LDOC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1branching involved in labyrinthine layer morphogenesis (GO:0060670)8.43081220
2progesterone metabolic process (GO:0042448)7.29013555
3C21-steroid hormone biosynthetic process (GO:0006700)6.88344961
4G-protein coupled receptor internalization (GO:0002031)6.72602753
5positive regulation of vasculogenesis (GO:2001214)6.46874462
6negative regulation of vascular permeability (GO:0043116)6.41348127
7keratinocyte development (GO:0003334)5.52651129
8cAMP biosynthetic process (GO:0006171)5.36179678
9negative regulation of microtubule polymerization (GO:0031115)5.03946506
10trophectodermal cell differentiation (GO:0001829)5.01578512
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.88123781
12placenta development (GO:0001890)4.53980459
13synaptic vesicle exocytosis (GO:0016079)4.53431425
14ATP synthesis coupled proton transport (GO:0015986)4.50353174
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50353174
16peptidyl-arginine omega-N-methylation (GO:0035247)4.42507080
17regulation of vasculogenesis (GO:2001212)4.30358083
18regulation of lipoprotein metabolic process (GO:0050746)4.28628503
19histone arginine methylation (GO:0034969)4.17411607
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.14604103
21pyrimidine nucleobase catabolic process (GO:0006208)4.13595462
22interferon-gamma secretion (GO:0072643)4.10543755
23C21-steroid hormone metabolic process (GO:0008207)4.09698623
24positive regulation of heart rate (GO:0010460)4.08413316
25cAMP-mediated signaling (GO:0019933)4.07443193
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.90584719
27positive regulation of vasodilation (GO:0045909)3.88943047
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84395094
29peptidyl-arginine N-methylation (GO:0035246)3.78848449
30peptidyl-arginine methylation (GO:0018216)3.78848449
31cell migration in hindbrain (GO:0021535)3.77736899
32dopamine biosynthetic process (GO:0042416)3.65253346
33postsynaptic membrane organization (GO:0001941)3.60122519
34dopamine transport (GO:0015872)3.59963171
35cell differentiation involved in embryonic placenta development (GO:0060706)3.44550515
36regulation of synaptic vesicle exocytosis (GO:2000300)3.41391376
37establishment of mitochondrion localization (GO:0051654)3.39903324
38positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36524029
39cytoskeletal anchoring at plasma membrane (GO:0007016)3.35887337
40neuron recognition (GO:0008038)3.35485094
41glutamate secretion (GO:0014047)3.34567747
42chaperone-mediated protein complex assembly (GO:0051131)3.34307006
43positive regulation of synapse maturation (GO:0090129)3.33229725
44axonal fasciculation (GO:0007413)3.32017414
45ketone biosynthetic process (GO:0042181)3.31166886
46nucleobase catabolic process (GO:0046113)3.28435483
47vocalization behavior (GO:0071625)3.26933574
48gamma-aminobutyric acid transport (GO:0015812)3.23215625
49adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.20019020
50locomotory exploration behavior (GO:0035641)3.19319809
51trophoblast giant cell differentiation (GO:0060707)3.17265564
52presynaptic membrane organization (GO:0097090)3.14423779
53anatomical structure maturation (GO:0071695)3.13520446
54presynaptic membrane assembly (GO:0097105)3.13273605
55cullin deneddylation (GO:0010388)3.13131181
56neuronal ion channel clustering (GO:0045161)3.09368922
57de novo protein folding (GO:0006458)3.09199918
58synapse assembly (GO:0007416)3.08184418
59cerebellar Purkinje cell layer development (GO:0021680)3.04840639
60exploration behavior (GO:0035640)3.03381022
61neuron projection regeneration (GO:0031102)2.98656315
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97428904
63response to insecticide (GO:0017085)2.96671094
64regulation of synaptic vesicle transport (GO:1902803)2.96573256
65transmission of nerve impulse (GO:0019226)2.96142379
66neurotransmitter secretion (GO:0007269)2.95993110
67regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93862442
68dendritic spine morphogenesis (GO:0060997)2.93227159
69labyrinthine layer development (GO:0060711)2.93155681
70positive regulation of synapse assembly (GO:0051965)2.90325869
71neuron cell-cell adhesion (GO:0007158)2.89737364
72regulation of the force of heart contraction (GO:0002026)2.89459939
73regulation of neuronal synaptic plasticity (GO:0048168)2.89093489
74blood vessel maturation (GO:0001955)2.88747539
75cyclic-nucleotide-mediated signaling (GO:0019935)2.86481761
76regulation of vascular permeability (GO:0043114)2.85840361
77histone H4-K12 acetylation (GO:0043983)2.84397142
78bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83734708
79de novo posttranslational protein folding (GO:0051084)2.83652335
80formation of translation preinitiation complex (GO:0001731)2.82514906
81positive regulation of heart contraction (GO:0045823)2.81120189
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80773487
83axon extension (GO:0048675)2.80412215
84auditory behavior (GO:0031223)2.78906350
85histone H2A monoubiquitination (GO:0035518)2.78674388
86cyclic purine nucleotide metabolic process (GO:0052652)2.77948768
87ribosome assembly (GO:0042255)2.77574859
88regulation of vasodilation (GO:0042312)2.76265923
89protein deneddylation (GO:0000338)2.74065438
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73945329
91dendritic spine organization (GO:0097061)2.71772331
92layer formation in cerebral cortex (GO:0021819)2.68967024
93protein maturation by protein folding (GO:0022417)2.67810484
94regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.67501745
95synaptic transmission, glutamatergic (GO:0035249)2.62688011
96negative regulation of blood circulation (GO:1903523)2.62608804
97positive regulation of membrane potential (GO:0045838)2.61245262
98establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.61018741
99mitochondrion transport along microtubule (GO:0047497)2.61018741
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59844108
101regulation of translational termination (GO:0006449)2.59612869
102regulation of vesicle fusion (GO:0031338)2.58968269
103cellular potassium ion homeostasis (GO:0030007)2.58805627
104behavioral response to cocaine (GO:0048148)2.58278556
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.57648918
106energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.56418887
107ATP hydrolysis coupled proton transport (GO:0015991)2.56418887
108ionotropic glutamate receptor signaling pathway (GO:0035235)2.55735549
109chaperone-mediated protein transport (GO:0072321)2.55356764
110cyclic nucleotide biosynthetic process (GO:0009190)2.55319667
111prepulse inhibition (GO:0060134)2.54381530
112synaptic vesicle maturation (GO:0016188)2.54371854
113respiratory electron transport chain (GO:0022904)2.53629554
114synapse organization (GO:0050808)2.53186342
115cerebellar granule cell differentiation (GO:0021707)2.52482322
116protein localization to synapse (GO:0035418)2.52025684
117mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.50771738
118cell junction maintenance (GO:0034331)2.50591504
119synaptic vesicle endocytosis (GO:0048488)2.50587752
120behavioral response to nicotine (GO:0035095)2.50544659
121dopamine receptor signaling pathway (GO:0007212)2.49983077
122neuron projection extension (GO:1990138)2.49530374
123positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.48973473
124neurotransmitter biosynthetic process (GO:0042136)2.48961695
125neurotransmitter transport (GO:0006836)2.47810146
126regulation of mitochondrial translation (GO:0070129)2.47794317
127neuron-neuron synaptic transmission (GO:0007270)2.47009985
128electron transport chain (GO:0022900)2.46997499
129regulation of synapse structural plasticity (GO:0051823)2.46581845
130sodium ion export (GO:0071436)2.46391326
131catecholamine transport (GO:0051937)2.46325898
132substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.45982181
133substrate-independent telencephalic tangential migration (GO:0021826)2.45982181
134regulation of neurotransmitter levels (GO:0001505)2.44857460
135response to auditory stimulus (GO:0010996)2.44099756
136response to histamine (GO:0034776)2.43973522
137nucleobase biosynthetic process (GO:0046112)2.43288479
138dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.42353562
139regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.41858062
140regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.41858062
141regulation of glutamate receptor signaling pathway (GO:1900449)2.41606119
142norepinephrine metabolic process (GO:0042415)2.41414900
143blastocyst development (GO:0001824)2.40877241
144ATP biosynthetic process (GO:0006754)2.40441253
145regulation of clathrin-mediated endocytosis (GO:2000369)2.38389563
146neuromuscular synaptic transmission (GO:0007274)2.37865462
147neuronal action potential propagation (GO:0019227)2.37327193
148membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.37198811
149purine nucleobase biosynthetic process (GO:0009113)2.36990227
150cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36549688
151synaptic vesicle transport (GO:0048489)2.36108538
152establishment of synaptic vesicle localization (GO:0097480)2.36108538
153negative regulation of axon guidance (GO:1902668)2.34529342
154protein insertion into membrane (GO:0051205)2.33974352
155calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.33810622
156innervation (GO:0060384)2.33227710
157axon ensheathment in central nervous system (GO:0032291)2.32794917
158central nervous system myelination (GO:0022010)2.32794917
159positive regulation of neurotransmitter transport (GO:0051590)2.32510440
160glutamate receptor signaling pathway (GO:0007215)2.32372333
161acid secretion (GO:0046717)2.30128472
162dendrite morphogenesis (GO:0048813)2.30013374
163spinal cord development (GO:0021510)2.29550988
164negative regulation of axon extension involved in axon guidance (GO:0048843)2.28169631
165regulation of respiratory system process (GO:0044065)2.27557102
166regulation of postsynaptic membrane potential (GO:0060078)2.25849237
167negative regulation of axon extension (GO:0030517)2.25656426
168regulation of excitatory postsynaptic membrane potential (GO:0060079)2.24635626
169regulation of calcium ion-dependent exocytosis (GO:0017158)2.24569166
170establishment of vesicle localization (GO:0051650)2.23325900
171regulation of synaptic plasticity (GO:0048167)2.21039240
172regulation of synapse assembly (GO:0051963)2.19329490
173regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.19079758
174regulation of neurotransmitter secretion (GO:0046928)2.18724547
175regulation of dendritic spine morphogenesis (GO:0061001)2.17691605
176ear development (GO:0043583)2.17220744

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.76643851
2ESR1_15608294_ChIP-ChIP_MCF-7_Human3.68049525
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.19228318
4POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.99061965
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81719197
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60796761
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.54325172
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.50714697
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.39746985
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.35548057
11NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.27579370
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27499032
13EZH2_27294783_Chip-Seq_ESCs_Mouse2.25171894
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21086057
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.20101663
16ERG_21242973_ChIP-ChIP_JURKAT_Human2.17941721
17EZH2_22144423_ChIP-Seq_EOC_Human2.17882960
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.14947258
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08259348
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.07277403
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.04618184
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01687051
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.00882980
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.00071003
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.97466906
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.96791749
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95168409
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94688426
29ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93989588
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.93646896
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91642876
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.91401737
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.89963756
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.87573203
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.87011683
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85369892
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81150265
38SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.79348312
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.77155335
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75151605
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74465989
42NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71648562
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71523000
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71066033
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.70642972
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69282160
47REST_21632747_ChIP-Seq_MESCs_Mouse1.67045634
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.65782696
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65714718
50RBPJ_22232070_ChIP-Seq_NCS_Mouse1.65523281
51XRN2_22483619_ChIP-Seq_HELA_Human1.64914917
52OCT4_18692474_ChIP-Seq_MEFs_Mouse1.64054954
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61718506
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61718506
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61718506
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.61025021
57SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.60091164
58AR_21909140_ChIP-Seq_LNCAP_Human1.57451985
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.57356367
60DROSHA_22980978_ChIP-Seq_HELA_Human1.55718880
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53522231
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.52457525
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50379536
64KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49145665
65CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.47540501
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45378099
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44680910
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44530765
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42393812
70* RNF2_27304074_Chip-Seq_NSC_Mouse1.42123158
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.39898080
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.39615023
73ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37473623
74TTF2_22483619_ChIP-Seq_HELA_Human1.36806593
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36372829
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.34730674
77CTCF_27219007_Chip-Seq_Bcells_Human1.32807671
78NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30784936
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28923424
80SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27582073
81OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27565363
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25101286
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24778377
84SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.24629574
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22942789
86GABP_19822575_ChIP-Seq_HepG2_Human1.21590299
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21258472
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20961205
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.19927964
90RING1B_27294783_Chip-Seq_NPCs_Mouse1.18094053
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.17543600
92CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17324602
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.16151409
94DCP1A_22483619_ChIP-Seq_HELA_Human1.15377113
95EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15027609
96RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.14230286
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13964991
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13123612
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.13004754
100RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12845468
101EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12845468
102NANOG_16518401_ChIP-PET_MESCs_Mouse1.12633071
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.12234937
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11939193
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11564874
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.10873631
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10788328
108KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10703212
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10271019
110NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10010602
111EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08859760
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08775046
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08272780
114BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08154456
115ZNF263_19887448_ChIP-Seq_K562_Human1.07025258
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05559932
117CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04655688
118KDM2B_26808549_Chip-Seq_K562_Human1.04097774
119TET1_21451524_ChIP-Seq_MESCs_Mouse1.02908515
120* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01148404
121SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00735487
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00719665
123NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00648050
124NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.99855243
125POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98981599
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98493538
127POU5F1_16518401_ChIP-PET_MESCs_Mouse0.97902268
128GBX2_23144817_ChIP-Seq_PC3_Human0.97231165
129GATA1_26923725_Chip-Seq_HPCs_Mouse0.95948636
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95443263
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95401697
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95073900
133SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93701224
134YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93069824
135TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92682252
136PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92681405
137TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92007325
138JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91197736
139* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91009514
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.90504513
141CREB1_26743006_Chip-Seq_LNCaP_Human0.90084878
142HTT_18923047_ChIP-ChIP_STHdh_Human0.89433576
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.88881167
144ZFP281_27345836_Chip-Seq_ESCs_Mouse0.88644904
145ZNF274_21170338_ChIP-Seq_K562_Hela0.88541322
146RACK7_27058665_Chip-Seq_MCF-7_Human0.88381461
147CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87654721
148MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87278306
149FOXP1_21924763_ChIP-Seq_HESCs_Human0.86551916
150TRIM28_21343339_ChIP-Seq_HEK293_Human0.84261719
151AHR_22903824_ChIP-Seq_MCF-7_Human0.83589018
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80960369
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79528273
154FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.79128312
155P68_20966046_ChIP-Seq_HELA_Human0.75283888
156SMC4_20622854_ChIP-Seq_HELA_Human0.74189367
157CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74072420
158NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.73890866
159CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73542687

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003123_paternal_imprinting4.90076253
2MP0003122_maternal_imprinting4.02182999
3MP0004859_abnormal_synaptic_plasticity3.99990402
4MP0003880_abnormal_central_pattern3.49909838
5MP0004272_abnormal_basement_membrane3.27746582
6MP0003121_genomic_imprinting3.19001917
7MP0003221_abnormal_cardiomyocyte_apopto3.11849785
8MP0003787_abnormal_imprinting2.91977047
9MP0004264_abnormal_extraembryonic_tissu2.76485802
10MP0003635_abnormal_synaptic_transmissio2.61392318
11MP0003705_abnormal_hypodermis_morpholog2.44148670
12MP0000013_abnormal_adipose_tissue2.40031896
13MP0009046_muscle_twitch2.38148775
14MP0005623_abnormal_meninges_morphology2.12722891
15MP0001440_abnormal_grooming_behavior2.11236988
16MP0004270_analgesia2.00926161
17MP0002063_abnormal_learning/memory/cond2.00840772
18MP0002572_abnormal_emotion/affect_behav1.96730078
19MP0002064_seizures1.95567119
20MP0004957_abnormal_blastocyst_morpholog1.78106826
21MP0009780_abnormal_chondrocyte_physiolo1.77237663
22MP0005646_abnormal_pituitary_gland1.75644192
23MP0009745_abnormal_behavioral_response1.72645799
24MP0002909_abnormal_adrenal_gland1.67937576
25MP0004084_abnormal_cardiac_muscle1.66528971
26MP0002086_abnormal_extraembryonic_tissu1.63709614
27MP0002295_abnormal_pulmonary_circulatio1.63448927
28MP0005499_abnormal_olfactory_system1.60266545
29MP0005394_taste/olfaction_phenotype1.60266545
30MP0002272_abnormal_nervous_system1.59487998
31MP0002184_abnormal_innervation1.58982398
32MP0001905_abnormal_dopamine_level1.54643438
33MP0003186_abnormal_redox_activity1.51643427
34MP0008775_abnormal_heart_ventricle1.49532604
35MP0004885_abnormal_endolymph1.48815689
36MP0003693_abnormal_embryo_hatching1.48659450
37MP0006276_abnormal_autonomic_nervous1.46654782
38MP0010352_gastrointestinal_tract_polyps1.41344843
39MP0002733_abnormal_thermal_nociception1.41122633
40MP0001984_abnormal_olfaction1.39537727
41MP0001529_abnormal_vocalization1.38646301
42MP0002249_abnormal_larynx_morphology1.38530680
43MP0002653_abnormal_ependyma_morphology1.37663890
44MP0002837_dystrophic_cardiac_calcinosis1.36009240
45MP0003942_abnormal_urinary_system1.34677858
46MP0002734_abnormal_mechanical_nocicepti1.34664016
47MP0003119_abnormal_digestive_system1.31937357
48MP0000566_synostosis1.29343589
49MP0005187_abnormal_penis_morphology1.27096881
50MP0008789_abnormal_olfactory_epithelium1.26292598
51MP0000003_abnormal_adipose_tissue1.24719502
52MP0001501_abnormal_sleep_pattern1.22906725
53MP0003566_abnormal_cell_adhesion1.22777264
54MP0010030_abnormal_orbit_morphology1.22360340
55MP0001697_abnormal_embryo_size1.21562808
56MP0004811_abnormal_neuron_physiology1.21344718
57MP0001968_abnormal_touch/_nociception1.21323015
58MP0000579_abnormal_nail_morphology1.19865731
59MP0001970_abnormal_pain_threshold1.18629546
60MP0000778_abnormal_nervous_system1.18169046
61MP0003567_abnormal_fetal_cardiomyocyte1.18067705
62MP0004197_abnormal_fetal_growth/weight/1.17912016
63MP0000049_abnormal_middle_ear1.16242382
64MP0001730_embryonic_growth_arrest1.16063552
65MP0008569_lethality_at_weaning1.15450043
66MP0005423_abnormal_somatic_nervous1.15431255
67MP0004145_abnormal_muscle_electrophysio1.15092892
68MP0001502_abnormal_circadian_rhythm1.11541497
69MP0004924_abnormal_behavior1.11378249
70MP0005386_behavior/neurological_phenoty1.11378249
71MP0003938_abnormal_ear_development1.08745448
72MP0001486_abnormal_startle_reflex1.07007105
73MP0002735_abnormal_chemical_nociception1.06607261
74MP0002736_abnormal_nociception_after1.06270721
75MP0008932_abnormal_embryonic_tissue1.05316120
76MP0004133_heterotaxia1.05143661
77MP0003890_abnormal_embryonic-extraembry1.04331734
78MP0002752_abnormal_somatic_nervous1.03518111
79MP0008877_abnormal_DNA_methylation1.03051475
80MP0002822_catalepsy1.02083021
81MP0000955_abnormal_spinal_cord1.01918816
82MP0001188_hyperpigmentation1.01159200
83MP0000631_abnormal_neuroendocrine_gland1.00842096
84MP0000534_abnormal_ureter_morphology1.00628576
85MP0002067_abnormal_sensory_capabilities1.00134284
86MP0003011_delayed_dark_adaptation0.99550741
87MP0006292_abnormal_olfactory_placode0.98558156
88MP0002088_abnormal_embryonic_growth/wei0.97901108
89MP0003632_abnormal_nervous_system0.97757920
90MP0001672_abnormal_embryogenesis/_devel0.97670462
91MP0005380_embryogenesis_phenotype0.97670462
92MP0002066_abnormal_motor_capabilities/c0.97212911
93MP0003984_embryonic_growth_retardation0.97192953
94MP0004510_myositis0.96963027
95MP0000462_abnormal_digestive_system0.96609041
96MP0006035_abnormal_mitochondrial_morpho0.96455388
97MP0000026_abnormal_inner_ear0.93949379
98MP0003315_abnormal_perineum_morphology0.93634060
99MP0003329_amyloid_beta_deposits0.92127698
100MP0004036_abnormal_muscle_relaxation0.91903652
101MP0002557_abnormal_social/conspecific_i0.91611056
102MP0001177_atelectasis0.91561359
103MP0002084_abnormal_developmental_patter0.91511693
104MP0002127_abnormal_cardiovascular_syste0.90289399
105MP0002152_abnormal_brain_morphology0.88991437
106MP0004085_abnormal_heartbeat0.86105036
107MP0002234_abnormal_pharynx_morphology0.85354928
108MP0002080_prenatal_lethality0.84858436
109MP0003879_abnormal_hair_cell0.83942965
110MP0001756_abnormal_urination0.83476038
111MP0002229_neurodegeneration0.82791114
112MP0005551_abnormal_eye_electrophysiolog0.82753180
113MP0004142_abnormal_muscle_tone0.82750159
114MP0010386_abnormal_urinary_bladder0.82517140
115MP0002069_abnormal_eating/drinking_beha0.82377677
116MP0001963_abnormal_hearing_physiology0.81381695
117MP0003183_abnormal_peptide_metabolism0.80044021
118MP0003861_abnormal_nervous_system0.78972914
119MP0006054_spinal_hemorrhage0.78330566
120MP0005023_abnormal_wound_healing0.77863972
121MP0004858_abnormal_nervous_system0.77417454
122MP0004742_abnormal_vestibular_system0.77047039
123MP0002882_abnormal_neuron_morphology0.76870586
124MP0001299_abnormal_eye_distance/0.75300866
125MP0002116_abnormal_craniofacial_bone0.74174988
126MP0003111_abnormal_nucleus_morphology0.73637161
127MP0002332_abnormal_exercise_endurance0.73186194
128MP0000350_abnormal_cell_proliferation0.73169636
129MP0000538_abnormal_urinary_bladder0.73032613
130MP0000537_abnormal_urethra_morphology0.72366401
131MP0008770_decreased_survivor_rate0.72153014
132MP0002102_abnormal_ear_morphology0.71993643
133MP0005645_abnormal_hypothalamus_physiol0.70541403
134MP0002751_abnormal_autonomic_nervous0.70200662
135MP0000751_myopathy0.69746618
136MP0003755_abnormal_palate_morphology0.68858348
137MP0002160_abnormal_reproductive_system0.68438855
138MP0004883_abnormal_blood_vessel0.67160444
139MP0002081_perinatal_lethality0.66157440
140MP0008872_abnormal_physiological_respon0.66038470
141MP0002638_abnormal_pupillary_reflex0.65591082
142MP0000427_abnormal_hair_cycle0.62106865
143MP0002233_abnormal_nose_morphology0.61685164
144MP0001340_abnormal_eyelid_morphology0.61498576
145MP0002938_white_spotting0.61331503
146MP0006072_abnormal_retinal_apoptosis0.60632290

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.21052673
2Limb dystonia (HP:0002451)5.05325593
3Abnormality of the labia minora (HP:0012880)4.25471839
4Visual hallucinations (HP:0002367)4.03740993
5Pili torti (HP:0003777)3.83855858
6Septate vagina (HP:0001153)3.72566900
7Progressive cerebellar ataxia (HP:0002073)3.71613514
8Abnormality of glycolysis (HP:0004366)3.60502772
9Increased serum pyruvate (HP:0003542)3.60502772
10Selective tooth agenesis (HP:0001592)3.29861052
11Focal seizures (HP:0007359)3.23695454
12Right ventricular cardiomyopathy (HP:0011663)3.21205714
13Cerebral hypomyelination (HP:0006808)3.11961676
14Acute necrotizing encephalopathy (HP:0006965)2.98569567
15Failure to thrive in infancy (HP:0001531)2.88363726
16Abnormal mitochondria in muscle tissue (HP:0008316)2.76429155
17Focal motor seizures (HP:0011153)2.73453779
18Impaired vibration sensation in the lower limbs (HP:0002166)2.71236168
19Epileptiform EEG discharges (HP:0011182)2.67317771
20Ankle clonus (HP:0011448)2.66379302
21Poor suck (HP:0002033)2.63135838
22Concave nail (HP:0001598)2.61298780
23EEG with generalized epileptiform discharges (HP:0011198)2.59494740
24Retinal dysplasia (HP:0007973)2.59226953
25Atonic seizures (HP:0010819)2.58358422
26Abnormal eating behavior (HP:0100738)2.55802152
27Gait imbalance (HP:0002141)2.52202627
28Delusions (HP:0000746)2.51843643
29Hypsarrhythmia (HP:0002521)2.51499588
30Abnormality of the lower motor neuron (HP:0002366)2.49809538
31Emotional lability (HP:0000712)2.46643860
32Mitochondrial inheritance (HP:0001427)2.46408096
33Amyotrophic lateral sclerosis (HP:0007354)2.43372397
34Morphological abnormality of the pyramidal tract (HP:0002062)2.40315809
35Horizontal nystagmus (HP:0000666)2.39580282
36Increased CSF lactate (HP:0002490)2.37544793
37Progressive macrocephaly (HP:0004481)2.34012017
38Hemiparesis (HP:0001269)2.32730185
39Cerebral inclusion bodies (HP:0100314)2.30613055
40Progressive external ophthalmoplegia (HP:0000590)2.30351306
41Type II lissencephaly (HP:0007260)2.27139738
42Absence seizures (HP:0002121)2.25517819
43Supranuclear gaze palsy (HP:0000605)2.24852760
44Spastic gait (HP:0002064)2.24733539
45Sleep apnea (HP:0010535)2.24251475
46Resting tremor (HP:0002322)2.21305029
47Febrile seizures (HP:0002373)2.20946345
48Abnormality of the corticospinal tract (HP:0002492)2.20769093
49Postnatal microcephaly (HP:0005484)2.20308273
50Birth length less than 3rd percentile (HP:0003561)2.18213259
51Polyphagia (HP:0002591)2.17726677
52Acute encephalopathy (HP:0006846)2.16465726
53Generalized tonic-clonic seizures (HP:0002069)2.16436542
54Increased hepatocellular lipid droplets (HP:0006565)2.15683131
55Epileptic encephalopathy (HP:0200134)2.15560437
56Dysdiadochokinesis (HP:0002075)2.15083092
57Insomnia (HP:0100785)2.14677741
58Hyperacusis (HP:0010780)2.13338559
59Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.13086077
60Dialeptic seizures (HP:0011146)2.12916723
61Multiple enchondromatosis (HP:0005701)2.12156173
62Spinal cord compression (HP:0002176)2.11518765
63Abnormal number of incisors (HP:0011064)2.09921623
64Pointed chin (HP:0000307)2.08706009
65Akinesia (HP:0002304)2.07905054
66Ulnar claw (HP:0001178)2.07383157
67Overriding aorta (HP:0002623)2.06262755
68Diplopia (HP:0000651)2.05460304
69Abnormality of binocular vision (HP:0011514)2.05460304
70Lissencephaly (HP:0001339)2.04289174
71J-shaped sella turcica (HP:0002680)2.04277890
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.04201851
73Buphthalmos (HP:0000557)2.04108902
74Dyskinesia (HP:0100660)2.02334683
75Adenoma sebaceum (HP:0009720)2.02108997
76Angiofibromas (HP:0010615)2.02108997
77Pachygyria (HP:0001302)2.02055621
78Torticollis (HP:0000473)2.01964329
79Muscular hypotonia of the trunk (HP:0008936)2.01679157
80Leukodystrophy (HP:0002415)1.99052323
81Hepatocellular necrosis (HP:0001404)1.96901784
82Nephrogenic diabetes insipidus (HP:0009806)1.96499287
83Hypokinesia (HP:0002375)1.96284274
84Congenital primary aphakia (HP:0007707)1.95456480
85Hypoventilation (HP:0002791)1.95258014
86Atrophy/Degeneration involving motor neurons (HP:0007373)1.94908702
87Elfin facies (HP:0004428)1.94601597
88Drooling (HP:0002307)1.91943267
89Insidious onset (HP:0003587)1.91506553
90Termporal pattern (HP:0011008)1.91506553
91Congenital glaucoma (HP:0001087)1.91035894
92Aplasia/Hypoplasia of the brainstem (HP:0007362)1.90875787
93Hypoplasia of the brainstem (HP:0002365)1.90875787
94Aplastic anemia (HP:0001915)1.90756674
95Webbed neck (HP:0000465)1.87645217
96Abnormality of the aortic arch (HP:0012303)1.87446659
97CNS hypomyelination (HP:0003429)1.86501502
98Medial flaring of the eyebrow (HP:0010747)1.85451954
99Double outlet right ventricle (HP:0001719)1.85394335
100Congenital malformation of the right heart (HP:0011723)1.85394335
101Renal duplication (HP:0000075)1.85191522
102Diminished movement (HP:0002374)1.85022005
103Action tremor (HP:0002345)1.84913923
104Exercise intolerance (HP:0003546)1.84081410
105Curly hair (HP:0002212)1.83988582
106Spastic tetraplegia (HP:0002510)1.83566193
107Deep palmar crease (HP:0006191)1.82266349
108Ragged-red muscle fibers (HP:0003200)1.81140022
109Dysmetria (HP:0001310)1.80773401
110Urinary urgency (HP:0000012)1.78696522
111Renovascular hypertension (HP:0100817)1.78633155
112Multifactorial inheritance (HP:0001426)1.78468051
113Amblyopia (HP:0000646)1.78410709
114Impaired pain sensation (HP:0007328)1.77734375
115Abnormality of pain sensation (HP:0010832)1.77734375
116Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76998133
117Agitation (HP:0000713)1.75633708
118Muscle fibrillation (HP:0010546)1.75410374
119Renal dysplasia (HP:0000110)1.75121838
120Lipid accumulation in hepatocytes (HP:0006561)1.75103531
121High anterior hairline (HP:0009890)1.74718230
122Broad-based gait (HP:0002136)1.74269933
123Specific learning disability (HP:0001328)1.73744602
124Shoulder girdle muscle weakness (HP:0003547)1.73085963
125Anxiety (HP:0000739)1.72102019
126Delayed puberty (HP:0000823)1.71553272
127Focal dystonia (HP:0004373)1.71355161
128Myotonia (HP:0002486)1.71263022
129Bronchomalacia (HP:0002780)1.70500828
130Preauricular skin tag (HP:0000384)1.70342718
131Achilles tendon contracture (HP:0001771)1.70236397
132Progressive inability to walk (HP:0002505)1.70230567
133Hand muscle atrophy (HP:0009130)1.69978020
134Vaginal atresia (HP:0000148)1.69957064
135Testicular atrophy (HP:0000029)1.69696622
136Urinary bladder sphincter dysfunction (HP:0002839)1.69335757
137Hyperventilation (HP:0002883)1.69194332
138Tetraplegia (HP:0002445)1.66273988
139Esotropia (HP:0000565)1.66010670
140Hypoplastic pelvis (HP:0008839)1.65635335
141Genital tract atresia (HP:0001827)1.65210400
142Depression (HP:0000716)1.64844831
143Enlarged penis (HP:0000040)1.63952458
144Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.63312004
145Neuroblastoma (HP:0003006)1.63312004
146Primitive neuroectodermal tumor (HP:0030065)1.63312004
147Neuroblastic tumors (HP:0004376)1.63312004
148Morphological abnormality of the middle ear (HP:0008609)1.62755983
149Generalized hypotonia (HP:0001290)1.60733838
150Hydroureter (HP:0000072)1.60336290
151Excessive salivation (HP:0003781)1.60240596
152Obstructive sleep apnea (HP:0002870)1.60063839
153Degeneration of the lateral corticospinal tracts (HP:0002314)1.59964585
154Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.59964585
155Truncal ataxia (HP:0002078)1.58259228
156Status epilepticus (HP:0002133)1.54103311
157Broad distal phalanx of finger (HP:0009836)1.53642328
158Shawl scrotum (HP:0000049)1.51904430
159Intention tremor (HP:0002080)1.50868778
160Craniofacial dystonia (HP:0012179)1.47833296
161Heterochromia iridis (HP:0001100)1.45962356
162Hypercortisolism (HP:0001578)1.43724060
163Polymicrogyria (HP:0002126)1.42963166
164Dental crowding (HP:0000678)1.41310524
165Growth hormone excess (HP:0000845)1.39981794
166Cortical dysplasia (HP:0002539)1.39768628

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.55580084
2PNCK4.19049955
3PRKD33.33907800
4MST43.23334923
5LIMK13.06790860
6NTRK32.46805225
7TESK12.34563229
8EPHA22.34126406
9MAP3K92.28061328
10WEE12.23181934
11TSSK62.23121158
12NEK12.20305754
13MARK12.16002131
14MINK12.12457610
15SIK12.11876234
16MAP3K122.10641183
17PLK21.92973699
18LATS21.85974058
19NME11.84335421
20GRK51.72292819
21MAP3K41.65687820
22ALK1.64854170
23VRK21.60634894
24TRIM281.54212583
25STK101.53296438
26DAPK21.51239436
27RPS6KB21.48180646
28BCKDK1.39171570
29PKN21.38779229
30MUSK1.31448563
31MAPKAPK31.30272489
32PINK11.30094989
33TRIB31.29965897
34BUB11.27050522
35CASK1.22294108
36NTRK11.20117716
37PLK31.19874238
38EIF2AK11.12724657
39MAP2K41.11273890
40CDK181.04804971
41PRKD21.04207759
42AKT31.02186661
43CDK151.02186648
44LRRK21.02154389
45PRKCG1.01816577
46RPS6KA21.01404800
47FER0.98658654
48GRK60.98519831
49PTK20.96983247
50TYRO30.96773127
51ROCK20.96717648
52CDK140.95416829
53KSR10.94455805
54CDK11A0.93866380
55BCR0.93480794
56SCYL20.92452749
57FGR0.90765342
58PAK30.89998634
59PAK40.89534926
60CAMK2D0.89524462
61NTRK20.88964961
62UHMK10.88097006
63FRK0.87728557
64PRKG20.87577354
65MAP2K20.87464169
66STK160.87171879
67CAMKK10.85027014
68CDC42BPA0.83416079
69CSNK1E0.81178324
70CSNK1A1L0.80859759
71CAMK2B0.80786668
72CSNK1G10.77955013
73CDK50.77901676
74BRSK10.75866443
75PRKCI0.75498922
76KSR20.74906288
77PRKCZ0.74565495
78MAPKAPK50.73084619
79DYRK30.72572666
80PAK10.72481565
81CDK190.71408087
82PIM20.70744925
83TTK0.70210449
84PRKCE0.69724928
85CAMK10.68876733
86SIK30.68409248
87AURKA0.67369578
88DAPK10.67343672
89WNK30.66759967
90IRAK20.65009201
91DYRK1B0.64625190
92ARAF0.64357857
93RIPK10.64205713
94CDC70.64130458
95GRK10.63370022
96ADRBK10.63354671
97ICK0.62812783
98MAP2K10.62003258
99PIK3CA0.61802760
100EPHB20.61623841
101SGK2230.61369710
102SGK4940.61369710
103SRPK10.61124465
104CSNK1G30.60660777
105PDK30.60489102
106PDK40.60489102
107CAMK2G0.60054824
108EPHA40.59788020
109DYRK1A0.59078426
110CAMK2A0.58655236
111CSNK1G20.58171799
112MAP3K80.57685317
113PAK60.57617947
114STK380.56306491
115BRAF0.56178221
116PLK10.56087849
117PDK10.55561637
118ILK0.54933929
119CDK120.54192361
120MAP4K20.53559542
121TESK20.53135350
122MAP3K110.51581408
123NEK60.51070566
124MAPK130.50831059
125FGFR20.50308697
126PRKCH0.49049483
127PHKG10.47963865
128PHKG20.47963865
129TAF10.47528388
130MARK20.46192467
131DAPK30.45785262
132RET0.45650094
133MAP2K70.45282456
134PTK2B0.44579539
135AKT20.44322372
136PDPK10.43760657
137CSNK1A10.42849655
138LMTK20.42757458
139TAOK20.42497891
140SIK20.40498655
141EIF2AK30.39797229
142TAOK10.39754291
143CSNK2A20.39207668
144DYRK20.38647499

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.33359385
2Oxidative phosphorylation_Homo sapiens_hsa001903.20758417
3Parkinsons disease_Homo sapiens_hsa050123.09695604
4Proteasome_Homo sapiens_hsa030502.86014035
5Nicotine addiction_Homo sapiens_hsa050332.59965730
6Alzheimers disease_Homo sapiens_hsa050102.15952974
7Collecting duct acid secretion_Homo sapiens_hsa049662.15249118
8Long-term potentiation_Homo sapiens_hsa047202.12290879
9Huntingtons disease_Homo sapiens_hsa050162.08029087
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92449890
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87314926
12Cardiac muscle contraction_Homo sapiens_hsa042601.84655575
13Amphetamine addiction_Homo sapiens_hsa050311.82324444
14Vibrio cholerae infection_Homo sapiens_hsa051101.75341465
15Glutamatergic synapse_Homo sapiens_hsa047241.67615365
16Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.66663340
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65547419
18GABAergic synapse_Homo sapiens_hsa047271.64765197
19Gap junction_Homo sapiens_hsa045401.62730175
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.61829409
21Long-term depression_Homo sapiens_hsa047301.60735755
22Dopaminergic synapse_Homo sapiens_hsa047281.60281700
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53430652
24RNA polymerase_Homo sapiens_hsa030201.50332539
25Oocyte meiosis_Homo sapiens_hsa041141.47746650
26RNA transport_Homo sapiens_hsa030131.44557492
27Cocaine addiction_Homo sapiens_hsa050301.43371159
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40916026
29Vitamin B6 metabolism_Homo sapiens_hsa007501.37966167
30Circadian entrainment_Homo sapiens_hsa047131.36935053
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32858603
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27582125
33Estrogen signaling pathway_Homo sapiens_hsa049151.22523814
34Cholinergic synapse_Homo sapiens_hsa047251.22273119
35Ribosome_Homo sapiens_hsa030101.16833887
36Spliceosome_Homo sapiens_hsa030401.15033563
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13627596
38Phototransduction_Homo sapiens_hsa047441.12494919
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12240553
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10163082
41Serotonergic synapse_Homo sapiens_hsa047261.10161047
42Linoleic acid metabolism_Homo sapiens_hsa005911.09046717
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07502633
44Gastric acid secretion_Homo sapiens_hsa049711.05906923
45Tight junction_Homo sapiens_hsa045301.04556555
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04511680
47Sulfur relay system_Homo sapiens_hsa041221.02872253
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02821660
49Taste transduction_Homo sapiens_hsa047421.00233156
50Steroid biosynthesis_Homo sapiens_hsa001000.99641972
51GnRH signaling pathway_Homo sapiens_hsa049120.99441666
52Hippo signaling pathway_Homo sapiens_hsa043900.97959651
53Salivary secretion_Homo sapiens_hsa049700.94791023
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94545639
55Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93534028
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93422374
57Morphine addiction_Homo sapiens_hsa050320.89756626
58Folate biosynthesis_Homo sapiens_hsa007900.89567741
59Insulin secretion_Homo sapiens_hsa049110.89562223
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87653111
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87593478
62Protein export_Homo sapiens_hsa030600.87354541
63Axon guidance_Homo sapiens_hsa043600.87222244
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.86907535
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84397300
66Hedgehog signaling pathway_Homo sapiens_hsa043400.82217758
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81148856
68Dilated cardiomyopathy_Homo sapiens_hsa054140.80868696
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80373329
70AMPK signaling pathway_Homo sapiens_hsa041520.80128167
71Oxytocin signaling pathway_Homo sapiens_hsa049210.79106944
72Arginine and proline metabolism_Homo sapiens_hsa003300.78070954
73Renal cell carcinoma_Homo sapiens_hsa052110.76668779
74cAMP signaling pathway_Homo sapiens_hsa040240.75248192
75beta-Alanine metabolism_Homo sapiens_hsa004100.75160077
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74310446
77Phenylalanine metabolism_Homo sapiens_hsa003600.73136734
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72973119
79Basal cell carcinoma_Homo sapiens_hsa052170.72556254
80Nucleotide excision repair_Homo sapiens_hsa034200.72024075
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69684739
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69681469
83Fatty acid elongation_Homo sapiens_hsa000620.69067053
84Butanoate metabolism_Homo sapiens_hsa006500.68790193
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68161236
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67790840
87Regulation of autophagy_Homo sapiens_hsa041400.67472633
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65382531
89Wnt signaling pathway_Homo sapiens_hsa043100.65113579
90Pyrimidine metabolism_Homo sapiens_hsa002400.64980946
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.64240378
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63891058
93Renin secretion_Homo sapiens_hsa049240.63233261
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.63180755
95Mismatch repair_Homo sapiens_hsa034300.63078874
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.63008283
97Olfactory transduction_Homo sapiens_hsa047400.61998671
98VEGF signaling pathway_Homo sapiens_hsa043700.60461296
99Phagosome_Homo sapiens_hsa041450.60423746
100Ether lipid metabolism_Homo sapiens_hsa005650.59604644
101Glioma_Homo sapiens_hsa052140.59541274
102Thyroid hormone synthesis_Homo sapiens_hsa049180.59041929
103Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58960921
104Pyruvate metabolism_Homo sapiens_hsa006200.58737186
105Calcium signaling pathway_Homo sapiens_hsa040200.57820954
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57608676
107Rap1 signaling pathway_Homo sapiens_hsa040150.57100453
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54727398
109Choline metabolism in cancer_Homo sapiens_hsa052310.54468649
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54010292
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53042533
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52778165
113ErbB signaling pathway_Homo sapiens_hsa040120.52729880
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51803182
115mRNA surveillance pathway_Homo sapiens_hsa030150.51538424
116cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51140501
117Glucagon signaling pathway_Homo sapiens_hsa049220.50963715
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50520498
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.50510687
120Dorso-ventral axis formation_Homo sapiens_hsa043200.50420950
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50017480
122Melanogenesis_Homo sapiens_hsa049160.49500411
123mTOR signaling pathway_Homo sapiens_hsa041500.49167101
124Thyroid cancer_Homo sapiens_hsa052160.48692015
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.47869639
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47573999
127DNA replication_Homo sapiens_hsa030300.44278187
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43652592
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43640150
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43341521
131Biosynthesis of amino acids_Homo sapiens_hsa012300.42419233
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41467170
133Fat digestion and absorption_Homo sapiens_hsa049750.40840312
134Type II diabetes mellitus_Homo sapiens_hsa049300.40808780
135Melanoma_Homo sapiens_hsa052180.40458036
136Endometrial cancer_Homo sapiens_hsa052130.39524666
137Basal transcription factors_Homo sapiens_hsa030220.38998915
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38054494
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37953312
140Pancreatic secretion_Homo sapiens_hsa049720.36827573
141Fructose and mannose metabolism_Homo sapiens_hsa000510.36175575

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