863
57Abnormality of the carotid arteries (HP:0005344)2.20734066
58Abnormality of midbrain morphology (HP:0002418)2.20667884
59Molar tooth sign on MRI (HP:0002419)2.20667884
60Premature graying of hair (HP:0002216)2.19782443
61Atresia of the external auditory canal (HP:0000413)2.19177938
62Hyperglycinuria (HP:0003108)2.19009043
63Congenital, generalized hypertrichosis (HP:0004540)2.17497405
64Neoplasm of the pancreas (HP:0002894)2.16455831
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16187254
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.15428939
67Abnormality of glycine metabolism (HP:0010895)2.15384638
68Abnormality of serine family amino acid metabolism (HP:0010894)2.15384638
69Cerebral edema (HP:0002181)2.14697242
70Renal Fanconi syndrome (HP:0001994)2.14239213
71Absent thumb (HP:0009777)2.13583154
72Reticulocytopenia (HP:0001896)2.13493099
73Duodenal stenosis (HP:0100867)2.13457842
74Small intestinal stenosis (HP:0012848)2.13457842
75Facial hemangioma (HP:0000329)2.13081539
76Atrophy/Degeneration involving motor neurons (HP:0007373)2.12147766
77Hypoplasia of the capital femoral epiphysis (HP:0003090)2.11398259
78Spinal muscular atrophy (HP:0007269)2.10979603
79Increased serum lactate (HP:0002151)2.10030011
80Postnatal microcephaly (HP:0005484)2.09183757
81Abnormal number of incisors (HP:0011064)2.08067381
82Sloping forehead (HP:0000340)2.07837055
83Methylmalonic acidemia (HP:0002912)2.07602125
84Secondary amenorrhea (HP:0000869)2.07214911
85Hypothermia (HP:0002045)2.06091490
86Abnormality of serum amino acid levels (HP:0003112)2.04696409
87Abnormal trabecular bone morphology (HP:0100671)2.04614639
88Squamous cell carcinoma (HP:0002860)2.03876532
89Abnormality of cells of the erythroid lineage (HP:0012130)2.02587816
90Volvulus (HP:0002580)2.00681224
91Hepatic necrosis (HP:0002605)1.96723785
92Irregular epiphyses (HP:0010582)1.96238983
93Aplastic anemia (HP:0001915)1.95877470
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.95075430
95Hepatocellular necrosis (HP:0001404)1.95071283
96Unsteady gait (HP:0002317)1.94565379
97Concave nail (HP:0001598)1.93831424
98Shoulder girdle muscle weakness (HP:0003547)1.93484212
99Delusions (HP:0000746)1.91842960
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.91822745
101Embryonal renal neoplasm (HP:0011794)1.91625570
102Cleft eyelid (HP:0000625)1.91398317
103Cellular immunodeficiency (HP:0005374)1.91139748
104Gonadotropin excess (HP:0000837)1.89933337
105Neoplasm of the oral cavity (HP:0100649)1.89909644
106Pancreatic fibrosis (HP:0100732)1.89881538
107Nephroblastoma (Wilms tumor) (HP:0002667)1.89642949
108Hypophosphatemic rickets (HP:0004912)1.87803140
109Aplasia/hypoplasia of the humerus (HP:0006507)1.87725316
110Bone marrow hypocellularity (HP:0005528)1.87368140
111Nephronophthisis (HP:0000090)1.85821375
112Abnormality of the pons (HP:0007361)1.85498385
113Medial flaring of the eyebrow (HP:0010747)1.85462431
114Agnosia (HP:0010524)1.85123283
115Neoplasm of striated muscle (HP:0009728)1.85019470
116Septo-optic dysplasia (HP:0100842)1.84413247
117Hypoplasia of the pons (HP:0012110)1.84383963
118Glossoptosis (HP:0000162)1.83699300
119Myelodysplasia (HP:0002863)1.83219153
120Abnormal number of erythroid precursors (HP:0012131)1.80263947
121Proximal placement of thumb (HP:0009623)1.79734887
122Sparse lateral eyebrow (HP:0005338)1.79613053
123Pancreatic cysts (HP:0001737)1.79051032
124Breast aplasia (HP:0100783)1.79044710
125Anophthalmia (HP:0000528)1.78996746
1263-Methylglutaconic aciduria (HP:0003535)1.77876831
127Macrocytic anemia (HP:0001972)1.77368207
128Deviation of the thumb (HP:0009603)1.76478692
129Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76427105
130Lethargy (HP:0001254)1.75726354
131Optic disc pallor (HP:0000543)1.75301600
132Abnormality of the umbilical cord (HP:0010881)1.75009655
133Sclerocornea (HP:0000647)1.74887647
134Cortical dysplasia (HP:0002539)1.74338015
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.74049317
136Absent epiphyses (HP:0010577)1.74049317
137Ectopic kidney (HP:0000086)1.73737799
138Triphalangeal thumb (HP:0001199)1.73526594
139Oligodactyly (HP:0012165)1.73490406
140Lactic acidosis (HP:0003128)1.72606286
141Abdominal situs inversus (HP:0003363)1.72550474
142Abnormality of abdominal situs (HP:0011620)1.72550474
143Hyperventilation (HP:0002883)1.72280698
144Severe visual impairment (HP:0001141)1.72108213
145Scrotal hypoplasia (HP:0000046)1.71820736
146Multiple enchondromatosis (HP:0005701)1.71113252
147Abnormality of the duodenum (HP:0002246)1.70988794
148Pelvic girdle muscle weakness (HP:0003749)1.70673352
149Type I transferrin isoform profile (HP:0003642)1.70468876
150Abnormality of methionine metabolism (HP:0010901)1.69877029
151Prolonged partial thromboplastin time (HP:0003645)1.65463386
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.65125836
153Anencephaly (HP:0002323)1.64877499
154Hypobetalipoproteinemia (HP:0003563)1.64851904
155Glycosuria (HP:0003076)1.63763790
156Abnormality of urine glucose concentration (HP:0011016)1.63763790
157Abnormality of the renal cortex (HP:0011035)1.62106212
158Genital tract atresia (HP:0001827)1.62094380
159Small hand (HP:0200055)1.61510060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.14857592
2WEE14.26159695
3EIF2AK13.80224103
4CASK3.43441424
5CDC73.23836199
6TSSK63.14756736
7SRPK13.01145280
8PLK42.74002203
9PNCK2.59046004
10BRSK22.40848907
11PLK32.30273760
12TTK2.25717252
13EIF2AK32.24932845
14STK162.24258010
15TRIM282.18943472
16NEK22.11566675
17MKNK12.09874025
18VRK22.08467789
19PLK12.07972869
20NEK12.03184945
21TNIK1.86279480
22VRK11.84751624
23MKNK21.76863236
24EPHA21.73783519
25PASK1.67347653
26TESK21.65105442
27INSRR1.61798057
28TAF11.60536206
29ACVR1B1.60519722
30CHEK21.49927277
31AURKA1.46995703
32AURKB1.46959932
33CDK71.44639055
34STK38L1.44604017
35CCNB11.42170000
36MAP3K41.41195543
37BRSK11.41108324
38RPS6KB21.37757779
39ATR1.36796191
40WNK41.35422242
41FRK1.34800027
42AKT31.32998303
43MAP4K21.32636267
44CDK121.30836706
45BRAF1.28499825
46ZAK1.28310951
47STK391.26767836
48CHEK11.18814965
49PIK3CA1.14485978
50BCR1.11607643
51PIM21.11044844
52DYRK31.10167983
53MAP2K71.07174849
54TLK10.99542364
55ADRBK20.95115327
56NME20.93442234
57GRK10.91714949
58CDK80.88468350
59DYRK20.87143333
60CSNK2A20.84696252
61CDK20.84630394
62SCYL20.84386243
63MAPKAPK30.84069411
64RPS6KA40.82734902
65NME10.82696313
66MAPK130.82641873
67TESK10.82535107
68ATM0.82506546
69BRD40.79339452
70LIMK10.78431379
71MAP3K80.76207010
72PBK0.75972587
73ARAF0.75283721
74BCKDK0.75216916
75MAP3K120.74834386
76PAK10.74014617
77CDK10.73179322
78TGFBR10.71893999
79PRKCG0.70989689
80MARK10.69813011
81CSNK2A10.69608486
82ALK0.68600058
83CDK40.68488327
84PAK40.67184693
85PDK40.67170561
86PDK30.67170561
87EIF2AK20.66375814
88CSNK1E0.66248572
89CSNK1G30.65553274
90ERBB30.64882944
91LATS20.62745788
92OXSR10.61432976
93RPS6KA50.61331230
94PRKCI0.59491906
95MUSK0.57616724
96SIK30.57262588
97DAPK10.56250677
98MELK0.55559789
99ERBB40.54951953
100MAPKAPK50.53072242
101MST40.53035243
102PAK30.51471462
103PLK20.46922394
104CSNK1G10.46682009
105PRKCE0.45042339
106PIM10.41924668
107CDK30.40759766
108STK40.37571078
109STK100.36399817
110NEK60.35861072
111NTRK20.35754646
112PRKDC0.34662169
113MINK10.34178498
114CSNK1G20.33527374
115RAF10.31755660
116MTOR0.31649161
117CDK11A0.30378029
118CDK180.30101639
119CDK140.29924525
120PRKCH0.28747550
121RPS6KB10.28725632
122WNK30.28702249
123CSNK1A1L0.28632619
124MARK30.27965458
125AKT20.27115025
126NUAK10.26702108
127STK30.26069783
128PRKACB0.25661703
129MAPK140.25381386
130CDK150.25236726
131TYRO30.24755902
132GSK3B0.24327310
133PDK20.23182519
134CSNK1A10.22450786
135BMPR1B0.21763768
136ILK0.20789468
137FGFR10.20411776

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.29025338
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.12757243
3RNA polymerase_Homo sapiens_hsa030203.95476311
4DNA replication_Homo sapiens_hsa030303.92415843
5Mismatch repair_Homo sapiens_hsa034303.74128164
6RNA transport_Homo sapiens_hsa030133.55266364
7Spliceosome_Homo sapiens_hsa030403.54089800
8Ribosome_Homo sapiens_hsa030102.94365991
9Nucleotide excision repair_Homo sapiens_hsa034202.84218074
10Cell cycle_Homo sapiens_hsa041102.70203665
11Homologous recombination_Homo sapiens_hsa034402.66954123
12Base excision repair_Homo sapiens_hsa034102.57073075
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55554667
14Basal transcription factors_Homo sapiens_hsa030222.47534516
15Pyrimidine metabolism_Homo sapiens_hsa002402.39985729
16One carbon pool by folate_Homo sapiens_hsa006702.15397332
17mRNA surveillance pathway_Homo sapiens_hsa030152.05983979
18Fanconi anemia pathway_Homo sapiens_hsa034601.99282562
19RNA degradation_Homo sapiens_hsa030181.99131156
20Non-homologous end-joining_Homo sapiens_hsa034501.88753830
21Propanoate metabolism_Homo sapiens_hsa006401.72937296
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69157803
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61537545
24p53 signaling pathway_Homo sapiens_hsa041151.54159740
25Purine metabolism_Homo sapiens_hsa002301.50375799
26Protein export_Homo sapiens_hsa030601.49603168
27Vitamin B6 metabolism_Homo sapiens_hsa007501.38631827
28Oocyte meiosis_Homo sapiens_hsa041141.37433446
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33957039
30Butanoate metabolism_Homo sapiens_hsa006501.32888620
31Epstein-Barr virus infection_Homo sapiens_hsa051691.27813984
32Phototransduction_Homo sapiens_hsa047441.26667227
33Fatty acid elongation_Homo sapiens_hsa000621.24535901
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23894328
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.23549093
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21127246
37Huntingtons disease_Homo sapiens_hsa050161.14581177
38Parkinsons disease_Homo sapiens_hsa050121.04830177
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.02403238
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.01822577
41Oxidative phosphorylation_Homo sapiens_hsa001901.01353975
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00551382
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97698004
44Fatty acid metabolism_Homo sapiens_hsa012120.92572623
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92147502
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91902519
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83645292
48Biosynthesis of amino acids_Homo sapiens_hsa012300.83328309
49Peroxisome_Homo sapiens_hsa041460.83231288
50Tryptophan metabolism_Homo sapiens_hsa003800.78336706
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77984126
52Systemic lupus erythematosus_Homo sapiens_hsa053220.77771711
53Pentose phosphate pathway_Homo sapiens_hsa000300.76582447
54Viral carcinogenesis_Homo sapiens_hsa052030.75327630
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75010426
56Nicotine addiction_Homo sapiens_hsa050330.74742968
57Folate biosynthesis_Homo sapiens_hsa007900.73979202
58Nitrogen metabolism_Homo sapiens_hsa009100.73862520
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73003067
60Linoleic acid metabolism_Homo sapiens_hsa005910.71079778
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69418253
62Regulation of autophagy_Homo sapiens_hsa041400.66999361
63Fat digestion and absorption_Homo sapiens_hsa049750.66903339
64Fructose and mannose metabolism_Homo sapiens_hsa000510.63493764
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63444668
66Fatty acid degradation_Homo sapiens_hsa000710.62982998
67Caffeine metabolism_Homo sapiens_hsa002320.59076218
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57831945
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57620375
70Thyroid cancer_Homo sapiens_hsa052160.57445653
71Chemical carcinogenesis_Homo sapiens_hsa052040.57393573
72Hedgehog signaling pathway_Homo sapiens_hsa043400.57218476
73Hippo signaling pathway_Homo sapiens_hsa043900.55775890
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55490832
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.53218744
76Alcoholism_Homo sapiens_hsa050340.52880022
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52263233
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50901611
79Antigen processing and presentation_Homo sapiens_hsa046120.50432963
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49703497
81Vitamin digestion and absorption_Homo sapiens_hsa049770.49225955
82Basal cell carcinoma_Homo sapiens_hsa052170.49221330
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49085714
84Retinol metabolism_Homo sapiens_hsa008300.49068191
85Ether lipid metabolism_Homo sapiens_hsa005650.48623655
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46311773
87Primary bile acid biosynthesis_Homo sapiens_hsa001200.45743498
88HTLV-I infection_Homo sapiens_hsa051660.45734848
89TGF-beta signaling pathway_Homo sapiens_hsa043500.45099680
90Alzheimers disease_Homo sapiens_hsa050100.42022468
91MicroRNAs in cancer_Homo sapiens_hsa052060.40972696
92N-Glycan biosynthesis_Homo sapiens_hsa005100.40382503
93beta-Alanine metabolism_Homo sapiens_hsa004100.39609007
94Carbon metabolism_Homo sapiens_hsa012000.39232890
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38769828
96Taste transduction_Homo sapiens_hsa047420.38750189
97Herpes simplex infection_Homo sapiens_hsa051680.38076024
98Fatty acid biosynthesis_Homo sapiens_hsa000610.37157601
99Sulfur metabolism_Homo sapiens_hsa009200.37129090
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36984681
101Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35139380
102Starch and sucrose metabolism_Homo sapiens_hsa005000.34741574
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32252708
104Metabolic pathways_Homo sapiens_hsa011000.31372979
105Vibrio cholerae infection_Homo sapiens_hsa051100.31115702
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29948578
107Glutathione metabolism_Homo sapiens_hsa004800.28591812
108Selenocompound metabolism_Homo sapiens_hsa004500.27714042
109Sulfur relay system_Homo sapiens_hsa041220.26806333
110Tyrosine metabolism_Homo sapiens_hsa003500.26061770
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25945472
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.24095930
113Colorectal cancer_Homo sapiens_hsa052100.22947424
114Galactose metabolism_Homo sapiens_hsa000520.22718095
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.22663525
116Wnt signaling pathway_Homo sapiens_hsa043100.22106644
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21512009
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20544443
119Pathways in cancer_Homo sapiens_hsa052000.18259586
120Bladder cancer_Homo sapiens_hsa052190.17832270
121Cardiac muscle contraction_Homo sapiens_hsa042600.17760817
122Tight junction_Homo sapiens_hsa045300.17368915
123Legionellosis_Homo sapiens_hsa051340.16663460
124mTOR signaling pathway_Homo sapiens_hsa041500.16092817
125Collecting duct acid secretion_Homo sapiens_hsa049660.14543208
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14470330
127Small cell lung cancer_Homo sapiens_hsa052220.13785066
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.12598688
129Arachidonic acid metabolism_Homo sapiens_hsa005900.12524860
130Melanoma_Homo sapiens_hsa052180.11162771
131HIF-1 signaling pathway_Homo sapiens_hsa040660.11041477
132Prostate cancer_Homo sapiens_hsa052150.10451248
133Arginine and proline metabolism_Homo sapiens_hsa003300.09839368
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.07979065
135Apoptosis_Homo sapiens_hsa042100.04548771
136Circadian rhythm_Homo sapiens_hsa047100.04389012
137Pyruvate metabolism_Homo sapiens_hsa006200.03227016
138Notch signaling pathway_Homo sapiens_hsa043300.02700800
139Steroid biosynthesis_Homo sapiens_hsa001000.02271558
140Shigellosis_Homo sapiens_hsa051310.02086008
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.01885980

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