LDHAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative T cell selection (GO:0043383)5.45233670
2negative regulation of interleukin-12 production (GO:0032695)5.11631118
3activated T cell proliferation (GO:0050798)4.96857846
4cell wall macromolecule catabolic process (GO:0016998)4.96390769
5negative regulation of T cell mediated immunity (GO:0002710)4.79792701
6regulation of B cell receptor signaling pathway (GO:0050855)4.67640552
7positive T cell selection (GO:0043368)4.64788616
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.30913175
9regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.30686544
10positive regulation of gamma-delta T cell activation (GO:0046645)4.29082954
11negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.15013519
12DNA deamination (GO:0045006)4.07178087
13microglial cell activation (GO:0001774)4.03706289
14cell wall macromolecule metabolic process (GO:0044036)4.02206444
15positive regulation by organism of defense response of other organism involved in symbiotic interact3.92652252
16modulation by symbiont of host immune response (GO:0052553)3.92652252
17positive regulation by symbiont of host defense response (GO:0052509)3.92652252
18modulation by symbiont of host defense response (GO:0052031)3.92652252
19modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.92652252
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.92652252
21cytidine metabolic process (GO:0046087)3.86264958
22cytidine catabolic process (GO:0006216)3.86264958
23cytidine deamination (GO:0009972)3.86264958
24positive regulation of interleukin-10 production (GO:0032733)3.82127091
25platelet dense granule organization (GO:0060155)3.82058921
26necroptotic process (GO:0070266)3.81062840
27defense response to protozoan (GO:0042832)3.77673967
28neutrophil mediated immunity (GO:0002446)3.76453600
29regulation of interferon-beta biosynthetic process (GO:0045357)3.72506810
30melanin biosynthetic process (GO:0042438)3.64420061
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.61538625
32secretory granule organization (GO:0033363)3.56386074
33hepatocyte apoptotic process (GO:0097284)3.51276577
34rRNA methylation (GO:0031167)3.50910633
35positive regulation of immunoglobulin mediated immune response (GO:0002891)3.47603802
36positive regulation of B cell mediated immunity (GO:0002714)3.47603802
37positive regulation of alpha-beta T cell proliferation (GO:0046641)3.45068191
38melanin metabolic process (GO:0006582)3.44308669
39positive regulation of T cell mediated cytotoxicity (GO:0001916)3.43272053
40histone mRNA catabolic process (GO:0071044)3.42135659
41developmental pigmentation (GO:0048066)3.41160051
42negative thymic T cell selection (GO:0045060)3.38613323
43positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.33566347
44regulation of alpha-beta T cell proliferation (GO:0046640)3.32464086
45negative regulation of B cell proliferation (GO:0030889)3.31997562
46response to pheromone (GO:0019236)3.31584359
47protein K63-linked deubiquitination (GO:0070536)3.30935532
48programmed necrotic cell death (GO:0097300)3.30624440
49L-fucose catabolic process (GO:0042355)3.29422083
50fucose catabolic process (GO:0019317)3.29422083
51L-fucose metabolic process (GO:0042354)3.29422083
52detection of molecule of bacterial origin (GO:0032490)3.28668504
53pyrimidine ribonucleoside catabolic process (GO:0046133)3.27057510
54response to protozoan (GO:0001562)3.26994890
55T cell selection (GO:0045058)3.21996849
56negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.15155767
57regulation of translational termination (GO:0006449)3.14495834
58lactate metabolic process (GO:0006089)3.13352221
59negative regulation of alpha-beta T cell activation (GO:0046636)3.12390416
60necrotic cell death (GO:0070265)3.12255625
61positive regulation of interleukin-1 beta secretion (GO:0050718)3.10603943
62myeloid leukocyte mediated immunity (GO:0002444)3.10132510
63interferon-gamma production (GO:0032609)3.10057576
64antigen processing and presentation via MHC class Ib (GO:0002475)3.09074931
65negative regulation of lymphocyte mediated immunity (GO:0002707)3.07188070
66regulation of T cell chemotaxis (GO:0010819)3.05088540
67positive regulation of T cell chemotaxis (GO:0010820)3.05088540
68mature B cell differentiation involved in immune response (GO:0002313)3.04951282
69positive regulation of interleukin-1 secretion (GO:0050716)3.01563671
70regulation of gamma-delta T cell activation (GO:0046643)2.99217651
71regulation of gamma-delta T cell differentiation (GO:0045586)2.98440262
72rRNA modification (GO:0000154)2.95878730
73positive regulation of humoral immune response (GO:0002922)2.95659591
74secondary metabolite biosynthetic process (GO:0044550)2.95413165
75B cell receptor signaling pathway (GO:0050853)2.94578241
76regulation of T cell mediated cytotoxicity (GO:0001914)2.94029348
77signal peptide processing (GO:0006465)2.93234867
78positive regulation of response to oxidative stress (GO:1902884)2.92506580
79positive regulation of cellular response to oxidative stress (GO:1900409)2.92506580
80cellular extravasation (GO:0045123)2.92251014
81negative regulation of adaptive immune response (GO:0002820)2.90471444
82melanosome organization (GO:0032438)2.90331194
83cellular response to ATP (GO:0071318)2.88207730
84positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88166708
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.83674862
86mature B cell differentiation (GO:0002335)2.83660501
87pigment granule organization (GO:0048753)2.82729020
88positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.82638213
89regulation of regulatory T cell differentiation (GO:0045589)2.81362450
90regulation of interleukin-1 beta secretion (GO:0050706)2.79893794
91macrophage activation involved in immune response (GO:0002281)2.78529497
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.77717432
93macrophage activation (GO:0042116)2.76254490
94positive regulation of granulocyte differentiation (GO:0030854)2.75959019
95regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.74835731
96regulation of interleukin-10 production (GO:0032653)2.74544876
97maturation of SSU-rRNA (GO:0030490)2.73382465
98response to interleukin-15 (GO:0070672)2.71966025
99T cell proliferation (GO:0042098)2.71088455
100positive thymic T cell selection (GO:0045059)2.67421405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.63685595
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.43733016
3ELF1_17652178_ChIP-ChIP_JURKAT_Human4.28525128
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.05155504
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.59754884
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.34234842
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.97872251
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81579556
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71888043
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.61517824
11MYB_26560356_Chip-Seq_TH2_Human2.35034376
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.34326566
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24940801
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.24454397
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.24342027
16VDR_23849224_ChIP-Seq_CD4+_Human2.08669253
17RUNX_20019798_ChIP-Seq_JUKART_Human2.03357154
18GATA3_26560356_Chip-Seq_TH2_Human1.95831719
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.94606352
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.94124652
21IRF8_27001747_Chip-Seq_BMDM_Mouse1.84970908
22SPI1_23547873_ChIP-Seq_NB4_Human1.81676056
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.73854589
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.73549489
25ELK1_19687146_ChIP-ChIP_HELA_Human1.72883795
26VDR_24787735_ChIP-Seq_THP-1_Human1.66358127
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59380414
28GATA3_27048872_Chip-Seq_THYMUS_Human1.58335020
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.57336997
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56551520
31ER_23166858_ChIP-Seq_MCF-7_Human1.53773930
32MYB_26560356_Chip-Seq_TH1_Human1.53624018
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49383666
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.48161142
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.48152440
36RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45822061
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44158372
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40893214
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39298473
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38799422
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37701310
42FOXP3_21729870_ChIP-Seq_TREG_Human1.36868144
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35652166
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.35025947
45CRX_20693478_ChIP-Seq_RETINA_Mouse1.34565270
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34544340
47SCL_19346495_ChIP-Seq_HPC-7_Human1.33296372
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30562447
49EWS_26573619_Chip-Seq_HEK293_Human1.29840413
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.28790875
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.27056822
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26790332
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26251041
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25681255
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24231331
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21944258
57PU_27001747_Chip-Seq_BMDM_Mouse1.18772914
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18659654
59TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16487443
60SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.14416464
61P300_19829295_ChIP-Seq_ESCs_Human1.12434664
62ZNF274_21170338_ChIP-Seq_K562_Hela1.11745003
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10942029
64PRDM14_20953172_ChIP-Seq_ESCs_Human1.10128677
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08980687
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.08550659
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.08126523
68TP53_22573176_ChIP-Seq_HFKS_Human1.05956608
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05143979
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04089217
71SMRT_27268052_Chip-Seq_Bcells_Human1.03085729
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02230758
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01623859
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.01282052
75TCF4_22108803_ChIP-Seq_LS180_Human1.00655774
76CDX2_22108803_ChIP-Seq_LS180_Human0.98746032
77PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97989725
78SALL4_22934838_ChIP-ChIP_CD34+_Human0.97109983
79BCAT_22108803_ChIP-Seq_LS180_Human0.95328155
80FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95302314
81STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93982054
82TCF4_23295773_ChIP-Seq_U87_Human0.93178677
83GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93077938
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91631712
85ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91580750
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90378957
87FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90295936
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.89237414
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89209465
90P300_18555785_Chip-Seq_ESCs_Mouse0.88968129
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.88208750
92STAT3_23295773_ChIP-Seq_U87_Human0.87669943
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87024658
94TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86485204
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.86118239
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85282626
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84751952
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83514279
99CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.82569409
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.82474715

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.90192702
2MP0000015_abnormal_ear_pigmentation5.16226336
3MP0005174_abnormal_tail_pigmentation4.81250618
4MP0004381_abnormal_hair_follicle3.92884223
5MP0005408_hypopigmentation3.50930906
6MP0005075_abnormal_melanosome_morpholog3.24064190
7MP0000372_irregular_coat_pigmentation3.07940644
8MP0005171_absent_coat_pigmentation3.03546214
9MP0002166_altered_tumor_susceptibility2.82116151
10MP0002095_abnormal_skin_pigmentation2.62743570
11MP0001835_abnormal_antigen_presentation2.60579613
12MP0002396_abnormal_hematopoietic_system2.46200571
13MP0000371_diluted_coat_color2.32721828
14MP0003172_abnormal_lysosome_physiology2.14644217
15MP0009785_altered_susceptibility_to2.11012480
16MP0005671_abnormal_response_to2.10937989
17MP0001800_abnormal_humoral_immune2.05589708
18MP0001790_abnormal_immune_system2.04341440
19MP0005387_immune_system_phenotype2.04341440
20MP0002006_tumorigenesis2.02192447
21MP0003763_abnormal_thymus_physiology1.97286080
22MP0003724_increased_susceptibility_to1.85418894
23MP0008057_abnormal_DNA_replication1.74198813
24MP0002723_abnormal_immune_serum1.72314396
25MP0003806_abnormal_nucleotide_metabolis1.71322121
26MP0003436_decreased_susceptibility_to1.70041641
27MP0005025_abnormal_response_to1.69749831
28MP0009333_abnormal_splenocyte_physiolog1.69476598
29MP0002452_abnormal_antigen_presenting1.67921054
30MP0002420_abnormal_adaptive_immunity1.67049539
31MP0001819_abnormal_immune_cell1.63652795
32MP0003136_yellow_coat_color1.63287957
33MP0000685_abnormal_immune_system1.62122208
34MP0002419_abnormal_innate_immunity1.57080968
35MP0003303_peritoneal_inflammation1.56451201
36MP0005000_abnormal_immune_tolerance1.47977815
37MP0002148_abnormal_hypersensitivity_rea1.46076725
38MP0003656_abnormal_erythrocyte_physiolo1.43339872
39MP0002075_abnormal_coat/hair_pigmentati1.40919016
40MP0009764_decreased_sensitivity_to1.30936684
41MP0003300_gastrointestinal_ulcer1.30559725
42MP0006082_CNS_inflammation1.29601636
43MP0002398_abnormal_bone_marrow1.24769044
44MP0002405_respiratory_system_inflammati1.24391124
45MP0001845_abnormal_inflammatory_respons1.22419754
46MP0003045_fibrosis1.21660164
47MP0005310_abnormal_salivary_gland1.18795295
48MP0000689_abnormal_spleen_morphology1.18676453
49MP0000716_abnormal_immune_system1.18434946
50MP0001851_eye_inflammation1.17180604
51MP0001186_pigmentation_phenotype1.15207337
52MP0003448_altered_tumor_morphology1.09083438
53MP0001324_abnormal_eye_pigmentation1.08755432
54MP0005670_abnormal_white_adipose1.05968996
55MP0000703_abnormal_thymus_morphology1.01249746
56MP0002009_preneoplasia0.98812886
57MP0002722_abnormal_immune_system0.98317550
58MP0001986_abnormal_taste_sensitivity0.91712561
59MP0003195_calcinosis0.89692859
60MP0002429_abnormal_blood_cell0.89672795
61MP0005377_hearing/vestibular/ear_phenot0.89642796
62MP0003878_abnormal_ear_physiology0.89642796
63MP0008007_abnormal_cellular_replicative0.89066027
64MP0005464_abnormal_platelet_physiology0.86548240
65MP0004142_abnormal_muscle_tone0.85486175
66MP0003866_abnormal_defecation0.82334446
67MP0008260_abnormal_autophagy0.78883414
68MP0002877_abnormal_melanocyte_morpholog0.77613808
69MP0010155_abnormal_intestine_physiology0.75527976
70MP0003186_abnormal_redox_activity0.71219659
71MP0005248_abnormal_Harderian_gland0.70600164
72MP0003786_premature_aging0.69301730
73MP0001501_abnormal_sleep_pattern0.68073117
74MP0008469_abnormal_protein_level0.67311671
75MP0008873_increased_physiological_sensi0.67272027
76MP0002928_abnormal_bile_duct0.66211643
77MP0001853_heart_inflammation0.65552012
78MP0004808_abnormal_hematopoietic_stem0.64983426
79MP0001958_emphysema0.63196564
80MP0002638_abnormal_pupillary_reflex0.63159838
81MP0002938_white_spotting0.62098528
82MP0009763_increased_sensitivity_to0.61885753
83MP0005058_abnormal_lysosome_morphology0.61862118
84MP0008877_abnormal_DNA_methylation0.61515083
85MP0008058_abnormal_DNA_repair0.61070786
86MP0003693_abnormal_embryo_hatching0.61054435
87MP0004883_abnormal_blood_vessel0.61044424
88MP0001533_abnormal_skeleton_physiology0.60753058
89MP0000427_abnormal_hair_cycle0.59063239
90MP0005584_abnormal_enzyme/coenzyme_acti0.54773200
91MP0005266_abnormal_metabolism0.53962484
92MP0003252_abnormal_bile_duct0.53880932
93MP0002177_abnormal_outer_ear0.53449578
94MP0002019_abnormal_tumor_incidence0.52513866
95MP0005551_abnormal_eye_electrophysiolog0.52244398
96MP0002168_other_aberrant_phenotype0.51671858
97MP0001873_stomach_inflammation0.47486683
98MP0004134_abnormal_chest_morphology0.47300802
99MP0002332_abnormal_exercise_endurance0.46594794
100MP0005389_reproductive_system_phenotype0.46506906

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.08674088
2Large for gestational age (HP:0001520)4.33424990
3Aplasia/Hypoplasia of the macula (HP:0008059)4.25746475
4Albinism (HP:0001022)4.25192208
5Optic neuritis (HP:0100653)4.05672260
6Retrobulbar optic neuritis (HP:0100654)4.05672260
7Ocular albinism (HP:0001107)4.02258935
8Aplasia/Hypoplasia affecting the retina (HP:0008061)3.95622583
9Hypoproteinemia (HP:0003075)3.70832621
10Generalized hypopigmentation (HP:0007513)3.63264075
11Abnormality of the pons (HP:0007361)3.62680250
12Orchitis (HP:0100796)3.51232752
13Hypoplasia of the fovea (HP:0007750)3.47817603
14Aplasia/Hypoplasia of the fovea (HP:0008060)3.47817603
15Abnormality of T cell number (HP:0011839)3.46938186
16T lymphocytopenia (HP:0005403)3.40131397
17Iris hypopigmentation (HP:0007730)3.38238214
18Abnormal gallbladder physiology (HP:0012438)3.35992723
19Cholecystitis (HP:0001082)3.35992723
20Recurrent bacterial skin infections (HP:0005406)3.34990864
21Myositis (HP:0100614)3.30221346
22Pancreatic cysts (HP:0001737)3.09399310
23Hypoplasia of the pons (HP:0012110)3.04363683
24Recurrent abscess formation (HP:0002722)3.02109667
25Elevated erythrocyte sedimentation rate (HP:0003565)2.95773942
26Progressive inability to walk (HP:0002505)2.88113863
27Duplicated collecting system (HP:0000081)2.87455601
28Keratoconjunctivitis sicca (HP:0001097)2.80653623
29Chronic diarrhea (HP:0002028)2.77044799
30Keratoconjunctivitis (HP:0001096)2.73151907
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.71249422
32Bilateral sensorineural hearing impairment (HP:0008619)2.71187472
33Generalized hypopigmentation of hair (HP:0011358)2.64902176
34Patchy hypopigmentation of hair (HP:0011365)2.61644012
35Abnormality of the fovea (HP:0000493)2.59450497
36Recurrent fungal infections (HP:0002841)2.56239642
37Abnormality of the renal collecting system (HP:0004742)2.55852159
38Autoimmune hemolytic anemia (HP:0001890)2.55296412
39Eosinophilia (HP:0001880)2.54353155
40Pulmonary infiltrates (HP:0002113)2.50278422
41Reduced antithrombin III activity (HP:0001976)2.46223204
42Congenital sensorineural hearing impairment (HP:0008527)2.42141331
43Hypochromic microcytic anemia (HP:0004840)2.40868944
44Abnormality of glycolysis (HP:0004366)2.40515182
45White forelock (HP:0002211)2.40473455
46Hemoptysis (HP:0002105)2.40315224
47Abnormality of T cells (HP:0002843)2.39315330
48Abnormality of eosinophils (HP:0001879)2.38683435
49Long foot (HP:0001833)2.37009910
50Congenital stationary night blindness (HP:0007642)2.36923255
51Blue irides (HP:0000635)2.35035891
52Constricted visual fields (HP:0001133)2.32494409
53Premature graying of hair (HP:0002216)2.31984263
54Type I transferrin isoform profile (HP:0003642)2.29923870
55Clubbing of toes (HP:0100760)2.29874112
56Arterial thrombosis (HP:0004420)2.24117830
57Recurrent skin infections (HP:0001581)2.22055736
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.21937686
59Decreased activity of mitochondrial respiratory chain (HP:0008972)2.21937686
60Abnormality of the renal cortex (HP:0011035)2.19347111
61Facial diplegia (HP:0001349)2.19218269
62Thyroiditis (HP:0100646)2.19080624
63IgM deficiency (HP:0002850)2.17049195
64Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15150018
65Absent speech (HP:0001344)2.14428374
66Encephalitis (HP:0002383)2.13811094
67Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10282626
68Granulocytopenia (HP:0001913)2.06640516
69Leukocytosis (HP:0001974)2.05679075
70Cutaneous melanoma (HP:0012056)2.04870080
71Abnormality of DNA repair (HP:0003254)2.03080383
72Chest pain (HP:0100749)2.01564797
73Widely spaced teeth (HP:0000687)2.00892653
74Abnormality of the prostate (HP:0008775)2.00364841
75Poor head control (HP:0002421)2.00131675
76Vasculitis (HP:0002633)1.97841211
77Chronic mucocutaneous candidiasis (HP:0002728)1.97633852
78Recurrent cutaneous fungal infections (HP:0011370)1.97633852
79Gangrene (HP:0100758)1.96865923
80Pancreatic fibrosis (HP:0100732)1.95237907
81Mediastinal lymphadenopathy (HP:0100721)1.93903771
82Prostate neoplasm (HP:0100787)1.91711004
83Keratitis (HP:0000491)1.91605082
84Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.91154340
85Abnormal protein N-linked glycosylation (HP:0012347)1.91154340
86Abnormal protein glycosylation (HP:0012346)1.91154340
87Abnormal glycosylation (HP:0012345)1.91154340
88Attenuation of retinal blood vessels (HP:0007843)1.90469484
89Pancreatic islet-cell hyperplasia (HP:0004510)1.88633192
90Molar tooth sign on MRI (HP:0002419)1.86374284
91Abnormality of midbrain morphology (HP:0002418)1.86374284
92Abnormality of B cell number (HP:0010975)1.83755949
93Pulmonary embolism (HP:0002204)1.82027314
94Severe visual impairment (HP:0001141)1.81809868
95True hermaphroditism (HP:0010459)1.79566506
96Exotropia (HP:0000577)1.79027186
97Acute hepatic failure (HP:0006554)1.78626462
98Recurrent viral infections (HP:0004429)1.76695917
99Amyloidosis (HP:0011034)1.75464151
100Meningitis (HP:0001287)1.75368208

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.10183183
2FRK4.09125984
3NUAK12.81830626
4PDK22.58880241
5TAOK32.50839579
6BLK2.42944357
7IKBKE2.40847447
8NEK92.13314259
9TSSK62.04541339
10MAP2K31.95585569
11MAP2K61.94423903
12TYK21.83693710
13STK161.82489368
14IRAK41.81968516
15MARK31.80808156
16IRAK11.77482797
17TEC1.68553851
18MST41.52316688
19PAK31.48090527
20PLK21.47282556
21EIF2AK31.46684095
22IKBKB1.44979500
23SYK1.44812736
24MAP3K61.44237484
25FES1.43964823
26WNK11.42396163
27CSK1.40946851
28IRAK21.38119466
29RIPK41.37823235
30KIT1.35668115
31BMPR21.34996650
32ACVR1B1.30087429
33JAK31.29983806
34GRK61.28620587
35WNK41.28267389
36ZAP701.25526961
37ITK1.20349361
38ERBB31.19302875
39MAP4K11.17170518
40PIK3CG1.13733168
41PTK2B1.11578322
42RAF11.11530092
43EIF2AK11.08333149
44ADRBK21.08145041
45MAP3K31.06209597
46RPS6KA41.05818508
47DMPK1.04457735
48LYN1.02837990
49CAMKK21.02130952
50PAK60.96871229
51PIK3CA0.95991783
52GRK50.93885729
53BUB10.90985831
54STK40.90620426
55PASK0.89345759
56MAP3K140.88316029
57OXSR10.86795285
58SRPK10.83893179
59LCK0.83836103
60TLK10.83332467
61BTK0.82845053
62CSNK1A1L0.82746729
63HIPK20.79474825
64MATK0.78755756
65RPS6KA50.77683781
66CDK190.76318780
67HCK0.73688892
68FER0.73438302
69CSNK1G30.70827894
70YES10.64203794
71MAP3K130.63416871
72CSNK1G10.62954481
73STK30.61514915
74PLK30.61453682
75STK390.61220142
76NEK60.59932266
77TAOK20.56128029
78ADRBK10.55835575
79STK100.54178384
80MAP3K50.51484927
81PRKCQ0.51292419
82CSNK1G20.50942380
83FGR0.50559361
84MAP3K20.50265705
85PDK10.49445037
86GRK10.47488897
87ABL10.47382533
88JAK10.46471256
89GSK3A0.44616231
90PIM10.41207273
91TBK10.40848008
92ERBB20.39094627
93PRKG10.37933578
94JAK20.37717810
95BCKDK0.36559906
96PRKCI0.36284642
97MAP3K120.36216184
98BMPR1B0.33814190
99CSF1R0.33511872
100FGFR20.32365712

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.91289061
2Allograft rejection_Homo sapiens_hsa053303.68784287
3Autoimmune thyroid disease_Homo sapiens_hsa053203.59030483
4Type I diabetes mellitus_Homo sapiens_hsa049403.41430670
5NOD-like receptor signaling pathway_Homo sapiens_hsa046212.89387208
6Proteasome_Homo sapiens_hsa030502.72822224
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.36146378
8Asthma_Homo sapiens_hsa053102.35465699
9Primary immunodeficiency_Homo sapiens_hsa053402.25495097
10Antigen processing and presentation_Homo sapiens_hsa046122.23470250
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19189072
12Leishmaniasis_Homo sapiens_hsa051401.96378758
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.88226341
14T cell receptor signaling pathway_Homo sapiens_hsa046601.79062006
15Hematopoietic cell lineage_Homo sapiens_hsa046401.77430020
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.73280373
17Legionellosis_Homo sapiens_hsa051341.69910349
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67764106
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67664310
20Measles_Homo sapiens_hsa051621.63319979
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.62371874
22Osteoclast differentiation_Homo sapiens_hsa043801.61432729
23Staphylococcus aureus infection_Homo sapiens_hsa051501.55377334
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.45891557
25Nitrogen metabolism_Homo sapiens_hsa009101.43106052
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40437141
27Rheumatoid arthritis_Homo sapiens_hsa053231.35653866
28Protein export_Homo sapiens_hsa030601.33066906
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.32758655
30Fanconi anemia pathway_Homo sapiens_hsa034601.32145523
31Malaria_Homo sapiens_hsa051441.26536814
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25014628
33Homologous recombination_Homo sapiens_hsa034401.24633411
34Tuberculosis_Homo sapiens_hsa051521.24230928
35Linoleic acid metabolism_Homo sapiens_hsa005911.19226152
36Influenza A_Homo sapiens_hsa051641.13173768
37Herpes simplex infection_Homo sapiens_hsa051681.10467297
38Basal transcription factors_Homo sapiens_hsa030221.01760061
39Non-homologous end-joining_Homo sapiens_hsa034501.00540991
40Pentose phosphate pathway_Homo sapiens_hsa000301.00435380
41Dorso-ventral axis formation_Homo sapiens_hsa043200.97895819
42RNA transport_Homo sapiens_hsa030130.97807697
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97607675
44B cell receptor signaling pathway_Homo sapiens_hsa046620.92424086
45RNA polymerase_Homo sapiens_hsa030200.91751343
46Nucleotide excision repair_Homo sapiens_hsa034200.91748247
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.91245082
48RNA degradation_Homo sapiens_hsa030180.90940015
49Epstein-Barr virus infection_Homo sapiens_hsa051690.85353264
50N-Glycan biosynthesis_Homo sapiens_hsa005100.85327922
51Platelet activation_Homo sapiens_hsa046110.84633835
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82928436
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80833294
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78972596
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.78549643
56Apoptosis_Homo sapiens_hsa042100.75865164
57Sulfur metabolism_Homo sapiens_hsa009200.74655553
58Viral myocarditis_Homo sapiens_hsa054160.72311605
59Propanoate metabolism_Homo sapiens_hsa006400.71324093
60ABC transporters_Homo sapiens_hsa020100.71279418
61TNF signaling pathway_Homo sapiens_hsa046680.70498357
62Toxoplasmosis_Homo sapiens_hsa051450.66006484
63Hepatitis B_Homo sapiens_hsa051610.65564268
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65396393
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65298225
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64087639
67One carbon pool by folate_Homo sapiens_hsa006700.64031483
68Ether lipid metabolism_Homo sapiens_hsa005650.62122039
69Regulation of autophagy_Homo sapiens_hsa041400.59218905
70Fatty acid elongation_Homo sapiens_hsa000620.59024085
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56469104
72African trypanosomiasis_Homo sapiens_hsa051430.55055878
73Phagosome_Homo sapiens_hsa041450.54890593
74Chemokine signaling pathway_Homo sapiens_hsa040620.52761748
75Spliceosome_Homo sapiens_hsa030400.52360956
76Pertussis_Homo sapiens_hsa051330.51194976
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49839977
78Parkinsons disease_Homo sapiens_hsa050120.46521620
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45633378
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44145678
81Ovarian steroidogenesis_Homo sapiens_hsa049130.42722905
82Oxidative phosphorylation_Homo sapiens_hsa001900.41377279
83Tryptophan metabolism_Homo sapiens_hsa003800.39489506
84Phototransduction_Homo sapiens_hsa047440.38853838
85Collecting duct acid secretion_Homo sapiens_hsa049660.38772287
86Arachidonic acid metabolism_Homo sapiens_hsa005900.38745839
87Fructose and mannose metabolism_Homo sapiens_hsa000510.38662179
88Renin-angiotensin system_Homo sapiens_hsa046140.34967296
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33982680
90Systemic lupus erythematosus_Homo sapiens_hsa053220.33742986
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32136844
92HIF-1 signaling pathway_Homo sapiens_hsa040660.31743986
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.29936453
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29800311
95Galactose metabolism_Homo sapiens_hsa000520.29512150
96Vitamin digestion and absorption_Homo sapiens_hsa049770.29445317
97Peroxisome_Homo sapiens_hsa041460.28215836
98Glycerolipid metabolism_Homo sapiens_hsa005610.27215329
99Olfactory transduction_Homo sapiens_hsa047400.26947003
100Base excision repair_Homo sapiens_hsa034100.25814012

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