LELP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.77045398
2epithelial cilium movement (GO:0003351)9.57554424
3axonemal dynein complex assembly (GO:0070286)9.38451215
4motile cilium assembly (GO:0044458)9.27330965
5reproduction (GO:0000003)9.15010967
6regulation of cilium movement (GO:0003352)9.03646150
7response to pheromone (GO:0019236)8.79972595
8negative regulation of inclusion body assembly (GO:0090084)8.00384512
9cilium or flagellum-dependent cell motility (GO:0001539)7.89754206
10cilium movement (GO:0003341)7.65558743
11sperm capacitation (GO:0048240)7.28811627
12single fertilization (GO:0007338)7.27363277
13rRNA methylation (GO:0031167)7.10975746
14spermatogenesis (GO:0007283)7.10442746
15organic cation transport (GO:0015695)7.09878793
16male gamete generation (GO:0048232)7.07831749
17phosphatidylethanolamine biosynthetic process (GO:0006646)7.06579493
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.01223016
19synaptonemal complex organization (GO:0070193)6.93001564
20microtubule depolymerization (GO:0007019)6.83195016
21synaptonemal complex assembly (GO:0007130)6.78078119
22male meiosis (GO:0007140)6.57753201
23regulation of inclusion body assembly (GO:0090083)6.57028330
24phosphatidylethanolamine metabolic process (GO:0046337)6.51981067
25gamete generation (GO:0007276)6.50062209
26piRNA metabolic process (GO:0034587)6.39761905
27fertilization (GO:0009566)6.23345627
28chromosome condensation (GO:0030261)6.18595766
29cellular ketone body metabolic process (GO:0046950)6.06220008
30protein targeting to Golgi (GO:0000042)6.01764975
31rRNA modification (GO:0000154)5.99758541
32calcium ion-dependent exocytosis (GO:0017156)5.86122451
33DNA packaging (GO:0006323)5.82403547
34establishment of protein localization to Golgi (GO:0072600)5.76961816
35retrograde transport, vesicle recycling within Golgi (GO:0000301)5.60547497
36germ cell development (GO:0007281)5.56470791
37glycerol ether metabolic process (GO:0006662)5.51274890
38cellular process involved in reproduction in multicellular organism (GO:0022412)5.41869745
39regulation of microtubule-based movement (GO:0060632)5.37946446
40ketone body metabolic process (GO:1902224)5.35372421
41spermatid nucleus differentiation (GO:0007289)5.19029106
42multicellular organismal reproductive process (GO:0048609)5.12409882
43ether metabolic process (GO:0018904)5.09548340
44ventricular system development (GO:0021591)5.02711943
45cell recognition (GO:0008037)5.02453365
46positive regulation of Rab GTPase activity (GO:0032851)4.92457445
47regulation of Rab GTPase activity (GO:0032313)4.92457445
48sexual reproduction (GO:0019953)4.81217446
49centriole replication (GO:0007099)4.78456174
50microtubule severing (GO:0051013)4.73092657
51seminiferous tubule development (GO:0072520)4.69309970
52male meiosis I (GO:0007141)4.68153030
53antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.67978920
54regulation of transcription involved in cell fate commitment (GO:0060850)4.58015540
55chromosome organization involved in meiosis (GO:0070192)4.53499660
56single strand break repair (GO:0000012)4.42168741
57chaperone-mediated protein complex assembly (GO:0051131)4.39012509
58left/right pattern formation (GO:0060972)4.35557466
59centriole assembly (GO:0098534)4.32024550
60protein localization to Golgi apparatus (GO:0034067)4.28743340
61multicellular organismal development (GO:0007275)4.13711356
62DNA methylation involved in gamete generation (GO:0043046)4.11357592
63meiotic nuclear division (GO:0007126)3.95958968
64coenzyme catabolic process (GO:0009109)3.82475647
65protein-DNA complex disassembly (GO:0032986)3.79885415
66nucleosome disassembly (GO:0006337)3.79885415
67regulation of centriole replication (GO:0046599)3.74666874
68response to acidic pH (GO:0010447)3.73295358
69sequestering of actin monomers (GO:0042989)3.72560240
70meiosis I (GO:0007127)3.72301144
71negative regulation of Rho protein signal transduction (GO:0035024)3.71885368
72peptidyl-threonine dephosphorylation (GO:0035970)3.66583528
73protein refolding (GO:0042026)3.53477870
74protein polyglutamylation (GO:0018095)3.52028916
75musculoskeletal movement (GO:0050881)3.51452693
76multicellular organismal movement (GO:0050879)3.51452693
77regulation of somitogenesis (GO:0014807)3.50340064
78genitalia morphogenesis (GO:0035112)3.50115985
79microtubule polymerization or depolymerization (GO:0031109)3.48680485
80regulation of spindle checkpoint (GO:0090231)3.45984033
81cellular response to pH (GO:0071467)3.41237216
82glycolytic process (GO:0006096)3.40250604
83regulation of interleukin-13 production (GO:0032656)3.39590336
84cerebral cortex neuron differentiation (GO:0021895)3.38533548
85homeostasis of number of cells within a tissue (GO:0048873)3.33748499
86negative regulation of gene expression, epigenetic (GO:0045814)3.31176557
87regulation of T-helper 2 cell differentiation (GO:0045628)3.28951632
88cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.25965102
89protein K11-linked deubiquitination (GO:0035871)3.24742812
90nucleus organization (GO:0006997)3.23614866
91cranial nerve morphogenesis (GO:0021602)3.22139179
92polyamine biosynthetic process (GO:0006596)3.20985810
93mitotic sister chromatid cohesion (GO:0007064)3.20136151
94histone H3-K9 demethylation (GO:0033169)3.14784114
95meiotic cell cycle (GO:0051321)3.14626264
96carnitine transport (GO:0015879)3.13450347
97amino-acid betaine transport (GO:0015838)3.13450347
98RNA destabilization (GO:0050779)3.11893487
99RNA localization (GO:0006403)3.11435008
100interferon-gamma secretion (GO:0072643)3.10980375
101DNA conformation change (GO:0071103)3.06881637
102nucleoside diphosphate phosphorylation (GO:0006165)3.06500746
103positive regulation of macrophage activation (GO:0043032)3.04390171
104protein depolymerization (GO:0051261)3.04376411
105chromatin silencing (GO:0006342)2.96473545
106polyol catabolic process (GO:0046174)2.95027868
107mitochondrial fission (GO:0000266)2.91988400
108carnitine transmembrane transport (GO:1902603)2.91971541
109mitochondrion degradation (GO:0000422)2.90710259
110mesenchymal cell differentiation involved in kidney development (GO:0072161)2.89237353
111mesenchymal cell differentiation involved in renal system development (GO:2001012)2.89237353
112protein localization to cilium (GO:0061512)2.88620132
113alditol metabolic process (GO:0019400)2.87880412
114negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.86187195
115tooth mineralization (GO:0034505)2.85060242
116regulation of phosphoprotein phosphatase activity (GO:0043666)2.84701165
117regulation of cilium assembly (GO:1902017)2.82445320
118negative regulation of histone methylation (GO:0031061)2.82381068
119mitotic G1 DNA damage checkpoint (GO:0031571)2.80473156
120GTP biosynthetic process (GO:0006183)2.79771273
121monoubiquitinated protein deubiquitination (GO:0035520)2.78434008
122positive regulation of skeletal muscle tissue development (GO:0048643)2.78407333
123cell differentiation involved in metanephros development (GO:0072202)2.77054016
124positive regulation of glycolytic process (GO:0045821)2.74990583
125membrane protein intracellular domain proteolysis (GO:0031293)2.66217613
126meiotic cell cycle process (GO:1903046)2.65496866
127cilium organization (GO:0044782)2.62175430
128synapsis (GO:0007129)2.58134734
129microtubule-based movement (GO:0007018)2.57690231
130cellular component assembly involved in morphogenesis (GO:0010927)2.51797041
131cilium assembly (GO:0042384)2.51410348
132UTP biosynthetic process (GO:0006228)2.50780546
133cilium morphogenesis (GO:0060271)2.49178372
134peptidyl-glutamic acid modification (GO:0018200)2.45300167
135lactate metabolic process (GO:0006089)2.41844579
136axoneme assembly (GO:0035082)2.39665640
137negative regulation of organelle assembly (GO:1902116)2.38629349
138sperm motility (GO:0030317)14.8783407
139acrosome reaction (GO:0007340)12.9518989
140fusion of sperm to egg plasma membrane (GO:0007342)12.8278594
141cell wall macromolecule catabolic process (GO:0016998)12.5381386
142cell wall macromolecule metabolic process (GO:0044036)12.5381386
143sperm-egg recognition (GO:0035036)11.5688600
144acrosome assembly (GO:0001675)11.3456768
145binding of sperm to zona pellucida (GO:0007339)10.6074805
146multicellular organism reproduction (GO:0032504)10.3895197
147cell-cell recognition (GO:0009988)10.3526907
148spermatid development (GO:0007286)10.1171155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.73175471
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.97122928
3EZH2_22144423_ChIP-Seq_EOC_Human4.48827953
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.69134034
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.55918172
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.25719566
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.91921779
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.79786067
9VDR_22108803_ChIP-Seq_LS180_Human2.73877301
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41764546
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.35742116
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.26368936
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.22645889
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08229382
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06210051
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05725749
17ZNF274_21170338_ChIP-Seq_K562_Hela2.05627952
18ERA_21632823_ChIP-Seq_H3396_Human1.96595046
19DROSHA_22980978_ChIP-Seq_HELA_Human1.93821417
20CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93733574
21FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85719709
22* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.83132212
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.78786929
24* NANOG_20526341_ChIP-Seq_ESCs_Human1.77606298
25* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77316754
26* RAC3_21632823_ChIP-Seq_H3396_Human1.76611025
27SOX2_22085726_ChIP-Seq_NPCs_Mouse1.75292565
28MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.75210266
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.74251928
30STAT1_17558387_ChIP-Seq_HELA_Human1.72458325
31SMC4_20622854_ChIP-Seq_HELA_Human1.70953872
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.68677780
33TAF2_19829295_ChIP-Seq_ESCs_Human1.66079898
34P68_20966046_ChIP-Seq_HELA_Human1.65644434
35TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.64428971
36FUS_26573619_Chip-Seq_HEK293_Human1.63672098
37LXR_22292898_ChIP-Seq_THP-1_Human1.61796568
38GATA3_21867929_ChIP-Seq_CD8_Mouse1.60536860
39* E2F1_20622854_ChIP-Seq_HELA_Human1.58722463
40TP63_22573176_ChIP-Seq_HFKS_Human1.55772300
41FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.55012103
42AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52518744
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52255698
44OCT4_20526341_ChIP-Seq_ESCs_Human1.50635377
45GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.50457086
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.50182730
47WDR5_24793694_ChIP-Seq_LNCAP_Human1.49091333
48MYC_19829295_ChIP-Seq_ESCs_Human1.49032723
49PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.47332216
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.44596136
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.44493400
52ER_23166858_ChIP-Seq_MCF-7_Human1.41558016
53SMAD4_21741376_ChIP-Seq_EPCs_Human1.41168977
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40116055
55CBP_20019798_ChIP-Seq_JUKART_Human1.40116055
56* TDRD3_21172665_ChIP-Seq_MCF-7_Human1.39983473
57KDM2B_26808549_Chip-Seq_REH_Human1.39956152
58SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38844571
59REST_21632747_ChIP-Seq_MESCs_Mouse1.36327166
60LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36244851
61SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36121720
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35935785
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35522456
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.35374172
65* P300_27268052_Chip-Seq_Bcells_Human1.35096402
66* P53_21459846_ChIP-Seq_SAOS-2_Human1.33600269
67SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33419447
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32148449
69KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.30734115
70RAD21_21589869_ChIP-Seq_MESCs_Mouse1.30330778
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30018318
72SMAD3_21741376_ChIP-Seq_ESCs_Human1.29043611
73TP53_18474530_ChIP-ChIP_U2OS_Human1.28997403
74CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28897084
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.28890420
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28852492
77* AR_25329375_ChIP-Seq_VCAP_Human1.27643136
78GATA3_21867929_ChIP-Seq_TH1_Mouse1.27303839
79RUNX_20019798_ChIP-Seq_JUKART_Human1.26228012
80GF1_26923725_Chip-Seq_HPCs_Mouse1.26142153
81SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25669807
82* P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.24769987
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24731614
84CEBPB_22108803_ChIP-Seq_LS180_Human1.24625194
85CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.23182615
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22610004
87* HNFA_21074721_ChIP-Seq_CACO-2_Human1.21822725
88* RBPJ_21746931_ChIP-Seq_IB4_Human1.21494461
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.20751681
90* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.20502268
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20280909
92RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19965082
93KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19719346
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.19595791
95SPI1_26923725_Chip-Seq_HPCs_Mouse1.19397260
96TET1_21451524_ChIP-Seq_MESCs_Mouse1.19244414
97SA1_27219007_Chip-Seq_Bcells_Human1.18926539
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18765629
99* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.18597474
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18147988
101MYC_27129775_Chip-Seq_CORNEA_Mouse1.17973888
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.16396816
103EZH2_27294783_Chip-Seq_ESCs_Mouse1.16312692
104PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15942376
105JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.15698959
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15603300
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15307849
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15307849
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.14218299
110SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13404714
111* ETV1_20927104_ChIP-Seq_GIST48_Human1.12416993
112TAF15_26573619_Chip-Seq_HEK293_Human1.12034745
113GATA1_19941827_ChIP-Seq_MEL86_Mouse1.11899129
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11790665
115CTCF_20526341_ChIP-Seq_ESCs_Human1.11431628
116CBX2_27304074_Chip-Seq_ESCs_Mouse1.11254889
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09797829
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.09444678
119NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09443791
120RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08741722
121TBL1_22424771_ChIP-Seq_293T_Human1.08486684
122P300_19829295_ChIP-Seq_ESCs_Human1.07450663
123* SMRT_27268052_Chip-Seq_Bcells_Human1.07354960
124SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07111103
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06713261
126SA1_27219007_Chip-Seq_ERYTHROID_Human1.06341717
127NFE2_27457419_Chip-Seq_LIVER_Mouse1.06271792
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.06200044
129TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06041092
130RUNX1_26923725_Chip-Seq_HPCs_Mouse1.05872716
131ESET_19884257_ChIP-Seq_ESCs_Mouse1.05681590
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05574062
133EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05093947
134THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04344128
135PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03917088
136TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03729102
137SOX11_22085726_ChIP-Seq_ESNs_Mouse1.03437128
138SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01070535
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.99971025
140OCT4_19829295_ChIP-Seq_ESCs_Human0.99477117
141* ERG_20517297_ChIP-Seq_VCAP_Human0.98823118
142NANOG_19829295_ChIP-Seq_ESCs_Human0.98067109
143SOX2_19829295_ChIP-Seq_ESCs_Human0.98067109
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.97877321
145SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97804193
146KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96069635
147MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95715083
148LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.95387212
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93750763
150CRX_20693478_ChIP-Seq_RETINA_Mouse0.93411408
151* BCOR_27268052_Chip-Seq_Bcells_Human0.93160968
152FLI1_21867929_ChIP-Seq_CD8_Mouse0.92940097
153* YY1_22570637_ChIP-Seq_MALME-3M_Human0.92712099
154NFYB_21822215_ChIP-Seq_K562_Human0.92085835
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91648965
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91594534
157NANOG_18555785_Chip-Seq_ESCs_Mouse0.91523075
158BCL6_27268052_Chip-Seq_Bcells_Human0.90617992
159CTCF_27219007_Chip-Seq_Bcells_Human0.89747671
160SOX2_21211035_ChIP-Seq_LN229_Human0.88418717
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86719335
162ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86670763
163SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86601047
164PHF8_20622854_ChIP-Seq_HELA_Human0.86565603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.04314681
2MP0001929_abnormal_gametogenesis5.48318702
3MP0008877_abnormal_DNA_methylation3.66526739
4MP0002161_abnormal_fertility/fecundity3.31191897
5MP0005670_abnormal_white_adipose3.30567824
6MP0002210_abnormal_sex_determination3.19398962
7MP0001145_abnormal_male_reproductive2.70738056
8MP0000678_abnormal_parathyroid_gland2.65861685
9MP0000653_abnormal_sex_gland2.32649595
10MP0003718_maternal_effect2.13702658
11MP0005410_abnormal_fertilization16.8949773
12MP0002132_abnormal_respiratory_system1.98259488
13MP0002653_abnormal_ependyma_morphology1.91655165
14MP0002249_abnormal_larynx_morphology1.68250266
15MP0005423_abnormal_somatic_nervous1.66412530
16MP0002822_catalepsy1.51502431
17MP0003646_muscle_fatigue1.49166732
18MP0005379_endocrine/exocrine_gland_phen1.46879416
19MP0009053_abnormal_anal_canal1.46261641
20MP0004233_abnormal_muscle_weight1.44443628
21MP0002160_abnormal_reproductive_system1.35927241
22MP0001485_abnormal_pinna_reflex1.34781236
23MP0005310_abnormal_salivary_gland1.33348325
24MP0004859_abnormal_synaptic_plasticity1.23112764
25MP0005623_abnormal_meninges_morphology1.22743648
26MP0001486_abnormal_startle_reflex1.22643713
27MP0002735_abnormal_chemical_nociception1.21282428
28MP0001765_abnormal_ion_homeostasis1.16575792
29MP0004510_myositis1.15472653
30MP0002138_abnormal_hepatobiliary_system1.14343430
31MP0002127_abnormal_cardiovascular_syste1.10964419
32MP0002282_abnormal_trachea_morphology1.10139220
33MP0001984_abnormal_olfaction1.01332537
34MP0005248_abnormal_Harderian_gland1.00221897
35MP0002234_abnormal_pharynx_morphology0.99878023
36MP0001963_abnormal_hearing_physiology0.99153937
37MP0005395_other_phenotype0.97910405
38MP0005451_abnormal_body_composition0.91574375
39MP0000026_abnormal_inner_ear0.89754136
40MP0000681_abnormal_thyroid_gland0.88721307
41MP0000955_abnormal_spinal_cord0.85592367
42MP0000049_abnormal_middle_ear0.79147202
43MP0005647_abnormal_sex_gland0.78132411
44MP0003115_abnormal_respiratory_system0.77953046
45MP0008995_early_reproductive_senescence0.77132915
46MP0001879_abnormal_lymphatic_vessel0.74619931
47MP0005666_abnormal_adipose_tissue0.69933768
48MP0002067_abnormal_sensory_capabilities0.69662710
49MP0005083_abnormal_biliary_tract0.69388057
50MP0005377_hearing/vestibular/ear_phenot0.67458423
51MP0003878_abnormal_ear_physiology0.67458423
52MP0002557_abnormal_social/conspecific_i0.67252699
53MP0003329_amyloid_beta_deposits0.66891609
54MP0005636_abnormal_mineral_homeostasis0.66799023
55MP0000516_abnormal_urinary_system0.65408040
56MP0005367_renal/urinary_system_phenotyp0.65408040
57MP0001905_abnormal_dopamine_level0.64561607
58MP0005389_reproductive_system_phenotype0.64546689
59MP0004085_abnormal_heartbeat0.64126819
60MP0003011_delayed_dark_adaptation0.63564097
61MP0009046_muscle_twitch0.61385963
62MP0002733_abnormal_thermal_nociception0.59912261
63MP0008058_abnormal_DNA_repair0.58682848
64MP0001666_abnormal_nutrient_absorption0.57918675
65MP0000613_abnormal_salivary_gland0.56513825
66MP0002736_abnormal_nociception_after0.55911704
67MP0004484_altered_response_of0.55088063
68MP0001764_abnormal_homeostasis0.54363850
69MP0004036_abnormal_muscle_relaxation0.54358591
70MP0000003_abnormal_adipose_tissue0.52794604
71MP0003077_abnormal_cell_cycle0.50464345
72MP0001324_abnormal_eye_pigmentation0.49562036
73MP0002269_muscular_atrophy0.49379863
74MP0000534_abnormal_ureter_morphology0.48942382
75MP0002272_abnormal_nervous_system0.47417256
76MP0002572_abnormal_emotion/affect_behav0.46449065
77MP0000569_abnormal_digit_pigmentation0.45980350
78MP0000249_abnormal_blood_vessel0.45212619
79MP0003137_abnormal_impulse_conducting0.44091498
80MP0003699_abnormal_female_reproductive0.43159525
81MP0003119_abnormal_digestive_system0.43133300
82MP0000358_abnormal_cell_content/0.43095107
83MP0009745_abnormal_behavioral_response0.43077972
84MP0001293_anophthalmia0.42680300
85MP0009278_abnormal_bone_marrow0.42278961
86MP0005397_hematopoietic_system_phenotyp0.42278867
87MP0001545_abnormal_hematopoietic_system0.42278867
88MP0003091_abnormal_cell_migration0.42101231
89MP0002734_abnormal_mechanical_nocicepti0.42056163
90MP0001440_abnormal_grooming_behavior0.41978949
91MP0003880_abnormal_central_pattern0.41844115
92MP0005535_abnormal_body_temperature0.41452451
93MP0001970_abnormal_pain_threshold0.41201827
94MP0009697_abnormal_copulation0.40909754
95MP0000470_abnormal_stomach_morphology0.39790362
96MP0005167_abnormal_blood-brain_barrier0.39742040
97MP0009115_abnormal_fat_cell0.39085569
98MP0001270_distended_abdomen0.38826367
99MP0006036_abnormal_mitochondrial_physio0.38598247
100MP0005253_abnormal_eye_physiology0.36390567
101MP0000604_amyloidosis0.35699555
102MP0003942_abnormal_urinary_system0.34965944
103MP0002139_abnormal_hepatobiliary_system0.34782222
104MP0003936_abnormal_reproductive_system0.34611131
105MP0002928_abnormal_bile_duct0.34310421
106MP0006292_abnormal_olfactory_placode0.33439044
107MP0000467_abnormal_esophagus_morphology0.33421352
108MP0001501_abnormal_sleep_pattern0.32805009
109MP0000566_synostosis0.32534132
110MP0005408_hypopigmentation0.32218090
111MP0005551_abnormal_eye_electrophysiolog0.32143909
112MP0001968_abnormal_touch/_nociception0.31904111
113MP0004133_heterotaxia0.30458755
114MP0003879_abnormal_hair_cell0.30023014
115MP0003950_abnormal_plasma_membrane0.29486550
116MP0004811_abnormal_neuron_physiology0.29314890
117MP0002971_abnormal_brown_adipose0.28981281
118MP0005391_vision/eye_phenotype0.28090956
119MP0002295_abnormal_pulmonary_circulatio0.27539493
120MP0003633_abnormal_nervous_system0.27489055
121MP0005375_adipose_tissue_phenotype0.26539722
122MP0003948_abnormal_gas_homeostasis0.24844822
123MP0001730_embryonic_growth_arrest0.24304977
124MP0002169_no_abnormal_phenotype0.24299405
125MP0001849_ear_inflammation0.24289074
126MP0002873_normal_phenotype0.24083897
127MP0004270_analgesia0.23377062
128MP0004742_abnormal_vestibular_system0.23056481
129MP0010094_abnormal_chromosome_stability0.22820965
130MP0003631_nervous_system_phenotype0.22520304
131MP0003861_abnormal_nervous_system0.22286545
132MP0003111_abnormal_nucleus_morphology0.21066242
133MP0002152_abnormal_brain_morphology0.20881155
134MP0000751_myopathy0.20637691
135MP0008961_abnormal_basal_metabolism0.19982099
136MP0004043_abnormal_pH_regulation0.18643706
137MP0004145_abnormal_muscle_electrophysio0.18140099
138MP0001119_abnormal_female_reproductive0.17985518
139MP0002909_abnormal_adrenal_gland0.17833353
140MP0008875_abnormal_xenobiotic_pharmacok0.17798633
141MP0004019_abnormal_vitamin_homeostasis0.17715776
142MP0006035_abnormal_mitochondrial_morpho0.17570300
143MP0001727_abnormal_embryo_implantation0.17523621
144MP0005365_abnormal_bile_salt0.16154371
145MP0008569_lethality_at_weaning0.15976492
146MP0002092_abnormal_eye_morphology0.15695094
147MP0002118_abnormal_lipid_homeostasis0.15442461
148MP0003959_abnormal_lean_body0.14763707
149MP0000462_abnormal_digestive_system0.14598874
150MP0000001_mammalian_phenotype0.14269692
151MP0002693_abnormal_pancreas_physiology0.14029883
152MP0001348_abnormal_lacrimal_gland0.13988875
153MP0002229_neurodegeneration0.13567958
154MP0005319_abnormal_enzyme/_coenzyme0.13434616
155MP0003787_abnormal_imprinting0.12576451
156MP0010329_abnormal_lipoprotein_level0.12403672
157MP0000920_abnormal_myelination0.12125624
158MP0004130_abnormal_muscle_cell0.11727591
159MP0008770_decreased_survivor_rate0.11679328
160MP0001661_extended_life_span0.11303932

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.30893437
2Abnormal respiratory motile cilium morphology (HP:0005938)9.30893437
3Abnormal respiratory motile cilium physiology (HP:0012261)9.23487257
4Severe visual impairment (HP:0001141)8.65442822
5Infertility (HP:0000789)7.33452215
6Chronic bronchitis (HP:0004469)7.23660491
7Rhinitis (HP:0012384)7.21422881
8Abnormal ciliary motility (HP:0012262)7.20633387
9Nasal polyposis (HP:0100582)6.41737018
10Male infertility (HP:0003251)5.41830072
11Abnormality of the nasal mucosa (HP:0000433)5.28766717
12Bony spicule pigmentary retinopathy (HP:0007737)5.19179237
13Attenuation of retinal blood vessels (HP:0007843)5.12347328
14Hyperkalemia (HP:0002153)4.86147478
15Resting tremor (HP:0002322)4.68009726
16Bronchitis (HP:0012387)4.56822607
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.43620968
18Chronic hepatic failure (HP:0100626)4.42195120
19Bronchiectasis (HP:0002110)4.29916779
20Abnormal rod and cone electroretinograms (HP:0008323)4.23571349
21Facial shape deformation (HP:0011334)4.15989668
22Potter facies (HP:0002009)4.15989668
23Abnormality of macular pigmentation (HP:0008002)4.13589789
24Nephronophthisis (HP:0000090)3.96718252
25Abnormal spermatogenesis (HP:0008669)3.90594764
26Hypoplastic ischia (HP:0003175)3.69948178
27Cone-rod dystrophy (HP:0000548)3.62756557
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.42513478
29Enlarged epiphyses (HP:0010580)3.40392429
30Unilateral renal agenesis (HP:0000122)3.35438889
31Hypoplasia of the thymus (HP:0000778)3.34995081
32Abnormality of the ischium (HP:0003174)3.29949920
33Recurrent otitis media (HP:0000403)3.25788809
34Recurrent sinusitis (HP:0011108)3.20003701
35Progressive sensorineural hearing impairment (HP:0000408)3.10471323
36Hypoalphalipoproteinemia (HP:0003233)3.04764737
37Postural instability (HP:0002172)3.02963454
38Abnormality of the aortic arch (HP:0012303)2.97456462
39Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.97358627
40Abnormality of the renal medulla (HP:0100957)2.95997923
41Impulsivity (HP:0100710)2.80682440
42Recurrent bronchitis (HP:0002837)2.78930684
43Generalized aminoaciduria (HP:0002909)2.78680281
44Abnormal gallbladder physiology (HP:0012438)2.78409100
45Cholecystitis (HP:0001082)2.78409100
46Abnormality of potassium homeostasis (HP:0011042)2.73572767
47Tubulointerstitial nephritis (HP:0001970)2.68163881
48Tubular atrophy (HP:0000092)2.57860087
49Renovascular hypertension (HP:0100817)2.52563324
50Menstrual irregularities (HP:0000858)2.50913059
51Abnormality of the parathyroid morphology (HP:0011766)2.50325563
52Insulin-resistant diabetes mellitus (HP:0000831)2.47433695
53Amelogenesis imperfecta (HP:0000705)2.44372528
54Progressive cerebellar ataxia (HP:0002073)2.42627082
55Abnormality of midbrain morphology (HP:0002418)2.41714533
56Molar tooth sign on MRI (HP:0002419)2.41714533
57Tubulointerstitial abnormality (HP:0001969)2.40243101
58Abnormality of the costochondral junction (HP:0000919)2.39432917
59Dyschromatopsia (HP:0007641)2.38239470
60Portal hypertension (HP:0001409)2.34943665
61Gonadotropin excess (HP:0000837)2.28626606
62Flattened epiphyses (HP:0003071)2.27809022
63Choroideremia (HP:0001139)2.26504012
64Azoospermia (HP:0000027)2.26262850
65Ventricular tachycardia (HP:0004756)2.21573449
66Tetany (HP:0001281)2.18930190
67Epiphyseal dysplasia (HP:0002656)2.17572209
68Abnormality of dental color (HP:0011073)2.16944437
69Abnormality of the hepatic vasculature (HP:0006707)2.13889364
70Medial flaring of the eyebrow (HP:0010747)2.09374235
71Decreased central vision (HP:0007663)2.08670821
72Osteomalacia (HP:0002749)2.07917638
73Spastic tetraparesis (HP:0001285)2.07364333
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05775323
75Myokymia (HP:0002411)2.05479288
76Hyponatremia (HP:0002902)2.05432392
77Tubulointerstitial fibrosis (HP:0005576)2.03421627
78Widely patent fontanelles and sutures (HP:0004492)2.03420736
79Abnormal ventriculo-arterial connection (HP:0011563)2.01247231
80Transposition of the great arteries (HP:0001669)2.01247231
81Abnormal connection of the cardiac segments (HP:0011545)2.01247231
82Hyperthyroidism (HP:0000836)2.00172127
83Dynein arm defect of respiratory motile cilia (HP:0012255)13.6505903
84Absent/shortened dynein arms (HP:0200106)13.6505903
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.6709317
86Abnormality of the epiphysis of the femoral head (HP:0010574)1.98423367
87Hemorrhage of the eye (HP:0011885)1.97465130
88Progressive hearing impairment (HP:0001730)1.95173615
89Increased purine levels (HP:0004368)1.95056900
90Hyperuricemia (HP:0002149)1.95056900
91Recurrent pneumonia (HP:0006532)1.94529174
92Peripheral hypomyelination (HP:0007182)1.92547363
93Neurofibrillary tangles (HP:0002185)1.89629353
94Hypoparathyroidism (HP:0000829)1.88965995
95Congenital malformation of the right heart (HP:0011723)1.88880129
96Double outlet right ventricle (HP:0001719)1.88880129
97Abnormality of the pubic bones (HP:0003172)1.87391880
98Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.84920776
99Abnormality of femoral epiphyses (HP:0006499)1.84920776
100Hypophosphatemic rickets (HP:0004912)1.84103279
101Flat capital femoral epiphysis (HP:0003370)1.82620943
102Optic nerve hypoplasia (HP:0000609)1.81098302
103Amblyopia (HP:0000646)1.80616292
104Atelectasis (HP:0100750)1.80367877
105Spastic paraparesis (HP:0002313)1.80264659
106Abnormal drinking behavior (HP:0030082)1.76641837
107Polydipsia (HP:0001959)1.76641837
108Decreased electroretinogram (ERG) amplitude (HP:0000654)1.76148889
109Heterotopia (HP:0002282)1.73122636
110Abnormal biliary tract physiology (HP:0012439)1.71192704
111Bile duct proliferation (HP:0001408)1.71192704
112Stage 5 chronic kidney disease (HP:0003774)1.67178623
113Abnormality of renal excretion (HP:0011036)1.62699962
114Postaxial foot polydactyly (HP:0001830)1.61591249
115Exercise-induced myalgia (HP:0003738)1.57457105
116Cerebral inclusion bodies (HP:0100314)1.56940749
117Asymmetric septal hypertrophy (HP:0001670)1.56027178
118Bell-shaped thorax (HP:0001591)1.55645486
119Congenital hepatic fibrosis (HP:0002612)1.53880085
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.52933141
121Abnormality of the renal cortex (HP:0011035)1.51421346
122Bundle branch block (HP:0011710)1.48365294
123Myoglobinuria (HP:0002913)1.48017271
124Short ribs (HP:0000773)1.47612715
125Hypercholesterolemia (HP:0003124)1.44053854
126Oculomotor apraxia (HP:0000657)1.43196653
127Aplasia/Hypoplasia of the lens (HP:0008063)1.42943534
128Abnormal urine output (HP:0012590)1.42725415
129Easy fatigability (HP:0003388)1.41634734
130Sensory axonal neuropathy (HP:0003390)1.38077440
131Abnormality of dentin (HP:0010299)1.37952306
132Deformed sella turcica (HP:0002681)1.33176835
133Loss of speech (HP:0002371)1.32588836
134Constricted visual fields (HP:0001133)1.32578759
135Hemiparesis (HP:0001269)1.32406367
136Neoplasm of the heart (HP:0100544)1.32152778
137Rhabdomyolysis (HP:0003201)1.31289356
138Abnormality of the dental root (HP:0006486)1.31006080
139Taurodontia (HP:0000679)1.31006080
140Abnormality of permanent molar morphology (HP:0011071)1.31006080
141Renal dysplasia (HP:0000110)1.30911299
142Fatigable weakness (HP:0003473)1.29608714
143Abnormality of the neuromuscular junction (HP:0003398)1.29608714
144Postaxial hand polydactyly (HP:0001162)1.27844302
145Cystic liver disease (HP:0006706)1.25882442
146Fibular hypoplasia (HP:0003038)1.25007482
147Abnormality of the dental pulp (HP:0006479)1.23644004
148Broad distal phalanx of finger (HP:0009836)1.22762970
149Facial cleft (HP:0002006)1.21779136
150Exercise-induced muscle cramps (HP:0003710)1.21326502
151Abnormality of the lower motor neuron (HP:0002366)1.20035575
152Truncal obesity (HP:0001956)1.19790957
153Abnormality of molar (HP:0011077)1.19515322
154Abnormality of molar morphology (HP:0011070)1.19515322
155Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.19494001
156Absent epiphyses (HP:0010577)1.19494001
157Cerebellar dysplasia (HP:0007033)1.17769724
158Generalized muscle weakness (HP:0003324)1.15336225
159Short femoral neck (HP:0100864)1.13730893
160Polyuria (HP:0000103)1.13565748
161Amyotrophic lateral sclerosis (HP:0007354)1.12489429
162Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.12085289
163Nephropathy (HP:0000112)1.11469414
164Polymicrogyria (HP:0002126)1.11308904

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK37.61471140
2PDK47.61471140
3TESK16.97018950
4PRKD35.68970391
5ICK5.06001692
6DDR24.94024827
7PDK24.91539735
8MAP4K23.55493316
9INSRR2.86967396
10PLK22.71386328
11BRD42.67954229
12PTK2B2.25988577
13WNK42.15624892
14STK392.04546538
15STK381.94974437
16MST1R1.94814748
17DYRK1B1.85756961
18PNCK1.84169089
19NEK21.49959165
20CDK121.32202779
21PDK11.30443704
22CDK71.29921118
23PIK3CG1.29673294
24KSR21.16255225
25MAP3K91.11615726
26AKT31.00219101
27MAPK150.94554845
28DYRK30.93588148
29TYRO30.91482104
30PDPK10.90503247
31RIPK40.88223021
32SIK20.87670404
33CAMK1D0.83317960
34LATS20.83162942
35WNK10.82381373
36UHMK10.81409222
37MAP3K110.77896750
38EEF2K0.73819667
39IRAK10.73086724
40MAP3K20.72101178
41RPS6KA20.71291873
42MAP2K20.70187564
43TESK20.66995382
44PASK0.65931376
45MAP3K80.64361060
46CCNB10.63275180
47ROCK10.61942785
48MAP2K60.58610753
49PINK10.58406052
50PRKAA20.58001649
51TTK0.57127385
52CAMK1G0.56200277
53STK30.54592411
54CAMK10.53973956
55CHEK20.52430799
56SGK2230.50542572
57SGK4940.50542572
58NTRK20.49416798
59LATS10.46555704
60MUSK0.45271957
61PAK10.45141113
62CDK30.44864331
63MAP3K100.42359371
64PRKCG0.41742370
65IRAK20.41656117
66MAPK10.41645765
67BMPR1B0.40151847
68RPS6KL10.37610357
69RPS6KC10.37610357
70LMTK20.36900577
71STK38L0.36521159
72PAK20.35449352
73RPS6KA60.34759073
74ARAF0.34171127
75CHEK10.33910808
76CAMK40.33893145
77PAK40.33801081
78SGK10.32818428
79MAPKAPK50.30587044
80MARK20.29884555
81MET0.29230497
82MARK10.28678669
83CAMKK10.26561765
84MAPK140.26229724
85MTOR0.25561558
86MAPK100.24279606
87NTRK30.23955644
88PRKCZ0.23417305
89ATM0.22783871
90MINK10.21114178
91CDK150.20375055
92FER0.18708424
93PRKCQ0.17683656
94PRKAA10.17608495
95CDK180.17536919
96AKT10.16713255
97CDK11A0.16229484
98MAPK110.15978220
99ATR0.15933001
100NEK60.15445686
101OXSR10.15205893
102ACVR1B0.14905186
103MAP3K40.12780283
104PRKG20.12584155
105RPS6KB10.12391178
106CDK140.11989268
107TIE10.10538410
108BRSK20.10291035
109TNIK0.09918919
110RPS6KA10.09614336
111BRSK10.09114003
112STK100.08378000
113BRAF0.08062437
114IKBKB0.07965491
115GSK3B0.07150482
116MAPK90.07067343
117CSF1R0.06578293
118CDK60.06556721
119CSNK2A10.06248917
120BLK0.06179354
121CLK10.06176156
122PRKCD0.05743767
123WEE10.05731349
124PLK10.05637640
125SGK20.05398065
126JAK30.03801700
127STK110.03687446
128CAMK2A0.03651455
129PIM10.03288922
130EPHB10.02956816
131PRKACG0.02493964
132PRKCB0.02336476
133MAPK80.02316685
134PRKG10.02137514
135CSNK1D0.01892428
136MARK30.01848046
137PRKCA0.01678117
138TRIB30.01587530
139CDK10.01008810
140CDK20.00874079
141PAK60.00661388
142CDC70.00383635
143MAP3K10.00347996
144PLK40.00297285
145PKN10.00151614
146CSK-0.0432792
147SRC-0.0428645
148PRKACB-0.0378821
149PRKACA-0.0348247
150PDGFRB-0.0338171
151CDK4-0.0295577
152RPS6KA3-0.0238550
153AURKA-0.0209351
154EGFR-0.0143944
155CSNK2A2-0.0033201

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.34158450
2Fatty acid biosynthesis_Homo sapiens_hsa000615.09994315
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.58096679
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.26519698
5Olfactory transduction_Homo sapiens_hsa047403.18315459
6Pyruvate metabolism_Homo sapiens_hsa006203.17111392
7Linoleic acid metabolism_Homo sapiens_hsa005913.14193892
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.09643514
9Vitamin B6 metabolism_Homo sapiens_hsa007503.06182413
10Butanoate metabolism_Homo sapiens_hsa006502.70248415
11Carbohydrate digestion and absorption_Homo sapiens_hsa049732.54797392
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49663332
13Glucagon signaling pathway_Homo sapiens_hsa049222.47695077
14Propanoate metabolism_Homo sapiens_hsa006402.39816729
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.14826099
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.06876530
17PPAR signaling pathway_Homo sapiens_hsa033201.97037490
18Glycerolipid metabolism_Homo sapiens_hsa005611.93219644
19Basal transcription factors_Homo sapiens_hsa030221.87145999
20Selenocompound metabolism_Homo sapiens_hsa004501.78138307
21Glycerophospholipid metabolism_Homo sapiens_hsa005641.76576933
22Fructose and mannose metabolism_Homo sapiens_hsa000511.72249584
23Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.69386103
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65451424
25Fatty acid degradation_Homo sapiens_hsa000711.64451258
26Mineral absorption_Homo sapiens_hsa049781.63493116
27Type I diabetes mellitus_Homo sapiens_hsa049401.63037366
28Fat digestion and absorption_Homo sapiens_hsa049751.62707480
29Fatty acid metabolism_Homo sapiens_hsa012121.62478720
30Allograft rejection_Homo sapiens_hsa053301.56511099
31Autoimmune thyroid disease_Homo sapiens_hsa053201.51926455
32Ether lipid metabolism_Homo sapiens_hsa005651.47087147
33Amphetamine addiction_Homo sapiens_hsa050311.46486728
34Graft-versus-host disease_Homo sapiens_hsa053321.42091111
35Oocyte meiosis_Homo sapiens_hsa041141.40538374
36Phenylalanine metabolism_Homo sapiens_hsa003601.39417883
37Carbon metabolism_Homo sapiens_hsa012001.34279768
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31816725
39Dorso-ventral axis formation_Homo sapiens_hsa043201.30419977
40Cardiac muscle contraction_Homo sapiens_hsa042601.30228351
41Pentose phosphate pathway_Homo sapiens_hsa000301.29570134
42Arginine and proline metabolism_Homo sapiens_hsa003301.19641470
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.17315964
44Viral myocarditis_Homo sapiens_hsa054161.11672939
45Antigen processing and presentation_Homo sapiens_hsa046121.08199373
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.07922232
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.06783544
48Hedgehog signaling pathway_Homo sapiens_hsa043401.03440177
49Renin secretion_Homo sapiens_hsa049241.03306904
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00597405
51Phototransduction_Homo sapiens_hsa047440.98694706
52Glutathione metabolism_Homo sapiens_hsa004800.98451292
53Collecting duct acid secretion_Homo sapiens_hsa049660.96698014
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.93087254
55Insulin secretion_Homo sapiens_hsa049110.91632830
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91278312
57Purine metabolism_Homo sapiens_hsa002300.90872872
58Arachidonic acid metabolism_Homo sapiens_hsa005900.87745173
59Morphine addiction_Homo sapiens_hsa050320.87469416
60Chemical carcinogenesis_Homo sapiens_hsa052040.86045058
61Bile secretion_Homo sapiens_hsa049760.85977472
62Biosynthesis of amino acids_Homo sapiens_hsa012300.84899295
63Thyroid hormone synthesis_Homo sapiens_hsa049180.82562841
64Arginine biosynthesis_Homo sapiens_hsa002200.82033520
65mRNA surveillance pathway_Homo sapiens_hsa030150.79197846
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78172753
67Estrogen signaling pathway_Homo sapiens_hsa049150.76236580
68Fanconi anemia pathway_Homo sapiens_hsa034600.75376657
69Long-term potentiation_Homo sapiens_hsa047200.73057167
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72072065
71Huntingtons disease_Homo sapiens_hsa050160.70485892
72Influenza A_Homo sapiens_hsa051640.67578498
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63940222
74Legionellosis_Homo sapiens_hsa051340.63409258
75Salivary secretion_Homo sapiens_hsa049700.62970642
76Pancreatic secretion_Homo sapiens_hsa049720.62552069
77Tyrosine metabolism_Homo sapiens_hsa003500.60060878
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.59637661
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59323373
80RNA transport_Homo sapiens_hsa030130.56294958
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56253922
82Protein digestion and absorption_Homo sapiens_hsa049740.53607572
83Nicotine addiction_Homo sapiens_hsa050330.52867115
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52828494
85Tight junction_Homo sapiens_hsa045300.52231780
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.51417095
87ABC transporters_Homo sapiens_hsa020100.50766582
88Renin-angiotensin system_Homo sapiens_hsa046140.50498207
89Gastric acid secretion_Homo sapiens_hsa049710.50174201
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49284853
91Synaptic vesicle cycle_Homo sapiens_hsa047210.49027560
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48962729
93MAPK signaling pathway_Homo sapiens_hsa040100.47691799
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.47366459
95Acute myeloid leukemia_Homo sapiens_hsa052210.45706093
96Endocytosis_Homo sapiens_hsa041440.45179163
97Calcium signaling pathway_Homo sapiens_hsa040200.45176864
98Retinol metabolism_Homo sapiens_hsa008300.44130745
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.43696578
100Sulfur metabolism_Homo sapiens_hsa009200.42810086
101AMPK signaling pathway_Homo sapiens_hsa041520.41908328
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40634274
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40472883
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39414470
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38412860
106Systemic lupus erythematosus_Homo sapiens_hsa053220.37416651
107VEGF signaling pathway_Homo sapiens_hsa043700.35421581
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34489072
109Metabolic pathways_Homo sapiens_hsa011000.33915963
110Viral carcinogenesis_Homo sapiens_hsa052030.33631622
111Cholinergic synapse_Homo sapiens_hsa047250.33329033
112Serotonergic synapse_Homo sapiens_hsa047260.33139078
113cAMP signaling pathway_Homo sapiens_hsa040240.31630095
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28087682
115Inositol phosphate metabolism_Homo sapiens_hsa005620.27673670
116GABAergic synapse_Homo sapiens_hsa047270.26236982
117Circadian entrainment_Homo sapiens_hsa047130.24829550
118Taste transduction_Homo sapiens_hsa047420.24355369
119Cocaine addiction_Homo sapiens_hsa050300.23349502
120Pyrimidine metabolism_Homo sapiens_hsa002400.23107476
121Oxytocin signaling pathway_Homo sapiens_hsa049210.21867641
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.21707183
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.21417901
124Alcoholism_Homo sapiens_hsa050340.20739742
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20506198
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19395043
127Prolactin signaling pathway_Homo sapiens_hsa049170.18182695
128Nitrogen metabolism_Homo sapiens_hsa009100.16566347
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.14522479
130Adherens junction_Homo sapiens_hsa045200.13789719
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.13436393
132HIF-1 signaling pathway_Homo sapiens_hsa040660.12244042
133Herpes simplex infection_Homo sapiens_hsa051680.11599800
134Basal cell carcinoma_Homo sapiens_hsa052170.09945610
135B cell receptor signaling pathway_Homo sapiens_hsa046620.09856454
136Salmonella infection_Homo sapiens_hsa051320.09122811
137Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08050556
138Wnt signaling pathway_Homo sapiens_hsa043100.07467765
139Type II diabetes mellitus_Homo sapiens_hsa049300.05974248
140Glutamatergic synapse_Homo sapiens_hsa047240.05022715

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