LEAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.36865624
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.50998084
3L-phenylalanine catabolic process (GO:0006559)7.50998084
4L-phenylalanine metabolic process (GO:0006558)7.21541975
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.21541975
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.74050161
7aromatic amino acid family catabolic process (GO:0009074)6.72995778
8epoxygenase P450 pathway (GO:0019373)6.57164797
9tryptophan catabolic process (GO:0006569)6.05627210
10indole-containing compound catabolic process (GO:0042436)6.05627210
11indolalkylamine catabolic process (GO:0046218)6.05627210
12omega-hydroxylase P450 pathway (GO:0097267)6.00039000
13kynurenine metabolic process (GO:0070189)5.92121074
14glyoxylate metabolic process (GO:0046487)5.86909456
15bile acid biosynthetic process (GO:0006699)5.86728251
16high-density lipoprotein particle remodeling (GO:0034375)5.85468590
17tryptophan metabolic process (GO:0006568)5.70998731
18urea metabolic process (GO:0019627)5.67366947
19urea cycle (GO:0000050)5.67366947
20negative regulation of fibrinolysis (GO:0051918)5.63804606
21alpha-linolenic acid metabolic process (GO:0036109)5.51946693
22oxidative demethylation (GO:0070989)5.49996620
23drug metabolic process (GO:0017144)5.46897176
24regulation of fibrinolysis (GO:0051917)5.43157621
25cysteine metabolic process (GO:0006534)5.36537914
26sulfur amino acid catabolic process (GO:0000098)5.34528857
27peptidyl-glutamic acid carboxylation (GO:0017187)5.31461101
28protein carboxylation (GO:0018214)5.31461101
29nitrogen cycle metabolic process (GO:0071941)5.21785056
30regulation of protein activation cascade (GO:2000257)5.19581887
31regulation of cholesterol esterification (GO:0010872)5.19413135
32regulation of triglyceride catabolic process (GO:0010896)5.19045517
33complement activation, alternative pathway (GO:0006957)5.17651249
34reverse cholesterol transport (GO:0043691)5.16152521
35serine family amino acid catabolic process (GO:0009071)5.07372220
36bile acid metabolic process (GO:0008206)5.00870248
37plasma lipoprotein particle remodeling (GO:0034369)5.00261954
38protein-lipid complex remodeling (GO:0034368)5.00261954
39macromolecular complex remodeling (GO:0034367)5.00261954
40intestinal cholesterol absorption (GO:0030299)4.99122162
41phospholipid efflux (GO:0033700)4.95128237
42aromatic amino acid family metabolic process (GO:0009072)4.90511316
43fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87334708
44regulation of complement activation (GO:0030449)4.83019018
45acylglycerol homeostasis (GO:0055090)4.75421873
46triglyceride homeostasis (GO:0070328)4.75421873
47negative regulation of sterol transport (GO:0032372)4.74421531
48negative regulation of cholesterol transport (GO:0032375)4.74421531
49tyrosine metabolic process (GO:0006570)4.74305959
50S-adenosylmethionine metabolic process (GO:0046500)4.72070357
51homocysteine metabolic process (GO:0050667)4.67717418
52phenylpropanoid metabolic process (GO:0009698)4.67680693
53plasma lipoprotein particle clearance (GO:0034381)4.57031615
54alpha-amino acid catabolic process (GO:1901606)4.56665807
55cellular ketone body metabolic process (GO:0046950)4.55730970
56amino-acid betaine metabolic process (GO:0006577)4.50868813
57lysine catabolic process (GO:0006554)4.48452273
58lysine metabolic process (GO:0006553)4.48452273
59regulation of plasminogen activation (GO:0010755)4.45540156
60cholesterol efflux (GO:0033344)4.44426717
61glycine metabolic process (GO:0006544)4.43367225
62coenzyme catabolic process (GO:0009109)4.36274304
63fat-soluble vitamin biosynthetic process (GO:0042362)4.36212215
64bile acid and bile salt transport (GO:0015721)4.34291652
65alkaloid metabolic process (GO:0009820)4.30084899
66indolalkylamine metabolic process (GO:0006586)4.30076992
67plasma lipoprotein particle assembly (GO:0034377)4.29373198
68imidazole-containing compound metabolic process (GO:0052803)4.29119653
69cellular glucuronidation (GO:0052695)4.23688265
70cellular amino acid catabolic process (GO:0009063)4.20842451
71cellular biogenic amine catabolic process (GO:0042402)4.20745225
72amine catabolic process (GO:0009310)4.20745225
73glutamate metabolic process (GO:0006536)4.19845880
74regulation of lipoprotein particle clearance (GO:0010984)4.17504191
75serine family amino acid metabolic process (GO:0009069)4.16409990
76positive regulation of triglyceride lipase activity (GO:0061365)4.14975053
77positive regulation of lipoprotein lipase activity (GO:0051006)4.14975053
78heme transport (GO:0015886)4.14838144
79serine family amino acid biosynthetic process (GO:0009070)4.08982227
80aldehyde catabolic process (GO:0046185)4.08726879
81negative regulation of blood coagulation (GO:0030195)4.08698410
82negative regulation of hemostasis (GO:1900047)4.08698410
83benzene-containing compound metabolic process (GO:0042537)4.06775896
84low-density lipoprotein particle remodeling (GO:0034374)4.06360426
85arginine metabolic process (GO:0006525)4.05464538
86cellular modified amino acid catabolic process (GO:0042219)4.03213142
87dicarboxylic acid biosynthetic process (GO:0043650)4.02531858
88ethanol oxidation (GO:0006069)4.01742915
89fibrinolysis (GO:0042730)3.98031367
90very-low-density lipoprotein particle assembly (GO:0034379)3.96302791
91ketone body metabolic process (GO:1902224)3.94585101
92drug catabolic process (GO:0042737)3.92694702
93positive regulation of lipid catabolic process (GO:0050996)3.88286336
94ethanol metabolic process (GO:0006067)3.86908058
95protein-lipid complex assembly (GO:0065005)3.85441624
96blood coagulation, intrinsic pathway (GO:0007597)3.84947066
97cholesterol homeostasis (GO:0042632)3.84385648
98plasma lipoprotein particle organization (GO:0071827)3.82675280
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.81565375
100negative regulation of lipase activity (GO:0060192)3.81414268
101sterol homeostasis (GO:0055092)3.77924769
102glucuronate metabolic process (GO:0019585)3.76102280
103uronic acid metabolic process (GO:0006063)3.76102280
104cofactor catabolic process (GO:0051187)3.75807847
105phospholipid homeostasis (GO:0055091)3.74961132
106negative regulation of coagulation (GO:0050819)3.71111394
107organic acid catabolic process (GO:0016054)3.69875859
108carboxylic acid catabolic process (GO:0046395)3.69875859
109complement activation, classical pathway (GO:0006958)3.68347166
110protein activation cascade (GO:0072376)3.65472753
111negative regulation of fatty acid biosynthetic process (GO:0045717)3.64586862
112regulation of bile acid biosynthetic process (GO:0070857)3.64225724
113complement activation (GO:0006956)3.63240221
114flavonoid metabolic process (GO:0009812)3.62175024
115negative regulation of wound healing (GO:0061045)3.61599751
116drug transmembrane transport (GO:0006855)3.61471316
117cytolysis (GO:0019835)3.61345458
118short-chain fatty acid metabolic process (GO:0046459)3.61285594
119protein-lipid complex subunit organization (GO:0071825)3.60179393
120lipoprotein metabolic process (GO:0042157)3.59984674
121acetyl-CoA metabolic process (GO:0006084)3.59389732
122sterol transport (GO:0015918)3.53933981
123cholesterol transport (GO:0030301)3.53933981
124negative regulation of protein activation cascade (GO:2000258)3.51543722
125polyketide metabolic process (GO:0030638)3.49911938
126doxorubicin metabolic process (GO:0044598)3.49911938
127daunorubicin metabolic process (GO:0044597)3.49911938
128acute-phase response (GO:0006953)3.48714630
129L-methionine biosynthetic process (GO:0071265)3.48470619
130amino acid salvage (GO:0043102)3.48470619
131L-methionine salvage (GO:0071267)3.48470619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.38082686
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.23499149
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.07832679
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.48281019
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.20630011
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.07475753
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.89435686
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01521197
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.97433421
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22468551
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17831224
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04336598
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9882225
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96311600
15HTT_18923047_ChIP-ChIP_STHdh_Human1.59413967
16FOXA2_19822575_ChIP-Seq_HepG2_Human1.58817936
17POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51621144
18CLOCK_20551151_ChIP-Seq_293T_Human1.48730460
19HNF4A_19822575_ChIP-Seq_HepG2_Human1.43210637
20IGF1R_20145208_ChIP-Seq_DFB_Human1.42649908
21GATA1_22025678_ChIP-Seq_K562_Human1.40330705
22ZNF274_21170338_ChIP-Seq_K562_Hela1.32448176
23VDR_22108803_ChIP-Seq_LS180_Human1.30966442
24CDX2_22108803_ChIP-Seq_LS180_Human1.30490390
25IRF1_19129219_ChIP-ChIP_H3396_Human1.28602952
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27353219
27ER_23166858_ChIP-Seq_MCF-7_Human1.25874576
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21361793
29RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21052606
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19113486
31NFE2_27457419_Chip-Seq_LIVER_Mouse1.17279314
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16036905
33ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15008164
34KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14255731
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08848829
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08768687
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.07897805
38* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06438054
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05724080
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05050876
41SOX2_19829295_ChIP-Seq_ESCs_Human1.04930918
42NANOG_19829295_ChIP-Seq_ESCs_Human1.04930918
43FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04209737
44CBP_20019798_ChIP-Seq_JUKART_Human1.03267148
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03267148
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03169604
47MYC_19829295_ChIP-Seq_ESCs_Human1.02240908
48* TCF4_22108803_ChIP-Seq_LS180_Human1.00538697
49SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00227576
50ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98701678
51ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98268820
52EZH2_27294783_Chip-Seq_NPCs_Mouse0.97875732
53PHF8_20622853_ChIP-Seq_HELA_Human0.95037986
54STAT3_23295773_ChIP-Seq_U87_Human0.95003669
55HNFA_21074721_ChIP-Seq_CACO-2_Human0.93707261
56FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93105606
57* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92850157
58* FOXA1_25329375_ChIP-Seq_VCAP_Human0.92850157
59CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91157587
60ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90436945
61TCF4_23295773_ChIP-Seq_U87_Human0.89807507
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89080506
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88720099
64GATA4_25053715_ChIP-Seq_YYC3_Human0.88576722
65* GATA3_21878914_ChIP-Seq_MCF-7_Human0.86731108
66RAC3_21632823_ChIP-Seq_H3396_Human0.86285857
67EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.85766357
68CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84720889
69FLI1_27457419_Chip-Seq_LIVER_Mouse0.84258396
70GBX2_23144817_ChIP-Seq_PC3_Human0.84167440
71RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84009473
72OCT4_20526341_ChIP-Seq_ESCs_Human0.83536117
73NANOG_20526341_ChIP-Seq_ESCs_Human0.83395754
74TP53_16413492_ChIP-PET_HCT116_Human0.82936202
75ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82872243
76ERA_21632823_ChIP-Seq_H3396_Human0.82803506
77IRF8_22096565_ChIP-ChIP_GC-B_Human0.82500388
78ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.82109930
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82073298
80* CRX_20693478_ChIP-Seq_RETINA_Mouse0.82029106
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81746225
82ETV1_20927104_ChIP-Seq_GIST48_Human0.81279721
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78747921
84GATA3_26560356_Chip-Seq_TH1_Human0.78602576
85SMAD4_21741376_ChIP-Seq_EPCs_Human0.78597025
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78466811
87PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78018663
88SOX2_21211035_ChIP-Seq_LN229_Human0.77410691
89CBX2_22325352_ChIP-Seq_293T-Rex_Human0.76634325
90RARA_24833708_ChIP-Seq_LIVER_Mouse0.76476109
91NFYA_21822215_ChIP-Seq_K562_Human0.76178389
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75997192
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74766522
94OCT4_18555785_Chip-Seq_ESCs_Mouse0.74553945
95TP53_22573176_ChIP-Seq_HFKS_Human0.73835266
96ZNF263_19887448_ChIP-Seq_K562_Human0.73087364
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.72732078
98CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72686724
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70053128
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68196579
101ESR2_21235772_ChIP-Seq_MCF-7_Human0.66952063
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.65733694
103RARB_24833708_ChIP-Seq_LIVER_Mouse0.65593069
104RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65156817
105BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64792145
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64602844
107* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64214867
108NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64168117
109NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64168117
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64012180
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63781175
112CDX2_20551321_ChIP-Seq_CACO-2_Human0.61454698
113NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.59185019
114CEBPB_22108803_ChIP-Seq_LS180_Human0.57824779
115EGR1_19032775_ChIP-ChIP_M12_Human0.57215514
116AR_20517297_ChIP-Seq_VCAP_Human0.56536964
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55091244
118E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.54494325
119LXR_22292898_ChIP-Seq_THP-1_Human0.54031365
120* MYC_19915707_ChIP-ChIP_AK7_Human0.52632359
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.52481739
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51728133
123FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.51591624
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51000236
125FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49960602
126ESET_19884257_ChIP-Seq_ESCs_Mouse0.49562344
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49242980
128CBP_21632823_ChIP-Seq_H3396_Human0.49026738
129STAT1_17558387_ChIP-Seq_HELA_Human0.48514883
130PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46881986
131P53_21459846_ChIP-Seq_SAOS-2_Human0.46744515
132GATA1_19941827_ChIP-Seq_MEL_Mouse0.45927622
133PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44930046
134ESR1_21235772_ChIP-Seq_MCF-7_Human0.44917548
135TAF2_19829295_ChIP-Seq_ESCs_Human0.44751969
136GATA6_25053715_ChIP-Seq_YYC3_Human0.44335076
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42808216
138PPAR_26484153_Chip-Seq_NCI-H1993_Human0.42572319
139FOXO3_23340844_ChIP-Seq_DLD1_Human0.42354532
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42271896
141BCAT_22108803_ChIP-Seq_LS180_Human0.41873747
142GATA1_19941826_ChIP-Seq_K562_Human0.41134803
143GATA2_19941826_ChIP-Seq_K562_Human0.40447232
144CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40426504
145SOX2_20726797_ChIP-Seq_SW620_Human0.38021929
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.37366106
147SPI1_26923725_Chip-Seq_HPCs_Mouse0.37272746
148STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37168642
149SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36191590
150* MYC_27129775_Chip-Seq_CORNEA_Mouse0.35543414
151ESR1_20079471_ChIP-ChIP_T-47D_Human0.35012062
152NCOR_22424771_ChIP-Seq_293T_Human0.34931775
153SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34628399
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.34529269
155* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34277145
156TAF15_26573619_Chip-Seq_HEK293_Human0.33959376
157ERG_20517297_ChIP-Seq_VCAP_Human0.33890784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.32489098
2MP0005360_urolithiasis7.78033780
3MP0005085_abnormal_gallbladder_physiolo6.36192459
4MP0005365_abnormal_bile_salt6.10342068
5MP0008875_abnormal_xenobiotic_pharmacok5.02222568
6MP0003806_abnormal_nucleotide_metabolis4.34349296
7MP0003252_abnormal_bile_duct3.92478817
8MP0010329_abnormal_lipoprotein_level3.66883969
9MP0009840_abnormal_foam_cell3.49766288
10MP0005083_abnormal_biliary_tract2.96526724
11MP0001666_abnormal_nutrient_absorption2.76278107
12MP0003195_calcinosis2.75519600
13MP0005332_abnormal_amino_acid2.72928150
14MP0003191_abnormal_cellular_cholesterol2.34218430
15MP0004019_abnormal_vitamin_homeostasis2.14652815
16MP0000609_abnormal_liver_physiology2.14560743
17MP0002118_abnormal_lipid_homeostasis2.09270054
18MP0002138_abnormal_hepatobiliary_system1.88675797
19MP0003868_abnormal_feces_composition1.87249894
20MP0005319_abnormal_enzyme/_coenzyme1.80912010
21MP0009697_abnormal_copulation1.77641890
22MP0001764_abnormal_homeostasis1.70903807
23MP0005584_abnormal_enzyme/coenzyme_acti1.57285177
24MP0005451_abnormal_body_composition1.46227971
25MP0003011_delayed_dark_adaptation1.37732653
26MP0003656_abnormal_erythrocyte_physiolo1.28247019
27MP0003186_abnormal_redox_activity1.24921450
28MP0009643_abnormal_urine_homeostasis1.23523534
29MP0001986_abnormal_taste_sensitivity1.16133780
30MP0000598_abnormal_liver_morphology1.14833538
31MP0003705_abnormal_hypodermis_morpholog1.13529469
32MP0000604_amyloidosis1.11485199
33MP0005647_abnormal_sex_gland1.08459541
34MP0009764_decreased_sensitivity_to1.04258547
35MP0002254_reproductive_system_inflammat1.00932560
36MP0009763_increased_sensitivity_to0.99704047
37MP0010368_abnormal_lymphatic_system0.97139864
38MP0005636_abnormal_mineral_homeostasis0.93708220
39MP0005551_abnormal_eye_electrophysiolog0.90429381
40MP0008469_abnormal_protein_level0.88491754
41MP0009642_abnormal_blood_homeostasis0.87649099
42MP0004147_increased_porphyrin_level0.86699716
43MP0005408_hypopigmentation0.85211210
44MP0005084_abnormal_gallbladder_morpholo0.82229561
45MP0006036_abnormal_mitochondrial_physio0.81617417
46MP0005376_homeostasis/metabolism_phenot0.81385751
47MP0002876_abnormal_thyroid_physiology0.78886363
48MP0009765_abnormal_xenobiotic_induced0.78175464
49MP0004043_abnormal_pH_regulation0.77110004
50MP0002078_abnormal_glucose_homeostasis0.76898254
51MP0009053_abnormal_anal_canal0.67917831
52MP0002971_abnormal_brown_adipose0.67868133
53MP0005220_abnormal_exocrine_pancreas0.67627971
54MP0005334_abnormal_fat_pad0.67456918
55MP0005266_abnormal_metabolism0.66476438
56MP0005535_abnormal_body_temperature0.66449072
57MP0003690_abnormal_glial_cell0.62993700
58MP0004142_abnormal_muscle_tone0.60695284
59MP0004130_abnormal_muscle_cell0.60271729
60MP0005670_abnormal_white_adipose0.60068974
61MP0003879_abnormal_hair_cell0.59667329
62MP0000639_abnormal_adrenal_gland0.59533484
63MP0003646_muscle_fatigue0.59012696
64MP0003329_amyloid_beta_deposits0.58995676
65MP0005448_abnormal_energy_balance0.58954690
66MP0002160_abnormal_reproductive_system0.58553564
67MP0001756_abnormal_urination0.57985938
68MP0002822_catalepsy0.57030175
69MP0001661_extended_life_span0.56262387
70MP0003890_abnormal_embryonic-extraembry0.55168622
71MP0006035_abnormal_mitochondrial_morpho0.53211940
72MP0003136_yellow_coat_color0.52531941
73MP0005464_abnormal_platelet_physiology0.52159280
74MP0005646_abnormal_pituitary_gland0.51443627
75MP0003718_maternal_effect0.50937006
76MP0005377_hearing/vestibular/ear_phenot0.49812576
77MP0003878_abnormal_ear_physiology0.49812576
78MP0005645_abnormal_hypothalamus_physiol0.49715512
79MP0001324_abnormal_eye_pigmentation0.48962378
80MP0005395_other_phenotype0.48175369
81MP0003183_abnormal_peptide_metabolism0.47859796
82MP0001915_intracranial_hemorrhage0.46502259
83MP0003638_abnormal_response/metabolism_0.45364109
84MP0002136_abnormal_kidney_physiology0.45148257
85MP0005389_reproductive_system_phenotype0.44556030
86MP0008873_increased_physiological_sensi0.44432784
87MP0008874_decreased_physiological_sensi0.44022435
88MP0004782_abnormal_surfactant_physiolog0.43833698
89MP0001485_abnormal_pinna_reflex0.43415930
90MP0005166_decreased_susceptibility_to0.42459274
91MP0008872_abnormal_physiological_respon0.42436041
92MP0003436_decreased_susceptibility_to0.41710504
93MP0002837_dystrophic_cardiac_calcinosis0.41500243
94MP0003075_altered_response_to0.41246916
95MP0003953_abnormal_hormone_level0.41178615
96MP0002928_abnormal_bile_duct0.40707221
97MP0003724_increased_susceptibility_to0.40334284
98MP0004381_abnormal_hair_follicle0.40292429
99MP0005187_abnormal_penis_morphology0.39606046
100MP0009780_abnormal_chondrocyte_physiolo0.38803777
101MP0001919_abnormal_reproductive_system0.38112879
102MP0002909_abnormal_adrenal_gland0.37838259
103MP0005248_abnormal_Harderian_gland0.37316123
104MP0002796_impaired_skin_barrier0.37094890
105MP0000372_irregular_coat_pigmentation0.37088998
106MP0006082_CNS_inflammation0.36221471
107MP0002638_abnormal_pupillary_reflex0.34492656
108MP0008877_abnormal_DNA_methylation0.34289171
109MP0000249_abnormal_blood_vessel0.33468401
110MP0002132_abnormal_respiratory_system0.33349534
111MP0004924_abnormal_behavior0.32786788
112MP0005386_behavior/neurological_phenoty0.32786788
113MP0009115_abnormal_fat_cell0.32550653
114MP0005409_darkened_coat_color0.32510289
115MP0000230_abnormal_systemic_arterial0.32392876
116MP0005666_abnormal_adipose_tissue0.32340162
117MP0000579_abnormal_nail_morphology0.32193375
118MP0005410_abnormal_fertilization0.32053169
119MP0004883_abnormal_blood_vessel0.31785408
120MP0000371_diluted_coat_color0.31696290
121MP0009672_abnormal_birth_weight0.31423716
122MP0001929_abnormal_gametogenesis0.30719667
123MP0001243_abnormal_dermal_layer0.30505682
124MP0003632_abnormal_nervous_system0.30437760
125MP0000427_abnormal_hair_cycle0.30399509
126MP0001845_abnormal_inflammatory_respons0.29732401
127MP0002282_abnormal_trachea_morphology0.29358499
128MP0009384_cardiac_valve_regurgitation0.28163139
129MP0001881_abnormal_mammary_gland0.27898850
130MP0002970_abnormal_white_adipose0.27181221
131MP0001944_abnormal_pancreas_morphology0.26283518
132MP0003699_abnormal_female_reproductive0.26102593
133MP0002168_other_aberrant_phenotype0.25935148
134MP0005164_abnormal_response_to0.24879899
135MP0001853_heart_inflammation0.23983833
136MP0004264_abnormal_extraembryonic_tissu0.22828362
137MP0005167_abnormal_blood-brain_barrier0.22570920

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.39301930
2Deep venous thrombosis (HP:0002625)7.35578748
3Intrahepatic cholestasis (HP:0001406)7.24566061
4Hypobetalipoproteinemia (HP:0003563)6.74002891
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.58469384
6Prolonged partial thromboplastin time (HP:0003645)6.53696589
7Xanthomatosis (HP:0000991)6.32070340
8Hyperlipoproteinemia (HP:0010980)5.61866121
9Complement deficiency (HP:0004431)5.18409014
10Hypolipoproteinemia (HP:0010981)4.96887081
11Joint hemorrhage (HP:0005261)4.81425177
12Hyperammonemia (HP:0001987)4.60879095
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.50712443
14Abnormality of the common coagulation pathway (HP:0010990)4.45861362
15Epidermoid cyst (HP:0200040)4.42095641
16Hyperglycinemia (HP:0002154)4.39049110
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.26576151
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.23984277
19Hypoalphalipoproteinemia (HP:0003233)4.23073455
20Ketosis (HP:0001946)4.20863529
21Fat malabsorption (HP:0002630)4.19133587
22Abnormality of methionine metabolism (HP:0010901)4.18377781
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11984543
24Hyperglycinuria (HP:0003108)4.00400854
25Hypoglycemic coma (HP:0001325)3.99220092
26Abnormality of serine family amino acid metabolism (HP:0010894)3.94621048
27Abnormality of glycine metabolism (HP:0010895)3.94621048
28Abnormality of the intrinsic pathway (HP:0010989)3.80398194
29Abnormality of complement system (HP:0005339)3.79777237
30Abnormality of pyrimidine metabolism (HP:0004353)3.76937121
31Conjugated hyperbilirubinemia (HP:0002908)3.66170262
32Hypercholesterolemia (HP:0003124)3.56227119
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.40497053
34Abnormality of fatty-acid metabolism (HP:0004359)3.39580656
35Hyperbilirubinemia (HP:0002904)3.33394731
36Steatorrhea (HP:0002570)3.11062971
37Spontaneous abortion (HP:0005268)3.08741920
38Abnormality of serum amino acid levels (HP:0003112)3.05036603
39Delayed CNS myelination (HP:0002188)3.03921912
40Abnormality of nucleobase metabolism (HP:0010932)3.03093464
41Ketoacidosis (HP:0001993)3.02889151
42Hypochromic microcytic anemia (HP:0004840)2.98035178
43Hepatocellular carcinoma (HP:0001402)2.94810805
44Myocardial infarction (HP:0001658)2.86663920
45Metabolic acidosis (HP:0001942)2.83110945
46Osteomalacia (HP:0002749)2.74000656
47Acanthocytosis (HP:0001927)2.71234987
48Skin nodule (HP:0200036)2.71010117
49Systemic lupus erythematosus (HP:0002725)2.67694083
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.67157407
51Dicarboxylic aciduria (HP:0003215)2.67157407
52Abnormality of purine metabolism (HP:0004352)2.66171636
53Nephritis (HP:0000123)2.61309824
54Lethargy (HP:0001254)2.61033398
55Hyperphosphaturia (HP:0003109)2.59285767
56Vascular calcification (HP:0004934)2.54391788
57Hypoglycemic seizures (HP:0002173)2.52617294
58Malnutrition (HP:0004395)2.47392659
59Abnormal gallbladder morphology (HP:0012437)2.44187348
60Spastic diplegia (HP:0001264)2.41027337
61Cerebral edema (HP:0002181)2.40747225
62Cholelithiasis (HP:0001081)2.38912252
63Amyloidosis (HP:0011034)2.38015352
64Gout (HP:0001997)2.35240925
65Mitral stenosis (HP:0001718)2.33904949
66Glomerulonephritis (HP:0000099)2.32834292
67Irritability (HP:0000737)2.32736518
68Abnormal gallbladder physiology (HP:0012438)2.32350995
69Cholecystitis (HP:0001082)2.32350995
70Fair hair (HP:0002286)2.32097154
71Neonatal onset (HP:0003623)2.30116996
72Recurrent gram-negative bacterial infections (HP:0005420)2.30018564
73Abnormal urine phosphate concentration (HP:0012599)2.25727682
74Cardiovascular calcification (HP:0011915)2.25586613
75Gingival bleeding (HP:0000225)2.21682429
76Pancreatitis (HP:0001733)2.18197616
77Sensorimotor neuropathy (HP:0007141)2.16209370
78Menorrhagia (HP:0000132)2.15226012
79Esophageal varix (HP:0002040)2.14548165
80Generalized aminoaciduria (HP:0002909)2.12361993
81Vomiting (HP:0002013)2.09416801
82Brushfield spots (HP:0001088)2.09049806
83Poikilocytosis (HP:0004447)2.08175797
84Late onset (HP:0003584)2.08107231
85Thrombophlebitis (HP:0004418)2.07706266
86Arthropathy (HP:0003040)2.05896896
87Enlarged kidneys (HP:0000105)2.05268171
88Hyperinsulinemic hypoglycemia (HP:0000825)2.02980162
89Reduced antithrombin III activity (HP:0001976)2.02904450
90Hydroxyprolinuria (HP:0003080)1.99695790
91Abnormality of proline metabolism (HP:0010907)1.99695790
92Opisthotonus (HP:0002179)1.98658172
93Abnormality of the gallbladder (HP:0005264)1.98554407
94Hemorrhage of the eye (HP:0011885)1.96689905
95Abnormal cartilage morphology (HP:0002763)1.95622523
96Abnormality of iron homeostasis (HP:0011031)1.93710443
97Renal cortical cysts (HP:0000803)1.93125553
98Rickets (HP:0002748)1.92746179
99Abnormality of transition element cation homeostasis (HP:0011030)1.91818674
100Chronic hepatic failure (HP:0100626)1.88561148
101Hypophosphatemic rickets (HP:0004912)1.83604097
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82684654
103Abnormality of alanine metabolism (HP:0010916)1.82684654
104Hyperalaninemia (HP:0003348)1.82684654
105Retinal atrophy (HP:0001105)1.82581930
106Pigmentary retinal degeneration (HP:0001146)1.82516113
107Elevated hepatic transaminases (HP:0002910)1.80308717
108Abnormality of vitamin metabolism (HP:0100508)1.79266175
109Alkalosis (HP:0001948)1.78816410
110Increased serum pyruvate (HP:0003542)1.77080675
111Abnormal enzyme/coenzyme activity (HP:0012379)1.76386994
112Proximal tubulopathy (HP:0000114)1.75447989
113Abnormality of urine glucose concentration (HP:0011016)1.74680651
114Glycosuria (HP:0003076)1.74680651
115Bifid scrotum (HP:0000048)1.73945701
116Nausea (HP:0002018)1.73793528
117Abnormal tarsal ossification (HP:0008369)1.73035590
118Pulmonary embolism (HP:0002204)1.70743390
119Megaloblastic anemia (HP:0001889)1.69126329
120Bile duct proliferation (HP:0001408)1.67269545
121Abnormal biliary tract physiology (HP:0012439)1.67269545
122Hypothermia (HP:0002045)1.64569874
123Abnormality of vitamin B metabolism (HP:0004340)1.57233581
124Vaginal fistula (HP:0004320)1.55907661
125Thyroiditis (HP:0100646)1.55745161
126Elevated alkaline phosphatase (HP:0003155)1.54155263
127Joint swelling (HP:0001386)1.52105961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.23016784
2FGFR44.57254644
3ERN14.45583756
4SIK14.44317969
5ACVR1B4.14413200
6MUSK3.08145987
7PDK23.02010926
8TAOK33.00459920
9STK392.98480088
10EIF2AK32.91939283
11INSRR2.83321006
12ERBB42.78776899
13OXSR12.66373751
14MST1R2.36633430
15WNK32.28993960
16PKN22.28772190
17MAP2K42.17509122
18WNK42.12616344
19MAP3K122.11924589
20NLK2.02690628
21FLT31.95106189
22BMPR1B1.88885308
23MAPK111.88781790
24PIK3CG1.82343349
25TYK21.77943643
26DAPK21.76543746
27CASK1.72288019
28FRK1.69224421
29BRSK21.66454091
30PAK31.66099060
31LATS11.61312137
32TRIB31.58723830
33ABL21.54762189
34PTK61.54167841
35NEK91.37698852
36GRK61.32679048
37NTRK31.29955006
38KDR1.28645178
39FGFR21.23804900
40PIK3CA1.22957166
41MST41.21825348
42JAK21.20763085
43MAP3K71.18853316
44TBK11.13463513
45MAP4K21.11842750
46MAP3K41.11471306
47PRKAA21.08872465
48MAP2K31.06400293
49PINK11.05692605
50ERBB21.02622368
51ADRBK21.01183259
52MAP3K101.00924193
53MAP3K30.98224551
54MAP3K140.97666071
55MAPK40.94440989
56JAK10.94361426
57MKNK20.94316629
58MAP3K110.94093131
59MAPK150.93235682
60ZAK0.92862136
61FER0.91594415
62PRKCZ0.90032547
63MET0.89919523
64TNIK0.88316047
65TLK10.84776522
66EPHA30.82654677
67RIPK10.80941002
68MAP2K60.80736851
69EPHB10.80622295
70CDK60.79265256
71PRKACG0.78663375
72STK38L0.78402151
73PRKCE0.77715052
74STK160.75514139
75PNCK0.75430086
76PRKCI0.74640945
77SGK10.74442950
78CAMK2G0.74155223
79TIE10.72876798
80MAPK120.71667279
81DYRK1B0.70373718
82IRAK30.69193447
83CSK0.67901238
84CAMKK20.67668369
85NUAK10.66832609
86PRKAA10.64399227
87GSK3A0.64312545
88RPS6KB10.64096852
89PBK0.63248900
90CSNK1D0.62963093
91MAPK130.62402633
92TESK20.60644818
93PTK20.57963695
94IKBKE0.56798509
95SGK30.55870480
96TAOK20.54882723
97CAMK1D0.54617034
98FGFR10.54499142
99BRD40.54210346
100PRKACA0.53591882
101PDPK10.52309712
102PRKCQ0.52159716
103GRK10.52011406
104TGFBR20.51060222
105WNK10.49265744
106NEK10.48803351
107CSF1R0.48405761
108MAPK70.47870626
109CSNK1G10.47835625
110PRKG10.47624587
111FGFR30.47115012
112MAP2K10.45030838
113PRKACB0.42531360
114EPHA40.41828568
115IGF1R0.40928851
116CDK190.40785880
117CDK40.39335151
118MAP3K50.39271999
119PRKCG0.38882142
120ADRBK10.37963975
121RET0.37914691
122MAP2K20.37912960
123CSNK1A10.36600351
124BMPR20.36373748
125PLK20.36222988
126SGK20.36156232
127MAPKAPK30.36015661
128DYRK1A0.35554235
129MAP3K130.35059915
130CSNK1E0.34397147
131EPHB20.32600425
132ICK0.32247294
133PDK10.32034707
134CAMK40.31958974
135OBSCN0.31431574
136EGFR0.31066318
137CSNK1G30.30203334
138TNK20.29697146
139PRKCA0.29526714
140CSNK1G20.29414587
141PHKG10.29361696
142PHKG20.29361696
143PKN10.28702680
144MAP3K10.28565088
145CSNK2A10.28459307
146MTOR0.28443437
147PRKG20.27783966
148BMX0.26566598
149MAP3K20.26374547
150SGK4940.25789530
151SGK2230.25789530
152AKT30.24882942
153CSNK1A1L0.24301778
154MAP3K60.23486443
155ABL10.21411271
156LATS20.18338922

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.49448006
2Nitrogen metabolism_Homo sapiens_hsa009103.47763125
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34949193
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.26964849
5Arginine biosynthesis_Homo sapiens_hsa002203.05987671
6Complement and coagulation cascades_Homo sapiens_hsa046102.73601064
7Tryptophan metabolism_Homo sapiens_hsa003802.68238439
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66423352
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65809454
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.52754483
11Fatty acid degradation_Homo sapiens_hsa000712.49277569
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37640799
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23138577
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.15559805
15Butanoate metabolism_Homo sapiens_hsa006502.15493311
16Peroxisome_Homo sapiens_hsa041462.09478490
17Chemical carcinogenesis_Homo sapiens_hsa052041.98088903
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95947888
19Histidine metabolism_Homo sapiens_hsa003401.92190097
20Propanoate metabolism_Homo sapiens_hsa006401.91151172
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.89474897
22PPAR signaling pathway_Homo sapiens_hsa033201.88448383
23Fatty acid metabolism_Homo sapiens_hsa012121.80481310
24Caffeine metabolism_Homo sapiens_hsa002321.77835870
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.77310690
26Retinol metabolism_Homo sapiens_hsa008301.70954042
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70013116
28Staphylococcus aureus infection_Homo sapiens_hsa051501.69940686
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68843160
30beta-Alanine metabolism_Homo sapiens_hsa004101.68083791
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.63108931
32Selenocompound metabolism_Homo sapiens_hsa004501.55548304
33Phenylalanine metabolism_Homo sapiens_hsa003601.53708107
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50718508
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50129751
36Bile secretion_Homo sapiens_hsa049761.49290940
37Tyrosine metabolism_Homo sapiens_hsa003501.43697706
38Sulfur metabolism_Homo sapiens_hsa009201.42301830
39Fatty acid elongation_Homo sapiens_hsa000621.38430236
40Fat digestion and absorption_Homo sapiens_hsa049751.37247448
41Pyruvate metabolism_Homo sapiens_hsa006201.35727143
42Folate biosynthesis_Homo sapiens_hsa007901.35528549
43Starch and sucrose metabolism_Homo sapiens_hsa005001.32354446
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.28985414
45Biosynthesis of amino acids_Homo sapiens_hsa012301.18056329
46Steroid biosynthesis_Homo sapiens_hsa001001.17300287
47ABC transporters_Homo sapiens_hsa020101.15311671
48Carbon metabolism_Homo sapiens_hsa012001.13866943
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.03730151
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02602914
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.02336474
52Arginine and proline metabolism_Homo sapiens_hsa003300.98997610
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97786002
54Vitamin digestion and absorption_Homo sapiens_hsa049770.97270156
55Sulfur relay system_Homo sapiens_hsa041220.96900832
56Vitamin B6 metabolism_Homo sapiens_hsa007500.92392590
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91497401
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83906179
59Lysine degradation_Homo sapiens_hsa003100.79346628
60One carbon pool by folate_Homo sapiens_hsa006700.78577364
61Glutathione metabolism_Homo sapiens_hsa004800.71207070
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70730085
63Glycerolipid metabolism_Homo sapiens_hsa005610.68682904
64Pentose phosphate pathway_Homo sapiens_hsa000300.60075067
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59125778
66Fatty acid biosynthesis_Homo sapiens_hsa000610.52820779
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47705894
68Metabolic pathways_Homo sapiens_hsa011000.47334896
69Prion diseases_Homo sapiens_hsa050200.36020689
70Galactose metabolism_Homo sapiens_hsa000520.35880454
71Fructose and mannose metabolism_Homo sapiens_hsa000510.29522489
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29042707
73Linoleic acid metabolism_Homo sapiens_hsa005910.25264060
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20369285
75Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19848191
76Insulin resistance_Homo sapiens_hsa049310.19678327
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.17502497
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.17486528
79Sphingolipid metabolism_Homo sapiens_hsa006000.17145327
80Circadian rhythm_Homo sapiens_hsa047100.06017284
81Glucagon signaling pathway_Homo sapiens_hsa049220.05544302
82Pertussis_Homo sapiens_hsa051330.03515621
83Protein digestion and absorption_Homo sapiens_hsa04974-0.2408822
84Bladder cancer_Homo sapiens_hsa05219-0.2260377
85Ether lipid metabolism_Homo sapiens_hsa00565-0.2109370
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2102747
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2084091
88Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1916001
89Mineral absorption_Homo sapiens_hsa04978-0.1905630
90Hepatitis C_Homo sapiens_hsa05160-0.1800828
91Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1778682
92Regulation of autophagy_Homo sapiens_hsa04140-0.1772105
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1562732
94Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1514471
95Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1469900
96Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1459727
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1322403
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1291324
99Phototransduction_Homo sapiens_hsa04744-0.1290168
100Insulin signaling pathway_Homo sapiens_hsa04910-0.1264306
101African trypanosomiasis_Homo sapiens_hsa05143-0.1156251
102Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0819246
103Serotonergic synapse_Homo sapiens_hsa04726-0.0585101
104N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0528973
105Renin-angiotensin system_Homo sapiens_hsa04614-0.0492866
106Other glycan degradation_Homo sapiens_hsa00511-0.0231324
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0209455
108AMPK signaling pathway_Homo sapiens_hsa04152-0.0190026
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0062588

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