LDLRAD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chemical homeostasis within a tissue (GO:0048875)9.75599271
2left/right pattern formation (GO:0060972)9.04049599
3regulation of cilium movement (GO:0003352)8.37097148
4vitamin transmembrane transport (GO:0035461)7.27276664
5response to xenobiotic stimulus (GO:0009410)6.84021246
6ventricular system development (GO:0021591)6.60210080
7microtubule bundle formation (GO:0001578)6.47879483
8intraciliary transport (GO:0042073)6.34580286
9diterpenoid biosynthetic process (GO:0016102)6.18870508
10cilium organization (GO:0044782)6.12581858
11cilium assembly (GO:0042384)5.95942607
12pyrimidine-containing compound transmembrane transport (GO:0072531)5.71481462
13lung lobe morphogenesis (GO:0060463)5.28924652
14negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.26313038
15protein localization to cilium (GO:0061512)5.17210864
16establishment of apical/basal cell polarity (GO:0035089)5.13312886
17centriole assembly (GO:0098534)5.04763321
18negative regulation of T cell differentiation in thymus (GO:0033085)5.02672743
19regulation of microtubule-based movement (GO:0060632)4.90417473
20positive regulation of endothelial cell differentiation (GO:0045603)4.74596700
21negative regulation of immunoglobulin mediated immune response (GO:0002890)4.73300451
22negative regulation of B cell mediated immunity (GO:0002713)4.73300451
23ethanol metabolic process (GO:0006067)4.71640825
24cellular component assembly involved in morphogenesis (GO:0010927)4.70426152
25microtubule-based movement (GO:0007018)4.59870396
26ethanol oxidation (GO:0006069)4.57175918
27regulation of interleukin-13 production (GO:0032656)4.56364992
28cilium movement (GO:0003341)4.49384437
29sperm capacitation (GO:0048240)4.49232731
30terpenoid biosynthetic process (GO:0016114)4.48376466
31cilium morphogenesis (GO:0060271)4.42684602
32establishment or maintenance of monopolar cell polarity (GO:0061339)4.38370540
33establishment of monopolar cell polarity (GO:0061162)4.38370540
34cellular response to nitric oxide (GO:0071732)4.38269202
35regulation of germinal center formation (GO:0002634)4.37020389
36retinoic acid metabolic process (GO:0042573)4.34166027
37cell projection assembly (GO:0030031)4.29881084
38regulation of endothelial cell differentiation (GO:0045601)4.28016005
39axonemal dynein complex assembly (GO:0070286)4.15881715
40cilium or flagellum-dependent cell motility (GO:0001539)4.10874777
41morphogenesis of an endothelium (GO:0003159)4.05484101
42endothelial tube morphogenesis (GO:0061154)4.05484101
43fatty acid elongation (GO:0030497)4.03164000
44positive regulation of tolerance induction (GO:0002645)4.00536478
45nucleoside diphosphate phosphorylation (GO:0006165)3.92484831
46cytoplasmic microtubule organization (GO:0031122)3.83048457
47lung vasculature development (GO:0060426)3.82986191
48sodium ion homeostasis (GO:0055078)3.77518194
49glomerular epithelial cell development (GO:0072310)3.67674268
50blood vessel maturation (GO:0001955)3.66121294
51lymphangiogenesis (GO:0001946)3.63934095
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.62520064
53mesodermal cell differentiation (GO:0048333)3.56027364
54microtubule depolymerization (GO:0007019)3.53638986
55primary alcohol catabolic process (GO:0034310)3.49512741
56negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.47552063
57primary alcohol metabolic process (GO:0034308)3.47007149
58negative regulation of humoral immune response (GO:0002921)3.45621405
59retinol metabolic process (GO:0042572)3.42044758
60response to nitric oxide (GO:0071731)3.41901347
61regulation of tolerance induction (GO:0002643)3.39329928
62regulation of vasculogenesis (GO:2001212)3.39144646
63glutathione derivative biosynthetic process (GO:1901687)3.38999241
64glutathione derivative metabolic process (GO:1901685)3.38999241
65tolerance induction (GO:0002507)3.37729535
66epithelial cilium movement (GO:0003351)3.36987511
67microtubule polymerization or depolymerization (GO:0031109)3.35488220
68positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.34902074
69adhesion of symbiont to host cell (GO:0044650)3.32786899
70virion attachment to host cell (GO:0019062)3.32786899
71regulation of interleukin-5 production (GO:0032674)3.31803219
72toxin metabolic process (GO:0009404)3.29855224
73establishment of planar polarity (GO:0001736)3.26024085
74establishment of tissue polarity (GO:0007164)3.26024085
75gas transport (GO:0015669)3.25939443
76cellular response to reactive nitrogen species (GO:1902170)3.24397462
77O-glycan processing (GO:0016266)3.22435469
78negative regulation of inclusion body assembly (GO:0090084)3.20645366
79dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16142112
80aldehyde catabolic process (GO:0046185)3.15680963
81regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.13849513
82one-carbon compound transport (GO:0019755)3.13428838
83epithelial cell differentiation involved in prostate gland development (GO:0060742)3.12956554
84sexual reproduction (GO:0019953)3.12683062
85membrane raft organization (GO:0031579)3.11077601
86hydrogen peroxide biosynthetic process (GO:0050665)3.10984545
87sodium-independent organic anion transport (GO:0043252)3.10797714
88positive regulation of smoothened signaling pathway (GO:0045880)3.07548127
89spermatid nucleus differentiation (GO:0007289)3.07432428
90drug catabolic process (GO:0042737)3.02697054
91endothelial cell chemotaxis (GO:0035767)2.99192846
92lateral ventricle development (GO:0021670)2.97499979
93peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.96678086
94regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.96517673
95sperm motility (GO:0030317)2.95345712
96peptide catabolic process (GO:0043171)2.93690569
97regulation of integrin-mediated signaling pathway (GO:2001044)2.93486119
98determination of left/right symmetry (GO:0007368)2.91689122
99embryonic viscerocranium morphogenesis (GO:0048703)2.90576135
100respiratory tube development (GO:0030323)2.90065956
101respiratory gaseous exchange (GO:0007585)2.88169661
102L-ascorbic acid metabolic process (GO:0019852)2.86873355
103endocardial cushion development (GO:0003197)2.85640141
104response to laminar fluid shear stress (GO:0034616)2.81556368
105regulation of microtubule depolymerization (GO:0031114)2.81226150
106determination of bilateral symmetry (GO:0009855)2.79100161
107smoothened signaling pathway (GO:0007224)2.78228263
108negative regulation of T cell proliferation (GO:0042130)2.77535199
109left/right axis specification (GO:0070986)2.77327227
110multicellular organismal water homeostasis (GO:0050891)2.76745802
111reactive oxygen species biosynthetic process (GO:1903409)2.76621252
112exogenous drug catabolic process (GO:0042738)2.74669965
113carnitine metabolic process (GO:0009437)2.74152100
114cytoskeletal anchoring at plasma membrane (GO:0007016)2.74007207
115endothelial cell differentiation (GO:0045446)2.73953197
116lateral sprouting from an epithelium (GO:0060601)2.73760932
117outflow tract septum morphogenesis (GO:0003148)2.73141724
118centriole replication (GO:0007099)2.73065589
119microtubule-based process (GO:0007017)2.72765858
120specification of symmetry (GO:0009799)2.72705824
121cell adhesion mediated by integrin (GO:0033627)2.72656957
122cell wall macromolecule metabolic process (GO:0044036)2.72383041
123cell wall macromolecule catabolic process (GO:0016998)2.72383041
124motile cilium assembly (GO:0044458)2.72364383
125regulation of autophagic vacuole assembly (GO:2000785)2.70590884
126oligosaccharide biosynthetic process (GO:0009312)2.69743081
127phosphatidylcholine biosynthetic process (GO:0006656)2.69058183
128excretion (GO:0007588)2.68272496
129regulation of endothelial cell chemotaxis (GO:2001026)2.67377122
130hydrogen peroxide catabolic process (GO:0042744)2.65955726
131hemidesmosome assembly (GO:0031581)2.65907342
132lung alveolus development (GO:0048286)2.65103121
133adhesion of symbiont to host (GO:0044406)2.64434456
134phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.62438638
135organelle assembly (GO:0070925)2.62208861
136retinal rod cell development (GO:0046548)2.61609844
137protein localization to endosome (GO:0036010)2.58056810
138epithelial tube branching involved in lung morphogenesis (GO:0060441)2.57538383
139blood vessel remodeling (GO:0001974)2.56842070
140apical protein localization (GO:0045176)2.56210543
141progesterone metabolic process (GO:0042448)2.55514085
142establishment or maintenance of bipolar cell polarity (GO:0061245)2.55421475
143establishment or maintenance of apical/basal cell polarity (GO:0035088)2.55421475
144hormone catabolic process (GO:0042447)2.55217409
145regulation of secondary heart field cardioblast proliferation (GO:0003266)2.55087894
146regulation of cardioblast proliferation (GO:0003264)2.55087894
147negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.54329497
148neuron remodeling (GO:0016322)2.51263654
149long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.50565103
150artery development (GO:0060840)2.48966684
151polarized epithelial cell differentiation (GO:0030859)2.48267376
152myelin maintenance (GO:0043217)2.47657406
153CDP-diacylglycerol biosynthetic process (GO:0016024)2.46317225
154negative regulation of transcription by competitive promoter binding (GO:0010944)2.45296750
155regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.44063632
156lung epithelium development (GO:0060428)2.43596896
157endocardial cushion morphogenesis (GO:0003203)2.43491616
158Leydig cell differentiation (GO:0033327)2.42285429
159antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.41903043
160antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.41903043
161antigen processing and presentation of endogenous antigen (GO:0019883)2.41528637
162negative regulation of epithelial to mesenchymal transition (GO:0010719)2.40847491
163water homeostasis (GO:0030104)2.40558580
164calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.39452983
165cornea development in camera-type eye (GO:0061303)2.38413840
166iron ion import (GO:0097286)2.37908034
167nonmotile primary cilium assembly (GO:0035058)2.37716804
168protein O-linked glycosylation (GO:0006493)2.37412279
169carnitine transmembrane transport (GO:1902603)2.36741093
170surfactant homeostasis (GO:0043129)12.0690946
171axoneme assembly (GO:0035082)10.3351038

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.87683104
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.55354696
3GATA1_22025678_ChIP-Seq_K562_Human3.98038565
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.48997004
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.23858669
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.16256463
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.60479149
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.59097195
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.53772206
10BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.41190707
11CLOCK_20551151_ChIP-Seq_293T_Human2.30192285
12VDR_22108803_ChIP-Seq_LS180_Human2.23614372
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.14421143
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.01488505
15PIAS1_25552417_ChIP-Seq_VCAP_Human1.94569419
16FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.89700002
17GATA2_21666600_ChIP-Seq_HMVEC_Human1.81100618
18ESR1_21235772_ChIP-Seq_MCF-7_Human1.81062816
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.80803020
20* AHR_22903824_ChIP-Seq_MCF-7_Human1.69872886
21NR3C1_21868756_ChIP-Seq_MCF10A_Human1.61854194
22* TP63_23658742_ChIP-Seq_EP156T_Human1.60249716
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59247899
24* STAT1_20625510_ChIP-Seq_HELA_Human1.57517903
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56884630
26TDRD3_21172665_ChIP-Seq_MCF-7_Human1.56664126
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56094530
28BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.54485994
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.54283628
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51280789
31SOX2_20726797_ChIP-Seq_SW620_Human1.47774102
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47693280
33* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45326003
34* SMC4_20622854_ChIP-Seq_HELA_Human1.45308447
35* ETV1_20927104_ChIP-Seq_GIST48_Human1.44943033
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.44854998
37TBX20_22328084_ChIP-Seq_HEART_Mouse1.44854998
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43000929
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42173329
40* ARNT_22903824_ChIP-Seq_MCF-7_Human1.41616121
41SMRT_27268052_Chip-Seq_Bcells_Human1.41089270
42RAD21_21589869_ChIP-Seq_MESCs_Mouse1.40221776
43LXR_22158963_ChIP-Seq_LIVER_Mouse1.38578396
44* FOXA1_25552417_ChIP-Seq_VCAP_Human1.36831542
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.36673836
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.36132075
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.35398686
48TP63_22573176_ChIP-Seq_HFKS_Human1.34924646
49P63_26484246_Chip-Seq_KERATINOCYTES_Human1.34828823
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33850235
51* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33292416
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.32427459
53CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31403020
54* PHF8_20622853_ChIP-Seq_HELA_Human1.30121177
55TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.29036685
56* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28602835
57* HNFA_21074721_ChIP-Seq_CACO-2_Human1.27483132
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27414561
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.27236680
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.26880748
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25824939
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.25585415
63CJUN_26792858_Chip-Seq_BT549_Human1.25349840
64* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.25007505
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22467856
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21998911
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.21969286
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21006237
69* RBPJ_21746931_ChIP-Seq_IB4_Human1.20889233
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19483186
71GATA1_19941826_ChIP-Seq_K562_Human1.18033254
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17862111
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.17782997
74TP53_18474530_ChIP-ChIP_U2OS_Human1.16489981
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15917167
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15885186
77DROSHA_22980978_ChIP-Seq_HELA_Human1.15008796
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13555566
79* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.13471666
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12371327
81* RUNX1_27514584_Chip-Seq_MCF-7_Human1.11974003
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.11668573
83ZNF263_19887448_ChIP-Seq_K562_Human1.11621302
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11598973
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11112397
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11112397
87* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10661117
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10222567
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10176814
90SMAD3_21741376_ChIP-Seq_HESCs_Human1.09608104
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.09533353
92* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08828805
93* GATA6_21074721_ChIP-Seq_CACO-2_Human1.08776267
94* RACK7_27058665_Chip-Seq_MCF-7_Human1.08311288
95SMAD4_21799915_ChIP-Seq_A2780_Human1.08282255
96* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08243195
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08141040
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07399687
99* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07163664
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06705446
101CEBPB_22108803_ChIP-Seq_LS180_Human1.06675630
102* NFYA_21822215_ChIP-Seq_K562_Human1.06658877
103GATA3_24758297_ChIP-Seq_MCF-7_Human1.05577996
104EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05493703
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.05340893
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05340893
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05155643
108* GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.05012941
109CTCF_20526341_ChIP-Seq_ESCs_Human1.04672220
110KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04244947
111ELK3_25401928_ChIP-Seq_HUVEC_Human1.04149097
112* RXR_22158963_ChIP-Seq_LIVER_Mouse1.03787457
113TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03594602
114TP63_17297297_ChIP-ChIP_HaCaT_Human1.03461775
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03375286
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02767048
117AR_20517297_ChIP-Seq_VCAP_Human1.02718573
118FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02603225
119ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.01769843
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01586020
121GATA4_25053715_ChIP-Seq_YYC3_Human1.00499863
122BCAT_22108803_ChIP-Seq_LS180_Human0.99489888
123SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99486443
124* NFYB_21822215_ChIP-Seq_K562_Human0.99197052
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99189269
126SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98899394
127CTCF_27219007_Chip-Seq_Bcells_Human0.98340224
128PHF8_20622854_ChIP-Seq_HELA_Human0.97613184
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97509299
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.96576888
131SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96055190
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96031716
133KLF5_25053715_ChIP-Seq_YYC3_Human0.95992485
134AR_21572438_ChIP-Seq_LNCaP_Human0.95713930
135P300_27268052_Chip-Seq_Bcells_Human0.94740828
136TCF4_22108803_ChIP-Seq_LS180_Human0.94591953
137* TBL1_22424771_ChIP-Seq_293T_Human0.93289159
138* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92219736
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91585370
140CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90867451
141IRF8_22096565_ChIP-ChIP_GC-B_Human0.90524526
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90434887
143SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90281385
144SOX2_21211035_ChIP-Seq_LN229_Human0.90214385
145TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.89809677
146P68_20966046_ChIP-Seq_HELA_Human0.89783360
147OCT4_20526341_ChIP-Seq_ESCs_Human0.89040123
148NCOR_22424771_ChIP-Seq_293T_Human0.88680408
149PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88564044
150KDM2B_26808549_Chip-Seq_K562_Human0.87641240
151FOXA2_19822575_ChIP-Seq_HepG2_Human0.87622618
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87513984
153RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.87309678
154WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87184572
155RUNX_20019798_ChIP-Seq_JUKART_Human0.86667107
156SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86645954
157SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86645954
158JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85134258
159RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83858072
160EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83858072
161JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83728542
162CDX2_20551321_ChIP-Seq_CACO-2_Human0.83717024
163* LXR_22292898_ChIP-Seq_THP-1_Human0.82872514
164P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81674322
165IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.81623369
166SPI1_23127762_ChIP-Seq_K562_Human0.80818972
167SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80750717
168EGR1_19032775_ChIP-ChIP_M12_Human0.80176415
169JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79801309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.84869591
2MP0002653_abnormal_ependyma_morphology6.62738368
3MP0001958_emphysema5.21006959
4MP0002132_abnormal_respiratory_system4.65968874
5MP0004043_abnormal_pH_regulation4.21528986
6MP0001984_abnormal_olfaction4.15812064
7MP0009780_abnormal_chondrocyte_physiolo3.80077732
8MP0008875_abnormal_xenobiotic_pharmacok3.74816717
9MP0004133_heterotaxia3.56787408
10MP0010368_abnormal_lymphatic_system3.26522497
11MP0002138_abnormal_hepatobiliary_system3.07139126
12MP0008789_abnormal_olfactory_epithelium3.06264229
13MP0005083_abnormal_biliary_tract2.75423567
14MP0001879_abnormal_lymphatic_vessel2.61071845
15MP0008995_early_reproductive_senescence2.54911528
16MP0002277_abnormal_respiratory_mucosa2.44882172
17MP0002139_abnormal_hepatobiliary_system2.34162363
18MP0000383_abnormal_hair_follicle2.27754468
19MP0002133_abnormal_respiratory_system2.27156212
20MP0005388_respiratory_system_phenotype2.27156212
21MP0005167_abnormal_blood-brain_barrier2.23467715
22MP0004019_abnormal_vitamin_homeostasis2.17366999
23MP0003878_abnormal_ear_physiology2.13423356
24MP0005377_hearing/vestibular/ear_phenot2.13423356
25MP0000566_synostosis2.10488048
26MP0003303_peritoneal_inflammation2.07240433
27MP0003191_abnormal_cellular_cholesterol2.06722092
28MP0010678_abnormal_skin_adnexa2.05682377
29MP0002160_abnormal_reproductive_system2.02852320
30MP0003724_increased_susceptibility_to2.00075515
31MP0003950_abnormal_plasma_membrane1.97860031
32MP0003656_abnormal_erythrocyte_physiolo1.96866616
33MP0000465_gastrointestinal_hemorrhage1.91592991
34MP0008004_abnormal_stomach_pH1.90159308
35MP0005394_taste/olfaction_phenotype1.88066502
36MP0005499_abnormal_olfactory_system1.88066502
37MP0002295_abnormal_pulmonary_circulatio1.84464661
38MP0001177_atelectasis1.75272709
39MP0005623_abnormal_meninges_morphology1.69525660
40MP0005058_abnormal_lysosome_morphology1.60292965
41MP0005248_abnormal_Harderian_gland1.57996591
42MP0005171_absent_coat_pigmentation1.55196390
43MP0003705_abnormal_hypodermis_morpholog1.53492900
44MP0005408_hypopigmentation1.53108553
45MP0003566_abnormal_cell_adhesion1.52369326
46MP0003806_abnormal_nucleotide_metabolis1.47173793
47MP0002876_abnormal_thyroid_physiology1.46366253
48MP0005395_other_phenotype1.44158670
49MP0005636_abnormal_mineral_homeostasis1.43604276
50MP0005164_abnormal_response_to1.41201547
51MP0002909_abnormal_adrenal_gland1.40519316
52MP0000678_abnormal_parathyroid_gland1.39743480
53MP0004272_abnormal_basement_membrane1.38716656
54MP0005410_abnormal_fertilization1.36846254
55MP0000343_altered_response_to1.35497605
56MP0001851_eye_inflammation1.35461950
57MP0001849_ear_inflammation1.34420436
58MP0009384_cardiac_valve_regurgitation1.31506101
59MP0000920_abnormal_myelination1.26366607
60MP0005275_abnormal_skin_tensile1.22507503
61MP0001346_abnormal_lacrimal_gland1.17477661
62MP0005595_abnormal_vascular_smooth1.13534320
63MP0004883_abnormal_blood_vessel1.13482634
64MP0010155_abnormal_intestine_physiology1.13478940
65MP0010234_abnormal_vibrissa_follicle1.12632400
66MP0001175_abnormal_lung_morphology1.09343797
67MP0000249_abnormal_blood_vessel1.08371624
68MP0002734_abnormal_mechanical_nocicepti1.07127269
69MP0005389_reproductive_system_phenotype1.05855684
70MP0009046_muscle_twitch1.03602657
71MP0002282_abnormal_trachea_morphology1.02257516
72MP0003195_calcinosis1.01926840
73MP0002102_abnormal_ear_morphology1.01402282
74MP0000537_abnormal_urethra_morphology1.01336282
75MP0001485_abnormal_pinna_reflex1.01041693
76MP0002249_abnormal_larynx_morphology1.00926728
77MP0002233_abnormal_nose_morphology0.99865812
78MP0003329_amyloid_beta_deposits0.99274426
79MP0002168_other_aberrant_phenotype0.98133203
80MP0004084_abnormal_cardiac_muscle0.96167531
81MP0003075_altered_response_to0.95174687
82MP0005220_abnormal_exocrine_pancreas0.91307018
83MP0003091_abnormal_cell_migration0.88522328
84MP0008438_abnormal_cutaneous_collagen0.86839235
85MP0006138_congestive_heart_failure0.86701370
86MP0005365_abnormal_bile_salt0.86596921
87MP0002405_respiratory_system_inflammati0.86107619
88MP0002234_abnormal_pharynx_morphology0.84665345
89MP0002735_abnormal_chemical_nociception0.83740627
90MP0003690_abnormal_glial_cell0.83734714
91MP0005023_abnormal_wound_healing0.83708527
92MP0000681_abnormal_thyroid_gland0.83419268
93MP0004130_abnormal_muscle_cell0.82629631
94MP0005085_abnormal_gallbladder_physiolo0.82065460
95MP0002136_abnormal_kidney_physiology0.81339379
96MP0000534_abnormal_ureter_morphology0.81047568
97MP0003634_abnormal_glial_cell0.80600783
98MP0001765_abnormal_ion_homeostasis0.80556000
99MP0005166_decreased_susceptibility_to0.80186425
100MP0001929_abnormal_gametogenesis0.80139546
101MP0005387_immune_system_phenotype0.79936776
102MP0001790_abnormal_immune_system0.79936776
103MP0003136_yellow_coat_color0.78326265
104MP0002118_abnormal_lipid_homeostasis0.77397646
105MP0010352_gastrointestinal_tract_polyps0.76984418
106MP0003698_abnormal_male_reproductive0.76504632
107MP0005310_abnormal_salivary_gland0.75980175
108MP0000685_abnormal_immune_system0.75572200
109MP0002638_abnormal_pupillary_reflex0.75395962
110MP0003115_abnormal_respiratory_system0.75160005
111MP0005253_abnormal_eye_physiology0.74217179
112MP0003172_abnormal_lysosome_physiology0.72443847
113MP0001666_abnormal_nutrient_absorption0.71168315
114MP0010329_abnormal_lipoprotein_level0.70737809
115MP0003300_gastrointestinal_ulcer0.70230338
116MP0000767_abnormal_smooth_muscle0.69003179
117MP0004264_abnormal_extraembryonic_tissu0.68807175
118MP0001324_abnormal_eye_pigmentation0.68616107
119MP0003453_abnormal_keratinocyte_physiol0.68416660
120MP0001944_abnormal_pancreas_morphology0.68149764
121MP0001270_distended_abdomen0.67809395
122MP0008569_lethality_at_weaning0.67367772
123MP0002925_abnormal_cardiovascular_devel0.66966139
124MP0002098_abnormal_vibrissa_morphology0.66828021
125MP0008872_abnormal_physiological_respon0.66605756
126MP0002128_abnormal_blood_circulation0.65981542
127MP0001502_abnormal_circadian_rhythm0.65922270
128MP0001943_abnormal_respiration0.65824974
129MP0003448_altered_tumor_morphology0.65036636
130MP0009764_decreased_sensitivity_to0.63284888
131MP0000762_abnormal_tongue_morphology0.61742183
132MP0000462_abnormal_digestive_system0.61661189
133MP0004381_abnormal_hair_follicle0.61236655
134MP0003279_aneurysm0.60852627
135MP0000604_amyloidosis0.60633283
136MP0009765_abnormal_xenobiotic_induced0.59395130
137MP0004036_abnormal_muscle_relaxation0.59348753
138MP0002972_abnormal_cardiac_muscle0.58742844
139MP0005165_increased_susceptibility_to0.58123707
140MP0004085_abnormal_heartbeat0.58000134
141MP0004885_abnormal_endolymph0.57662908
142MP0005551_abnormal_eye_electrophysiolog0.55931270
143MP0001664_abnormal_digestion0.55660724
144MP0009643_abnormal_urine_homeostasis0.55601431
145MP0001293_anophthalmia0.55401968
146MP0003866_abnormal_defecation0.54896237
147MP0006082_CNS_inflammation0.54572132
148MP0009763_increased_sensitivity_to0.54438998
149MP0000026_abnormal_inner_ear0.54185817
150MP0002229_neurodegeneration0.54107375
151MP0002928_abnormal_bile_duct0.51483952
152MP0001970_abnormal_pain_threshold0.50770645
153MP0010030_abnormal_orbit_morphology0.50733404
154MP0009379_abnormal_foot_pigmentation0.49946681
155MP0005646_abnormal_pituitary_gland0.49461149
156MP0006036_abnormal_mitochondrial_physio0.48422839
157MP0001663_abnormal_digestive_system0.46647535
158MP0005195_abnormal_posterior_eye0.46358353
159MP0009703_decreased_birth_body0.44548208
160MP0002135_abnormal_kidney_morphology0.41731596
161MP0000631_abnormal_neuroendocrine_gland0.40926382
162MP0008873_increased_physiological_sensi0.40103295
163MP0001963_abnormal_hearing_physiology0.39212408
164MP0000613_abnormal_salivary_gland0.38808896
165MP0005503_abnormal_tendon_morphology0.38713666

Predicted human phenotypes

RankGene SetZ-score
1Interstitial pulmonary disease (HP:0006530)8.37716485
2Chronic bronchitis (HP:0004469)8.19532101
3Hyperactive renin-angiotensin system (HP:0000841)6.68108350
4Abnormality of the nasal mucosa (HP:0000433)5.71564858
5Polycythemia (HP:0001901)5.05349938
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.77442188
7Renal salt wasting (HP:0000127)4.72810058
8Dynein arm defect of respiratory motile cilia (HP:0012255)4.37156505
9Absent/shortened dynein arms (HP:0200106)4.37156505
10Hematochezia (HP:0002573)4.34579521
11Bronchitis (HP:0012387)4.31697148
12Neurofibrillary tangles (HP:0002185)4.28959613
13Abnormal ciliary motility (HP:0012262)4.23598772
14Abnormal respiratory motile cilium physiology (HP:0012261)4.21096570
15Infertility (HP:0000789)4.20002061
16Tubulointerstitial fibrosis (HP:0005576)4.18679676
17Spontaneous hematomas (HP:0007420)4.15876000
18Bronchiectasis (HP:0002110)3.99068314
19Nasal polyposis (HP:0100582)3.95363902
20Male infertility (HP:0003251)3.90132708
21Recurrent otitis media (HP:0000403)3.87048673
22Abnormal respiratory epithelium morphology (HP:0012253)3.83083610
23Abnormal respiratory motile cilium morphology (HP:0005938)3.83083610
24Hyperkalemia (HP:0002153)3.82017801
25Rhinitis (HP:0012384)3.76438972
26Tachypnea (HP:0002789)3.75824589
27Pancreatic fibrosis (HP:0100732)3.71271206
28Occipital encephalocele (HP:0002085)3.63518886
29Gout (HP:0001997)3.63111004
30True hermaphroditism (HP:0010459)3.60619072
31Cerebral inclusion bodies (HP:0100314)3.38221535
32Conjunctival telangiectasia (HP:0000524)3.28983467
33Hyperaldosteronism (HP:0000859)3.24586538
34Respiratory distress (HP:0002098)3.18407405
35Ulnar bowing (HP:0003031)3.18150652
36Visceral angiomatosis (HP:0100761)3.14934117
37Pancreatic cysts (HP:0001737)3.10966421
38Abnormality of midbrain morphology (HP:0002418)3.06179323
39Molar tooth sign on MRI (HP:0002419)3.06179323
40Cystic liver disease (HP:0006706)3.01506132
41Humeroradial synostosis (HP:0003041)2.99581087
42Synostosis involving the elbow (HP:0003938)2.99581087
43Decreased circulating renin level (HP:0003351)2.97705876
44Chronic otitis media (HP:0000389)2.89487779
45Atelectasis (HP:0100750)2.88383034
46Nephronophthisis (HP:0000090)2.87352658
47Hemangiomatosis (HP:0007461)2.82070573
48Abnormality of renin-angiotensin system (HP:0000847)2.80226653
49Chronic sinusitis (HP:0011109)2.75735872
50Esophageal varix (HP:0002040)2.68599996
51Peripheral hypomyelination (HP:0007182)2.66849737
52Tubulointerstitial nephritis (HP:0001970)2.65696270
53Tubulointerstitial abnormality (HP:0001969)2.60867907
54Supranuclear gaze palsy (HP:0000605)2.60024586
55Loss of speech (HP:0002371)2.58383235
56Abnormality of the vasculature of the conjunctiva (HP:0008054)2.56008042
57Abnormality of the fetal cardiovascular system (HP:0010948)2.55934078
58Abnormal umbilical cord blood vessels (HP:0011403)2.55934078
59Single umbilical artery (HP:0001195)2.55934078
60Deep venous thrombosis (HP:0002625)2.54669645
61Postaxial foot polydactyly (HP:0001830)2.52186232
62Chronic hepatic failure (HP:0100626)2.48268996
63Onycholysis (HP:0001806)2.46402907
64Hypotension (HP:0002615)2.45918040
65Mixed hearing impairment (HP:0000410)2.41750505
66Hyponatremia (HP:0002902)2.31832562
67Cerebral hemorrhage (HP:0001342)2.30314186
68Abnormality of the renal medulla (HP:0100957)2.25903525
69Bronchomalacia (HP:0002780)2.23098416
70Osteolytic defects of the hand bones (HP:0009699)2.15306516
71Osteolytic defects of the phalanges of the hand (HP:0009771)2.15306516
72Rapidly progressive (HP:0003678)2.13879790
73Congenital hepatic fibrosis (HP:0002612)2.13198530
74Broad metatarsal (HP:0001783)2.12101860
75Anencephaly (HP:0002323)2.07694538
76Aplasia/Hypoplasia of the tongue (HP:0010295)2.06761216
77Cerebral aneurysm (HP:0004944)2.05560847
78Medial flaring of the eyebrow (HP:0010747)1.99409229
79Male pseudohermaphroditism (HP:0000037)1.99300860
80Bell-shaped thorax (HP:0001591)1.96353107
81Intestinal atresia (HP:0011100)1.94150292
82Bowed forearm bones (HP:0003956)1.93903985
83Bowing of the arm (HP:0006488)1.93903985
84Abnormality of sodium homeostasis (HP:0010931)1.92790856
85Tubular atrophy (HP:0000092)1.90532098
86Abnormality of chloride homeostasis (HP:0011422)1.88871996
87Microcytic anemia (HP:0001935)1.88403197
88Alacrima (HP:0000522)1.85735974
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.85476987
90Asplenia (HP:0001746)1.83925460
91Furrowed tongue (HP:0000221)1.83184430
92Congenital primary aphakia (HP:0007707)1.82622305
93Growth hormone excess (HP:0000845)1.82389223
94Facial shape deformation (HP:0011334)1.82313592
95Potter facies (HP:0002009)1.82313592
96Absent frontal sinuses (HP:0002688)1.80190249
97Hypokalemic alkalosis (HP:0001949)1.80067440
98Gait imbalance (HP:0002141)1.79616027
99Pulmonary embolism (HP:0002204)1.79039966
100Mucosal telangiectasiae (HP:0100579)1.77402204
101Sclerocornea (HP:0000647)1.75116482
102Buphthalmos (HP:0000557)1.74186567
103Pulmonary hypertension (HP:0002092)1.73542420
104Neonatal respiratory distress (HP:0002643)1.73425613
105Recurrent bronchitis (HP:0002837)1.73140513
106Segmental peripheral demyelination/remyelination (HP:0003481)1.72213299
107Oculomotor apraxia (HP:0000657)1.70850399
108Recurrent gram-negative bacterial infections (HP:0005420)1.70275169
109Nephritis (HP:0000123)1.69460979
110Nephropathy (HP:0000112)1.69208371
111Adrenal overactivity (HP:0002717)1.68752107
112Increased purine levels (HP:0004368)1.67989507
113Hyperuricemia (HP:0002149)1.67989507
114Eczematoid dermatitis (HP:0000976)1.65675143
115Recurrent sinusitis (HP:0011108)1.63795327
116Postaxial hand polydactyly (HP:0001162)1.61742089
117Dysostosis multiplex (HP:0000943)1.61137900
118Arterial tortuosity (HP:0005116)1.60682008
119Hypoplasia of the iris (HP:0007676)1.60517517
120Annular pancreas (HP:0001734)1.60184960
121Vascular tortuosity (HP:0004948)1.58927625
122Nephrogenic diabetes insipidus (HP:0009806)1.58605268
123Fragile nails (HP:0001808)1.57529207
124Long toe (HP:0010511)1.55118470
125Stenosis of the external auditory canal (HP:0000402)1.54359233
126Abnormality of the umbilical cord (HP:0010881)1.53526419
127Complement deficiency (HP:0004431)1.53441997
128Pulmonary artery stenosis (HP:0004415)1.52489025
129Abnormality of the salivary glands (HP:0010286)1.52224282
130Vascular calcification (HP:0004934)1.51099896
131Prolonged neonatal jaundice (HP:0006579)1.50345614
132Abnormal hair laboratory examination (HP:0003328)1.49214883
133Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.40116775
134Median cleft lip (HP:0000161)1.34647228
135Preaxial hand polydactyly (HP:0001177)1.33688638
136Absent rod-and cone-mediated responses on ERG (HP:0007688)1.31996828
137Decreased central vision (HP:0007663)1.27048157
138Short thorax (HP:0010306)1.24589048
139Poor coordination (HP:0002370)1.23951575
140Vaginal atresia (HP:0000148)1.22611587
141Genital tract atresia (HP:0001827)1.22609801
142Glucose intolerance (HP:0000833)1.18676223
143Hand muscle atrophy (HP:0009130)1.18385678
144Abnormal drinking behavior (HP:0030082)1.18246946
145Polydipsia (HP:0001959)1.18246946
146Stage 5 chronic kidney disease (HP:0003774)1.17688406
147Cone-rod dystrophy (HP:0000548)1.15048296
148Bifid scrotum (HP:0000048)1.14010346
149Abnormality of the dental root (HP:0006486)1.13205029
150Taurodontia (HP:0000679)1.13205029
151Abnormality of permanent molar morphology (HP:0011071)1.13205029
152Abnormality of the frontal sinuses (HP:0002687)1.12567671
153Fetal akinesia sequence (HP:0001989)1.10544504
154Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.08862622
155Abnormality of the renal cortex (HP:0011035)1.07371225
156Absent speech (HP:0001344)1.06540273
157Abnormal biliary tract physiology (HP:0012439)1.06353036
158Bile duct proliferation (HP:0001408)1.06353036
159Abnormality of molar (HP:0011077)1.03551100
160Abnormality of molar morphology (HP:0011070)1.03551100
161Abnormality of the distal phalanges of the toes (HP:0010182)1.02474089
162Abnormality of macular pigmentation (HP:0008002)1.02459461
163Retinitis pigmentosa (HP:0000510)1.01279156
164Abnormality of the dental pulp (HP:0006479)1.00621111
165Short femoral neck (HP:0100864)1.00366890
166Abnormal rod and cone electroretinograms (HP:0008323)0.99582157
167Popliteal pterygium (HP:0009756)0.99516222
168Supernumerary spleens (HP:0009799)0.98406819
169Abnormality of monocarboxylic acid metabolism (HP:0010996)0.97515219
170Aplasia of the musculature (HP:0100854)0.96406070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.10242158
2TGFBR23.50848616
3LRRK23.07899405
4FGFR22.90159863
5EPHB12.69325303
6MAPKAPK32.47976515
7PDK32.46836522
8PDK42.46836522
9NME12.41351643
10TRPM72.27248275
11MAPK152.24370956
12STK102.01434345
13MST41.94664587
14TTK1.91185716
15SMG11.87057036
16ZAP701.69355908
17SIK11.69275083
18PAK41.64897704
19GRK11.63943462
20FGFR41.55159123
21FGR1.53549902
22LIMK11.52022013
23TLK11.49994358
24EEF2K1.48962607
25FER1.46304030
26DAPK21.43909477
27TESK11.43826802
28PDK21.41883052
29PTK61.40458106
30TRIB31.36403783
31ROCK21.34330994
32PKN11.31288647
33CSK1.30993893
34PDGFRB1.30670569
35PNCK1.30308531
36EPHB21.29659783
37MAP4K11.28840857
38DDR21.28412152
39STK241.26420775
40MAP3K21.25713545
41FRK1.25267238
42ILK1.24278016
43RIPK11.21611866
44DAPK31.19590562
45PRKD11.15421016
46MYLK1.13635389
47KSR21.13283140
48TTN1.09583204
49PTK21.08569652
50EPHA21.05759248
51ITK1.05533626
52NEK61.03029059
53LMTK20.98526684
54RIPK40.97980620
55PRKCI0.97950395
56TYK20.95096975
57EGFR0.89166571
58PAK60.87553418
59MAP3K120.87377356
60STK390.87305189
61MAP3K70.86040733
62PAK30.85600335
63MET0.85457232
64MELK0.85407048
65ERN10.85048528
66JAK10.83218135
67BRSK20.80143590
68ERBB30.80062895
69GSK3A0.79806975
70TBK10.79476345
71PHKG20.79195756
72PHKG10.79195756
73INSRR0.76571165
74MST1R0.76468058
75MAP2K20.75255679
76NLK0.74564026
77NTRK10.73960234
78ADRBK20.73077023
79PDGFRA0.72491519
80CSNK1G30.71171278
81STK380.70732089
82TYRO30.70113017
83HIPK20.68338173
84FYN0.67346349
85PDPK10.66443475
86PRKCH0.65872012
87FGFR30.65567555
88CSNK1A1L0.65524523
89MARK20.64894227
90CSNK1G20.63378599
91CAMKK10.61920632
92OXSR10.60723499
93CLK10.60085382
94MAP3K30.59917190
95SGK4940.58455699
96SGK2230.58455699
97TESK20.58449036
98TEC0.58052518
99PAK20.56823265
100FGFR10.56112949
101KDR0.55979668
102ICK0.55471065
103BCR0.55374397
104MAP3K40.55335527
105IRAK10.55141084
106CAMK2B0.53508633
107PTK2B0.53393551
108PRKCE0.51152570
109PRKAA20.50447418
110SRC0.50360886
111STK38L0.49419589
112BMX0.48265366
113EPHA30.47882726
114PRKCD0.46788435
115CSNK1G10.45690121
116PRKCQ0.45393957
117STK160.45083023
118MAP2K30.43641100
119GRK60.43151746
120CAMK2G0.42858084
121ADRBK10.40192512
122PDK10.40002347
123SGK10.39783306
124UHMK10.39197735
125CSF1R0.39176402
126ROCK10.39063750
127MAPKAPK50.37780668
128ABL10.35113753
129AURKA0.34365451
130JAK20.34000219
131ERBB20.33894247
132PRKCZ0.33886280
133MATK0.33782677
134JAK30.33356400
135MAP4K20.32396555
136LATS10.29301214
137PRKACA0.28009147
138PLK10.27308983
139PRKCA0.25837011
140MAPK130.25427507
141EPHA40.25226962
142DYRK1A0.23854119
143MUSK0.22966823
144TAOK10.22328598
145CAMK2A0.21878859
146PASK0.21685992
147CDC42BPA0.20617263
148DYRK1B0.20246478
149RPS6KB20.20117116
150CAMKK20.20008780
151WNK40.15807589
152AKT20.15357359
153TXK0.15022490
154MAP2K70.14089447
155MAP2K40.13787951
156CHEK20.13015645
157TSSK60.11902481
158IGF1R0.11236022
159CHUK0.10999433
160PRKDC0.10498261
161PRKAA10.07698198

Predicted pathways (KEGG)

RankGene SetZ-score
1Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.11087957
2Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049603.08908577
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.73173601
4Histidine metabolism_Homo sapiens_hsa003402.57441440
5Huntingtons disease_Homo sapiens_hsa050162.57172570
6Linoleic acid metabolism_Homo sapiens_hsa005912.18994848
7Chemical carcinogenesis_Homo sapiens_hsa052042.07935159
8Nitrogen metabolism_Homo sapiens_hsa009102.01474437
9Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84014202
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83295403
11Selenocompound metabolism_Homo sapiens_hsa004501.80200545
12Leukocyte transendothelial migration_Homo sapiens_hsa046701.77273855
13Glutathione metabolism_Homo sapiens_hsa004801.76881761
14Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.75195819
15Mineral absorption_Homo sapiens_hsa049781.69634879
16Fatty acid elongation_Homo sapiens_hsa000621.68504915
17Caffeine metabolism_Homo sapiens_hsa002321.67913955
18ECM-receptor interaction_Homo sapiens_hsa045121.67540396
19Sphingolipid metabolism_Homo sapiens_hsa006001.67129022
20Tight junction_Homo sapiens_hsa045301.57392652
21Lysosome_Homo sapiens_hsa041421.56799030
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.54975886
23Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.52351705
24ABC transporters_Homo sapiens_hsa020101.45464765
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.44933888
26Adherens junction_Homo sapiens_hsa045201.39556008
27Phagosome_Homo sapiens_hsa041451.38352836
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.34643585
29Vibrio cholerae infection_Homo sapiens_hsa051101.28347163
30Peroxisome_Homo sapiens_hsa041461.27398198
31Tryptophan metabolism_Homo sapiens_hsa003801.26292010
32Axon guidance_Homo sapiens_hsa043601.23958686
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23531538
34Sulfur metabolism_Homo sapiens_hsa009201.23486106
35Retinol metabolism_Homo sapiens_hsa008301.23268258
36Salivary secretion_Homo sapiens_hsa049701.18882313
37Salmonella infection_Homo sapiens_hsa051321.17370680
38Renin secretion_Homo sapiens_hsa049241.17166535
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14473308
40Arachidonic acid metabolism_Homo sapiens_hsa005901.14112012
41Malaria_Homo sapiens_hsa051441.12780624
42Phenylalanine metabolism_Homo sapiens_hsa003601.08287510
43Complement and coagulation cascades_Homo sapiens_hsa046101.07006495
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06919585
45beta-Alanine metabolism_Homo sapiens_hsa004101.06552856
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05488525
47Rheumatoid arthritis_Homo sapiens_hsa053231.04186201
48Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00863935
49Focal adhesion_Homo sapiens_hsa045101.00519559
50Fatty acid degradation_Homo sapiens_hsa000710.99555592
51Renal cell carcinoma_Homo sapiens_hsa052110.98093582
52Taste transduction_Homo sapiens_hsa047420.96384643
53Gastric acid secretion_Homo sapiens_hsa049710.92979627
54Amoebiasis_Homo sapiens_hsa051460.91428086
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89788932
56Pertussis_Homo sapiens_hsa051330.89287931
57Starch and sucrose metabolism_Homo sapiens_hsa005000.89207652
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89084939
59Endocytosis_Homo sapiens_hsa041440.88877742
60Collecting duct acid secretion_Homo sapiens_hsa049660.84614618
61Bile secretion_Homo sapiens_hsa049760.81478813
62Phototransduction_Homo sapiens_hsa047440.81171396
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79675770
64Rap1 signaling pathway_Homo sapiens_hsa040150.79070236
65Platelet activation_Homo sapiens_hsa046110.78407160
66Fatty acid biosynthesis_Homo sapiens_hsa000610.77097410
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77082779
68Thyroid hormone synthesis_Homo sapiens_hsa049180.76708350
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.76415082
70Tyrosine metabolism_Homo sapiens_hsa003500.72549642
71Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.71212105
72Renin-angiotensin system_Homo sapiens_hsa046140.70703583
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70594953
74GABAergic synapse_Homo sapiens_hsa047270.70459046
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68894114
76Ether lipid metabolism_Homo sapiens_hsa005650.68258348
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67184578
78Dilated cardiomyopathy_Homo sapiens_hsa054140.66661548
79Staphylococcus aureus infection_Homo sapiens_hsa051500.66512601
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65617295
81Adipocytokine signaling pathway_Homo sapiens_hsa049200.65486887
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63598693
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60330914
84Antigen processing and presentation_Homo sapiens_hsa046120.60086794
85Small cell lung cancer_Homo sapiens_hsa052220.59573128
86Proteoglycans in cancer_Homo sapiens_hsa052050.58874792
87Butanoate metabolism_Homo sapiens_hsa006500.58741502
88Shigellosis_Homo sapiens_hsa051310.58494396
89Olfactory transduction_Homo sapiens_hsa047400.57550639
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57177135
91Morphine addiction_Homo sapiens_hsa050320.57038027
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.57027861
93VEGF signaling pathway_Homo sapiens_hsa043700.55739867
94Circadian rhythm_Homo sapiens_hsa047100.54759753
95Hippo signaling pathway_Homo sapiens_hsa043900.54635385
96Type I diabetes mellitus_Homo sapiens_hsa049400.53809374
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52522604
98Gap junction_Homo sapiens_hsa045400.52236531
99Pancreatic cancer_Homo sapiens_hsa052120.52044817
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.51246464
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.51169507
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50910306
103African trypanosomiasis_Homo sapiens_hsa051430.50198786
104Dorso-ventral axis formation_Homo sapiens_hsa043200.49237670
105Choline metabolism in cancer_Homo sapiens_hsa052310.48866519
106Toxoplasmosis_Homo sapiens_hsa051450.48696825
107Hematopoietic cell lineage_Homo sapiens_hsa046400.48464249
108Viral myocarditis_Homo sapiens_hsa054160.48412348
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.48270527
110Hedgehog signaling pathway_Homo sapiens_hsa043400.46377871
111Tuberculosis_Homo sapiens_hsa051520.45994729
112Pancreatic secretion_Homo sapiens_hsa049720.45392449
113Circadian entrainment_Homo sapiens_hsa047130.44449086
114Chemokine signaling pathway_Homo sapiens_hsa040620.43967842
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43796756
116Fatty acid metabolism_Homo sapiens_hsa012120.43694436
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43295175
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.43234668
119Pathways in cancer_Homo sapiens_hsa052000.43037432
120Hepatitis C_Homo sapiens_hsa051600.42982521
121Bladder cancer_Homo sapiens_hsa052190.42968631
122Prion diseases_Homo sapiens_hsa050200.41987036
123Nicotine addiction_Homo sapiens_hsa050330.41412987
124PPAR signaling pathway_Homo sapiens_hsa033200.41284045
125Ras signaling pathway_Homo sapiens_hsa040140.39059198
126Estrogen signaling pathway_Homo sapiens_hsa049150.38512219
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.38388316
128Vitamin digestion and absorption_Homo sapiens_hsa049770.37564360
129Metabolic pathways_Homo sapiens_hsa011000.37558471
130B cell receptor signaling pathway_Homo sapiens_hsa046620.37535772
131Osteoclast differentiation_Homo sapiens_hsa043800.35230058
132Pentose phosphate pathway_Homo sapiens_hsa000300.34747942
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.33843041
134Notch signaling pathway_Homo sapiens_hsa043300.32045118
135Serotonergic synapse_Homo sapiens_hsa047260.30349360
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29800398
137Basal cell carcinoma_Homo sapiens_hsa052170.29400034
138Cocaine addiction_Homo sapiens_hsa050300.26114966
139Asthma_Homo sapiens_hsa053100.26098631
140Allograft rejection_Homo sapiens_hsa053300.25505411
141Autoimmune thyroid disease_Homo sapiens_hsa053200.25473694
142Regulation of autophagy_Homo sapiens_hsa041400.24218127
143cAMP signaling pathway_Homo sapiens_hsa040240.24190188
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23421413
145Graft-versus-host disease_Homo sapiens_hsa053320.23378830
146Ovarian steroidogenesis_Homo sapiens_hsa049130.23062918
147Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21510800
148Glycerolipid metabolism_Homo sapiens_hsa005610.20382292
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.19404319
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19242588
151Arginine and proline metabolism_Homo sapiens_hsa003300.19001506
152Steroid biosynthesis_Homo sapiens_hsa001000.18671632
153Calcium signaling pathway_Homo sapiens_hsa040200.17612109
154Jak-STAT signaling pathway_Homo sapiens_hsa046300.16074115
155Amphetamine addiction_Homo sapiens_hsa050310.14626242
156Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.14490472
157Insulin resistance_Homo sapiens_hsa049310.13201591
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12973758

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