LENG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.28048686
2ribosomal small subunit biogenesis (GO:0042274)7.20557943
3translational termination (GO:0006415)6.96953211
4maturation of SSU-rRNA (GO:0030490)6.21478650
5ribosomal large subunit biogenesis (GO:0042273)5.97764990
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.96356938
7translational elongation (GO:0006414)5.85780627
8protein targeting to ER (GO:0045047)5.85266972
9cotranslational protein targeting to membrane (GO:0006613)5.83618399
10ribosomal small subunit assembly (GO:0000028)5.75396718
11DNA deamination (GO:0045006)5.70100197
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.57337634
13protein localization to endoplasmic reticulum (GO:0070972)5.55261849
14viral life cycle (GO:0019058)5.43829334
15cellular protein complex disassembly (GO:0043624)5.36333503
16translational initiation (GO:0006413)5.25508599
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.14129533
18protein complex disassembly (GO:0043241)4.61591988
19ribonucleoprotein complex biogenesis (GO:0022613)4.40097976
20macromolecular complex disassembly (GO:0032984)4.36072403
21translation (GO:0006412)4.26429553
22termination of RNA polymerase III transcription (GO:0006386)4.12697703
23transcription elongation from RNA polymerase III promoter (GO:0006385)4.12697703
24DNA replication checkpoint (GO:0000076)3.99611599
25protein targeting to membrane (GO:0006612)3.95030930
26regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.77682886
27negative regulation of cell killing (GO:0031342)3.65605811
28negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65605811
29nuclear-transcribed mRNA catabolic process (GO:0000956)3.64114762
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.63240552
31cellular component biogenesis (GO:0044085)3.62141658
32spliceosomal complex assembly (GO:0000245)3.59065103
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.55893682
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.54518219
35rRNA processing (GO:0006364)3.50464751
36mRNA catabolic process (GO:0006402)3.46507411
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45437170
38deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.44477228
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.43957585
40chaperone-mediated protein transport (GO:0072321)3.43181192
41GMP metabolic process (GO:0046037)3.40207873
42base-excision repair, AP site formation (GO:0006285)3.39376072
43rRNA metabolic process (GO:0016072)3.38723370
44pseudouridine synthesis (GO:0001522)3.36669839
45spliceosomal snRNP assembly (GO:0000387)3.35358880
46ATP synthesis coupled proton transport (GO:0015986)3.34662756
47energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34662756
48mature B cell differentiation (GO:0002335)3.28673014
49ncRNA 3-end processing (GO:0043628)3.25758116
50response to interferon-beta (GO:0035456)3.22058015
51RNA catabolic process (GO:0006401)3.19923831
52respiratory electron transport chain (GO:0022904)3.18813621
53deoxyribonucleotide catabolic process (GO:0009264)3.16396310
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.14800234
55amino sugar catabolic process (GO:0046348)3.14730641
56amino acid salvage (GO:0043102)3.14350548
57L-methionine salvage (GO:0071267)3.14350548
58L-methionine biosynthetic process (GO:0071265)3.14350548
59proteasome assembly (GO:0043248)3.12650239
60electron transport chain (GO:0022900)3.10216913
61mature B cell differentiation involved in immune response (GO:0002313)3.06809015
62Arp2/3 complex-mediated actin nucleation (GO:0034314)3.06635644
63pyrimidine nucleotide catabolic process (GO:0006244)3.04823470
64cytidine metabolic process (GO:0046087)3.03098435
65cytidine catabolic process (GO:0006216)3.03098435
66cytidine deamination (GO:0009972)3.03098435
67DNA damage response, detection of DNA damage (GO:0042769)3.01173066
68protein complex biogenesis (GO:0070271)3.00974916
69protein targeting to mitochondrion (GO:0006626)3.00834774
70purine deoxyribonucleotide catabolic process (GO:0009155)3.00267290
71rRNA modification (GO:0000154)2.98648994
72deoxyribose phosphate catabolic process (GO:0046386)2.98255394
73purine nucleotide salvage (GO:0032261)2.95820289
74heme biosynthetic process (GO:0006783)2.95759606
75mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88624865
76mitochondrial respiratory chain complex I assembly (GO:0032981)2.88624865
77NADH dehydrogenase complex assembly (GO:0010257)2.88624865
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88197552
79mitochondrial calcium ion transport (GO:0006851)2.85768434
80protein targeting (GO:0006605)2.85682962
81mitochondrial respiratory chain complex assembly (GO:0033108)2.83009731
82establishment of protein localization to mitochondrion (GO:0072655)2.81280802
83ribosome biogenesis (GO:0042254)2.81223961
84glucosamine-containing compound catabolic process (GO:1901072)2.81128747
85GDP-mannose metabolic process (GO:0019673)2.79438325
86telomere maintenance via semi-conservative replication (GO:0032201)2.78190713
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.77875125
88positive regulation of gamma-delta T cell activation (GO:0046645)2.74291359
89negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72658714
90establishment of protein localization to membrane (GO:0090150)2.70810622
91establishment of protein localization to organelle (GO:0072594)2.70390296
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68993318
93protein deneddylation (GO:0000338)2.68459900
94tumor necrosis factor-mediated signaling pathway (GO:0033209)2.66559962
95mitotic metaphase plate congression (GO:0007080)2.66524674
96regulation of mitochondrial translation (GO:0070129)2.65926467
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.65003861
98GTP biosynthetic process (GO:0006183)2.65001802
99folic acid metabolic process (GO:0046655)2.64876491
100cellular response to interleukin-15 (GO:0071350)2.63391903
1017-methylguanosine mRNA capping (GO:0006370)2.61512510
102immunoglobulin mediated immune response (GO:0016064)2.61429900
103peptidyl-histidine modification (GO:0018202)2.61066666
104antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.59993433
105guanosine-containing compound biosynthetic process (GO:1901070)2.59630926
106negative regulation of ligase activity (GO:0051352)2.59364804
107negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59364804
108DNA strand elongation involved in DNA replication (GO:0006271)2.58823468
109positive regulation of defense response to virus by host (GO:0002230)2.58714877
110DNA replication initiation (GO:0006270)2.57779438
111pyrimidine ribonucleoside catabolic process (GO:0046133)2.56537273
112positive regulation of viral transcription (GO:0050434)2.55545047
113purine-containing compound salvage (GO:0043101)2.54084355
114tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.52995142
115RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.52995142
116RNA capping (GO:0036260)2.52666613
1177-methylguanosine RNA capping (GO:0009452)2.52666613
118transcription elongation from RNA polymerase II promoter (GO:0006368)2.52269052
119protein localization to mitochondrion (GO:0070585)2.52088799
120cellular response to interferon-beta (GO:0035458)2.51816730
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51809247
122sarcomere organization (GO:0045214)2.51368245
123negative T cell selection (GO:0043383)2.50169603
124transcription-coupled nucleotide-excision repair (GO:0006283)2.49357821
125actin nucleation (GO:0045010)2.49272509
126blastocyst development (GO:0001824)2.48789098
127UTP biosynthetic process (GO:0006228)2.47889891
128ncRNA processing (GO:0034470)2.47633746
129heme metabolic process (GO:0042168)2.47275950
130negative regulation of viral genome replication (GO:0045071)2.46762925
131regulation of natural killer cell mediated immunity (GO:0002715)2.46255187
132regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.46255187
133negative regulation of innate immune response (GO:0045824)2.45237722
134rRNA methylation (GO:0031167)2.44632989
135protein neddylation (GO:0045116)2.44632737
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.44521999
137iron-sulfur cluster assembly (GO:0016226)2.44090037
138metallo-sulfur cluster assembly (GO:0031163)2.44090037
139protoporphyrinogen IX metabolic process (GO:0046501)2.43077870
140leukocyte aggregation (GO:0070486)2.42955766
141DNA strand elongation (GO:0022616)2.42791276
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.42657104
143interferon-gamma production (GO:0032609)2.42534934
144regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.42321247
145transcription from RNA polymerase III promoter (GO:0006383)2.41868492
146glycine metabolic process (GO:0006544)2.41415705
147transcription from RNA polymerase I promoter (GO:0006360)2.40937469
148negative regulation of interleukin-12 production (GO:0032695)2.40901569
149negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.40193831
150negative regulation of DNA-templated transcription, elongation (GO:0032785)2.40193831
151DNA-templated transcription, elongation (GO:0006354)2.38922451
152telomere maintenance via recombination (GO:0000722)2.38224199
153protoporphyrinogen IX biosynthetic process (GO:0006782)2.37175232
154pteridine-containing compound biosynthetic process (GO:0042559)2.36814569

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.00107039
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.46769796
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36621908
4E2F7_22180533_ChIP-Seq_HELA_Human3.29625020
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26855717
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.24729629
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.20196910
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.16663721
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06595364
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.05326055
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.95024199
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.77261573
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66776620
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52783548
15XRN2_22483619_ChIP-Seq_HELA_Human2.47898114
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.43070659
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.41285537
18* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.22525791
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20759048
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.12345975
21CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.11207120
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05490681
23* DCP1A_22483619_ChIP-Seq_HELA_Human2.03088392
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99865912
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99457735
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.98603610
27PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.98541690
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.97121708
29VDR_23849224_ChIP-Seq_CD4+_Human1.95300570
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84844733
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84778362
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83093776
33TTF2_22483619_ChIP-Seq_HELA_Human1.76634955
34IRF8_21731497_ChIP-ChIP_J774_Mouse1.76474204
35* GABP_19822575_ChIP-Seq_HepG2_Human1.72944324
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71981278
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71856689
38TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71015820
39FOXP3_21729870_ChIP-Seq_TREG_Human1.70110910
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.69882854
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67859997
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.66302407
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.63522167
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.60249443
45BCL6_27268052_Chip-Seq_Bcells_Human1.59727971
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53296423
47SPI1_23547873_ChIP-Seq_NB4_Human1.53185230
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50628213
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48926212
50THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47945762
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.46695063
52* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.45314893
53* UTX_26944678_Chip-Seq_JUKART_Human1.44787309
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42946725
55VDR_21846776_ChIP-Seq_THP-1_Human1.42254253
56CIITA_25753668_ChIP-Seq_RAJI_Human1.42025228
57ELK1_22589737_ChIP-Seq_MCF10A_Human1.40195982
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37317861
59STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36485785
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.35874440
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.32243696
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.32112232
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31561643
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.30027206
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.29590575
66* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29488461
67VDR_24763502_ChIP-Seq_THP-1_Human1.29302615
68ZNF263_19887448_ChIP-Seq_K562_Human1.27535940
69MYB_26560356_Chip-Seq_TH2_Human1.27243565
70BCOR_27268052_Chip-Seq_Bcells_Human1.26402083
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26316144
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25723392
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21490755
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21352892
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21023847
76HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20974335
77ELK1_19687146_ChIP-ChIP_HELA_Human1.20335456
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19395608
79* P68_20966046_ChIP-Seq_HELA_Human1.19092711
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18998110
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.18660392
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16336826
83SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.16103044
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16006291
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15687612
86E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.15405088
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15146157
88CTCF_26484167_Chip-Seq_Bcells_Mouse1.14939540
89TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13429448
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13373455
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13251657
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11220775
93* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11116662
94KDM5A_27292631_Chip-Seq_BREAST_Human1.10956031
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10880968
96LXR_22292898_ChIP-Seq_THP-1_Human1.07947164
97AR_21909140_ChIP-Seq_LNCAP_Human1.07850274
98* MAF_26560356_Chip-Seq_TH2_Human1.07498964
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07402419
100ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07245016
101STAT1_20625510_ChIP-Seq_HELA_Human1.07068351
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06771105
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06501771
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06046296
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05977126
106* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05947518
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05612010
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04616410
109RUNX1_22412390_ChIP-Seq_EML_Mouse1.03156638
110TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03073326
111SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02813961
112CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01774115
113GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01643831
114FOXP1_21924763_ChIP-Seq_HESCs_Human1.00181691
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99909445
116MYB_26560356_Chip-Seq_TH1_Human0.99194015
117E2F1_20622854_ChIP-Seq_HELA_Human0.99150236
118TFEB_21752829_ChIP-Seq_HELA_Human0.98214390
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97718261
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97543061
121MYC_22102868_ChIP-Seq_BL_Human0.97216028
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95367373
123RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92058579
124SOX2_18692474_ChIP-Seq_MEFs_Mouse0.90728521
125MYC_18940864_ChIP-ChIP_HL60_Human0.90197378
126ELK3_25401928_ChIP-Seq_HUVEC_Human0.90079839
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89433375
128MAF_26560356_Chip-Seq_TH1_Human0.89310874
129* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89218110
130TET1_21451524_ChIP-Seq_MESCs_Mouse0.89122253
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88948166
132TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88403085
133ATF3_27146783_Chip-Seq_COLON_Human0.88378826
134E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87450152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.70844651
2MP0003011_delayed_dark_adaptation3.38861484
3MP0003693_abnormal_embryo_hatching3.30551434
4MP0009379_abnormal_foot_pigmentation3.24793704
5MP0003436_decreased_susceptibility_to3.20080758
6MP0002148_abnormal_hypersensitivity_rea2.86309578
7MP0001835_abnormal_antigen_presentation2.85769372
8MP0005000_abnormal_immune_tolerance2.78626943
9MP0009785_altered_susceptibility_to2.67646772
10MP0001800_abnormal_humoral_immune2.45885612
11MP0002723_abnormal_immune_serum2.44904889
12MP0005025_abnormal_response_to2.37744643
13MP0001790_abnormal_immune_system2.32872991
14MP0005387_immune_system_phenotype2.32872991
15MP0002420_abnormal_adaptive_immunity2.32136910
16MP0004381_abnormal_hair_follicle2.30662080
17MP0001819_abnormal_immune_cell2.29039413
18MP0000750_abnormal_muscle_regeneration2.28046671
19MP0002452_abnormal_antigen_presenting2.25987860
20MP0002419_abnormal_innate_immunity2.23175377
21MP0009840_abnormal_foam_cell2.22671905
22MP0009333_abnormal_splenocyte_physiolog2.20811472
23MP0002653_abnormal_ependyma_morphology2.18667038
24MP0002132_abnormal_respiratory_system2.09321498
25MP0009764_decreased_sensitivity_to2.02515382
26MP0006082_CNS_inflammation1.98017752
27MP0002277_abnormal_respiratory_mucosa1.94323980
28MP0002398_abnormal_bone_marrow1.91532422
29MP0004957_abnormal_blastocyst_morpholog1.89456040
30MP0000716_abnormal_immune_system1.88600384
31MP0002837_dystrophic_cardiac_calcinosis1.85143471
32MP0005330_cardiomyopathy1.83670893
33MP0003077_abnormal_cell_cycle1.80468201
34MP0003111_abnormal_nucleus_morphology1.80432652
35MP0001533_abnormal_skeleton_physiology1.80305448
36MP0002405_respiratory_system_inflammati1.76871517
37MP0003646_muscle_fatigue1.73121137
38MP0004084_abnormal_cardiac_muscle1.71602278
39MP0003806_abnormal_nucleotide_metabolis1.70092258
40MP0003136_yellow_coat_color1.68234514
41MP0000749_muscle_degeneration1.67856006
42MP0001845_abnormal_inflammatory_respons1.64817767
43MP0003718_maternal_effect1.62660770
44MP0003828_pulmonary_edema1.57513143
45MP0008932_abnormal_embryonic_tissue1.56455924
46MP0008260_abnormal_autophagy1.53483934
47MP0005464_abnormal_platelet_physiology1.53421425
48MP0000465_gastrointestinal_hemorrhage1.50358885
49MP0006036_abnormal_mitochondrial_physio1.49720048
50MP0005058_abnormal_lysosome_morphology1.48173840
51MP0008469_abnormal_protein_level1.47600388
52MP0008007_abnormal_cellular_replicative1.47401187
53MP0004147_increased_porphyrin_level1.46611156
54MP0003303_peritoneal_inflammation1.44203507
55MP0005083_abnormal_biliary_tract1.43946927
56MP0000343_altered_response_to1.39414830
57MP0003878_abnormal_ear_physiology1.31674287
58MP0005377_hearing/vestibular/ear_phenot1.31674287
59MP0004947_skin_inflammation1.30606209
60MP0003567_abnormal_fetal_cardiomyocyte1.28627181
61MP0003724_increased_susceptibility_to1.28451556
62MP0004215_abnormal_myocardial_fiber1.28067899
63MP0005451_abnormal_body_composition1.26804514
64MP0003137_abnormal_impulse_conducting1.23050088
65MP0010094_abnormal_chromosome_stability1.23011213
66MP0004510_myositis1.21528957
67MP0008058_abnormal_DNA_repair1.20830992
68MP0002102_abnormal_ear_morphology1.17468246
69MP0010630_abnormal_cardiac_muscle1.16261256
70MP0008995_early_reproductive_senescence1.16060999
71MP0010155_abnormal_intestine_physiology1.15897380
72MP0004036_abnormal_muscle_relaxation1.13007057
73MP0003221_abnormal_cardiomyocyte_apopto1.09096019
74MP0003186_abnormal_redox_activity1.08368881
75MP0009763_increased_sensitivity_to1.08239841
76MP0009278_abnormal_bone_marrow1.07758700
77MP0003315_abnormal_perineum_morphology1.07433551
78MP0005645_abnormal_hypothalamus_physiol1.05500695
79MP0002933_joint_inflammation1.05029627
80MP0003075_altered_response_to1.04755211
81MP0000490_abnormal_crypts_of1.03836251
82MP0001542_abnormal_bone_strength1.03399465
83MP0002396_abnormal_hematopoietic_system1.03006472
84MP0005332_abnormal_amino_acid0.98730966
85MP0001663_abnormal_digestive_system0.97732416
86MP0004087_abnormal_muscle_fiber0.97658265
87MP0000566_synostosis0.96330179
88MP0006138_congestive_heart_failure0.94547836
89MP0000751_myopathy0.94224958
90MP0000613_abnormal_salivary_gland0.94153101
91MP0005409_darkened_coat_color0.93240226
92MP0001853_heart_inflammation0.92817088
93MP0001544_abnormal_cardiovascular_syste0.92538043
94MP0005385_cardiovascular_system_phenoty0.92538043
95MP0003191_abnormal_cellular_cholesterol0.92353222
96MP0003786_premature_aging0.91245240
97MP0002106_abnormal_muscle_physiology0.90005657
98MP0001764_abnormal_homeostasis0.89759636
99MP0000372_irregular_coat_pigmentation0.89668024
100MP0009765_abnormal_xenobiotic_induced0.89489037
101MP0003950_abnormal_plasma_membrane0.89398374
102MP0005257_abnormal_intraocular_pressure0.89073006
103MP0005397_hematopoietic_system_phenotyp0.88487255
104MP0001545_abnormal_hematopoietic_system0.88487255
105MP0006035_abnormal_mitochondrial_morpho0.87480381
106MP0001730_embryonic_growth_arrest0.87399620
107MP0003763_abnormal_thymus_physiology0.86686538
108MP0003638_abnormal_response/metabolism_0.86398159
109MP0004185_abnormal_adipocyte_glucose0.84432069
110MP0009643_abnormal_urine_homeostasis0.84143109
111MP0003866_abnormal_defecation0.82858212
112MP0000350_abnormal_cell_proliferation0.82779672
113MP0004145_abnormal_muscle_electrophysio0.82307202
114MP0000747_muscle_weakness0.81996972
115MP0001919_abnormal_reproductive_system0.81954335
116MP0003656_abnormal_erythrocyte_physiolo0.81646038
117MP0005636_abnormal_mineral_homeostasis0.81604231
118MP0000703_abnormal_thymus_morphology0.81198894
119MP0000313_abnormal_cell_death0.80816530
120MP0001243_abnormal_dermal_layer0.80582829
121MP0005390_skeleton_phenotype0.80119347
122MP0001905_abnormal_dopamine_level0.79383791
123MP0002722_abnormal_immune_system0.79361913
124MP0008775_abnormal_heart_ventricle0.78870695
125MP0001873_stomach_inflammation0.78404192
126MP0004043_abnormal_pH_regulation0.77151431
127MP0002163_abnormal_gland_morphology0.76969891
128MP0005666_abnormal_adipose_tissue0.76572123
129MP0005075_abnormal_melanosome_morpholog0.76146690
130MP0000049_abnormal_middle_ear0.74279970
131MP0000689_abnormal_spleen_morphology0.73978926
132MP0005319_abnormal_enzyme/_coenzyme0.72672560
133MP0002736_abnormal_nociception_after0.71822494
134MP0002080_prenatal_lethality0.71761643
135MP0000759_abnormal_skeletal_muscle0.71753407
136MP0005380_embryogenesis_phenotype0.71715673
137MP0001672_abnormal_embryogenesis/_devel0.71715673
138MP0000604_amyloidosis0.71466635
139MP0000428_abnormal_craniofacial_morphol0.70602883
140MP0002088_abnormal_embryonic_growth/wei0.70476354
141MP0001697_abnormal_embryo_size0.70289580
142MP0005023_abnormal_wound_healing0.69255593
143MP0006292_abnormal_olfactory_placode0.69108345
144MP0003984_embryonic_growth_retardation0.68630249
145MP0002019_abnormal_tumor_incidence0.67960794
146MP0005084_abnormal_gallbladder_morpholo0.67827005
147MP0008875_abnormal_xenobiotic_pharmacok0.67384943
148MP0006072_abnormal_retinal_apoptosis0.66898887
149MP0002972_abnormal_cardiac_muscle0.66791488
150MP0002127_abnormal_cardiovascular_syste0.66539662
151MP0008873_increased_physiological_sensi0.66536731
152MP0002429_abnormal_blood_cell0.66340545
153MP0000647_abnormal_sebaceous_gland0.66195847
154MP0000685_abnormal_immune_system0.65892481
155MP0002269_muscular_atrophy0.65359641
156MP0000858_altered_metastatic_potential0.64303905
157MP0005369_muscle_phenotype0.64137007
158MP0003448_altered_tumor_morphology0.63706197
159MP0005389_reproductive_system_phenotype0.63639040
160MP0004130_abnormal_muscle_cell0.63578660
161MP0005410_abnormal_fertilization0.63055198
162MP0002877_abnormal_melanocyte_morpholog0.61877007

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.84358662
2Abnormal number of erythroid precursors (HP:0012131)4.67781482
3Reticulocytopenia (HP:0001896)4.50915368
4Decreased activity of mitochondrial respiratory chain (HP:0008972)4.47301767
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.47301767
6Macrocytic anemia (HP:0001972)4.32756836
7Testicular atrophy (HP:0000029)4.08168783
8Hepatocellular necrosis (HP:0001404)3.76385260
9Hepatic necrosis (HP:0002605)3.67481028
10Mitochondrial inheritance (HP:0001427)3.61266935
11Stomatitis (HP:0010280)3.58123189
12Acute necrotizing encephalopathy (HP:0006965)3.54212839
13Abnormal hemoglobin (HP:0011902)3.51689067
14Aplastic anemia (HP:0001915)3.47139618
15Concave nail (HP:0001598)3.45600945
16Abnormal mitochondria in muscle tissue (HP:0008316)3.33343914
17Ventricular tachycardia (HP:0004756)3.32221773
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.29417211
19Elevated erythrocyte sedimentation rate (HP:0003565)3.29126804
20Pallor (HP:0000980)3.25536774
21Acute encephalopathy (HP:0006846)3.24971901
22IgG deficiency (HP:0004315)3.22002750
23Exertional dyspnea (HP:0002875)3.17285687
24Increased IgM level (HP:0003496)3.16399473
25Aplasia/Hypoplasia of the sacrum (HP:0008517)3.13185975
26Progressive muscle weakness (HP:0003323)3.11134965
27Increased CSF lactate (HP:0002490)3.10970005
28Increased intramyocellular lipid droplets (HP:0012240)3.06806777
293-Methylglutaconic aciduria (HP:0003535)3.04049727
30Abnormality of liposaccharide metabolism (HP:0010968)3.01770589
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.01770589
32Abnormality of glycolipid metabolism (HP:0010969)3.01770589
33Sudden death (HP:0001699)2.95651279
34Myositis (HP:0100614)2.95480275
35Cerebral hypomyelination (HP:0006808)2.93805540
36Increased muscle lipid content (HP:0009058)2.92157719
37Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.91833181
38Progressive external ophthalmoplegia (HP:0000590)2.87920291
39Increased hepatocellular lipid droplets (HP:0006565)2.85537778
40Multiple enchondromatosis (HP:0005701)2.84565089
41Recurrent abscess formation (HP:0002722)2.81645584
42Increased serum lactate (HP:0002151)2.79891790
43Abnormality of macrophages (HP:0004311)2.78370547
44Muscle fiber splitting (HP:0003555)2.78362168
45Lipid accumulation in hepatocytes (HP:0006561)2.75996899
46Breast hypoplasia (HP:0003187)2.74339851
47Respiratory failure (HP:0002878)2.71491194
48Progressive macrocephaly (HP:0004481)2.69544290
49Mediastinal lymphadenopathy (HP:0100721)2.66690885
50Cerebral edema (HP:0002181)2.65066941
51Renal Fanconi syndrome (HP:0001994)2.64197456
52Secondary amenorrhea (HP:0000869)2.62369466
53Severe combined immunodeficiency (HP:0004430)2.57448112
54Rhabdomyolysis (HP:0003201)2.54876489
55Recurrent bacterial skin infections (HP:0005406)2.51891350
56Lactic acidosis (HP:0003128)2.50618558
57Encephalitis (HP:0002383)2.49241574
58Exercise intolerance (HP:0003546)2.48148241
59Panhypogammaglobulinemia (HP:0003139)2.47604179
60Microretrognathia (HP:0000308)2.47056998
61Abnormality of fatty-acid metabolism (HP:0004359)2.46960524
62Generalized aminoaciduria (HP:0002909)2.46649292
63Petechiae (HP:0000967)2.45548586
64Abnormality of T cells (HP:0002843)2.43346103
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.42253868
66Oral leukoplakia (HP:0002745)2.41887688
67Abnormality of renal resorption (HP:0011038)2.39928792
68Pancytopenia (HP:0001876)2.39030662
69Obstructive lung disease (HP:0006536)2.34864370
70Chronic obstructive pulmonary disease (HP:0006510)2.34864370
71Recurrent fungal infections (HP:0002841)2.34573775
72Type I transferrin isoform profile (HP:0003642)2.33500174
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30070480
74Dicarboxylic aciduria (HP:0003215)2.30070480
75Lipoatrophy (HP:0100578)2.28464102
76Orchitis (HP:0100796)2.27406428
77Dilated cardiomyopathy (HP:0001644)2.27171166
78Combined immunodeficiency (HP:0005387)2.26709346
79CNS demyelination (HP:0007305)2.25661372
80Increased serum pyruvate (HP:0003542)2.24900577
81Abnormality of glycolysis (HP:0004366)2.24900577
82Retrobulbar optic neuritis (HP:0100654)2.24582430
83Optic neuritis (HP:0100653)2.24582430
84Eczematoid dermatitis (HP:0000976)2.23573112
85Hyperglycinemia (HP:0002154)2.22921610
86T lymphocytopenia (HP:0005403)2.20758933
87Lethargy (HP:0001254)2.19672052
88Abnormality of T cell physiology (HP:0011840)2.16491618
89Pustule (HP:0200039)2.14964044
90Trismus (HP:0000211)2.14738822
91Increased serum ferritin (HP:0003281)2.13585423
92Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13568571
93Progressive microcephaly (HP:0000253)2.13082443
94Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10119712
95Abnormal protein N-linked glycosylation (HP:0012347)2.10119712
96Abnormal protein glycosylation (HP:0012346)2.10119712
97Abnormal glycosylation (HP:0012345)2.10119712
98Hyperglycinuria (HP:0003108)2.09146814
99Rough bone trabeculation (HP:0100670)2.08152977
100Optic disc pallor (HP:0000543)2.07754920
101Areflexia of lower limbs (HP:0002522)2.05508972
102Ragged-red muscle fibers (HP:0003200)2.03435864
103Premature rupture of membranes (HP:0001788)2.03066106
104Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.02753155
105Abnormality of aromatic amino acid family metabolism (HP:0004338)2.02210244
106Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99553890
107Hypertensive crisis (HP:0100735)1.99239055
108Atrioventricular block (HP:0001678)1.98668623
109Carpal bone hypoplasia (HP:0001498)1.98580859
110Abnormality of iron homeostasis (HP:0011031)1.98545665
111Purpura (HP:0000979)1.98312598
112Triphalangeal thumb (HP:0001199)1.97692357
113Opisthotonus (HP:0002179)1.97257389
114Respiratory difficulties (HP:0002880)1.96967379
115Abnormality of T cell number (HP:0011839)1.95986760
116Aplasia/Hypoplasia of the patella (HP:0006498)1.95625911
117Abnormality of serine family amino acid metabolism (HP:0010894)1.94906758
118Abnormality of glycine metabolism (HP:0010895)1.94906758
119Birth length less than 3rd percentile (HP:0003561)1.93591189
120Aplasia/hypoplasia of the uterus (HP:0008684)1.92587619
121Cerebral palsy (HP:0100021)1.92425518
122Achilles tendon contracture (HP:0001771)1.92160669
123Constricted visual fields (HP:0001133)1.91901659
124Abnormal delayed hypersensitivity skin test (HP:0002963)1.90290613
125Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90223075
126Brushfield spots (HP:0001088)1.90165601
127Vacuolated lymphocytes (HP:0001922)1.88593774
128Nausea (HP:0002018)1.88512544
129Entropion (HP:0000621)1.88410074
130Decreased subcutaneous fat (HP:0001002)1.88074182
131Premature ovarian failure (HP:0008209)1.87793321
132Horseshoe kidney (HP:0000085)1.86724582
133Recurrent skin infections (HP:0001581)1.86496308
134Progressive neurologic deterioration (HP:0002344)1.86035966
135Microvesicular hepatic steatosis (HP:0001414)1.84687224
136Hepatosplenomegaly (HP:0001433)1.84416952
137Recurrent cutaneous fungal infections (HP:0011370)1.84324617
138Chronic mucocutaneous candidiasis (HP:0002728)1.84324617
139Meningitis (HP:0001287)1.84311638
140Delayed CNS myelination (HP:0002188)1.84139182
141Patellar aplasia (HP:0006443)1.83597017
142Methylmalonic aciduria (HP:0012120)1.81495689
143Calf muscle hypertrophy (HP:0008981)1.80318996
144Seborrheic dermatitis (HP:0001051)1.79819357
145Abnormality of the Achilles tendon (HP:0005109)1.79301635
146Sparse lateral eyebrow (HP:0005338)1.78560673
147Congenital, generalized hypertrichosis (HP:0004540)1.78033347
148Redundant skin (HP:0001582)1.77761395
149Palpitations (HP:0001962)1.76796511
150Ileus (HP:0002595)1.76197719
151Muscle hypertrophy of the lower extremities (HP:0008968)1.75843598
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.73514431
153Emotional lability (HP:0000712)1.71706209
154Abnormality of serum amino acid levels (HP:0003112)1.68661892
155Abnormality of urine glucose concentration (HP:0011016)1.68415376
156Glycosuria (HP:0003076)1.68415376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.04887288
2NME24.20205776
3TAOK33.78498440
4STK163.70105292
5VRK23.35844267
6BUB13.28510186
7TESK23.06004725
8TXK2.88936235
9EIF2AK12.63938863
10GRK62.21061299
11DYRK32.20040553
12TAOK22.11328710
13WEE12.10438493
14PIM22.01496107
15KDR1.98960761
16TIE11.94125628
17SRPK11.80227551
18IKBKB1.71774348
19MAP3K141.54692421
20PRPF4B1.50969596
21IRAK31.50018399
22MAP3K101.47880390
23PBK1.45944295
24MKNK21.42876026
25IKBKE1.40809972
26MAP3K111.37537582
27BMPR1B1.36914842
28BCKDK1.35429948
29ILK1.30330582
30LIMK11.27544879
31SCYL21.27510720
32NME11.23516526
33ACVR1B1.21653153
34PHKG11.18913540
35PHKG21.18913540
36NEK21.15207238
37CDK71.12177935
38FES1.10159177
39TTK1.09400075
40CDK191.08126559
41DAPK31.07118245
42DYRK1B1.06333517
43RPS6KA41.05327246
44MAP3K31.05295294
45DMPK1.03969599
46MYLK1.03468267
47TTN1.02507973
48CSK1.01215641
49LRRK20.99669525
50MATK0.99219778
51AURKA0.97080818
52CSF1R0.96652819
53TESK10.96516402
54TNK20.96366752
55MST40.95855035
56TEC0.94984835
57LYN0.93986759
58TAOK10.93973292
59AURKB0.93945161
60TRIB30.93332840
61ITK0.92273140
62MAP4K10.91538544
63MAP2K30.90451826
64ADRBK20.90051981
65IRAK20.89952357
66EIF2AK30.89539128
67MAP3K120.89049247
68JAK30.88545253
69BLK0.87914758
70VRK10.86494433
71DYRK20.86426508
72PLK10.85632020
73TGFBR10.84175130
74RPS6KA50.83474222
75MUSK0.83148906
76MAP2K70.81692601
77LCK0.81373927
78DAPK10.81302201
79STK40.81178411
80ZAP700.80162288
81SYK0.79814542
82CDK40.78246730
83GRK70.76610124
84TBK10.74857558
85IRAK10.74574660
86MAPKAPK30.73897793
87PKN10.73096266
88MKNK10.72553936
89CDK80.71680684
90SIK30.70282859
91TYK20.70199344
92STK100.69507369
93ZAK0.67374472
94HCK0.67194041
95NUAK10.67171409
96PRKCQ0.66863887
97PAK10.65232318
98MAP3K80.62687543
99LATS20.61880248
100MAPK150.61819078
101CHUK0.60961844
102MAP2K20.60266384
103CHEK20.59691430
104PAK20.58911214
105NEK90.58192777
106IRAK40.57538799
107ERN10.56589937
108CCNB10.56253262
109BRAF0.55958021
110RPS6KB20.55522876
111PRKCI0.55176459
112GRK10.54882775
113MARK30.54741705
114CAMKK20.54195352
115TGFBR20.53953538
116STK390.53493790
117PRKD20.53057261
118PRKD10.52326870
119PKN20.52012467
120EIF2AK20.50179270
121OBSCN0.49010932
122KIT0.46980702
123MAPKAPK50.45761765
124EPHA20.45019449
125CAMK2D0.44122594
126NLK0.43534823
127MAP4K20.43398387
128SIK20.43375069
129BRSK20.42898573
130PIM10.41860849
131MAPKAPK20.41720883
132CSNK2A10.40319913
133CSNK1G30.40202383
134PDK40.39972195
135PDK30.39972195
136MAP3K50.38750854
137MAP3K10.37670750
138EPHB20.37407330
139ABL20.37098381
140BRD40.36818912
141ABL10.36545122
142BTK0.36443255
143WNK40.36246172
144CSNK2A20.34300886
145ADRBK10.31354346
146ARAF0.29019781
147PRKCD0.28390662
148RPS6KA60.27756523
149SMG10.25180956
150RIPK40.24417947
151RPS6KC10.24112954
152RPS6KL10.24112954

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.67282414
2RNA polymerase_Homo sapiens_hsa030203.68204210
3Sulfur relay system_Homo sapiens_hsa041222.77278333
4Proteasome_Homo sapiens_hsa030502.69278455
5DNA replication_Homo sapiens_hsa030302.62671998
6Oxidative phosphorylation_Homo sapiens_hsa001902.58079166
7Spliceosome_Homo sapiens_hsa030402.46837726
8Parkinsons disease_Homo sapiens_hsa050122.42069665
9Pyrimidine metabolism_Homo sapiens_hsa002402.30671132
10Homologous recombination_Homo sapiens_hsa034402.18397249
11Allograft rejection_Homo sapiens_hsa053302.15504664
12Folate biosynthesis_Homo sapiens_hsa007902.05324160
13Protein export_Homo sapiens_hsa030602.02808173
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95235095
15Graft-versus-host disease_Homo sapiens_hsa053321.94320462
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91904628
17Autoimmune thyroid disease_Homo sapiens_hsa053201.88285928
18Mismatch repair_Homo sapiens_hsa034301.85688602
19Huntingtons disease_Homo sapiens_hsa050161.83511343
20Vitamin B6 metabolism_Homo sapiens_hsa007501.73475622
21Basal transcription factors_Homo sapiens_hsa030221.57710429
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54129354
23Nucleotide excision repair_Homo sapiens_hsa034201.53399141
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51601144
25Asthma_Homo sapiens_hsa053101.51085192
26Type I diabetes mellitus_Homo sapiens_hsa049401.50592960
27Base excision repair_Homo sapiens_hsa034101.48156768
28Alzheimers disease_Homo sapiens_hsa050101.47025836
29RNA transport_Homo sapiens_hsa030131.41756735
30Rheumatoid arthritis_Homo sapiens_hsa053231.41692757
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38729932
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.38147201
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.36734309
34Pentose phosphate pathway_Homo sapiens_hsa000301.32968129
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32644631
36Cardiac muscle contraction_Homo sapiens_hsa042601.31832905
37Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.30815643
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.30441447
39Purine metabolism_Homo sapiens_hsa002301.28766276
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.28469430
41Leishmaniasis_Homo sapiens_hsa051401.25891596
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25355958
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24766602
44p53 signaling pathway_Homo sapiens_hsa041151.20454183
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20231195
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.20156524
47Cell cycle_Homo sapiens_hsa041101.14265997
48Shigellosis_Homo sapiens_hsa051311.11869566
49Legionellosis_Homo sapiens_hsa051341.11759608
50Viral myocarditis_Homo sapiens_hsa054161.08012753
51Fatty acid degradation_Homo sapiens_hsa000711.07953711
52Carbon metabolism_Homo sapiens_hsa012001.07281699
53Osteoclast differentiation_Homo sapiens_hsa043801.06834321
54Fanconi anemia pathway_Homo sapiens_hsa034601.06668861
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06036549
56Propanoate metabolism_Homo sapiens_hsa006401.04706403
57Measles_Homo sapiens_hsa051621.01438400
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01408727
59One carbon pool by folate_Homo sapiens_hsa006701.01371649
60T cell receptor signaling pathway_Homo sapiens_hsa046600.99203084
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94785916
62Glutathione metabolism_Homo sapiens_hsa004800.92776690
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90562899
64Tuberculosis_Homo sapiens_hsa051520.89027924
65Lysosome_Homo sapiens_hsa041420.88380444
66Fatty acid elongation_Homo sapiens_hsa000620.87025253
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86719100
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.86327276
69Malaria_Homo sapiens_hsa051440.86086580
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85245865
71Arginine and proline metabolism_Homo sapiens_hsa003300.83942309
72Collecting duct acid secretion_Homo sapiens_hsa049660.82762263
73Biosynthesis of amino acids_Homo sapiens_hsa012300.81968401
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.81826913
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80691443
76RNA degradation_Homo sapiens_hsa030180.78741457
77Salmonella infection_Homo sapiens_hsa051320.78554380
78TNF signaling pathway_Homo sapiens_hsa046680.78204087
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.77795784
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74989846
81Linoleic acid metabolism_Homo sapiens_hsa005910.73108099
82Butanoate metabolism_Homo sapiens_hsa006500.71745586
83Staphylococcus aureus infection_Homo sapiens_hsa051500.71191338
84B cell receptor signaling pathway_Homo sapiens_hsa046620.71107445
85Primary immunodeficiency_Homo sapiens_hsa053400.70940064
86Systemic lupus erythematosus_Homo sapiens_hsa053220.69867563
87Epstein-Barr virus infection_Homo sapiens_hsa051690.69568293
88Peroxisome_Homo sapiens_hsa041460.68280580
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68136801
90Pyruvate metabolism_Homo sapiens_hsa006200.66078328
91Metabolic pathways_Homo sapiens_hsa011000.64961437
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62794364
93Arachidonic acid metabolism_Homo sapiens_hsa005900.61997028
94Antigen processing and presentation_Homo sapiens_hsa046120.61655196
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.61418736
96Influenza A_Homo sapiens_hsa051640.61327783
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61292157
98Pertussis_Homo sapiens_hsa051330.60418971
99Retinol metabolism_Homo sapiens_hsa008300.60090423
100Fructose and mannose metabolism_Homo sapiens_hsa000510.60013535
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.59177806
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.57393226
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57098167
104Bladder cancer_Homo sapiens_hsa052190.55289346
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55183764
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.52948568
107Jak-STAT signaling pathway_Homo sapiens_hsa046300.50681256
108Sulfur metabolism_Homo sapiens_hsa009200.50019660
109beta-Alanine metabolism_Homo sapiens_hsa004100.49220795
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49055508
111Toxoplasmosis_Homo sapiens_hsa051450.48432699
112Other glycan degradation_Homo sapiens_hsa005110.48303972
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47778932
114Herpes simplex infection_Homo sapiens_hsa051680.45348237
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44765222
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43627610
117Selenocompound metabolism_Homo sapiens_hsa004500.43110781
118Tryptophan metabolism_Homo sapiens_hsa003800.40899732
119Phagosome_Homo sapiens_hsa041450.39873336
120Regulation of autophagy_Homo sapiens_hsa041400.39744033
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38253266
122Hepatitis B_Homo sapiens_hsa051610.37407342
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37060712
124Galactose metabolism_Homo sapiens_hsa000520.34864601
125Fat digestion and absorption_Homo sapiens_hsa049750.34561250
126Chemical carcinogenesis_Homo sapiens_hsa052040.33673344
127Fatty acid metabolism_Homo sapiens_hsa012120.32993232
128Hematopoietic cell lineage_Homo sapiens_hsa046400.32630586
129Viral carcinogenesis_Homo sapiens_hsa052030.32171333
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.30173802
131HTLV-I infection_Homo sapiens_hsa051660.29472280
132PPAR signaling pathway_Homo sapiens_hsa033200.29024156
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.28598302
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28496389
135Tyrosine metabolism_Homo sapiens_hsa003500.27161653
136Acute myeloid leukemia_Homo sapiens_hsa052210.26592164
137Histidine metabolism_Homo sapiens_hsa003400.26349774
138Vitamin digestion and absorption_Homo sapiens_hsa049770.26215031
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25694292
140Small cell lung cancer_Homo sapiens_hsa052220.22659636
141Sphingolipid metabolism_Homo sapiens_hsa006000.21651196
142HIF-1 signaling pathway_Homo sapiens_hsa040660.20682637
143Caffeine metabolism_Homo sapiens_hsa002320.20604100
144Apoptosis_Homo sapiens_hsa042100.20140720

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